AU2337599A - Efflux pump inhibitors - Google Patents

Efflux pump inhibitors

Info

Publication number
AU2337599A
AU2337599A AU23375/99A AU2337599A AU2337599A AU 2337599 A AU2337599 A AU 2337599A AU 23375/99 A AU23375/99 A AU 23375/99A AU 2337599 A AU2337599 A AU 2337599A AU 2337599 A AU2337599 A AU 2337599A
Authority
AU
Australia
Prior art keywords
pump inhibitors
efflux pump
efflux
inhibitors
pump
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU23375/99A
Inventor
Suzanne Chamberland
May Lee
Ving J. Lee
Roger Leger
Thomas Renau
Miles She
Zhijia J Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Trine Pharmaceuticals Inc
Original Assignee
Microcide Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/012,363 external-priority patent/US6114310A/en
Priority claimed from US09/020,001 external-priority patent/US6245746B1/en
Priority claimed from US09/089,734 external-priority patent/US6204279B1/en
Application filed by Microcide Pharmaceuticals Inc filed Critical Microcide Pharmaceuticals Inc
Publication of AU2337599A publication Critical patent/AU2337599A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AU23375/99A 1998-01-23 1999-01-22 Efflux pump inhibitors Abandoned AU2337599A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US09012363 1998-01-23
US09/012,363 US6114310A (en) 1998-01-23 1998-01-23 Efflux pump inhibitors
US09020001 1998-02-04
US09/020,001 US6245746B1 (en) 1998-01-23 1998-02-04 Efflux pump inhibitors
US09/089,734 US6204279B1 (en) 1998-06-03 1998-06-03 Peptidomimetic efflux pump inhibitors
US09089734 1998-06-03
PCT/US1999/001422 WO1999037667A1 (en) 1998-01-23 1999-01-22 Efflux pump inhibitors

Publications (1)

Publication Number Publication Date
AU2337599A true AU2337599A (en) 1999-08-09

Family

ID=27359623

Family Applications (1)

Application Number Title Priority Date Filing Date
AU23375/99A Abandoned AU2337599A (en) 1998-01-23 1999-01-22 Efflux pump inhibitors

Country Status (2)

Country Link
AU (1) AU2337599A (en)
WO (1) WO1999037667A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6346391B1 (en) 1999-07-22 2002-02-12 Trustees Of Tufts College Methods of reducing microbial resistance to drugs
EP1227084B1 (en) * 1999-10-28 2005-12-14 Trine Pharmaceuticals, Inc. Drug discharge pump inhibitors
AU2001268512A1 (en) * 2000-06-16 2002-01-02 Hercules Incorporated Chemically-modified peptides, compositions, and methods of production and use
JPWO2002087589A1 (en) * 2001-04-26 2004-08-12 第一製薬株式会社 Drug efflux pump inhibitor
US7056917B2 (en) * 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
CA2478183C (en) * 2002-03-12 2010-02-16 Merck & Co. Inc. Substituted amides
EP1539157B1 (en) 2002-09-18 2013-08-21 Trustees Of The University Of Pennsylvania Rapamycin for use in inhibiting or preventing choroidal neovascularization
US7829543B2 (en) 2003-01-07 2010-11-09 Paratek Pharmaceuticals, Inc. Substituted polyamines as inhibitors of bacterial efflux pumps
US7994225B2 (en) 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
JP2008500965A (en) * 2004-03-17 2008-01-17 エムペックス・ファーマシューティカルズ・インコーポレーテッド Use and administration of bacterial efflux pump inhibitors
US7879795B2 (en) * 2004-05-21 2011-02-01 Mpex Pharmaceuticals, Inc. Enhancement of tigecycline potency using efflux pump inhibitors
AU2005245962A1 (en) 2004-05-21 2005-12-01 Mpex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors and methods of treating bacterial infections
KR101387456B1 (en) 2005-02-09 2014-04-21 산텐 세이야꾸 가부시키가이샤 Liquid formulations for treatment of diseases or conditions
EP2001438A2 (en) 2006-02-09 2008-12-17 Macusight, Inc. Stable formulations, and methods of their preparation and use
DK2001466T3 (en) 2006-03-23 2016-02-29 Santen Pharmaceutical Co Ltd LOW-DOSAGE RAPAMYCINE FOR TREATMENT OF VASCULAR PERMEABILITY-RELATED DISEASES
WO2008019292A2 (en) * 2006-08-04 2008-02-14 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US8178490B2 (en) 2007-05-11 2012-05-15 Rempex Pharmaceuticals, Inc. Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
EP2975031A4 (en) 2013-03-14 2017-04-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10053468B2 (en) 2013-07-03 2018-08-21 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2015002230A1 (en) 2013-07-03 2015-01-08 武田薬品工業株式会社 Amide compound
WO2019223718A1 (en) * 2018-05-22 2019-11-28 成都先导药物开发股份有限公司 Immunomodulator
WO2021027722A1 (en) * 2019-08-09 2021-02-18 成都先导药物开发股份有限公司 Immunomodulator

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5753446A (en) * 1980-09-16 1982-03-30 Torii Yakuhin Kk Peptide derivative
US4448715A (en) * 1981-11-02 1984-05-15 University Of Miami Tagged pyroglu-L-Phe-L-Arg derivatives, substrates and assays for kallikrein
FR2611205B1 (en) * 1987-02-20 1990-03-02 Serbio DIPEPTIDES, PROCESS FOR THE PREPARATION AND USE IN THE DETERMINATION OF PROTEASES
US4980343A (en) * 1988-10-27 1990-12-25 Bayer Aktiengesellschaft Aminooxodihydroisoindoloquinazoline carcinostatic agents
US6090785A (en) * 1992-10-15 2000-07-18 Merck & Co., Inc. Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
US6214345B1 (en) * 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5989832A (en) * 1995-04-21 1999-11-23 Microcide Pharmaceuticals, Inc. Method for screening for non-tetracycline efflux pump inhibitors
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
JP2000509376A (en) * 1996-04-22 2000-07-25 マサチューセッツ インスティテュート オブ テクノロジー Suppression of immune response through inhibition of cathepsin S

Also Published As

Publication number Publication date
WO1999037667A1 (en) 1999-07-29

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase