AU2018206134A1 - IL-8 inihibitors for use in the treatment of some urological disorders - Google Patents

IL-8 inihibitors for use in the treatment of some urological disorders Download PDF

Info

Publication number
AU2018206134A1
AU2018206134A1 AU2018206134A AU2018206134A AU2018206134A1 AU 2018206134 A1 AU2018206134 A1 AU 2018206134A1 AU 2018206134 A AU2018206134 A AU 2018206134A AU 2018206134 A AU2018206134 A AU 2018206134A AU 2018206134 A1 AU2018206134 A1 AU 2018206134A1
Authority
AU
Australia
Prior art keywords
inhibitor
use according
pct
treatment
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2018206134A
Other languages
English (en)
Inventor
Marcello Allegretti
Andrea Aramini
Gianluca Bianchini
Laura Brandolini
Maria Candida Cesta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe Farmaceutici SpA
Original Assignee
Dompe Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe Farmaceutici SpA filed Critical Dompe Farmaceutici SpA
Publication of AU2018206134A1 publication Critical patent/AU2018206134A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/4211,3-Oxazoles, e.g. pemoline, trimethadione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41681,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2018206134A 2017-01-03 2018-01-02 IL-8 inihibitors for use in the treatment of some urological disorders Abandoned AU2018206134A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17150176.0 2017-01-03
EP17150176.0A EP3342407A1 (en) 2017-01-03 2017-01-03 Il-8 inihibitors for use in the treatment of some urological disorders
PCT/EP2018/050009 WO2018127469A1 (en) 2017-01-03 2018-01-02 Il-8 inihibitors for use in the treatment of some urological disorders

Publications (1)

Publication Number Publication Date
AU2018206134A1 true AU2018206134A1 (en) 2019-05-23

Family

ID=57758480

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2018206134A Abandoned AU2018206134A1 (en) 2017-01-03 2018-01-02 IL-8 inihibitors for use in the treatment of some urological disorders

Country Status (14)

Country Link
US (1) US20190336484A1 (https=)
EP (2) EP3342407A1 (https=)
JP (1) JP2020503267A (https=)
KR (1) KR20190102177A (https=)
CN (1) CN109937037A (https=)
AU (1) AU2018206134A1 (https=)
BR (1) BR112019009588A2 (https=)
CA (1) CA3046531A1 (https=)
EA (1) EA201991357A1 (https=)
IL (1) IL267577A (https=)
MA (1) MA47199A (https=)
MX (1) MX2019007972A (https=)
WO (1) WO2018127469A1 (https=)
ZA (1) ZA201902427B (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3868368A1 (en) * 2020-02-21 2021-08-25 Dompe' Farmaceutici S.P.A. Cxcl8 (interleukin-8) activity inhibitor and corticosteroid combination and pharmaceutical composition and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1212051A4 (en) * 1999-08-27 2004-03-31 Merck & Co Inc METHOD FOR TREATING OR PREVENTING CHEMICAL PROSTATITIS OR CHRONIC POOL PAIN
PL1776336T3 (pl) 2004-03-23 2010-06-30 Dompe Farm Spa Pochodne kwasu 2-fenylopropionowego i zawierające je kompozycje farmaceutyczne
EP2166006A1 (en) 2008-09-18 2010-03-24 Dompe' S.P.A. 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
WO2010078403A2 (en) 2008-12-30 2010-07-08 Lipella Pharmaceuticals Inc. Methods and compositions for diagnosing urological disorders
US20120076791A1 (en) * 2010-09-29 2012-03-29 Philip Bosch Methods Of Treating Chronic Prostatitis/Chronic Pelvic Pain Syndrome
CN105582134A (zh) * 2014-09-12 2016-05-18 青岛华之草医药科技有限公司 一种治疗前列腺炎的中药组合物
EP3117835A1 (en) * 2015-07-14 2017-01-18 Dompé farmaceutici s.p.a. Il-8 inhibitors for use in the treatment of certain urological disorders

