AU2503099A - Method for producing a factor viii/von willebrand factor complex - Google Patents

Method for producing a factor viii/von willebrand factor complex

Info

Publication number
AU2503099A
AU2503099A AU25030/99A AU2503099A AU2503099A AU 2503099 A AU2503099 A AU 2503099A AU 25030/99 A AU25030/99 A AU 25030/99A AU 2503099 A AU2503099 A AU 2503099A AU 2503099 A AU2503099 A AU 2503099A
Authority
AU
Australia
Prior art keywords
von willebrand
factor
producing
complex
factor viii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU25030/99A
Inventor
Yendra Dr. Linnau
Wolfgang Schonhofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter AG
Original Assignee
Baxter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/AT1998/000043 external-priority patent/WO1998038220A1/en
Application filed by Baxter AG filed Critical Baxter AG
Publication of AU2503099A publication Critical patent/AU2503099A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention relates to a method for the production of factor VIII:C/von Willebrand factor complex from plasma or a plasma fraction by chromatography in a cation exchanger, wherein the factor VIII:C/von Willebrand factor complex is obtained with at least 300 times the purity of the plasma and the yield of factor VIII:C and the von Willebrand factor is at least 50 % in relation to cryoprecipitates or analogous plasma fractions.
AU25030/99A 1998-02-27 1999-02-25 Method for producing a factor viii/von willebrand factor complex Abandoned AU2503099A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
WOAT9800043 1998-02-27
PCT/AT1998/000043 WO1998038220A1 (en) 1997-02-27 1998-02-27 Method for purifying factor viii/vwf complex by cation-exchange chromatography
AT0086698A AT408443B (en) 1998-02-27 1998-05-20 METHOD FOR OBTAINING PURIFIED FACTOR VIII: C / VWF COMPLEX
AT866/98 1998-05-20
PCT/AT1999/000048 WO1999043712A1 (en) 1998-02-27 1999-02-25 Method for producing a factor viii/von willebrand factor complex

Publications (1)

Publication Number Publication Date
AU2503099A true AU2503099A (en) 1999-09-15

Family

ID=25594143

Family Applications (1)

Application Number Title Priority Date Filing Date
AU25030/99A Abandoned AU2503099A (en) 1998-02-27 1999-02-25 Method for producing a factor viii/von willebrand factor complex

Country Status (6)

Country Link
EP (1) EP1056779B1 (en)
JP (1) JP2002504561A (en)
AT (2) AT408443B (en)
AU (1) AU2503099A (en)
DE (1) DE59913361D1 (en)
WO (1) WO1999043712A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200510A (en) * 1987-06-16 1993-04-06 Zymogenetics, Inc. Method for purifying factor viii:c, von willebrand factor and complexes thereof
NZ237244A (en) * 1990-03-02 1992-10-28 Bio Technology General Corp Cloning and production of human von willebrand factor analogues and compositions thereof
FR2686899B1 (en) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IT1256622B (en) * 1992-12-04 1995-12-12 Sclavo Spa PROCESS FOR THE EXTRACTION OF THE FACTOR VIII-FACTOR VON WILLEBRAND (FVIII: C-FVW) FROM TOTAL HUMAN PLASMA.
AT403764B (en) * 1996-03-15 1998-05-25 Immuno Ag STABLE FACTOR VIII / VWF COMPLEX
AT403765B (en) * 1996-04-12 1998-05-25 Immuno Ag METHOD FOR PRODUCING A PREPARATION CONTAINING A HIGHLY CLEANED COMPLEX
AT405403B (en) * 1997-02-27 1999-08-25 Immuno Ag CLEANING OF WILLEBRAND FACTOR BY CATION EXCHANGER CHROMATOGRAPHY

Also Published As

Publication number Publication date
ATE324379T1 (en) 2006-05-15
WO1999043712A1 (en) 1999-09-02
EP1056779A1 (en) 2000-12-06
DE59913361D1 (en) 2006-06-01
AT408443B (en) 2001-11-26
EP1056779B1 (en) 2006-04-26
ATA86698A (en) 2001-04-15
JP2002504561A (en) 2002-02-12

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase