AU2300302A - Tiltable nut - Google Patents

Description

-1-

AUSTRALIA

PATENTS ACT 1990 COMPLETE SPECIFICATION FOR A STANDARD PATENT

ORIGINAL

Name of Applicant: Actual Inventors: Address for Service: Novo Nordisk A/S Lars Peter Klitmose and Henrik Andersen and Preben Broskov Nielsen and John Thrane Hansen BALDWIN SHELSTON WATERS MARGARET STREET SYDNEY NSW 2000 CCN: 3710000352 Invention Title: 'TILTABLE NUT' Details of Original Application No. 80111/98 dated 15 Jun 1998 The following statement is a full description of this invention, including the best method of performing it known to me/us:- File: 26467AUP01 TILTABLE

NUT

The invention relates to syringes for dosed injection of a medicine from an exchangeable cartridge of the kind having a piston which is forced into a tubular cartridge to press out a dose of medicine corresponding to the movement of the piston, the syringe having a housing comprising a cartridge holder and a dosing mechanism, by which a dose is set and subsequently injected by successively advancing a piston rod to press the piston into the cartridge, said dosing mechanism comprising a threaded spindle and a nut member. cooperating with the spindle so that by setting of a dose relative rotation of the spindle and the o 10 nut member will move the nut member along the spindle, the position of the nut member on *the spindle defining how far the piston rod is advanced during the injection. The spindle may be formed by the piston rod which may be provided with an outer thread.

When the cartridge is empty said piston rod projects into the cartridge in almost the total length thereof. To change the cartridge the piston rod must first be drawn out of the empty cartridge, and thereafter it must be brought back to its initial position in the dose setting part.

The -last operation is made possible by locks getting unlocked when the empty cartridge is removed from the syringe, where after the piston rod may be pushed or screwed back to its initial position.

The release of said locking may be obtained either by bringing the inner. thread of the nut 0 member out of engagement with the spindle or by allowing a free relative rotation of the nut member and the' spindle. When the locking is released the nut member, which have during the injections performed been moved to a position on the spindle corresponding to a fully advanced piston rod, may be moved along the spindle back to its position corresponding to a totally retracted piston rod.

By the free rotation of the nut member relative to the spindle the nut may be screwed back to its initial position corresponding to a fully retracted piston rod. However, the nut have to be rotated about 75 turns and this screwing may demand some handiness. This problem may be overcome by using threads with a high pitch and low friction which allows the spindle to rotate by itself when the nut is pressed in the ayial dirmctliorn of sai,4 epindle, Another solution is to use a nut member comprising at least two parts which may be pulled apart so that their threads are drawn out of engagement with the thread of the spindle when the nut is going to be returned to its initial position. However, this solution may cause problems when the parts are brought together again to engage the thread of the spindle as it may be difficult to obtain the correct synchronisation between the position of the nut member on the spindle and the scale indicating the dose set. Further, the engagement between the threads is dependent on tolerances which may cause wear which makes the settings inaccurate.

It is an object of the invention to provide a nut providing a good engagement with the spindle and -the thread of which may easily be brought out of engagement with the thread of the spindle without involving parts which must be moved in relation to each other.

o This is obtained by a syringe as described in. the opening of this application using a nut which has two intersecting bores forming an angle with each other and of which a first bore has an inner thread matching the outer thread of the spindle and a second bore is smooth and fits slidingly over the thread of the spindle, the nut member being mounted to the piston rod tiltable between a first and a second position so that in the first position the threaded bore is coaxial with the spindle during dose setting and injection and in the second position to which the nut is tilted when acted upon to withdraw the piston rod and move said nut member along the spindle the smooth bore is coaxial with the spindle.

20 During normal use of the injection device the nut is held with its first bore coaxial with the spindle with the threaded parts of this first bore engaging the outer thread of the spindle.

o'ooe This way the nut may be moved along the spindle when said spindle and the nut are rotated relative to each other. When it is requested to move the nut along the spindle without performing said relative rotation the nut is tilted on the spindle to bring it into a second angular position relative to the spindle in which angular position the second bore is coaxial with the spindle. In this angular position the nut may be displaced along the spindle with the smooth surface of the second bore sliding over the tops of the threads of the spindle. When the nut has been moved to a wanted position along the spindle, the nut is tilted back to its first angular position with the first bore coaxial with the spindle and the threaded parts of this first bore engaging the threads of the spindle.

"flowing de inventiuon is explained in fiurther detaiis with references to the drawing, wherein 3 Figure 1 schematically shows a threaded spindle connected to a piston rod through a tiltable nut with a threaded and a smooth .bore, the nut being in a first position with the thread of the bore engaging the thread of the spindle, and Figure 2 the spindle nut and piston rod in figure 1 only with the nut tilted to a second position so that the spindle runs through the smooth walled bore.