Also Published As

Publication number Publication date
WO2018127469A1 (en) 2018-07-12
IL267577A (en) 2019-08-29
KR20190102177A (ko) 2019-09-03
MX2019007972A (es) 2019-09-09
EP3342407A1 (en) 2018-07-04
MA47199A (fr) 2019-11-13
JP2020503267A (ja) 2020-01-30
BR112019009588A2 (pt) 2019-08-06
EA201991357A1 (ru) 2019-12-30
CA3046531A1 (en) 2018-07-12
CN109937037A (zh) 2019-06-25
EP3565545A1 (en) 2019-11-13
US20190336484A1 (en) 2019-11-07
ZA201902427B (en) 2020-08-26

Similar Documents

Publication Publication Date Title
US20250032461A1 (en) Il-8 inihibitors for use in the treatment of some urological disorders
JP2004531514A (ja) 尿失禁の処置のための選択的cox−2阻害剤の使用
WO2014124523A1 (en) A method of treating obesity
US20190336484A1 (en) Il-8 inhibitors for use in the treatment of some urological disorders
Zhou et al. Fruit bromelain ameliorates rat constipation induced by loperamide
US20250041285A1 (en) Modifying the expression level of a gene encoding an cyclooxygenase enzyme by treating a human subject with a nitroxide
Sandberg Female Protection from Renal Disease Progression is Associated with 17Beta-Estradiol (E2)-Mediated Attenuation of the Injury-Induced Increase in NAD (P) H Oxidase Activity: P71
Ergul Increased ET-1-Mediated Vasoconstriction but not Impaired Vasorelaxation of Mesenteric Resistance Vessels in Type 2 Diabetic Gk Rats-Interaction of Endothelin Receptors: P51
Luft Various Inversions, Deletions, and Reinsertions on Chromosome 12p in Autosomal-Dominant Hypertension with Brachydactyly-A Fish-Study in Four Families and One Sporadic Case: P91
Oyekan Regulation of Blood Pressure, Natriuresis, and Renal Thiazide/Amiloride Sensitivity in PPARα-Null Mice: P93
Fagan Increased Cerebrovascular Tortuosity Index is Associated with Increased Hemorrhagic Transformation in Acute Ischemic Stroke: P56
Rotter Genetic Architecture of the Salt Sensitivity of Blood Pressure and Correlation with Insulin Resistance in Hypertensive Hispanic Families: P85
Haubitz Highly Increased Circulating Endothelial Cells in Women with Preeclampsia: P101
Frohlich High-Salt Diet Produces Severe Renal Dysfunction Independently of Changes in Arterial Pressure in Spontaneously Hypertensive Rats (SHR): P73
Bailey Role of VEGF in Renal Mechanisms of Hypertension: VEGF Receptor Inhibition Enhances Dietary Salt-Induced Hypertension in Sprague-Dawley (SD) Rats: P67
Wang Increased GFR and Renal Excretory Function by Activation of TRPV1 in the Isolated Perfused Kidney: P75
Dong Comprehensive Analyses of RAAS Polymorphisms on Blood Pressure at Rest and during Behavioral Stress in Normotensive Youth: P88
Soares-da-Silva Inadequate Regulation of Renal B0AT1 Gene Expression in the Spontaneous Hypertensive Rat: P82
Igarashi Reduced Capacity of Heme Oxygenese-1 Induction in Patients with Coronary Artery Disease: P92
O’Connor Targeted Ablation of the Chromogranin A Gene: Profound Alterations in Cardiovascular and Renal Physiology: P84
Pirola Association of the C-344T Aldosterone Synthase Gene Variant with Essential Hypertension and Related Phenotypes: A Meta-Analysis: P90
Nasjletti Environmental Carbon Monoxide is a Determinant of Oxidative Stress and Defective Relaxing Responsiveness to Acetylcholine: P50
Sun Heart-Specific Inhibition of Protooncogene C-myc Attenuates Cold-Induced Cardiac Hypertrophy: P94
Haubitz Interaction of Apoptotic and Healthy Microvascular Endothelial Cells: Implications on Inflammatory Responses: P49
Samani Angiotensinogen Gene Variants do not Affect Ambulatory Blood Pressure in the General Population: P97

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period