AU2022350509A1 - Methods of treating hair-loss disorders with tyk2 inhibitors - Google Patents
Methods of treating hair-loss disorders with tyk2 inhibitors Download PDFInfo
- Publication number
- AU2022350509A1 AU2022350509A1 AU2022350509A AU2022350509A AU2022350509A1 AU 2022350509 A1 AU2022350509 A1 AU 2022350509A1 AU 2022350509 A AU2022350509 A AU 2022350509A AU 2022350509 A AU2022350509 A AU 2022350509A AU 2022350509 A1 AU2022350509 A1 AU 2022350509A1
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- Prior art keywords
- formula
- hair
- tyk2
- treated
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940123371 Tyrosine kinase 2 inhibitor Drugs 0.000 title claims abstract description 57
- 238000000034 method Methods 0.000 title claims abstract description 49
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- BZZKEPGENYLQSC-FIBGUPNXSA-N 6-(cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide Chemical group C1(CC1)C(=O)NC1=CC(=C(N=N1)C(=O)NC([2H])([2H])[2H])NC1=C(C(=CC=C1)C1=NN(C=N1)C)OC BZZKEPGENYLQSC-FIBGUPNXSA-N 0.000 claims description 8
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163247672P | 2021-09-23 | 2021-09-23 | |
| US63/247,672 | 2021-09-23 | ||
| PCT/US2022/044346 WO2023049241A1 (en) | 2021-09-23 | 2022-09-22 | Methods of treating hair-loss disorders with tyk2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022350509A1 true AU2022350509A1 (en) | 2024-04-04 |
Family
ID=83899658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022350509A Pending AU2022350509A1 (en) | 2021-09-23 | 2022-09-22 | Methods of treating hair-loss disorders with tyk2 inhibitors |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20240390372A1 (https=) |
| EP (1) | EP4404930A1 (https=) |
| JP (1) | JP2024533700A (https=) |
| KR (1) | KR20240065283A (https=) |
| CN (2) | CN118251222A (https=) |
| AU (1) | AU2022350509A1 (https=) |
| CA (1) | CA3232812A1 (https=) |
| IL (1) | IL311624A (https=) |
| MX (1) | MX2024003510A (https=) |
| WO (1) | WO2023049241A1 (https=) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3495358T (lt) | 2012-11-08 | 2022-05-25 | Bristol-Myers Squibb Company | Amidais pakeisti heterocikliniai junginiai, naudingi kaip il-12, il-23 ir (arba) ifn alfa atsako moduliatoriai |
| TWI582077B (zh) * | 2013-11-07 | 2017-05-11 | 必治妥美雅史谷比公司 | 作爲ＩＬ－１２、ＩＬ－２３及／或ＩＦＮα反應調節劑之經烷基－醯胺取代之吡啶化合物 |
| TW202515876A (zh) * | 2017-03-08 | 2025-04-16 | 日商武田藥品工業股份有限公司 | Tyk2抑制劑及其用途 |
| JP7113023B2 (ja) * | 2017-03-30 | 2022-08-04 | ブリストル－マイヤーズ スクイブ カンパニー | ６－（シクロプロパンアミド）－４－（（２－メトキシ－３－（１－メチル－１ｈ－１，２，４－トリアゾール－３－イル）フェニル）アミノ）－ｎ－（メチル－ｄ３）ピリダジン－３－カルボキシアミドの製造方法 |
| KR102848769B1 (ko) | 2018-05-31 | 2025-08-20 | 브리스톨-마이어스 스큅 컴퍼니 | 6-(시클로프로판카르복스아미도)-4-((2-메톡시-3-(1-메틸-1h-1,2,4-트리아졸-3-일)페닐)아미노)-n-(메틸-d3) 피리다진-3-카르복스아미드의 결정질 형태 |
| US20230093099A1 (en) * | 2019-04-02 | 2023-03-23 | Cullgen (Shanghai), Inc. | Compounds and methods of treating cancers |
| US11357775B2 (en) * | 2019-04-30 | 2022-06-14 | Celgene Corporation | Combination therapies comprising apremilast and Tyk2 inhibitors |
| SG11202112043PA (en) * | 2019-04-30 | 2021-11-29 | Celgene Corp | Combination therapies comprising apremilast and tyk2 inhibitors |
| US12570637B2 (en) | 2019-06-12 | 2026-03-10 | Bristol-Myers Squibb Company | Crystalline salt forms 6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-n-(methyld3) pyridazine-3-carboxamide |
| JP7812785B2 (ja) | 2019-09-18 | 2026-02-10 | ブリストル－マイヤーズ スクイブ カンパニー | Ｔｙｋ２阻害薬の剤形 |
| AU2021205465A1 (en) * | 2020-01-06 | 2022-07-14 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| CN111704617B (zh) * | 2020-06-15 | 2022-08-23 | 嘉兴特科罗生物科技有限公司 | 一种小分子化合物 |
| CN112142675B (zh) * | 2020-10-09 | 2021-11-30 | 嘉兴特科罗生物科技有限公司 | 一种作为jak激酶抑制剂的小分子化合物及其用途 |
-
2022
- 2022-09-22 EP EP22792963.5A patent/EP4404930A1/en active Pending
- 2022-09-22 JP JP2024518606A patent/JP2024533700A/ja active Pending
- 2022-09-22 CN CN202280075809.3A patent/CN118251222A/zh active Pending
- 2022-09-22 KR KR1020247012854A patent/KR20240065283A/ko active Pending
- 2022-09-22 AU AU2022350509A patent/AU2022350509A1/en active Pending
- 2022-09-22 CN CN202411332236.5A patent/CN119345364A/zh active Pending
- 2022-09-22 CA CA3232812A patent/CA3232812A1/en active Pending
- 2022-09-22 MX MX2024003510A patent/MX2024003510A/es unknown
- 2022-09-22 US US18/694,424 patent/US20240390372A1/en active Pending
- 2022-09-22 WO PCT/US2022/044346 patent/WO2023049241A1/en not_active Ceased
- 2022-09-22 IL IL311624A patent/IL311624A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20240065283A (ko) | 2024-05-14 |
| CA3232812A1 (en) | 2023-03-30 |
| JP2024533700A (ja) | 2024-09-12 |
| IL311624A (en) | 2024-05-01 |
| EP4404930A1 (en) | 2024-07-31 |
| US20240390372A1 (en) | 2024-11-28 |
| MX2024003510A (es) | 2024-04-09 |
| WO2023049241A1 (en) | 2023-03-30 |
| CN118251222A (zh) | 2024-06-25 |
| CN119345364A (zh) | 2025-01-24 |
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| Gerde et al. | POS0118 ADDING HYDROXYCHLOROQUINE IN REFRACTORY OBSTETRIC APS: OBSTETRIC OUTCOMES IN 182 PREGNANCIES | |
| Strasser et al. | OP0293 PHARMACODYNAMIC EFFECTS OF THE SELECTIVE S1P1 RECEPTOR MODULATOR CENERIMOD ON THE BLOOD TRANSCRIPTOME OF PATIENTS WITH SLE |