AU2646192A - (lactobacilli) having genetically modified bile salt hydrolytic activity, production and use thereof - Google Patents

(lactobacilli) having genetically modified bile salt hydrolytic activity, production and use thereof

Info

Publication number
AU2646192A
AU2646192A AU26461/92A AU2646192A AU2646192A AU 2646192 A AU2646192 A AU 2646192A AU 26461/92 A AU26461/92 A AU 26461/92A AU 2646192 A AU2646192 A AU 2646192A AU 2646192 A AU2646192 A AU 2646192A
Authority
AU
Australia
Prior art keywords
lactobacilli
production
genetically modified
bile salt
hydrolytic activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU26461/92A
Inventor
Harry Christiaens
Rob Leer
Mark Posno
Willy Verstraete
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universiteit Gent
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Publication of AU2646192A publication Critical patent/AU2646192A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU26461/92A 1991-09-11 1992-09-11 (lactobacilli) having genetically modified bile salt hydrolytic activity, production and use thereof Abandoned AU2646192A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL9101537A NL9101537A (en) 1991-09-11 1991-09-11 LACTOBACILLI WITH GENETICALLY MODIFIED GAL SALT HYDROLYTIC ACTIVITY, PRODUCTION AND USE THEREOF.
NL9101537 1991-09-11

Publications (1)

Publication Number Publication Date
AU2646192A true AU2646192A (en) 1993-04-05

Family

ID=19859689

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26461/92A Abandoned AU2646192A (en) 1991-09-11 1992-09-11 (lactobacilli) having genetically modified bile salt hydrolytic activity, production and use thereof

Country Status (3)

Country Link
AU (1) AU2646192A (en)
NL (1) NL9101537A (en)
WO (1) WO1993005161A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2992945B2 (en) * 1994-03-11 1999-12-20 カルピス株式会社 Lactobacillus acidophilus lactic acid bacteria
EP0792586A3 (en) * 1996-02-28 1999-04-07 Unilever N.V. Food products containing bacteria with cholesterol lowering activity
US7939061B2 (en) 2003-02-28 2011-05-10 Micropharma Limited Cell and enzyme compositions for modulating bile acids, cholesterol and triglycerides
EP3067056A1 (en) 2009-05-01 2016-09-14 UAS Laboratories LLC Bacterial compositions for prophylaxis and treatment of degenerative disease
CN101948857B (en) * 2010-08-16 2013-02-13 中国农业大学 Recombinant lactobacillus casei engineering strain and preparation method thereof
CN103992991B (en) * 2013-11-11 2016-06-29 江南大学 A kind of bile salt hydrolase mutant and application thereof
WO2016210384A2 (en) 2015-06-25 2016-12-29 Synlogic, Inc. Bacteria engineered to treat metabolic diseases
WO2017123592A1 (en) * 2016-01-11 2017-07-20 Synlogic, Inc. Bacteria engineered to treat disorders associated with bile salts
CN105524907B (en) * 2016-02-01 2018-12-04 江南大学 A kind of bile salt hydrolase mutant that Substratspezifitaet improves

Also Published As

Publication number Publication date
WO1993005161A1 (en) 1993-03-18
NL9101537A (en) 1993-04-01

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