AU2017293950B2 - Prevention and treatment of atrial fibrillation/flutter with gamma-ketoaldehyde scavengers - Google Patents

Prevention and treatment of atrial fibrillation/flutter with gamma-ketoaldehyde scavengers Download PDF

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Publication number
AU2017293950B2
AU2017293950B2 AU2017293950A AU2017293950A AU2017293950B2 AU 2017293950 B2 AU2017293950 B2 AU 2017293950B2 AU 2017293950 A AU2017293950 A AU 2017293950A AU 2017293950 A AU2017293950 A AU 2017293950A AU 2017293950 B2 AU2017293950 B2 AU 2017293950B2
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AU
Australia
Prior art keywords
atrial
alkyl
atrial fibrillation
alkoxy
anp
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AU2017293950A
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English (en)
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AU2017293950A1 (en
Inventor
Venkataraman Amarnath
Katherine T. MURRAY
L. Jackson ROBERTS II
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Vanderbilt University
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Vanderbilt University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2017293950A 2016-07-07 2017-07-07 Prevention and treatment of atrial fibrillation/flutter with gamma-ketoaldehyde scavengers Active AU2017293950B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662359705P 2016-07-07 2016-07-07
US62/359,705 2016-07-07
PCT/US2017/041211 WO2018009875A1 (en) 2016-07-07 2017-07-07 Prevention and treatment of atrial fibrillation/flutter with gamma-ketoaldehyde scavengers

Publications (2)

Publication Number Publication Date
AU2017293950A1 AU2017293950A1 (en) 2019-01-31
AU2017293950B2 true AU2017293950B2 (en) 2023-06-15

Family

ID=60913210

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017293950A Active AU2017293950B2 (en) 2016-07-07 2017-07-07 Prevention and treatment of atrial fibrillation/flutter with gamma-ketoaldehyde scavengers

Country Status (11)

Country Link
US (2) US20190247375A1 (cg-RX-API-DMAC10.html)
EP (1) EP3481505B1 (cg-RX-API-DMAC10.html)
JP (1) JP7179353B2 (cg-RX-API-DMAC10.html)
CN (1) CN110022936A (cg-RX-API-DMAC10.html)
AU (1) AU2017293950B2 (cg-RX-API-DMAC10.html)
BR (1) BR112019000251A2 (cg-RX-API-DMAC10.html)
CA (1) CA3030149A1 (cg-RX-API-DMAC10.html)
ES (1) ES3040735T3 (cg-RX-API-DMAC10.html)
MX (1) MX393913B (cg-RX-API-DMAC10.html)
PL (1) PL3481505T3 (cg-RX-API-DMAC10.html)
WO (1) WO2018009875A1 (cg-RX-API-DMAC10.html)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070249562A1 (en) * 2006-04-25 2007-10-25 Friesen Albert D Treatment of atrial fibrillation
WO2011008202A1 (en) * 2009-07-15 2011-01-20 Vanderbilt University Isoketal scavengers and mitigation of disorders involving oxidative injury
US20120157501A1 (en) * 2004-10-20 2012-06-21 Vanderbilt University Isoketal scavengers and mitigation of disorders involving oxidative injury

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6620836B1 (en) * 1997-01-22 2003-09-16 Jay Patrick Antiarrhythmic and tranquilizer composition and treatment
US10975033B2 (en) * 2011-07-12 2021-04-13 Vanderbilt University Methods for treating inflammation and hypertension with γ-ketoaldehyde skavengers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120157501A1 (en) * 2004-10-20 2012-06-21 Vanderbilt University Isoketal scavengers and mitigation of disorders involving oxidative injury
US20070249562A1 (en) * 2006-04-25 2007-10-25 Friesen Albert D Treatment of atrial fibrillation
WO2011008202A1 (en) * 2009-07-15 2011-01-20 Vanderbilt University Isoketal scavengers and mitigation of disorders involving oxidative injury

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SIDOROVA, T.N. et al., "Reactive [gamma]-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, (2014), vol. 79, pages 295 - 302. *

Also Published As

Publication number Publication date
CA3030149A1 (en) 2018-01-11
JP2019520389A (ja) 2019-07-18
BR112019000251A2 (pt) 2019-04-16
US20190247375A1 (en) 2019-08-15
US20240189291A1 (en) 2024-06-13
WO2018009875A1 (en) 2018-01-11
AU2017293950A1 (en) 2019-01-31
EP3481505A4 (en) 2020-02-26
ES3040735T3 (en) 2025-11-04
MX2019000120A (es) 2019-04-01
EP3481505A1 (en) 2019-05-15
JP7179353B2 (ja) 2022-11-29
EP3481505C0 (en) 2025-09-03
CN110022936A (zh) 2019-07-16
PL3481505T3 (pl) 2026-01-26
MX393913B (es) 2025-03-24
EP3481505B1 (en) 2025-09-03

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