AU2022399451A1 - Improved methods of preparing different mesoderm cell types - Google Patents

Improved methods of preparing different mesoderm cell types Download PDF

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Publication number
AU2022399451A1
AU2022399451A1 AU2022399451A AU2022399451A AU2022399451A1 AU 2022399451 A1 AU2022399451 A1 AU 2022399451A1 AU 2022399451 A AU2022399451 A AU 2022399451A AU 2022399451 A AU2022399451 A AU 2022399451A AU 2022399451 A1 AU2022399451 A1 AU 2022399451A1
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Prior art keywords
signaling pathway
cells
hours
pathway activator
contacted
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Pending
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AU2022399451A
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English (en)
Inventor
Lu Han
Keishi KISHIMOTO
Mitsuru Morimoto
Aaron M. Zorn
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RIKEN
Cincinnati Children's Hospital Medical Center
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RIKEN
Cincinnati Children's Hospital Medical Center
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Publication of AU2022399451A1 publication Critical patent/AU2022399451A1/en
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0679—Cells of the gastro-intestinal tract
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/23—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the gastro-intestinal tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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    • C12N2513/00—3D culture

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  • Zoology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
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  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2022399451A 2021-12-03 2022-12-01 Improved methods of preparing different mesoderm cell types Pending AU2022399451A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163264927P 2021-12-03 2021-12-03
US63/264,927 2021-12-03
PCT/US2022/051561 WO2023102133A1 (en) 2021-12-03 2022-12-01 Improved methods of preparing different mesoderm cell types

Publications (1)

Publication Number Publication Date
AU2022399451A1 true AU2022399451A1 (en) 2024-06-06

Family

ID=86612984

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022399451A Pending AU2022399451A1 (en) 2021-12-03 2022-12-01 Improved methods of preparing different mesoderm cell types

Country Status (6)

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US (1) US20260002121A1 (cg-RX-API-DMAC7.html)
EP (1) EP4440586A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024543223A (cg-RX-API-DMAC7.html)
AU (1) AU2022399451A1 (cg-RX-API-DMAC7.html)
CA (1) CA3240872A1 (cg-RX-API-DMAC7.html)
WO (1) WO2023102133A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
CN116875538B (zh) * 2023-06-25 2024-09-24 昆明理工大学 培养基及用其诱导分化胚外内胚层和胚外中胚层的方法
WO2025072803A1 (en) 2023-09-29 2025-04-03 Children's Hospital Medical Center Ntrk2 signaling-mediated alveolar capillary injury and repair
WO2026015589A1 (en) * 2024-07-09 2026-01-15 Children's Hospital Medical Center Pancreatic organoids and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016141084A1 (en) * 2015-03-03 2016-09-09 The Board Of Trustees Of The Leland Stanford Junior University Producing mesodermal cell types and methods of using the same
CA3150015A1 (en) * 2019-08-28 2021-03-04 Children's Hospital Medical Center Organoid mesoderm lineage diversification

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Publication number Publication date
JP2024543223A (ja) 2024-11-19
US20260002121A1 (en) 2026-01-01
WO2023102133A1 (en) 2023-06-08
EP4440586A4 (en) 2026-02-11
CA3240872A1 (en) 2023-06-08
EP4440586A1 (en) 2024-10-09

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