AU2023218255A1 - Visual inspection systems for containers of liquid pharmaceutical products - Google Patents
Visual inspection systems for containers of liquid pharmaceutical products Download PDFInfo
- Publication number
- AU2023218255A1 AU2023218255A1 AU2023218255A AU2023218255A AU2023218255A1 AU 2023218255 A1 AU2023218255 A1 AU 2023218255A1 AU 2023218255 A AU2023218255 A AU 2023218255A AU 2023218255 A AU2023218255 A AU 2023218255A AU 2023218255 A1 AU2023218255 A1 AU 2023218255A1
- Authority
- AU
- Australia
- Prior art keywords
- container
- profile view
- distance
- imager
- optical axis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011179 visual inspection Methods 0.000 title claims abstract description 33
- 239000007788 liquid Substances 0.000 title claims description 33
- 239000000825 pharmaceutical preparation Substances 0.000 title description 10
- 229940127557 pharmaceutical product Drugs 0.000 title description 5
- 230000003287 optical effect Effects 0.000 claims abstract description 65
- 238000007689 inspection Methods 0.000 claims abstract description 56
- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 35
- 238000005286 illumination Methods 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 71
- 230000007547 defect Effects 0.000 claims description 60
- 239000002245 particle Substances 0.000 claims description 40
- 239000000835 fiber Substances 0.000 claims description 24
- 238000003384 imaging method Methods 0.000 claims description 8
- 230000007246 mechanism Effects 0.000 claims description 7
- 238000013528 artificial neural network Methods 0.000 description 34
- 238000001514 detection method Methods 0.000 description 19
- 239000012530 fluid Substances 0.000 description 19
- 230000015654 memory Effects 0.000 description 19
- 239000000047 product Substances 0.000 description 15
- 239000011521 glass Substances 0.000 description 12
- 238000012545 processing Methods 0.000 description 12
- 238000012549 training Methods 0.000 description 12
- 238000010801 machine learning Methods 0.000 description 10
- 238000013019 agitation Methods 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 208000034656 Contusions Diseases 0.000 description 8
- 239000004033 plastic Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 238000010200 validation analysis Methods 0.000 description 6
- 208000034526 bruise Diseases 0.000 description 5
- 229940126534 drug product Drugs 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000012263 liquid product Substances 0.000 description 4
- 230000005499 meniscus Effects 0.000 description 4
- 239000002923 metal particle Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000010287 polarization Effects 0.000 description 4
- 238000009987 spinning Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000012797 qualification Methods 0.000 description 3
- 230000004075 alteration Effects 0.000 description 2
- 239000005356 container glass Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000013135 deep learning Methods 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000007667 floating Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 239000004990 Smectic liquid crystal Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000003098 cholesteric effect Effects 0.000 description 1
- 238000013145 classification model Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 210000002858 crystal cell Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000013528 metallic particle Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/90—Investigating the presence of flaws or contamination in a container or its contents
- G01N21/9018—Dirt detection in containers
- G01N21/9027—Dirt detection in containers in containers after filling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8806—Specially adapted optical and illumination features
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8851—Scan or image signal processing specially adapted therefor, e.g. for scan signal adjustment, for detecting different kinds of defects, for compensating for structures, markings, edges
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/90—Investigating the presence of flaws or contamination in a container or its contents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/95—Investigating the presence of flaws or contamination characterised by the material or shape of the object to be examined
- G01N21/958—Inspecting transparent materials or objects, e.g. windscreens
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8806—Specially adapted optical and illumination features
