AU2361295A - N-carboxyalkyl derivatives as antidegenerative active agents - Google Patents

N-carboxyalkyl derivatives as antidegenerative active agents

Info

Publication number
AU2361295A
AU2361295A AU23612/95A AU2361295A AU2361295A AU 2361295 A AU2361295 A AU 2361295A AU 23612/95 A AU23612/95 A AU 23612/95A AU 2361295 A AU2361295 A AU 2361295A AU 2361295 A AU2361295 A AU 2361295A
Authority
AU
Australia
Prior art keywords
antidegenerative
active agents
carboxyalkyl derivatives
carboxyalkyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU23612/95A
Other languages
English (en)
Inventor
Philippe L. Durette
William K. Hagmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2361295A publication Critical patent/AU2361295A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU23612/95A 1994-04-28 1995-04-24 N-carboxyalkyl derivatives as antidegenerative active agents Abandoned AU2361295A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23502094A 1994-04-28 1994-04-28
US235020 1994-04-28
PCT/US1995/004964 WO1995029689A1 (fr) 1994-04-28 1995-04-24 Derives de n-carboxyalkyle utilises comme agents antidegeneratifs

Publications (1)

Publication Number Publication Date
AU2361295A true AU2361295A (en) 1995-11-29

Family

ID=22883736

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23612/95A Abandoned AU2361295A (en) 1994-04-28 1995-04-24 N-carboxyalkyl derivatives as antidegenerative active agents

Country Status (2)

Country Link
AU (1) AU2361295A (fr)
WO (1) WO1995029689A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601042D0 (en) * 1996-01-17 1996-03-20 Smithkline Beecham Plc Medical use
NZ334897A (en) * 1996-12-09 2001-02-23 Warner Lambert Co Medicaments for treating and preventing heart failure and ventricular dilatation
ATE517926T1 (de) 2003-04-04 2011-08-15 Yeda Res & Dev Antikörper zur hemmung der aktivität von mmp-2 und mmp-9
JP5513130B2 (ja) 2007-02-23 2014-06-04 イェダ リサーチ アンド デベロップメント カンパニー リミテッド 金属タンパク質の活性を阻害するために有用な抗体および該抗体を含有する医薬組成物
CA2676946A1 (fr) 2009-08-28 2011-02-28 Lucie Peduto Inhibiteurs de l'enzyme adam12 et leur utilisation contre la fibrose induite par l'inflammation
EP3410849B1 (fr) 2016-02-05 2023-07-05 Institut Pasteur Utilisation d'inhibiteurs d'adam12 comme adjuvants dans les traitement antitumoraux

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
US4568666A (en) * 1984-10-18 1986-02-04 G. D. Searle & Co. Carboxylalkyl peptide derivatives
US4771037A (en) * 1986-01-21 1988-09-13 Ici Americas Inc. N-carboxyalkyl compounds
US5270326A (en) * 1990-11-21 1993-12-14 University Of Florida Treatment for tissue ulceration
CA2102890A1 (fr) * 1991-05-28 1992-11-29 Soumya P. Sahoo Derives n-carboxyalkylpeptidyles substitues utilises comme agents antidegeneratifs

Also Published As

Publication number Publication date
WO1995029689A1 (fr) 1995-11-09

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