AU2578588A - Esters of pharmacologically active carboxylic acids - Google Patents

Esters of pharmacologically active carboxylic acids

Info

Publication number
AU2578588A
AU2578588A AU25785/88A AU2578588A AU2578588A AU 2578588 A AU2578588 A AU 2578588A AU 25785/88 A AU25785/88 A AU 25785/88A AU 2578588 A AU2578588 A AU 2578588A AU 2578588 A AU2578588 A AU 2578588A
Authority
AU
Australia
Prior art keywords
esters
carboxylic acids
pharmacologically active
active carboxylic
pharmacologically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU25785/88A
Other versions
AU614793B2 (en
Inventor
Andre Furlenmeier
Christian Hubschwerlen
Marc Montavon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2578588A publication Critical patent/AU2578588A/en
Application granted granted Critical
Publication of AU614793B2 publication Critical patent/AU614793B2/en
Assigned to F. HOFFMANN-LA ROCHE AG reassignment F. HOFFMANN-LA ROCHE AG Alteration of Name(s) in Register under S187 Assignors: F. HOFFMANN-LA ROCHE AG
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
AU25785/88A 1987-11-24 1988-11-21 Esters of pharmacologically active carboxylic acids Ceased AU614793B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH457087 1987-11-24
CH4570/87 1987-11-24
CH316588 1988-08-25
CH3165/88 1988-08-25

Publications (2)

Publication Number Publication Date
AU2578588A true AU2578588A (en) 1989-05-25
AU614793B2 AU614793B2 (en) 1991-09-12

Family

ID=25692354

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25785/88A Ceased AU614793B2 (en) 1987-11-24 1988-11-21 Esters of pharmacologically active carboxylic acids

Country Status (14)

Country Link
EP (1) EP0318767A3 (en)
JP (1) JPH01165585A (en)
KR (1) KR890008082A (en)
AU (1) AU614793B2 (en)
DK (1) DK637888A (en)
FI (1) FI885330A (en)
HU (1) HU207522B (en)
IL (1) IL88403A0 (en)
MC (1) MC1991A1 (en)
NO (1) NO885221L (en)
NZ (1) NZ226989A (en)
PT (1) PT89080B (en)
SU (1) SU1598880A3 (en)
YU (2) YU216188A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU654300B2 (en) * 1990-11-09 1994-11-03 Eisai Co. Ltd. 7-acyl-3-(substituted carbamoyloxy)cephem compounds and process for their preparation

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990008354A (en) * 1995-05-03 1999-01-25 페터 죤 기딩스 Ester of carbapenem
CN103945869A (en) * 2011-08-31 2014-07-23 马林克罗特有限公司 Remote assembly of targeted nanoparticles using H-phosphonate-ene/-yne hydrophosphonylation reactions
EP2753326A4 (en) 2011-09-09 2015-04-15 Cubist Pharm Inc Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
CN110279698B (en) 2013-03-15 2022-10-28 默沙东有限责任公司 Ceftolozane antibiotic compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2476087A1 (en) * 1980-02-18 1981-08-21 Roussel Uclaf NOVEL OXIMES DERIVED FROM 3-ALKYLOXY OR 3-ALKYL-THIOMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
JPS5984889A (en) * 1982-11-05 1984-05-16 Sumitomo Chem Co Ltd Cephalosporin derivative and its preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU654300B2 (en) * 1990-11-09 1994-11-03 Eisai Co. Ltd. 7-acyl-3-(substituted carbamoyloxy)cephem compounds and process for their preparation

Also Published As

Publication number Publication date
YU191589A (en) 1991-02-28
EP0318767A3 (en) 1991-03-20
SU1598880A3 (en) 1990-10-07
FI885330A (en) 1989-05-25
DK637888A (en) 1989-05-25
HU207522B (en) 1993-04-28
IL88403A0 (en) 1989-06-30
FI885330A0 (en) 1988-11-17
EP0318767A2 (en) 1989-06-07
NO885221L (en) 1989-05-25
NO885221D0 (en) 1988-11-23
YU216188A (en) 1990-04-30
HUT48895A (en) 1989-07-28
PT89080B (en) 1993-04-30
NZ226989A (en) 1992-05-26
MC1991A1 (en) 1989-11-30
DK637888D0 (en) 1988-11-15
AU614793B2 (en) 1991-09-12
KR890008082A (en) 1989-07-08
JPH01165585A (en) 1989-06-29
PT89080A (en) 1988-12-01

Similar Documents

Publication Publication Date Title
AU4596389A (en) Ester production by hydrogenation of carboxylic acids and anhydrides
HU9300776D0 (en) Carboxylic acid esters of rapamycine
EP0302349A3 (en) Biologically active carboxylic acid esters
GB8719886D0 (en) Carboxylic acid esters/acids
AU2578588A (en) Esters of pharmacologically active carboxylic acids
AU572131B2 (en) Production of unsaturated carboxylic acids and/or esters
AU558806B2 (en) Production of carboxylic acids and esters
DE3569931D1 (en) Carboxylic acid ester derivatives of deglucoteicoplanin
AU569584B2 (en) Preparation of carboxylic acids and esters
GB2194944B (en) Preparation of unsaturated carboxylic acid esters
JPS6471838A (en) Manufacture of carboxylic acid ester
GB8722743D0 (en) Preparation of esters of carboxylic acids
AU5882186A (en) 3-(substituted)propenylaminothiazol-ylcephalosporanic acids and esters thereof
HUT39411A (en) Process for producing active esters of carboxylic acids
AU569479B2 (en) Preparation of carboxylic acids and esters
HK85194A (en) Cyclohexyl esters of alpha-fluoro/carboxylic acids
AU1148288A (en) Bicyclic beta-lactam carboxylic acids
EP0512848A3 (en) Enzymatic resolution of alpha-tertiary carboxylic acid esters
AU2426884A (en) Preparation of optically active carboxylic acid esters
AU3602584A (en) Production of carboxylic acids and/or esters
AU2014388A (en) Fluorobenzyl esters of cyclopropane carboxylic acids useful as insecticides
ZA888616B (en) Esters of pharmacologically active carboxylic acids
AU1011488A (en) The production of carboxylic acids and esters thereof
GB8803535D0 (en) Process for preparation of carboxylic acids/esters thereof
AU1283488A (en) Aqueous-dispersed polymer compositions containing cyanoalkyl esters of unsaturated carboxylic acids