AU2018204614A1

AU2018204614A1 - Medical valve system

Info

Publication number: AU2018204614A1
Application number: AU2018204614A
Authority: AU
Inventors: Sebastian BIERI; Matthias Denk; Mayur Suresh DUDHANE; Frank EISEN; Fritz KOBEL; Fritz Zwygart
Original assignee: B Braun Melsungen AG
Current assignee: B Braun Melsungen AG
Priority date: 2017-06-27
Filing date: 2018-06-25
Publication date: 2019-01-17
Anticipated expiration: 2038-06-25
Also published as: EP3421076A1; RU2018122294A; RU2018122294A3; DE102017210794A1; EP3421076B1; AU2018204614B2; RU2765603C2; CN109125916A; CN109125916B

Abstract

Abstract 1. Medical valve system. 2.1 A medical valve system of the type in question, having - a valve housing with at least two medicament inlets which are fluidically connected in each case to a medicament outlet arranged on an inner circumferential surface of the housing, - a valve body which is arranged at least partially in the valve housing and which is rotatable about a rotation axis relative to the inner circumferential surface of the housing, with an outer circumferential surface of the body and an inner body surface and with a passageway arranged on the outer circumferential surface of the body, - a flushing inlet which is fluidically connected to a flushing outlet, and - a valve outlet which is fluidically connected to the passageway, - wherein the valve body is rotatable to - at least two medicament positions and - at least one flushing position, is known. 2.2 According to the invention, the flushing inlet and the valve outlet are arranged on the valve body. 2.3 Use in infusion therapy. 3. Fig. 1 El Fig. 1

Description

ORIGINAL COMPLETE SPECIFICATION

STANDARD PATENT

Invention Title

Medical valve system

The following statement is a full description of this invention, including the best method of performing it known to me/us:la

2018204614 25 Jun 2018 [0001] The invention relates to a medical valve system for administering at least two medicament liquids, having [0002] - a valve housing with at least two medicament inlets which each receive one of the medicament liquids and which are fluidically connected in each case to a medicament outlet arranged on an inner circumferential surface of the housing, [0003] - a valve body which is arranged at least partially in the valve housing and which is rotatable about a rotation axis relative to the inner circumferential surface of the housing, with an outer circumferential surface of the body and an inner body surface and with a passageway arranged on the outer circumferential surface of the body, [0004] - a flushing inlet which receives a flushing liquid and which is fluidically connected to a flushing outlet, and [0005] - a valve outlet which discharges the flushing liquid and/or at least one of the medicament liquids and which is fluidically connected to the passageway, [0006] - wherein the valve body is rotatable to [0007] - at least two medicament positions, in which the passageway is in each case fluidically connected to one of the medicament outlets in such a way that the respective medicament liquid can be conveyed through the valve outlet, and [0008] - at least one flushing position, in which the passageway is fluidically connected via a flushing channel to the flushing outlet in such a way that the flushing liquid can be conveyed through the valve

2018204614 25 Jun 2018 outlet and so residues of the first and/or second medicament liquid can be flushed out of the passageway and the valve outlet.

[0009] A medical valve system of the type in question is known from WO 2016/037648 Al and is provided for the serial delivery of medicaments in infusion therapy. In the known valve system, the flushing inlet is arranged on an outer surface of the valve housing. The flushing outlet is provided on the inner circumferential surface of the housing and is fluidically connected to the flushing inlet. In the flushing position, the flushing liquid thus flows initially through the valve housing radially from the outside inwards, then passes via a first sealing location either directly or via the flushing channel into the passageway on the valve body, flows through the latter radially from the outside inwards and axially from the top downwards, and finally enters through a second sealing location into a valve outlet arranged on the valve housing and is discharged from the valve system through said valve outlet.

[0010] The object of the invention is to make available a medical valve system of the aforementioned type which permits improved leaktightness and, at the same time, optimized utilization of the installation space .

[0011] This object is achieved by the fact that the flushing inlet and the valve outlet are arranged on the valve body. As a result of the solution according to the invention, the valve housing has more available installation space for arrangement of the medicament inlets. Accordingly, an optimized utilization of the installation space is achieved. In this way, additionally potentially untight sealing locations between the valve body and the valve housing can be avoided and, consequently, a risk of leaks can be

2018204614 25 Jun 2018 reduced. Within the meaning of the invention, a valve outlet is to be understood as the last portion of the fluid-conducting geometry of the valve system as seen in the usual direction of flow through the valve system. To this extent, the valve outlet is to be understood as a portion of the fluid-conducting geometry of the valve system through which flushing liquid or medicament liquid leaves the valve system. Advantageously, the valve outlet is formed by a through-opening introduced into the valve body, in particular a bore. Alternatively or additionally, the valve outlet can comprise a sleeve arranged on the valve body, a port, or similar. A flushing inlet within the meaning of the invention is to be understood as a portion of the fluid-conducting geometry of the valve body through which flushing liquid can be conveyed in the flushing position without previously flowing through the valve housing. To this extent, the flushing inlet is to be understood as a through-opening introduced into the valve body, in particular a bore. Within the meaning of the invention, a medicament liquid is to be understood not only as liquid compositions that have a medical action. Rather, the term medicament liquid is to be interpreted broadly and accordingly also includes solutions, contrast media meaning of the invention, blood products, nutrient or similar. Within the the term flushing liquid includes medically neutral liquids that are suitable for flushing through the valve system and/or for administering to a patient. The flushing liquid can preferably be a saline solution. Position and/or direction indicators used in this description, for example top, bottom, front, rear, inner, outer or the like, relate to an imaginary spatial orientation of the valve system in which the rotation axis of the valve body is substantially aligned with the spatial vertical axis and is oriented in such a way that the valve outlet is arranged below the medicament inlets in

2018204614 25 Jun 2018 relation to the spatial vertical axis.

