AU2020102394A4

AU2020102394A4 - A system for iontophoresis power supply and data acquisition

Info

Publication number: AU2020102394A4
Application number: AU2020102394A
Authority: AU
Inventors: Mazahar Ahmed Nazeeruddin Farooqui; Abdul Jaleel Abdul Haque; Abdul Raoof Khan; Surekha Vishnupant Munde; Yusuf Hanif Shaikh; Kranti Ramdas Zakde
Original assignee: Farooqui Mazahar Ahmed Nazeeruddin Dr; Haque Abdul Jaleel Abdul Dr; Khan Abdul Raoof Dr; Munde Surekha Vishnupant Dr; Shaikh Yusuf Hanif Dr; Zakde Kranti Ramdas Dr
Current assignee: Farooqui Mazahar Ahmed Nazeeruddin Dr; Haque Abdul Jaleel Abdul Dr; Khan Abdul Raoof Dr; Munde Surekha Vishnupant Dr; Shaikh Yusuf Hanif Dr; Zakde Kranti Ramdas Dr
Priority date: 2020-09-23
Filing date: 2020-09-23
Publication date: 2020-11-05
Anticipated expiration: 2028-09-23

Abstract

The present invention relates to a system for iontophoresis power supply and data acquisition. The object is to provide system for drug transport across membrane under the influence of electric pulses. It has data acquisition system to read two analogue signals with full scale range of 0 to 5 V. Microcontroller based development board is used in which program is loaded to generate the voltage pulse by switching the relay at desired regular intervals. It can sense any of the two analogue inputs or both at regular intervals of time as set by user or at one minute and send the measured value as serial data to computer using USB port. The readings are displayed on computer screen in graphical form and data is saved in file. Following invention is described in detail with the help of Figure 1 of sheet 1 showing block diagram of the proposed system. 1/1 102 110 104 108 112 1 115 Figure I

Description

1/1

102 110

104 108 112 1 115

Figure I

A SYSTEM FOR IONTOPHORESIS POWER SUPPLY AND DATA ACQUISITION

Technical field of invention:

[001] Present invention in general relates to the field of physics and more specifically to a system for iontophoresis to transport drug across membrane under the influence of electric pulses.

Background of the invention:

[002] lontophoresis is a process of transdermal drug delivery by use of a voltage gradient on the skin. Molecules are transported across the stratum comeum by electrophoresis and electroosmosis and the electric field can also increase the permeability of the skin. These phenomena, directly and indirectly, constitute active transport of matter due to an applied electric current. The transport is measured in units of chemical flux, commonly pmol/ (cm 2 *hour). Iontophoresis has experimental, therapeutic and diagnostic applications.

'0 [003] Recently, iontophoresis has come into increasing attention as an effective method for topical application of ionic agents or drugs by promoting absorption through the skin. Iontophoresis techniques are disclosed in, for example, Glass, J. M. et al., Int. J. Dermatol. 19,519; Russo J., Am. J. Hosp. Pharm. 37,843; Gangarosa, L. P. et al., J. Pharmacol. Exp. Ther. 212,377; Kwon, B. S. et al., J. Infect. Dis 140,1014; Hill, J. M. et al., Ann. N.Y. Acad. Sci. 284,604 and Tannebaum, M. Phys. Ther. 60,792.

[004] The iontophoresis disclosed in these prior arts is usually carried out by connecting the output terminal of a continuous direct current generator or pulsed direct current generator to a first or active electrode composed of a metal plate or other conductive substances covered with a moistened pad of porous material impregnated with an aqueous solution of ionic drug and a second or indifferent electrode structured similar to the first electrode but not soaked with the drug.

[005] From the above, it is clear that actual application of iontophoresis is very troublesome. While iontophoresis is a very effective method for drug application, this troublesome application had limited its spread. Further, the first and second electrodes have usually been fixed to the affected area of the body by means of, for example, rubber band, and the electric current flows through the skin. This has made it easy for bums to occur due to poor contact between the skin and the electrodes. Thus, an ammeter must be continually monitored during the application. For these reasons, conventional iontophoresis cannot become popularized as a home curative means, although it can be used in hospitals and clinics.

