AU2021322891A1 - Oligonucleotide treatment of hepatitis B patients - Google Patents

Oligonucleotide treatment of hepatitis B patients Download PDF

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Publication number
AU2021322891A1
AU2021322891A1 AU2021322891A AU2021322891A AU2021322891A1 AU 2021322891 A1 AU2021322891 A1 AU 2021322891A1 AU 2021322891 A AU2021322891 A AU 2021322891A AU 2021322891 A AU2021322891 A AU 2021322891A AU 2021322891 A1 AU2021322891 A1 AU 2021322891A1
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AU
Australia
Prior art keywords
oligonucleotide
seq
sequence
positions
nucleotides
Prior art date
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Pending
Application number
AU2021322891A
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English (en)
Inventor
Hardean ACHNECK
Bob Dale Brown
Douglas M. FAMBROUGH
Henrik Mueller
Søren OTTOSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Dicerna Pharmaceuticals Inc
Original Assignee
F Hoffmann La Roche AG
Dicerna Pharmaceuticals Inc
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Publication date
Application filed by F Hoffmann La Roche AG, Dicerna Pharmaceuticals Inc filed Critical F Hoffmann La Roche AG
Publication of AU2021322891A1 publication Critical patent/AU2021322891A1/en
Pending legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Saccharide Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2021322891A 2020-08-05 2021-08-05 Oligonucleotide treatment of hepatitis B patients Pending AU2021322891A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063061384P 2020-08-05 2020-08-05
US63/061,384 2020-08-05
PCT/EP2021/071824 WO2022029209A1 (en) 2020-08-05 2021-08-05 Oligonucleotide treatment of hepatitis b patients

Publications (1)

Publication Number Publication Date
AU2021322891A1 true AU2021322891A1 (en) 2023-03-09

Family

ID=77595500

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021322891A Pending AU2021322891A1 (en) 2020-08-05 2021-08-05 Oligonucleotide treatment of hepatitis B patients

Country Status (11)

Country Link
US (1) US20230357773A1 (https=)
EP (1) EP4192955A1 (https=)
JP (1) JP2023536999A (https=)
KR (1) KR20230043877A (https=)
CN (1) CN116194120A (https=)
AU (1) AU2021322891A1 (https=)
CA (1) CA3190794A1 (https=)
IL (1) IL300340A (https=)
MX (1) MX2023001443A (https=)
TW (1) TW202221122A (https=)
WO (1) WO2022029209A1 (https=)

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UA128786C2 (uk) 2017-10-20 2024-10-23 Дайсерна Фармасьютикалз, Інк Олігонуклеотид для лікування інфекції гепатиту в
CN112534055A (zh) 2018-07-13 2021-03-19 豪夫迈·罗氏有限公司 用于调节rtel1表达的寡核苷酸
KR20240101580A9 (ko) * 2021-11-11 2025-12-10 에프. 호프만-라 로슈 아게 Hbv 치료를 위한 약학 조합물
AU2024313135A1 (en) * 2023-06-23 2026-01-22 Brii Biosciences, Inc. Assessment and treatment of chronic hepatitis b
WO2025006149A2 (en) * 2023-06-27 2025-01-02 HBVtech LLC Methods for reducing hepatitis b virus surface antigen (hbsag) and the hepatitis b drugs used in the methods thereof
WO2025199466A1 (en) 2024-03-22 2025-09-25 Purdue Research Foundation Liver-specific asialoglycoprotein receptor targeting ligands, conjugates comprising same, and related compositions and methods of use
KR20260008676A (ko) * 2024-07-08 2026-01-16 항저우 티엔롱 파마슈티칼 컴퍼니 리미티드 HBV 유전자 발현을 표적하고 조절하기 위한 이중 가닥 RNAi 제제 및 그 응용

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KR101728655B1 (ko) 2008-12-18 2017-04-19 다이서나 파마수이티컬, 인크. 유전자 발현의 특이적 억제를 위한 연장된 다이서 기질 제제 및 방법
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CA2979490C (en) 2015-03-16 2023-07-18 F. Hoffmann-La Roche Ag Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
RU2747822C2 (ru) * 2016-03-14 2021-05-14 Ф. Хоффманн-Ля Рош Аг Олигонуклеотиды для понижения экспрессии pd-l1
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UA128786C2 (uk) * 2017-10-20 2024-10-23 Дайсерна Фармасьютикалз, Інк Олігонуклеотид для лікування інфекції гепатиту в

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Publication number Publication date
CN116194120A (zh) 2023-05-30
CA3190794A1 (en) 2022-02-10
EP4192955A1 (en) 2023-06-14
JP2023536999A (ja) 2023-08-30
TW202221122A (zh) 2022-06-01
KR20230043877A (ko) 2023-03-31
US20230357773A1 (en) 2023-11-09
IL300340A (en) 2023-04-01
WO2022029209A1 (en) 2022-02-10
MX2023001443A (es) 2023-04-14

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