[0012] In one embodiment of the invention, the flushing inlet is arranged on the inner body surface of the valve body, and the flushing outlet is arranged on the outer circumferential surface of the valve body, such that the flushing liquid, in the flushing position, can be conveyed through the valve body from the inside outwards. Advantageously, the flushing inlet is fluidically connected to the flushing outlet via a through bore extending substantially radially with respect to the rotation axis.

[0013]

In a further embodiment of the invention, the valve body has an admission channel, which is fluidically connected to the flushing outlet and extends substantially axially with respect to the rotation axis of the valve body, and also an output channel which is fluidically connected to the passageway and the valve outlet and extends substantially axially with respect to the admission channel. This accordingly results in an aligned and vertical orientation of a hose admission line and a hose output line that are connectable, respectively, to the admission channel and the output channel. This embodiment of the invention accordingly permits an optimized arrangement of these hose lines in fluidic terms and therefore an optimized flow through the valve system. The admission channel and the output channel are separated from each other in a fluid-tight manner by a partition wall, in such a way that a direct crossover of the flushing liquid from the admission channel into the output channel (bypassing the flushing outlet, the flushing channel and the passageway) is prevented. The admission channel is fluidically connected to the flushing outlet via the flushing inlet.

[0014] In a further embodiment of the invention, the flushing outlet is arranged below the passageway, wherein the valve body has a first transfer channel, which fluidically connects the flushing inlet to the admission channel, and a second transfer channel, which

2018204614 25 Jun 2018 fluidically connects the passageway to the output channel, and wherein the transfer channels are arranged at least in part next to each other in the axial direction of the valve body. A functionally correct pathway of fluid is achieved in this way.

[0015] In a further embodiment of the invention, the first transfer channel and the second transfer channel extend substantially parallel to each other at least in part and are separated from each other by a substantially axially extending partition wall.

[0016] In a further embodiment of the invention, the first transfer channel and/or the second transfer channel extends at an inclination with respect to the rotation axis.

[0017] In a further embodiment of the invention, the flushing channel is formed annularly between the inner circumferential surface of the housing and the outer circumferential surface of the body. Accordingly, almost complete filling of the flushing channel with the flushing liquid can be achieved, and a risk of unfilled regions can be reduced. The formation of undesired air inclusions, which are a potential danger to a patient, in the fluid-conducting geometry of the valve system is thus avoided, and a valve system is obtained that is particularly safe to use. The annular shape of the flushing channel can advantageously be achieved by a corresponding arrangement of the flushing outlet and of the passageway, wherein in particular a kind of flow obstacle can be arranged between the flushing outlet and the passageway.

2018204614 25 Jun 2018 [0018] In a further embodiment of the invention, the valve body has at least one radial protrusion, which is arranged on the circumferential surface of the body in such a way that at least one flow obstacle is formed in the flushing channel. The flow obstacle is advantageously arranged in such a way that a fluidic short circuit between the flushing outlet and the passageway is avoided. Accordingly, the protrusion at least partially closes the cross section of a flushing channel portion. This embodiment of the invention achieves improved filling of the flushing channel with the flushing liquid and, ultimately, enhanced safety of use .

[0019] In a further embodiment of the invention, a first latch connection between the valve housing and the valve body is provided, for securing the valve body in terms of rotation on the valve housing. Accordingly, the first latch connection permits a defined rotary orientation of the valve body relative to the valve housing, in particular in the flushing position and/or the first and the second medicament position. This counteracts unwanted departure from the flushing position and/or the medicament positions and permits enhanced safety of use of the valve system.

[0020] In a further embodiment of the invention, a second latch connection between the valve housing and the valve body is provided, which is arranged in such a way that the valve body is rotatable only in one direction of rotation about the rotation axis. Accordingly, the second latch connection can permit a predefined sequence of valve body positions that can be adopted in series. It is in this way possible to counteract an inadvertent turning back of the valve body, for example to a medicament position that has already been adopted before. This embodiment of the

2018204614 25 Jun 2018 valve system according to the invention is one that is particularly safe to handle.

[0021] In a further embodiment of the invention, the first and/or second latch connection respectively have/has a profile arranged peripherally on a circumferential surface of the valve body. The profile can have radial protrusions and/or radial depressions.

[0022] In a further embodiment of the invention, the valve body has at least one manually actuatable unlocking element, which is configured in such a way that the profile is elastically radially expansible and in such a way that the first and/or second latch connection between the valve body and the valve housing is releasable. Accordingly, the unlocking element can be shifted between a locking position, in which the first and/or second latch connection is locked immovably, and an unlocking position, in which the first and/or second latch connection is movable. Advantageously, the valve body has two unlocking elements, wherein one unlocking element is assigned to the first latch connection and the other unlocking element is assigned to the second latch connection. Alternatively or additionally, the unlocking element can be arranged on the valve housing. This counteracts unwanted release of the first and/or second latch connection .

[0023] In a further embodiment of the invention, a first attachment sleeve with a longitudinal bore for receiving a flushing liquid admission line in a fluidtight manner is provided, wherein the longitudinal bore is fluidically connected to the flushing inlet, and wherein the first attachment sleeve is secured on the valve body at the end face, and coaxially with respect to the rotation axis, in such a way that the valve body is rotatable relative to the first attachment sleeve.