[006] Although many inventors are developed for iontophoresis devices and methods and some of them are such as- US20150231386A1 discloses iontophoresis drug delivery system and method for denervation of the renal sympathetic nerve and iontophoretic drug delivery, US4764164A discloses iontophoresis device, EP0911060A2 discloses iontophoresis system with voltage step-up circuit, EP 1925334 Al discloses iontophoresis device and power supply device for iontophoresis device, US20070088332A1 discloses iontophoresis device, US8214030B2 discloses iontophoresis apparatus and method.

[007] Therefore there is need to provide an improved system and methods for iontophoresis. '0 Hence the present invention provides an iontophoresis power supply and data acquisition system. The present system is intended for delivering electric current pulses of desired duration of interest to iontophoresis study and related data acquisition that can prove to be useful for optimization of electric pulse duration for drug transport across the membrane.

Object of the invention:

[008] Primary object of the present invention is to provide an iontophoresis power supply and data acquisition system.

[009] Another object of the present invention is to provide drug transport using iontophoresis across membrane under the influence of electric pulses.

[0010] Other objects, features and advantages will become apparent from detail description and appended claims to those skilled in art.

Summary of the invention:

[0011] Accordingly following invention provides an iontophoresis power supply and data acquisition system. The proposed invention provides a system for drug transport across membrane using iontophoresis under the influence of electric pulses. The system uses a microcontroller in which program is stored to implement desired functionality of generation of voltage pulses of interest to iontophoresis. The invention functions under the control of a microcontroller which is a part of the microcontroller development board (MCU board 108). Electric power for this microcontroller development board is provided by power supply (102) and the power is consistent with the requirements of the microcontroller development board in terms of the voltage and current capabilities. Analogue input 1 (104) and Analogue input 2 (106) are the inputs of the measuring system to which analogue signal in the range of 0 - 5 V dc can be connected for the purpose of measurement. The data transfer with the computer is accomplished through USB port (110) which directly connects to an external computer on which a controlling program is running. The iontophoresis make use of electric pulses for drug transport across membranes and the pulses are generated by switching the relay in the '0 relay unit (114). The current provided by the relays can be adjusted using a variable resistance or potentiometer working as current control (114).

Brief description of drawing:

[0012] This invention is described by way of example with reference to the following drawing where,

[0013] Figure 1 of sheet 1 shows the block diagram for the proposed system. Where, 102 denotes power supply, 104 denotes analog input 1, 106 denotes analog input 2, 108 denotes MCU board,

110 denotes USB port, 112 denotes current control, 114 denotes relay unit, 115 denotes to cell electrodes.

[0014] In order that the manner in which the above-cited and other advantages and objects of the invention are obtained, a more particular description of the invention briefly described above will be referred, which are illustrated in the appended drawing. Understanding that these drawing depict only typical embodiment of the invention and therefore not to be considered limiting on its scope, the invention will be described with additional specificity and details through the use of the accompanying drawing.

Detailed description of the invention:

[0015] The present invention relates to an iontophoresis power supply and data acquisition system. The proposed invention provides a system for drug transport across membrane using iontophoresis under the influence of electric pulses.

[0016] The proposed invention provides pulsating voltage pulses of desired duration for use in to iontophoresis. It consists of a microcontroller development board in which a program is stored to implement desired functionality of generation of voltage pulses of interest to iontophoresis. The voltage pulses are generated by switching of a relay and the microcontroller based system is connected to a computer.

[0017] In the preferred embodiment the microcontroller development board Arduino nano which is using contains a microcontroller AT328P. This microcontroller has volatile and non volatile memory instructions that are to be present for long time even after removing power to the microcontroller are stored in non volatile memory and temporary information is saved in volatile memory that is available till the microcontroller is powered on and is lost on switching the power off.

