AU2021251459A1 - Cell - Google Patents

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Publication number
AU2021251459A1
AU2021251459A1 AU2021251459A AU2021251459A AU2021251459A1 AU 2021251459 A1 AU2021251459 A1 AU 2021251459A1 AU 2021251459 A AU2021251459 A AU 2021251459A AU 2021251459 A AU2021251459 A AU 2021251459A AU 2021251459 A1 AU2021251459 A1 AU 2021251459A1
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Australia
Prior art keywords
domain
cell
cells
immune cell
seq
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AU2021251459A
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English (en)
Inventor
Vania BALDAN
Shaun CORDOBA
Alex Nicholson
Martin PULÉ
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Autolus Ltd
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Autolus Ltd
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    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Rheumatology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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AU2021251459A 2020-04-08 2021-04-08 Cell Pending AU2021251459A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2005216.3 2020-04-08
GBGB2005216.3A GB202005216D0 (en) 2020-04-08 2020-04-08 Cell
PCT/GB2021/050862 WO2021205172A1 (en) 2020-04-08 2021-04-08 Cell

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AU2021251459A1 true AU2021251459A1 (en) 2022-08-25

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US (2) US20230148144A1 (https=)
EP (2) EP4132567A1 (https=)
JP (3) JP2023520205A (https=)
CN (1) CN115348869A (https=)
AU (1) AU2021251459A1 (https=)
CA (1) CA3174659A1 (https=)
GB (1) GB202005216D0 (https=)
WO (2) WO2021205173A1 (https=)

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CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
IL308258A (en) 2021-05-05 2024-01-01 Immatics Biotechnologies Gmbh Bma031 antigen binding polypeptides
CN117511882A (zh) * 2022-08-03 2024-02-06 浙江大学医学院附属第一医院 一种通用型免疫效应细胞及其制备方法和应用
CN115747166B (zh) * 2022-10-13 2024-12-06 上海怡豪生物科技有限公司 一种通用型car-t细胞及其制备方法与应用
EP4608856A1 (en) * 2022-10-27 2025-09-03 CARGO Therapeutics, Inc. Compositions and methods for improved immunotherapies
CN121586777A (zh) * 2023-07-26 2026-02-27 上海邦耀生物医药有限公司 用于治疗疾病的方法和组合物

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US7381803B1 (en) 1992-03-27 2008-06-03 Pdl Biopharma, Inc. Humanized antibodies against CD3
WO2000063374A1 (en) 1999-04-16 2000-10-26 Celltech Therapeutics Limited Synthetic transmembrane components
CA2538141A1 (en) 2003-09-09 2005-03-17 Gpc Biotech Ag Therapeutic human anti-mhc class ii antibodies and their uses
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