2018204614 25 Jun 2018

Advantageously, the flushing liquid admission line can be a hose line. The thus rotatable first attachment sleeve on the one hand counteracts an unwanted rotation of the flushing liquid admission line by a rotation of the valve body and on the other hand counteracts an unwanted rotation of the valve body by a rotation of the flushing liquid admission line. This embodiment of the invention permits enhanced safety of use of the valve system according to the invention.

[0024] In a further embodiment of the invention, a second attachment sleeve with a longitudinal bore for receiving a valve output line in a fluid-tight manner is provided, wherein the longitudinal bore is fluidically connected to the passageway, and the second attachment sleeve is secured on the valve body at the end face, and coaxially with respect to the rotation axis, in such way that the valve body is rotatable relative to the second attachment sleeve .

Advantageously, the valve output line can be a hose line. The thus rotatable second attachment sleeve on the one hand counteracts an unwanted rotation of the valve output line by a rotation of the valve body and on the other hand counteracts an unwanted rotation of the valve body by a rotation of the valve output line.

This embodiment of the invention again permits enhanced safety of use of the valve system according to the invention .

[0025] In a further embodiment of the invention, the first attachment sleeve and/or the second attachment sleeve are/is secured in a rotationally fixed manner on the valve housing. Secured in a rotationally fixed manner means that a rotation between the first and/or second attachment sleeve and the valve housing is suppressed. Accordingly, the flushing liquid admission line or valve output line connectable to the respective attachment sleeve is joined in a rotationally rigid manner to the valve housing. This therefore counteracts an unwanted rotation of the flushing liquid admission line and/or of the valve output line by a rotation of the valve body between the different positions.

2018204614 25 Jun 2018 [0026] In a further embodiment of the invention, the first and/or second attachment sleeve in each case have/has a cover plate, the latter being arranged in such a way that a respective radial gap formed between the valve body and the valve housing is covered at the end face. Such a radial gap can be poorly accessible for cleaning purposes, and an undesired accumulation of microorganisms may therefore arise that potentially poses a danger to health. This is counteracted by such an embodiment of the invention.

[0027] In a further embodiment of the invention, the valve body has a connection channel, which is fluidically connected to the flushing channel in at least one of the medicament positions, and the second attachment sleeve has a transverse bore which reaches from the outer circumferential surface of the attachment sleeve into the longitudinal bore thereof, wherein the second attachment sleeve, proceeding from the respective medicament position of the valve body, is rotatable relative to the latter into a back-priming position in which the transverse bore is fluidically connected to the connection channel. This embodiment of the invention permits back-flushing of the respective medicament inlet with flushing liquid. When the valve body is located in one of the medicament positions and the second attachment sleeve is in the priming position, a fluid-conducting connection is thus established between the flushing inlet, the flushing outlet, the flushing channel, the connection channel, the transverse bore and the longitudinal bore of the second attachment sleeve and the passageway, the respective medicament outlet and the corresponding

2018204614 25 Jun 2018 medicament inlet. Along this fluid-conducting connection, flushing liquid can accordingly be flushed out through the medicament inlet and the latter thus primed. For this purpose, the valve outlet or the valve output line is advantageously closed, for example by means of a stopper or a clamp or the like.

[0028] In a further embodiment of the invention, a sealing element is provided which is arranged between the outer circumferential surface of the body and the inner circumferential surface of the housing and serves to seal a radial gap between the valve body and the valve housing. The sealing element can advantageously have rubber-elastic material properties and accordingly an elastomeric material composition. In this way, particularly reliable sealing of the valve system can be achieved, particularly by comparison with the outer circumferential surface of the body simply being pressed onto the inner circumferential surface of the housing.

[0029] In a further embodiment of the invention, a cover device arranged on the end face of the valve housing is provided, having a main body with a throughopening for receiving a hose line and at least one cover element arranged in the region of at least one of the medicament inlets, which cover element is configured in such a way that it limits the manual accessibility to the medicament inlet. The cover device can advantageously be configured as a separate structural element that is connectable to the valve housing. The cover element is advantageously configured as an injection-moulded part and has a plastic material composition. This embodiment of the invention counteracts an unwanted release of medicament admission lines connectable to the medicament inlets, thereby providing a valve system that is particularly safe to use .

2018204614 25 Jun 2018 [0030] In a further embodiment of the invention, the cover element has a connection means which is configured in such a way that a medicament admission line can be locked with form-fit engagement on the cover element. For this purpose, the cover element can advantageously have a clamping or latching unit which is releasably connectable to a portion of the medicament admission line.

[0031] In a further embodiment of the invention, the cover element is secured on the main body, in a manner pivotable relative to the latter, by means of a securing means, in particular by means of a film hinge. Advantageously, the cover element is relatively pivotable in such a way between a locking position, in which the cover element is secured to the portion of the medicament admission line, and a release position, in which no such securing is present.

[0032] Further advantages and features of the invention will become clear from the claims and from the following description of preferred illustrative embodiments of the invention that are shown in the drawings .