[0018] It makes use of electromagnetic relays that are used for switching ON and OFF the iontophoresis power supply. This power is derived from a 12 V DC source attached to the device and the power is switched ON and OFF by the device via microcontroller based on the built in program which in turn is controlled by a computer program on a computer to which the iontophoresis power supply and data acquisition system is attached. The switching relays need driver circuitry to increase the strength of current from the microcontroller.

[0019] In the proposed system the time duration for which the power supply remains ON and the duration for which it remains OFF are set from the main control panel of the system. The amount of current coming from the system can be controlled using a dimple potentiometer. The present system makes measurements at preset intervals of time like few seconds or a minute. These measurements are done at the ADC of the microcontroller present in the Arduino nano and sent via serial communication to the computer where these measurements are displayed and stored. At the end of a series of measurements with 90 measurements the resulting information is saved in a computer file which can be used for further analysis and interpretation.

[0020] Accordingly, the invention functions under the control of a microcontroller which is a part of the microcontroller development board (MCU board 108). Electric power for this '0 microcontroller development board is provided by power supply (102) and the power is consistent with the requirements of the microcontroller development board in terms of the voltage and current capabilities. Analogue input 1 (104) and Analogue input 2 (106) are the inputs of the measuring system to which analogue signal in the range of 0 - 5 V dc can be connected for the purpose of measurement. The data transfer with the computer is accomplished through USB port (110) which directly connects to an external computer on which a controlling program is running. The iontophoresis make use of electric pulses for drug transport across membranes and the pulses are generated by switching the relay in the relay unit (114). The current provided by the relays can be adjusted using a variable resistance or potentiometer working as current control (114).

[0021] Yet in the embodiment data acquisition system is inbuilt that can take one reading every minute for desired interval of time say 90 minutes. This input can be any analytic instrument whose output is suitable modified to be compatible with the 0 - 5 V DC range of

ADC input. The computer side controlling program saves the data in a computer file having specified name and extension.

[0022] Additional advantages and modification will readily occur to those skilled in art. Therefore, the invention in its broader aspect is not limited to specific details and representative embodiments shown and described herein. Accordingly various modifications may be made without departing from the spirit or scope of the general invention concept as defined by the appended claims and their equivalents.

Editorial Note 2020102394 There is only two pages of the claim

Claims

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:

1. A system for iontophoresis power supply and data acquisition consists of a microcontroller development board in which a program is stored to implement desired functionality of generation of voltage pulses of interest to iontophoresis, characterized in that;

a microcontroller development board Arduino nano contains a microcontroller AT328P is implemented;

a switching relays provided with driver circuitry to increase the strength of current from the said microcontroller wherein electric power for this microcontroller development board is provided by power supply (102);

an analogue input 1 (104) and analogue input 2 (106) are configured to which analogue signal in the range of 0 - 5 V dc connected for the purpose of measurement.

a dimple potentiometer is embedded to control the amount of current coming from the system;

wherein the measurements are done at the ADC of the microcontroller present in the Arduino nano and sent via serial communication to the computer where these measurements are displayed and stored;

and the voltage pulses are generated by switching of a relay and the microcontroller based system is connected to a computer.

2. The system as claimed in claim 1 wherein; the power is switched ON and OFF by the device via microcontroller based on the built in program which in turn is controlled by a computer program on a computer to which the iontophoresis power supply and data acquisition system is attached.

3. The system as claimed in claim 1 wherein; the time duration for which the power supply remains ON and the duration for which it remains OFF are set from the main control panel of the system.

4. The system as claimed in claim 1 wherein; data transfer with the computer is accomplished through USB port (110) which directly connects to an external computer on which a controlling program is running.

5. The system as claimed in claim 1 wherein pulses are generated by switching the relay in the relay unit (114) and the current provided by the relays adjusted using a variable resistance or potentiometer working as current control (114).