AU2021359068A1 - Caninized antibodies to canine interleukin-31 receptor alpha - Google Patents

Caninized antibodies to canine interleukin-31 receptor alpha Download PDF

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Publication number
AU2021359068A1
AU2021359068A1 AU2021359068A AU2021359068A AU2021359068A1 AU 2021359068 A1 AU2021359068 A1 AU 2021359068A1 AU 2021359068 A AU2021359068 A AU 2021359068A AU 2021359068 A AU2021359068 A AU 2021359068A AU 2021359068 A1 AU2021359068 A1 AU 2021359068A1
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AU
Australia
Prior art keywords
seq
amino acid
acid sequence
canine
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021359068A
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English (en)
Other versions
AU2021359068A8 (en
AU2021359068A9 (en
Inventor
Mohamad Morsey
Anasuya SAHA
Yuanzheng Zhang
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Intervet International BV
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Intervet International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet International BV filed Critical Intervet International BV
Publication of AU2021359068A1 publication Critical patent/AU2021359068A1/en
Publication of AU2021359068A8 publication Critical patent/AU2021359068A8/en
Publication of AU2021359068A9 publication Critical patent/AU2021359068A9/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2021359068A 2020-10-15 2021-10-14 Caninized antibodies to canine interleukin-31 receptor alpha Pending AU2021359068A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202063092296P 2020-10-15 2020-10-15
US202063092294P 2020-10-15 2020-10-15
US63/092,296 2020-10-15
US63/092,294 2020-10-15
US202063127184P 2020-12-18 2020-12-18
US63/127,184 2020-12-18
US202163235257P 2021-08-20 2021-08-20
US202163235258P 2021-08-20 2021-08-20
US63/235,257 2021-08-20
US63/235,258 2021-08-20
PCT/EP2021/078386 WO2022079139A1 (en) 2020-10-15 2021-10-14 Caninized antibodies to canine interleukin-31 receptor alpha

Publications (3)

Publication Number Publication Date
AU2021359068A1 true AU2021359068A1 (en) 2023-06-15
AU2021359068A8 AU2021359068A8 (en) 2023-06-22
AU2021359068A9 AU2021359068A9 (en) 2024-06-06

Family

ID=78302732

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2021359068A Pending AU2021359068A1 (en) 2020-10-15 2021-10-14 Caninized antibodies to canine interleukin-31 receptor alpha
AU2021360208A Pending AU2021360208A1 (en) 2020-10-15 2021-10-14 Caninized rat antibodies to canine interleukin-31 receptor alpha

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021360208A Pending AU2021360208A1 (en) 2020-10-15 2021-10-14 Caninized rat antibodies to canine interleukin-31 receptor alpha

Country Status (8)

Country Link
US (2) US20240002518A1 (https=)
EP (2) EP4229084A1 (https=)
JP (2) JP2023545182A (https=)
CN (1) CN116348488A (https=)
AU (2) AU2021359068A1 (https=)
CA (2) CA3194384A1 (https=)
MX (2) MX2023004439A (https=)
WO (2) WO2022079139A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202112491WA (en) * 2019-07-31 2021-12-30 Hoffmann La Roche Antibodies binding to gprc5d
AU2021359068A1 (en) * 2020-10-15 2023-06-15 Intervet International B.V. Caninized antibodies to canine interleukin-31 receptor alpha
EP4642795A2 (en) 2022-12-27 2025-11-05 Invetx, Inc. Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use
AU2024210302A1 (en) 2023-01-20 2025-09-04 Invetx, Inc. Bispecific binding agents for use in companion animals
CN120865402A (zh) * 2023-11-27 2025-10-31 宁波贝安生物科技有限公司 抗il-31的抗体及其用途
WO2026032397A1 (en) * 2024-08-09 2026-02-12 Zai Lab (Shanghai) Co., Ltd. Binding molecules with an interleukin-31 receptor subunit alpha-antigen-binding domain and uses thereof

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AU584417B2 (en) 1985-04-01 1989-05-25 Lonza Group Ag Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
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ES2443022T3 (es) 2005-08-12 2014-02-17 Merck Frosst Canada Inc. Derivados de indol como antagonistas del receptor CRTH2
JP4884570B2 (ja) 2008-08-20 2012-02-29 ファイザー・インク ピロロ［２，３−ｄ］ピリミジン化合物
AU2009295229B2 (en) 2008-09-22 2014-02-27 Merck Canada Inc. Indole derivatives as CRTH2 receptor antagonists
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AU2016239858B2 (en) 2015-04-02 2021-07-01 Intervet International B.V. Antibodies to canine interleukin-4 receptor alpha
US11091556B2 (en) * 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
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Also Published As

Publication number Publication date
CN116348488A (zh) 2023-06-27
MX2023004439A (es) 2023-05-08
EP4229083A1 (en) 2023-08-23
CA3194384A1 (en) 2022-04-21
AU2021359068A8 (en) 2023-06-22
US12577310B2 (en) 2026-03-17
MX2023004438A (es) 2023-05-08
AU2021360208A1 (en) 2023-04-27
JP2023545183A (ja) 2023-10-26
AU2021360208A9 (en) 2025-03-27
JP2023545182A (ja) 2023-10-26
WO2022079139A1 (en) 2022-04-21
WO2022079138A1 (en) 2022-04-21
US20240002518A1 (en) 2024-01-04
CA3194457A1 (en) 2022-04-21
US20230391879A1 (en) 2023-12-07
AU2021359068A9 (en) 2024-06-06
EP4229084A1 (en) 2023-08-23

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Free format text: IN VOL 57 , NO 23 , PAGE(S) 3274 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME INTERVET INTERNATIONAL B.V., APPLICATION NO. 2021359068, UNDER INID (54) CORRECT THE TITLE TO READ CANINIZED ANTIBODIES TO CANINE INTERLEUKIN-31 RECEPTOR ALPHA

SREP Specification republished