AU2022300984A1 - Methods of treating decreased bone mineral density with kringle containing transmembrane protein 1 (kremen1) inhibitors - Google Patents

Methods of treating decreased bone mineral density with kringle containing transmembrane protein 1 (kremen1) inhibitors Download PDF

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Publication number
AU2022300984A1
AU2022300984A1 AU2022300984A AU2022300984A AU2022300984A1 AU 2022300984 A1 AU2022300984 A1 AU 2022300984A1 AU 2022300984 A AU2022300984 A AU 2022300984A AU 2022300984 A AU2022300984 A AU 2022300984A AU 2022300984 A1 AU2022300984 A1 AU 2022300984A1
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Prior art keywords
kremen1
nucleic acid
subject
variant
acid molecule
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Pending
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AU2022300984A
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Inventor
Aris BARAS
Jonas BOVIJN
Luca Andrea LOTTA
Olukayode SOSINA
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of AU2022300984A1 publication Critical patent/AU2022300984A1/en
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
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    • C12N2310/531Stem-loop; Hairpin
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
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  • Physics & Mathematics (AREA)
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  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2022300984A 2021-07-02 2022-06-30 Methods of treating decreased bone mineral density with kringle containing transmembrane protein 1 (kremen1) inhibitors Pending AU2022300984A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163218212P 2021-07-02 2021-07-02
US63/218,212 2021-07-02
PCT/US2022/035783 WO2023278741A1 (en) 2021-07-02 2022-06-30 Methods of treating decreased bone mineral density with kringle containing transmembrane protein 1 (kremen1) inhibitors

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AU2022300984A1 true AU2022300984A1 (en) 2024-01-04

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AU2022300984A Pending AU2022300984A1 (en) 2021-07-02 2022-06-30 Methods of treating decreased bone mineral density with kringle containing transmembrane protein 1 (kremen1) inhibitors

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US (1) US20230021584A1 (https=)
EP (1) EP4363585A1 (https=)
JP (1) JP2024524375A (https=)
KR (1) KR20240043752A (https=)
CN (1) CN117836412A (https=)
AU (1) AU2022300984A1 (https=)
CA (1) CA3222830A1 (https=)
IL (1) IL309385A (https=)
WO (1) WO2023278741A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118298911B (zh) * 2024-04-12 2024-11-22 中山大学孙逸仙纪念医院 一种多部位慢性疼痛潜在治疗靶点确定系统

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Publication number Publication date
KR20240043752A (ko) 2024-04-03
JP2024524375A (ja) 2024-07-05
US20230021584A1 (en) 2023-01-26
EP4363585A1 (en) 2024-05-08
CN117836412A (zh) 2024-04-05
WO2023278741A1 (en) 2023-01-05
IL309385A (en) 2024-02-01
CA3222830A1 (en) 2023-01-05

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