[0033] Fig. 1 shows a schematic perspective view of a first embodiment of a valve system according to the invention, [0034] Fig. 2 shows a schematic perspective view of the valve housing of the valve system of Fig. 1, from an upper perspective, [0035] Fig. 3 shows the valve housing of Fig. 2 from a lower perspective, [0036] Fig. 4 shows a schematic perspective sectional view of the valve housing of Figures 2 and 3,

2018204614 25 Jun 2018 [0037] Fig. 5 shows a schematic perspective view of the valve body of the valve system from Fig. 1, [0038] Figures 6 and 7 each show a schematic perspective sectional view of the valve body from Fig. 5, in a first section plane (Fig. 6), and in a section plane rotated through approximately 90° with respect to the latter (Fig. 7), [0039] Figures 8 and 9 each show a schematic perspective sectional view of the valve system from Fig. 1, along a first section plane (Fig. 8) and a section plane rotated through approximately 90° with respect to the latter (Fig. 9), [0040] Fig. 10 shows a schematic perspective view of a first latching region of the valve system according to Figures 1, 8 and 9, [0041] Fig. 11 shows a schematic perspective view of a second latching region of the valve system according to Figures 1, 8 and 9, [0042] Fig. 12 shows a schematic side view of a second embodiment of a valve system according to the invention, [0043] Figures 13 and 14 each show a schematic longitudinal sectional view of the valve system from Fig. 12 in a medicament position (Fig. 13) and in a flushing position (Fig. 14), [0044] Fig. 15 shows a schematic side view of a third embodiment of a valve system according to the invention, [0045] Fig. 16 shows a schematic longitudinal sectional view of the valve system from Fig. 15 in a medicament position, [0046] Fig. 17 shows a schematic perspective view of a fourth embodiment of a valve system according to the invention,

2018204614 25 Jun 2018 [0047] Fig. 18 shows a schematic side view of the valve system from Fig. 17, [0048] Fig. 19 shows a schematic cross-sectional view of the valve system from Figures 17 and 18 in a section plane F-F, [0049] Fig. 20 shows a schematic longitudinal sectional view of the valve system from Figures 17 to in a section plane G-G, [0050] Fig. 21 shows a schematic longitudinal sectional view of the valve system from Figures 17 to in a section plane E-E, [0051] Fig. 22 shows a schematic plan view of a fifth embodiment of a valve system according to the invention, [0052] Fig. 23 shows a schematic longitudinal sectional view of the valve system from Fig. 22 in a section plane T-T, [0053] Fig. 24 shows a schematic perspective view of a cover device of a valve system according to the invention, [0054] Fig. 25 shows a schematic perspective view of a sixth embodiment of a valve system according to the invention, having the cover device from Fig. 24, and

2018204614 25 Jun 2018 [0055] Fig. 26 shows a schematic longitudinal sectional view of a sixth embodiment of a valve system according to the invention, having a sealing element.

[0056] Figures 1 to 26 show various medical valve systems 1 to If according to the invention, which are provided in particular for use in infusion therapy. The valve systems 1 to If are particularly advantageous for the administration of cytostatics.

[0057] Each of the valve systems 1 to If has a valve housing 2 to 2f and a valve body 3 to 3f. The structural and functional set-up of the valve housings 2 to 2f and of the valve bodies 3 to 3f is largely identical in the various valve systems 1 to If. The substantially identical features of the valve housings 2 to 2f and of the valve bodies 3 to 3f are therefore explained in detail below on the basis of the valve housing 2 and of the valve body 3 of the valve system 1 according to Figures 1 to 11. A person skilled in the art may easily transfer these features to the remaining valve systems la to If according to the invention, for which reason these features are not separately explained in connection with these embodiments.

[0058] As will be seen in particular from Figures 2 to 4, the valve housing 2 has several medicament inlets El to E4. The medicament inlets El to E4 are each provided to receive a medicament liquid and are fluidically connected in each case to a medicament outlet Al to A4 arranged on an inner circumferential surface 4 of the valve housing. The medicament inlets El to E4 are arranged on attachment nozzles SI to S4 which protrude radially from the main body of the valve housing 2 and which are in the form of longitudinal bores. At the end face, the attachment nozzles SI to S4 are each provided with an attachment thread (not shown in any detail) for connection to hose lines (not shown in any detail) for

2018204614 25 Jun 2018 the admission of the respective medicament liquid. Alternatively or additionally to the attachment thread, it is possible for the attachment nozzles SI to S4 to be provided with other types of attachment geometries or with adhesively affixed hose sections. The valve housing 2 moreover has a holding element 5 protruding radially from the main body of the valve housing 2. A through-bore 6 of substantially circular cylindrical configuration extends between the two end-face regions of the valve housing 2. This through-bore 6 is provided to at least partially receive the valve body 3. Particularly for this purpose, an axial portion of the through-bore 6 can have a first diameter dimension and a further axial portion can have a second diameter dimension, such that the through-bore 6 can as it were be stepped.

[0059] The valve body 3 is shown in more detail particularly in Figures 5 to 7 and has an outer circumferential surface 7 of the body intended to be received in the through-bore 6 of the valve housing 2. The valve body 3 has a flushing outlet 8 arranged on the outer circumferential surface 7 of the body. The flushing outlet 8 is fluidically connected to a flushing inlet 10 arranged on an inner surface 9 of the body. The fluidic connection between the flushing inlet 10 and the flushing outlet 8 has to this extent the shape of a transverse bore which extends, at least in part, in substantially a radial direction through a wall region of the valve body 3. An admission channel 12 extending in an upper region of the valve body 3 is oriented substantially axially with respect to the rotation axis of the valve body 3 and is fluidically connected to the flushing outlet 8 via the flushing inlet 10. In a lower region of the valve body, an output channel 13 is provided which extends substantially axially with respect to the rotation axis of the valve body 3 and which is fluidically connected

2018204614 25 Jun 2018 to the passageway 11. The lower end-face region of the output channel 13 forms the valve outlet 19 of the valve system 1. By means of a wall region arranged between the admission channel 12 and the output channel 13 of the valve body 3, a direct fluidic connection between admission channel 12 and output channel 13 is suppressed. As will be seen from Figures 6 and 7, the flushing outlet 8 is arranged below the passageway 11 in the axial direction of the valve body 3. Moreover, the valve body 3 has a first transfer channel 14, which fluidically connects the flushing inlet 10 to the admission channel 12. Moreover, a second transfer channel 15 is provided which fluidically connects the passageway 11 to the output channel 13. The two transfer channels 14 and 15 extend substantially in the axial direction of the valve body 3 and at least in part run alongside each other in the axial direction.

