AU2017254720B2 - Compounds and methods for treating neurological and cardiovascular conditions - Google Patents

Compounds and methods for treating neurological and cardiovascular conditions Download PDF

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Publication number
AU2017254720B2
AU2017254720B2 AU2017254720A AU2017254720A AU2017254720B2 AU 2017254720 B2 AU2017254720 B2 AU 2017254720B2 AU 2017254720 A AU2017254720 A AU 2017254720A AU 2017254720 A AU2017254720 A AU 2017254720A AU 2017254720 B2 AU2017254720 B2 AU 2017254720B2
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Prior art keywords
disease
agonist
brain
pain
mrs4322
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AU2017254720A1 (en
Inventor
Kenneth A. Jacobson
William S. Korinek
James D. Lechleiter
Theodore E. Liston
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University of Texas System
Astrocyte Pharmaceuticals Inc
US Department of Health and Human Services
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University of Texas System
University of Texas at Austin
Astrocyte Pharmaceuticals Inc
Government of the United States of America
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Priority to AU2023202694A priority Critical patent/AU2023202694B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2017254720A 2016-04-21 2017-04-21 Compounds and methods for treating neurological and cardiovascular conditions Active AU2017254720B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2023202694A AU2023202694B2 (en) 2016-04-21 2023-05-02 Compounds and methods for treating neurological and cardiovascular conditions

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662325860P 2016-04-21 2016-04-21
US62/325,860 2016-04-21
PCT/US2017/028996 WO2017185061A1 (en) 2016-04-21 2017-04-21 Compounds and methods for treating neurological and cardiovascular conditions

Related Child Applications (1)

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AU2023202694A Division AU2023202694B2 (en) 2016-04-21 2023-05-02 Compounds and methods for treating neurological and cardiovascular conditions

Publications (2)

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AU2017254720A1 AU2017254720A1 (en) 2018-11-01
AU2017254720B2 true AU2017254720B2 (en) 2023-02-02

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AU2023202694A Active AU2023202694B2 (en) 2016-04-21 2023-05-02 Compounds and methods for treating neurological and cardiovascular conditions

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US (7) US9789131B1 (https=)
EP (2) EP4414027A3 (https=)
JP (3) JP7109005B2 (https=)
KR (2) KR102445887B1 (https=)
CN (2) CN109310695B (https=)
AU (2) AU2017254720B2 (https=)
CA (1) CA3020490A1 (https=)
EA (1) EA201892008A1 (https=)
ES (1) ES2989621T3 (https=)
IL (2) IL289423B2 (https=)
MX (1) MX391725B (https=)
WO (1) WO2017185061A1 (https=)

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RU2754614C2 (ru) 2016-03-16 2021-09-03 Басф Се Применение тетразолинонов для борьбы с устойчивыми фитопатогенными грибами на злаковых культурах
BR112018068705B1 (pt) 2016-03-16 2022-09-06 Basf Se Método para controlar fungos fitopatogênicos
WO2017157920A1 (en) 2016-03-16 2017-09-21 Basf Se Use of tetrazolinones for combating resistant phytopathogenic fungi on fruits
KR102445887B1 (ko) 2016-04-21 2022-09-21 아스트로사이트 파마슈티컬스, 인코포레이티드 신경계 및 심혈관계 병태 치료를 위한 화합물 및 방법
IL276358B2 (en) * 2018-02-09 2024-11-01 Astrocyte Pharmaceuticals Inc Compounds and methods for treating addiction and related disorders
CA3115555A1 (en) * 2018-05-26 2019-12-05 Primetime Life Sciences, Llc Compounds and methods for modulation of g-protein-coupled receptors
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JP7282324B2 (ja) * 2018-12-11 2023-05-29 株式会社島津製作所 イオン化装置、質量分析装置および流体試料の分析方法
US20220218712A1 (en) * 2019-02-25 2022-07-14 Saint Louis University Treatment of alzheimer's disease
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WO2023091791A1 (en) * 2021-11-22 2023-05-25 Astrocyte Pharmaceuticals, Inc. Methods of treating neurological and cardiovascular conditions
EP4476235A4 (en) * 2022-02-10 2026-02-18 Academia Sinica METHOD FOR TREATMENT OF A SPINAL CORD INJURY AND CORRESPONDING COMPOSITION
WO2024097387A1 (en) * 2022-11-03 2024-05-10 Astrocyte Pharmaceuticals, Inc. Compositions for intravenous administration
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US20220305044A1 (en) 2022-09-29
MX2018012655A (es) 2019-09-06
US10265338B2 (en) 2019-04-23
KR20190006501A (ko) 2019-01-18
CN114903903A (zh) 2022-08-16
IL289423A (en) 2022-02-01
NZ747047A (en) 2025-02-28
EP3445368B1 (en) 2024-07-17
CN109310695A (zh) 2019-02-05
US9789131B1 (en) 2017-10-17
EA201892008A1 (ru) 2019-06-28
EP3445368C0 (en) 2024-07-17
AU2017254720A1 (en) 2018-11-01
US20180021363A1 (en) 2018-01-25
EP3445368A1 (en) 2019-02-27
ES2989621T3 (es) 2024-11-27
IL289423B2 (en) 2026-03-01
US12239654B2 (en) 2025-03-04
CA3020490A1 (en) 2017-10-26
WO2017185061A1 (en) 2017-10-26
KR102445887B1 (ko) 2022-09-21
BR112018071560A2 (pt) 2019-02-12
US12390483B2 (en) 2025-08-19
US20250345353A1 (en) 2025-11-13
JP2019515920A (ja) 2019-06-13
AU2023202694A1 (en) 2023-05-18
IL262487B (en) 2022-02-01
US11484545B2 (en) 2022-11-01
IL289423B1 (en) 2025-11-01
EP4414027A3 (en) 2024-11-13
EP4414027A2 (en) 2024-08-14
MX391725B (es) 2025-03-21
JP7709141B2 (ja) 2025-07-16
US20200046751A1 (en) 2020-02-13
KR20220132042A (ko) 2022-09-29
EP3445368A4 (en) 2019-12-18
US10953031B2 (en) 2021-03-23
AU2023202694B2 (en) 2025-07-10
IL262487A (en) 2018-12-31
JP2025084908A (ja) 2025-06-03
JP7109005B2 (ja) 2022-07-29
JP2022088642A (ja) 2022-06-14
CN109310695B (zh) 2022-04-01
US20230165887A1 (en) 2023-06-01
US20220000899A1 (en) 2022-01-06

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