AU2665999A - A valveless gas chromatographic system with pulsed injection and temperature programmed elution - Google Patents
A valveless gas chromatographic system with pulsed injection and temperature programmed elutionInfo
- Publication number
- AU2665999A AU2665999A AU26659/99A AU2665999A AU2665999A AU 2665999 A AU2665999 A AU 2665999A AU 26659/99 A AU26659/99 A AU 26659/99A AU 2665999 A AU2665999 A AU 2665999A AU 2665999 A AU2665999 A AU 2665999A
- Authority
- AU
- Australia
- Prior art keywords
- molecules
- interest
- port
- gas column
- vapor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000002347 injection Methods 0.000 title claims description 22
- 239000007924 injection Substances 0.000 title claims description 22
- 238000010828 elution Methods 0.000 title description 3
- 239000007789 gas Substances 0.000 claims description 28
- 238000005070 sampling Methods 0.000 claims description 16
- 238000004458 analytical method Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 238000003795 desorption Methods 0.000 claims description 13
- 239000012159 carrier gas Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 11
- 238000001514 detection method Methods 0.000 claims description 8
- 238000013375 chromatographic separation Methods 0.000 claims 2
- 239000002360 explosive Substances 0.000 description 7
- 238000004817 gas chromatography Methods 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000008246 gaseous mixture Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000004081 narcotic agent Substances 0.000 description 2
- 238000010223 real-time analysis Methods 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000599 controlled substance Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000005264 electron capture Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0606—Investigating concentration of particle suspensions by collecting particles on a support
- G01N15/0637—Moving support
- G01N15/0643—Moving support of the filter type
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/30—Control of physical parameters of the fluid carrier of temperature
- G01N2030/3053—Control of physical parameters of the fluid carrier of temperature using resistive heating
- G01N2030/3061—Control of physical parameters of the fluid carrier of temperature using resistive heating column or associated structural member used as heater
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N2030/621—Detectors specially adapted therefor signal-to-noise ratio
- G01N2030/623—Detectors specially adapted therefor signal-to-noise ratio by modulation of sample feed or detector response
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Description
WO99/40422 PCT/US99/02777 A VALVELESS GAS CHROMATOGRAPHIC SYSTEM WITH PULSED INJECTION AND TEMPERATURE PROGRAMMED ELUTION 5 CROSS-REFERENCE TO RELATED APPLICATIONS The following patent application is based on and claims the benefit of U.S. Provisional Patent Application Serial No. 60/074,195 filed February 10, 1998. 10 DESCRIPTION Field of the Invention The present invention relates generally to detection 15 and analysis of gaseous components and more particularly to a valveless system using gas chromatography with pulsed injection and temperature programmed elution. Background of the Invention 20 Gas chromatography is an established analytical technique for separating the components of a gaseous mixture as the mixture flows through a tubular column. There are many different ways of injecting the initial 25 sample into the column and performing the separation. For example, one known method of carrying out the separation in open tubular columns is shown in Figures la and lb. In this method, valve 1 admits a small volume of the sample flowing through the loop 2 into the column 3 30 when the valve is switched from the sampling position shown in Figure la to the injection position shown in Figure lb. This volume of sample is then carried down WO99/40422 PCT/US99/02777 the column by a flow of carrier gas through the port 4 and 5 of the valve and separated into its components when it interacts with the column wall coated with the appropriate separating medium. The net result is that 5 the components exit the column as separate volumes at different times. The time between the injection and the exit of a component is called its retention time. The components are detected by an appropriate detection system, for example, an electron capture detector (ECD) 10 or a thermal conductivity detector. The signal generated by the detector (the chromatogram) can then be plotted out for analysis. The speed at which analysis takes place in this system is dependent on several factors including the type 15 and length of the column, its temperature and the velocity of the carrier gas in the column. In general total analysis times are in the order of minutes to hours. Sample preparation and injection can take several minutes to hours depending on the nature of the sample. 20 Thus for real time analysis this process needs to be speeded up considerably. Real time analysis is highly desirable when using the technique of gas chromatography for quickly detecting and identifying compounds contained in narcotics and 25 explosives. Then sampling and detection systems based on gas chromatography can be used for checking suspicious objects which could contain explosive devices or controlled drugs and narcotics. Such devices are useful at border crossings and airports for identifying and 30 preventing drug smuggling or terrorist activity. Therefore, it is also highly desirable to make such detection system portable and operable in real time. -2- WO99/40422 PCT/US99/02777 Moreover, it is also desirable to make such systems battery operable. Gas chromatography of drug or explosive samples require that the sampling separation systems work at high temperatures typically in the region 5 of 100 to 300 degrees Celsius. Presently, there are no energy efficient or portable GC-IMS devices which can operate in the high temperature regime for analyzing drugs or explosives because power requirements for gas chromatography systems usually preclude battery operated 10 portable systems of practical size and weight. Therefore, it is also highly desirable to have a gas chromatography system with minimum power consumption without sacrificing performance. 