[0060] Particularly in the valve system 1 and also in the valve system la (Figures 13 and 14), the first transfer channel 14, 14a and the second transfer channel 15, 15a extend parallel to each other and are separated from each other by a substantially axially extending partition wall 16, 16a. By contrast, in the valve system lb according to Figures 15 and 16, the first transfer channel 14b and the second transfer channel 15b extend at an inclination with respect to the rotation axis of the valve body 3b and also with respect to each other, in the sense of not being parallel to each other.

[0061] The valve body 3 moreover has a protrusion 17 which extends radially from the outer circumferential surface 7 of the body and which extends tangentially along a portion of the outer circumferential surface 7 of the body between the flushing outlet 8 and the passageway 11. A handling element 18, which protrudes both axially and also radially, is futhermore provided at a lower end-face region of the valve body 3.

2018204614 25 Jun 2018 [0062] In a state when arranged in the valve housing 2, the valve body 3 is rotatable, relative to the inner circumferential surface 4 of the housing, to several medicament positions and at least one flushing position. Advantageously, the valve body 3 can be joined at least in part to the valve housing 2 by means of an interference fit or transition fit, such that fluid is prevented from emerging at locations of the valve system 1 where this is not intended to occur. In a medicament position, for example as shown in Fig. 13 for the valve system la, the passageway 11a is fluidically connected to one of the medicament outlets Ala, such that the respective medicament liquid can be conveyed through the valve outlet 19a arranged in the valve body 3a. A medicament position of this kind is shown analogously in connection with the valve system lb according to the invention in Fig. 16 and the valve system lc in Fig. 20. This functionality can to this extent be transferred analogously to the other valve systems 1, Id to If according to the invention, for which reason a separate explanation is not required in connection with these embodiments.

[0063] Moreover,	the valve	bodies 3	to 3f of	the	valve
systems 1	to	If	according	to the	invention	are	each
rotatable	to	at	least one	flushing	position .	One	such
position	can	be	seen in	connection with	the	valve

system 1 according to Figures 8 and 9. In this rotation position of the valve body 3, a fluidic connection is established between the admission channel 12 and the output channel 13 and, to this extent, with the valve outlet 19 arranged at the end face on the valve body 3. Starting from the admission channel 12, this fluidic connection runs through the first transfer channel 14 into the flushing inlet 10, from the latter through the

2018204614 25 Jun 2018 flushing outlet 8 into a flushing channel K, which extends annularly between the inner circumferential surface 4 of the housing and the outer circumferential surface 7 of the body, onwards into the passageway 11, and from the latter into the second transfer channel 15 into the output channel 13 and the valve outlet 19. In this way, any medicament residues can be flushed out of the passageway 11 and the valve outlet and out of the second transfer channel 15 and the output channel 13. The flushing liquid here flows radially through the valve body 3 to 3f from the inside outwards between the flushing inlet 10 and the flushing outlet 8.

[0064] The radial protrusion 17 of the valve body 3 is arranged on the circumferential surface 7 of the body in such a way that a flow obstacle is formed in the flushing channel K. Accordingly, this flow obstacle at least partially closes the cross section of a flushing channel portion (not shown in any detail) and in this way permits a functionally correct pathway of the fluid along the flushing channel K.

[0065] The valve system 1 moreover has a first latch connection 20 between the valve housing 2 and the valve body 3, for securing the valve body 3 in terms of rotation on the valve housing 2. As will be seen in particular from Fig. 10, the first latch connection 20 is formed on the upper end-face region of the valve system 1 and comprises a profile 21 formed on an outer circumferential surface of the valve body 3. The profile 21 is configured in the manner of a toothing and is in latched connection with a profile 22 of complementary form arranged on an inner circumferential surface of the valve housing 2. The profile 22 comprises two latching lugs 23 which engage on sides of the profile 21 lying opposite in the circumferential direction. The latching lugs 23 can advantageously be configured to be elastically deformable. The first

2018204614 25 Jun 2018 latch connection 20 permits a defined rotary orientation of the valve body 3 relative to the valve housing 2, in particular in the flushing position and/or the respective medicament position.

[0066] The valve system 1 moreover comprises a second latch connection 24 (Fig. 11) . The second latch connection 24 is formed in a lower region of the valve system 1 between the valve body 3 and the valve housing 2 and comprises a profile 25, formed on an outer circumferential surface of the valve housing 2, and a profile 26 formed on an inner circumferential surface of the valve body. The second profile 24 is preferably configured in such a way that the valve body 3 is rotatable only in one direction of rotation about the rotation axis.

