AU2702984A - Aziridino substituted nitro-imidazoles - Google Patents
Aziridino substituted nitro-imidazolesInfo
- Publication number
- AU2702984A AU2702984A AU27029/84A AU2702984A AU2702984A AU 2702984 A AU2702984 A AU 2702984A AU 27029/84 A AU27029/84 A AU 27029/84A AU 2702984 A AU2702984 A AU 2702984A AU 2702984 A AU2702984 A AU 2702984A
- Authority
- AU
- Australia
- Prior art keywords
- imidazoles
- substituted nitro
- aziridino
- aziridino substituted
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
A compound of formula I <IMAGE> I in which formula: R1 represents hydrogen or an alkyl group; R2-R5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; and n is 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8215545 | 1982-05-27 | ||
GB8231107 | 1982-11-01 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU78669/87A Division AU603380B2 (en) | 1982-05-27 | 1987-09-18 | Compounds useful in the synthesis of 1-aziridinoalkyl nitroimidazoles |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2702984A true AU2702984A (en) | 1985-10-24 |
AU567338B2 AU567338B2 (en) | 1987-11-19 |
Family
ID=26282973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU27029/84A Ceased AU567338B2 (en) | 1982-05-27 | 1984-04-17 | Aziridino substituted nitro-imidazoles |
Country Status (7)
Country | Link |
---|---|
US (4) | US4631289A (en) |
EP (1) | EP0095906B1 (en) |
JP (1) | JPH0649697B2 (en) |
AT (1) | ATE23041T1 (en) |
AU (1) | AU567338B2 (en) |
DE (1) | DE3367092D1 (en) |
GB (1) | GB2123816B (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4815447A (en) * | 1985-03-19 | 1989-03-28 | Mills Randell L | Mossbauer cancer therapy |
CA1329206C (en) * | 1987-06-10 | 1994-05-03 | Tsutomu Kagiya | Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same |
US5304654A (en) * | 1987-06-10 | 1994-04-19 | Yasunori Nishijima | Fluorine-containing nitroimidazole compounds |
US4797397A (en) * | 1987-07-31 | 1989-01-10 | Warner-Lambert Company | 2-nitroimidazole derivatives useful as radiosensitizers for hypoxic tumor cells |
ATE129703T1 (en) * | 1987-12-04 | 1995-11-15 | British Tech Group | NITRO SUBSTITUTED AROMATIC AND HETEROAROMATIC COMPOUNDS FOR CANCER TREATMENTS. |
GB8728418D0 (en) * | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
US5177075A (en) * | 1988-08-19 | 1993-01-05 | Warner-Lambert Company | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process |
US5073639A (en) * | 1988-11-25 | 1991-12-17 | Warner-Lambert Company | Process for the synthesis of novel and known nitroimidazoles which are useful as sensitizing agents |
US5036089A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | 2-oxazolidinone derivatives of nitroimidazoles and pharmaceutical compositions useful as sensitizing agents |
US5036096A (en) * | 1988-11-25 | 1991-07-30 | Warner-Lambert Company | Aziridino derivatives of nitroimidazoles and pharmaceutical compositions of selected derivatives |
US4954515A (en) * | 1988-11-25 | 1990-09-04 | Warner-Lambert Company | Haloalkylaminomethyl-2-nitro-1H-imidazoles |
ATE127018T1 (en) * | 1992-03-06 | 1995-09-15 | Fiutowski Zdzislaw | PHARMACEUTICAL COMPOSITION WITH ANTIVIRAL AND ANTIBACTERIAL ACTION. |
MX9304399A (en) * | 1992-07-31 | 1994-02-28 | Warner Lambert Co | NOVEL PROCESS TO PREPARE [[2-BROMOETHYL) -AMINO] METHYL] -2-NITRO-1H-IMIDAZOL-1-ETHANOL CHIRAL AND RELATED COMPOUNDS. |
US6403359B1 (en) | 1998-09-25 | 2002-06-11 | V. I. TECHNOLOGIES, Inc. | Solid phase quenching systems |
US6617100B2 (en) * | 1998-09-25 | 2003-09-09 | V.I. Technologies, Inc. | Solid phase quenching systems |
US6794518B1 (en) | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
AU2001270025B2 (en) * | 2000-06-21 | 2005-08-18 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals for use in combination therapy |
US7842278B2 (en) * | 2006-10-27 | 2010-11-30 | Natural Pharmacia International, Inc. | Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof |
US20110118191A1 (en) * | 2009-11-14 | 2011-05-19 | Reid Paul F | Crotoxin Administration for Cancer Treatment and Pain Relief |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE47132B1 (en) * | 1977-08-19 | 1983-12-28 | Roche Products Ltd | Novel nitroimidazoles and pharmaceutical preparations containing these as well as their manufacture |
US4282232A (en) * | 1979-04-26 | 1981-08-04 | Research Corporation | Nitroimidazole radiosensitizers for hypoxic tumor cells and compositions thereof |
-
1983
- 1983-05-27 US US06/498,827 patent/US4631289A/en not_active Expired - Lifetime
- 1983-05-27 JP JP58094752A patent/JPH0649697B2/en not_active Expired - Lifetime
- 1983-05-27 AT AT83303063T patent/ATE23041T1/en not_active IP Right Cessation
- 1983-05-27 US US06/498,826 patent/US4581368A/en not_active Expired - Lifetime
- 1983-05-27 GB GB08314696A patent/GB2123816B/en not_active Expired
- 1983-05-27 DE DE8383303063T patent/DE3367092D1/en not_active Expired
- 1983-05-27 EP EP83303063A patent/EP0095906B1/en not_active Expired
-
1984
- 1984-04-17 AU AU27029/84A patent/AU567338B2/en not_active Ceased
-
1985
- 1985-10-28 US US06/792,155 patent/US4596817A/en not_active Expired - Lifetime
-
1986
- 1986-11-10 US US06/929,095 patent/US4757148A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US4596817A (en) | 1986-06-24 |
US4631289A (en) | 1986-12-23 |
US4757148A (en) | 1988-07-12 |
JPS58225086A (en) | 1983-12-27 |
GB2123816A (en) | 1984-02-08 |
ATE23041T1 (en) | 1986-11-15 |
EP0095906A1 (en) | 1983-12-07 |
GB2123816B (en) | 1986-03-19 |
AU567338B2 (en) | 1987-11-19 |
EP0095906B1 (en) | 1986-10-22 |
GB8314696D0 (en) | 1983-07-06 |
DE3367092D1 (en) | 1986-11-27 |
US4581368A (en) | 1986-04-08 |
JPH0649697B2 (en) | 1994-06-29 |
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