15 Summary of the Invention The present invention provides a novel design and method of operation for a pulsed high speed sampling and gas chromatographic (GC) separation system which is 20 capable of sampling and analyzing particles and vapors containing drug and explosive residues in less than twenty seconds and which at the same time consume very little power. The speed and power savings provided by the present invention uses a heat-on-demand (HOD) 25 technology explained below. There are several important advantages for using the pulsed analysis technique in simple, portable, low power GC-IMS sample gathering and analytical system as disclosed by the present invention. Because of the 30 pulsed nature of the system, power consumption takes place only when the system is analyzing, greatly increasing the overall energy efficiency of the system -3- WO99/40422 PCT/US99/02777 compared to static systems where the components are always maintained at high operating temperatures. This makes its use practical in hand-held analytical devices using batteries as power sources. 5 Moreover, the pulsed heating sequence avoids the use of valves to switch a sample packet into the column as is done in static high temperature systems, making the system simpler and more reliable. Advantageously, the system of the present invention 10 may operate as one integrated system for sample gathering, analysis, and data presentation, thus, making it an ideal portable real-time analytical instrument for many applications, including drug and explosive checks and searches at border points, airports, etc., and also 15 for air quality monitoring. Furthermore, the present invention may be used with an ion mobility spectrometer (IMS) device as a second analyzer. Using the IMS greatly increases the overall selectivity and sensitivity of the instrument without 20 adversely affecting its performance or energy efficiency. Further features and advantages of the present invention as well as the structure and operation of various embodiments of the present invention are described in detail below with reference to the 25 accompanying drawings. In the drawings, like reference numbers indicate identical or functionally similar elements. Brief Description of the Drawings 30 Preferred embodiments of the present invention will now be described, by way of example only, with reference -4- WO99/40422 PCT/US99/02777 to the accompanying drawings in which: Figures la and lb illustrate an example of separating the components of a gaseous mixture as the mixture flows through a tubular column as known in the 5 prior art systems; Figure 2a illustrates a schematic diagram of the valveless gas chromatographic system of the present invention; and Figure 2b illustrates a graphical representation of 10 the heating and cooling sequence of the present invention. Detailed Description of the Preferred Embodiment of the Invention 15 In the preferred embodiment, the valveless gas chromatographic system of the present invention is an integrated sampling and analysis device. Such integration with an analysis device makes it possible to 20 use the system as a portable, hand-held device. A description of the hand-held device which integrates the system of the present invention can be found in the related and commonly owned PCT Application No. PCT/US98/22092 entitled A SAMPLE TRAPPING ION MOBILITY 25 SPECTROMETER FOR PORTABLE MOLECULAR DETECTION, filed on October 20, 1998, the description of which is fully incorporated herein by reference thereto. Figure 2a shows a schematic diagram of the system of the present invention. The system may be divided into a 30 sampling section and analysis section. The system includes a sample trap having a ribbon about half an inch wide wound on bobbins 201 and 202 and passing between the -5- WO 99/40422 PCT/US99/02777 sampling and analysis sections. The material used to make the ribbon may be a metallic mesh typically of size 400 or more or other porous type which allows air to pass through freely but traps small particles and vapors. The 5 vapor trapping or collecting ability may be increased by coating the ribbon with an absorbing media known in the art for use in absorbing the desired molecules of interest. A nozzle 203 and a pump tube 204 are cylindrical 10 entities with soft 0 ring seals at the ends that are closer to the ribbon. When the machine is in the sampling mode, 203 and 204 form a tight seal on portion 205 of the ribbon. A vacuum pump attached to the pump tube 204 sucks vapors and/or particles through the 15 sampling nozzle 203 onto the sampling area 205 of the ribbon. After a predetermined time duration of sampling, e.g., few seconds of sampling, the nozzle 203 and the pump tube 204 are moved away from the ribbon to break the seal. The moving process is accomplished with the aid of 20 electric motors controlled by a computer 410. After the seal is broken, the ribbon is moved in the direction shown by the arrow 220 to the location at 206. The movement of the ribbon is also accomplished with the aid of electric motors and position sensors which stop the 25 motors after positioning the sample. Once at position 206, the desorption port 207 and the injection port 208 move towards the ribbon under motor control and form an air-tight seal around 206. The desorption port 207 is a cylindrical