[0067] The structural and functional set-up of the first and second latch connections 20, 24 explained with reference to the valve system 1 can be readily transferred analogously to the other valve systems la to If according to the invention. The valve systems le and If according to Figures 25 and 26, respectively, have to this extent a second profile 24e, 24f, each of these operatively connected to an unlocking element 27e, 27f arranged on the valve body 3e, 3f. The unlocking elements 27e, 27f each comprise two actuation limbs 28e, 28f protruding axially from the valve body

3e, 3f. When these actuation limbs 28e, 28f are pressed together, the profile 26e, 26f of the second latch connection 24e, 24f is elastically expansible via a rotation point D and to this extent as it were in the manner of a lever. By means of this elastic expansion, the second latch connection 24e, 24f can be released and the valve body 3e, 3f can be positioned in rotation relative to the valve housing 2e, 2f.

2018204614 25 Jun 2018 [0068] The valve system la according to Figures 12 to 14 moreover has a first attachment sleeve 29 with a longitudinal bore 30 for receiving a flushing liquid admission line 31 in a fluid-tight manner. The first attachment sleeve 29 is fixed at its outer circumference radially in the admission channel 12a of the valve body 3a. The inner circumferential surface of the first attachment sleeve 29 encloses a portion of the flushing liquid admission line 31 configured as a hose line. Moreover, the first attachment sleeve 29 is fixed at its end face on the valve body 3a and oriented coaxially with respect to the rotation axis thereof and is rotatable in the admission channel 12a of the valve body 3a. Such an arrangement of the first attachment sleeve 29 counteracts unwanted rotation of the valve body 3a by rotation of the flushing liquid admission line 31 and vice versa.

[0069] Moreover, a second attachment sleeve 32 with a longitudinal bore 33 for receiving a valve output line 34 in a fluid-tight manner is provided. The outer circumferential surface of the second attachment sleeve 32 is secured radially in the output channel 13a of the valve body 3a. The valve output line 34 configured in the form of a hose line is plugged into the longitudinal bore 33 of the second attachment sleeve 32 and, along a portion of its circumferential surface of the hose, is to this extent secured radially on the inner circumferential surface of the second attachment sleeve 32.

The longitudinal bore is fluidically connected to the passageway 11a of

The second attachment sleeve 32 is the valve body 3a.

fixed on the valve body 3a on the end face and coaxially with respect to the rotation axis of the valve body 3a. The second attachment sleeve 32 is to this extent rotatable in the output channel 13a.

2018204614 25 Jun 2018

[0070] Both	the	first	attachment	sleeve 29	and	the
second attachment	sleeve	32 have a	cover plate	35,	36,
respectively.	These cover plates	35, 36 are	in	each
case arranged	in	such a	way that	they cover	a radial

gap 37, 38 formed between the valve body 3a and the valve housing 2a on the end face. Alternatively or additionally, the attachment sleeves 29 and 32 can each be secured against rotation on the valve housing 2a.

[0071] The valve systems lb and If each have a first attachment sleeve 29b, 29f. The first attachment sleeve 29b, 29f has an extension region 39b, 39f, respectively, which extends axially over the end-face region of the valve body 3b, 3f. Similarly, the respective second attachment sleeve 32b, 32f is

equipped with respectively.	a lower	extension	region 40b,	40f,
[0072] In the	valve	system Id	according to	the
invention in	Figures	22 and	23, provision	is
additionally made that	the valve body 3d has a

connection channel 41. In the medicament position of the valve system Id shown in Fig. 23, the connection channel 41 is fluidically connected to the flushing channel Kd. Moreover, the second attachment sleeve 32d has a transverse bore 42 branching off radially from the longitudinal bore 33d. The second attachment sleeve 32 is secured on the valve body 3d, in a manner coaxial to the rotation axis of the latter, and to this extent is rotatable relative thereto. In the function position of the valve system Id shown in Fig. 23, the so-called back-priming position, the transverse bore 42 is fluidically connected to the connection channel 41. This configuration of the valve system Id permits backflushing of the medicament inlet Eld with flushing liquid. For this purpose, the valve outlet 19d, or a valve output line not shown in detail in Fig. 23, is first of all closed, for example with a clamp. The

2018204614 25 Jun 2018 flushing liquid can then pass into the medicament inlet Eld via the fluidic connection between the admission channel 12d, the flushing inlet, the flushing outlet, the flushing channel K, the connection channel 41 of the transverse bore 42, the longitudinal bore 33d, the second transfer channel 15d and the passageway lid via the medicament outlet Aid. The medicament inlet Eld can in this way be back-flushed with flushing liquid. By a rotational displacement of the second attachment sleeve 32d relative to the valve body 3d, the fluidic connection between the transverse bore 42 and the connection channel 41 can be cancelled. Thereafter, the valve system Id is located in a medicament position in which medicament liquid can pass via the medicament inlet Eld through the medicament outlet Aid and the passageway lid into the second transfer channel 15d and from there onwards through the longitudinal bore 33d as far as the valve outlet 19d formed by the end-face region of the second attachment sleeve 32d.

[0073] In order to ensure improved sealing between the valve body 3f and the valve housing 2f, the valve system If according to the invention has a sealing element 43. The sealing element 43 is arranged radially between the valve body 3f and the valve housing 2f and has an elastomeric material composition.

