AU2698997A - Agent for inhibiting leukocyte invasion of tissues - Google Patents

Agent for inhibiting leukocyte invasion of tissues

Info

Publication number
AU2698997A
AU2698997A AU26989/97A AU2698997A AU2698997A AU 2698997 A AU2698997 A AU 2698997A AU 26989/97 A AU26989/97 A AU 26989/97A AU 2698997 A AU2698997 A AU 2698997A AU 2698997 A AU2698997 A AU 2698997A
Authority
AU
Australia
Prior art keywords
atoms
agent
tissues
invasion
inhibiting leukocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU26989/97A
Inventor
Kay Brune
Rupert Hallmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chephasaar Chem-Pharm Fabrik GmbH
Original Assignee
CHEPHASAAR GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19616581A external-priority patent/DE19616581C2/en
Application filed by CHEPHASAAR GmbH filed Critical CHEPHASAAR GmbH
Publication of AU2698997A publication Critical patent/AU2698997A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

An agent for inhibiting leukocyte invasion of tissues contains a hydroxyproline derivative of formula (I), in which R1 and R2 may be the same or different and stand for hydrogen, alkyl groups with 1 to 10 C atoms or an acyl group with 1 to 8 C atoms, R3 stands for a hydroxy, alkoxy or amino group which may have 1 or 2 alkyl substituents with 1 to 4 C atoms or 1 or 2 aryl substituents with 6 to 10 C atoms. Also disclosed is a pharmaceutically acceptable salt of this compound, optionally with other usual pharmaceutical additives and/or auxiliary substances. This agent is useful to prevent and heal damages to tissues caused by invasion and activation of leukocytes.
AU26989/97A 1996-04-16 1997-04-16 Agent for inhibiting leukocyte invasion of tissues Abandoned AU2698997A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19614919 1996-04-16
DE19614919 1996-04-16
DE19616581 1996-04-25
DE19616581A DE19616581C2 (en) 1996-04-16 1996-04-25 Use of oxaceprol to treat reperfusion damage
PCT/EP1997/001909 WO1997038690A1 (en) 1996-04-16 1997-04-16 Agent for inhibiting leukocyte invasion of tissues

Publications (1)

Publication Number Publication Date
AU2698997A true AU2698997A (en) 1997-11-07

Family

ID=26024771

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26989/97A Abandoned AU2698997A (en) 1996-04-16 1997-04-16 Agent for inhibiting leukocyte invasion of tissues

Country Status (8)

Country Link
EP (1) EP0906096B1 (en)
JP (1) JPH11510515A (en)
AT (1) ATE219671T1 (en)
AU (1) AU2698997A (en)
CZ (1) CZ330498A3 (en)
NO (1) NO984784L (en)
PL (1) PL329331A1 (en)
WO (1) WO1997038690A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202008018253U1 (en) 2007-02-22 2012-05-21 Beiersdorf Ag Cosmetic and pharmaceutical applications of N-acetylhydroxyproline
CL2008001640A1 (en) * 2007-06-08 2008-11-07 Bergen Teknologioverforing As Use of hydroxyproline to prepare an alloy composition intended to promote the growth of an animal, such as fish, birds and mammals.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795327C3 (en) * 1967-09-14 1979-09-13 S.A.R.L. Franco-Chimie, Paris Use of N-acetyl-1-hydroxyproline
US3932638A (en) * 1967-09-14 1976-01-13 Franco-Chimie S.A.R.L. Compositions and methods for wound healing
CA1281288C (en) * 1984-11-05 1991-03-12 Wilhelm Hoerrmann Tumor therapy
IT1248669B (en) * 1990-05-30 1995-01-26 Pulitzer Italiana HYDROXYPROLINE DERIVATE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT
JPH05130883A (en) * 1991-11-13 1993-05-28 Kyowa Hakko Kogyo Co Ltd Production of trans-l-hydroxyproline

Also Published As

Publication number Publication date
EP0906096A1 (en) 1999-04-07
NO984784D0 (en) 1998-10-14
WO1997038690A1 (en) 1997-10-23
NO984784L (en) 1998-10-14
JPH11510515A (en) 1999-09-14
ATE219671T1 (en) 2002-07-15
CZ330498A3 (en) 1999-07-14
PL329331A1 (en) 1999-03-29
EP0906096B1 (en) 2002-06-26

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