In figure 1 a reciprocable and rotateable spindle 1 is provided with an outer thread 2 passing through a nut member 3 which has at a first side a journal 4 in which a pivot pin 5 on a piston 10 rod 6 is joumaled. The nut member 3 has two intersecting bores, a first bore coaxial with the spindle 1 in figure 1 and a second bore indicated by dotted lines 12 and intersecting the first bore forming an acute angle with this first bore. The first bore has an. inner thread 7 which in figure 1 engages the outer thread.2 of the spindle 1.

g* The spindle 1 forms a dose setting member of an injection device in which doses are set by rotating the spindle 1 about its axis. As the nut member is not rotateable, rotation of the spindle 2 will screw this spindle through the nut member 3. A dose is set by screwing the spindle in the direction shown by an arrow 8 and the set dose is injected by moving the spindie 1 without rotating it in the opposite direction shown by an arrow 9. The injection moveo 20 ment of the spindle will due to the engagement of the threads 2 and 7 of the spindle and the nut member, respectively, be transmitted to the nut member 3 and through the journal 4 and the pivot pin 5 further to the piston rod 6 which is moved in the direction indicated by an arrow 10. By the injection movement of the spindle a force is exerted on the nut member 3 as indicated by an arrow 11 which force will try, to rotate the nut member 3 about the pivot pin in a direction which brings the threads of the spindle and the nut member in tighter engagement.

By successive dose settings and injections the piston rod 6 is moved to its extreme position in the direction indicated by the arrow 10, i. e. a piston upon which the piston rod 6 acts is moved all the way into a cartridge. By the successive dose settings the spindle 1 has been screwed by its full length through the nut member 3 in the direction indicated by the arrow 8.

To enable a changing of the cartridge the niston o 6 hs to be idrawn and the nut.

member has to be moved from one end of the spindle 1 to the other. To enable such a movement the engagement between the threads of the spindle and the nut member has to be released. This is done by tilting the nut member to a second position so that the smooth walled bore of the nut member becomes coaxial with said spindle as shown in figure 2.

In figure 2 the piston rod 6 is omitted. To withdraw the piston rod the nut member must be drawn to the left in the figure 2. A drawing force is transmitted to the nut member from a withdrawal element which may be manually operated or automatically operated when a lid is opened to obtain access to an ampoule compartment. The not shown withdrawal element act by a force indicated by an arrow 13 on a second side of the nut member diametrically opposite said first side. The force indicated by the arrow 13 will together with a force indicated by an arrow 14, originating from the resistance against withdrawal which the piston rod exerts on the nut member, exert a torque on the nut member in a plane defined by the intersecting axis of the bores. This torque will draw the nut member to a second position in which the smooth walled bore is coaxial with the spindle 1 and keep the nut member in this tilted position as long as the withdrawing force is applied. With this second rotational position of the nut member 3 this nut member may be moved along the spindle as the top of the thread 2 of the spindle slides along the smooth wall of the smooth walled bore of the nut member 3.

1 1 1 The thread of the nut member is drawn out of engagement with the thread 2 of the spindle 1 as the threaded bore now is positioned as indicated by the dotted lines 15. The nut member can be biased towards its first rotational position in which the threads of the spindle and the 20 nut element are in engagement.

00.0ee

Claims (4)

1. A syringe having a housing, including a cartridge holder and a dosing mechanism by which a dose is set and subsequently injected by successively advancing a piston rod to press a piston into the cartridge, said dosing mechanism comprising a threaded spindle and a nut member co-operating with the spindle so that by setting of a dose relative rotation of the spindle and the nut member wil move the nut member along the spindle, the position of the nut member on the spindle defining how far the piston rod is advanced during the injec- f ion,. characterised in that the nut has two intersecting bores forming an angle with each 10 other and of which a first bore has an inner thread matching the outer thread -of the spindle and a second bore is smooth and fits slidingly over the thread of the spindle the nut member being mounted to the piston rod tiltable between a first and a second position so that in the first position the threaded bore is coaxial with the spindle during dose setting and .injection. and in the second position to which the nut is tilted when acted upon .to withdraw the piston 15 rod and move said nut member along the spindle the smooth bore is coaxial with the spindle.

2. yringe according to claim 1, wherein the nut member at a first side is hinged to the piston rod so that exertion a force on the nut member in a direction by which the piston rod is pressed in a direction by which an injection is performed will tilt said nut member into its first position.

3. Syringe according to claim 2, wherein the a piston withdrawal member act on the nut member at a second side of said member diametrically opposite said first side so that the nut member is tilted to its second position when the a piston rod withdrawal force is ap- plied to said nut member.

4. A syringe substantially as herein described with reference to the accompanying Figures 1 and 2. A syringe according to any one of claims 1 to 3 substantially as herein described with reference to the accompanying Figures 1 and 2. DATED this 7th day of March 2002 Novo Nordisk A/S Attorney: JACINTA FLATTERY-O'BRIEN Registered Patent Attorney of The Institute of Patent and Trade Mark Attorneys of Australia of BALDWIN SHELSTON WATERS