entity less than 30 1/4" in diameter, and may include a built-in electric heater 210 to heat the gas passing through the ribbon to a temperature of 200 Celsius or more within a few -6- WO99/40422 PCTUS99/02777 seconds. A carrier gas flows into 207 and gets heated by the heaters so that when the hot gas exits out of the desorption port 207 and impinges on portion 206 of the ribbon, it in turn heats the sample trapped in the ribbon 5 at 206. The rate of flow of the carrier gas is typically about 50 to 200 cc/min. At the time the desorption port 207 is hot, the injection port 208 is also heated to the same temperature using the same technique as for the desorption port 207 10 with the aid of electric heater 211. The injection port 208 has a more complex construction because it has the gas chromatographic column 209 attached in a unique manner. The column 209 in the preferred embodiment has a metallic jacket which is directly heated by passing a 15 current through it from a controlled source 212. Portion 209a of the column 209 is inside the injection port 208 and portion 209b is outside the injection port 208. The far end of 209b is connected to the detector 213. This detector 213 is preferably an IMS detector. The carrier 20 gas flowing into the injection port 208 goes directly into portion 209a of the column and thence into portion 209b. When the desorption port 207 and the injection port 208 are heated, the column 209 is not heated. This causes the vapors of the trapped sample at 206 which are 25 released by the hot carrier gas to move through portion 209a of the column and condense at the beginning of portion 209b of the column. Once the sample has settled down in the front end of the column 209, the heaters 210 and 211 are switched off, 30 typically by a computer controller 410. The temperatures of the heaters rapidly drop to ambient in a few seconds because the ports 207, 208 are constructed with the -7- WO99/40422 PCT/US99/02777 minimum amount of heat capacity. The computer 410 senses the temperature of the ports 207, 208 and when they have reached an appropriate minimum value which is preferably about 20 degrees Celsius above the ambient, the computer 5 410 turns on the heater 212. This causes the column portions 209a, 209b to heat up rapidly from ambient to more than 200 degrees Celsius in a few seconds. The rate of this heating is controlled by the computer program. Since there is a carrier gas flow in the column during 10 the heating cycle, the condensed compounds move down the column and separate into the individual components and exit into the IMS 213 at different times. The IMS ionizes these packets of individual components in the sample and further separate the components according to 15 their mobility in the drift gas flowing in the IMS. The individual ion packets are then collected on an electrode and amplified electronically by amplifier 214 for further signal processing and display 215 using the computer 410. It should be noted that detection devices other than IMS 20 may be used, e.g., by attaching a different detection device at the end of the column 209. The sequence of heating and cooling of the analysis system is critical to the success of the device as a programmed pulsed gas chromatographic system. A 25 graphical representation of the heating and cooling sequence is shown in Figure 2b where the horizontal axis is the time axis common to the three graphs. The three separate vertical axes are the temperature axes. The maximum values of the temperatures depend on the nature 30 of the compounds being analyzed, and are typically around 200 degrees Celsius for explosive and drug compounds. The rate of rise and fall of the temperature programming -8- WO99/40422 PCT/US99/02777 of the column is in general constant, but can be changed to follow a desired curve using the computer 410 to control the duty cycle of the heater. As shown in Figure 2b, there is no delay between the heating cycles 240, 250 5 of the heaters in the ports 207, 208, but the column heating starts as shown at 260 after these heaters have cooled down, to achieve the desired effect described above. In addition, the heated portions have low heat 10 capacities and are designed to dissipate the heat efficiently. Such a design is important for achieving fast analysis times. With the system of the present invention as described above, the ports 207, 208 and the column 109 can be heated and cooled over the working 15 range in a few seconds. While the invention has been particularly shown and described with respect to a preferred embodiment thereof, it will be understood by those skilled in the art that the foregoing and other changes in form and details may 20 be made therein without departing from the spirit and scope of the invention. -9-
Claims (17)
1. A high speed sampling and gas chromatographic separation system which is capable of sampling and analyzing molecules of interest, the system comprising: an input device for collecting sample particles having the molecules of interest at a first position; a port device capable of being heated by a heat pulse, the port device connected to the input device to receive the sample particles having the molecules of interest at a second position, the molecules of interest releasing a vapor in response to the heat pulse applied to the port device; and a gas column device connected to the port device, the gas column device receiving the vapor, the gas column device having a temperature lower than the port device, wherein the vapor is condensed in the gas column device, the gas column device further capable of being heated by a heat pulse, wherein in response to the heat pulse applied to the gas column, the condensed vapor of the molecules of interest separate into individual components and exit the gas column at different times.
2. The system as claimed in claim 1, wherein the system further includes: a detector connected to the gas column, the detector receiving the individual components of the condensed vapor, the detector for analyzing the molecules of interest.
-10-
3. The system as claimed in claim 1, wherein the port device includes : a desorption port for receiving a carrier gas, the desorption port capable of being heated by a heat pulse and further heating the carrier gas in response to the heat pulse; and an injection port positioned to receive the carrier gas from the desorption port, the injection port capable of being heated by a heat pulse, wherein the molecules of interest is positioned between the desorption port and the injection port, the sample particles having the molecules of interest being heated as the heated carrier gas exits the desorption port and enters the injection port, the heated carrier gas further causing the molecules of interest to release a vapor into the injection port.
4. The system as claimed in claim 3, wherein the gas column device has a first portion and a second portion, the first portion positioned inside the injection port, the second portion positioned outside the injection port, wherein the carrier gas carrying the vapor of the molecules of interest is transported from the first portion to the second portion.
5. The system as claimed in claim 4, wherein the system further includes: a detector connected to the second portion, the detector receiving and ionizing the vapor of the molecules of interest into ionized components for analysis .
-11-
6. The system as claimed in claim 5, wherein the system further includes: an amplifier connected to the detector for amplifying signals generated by the ionized components for further signal processing.
7. The system as claimed in claim 6, wherein the system further includes an output device for presenting the signals processed to a user.
8. The system as claimed in claim 1, wherein the gas column further includes a metallic jacket capable OJ. being directly heated by passing a current through the metallic jacket.
9. The system as claimed in claim 3, wherein the system further includes a first heater capable of transmitting pulsed heat to the desorption port.
10. The system as claimed in claim 3, wherein the system further includes a second heater capable of transmitting pulsed heat to the injection port.
11. The system as claimed in claim 3, wherein the system further includes a third heater capable of transmitting pulsed heat to the gas column.
12. The system as claimed in claim 3, wherein the system further includes: a nozzle for inputting the sample particles having the molecules of interest to be collected and
-12- vaporized for detection, the nozzle having a first end where the sample having the molecules of interest are inputted, the nozzle further having a second end; a pump tube attachable to the second end of the nozzle; and a ribbon passing between the nozzle and the pump tube, the ribbon for collecting the sample particles having the molecules of interest at the first position, wherein the sample particles having the molecules of interest are sucked through the nozzle onto the ribbon by the pump tube, the ribbon having the sample particles having the molecules of interest further moved along to be positioned between the desorption port and the injection port at the second position.
13. The system as claimed in claim 12, wherein the ribbon is a porous type.
14. The system as claimed in claim 12, wherein the ribbon is a metallic mesh.
15. A method for high speed sampling and analysis of molecular components in a gas chromatographic separation system, the method comprising: receiving sample particles having molecules of interest at a port device; heating the port device with a heat pulse to a selected temperature to transform the molecules of interest into a vapor; moving the vapor to a gas column device having a temperature less than the port device; condensing the vapor in the gas column device;
-13- and heating the gas column device with a heat pulse to a predetermined temperature to cause the vapor to separate into individual components and exit the gas column at different times.
16. The method as claimed in claim 15, wherein the method further includes : receiving the individual components into a detector device when the individual components exit the gas column device.
17. The method as claimed in claim 15, wherein the method further includes : collecting the sample particles having the molecules of interest onto a ribbon from an input nozzle before the step of receiving.
