AU2021228737A1 - Identifying methylation patterns that discriminate or indicate a cancer condition - Google Patents

Identifying methylation patterns that discriminate or indicate a cancer condition Download PDF

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Publication number
AU2021228737A1
AU2021228737A1 AU2021228737A AU2021228737A AU2021228737A1 AU 2021228737 A1 AU2021228737 A1 AU 2021228737A1 AU 2021228737 A AU2021228737 A AU 2021228737A AU 2021228737 A AU2021228737 A AU 2021228737A AU 2021228737 A1 AU2021228737 A1 AU 2021228737A1
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AU
Australia
Prior art keywords
cancer
methylation
fragment
state
fragments
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
AU2021228737A
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English (en)
Inventor
Earl Hubbell
Collin MELTON
Oliver Claude VENN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grail LLC
Original Assignee
Grail LLC
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Publication date
Application filed by Grail LLC filed Critical Grail LLC
Publication of AU2021228737A1 publication Critical patent/AU2021228737A1/en
Pending legal-status Critical Current

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    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • G06F18/20Analysing
    • G06F18/24Classification techniques
    • G06F18/241Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2415Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on parametric or probabilistic models, e.g. based on likelihood ratio or false acceptance rate versus a false rejection rate
    • G06F18/24155Bayesian classification
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
AU2021228737A 2020-02-28 2021-02-26 Identifying methylation patterns that discriminate or indicate a cancer condition Pending AU2021228737A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062983443P 2020-02-28 2020-02-28
US62/983,443 2020-02-28
PCT/US2021/020012 WO2021174072A1 (fr) 2020-02-28 2021-02-26 Identification de motifs de méthylation qui distinguent ou indiquent un état cancéreux

Publications (1)

Publication Number Publication Date
AU2021228737A1 true AU2021228737A1 (en) 2022-09-22

Family

ID=75223401

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021228737A Pending AU2021228737A1 (en) 2020-02-28 2021-02-26 Identifying methylation patterns that discriminate or indicate a cancer condition

Country Status (7)

Country Link
US (1) US20210292845A1 (fr)
EP (1) EP4111457A1 (fr)
JP (1) JP2023514851A (fr)
CN (1) CN115443507A (fr)
AU (1) AU2021228737A1 (fr)
CA (1) CA3169488A1 (fr)
WO (1) WO2021174072A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240003888A1 (en) 2022-05-17 2024-01-04 Guardant Health, Inc. Methods for identifying druggable targets and treating cancer
WO2024007205A1 (fr) * 2022-07-06 2024-01-11 何肇基 Procédé et système d'établissement d'un indicateur pour évaluer le degré de malignité d'un microenvironnement tissulaire, et procédé et système d'utilisation d'un indicateur pour évaluer le degré de malignité d'un microenvironnement tissulaire

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ706269A (en) * 2012-09-20 2016-08-26 Univ Hong Kong Chinese Non-invasive determination of methylome of fetus or tumor from plasma
WO2018027176A1 (fr) * 2016-08-05 2018-02-08 The Broad Institute, Inc. Procédés pour la caractérisation génomique
EP3535415A4 (fr) 2016-10-24 2020-07-01 The Chinese University of Hong Kong Méthodes et systèmes de détection d'une tumeur
CA3092998A1 (fr) 2018-03-13 2019-09-19 Grail, Inc. Detection et classification de fragments presentant des anomalies
WO2019178289A1 (fr) 2018-03-13 2019-09-19 Grail, Inc. Procédé et système de sélection, de gestion et d'analyse de données de dimensionnalité élevée
GB2587939B (en) 2018-04-02 2023-06-14 Grail Llc Methylation markers and targeted methylation probe panels
CN112218957A (zh) 2018-04-16 2021-01-12 格里尔公司 用于确定在无细胞核酸中的肿瘤分数的系统及方法
AU2019261597A1 (en) * 2018-04-24 2020-11-19 Grail, Llc Systems and methods for using pathogen nucleic acid load to determine whether a subject has a cancer condition
AU2019351130A1 (en) 2018-09-27 2021-04-08 Grail, Llc Methylation markers and targeted methylation probe panel
WO2020132148A1 (fr) 2018-12-18 2020-06-25 Grail, Inc. Systèmes et procédés d'estimation de fractions de source cellulaire à l'aide d'informations de méthylation
PT3914736T (pt) 2019-01-25 2024-03-27 Grail Inc Deteção de cancro, tecido do cancro de origem e/ou um tipo de celula de cancro
US20200340064A1 (en) 2019-04-16 2020-10-29 Grail, Inc. Systems and methods for tumor fraction estimation from small variants

Also Published As

Publication number Publication date
WO2021174072A1 (fr) 2021-09-02
CA3169488A1 (fr) 2021-09-02
CN115443507A (zh) 2022-12-06
EP4111457A1 (fr) 2023-01-04
US20210292845A1 (en) 2021-09-23
JP2023514851A (ja) 2023-04-11

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