AU2022320541A1 - Antibody competition model using affinities of hidden variables - Google Patents

Antibody competition model using affinities of hidden variables Download PDF

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Publication number
AU2022320541A1
AU2022320541A1 AU2022320541A AU2022320541A AU2022320541A1 AU 2022320541 A1 AU2022320541 A1 AU 2022320541A1 AU 2022320541 A AU2022320541 A AU 2022320541A AU 2022320541 A AU2022320541 A AU 2022320541A AU 2022320541 A1 AU2022320541 A1 AU 2022320541A1
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AU
Australia
Prior art keywords
competition
antibodies
hidden
data
antibody
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2022320541A
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English (en)
Inventor
Valentine Julie Layla BERTRAND DE PUYRAIMOND
Thomas Roderick DOCKING
Alexander Sewall FORD
Tomas GOGORZA
Stefan Edward HANNIE
Christopher Thaddeus Hughes
Kevin Richard JEPSON
Lucas KRAFT
Jordan John YAP
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AbCellera Biologics Inc
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AbCellera Biologics Inc
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Publication date
Application filed by AbCellera Biologics Inc filed Critical AbCellera Biologics Inc
Publication of AU2022320541A1 publication Critical patent/AU2022320541A1/en
Pending legal-status Critical Current

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional [2D] or three-dimensional [3D] molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30—Drug targeting using structural data; Docking or binding prediction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30—Unsupervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Theoretical Computer Science (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Software Systems (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Artificial Intelligence (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
AU2022320541A 2021-07-08 2022-07-08 Antibody competition model using affinities of hidden variables Pending AU2022320541A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163219578P 2021-07-08 2021-07-08
US63/219,578 2021-07-08
PCT/US2022/036517 WO2023009293A2 (en) 2021-07-08 2022-07-08 Antibody competition model using hidden variable affinities

Publications (1)

Publication Number Publication Date
AU2022320541A1 true AU2022320541A1 (en) 2024-02-15

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ID=84785421

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2022320541A Pending AU2022320541A1 (en) 2021-07-08 2022-07-08 Antibody competition model using affinities of hidden variables

Country Status (11)

Country Link
US (1) US20250364074A1 (https=)
EP (1) EP4367676A2 (https=)
JP (1) JP2024526314A (https=)
KR (1) KR20240025697A (https=)
CN (1) CN117882137A (https=)
AU (1) AU2022320541A1 (https=)
CA (1) CA3225236A1 (https=)
GB (1) GB2623274A (https=)
IL (1) IL309983A (https=)
MX (1) MX2024000443A (https=)
WO (1) WO2023009293A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117334247B (zh) * 2023-10-12 2025-07-08 北京百度网讯科技有限公司 抗原抗体亲和力预测模型的训练方法和抗体筛选方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8706421B2 (en) * 2006-02-16 2014-04-22 Microsoft Corporation Shift-invariant predictions

Also Published As

Publication number Publication date
CA3225236A1 (en) 2023-02-02
WO2023009293A9 (en) 2023-04-06
US20250364074A1 (en) 2025-11-27
GB202401655D0 (en) 2024-03-20
MX2024000443A (es) 2024-03-13
GB2623274A (en) 2024-04-10
JP2024526314A (ja) 2024-07-17
IL309983A (en) 2024-03-01
KR20240025697A (ko) 2024-02-27
WO2023009293A2 (en) 2023-02-02
CN117882137A (zh) 2024-04-12
WO2023009293A3 (en) 2023-05-19
EP4367676A2 (en) 2024-05-15

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