AU2021392809A1 - Methods of engineering immune cells for enhanced potency and persistence and uses of engineered cells in immunotherapy - Google Patents

Methods of engineering immune cells for enhanced potency and persistence and uses of engineered cells in immunotherapy Download PDF

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Publication number
AU2021392809A1
AU2021392809A1 AU2021392809A AU2021392809A AU2021392809A1 AU 2021392809 A1 AU2021392809 A1 AU 2021392809A1 AU 2021392809 A AU2021392809 A AU 2021392809A AU 2021392809 A AU2021392809 A AU 2021392809A AU 2021392809 A1 AU2021392809 A1 AU 2021392809A1
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cells
gene
immune cells
edited
population
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Ivan Chan
Chao GUO
Alexandra Leida Liana LAZETIC
Guangnan LI
James Barnaby Trager
Don-Hong Wang
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Nkarta Inc
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Nkarta Inc
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4225—Growth factors
    • A61K40/4229—Transforming growth factor [TGF]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
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    • A61K39/001111—Immunoglobulin superfamily
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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AU2021392809A 2020-12-03 2021-12-02 Methods of engineering immune cells for enhanced potency and persistence and uses of engineered cells in immunotherapy Pending AU2021392809A1 (en)

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Application Number Priority Date Filing Date Title
US202063121206P 2020-12-03 2020-12-03
US63/121,206 2020-12-03
US202163201159P 2021-04-15 2021-04-15
US63/201,159 2021-04-15
US202163236167P 2021-08-23 2021-08-23
US63/236,167 2021-08-23
US202163264234P 2021-11-17 2021-11-17
US202163264223P 2021-11-17 2021-11-17
US63/264,223 2021-11-17
US63/264,234 2021-11-17
PCT/US2021/072715 WO2022120370A2 (en) 2020-12-03 2021-12-02 Methods of engineering immune cells for enhanced potency and persistence and uses of engineered cells in immunotherapy

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BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
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