[0074] The valve system le according to the invention shown in Fig. 25 has a cover device 44. The cover device 44 is shown in more detail in Fig. 24 and has a main body 45 with a through-opening 46 for receiving a hose line and with a number of cover elements 47 (in this case four) corresponding to the number of medicament inlets Ele to E4e and arranged in a star shape around the main body 45. The through-opening 46 is provided with a radial slit 48, such that the cover device 44 can be pushed radially over any flushing liquid line of the valve system le. At their end faces,

2018204614 25 Jun 2018 the cover elements 47 have semicircular recesses, which are provided to receive medicament admission lines that are connectable to the medicament inlets Ele to E4e. As will be seen from Fig. 25, the cover elements 47 are configured and arranged in such a way that the manual accessibility to the medicament inlets Ele to E4e is limited. This counteracts unwanted release of the medicament admission lines from the medicament inlets Ele to E4e. The cover elements 47 are in each case connected to the main body 45 via a securing means in the form of a film hinge 49 and are pivotable relative to said main body 45. To this extent, the cover elements 47 can be pivoted upwards via the film hinges 49 in order to attach medicament admission lines to the respective medicament inlets Ele to E4e. After the medicament admission lines have been attached, the cover elements 47 can accordingly be pivoted downwards. In the downwardly pivoted position, the cover elements 47 are connected to the main body 45 in each case via a connection means 50. The connection means 50 each have a latch element 51, arranged laterally on the cover element 47, and a latch pocket 52 arranged on the main body 45.

[0075] In contrast to the valve systems 1 to lb and Id to If, the valve system lc according to Figures 17 to 21 has a radial offset between the admission channel 12c and the output channel 13c. The admission channel 12c is arranged on the valve body 3c as a sleeve 53 extending upwards in the axial direction. Advantageously, the sleeve 53 can be formed integrally with the valve body 3c. To connect the valve body 3c to a flushing liquid admission line (not shown in any detail), the sleeve 53 is plugged into the flushing liquid admission line. A particularly short configuration of the valve system lc can be achieved in this way. Advantageously, the flushing liquid admission line can be bonded to the sleeve 53.

2018204614 25 Jun 2018 [0076] Throughout this specification and the claims which follow, unless the context requires otherwise, the word comprise, and variations such as comprises and comprising, will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.

[0077] The reference in this specification to any prior publication (or information derived from it) , or to any matter which is known, is not, and should not be taken as an acknowledgment or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general knowledge in the field of endeavor to which this specification relates.

[0078] The reference numerals in the following claims do not in any way limit the scope of the respective claims .

Claims

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:

1. Medical valve system (1 to If) for administering at least two medicament liquids, having

- a valve housing (2 to 2f) with at least two medicament inlets (El to E4) which each receive one of the medicament liquids and which are fluidically connected in each case to a medicament outlet (Al to A4) arranged on an inner circumferential surface (4) of the housing,

- a valve body (3 to 3f) which is arranged at least partially in the valve housing (2 to 2f) and which is rotatable about a rotation axis relative to the inner circumferential surface (4) of the housing, with an outer circumferential surface (7) of the body and an inner body surface (9) and with a passageway (11, 11a, 11c, lid) arranged on the outer circumferential surface (7) of the body,

- a flushing inlet (10) which receives a flushing liquid and which is fluidically connected to a flushing outlet (8), and

- a valve outlet (19, 19a, 19c, 19d) which discharges the flushing liquid and/or at least one of the medicament liquids and which is fluidically connected to the passageway (11, 11a, 11c, lid),

- wherein the valve body (3 to 3f) is rotatable to

- at least two medicament positions, in which the passageway (11, 11a, 11c, lid) is in each

2018204614 25 Jun 2018 case fluidically connected to one of the medicament outlets (Al to A4) in such a way that the respective medicament liquid can be conveyed through the valve outlet (19, 19a,

19c, 19d), and

- at least one flushing position, in which the passageway (11, 11a, 11c, lid) is fluidically connected via a flushing channel (K, Ka, Kd) to the flushing outlet (8) in such a way that the flushing liquid can be conveyed through the valve outlet (19, 19a, 19c, 19d) and so residues of the first and/or second medicament liquid can be flushed out of the passageway (11, 11a, lc, lid) and the valve outlet (19, 19a, 19c, 19d), characterized in that the flushing inlet (10) and the valve outlet (19, 19a, 19c, 19d) are arranged on the valve body (3 to 3f).
2. Medical valve system (1 to If) according to Claim

1, characterized in that the flushing inlet (10) is arranged on the inner body surface (9) of the valve body (3 to 3f) , and the flushing outlet (8) is arranged on the outer circumferential surface (7) of the valve body (3 to 3f) , such that the flushing liquid, in the flushing position, can be conveyed through the valve body (3 to 3f) from the inside outwards.
3. Medical valve system (1 to If) according to Claim

1 or 2, characterized in that the valve body (3 to

3f) has an admission channel (12, 12a, 12c), which is fluidically connected to the flushing outlet (8) and extends substantially axially with respect to the rotation axis of the valve body (3 to 3f) , and also an output channel (13, 13a, 13c) which is

2018204614 25 Jun 2018 fluidically connected to the passageway (11, 11a,

11c, lid) and the valve outlet (19, 19a, 19c, 19d) and extends substantially axially with respect to the admission channel (12, 12a, 12c) .
4. Medical valve system (1 to If) according to Claim

3, characterized in that the flushing outlet (8) is arranged below the passageway (11, 11a, 11c, lid) , wherein the valve body (3e to 3f) has a first transfer channel (14 to 14b), which fluidically connects the flushing inlet (10) to the admission channel (12, 12a, 12c), and a second transfer channel (15 to 15b), which fluidically connects the passageway (11, 11a, 11c, lid) to the output channel (13, 13a, 13c), and wherein the transfer channels are arranged at least in part next to each other in the axial direction of the valve body (3 to 3f).
5. Medical valve system (1, la, lc to If) according to Claim 4, characterized in that the first transfer channel (14, 14a) and the second transfer channel (15, 15a) extend substantially parallel to each other at least in part and are separated from each other by a substantially axially extending partition wall (16, 16a).
6. Medical valve system (lb) according to Claim 4, characterized in that the first transfer channel (14b) and/or the second transfer channel (15b) extends at an inclination with respect to the rotation axis.
7. Medical valve system (1 to If) according to one of the preceding claims, characterized in that the flushing channel (K, Ka, Kd) is formed annularly between the inner circumferential surface (4) of

