AU2943792A - Epothilones, process for preparing the same and their use as medicaments and as plant protecting agents - Google Patents

Epothilones, process for preparing the same and their use as medicaments and as plant protecting agents

Info

Publication number
AU2943792A
AU2943792A AU29437/92A AU2943792A AU2943792A AU 2943792 A AU2943792 A AU 2943792A AU 29437/92 A AU29437/92 A AU 29437/92A AU 2943792 A AU2943792 A AU 2943792A AU 2943792 A AU2943792 A AU 2943792A
Authority
AU
Australia
Prior art keywords
epothilones
medicaments
preparing
process
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU29437/92A
Inventor
Norbert Bedorf
Klaus Gerth
Gerhard Hofle
Hans Reichenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ciba Geigy AG
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Original Assignee
Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE19914138042 priority Critical patent/DE4138042C2/en
Priority to DE4138042 priority
Application filed by Helmholtz Zentrum fuer Infektionsforschung HZI GmbH filed Critical Helmholtz Zentrum fuer Infektionsforschung HZI GmbH
Publication of AU2943792A publication Critical patent/AU2943792A/en
Application status is Abandoned legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
AU29437/92A 1991-11-19 1992-11-19 Epothilones, process for preparing the same and their use as medicaments and as plant protecting agents Abandoned AU2943792A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19914138042 DE4138042C2 (en) 1991-11-19 1991-11-19 Epothilones, their method of preparation as well as agents containing these compounds
DE4138042 1991-11-19

Publications (1)

Publication Number Publication Date
AU2943792A true AU2943792A (en) 1993-06-15

Family

ID=6445140

Family Applications (1)

Application Number Title Priority Date Filing Date
AU29437/92A Abandoned AU2943792A (en) 1991-11-19 1992-11-19 Epothilones, process for preparing the same and their use as medicaments and as plant protecting agents

Country Status (3)

Country Link
AU (1) AU2943792A (en)
DE (1) DE4138042C2 (en)
WO (1) WO1993010121A1 (en)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
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NZ511722A (en) 1998-11-20 2004-05-28 Kosan Biosciences Inc Recombinant methods and materials for producing epothilone and epothilone derivatives
US6780620B1 (en) 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
EP1161430A2 (en) 1999-02-11 2001-12-12 Schering Aktiengesellschaft Epothilon derivatives, method for the production and the use thereof as pharmaceuticals
IL144501D0 (en) 1999-02-22 2002-05-23 Biotechnolog Forschung Gmbh Epothilone derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
US6291684B1 (en) 1999-03-29 2001-09-18 Bristol-Myers Squibb Company Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
IL144910D0 (en) 1999-04-15 2002-06-30 Squibb Bristol Myers Co Cyclic compounds and pharmaceutical compositions containing the same
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
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GB0029895D0 (en) 2000-12-07 2001-01-24 Novartis Ag Organic compounds
SK8552003A3 (en) 2001-01-25 2004-06-08 Squibb Bristol Myers Co Parenteral formulation containing epothilone analogs
EE05301B1 (en) 2001-01-25 2010-06-15 Bristol-Myers Squibb Company A process for the preparation of pharmaceutical formulations containing the epothilone analogs, and their use in the manufacture of a medicament
NZ526871A (en) 2001-01-25 2006-01-27 Squibb Bristol Myers Co Pharmaceutical dosage forms of epothilones for oral administration
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CN1774253A (en) 2001-02-20 2006-05-17 布里斯托尔-迈尔斯斯奎布公司 Treatment of refractory tumors using epothilone derivatives
CN1610549A (en) 2001-02-20 2005-04-27 布里斯托尔-迈尔斯斯奎布公司 Epermycin derivative for treating difficult to cure tumor
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US7008936B2 (en) 2002-06-14 2006-03-07 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
CN102532120A (en) 2002-08-23 2012-07-04 索隆-基特林癌症研究协会 Synthesis of EPOTHILONE, intermediates thereto, analogues and uses thereof
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US20050171167A1 (en) 2003-11-04 2005-08-04 Haby Thomas A. Process and formulation containing epothilones and analogs thereof
DE10355223A1 (en) 2003-11-26 2005-06-30 Institut für Pflanzenbiochemie (IPB) New macrocycles for the treatment of cancer
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US20060121511A1 (en) 2004-11-30 2006-06-08 Hyerim Lee Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents
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RU2009125599A (en) 2006-12-04 2011-01-20 Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Иллинойс (Us) Compositions and methods for treating cancer with cpg-rich dna and cupredoxins
WO2008147941A1 (en) 2007-05-25 2008-12-04 Bristol-Myers Squibb Company Processes for making epothilone compounds and analogs
EP2065054A1 (en) 2007-11-29 2009-06-03 Bayer Schering Pharma Aktiengesellschaft Combinations comprising a prostaglandin and uses thereof
DE102007059752A1 (en) 2007-12-10 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Functionalized solid polymer nanoparticles containing epothilones
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JP5180321B2 (en) * 2008-02-01 2013-04-10 浙江海正薬業股▲ふん▼有限公司Zhejiang Hisun Pharmaceutical CO.,LTD. Separation and purification method of epothilone
CN101362784A (en) * 2008-10-06 2009-02-11 山东大学 Ebomycin glycosides compounds, composition using the same as activity component and use thereof
EP2210584A1 (en) 2009-01-27 2010-07-28 Bayer Schering Pharma Aktiengesellschaft Stable polymeric composition comprising an epothilone and an amphiphilic block copolymer
EA201201400A1 (en) 2010-05-18 2013-03-29 Серулин Фарма Инк. Compositions and methods of treatment of autoimmune and other diseases
US8618146B2 (en) 2011-01-03 2013-12-31 Dr. Reddy's Laboratories Limited Epothilone compound formulations
CN102863474A (en) 2011-07-09 2013-01-09 陈小平 Platinum compounds for treating cell proliferative diseases and preparation method and application thereof
CN102993239A (en) 2011-09-19 2013-03-27 陈小平 Platinum compound of succinic acid derivative with leaving group containing amino or alkylamino
EP2924044B1 (en) 2012-11-17 2018-10-31 Beijing Shuobai Pharmaceutical Co., LTD Platinum compound of malonic acid derivative having leaving group containing amino or alkylamino
CN103145722B (en) * 2013-03-05 2015-12-02 福建省微生物研究所 A kind of method of high speed adverse current chromatogram separating-purifying ebormycine
US20160185793A1 (en) * 2013-08-19 2016-06-30 Sandoz Ag Method for the purification of epothilones via crystallization

Also Published As

Publication number Publication date
DE4138042A1 (en) 1993-05-27
DE4138042C2 (en) 1993-10-14
WO1993010121A1 (en) 1993-05-27

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