- G01N2021/8848—Polarisation of light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8851—Scan or image signal processing specially adapted therefor, e.g. for scan signal adjustment, for detecting different kinds of defects, for compensating for structures, markings, edges
- G01N2021/8854—Grading and classifying of flaws
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8851—Scan or image signal processing specially adapted therefor, e.g. for scan signal adjustment, for detecting different kinds of defects, for compensating for structures, markings, edges
- G01N2021/8887—Scan or image signal processing specially adapted therefor, e.g. for scan signal adjustment, for detecting different kinds of defects, for compensating for structures, markings, edges based on image processing techniques
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Signal Processing (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263307931P | 2022-02-08 | 2022-02-08 | |
| US63/307,931 | 2022-02-08 | ||
| US202263316763P | 2022-03-04 | 2022-03-04 | |
| US63/316,763 | 2022-03-04 | ||
| PCT/US2023/012458 WO2023154256A1 (en) | 2022-02-08 | 2023-02-07 | Visual inspection systems for containers of liquid pharmaceutical products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2023218255A1 true AU2023218255A1 (en) | 2024-06-13 |
Family
ID=85505460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023218255A Pending AU2023218255A1 (en) | 2022-02-08 | 2023-02-07 | Visual inspection systems for containers of liquid pharmaceutical products |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250130176A1 (https=) |
| EP (1) | EP4476533A1 (https=) |
| JP (1) | JP2025505135A (https=) |
| KR (1) | KR20240144922A (https=) |
| AU (1) | AU2023218255A1 (https=) |
| CA (1) | CA3242069A1 (https=) |
| IL (1) | IL313478A (https=) |
| MX (1) | MX2024009789A (https=) |
| WO (1) | WO2023154256A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116935080B (zh) * | 2023-09-19 | 2024-01-05 | 深圳市瑞意博医疗设备有限公司 | 一种针剂药品识别方法、系统及存储柜 |
| FR3158559A1 (fr) * | 2024-01-23 | 2025-07-25 | Tiama | Système et procédé de détection de défaut de type glaçure dans un récipient en verre, utilisant des filtres polarisants |
| WO2026029850A1 (en) * | 2024-07-31 | 2026-02-05 | Deka Products Limited Partnership | Systems, methods, and apparatuses for producing and packaging medical fluids |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3351910B2 (ja) * | 1994-09-01 | 2002-12-03 | エーザイ株式会社 | バイアル瓶の検査方法と装置 |
| JP2002098650A (ja) * | 2000-09-26 | 2002-04-05 | Matsushita Electric Works Ltd | 透明体検出方法およびそのシステム |
| US6989857B2 (en) * | 2003-06-30 | 2006-01-24 | Emhart Glass S.A. | Container inspection machine |
| WO2006011803A2 (en) * | 2004-07-30 | 2006-02-02 | Eagle Vision Systems B.V. | Apparatus and method for checking of containers |
| US8014586B2 (en) * | 2007-05-24 | 2011-09-06 | Applied Vision Corporation | Apparatus and methods for container inspection |
| CN101936917A (zh) * | 2010-08-24 | 2011-01-05 | 湖南大学 | 透明瓶外观及液体内的可见异物在线视觉检测装置 |
| TWI582408B (zh) * | 2011-08-29 | 2017-05-11 | 安美基公司 | 用於非破壞性檢測－流體中未溶解粒子之方法及裝置 |
| JP6451980B2 (ja) * | 2014-11-21 | 2019-01-16 | 和歌山県 | 画像生成装置 |
| DE102016011010B4 (de) * | 2016-09-14 | 2021-03-25 | Heye International Gmbh | Verfahren und Vorrichtung zur optischen Prüfung von Hohlglasartikeln |
| DE102018004539B4 (de) * | 2018-06-08 | 2023-04-20 | Heye International Gmbh | Verfahren und Vorrichtung zur optischen Inspektion von Hohlglasartikeln |
| CA3117950A1 (en) * | 2018-12-19 | 2020-06-25 | Amgen Inc. | Apparatus for resolving imaging problems caused by the meniscus |
| WO2020247357A1 (en) * | 2019-06-03 | 2020-12-10 | Amgen Inc. | 3d particle imaging in pharmaceutical containers |
-
2023
- 2023-02-07 US US18/835,139 patent/US20250130176A1/en active Pending
- 2023-02-07 KR KR1020247025906A patent/KR20240144922A/ko active Pending
- 2023-02-07 MX MX2024009789A patent/MX2024009789A/es unknown
- 2023-02-07 AU AU2023218255A patent/AU2023218255A1/en active Pending
- 2023-02-07 EP EP23709520.3A patent/EP4476533A1/en active Pending
- 2023-02-07 WO PCT/US2023/012458 patent/WO2023154256A1/en not_active Ceased
- 2023-02-07 CA CA3242069A patent/CA3242069A1/en active Pending
- 2023-02-07 JP JP2024545155A patent/JP2025505135A/ja active Pending
- 2023-02-07 IL IL313478A patent/IL313478A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023154256A1 (en) | 2023-08-17 |
| CA3242069A1 (en) | 2023-08-17 |
| EP4476533A1 (en) | 2024-12-18 |
| KR20240144922A (ko) | 2024-10-04 |
| US20250130176A1 (en) | 2025-04-24 |
| IL313478A (en) | 2024-08-01 |
| MX2024009789A (es) | 2024-09-18 |
| JP2025505135A (ja) | 2025-02-21 |
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