2018204614 25 Jun 2018 the housing and the outer circumferential surface (7) of the body.
8. Medical valve system (1 to If) according to Claim 7, characterized in that the valve body (3 to 3f) has at least one radial protrusion (17), which is arranged on the circumferential surface (7) of the body in such a way that at least one flow obstacle is formed in the flushing channel (K, Ka, Kd).
9. Medical valve system (1 to If) according to one of the preceding claims, characterized by a first latch connection (20) between the valve housing (2 to 2f) and the valve body (3 to 3f), for securing the valve body (3 to 3f) in terms of rotation on the valve housing (2 to 2f).
10. Medical valve system (1 to If) according to one of the preceding claims, characterized by a second latch connection (24) between the valve housing (2 to 2f) and the valve body (3 to 3f) , which is arranged in such a way that the valve body (3 to 3f) is rotatable only in one direction of rotation about the rotation axis.
11. Medical valve system (1 to If) according to Claim

9 and/or 10, characterized in that the first and/or second latch connection (20, 24) respectively have/has a profile (21, 26) arranged peripherally on a circumferential surface of the valve body (3 to 3f).
12. Medical valve system (le, If) according to Claim

11, characterized in that the valve body (3e, 3f) has at least one manually actuatable unlocking element (27e, 27f), which is configured in such a way that the profile (21, 26) is elastically radially expansible and in such a way that the

2018204614 25 Jun 2018 first and/or second latch connection (20, 24) between the valve body (3e, 3f) and the valve housing (2e, 2f) is releasable.
13. Medical valve system (la, lb, If) according to one of the preceding claims, characterized by a first attachment sleeve (29, 29b, 29f) with a longitudinal bore (30, 30b, 30f) for receiving a flushing liquid admission line (31) in a fluidtight manner, wherein the longitudinal bore (30, 30b, 30f) is fluidically connected to the flushing inlet (10), and wherein the first attachment sleeve (29, 29b, 29f) is secured on the valve body (3a, 3b, 3f) at the end face, and coaxially with respect to the rotation axis, in such a way that the valve body (3a, 3b, 3f) is rotatable relative to the first attachment sleeve (29, 29b, 29f).
14. Medical valve system (la to Id, If) according to one of the preceding claims, characterized by a second attachment sleeve (32, 32b to 32d, 32f) with a longitudinal bore (33, 33b to 33d, 33f) for receiving a valve output line (34) in a fluidtight manner, wherein the longitudinal bore (33,

33b to 33d, 33f) is fluidically connected to the passageway (11) , and the second attachment sleeve (32, 32b to 32d, 32f) is secured on the valve body (3a to 3d, 3f) at the end face, and coaxially with

respect to the rotation axis, in such a way that the valve body (3a to 3d, 3f) is rotatable relative to the second attachment sleeve (32, 32b to 32d, 32f) .
15.

Medical according to

Claim 13 and/or

14, characterized in that the first attachment sleeve and/or the second attachment are/is secured in a rotationally fixed manner on the valve housing (3a) .

2018204614 25 Jun 2018
16. Medical valve system (la) according to one of

Claims 13 to 15, characterized in that the first and/or the second attachment sleeve (29, 32) have/has a respective cover plate (36, 36) , the latter being arranged in such a way that a radial gap (37, 38) formed between the valve body (3a) and the valve housing (2a) is in each case covered at the end face.
17. Medical valve system (Id) according to Claim 14, characterized in that the valve body (3d) has a connection channel (41), which is fluidically connected to the flushing channel (Kd) in at least one of the medicament positions, and in that the second attachment sleeve (32d) has a transverse bore (42) which reaches from the outer circumferential surface of the attachment sleeve (32d) into the longitudinal bore (33d) thereof, wherein the second attachment sleeve (32d) , proceeding from the respective medicament position of the valve body (3d), is rotatable relative to the latter into a back-priming position in which the transverse bore (42) is fluidically connected to the connection channel (41).
18. Medical valve system (If) according to one of the preceding claims, characterized by a sealing element (43) which is arranged between the outer circumferential surface (7) of the body and the inner circumferential surface (4) of the housing and serves to seal a radial gap between the valve body (3f) and the valve housing (2f).
19. Medical (le) valve system according to one of the preceding claims, characterized by a cover device

2018204614 25 Jun 2018 (44) arranged on the end face of the valve housing (2e) and having a main body (45) with a throughopening (46) for receiving a hose line and with at least one cover element (47) arranged in the region of at least one of the medicament inlets (Ele to E4e), which cover element (47) is configured in such a way that it limits the manual accessibility to the medicament inlet (Ele to E4e) .
20. Medical valve system (le) according to Claim 19, characterized in that the cover element (47) has a connection means (50) which is configured in such a way that a medicament admission line can be locked with form-fit engagement on the cover element (47).
21. Medical valve system (le) according to Claim 19 or 20, characterized in that the cover element (47) is secured on the main body (45) , in a manner pivotable relative to the latter, by means of a securing means (49), in particular by means of a film hinge (49) .