-14-
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7419598P | 1998-02-10 | 1998-02-10 | |
US60074195 | 1998-02-10 | ||
PCT/US1999/002777 WO1999040422A1 (en) | 1998-02-10 | 1999-02-10 | A valveless gas chromatographic system with pulsed injection and temperature programmed elution |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2665999A true AU2665999A (en) | 1999-08-23 |
Family
ID=22118254
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU26659/99A Abandoned AU2665999A (en) | 1998-02-10 | 1999-02-10 | A valveless gas chromatographic system with pulsed injection and temperature programmed elution |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1062504A4 (en) |
JP (1) | JP2002502970A (en) |
CN (1) | CN1296565A (en) |
AU (1) | AU2665999A (en) |
CA (1) | CA2320445A1 (en) |
WO (1) | WO1999040422A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004053477A1 (en) * | 2002-12-10 | 2004-06-24 | Honeywell International Inc. | Phased micro analyzer |
DE102008037416B3 (en) * | 2008-10-06 | 2010-03-11 | Joint Analytical Systems Gmbh | Transfer unit for analyzers |
JP2012132781A (en) * | 2010-12-21 | 2012-07-12 | Taiyo Nippon Sanso Corp | Analytical method using gas chromatography and analyzer using gas chromatography |
CN103335924A (en) * | 2012-12-10 | 2013-10-02 | 江苏天瑞仪器股份有限公司 | Atmospheric heavy-metal on-line analyzer |
CN103399075B (en) * | 2013-07-25 | 2015-06-17 | 中国科学院生态环境研究中心 | Double-mode detecting method and kit for detecting for organic explosive residues |
JP2023074856A (en) * | 2021-11-18 | 2023-05-30 | 株式会社島津製作所 | Gas chromatography device |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3768300A (en) * | 1971-09-24 | 1973-10-30 | Vacuum Inst Corp | Differential sorption chromatograhy |
CA997169A (en) * | 1973-10-01 | 1976-09-21 | John L. Brokenshire | Detector for a trace of a specific vapour in the atmosphere |
US4551848A (en) * | 1981-12-10 | 1985-11-05 | Mount Isa Mines Limited | Lead-in-air monitor |
US5551278A (en) * | 1987-07-08 | 1996-09-03 | Thermedics Inc. | Vapor collector/desorber with non-conductive tube bundle |
US5268302A (en) * | 1990-05-29 | 1993-12-07 | Thermedics Inc. | Selective, high speed detection of vapors with analysis of multiple GC-separated portions |
US5135549A (en) * | 1991-01-30 | 1992-08-04 | The Board Of Trustees Of Southern Illinois University | Chromatographic technique and apparatus |
DE4419596C1 (en) * | 1994-06-03 | 1995-06-01 | Gerstel Gmbh | Thermodesorption device for gas chromatograph |
WO1996000388A2 (en) * | 1994-06-24 | 1996-01-04 | Universite De Montreal | Selective removal of volatile substances injected into a chromatographic packing filled column |
-
1999
- 1999-02-10 WO PCT/US1999/002777 patent/WO1999040422A1/en not_active Application Discontinuation
- 1999-02-10 EP EP99906839A patent/EP1062504A4/en not_active Withdrawn
- 1999-02-10 CA CA002320445A patent/CA2320445A1/en not_active Abandoned
- 1999-02-10 JP JP2000530785A patent/JP2002502970A/en active Pending
- 1999-02-10 AU AU26659/99A patent/AU2665999A/en not_active Abandoned
- 1999-02-10 CN CN 99804928 patent/CN1296565A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO1999040422A1 (en) | 1999-08-12 |
EP1062504A1 (en) | 2000-12-27 |
EP1062504A4 (en) | 2001-02-14 |
JP2002502970A (en) | 2002-01-29 |
CA2320445A1 (en) | 1999-08-12 |
CN1296565A (en) | 2001-05-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6481263B1 (en) | Hand-held detection system using GC/IMS | |
JP2814304B2 (en) | Banned product detection device | |
US9612228B2 (en) | Method and apparatus for inspecting a gas sample | |
US8161830B2 (en) | Method, apparatus, and system for integrated vapor and particulate sampling | |
EP2260285B1 (en) | Hand-held trace vapor/particle detection system | |
CA2306761A1 (en) | A sample trapping ion mobility spectrometer for portable molecular detection | |
AU2665999A (en) | A valveless gas chromatographic system with pulsed injection and temperature programmed elution | |
US11709149B2 (en) | Cold trap enhanced input into low-cost analyzer | |
Stott et al. | High-throughput real-time chemical contraband detection | |
GB2618073A (en) | Detector inlet and method | |
WO2024115893A1 (en) | Detector inlet apparatus and method | |
JPH1010101A (en) | Pre-concentrator collector for detecting minute amount of gaseous chemical substance |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |