AU2022342266B2 - Combination drug therapies - Google Patents

Combination drug therapies

Info

Publication number
AU2022342266B2
AU2022342266B2 AU2022342266A AU2022342266A AU2022342266B2 AU 2022342266 B2 AU2022342266 B2 AU 2022342266B2 AU 2022342266 A AU2022342266 A AU 2022342266A AU 2022342266 A AU2022342266 A AU 2022342266A AU 2022342266 B2 AU2022342266 B2 AU 2022342266B2
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AU
Australia
Prior art keywords
substituted
disorder
alkyl
deuterium
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2022342266A
Other languages
English (en)
Other versions
AU2022342266A1 (en
Inventor
Brett J. GREENE
Robert MINO
Alex Nivorozhkin
Michael Palfreyman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cybin IRL Ltd
Original Assignee
Cybin IRL Ltd
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Filing date
Publication date
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Publication of AU2022342266A1 publication Critical patent/AU2022342266A1/en
Application granted granted Critical
Publication of AU2022342266B2 publication Critical patent/AU2022342266B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

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    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/13ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered from dispensers
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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Psychology (AREA)
  • Acoustics & Sound (AREA)
  • Primary Health Care (AREA)
  • Physics & Mathematics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AU2022342266A 2021-09-08 2022-03-31 Combination drug therapies Active AU2022342266B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163241891P 2021-09-08 2021-09-08
US63/241,891 2021-09-08
PCT/EP2022/058574 WO2023036473A1 (en) 2021-09-08 2022-03-31 Combination drug therapies

Publications (2)

Publication Number Publication Date
AU2022342266A1 AU2022342266A1 (en) 2024-02-01
AU2022342266B2 true AU2022342266B2 (en) 2026-03-26

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Country Link
US (1) US20240366655A1 (https=)
EP (1) EP4398871A1 (https=)
JP (1) JP2024533291A (https=)
KR (1) KR20240052775A (https=)
AU (1) AU2022342266B2 (https=)
CA (1) CA3231021A1 (https=)
WO (1) WO2023036473A1 (https=)

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Publication number Priority date Publication date Assignee Title
AU2021268204A1 (en) 2020-05-08 2022-12-08 Psilera Inc. Novel compositions of matter and pharmaceutical compositions
KR20240096817A (ko) 2020-05-19 2024-06-26 사이빈 아이알엘 리미티드 중수소화된 트립타민 유도체 및 사용 방법
US12122741B2 (en) 2020-08-18 2024-10-22 Cybin Irl Limited Therapeutic phenethylamine compositions and methods of use
IL308816A (en) 2021-05-25 2024-01-01 Atai Therapeutics Inc New n,n-dimethyltryptamine salts and crystalline salt forms
MX2023014620A (es) 2021-06-09 2024-01-30 Atai Therapeutics Inc Nuevos profarmacos y conjugados de dimetiltriptamina.
JP2024545787A (ja) 2021-12-30 2024-12-11 アタイ セラピューティクス, インコーポレイテッド 一酸化窒素送達剤としてのジメチルトリプタミン類似体
GB202214721D0 (en) * 2022-10-06 2022-11-23 Rewire Therapeutics Ltd A treatment for mental disorders
EP4704826A1 (en) * 2023-04-28 2026-03-11 Yale University Compositions and methods for treating post-traumatic stress disorder
US12303503B1 (en) 2023-11-16 2025-05-20 Biobina Llc Use of dextromethorphan in combination with CYP2D6 and CYP3A4 enzyme inhibitors for the treatment of pain
WO2025123137A1 (en) * 2023-12-15 2025-06-19 10763942 Canada Inc. (Dba. Purminds Neuropharma) Heterocyclic compounds and methods of preparation thereof
WO2025170990A1 (en) * 2024-02-06 2025-08-14 Atai Therapeutics, Inc. Controlled transmucosal release of dmt in combination with a monoamine oxidase inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020181194A1 (en) * 2019-03-07 2020-09-10 University Of Padova Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations
WO2020212951A1 (en) * 2019-04-17 2020-10-22 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612059A (en) 1988-08-30 1997-03-18 Pfizer Inc. Use of asymmetric membranes in delivery devices
US5798119A (en) 1995-06-13 1998-08-25 S. C. Johnson & Son, Inc. Osmotic-delivery devices having vapor-permeable coatings
US7267121B2 (en) 2004-04-20 2007-09-11 Aerogen, Inc. Aerosol delivery apparatus and method for pressure-assisted breathing systems
WO2021003467A1 (en) * 2019-07-04 2021-01-07 Sw Holdings, Inc. Metered dosing compositions and methods of use of psychedelic compounds
RU199823U1 (ru) 2020-06-10 2020-09-21 Общество С Ограниченной Ответственностью "Центр Передовых Радиационных Медицинских И Биологических Технологий Устройство для лечения бронхолегочных заболеваний

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020181194A1 (en) * 2019-03-07 2020-09-10 University Of Padova Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations
WO2020212951A1 (en) * 2019-04-17 2020-10-22 Compass Pathfinder Limited Methods for treating anxiety disorders, headache disorders, and eating disorders with psilocybin

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
5-MeO-DiPT & Nitrous Oxide - Erowid Exp - 'Traveling thru Headspace and Time', Available from the Internet: https://www.erowid.org/experiences/exp.php?ID=22618, Published 18 June 2006 according to EROWID, Last Retrieved 8th September 2025 *
5-MeO-DMT & Nitrous Oxide - Erowid Exp - 'Touch-Controlled Universes in Total Darkness', Available from the Internet: https://www.erowid.org/experiences/exp.php?ID=42203, Published 06 October 2005 according to EROWID *
Baker et al, Biochemical Pharmacology, Volume 31, Issue 15, 1 August 1982, Pages 2513-2516 *
Beaton et al, 'A comparison of the behavioral effects of proteo- and deutero-N, N-dimethyltryptamine', Pharmacology Biochemistry and Behavior, Volume 16, Issue 5, May 1982, Pages 811-814 *
DMT & Nitrous Oxide - Erowid Exp - 'An Outrageous Combination', Available from the Internet: https://www.erowid.org/experiences/exp.php?ID=66034, Published 28 September 2007 according to EROWID, Last Retrieved 8th September 2025 *
DMT & Nitrous Oxide - Erowid Exp - 'Visting Friends in Another Universe', Available from the Internet: https://www.erowid.org/experiences/exp.php?ID=74289, Published 18 June 2006 according to EROWID, Last Retrieved 8th September 2025 *
DPT & Ketamine - Erowid Exp - 'The Event-Informational Singularity,' Available from the Internet: https://www.erowid.org/experiences/exp.php?ID=100230, Published 21 May 2013 according to EROWID, Last Retrieved 8th September 2025 *
Hesselgren et al, 'Synthesis of six specifically deuterted indoles of biological interest', Journal of Labelled Compounds and Radiopharmaceuticals (1980), Vol 17, No 3, Pages 411-419 *
Ketamine & 5-MeO-DMT - Erowid Exp - 'Choosing to Stay in My Body', Available from the Internet: https://www.erowid.org/experiences/exp.php?ID=110796, Published 29 September 2017 according to EROWID, Last Retrieved 8th September 2025 *
Tearavarich et al, 'Microwave-accelerated preparation and analytical characterization of 5-ethoxy-N,N-dialkyl-[α,α,β,β-H4]- and [α,α,β,β-D4]-tryptamines', Drug Testing and Analysis (2011), Vol 3, No 9, Pp 598-608 *

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