AU2992492A - The use of d-fenfluramine and fenfluramine compounds in the treatment of hypertension in insulin-resistant subjects - Google Patents
The use of d-fenfluramine and fenfluramine compounds in the treatment of hypertension in insulin-resistant subjectsInfo
- Publication number
- AU2992492A AU2992492A AU29924/92A AU2992492A AU2992492A AU 2992492 A AU2992492 A AU 2992492A AU 29924/92 A AU29924/92 A AU 29924/92A AU 2992492 A AU2992492 A AU 2992492A AU 2992492 A AU2992492 A AU 2992492A
- Authority
- AU
- Australia
- Prior art keywords
- fenfluramine
- hypertension
- insulin
- treatment
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- DBGIVFWFUFKIQN-VIFPVBQESA-N (+)-Fenfluramine Chemical compound CCN[C@@H](C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-VIFPVBQESA-N 0.000 title 1
- DBGIVFWFUFKIQN-UHFFFAOYSA-N (+-)-Fenfluramine Chemical class CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-UHFFFAOYSA-N 0.000 title 1
- 206010020772 Hypertension Diseases 0.000 title 1
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229960004597 dexfenfluramine Drugs 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9115122A FR2684552B1 (en) | 1991-12-06 | 1991-12-06 | USE OF D-FENFLURAMINE AND FENFLURAMINE DERIVATIVES IN THE TREATMENT OF HYPERTENSION IN INSULIN RESISTANT SUBJECTS. |
| FR9115122 | 1991-12-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2992492A true AU2992492A (en) | 1993-06-10 |
| AU657015B2 AU657015B2 (en) | 1995-02-23 |
Family
ID=9419739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU29924/92A Ceased AU657015B2 (en) | 1991-12-06 | 1992-12-04 | The use of d-fenfluramine and fenfluramine compounds in the treatment of hypertension in insulin-resistant subjects |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0545805A1 (en) |
| JP (1) | JPH07103021B2 (en) |
| AU (1) | AU657015B2 (en) |
| CA (1) | CA2084641A1 (en) |
| FR (1) | FR2684552B1 (en) |
| ZA (1) | ZA929390B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9549909B2 (en) * | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
| ES2861774T3 (en) | 2015-12-22 | 2021-10-06 | Zogenix International Ltd | Fenfluramine Compositions and Procedures for Making Them |
| EP3393470B1 (en) | 2015-12-22 | 2021-01-20 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
| EP3518975A1 (en) | 2016-08-24 | 2019-08-07 | Zogenix International Limited | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
| US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
| CA3097335A1 (en) | 2018-05-11 | 2019-11-14 | Zogenix International Limited | Compositions and methods for treating seizure-induced sudden death |
| EP3806835A1 (en) | 2018-06-14 | 2021-04-21 | Zogenix International Limited | Compositions and methods for treating respiratory depression with fenfluramine |
| US11612574B2 (en) | 2020-07-17 | 2023-03-28 | Zogenix International Limited | Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309445A (en) * | 1980-06-16 | 1982-01-05 | Massachusetts Institute Of Technology | d-Fenfluramine for modifying feeding behavior |
| US4452815A (en) * | 1980-06-16 | 1984-06-05 | Massachusetts Institute Of Technology | Method of utilizing d,l-fenfluramine for modifying feeding behavior |
| FR2502952A1 (en) * | 1981-04-07 | 1982-10-08 | Science Union & Cie | NEW BENFLUOREX HYDROCHLORIDE DRUG FOR THE TREATMENT OF DIABETES |
| US4649161A (en) * | 1986-06-16 | 1987-03-10 | Massachusetts Institute Of Technology | Method for treating depression with d-fenfluramine |
-
1991
- 1991-12-06 FR FR9115122A patent/FR2684552B1/en not_active Expired - Fee Related
-
1992
- 1992-12-01 EP EP92403233A patent/EP0545805A1/en not_active Withdrawn
- 1992-12-03 ZA ZA929390A patent/ZA929390B/en unknown
- 1992-12-04 CA CA002084641A patent/CA2084641A1/en not_active Abandoned
- 1992-12-04 AU AU29924/92A patent/AU657015B2/en not_active Ceased
- 1992-12-07 JP JP4327027A patent/JPH07103021B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2684552B1 (en) | 1995-04-28 |
| FR2684552A1 (en) | 1993-06-11 |
| ZA929390B (en) | 1993-06-07 |
| AU657015B2 (en) | 1995-02-23 |
| EP0545805A1 (en) | 1993-06-09 |
| JPH07103021B2 (en) | 1995-11-08 |
| JPH05310564A (en) | 1993-11-22 |
| CA2084641A1 (en) | 1993-06-07 |
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