AU2015346527A1 - Instrument and cartridge for performing assays in a closed sample preparation and reaction system - Google Patents

Instrument and cartridge for performing assays in a closed sample preparation and reaction system Download PDF

Info

Publication number
AU2015346527A1
AU2015346527A1 AU2015346527A AU2015346527A AU2015346527A1 AU 2015346527 A1 AU2015346527 A1 AU 2015346527A1 AU 2015346527 A AU2015346527 A AU 2015346527A AU 2015346527 A AU2015346527 A AU 2015346527A AU 2015346527 A1 AU2015346527 A1 AU 2015346527A1
Authority
AU
Australia
Prior art keywords
fluid
cartridge
cam
chamber
assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2015346527A
Other languages
English (en)
Inventor
Dominic Aiello
Scott Corey
Andrew Fish
Darren Scott GRAY
Jon Faiz Kayyem
Peter Kroehl
George Maltezos
Brian Murphy
Eric Schneider
Jay Srinivasan
David Walter Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genmark Diagnostics Inc
Original Assignee
Genmark Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/538,533 external-priority patent/US9598722B2/en
Priority claimed from US14/538,565 external-priority patent/US9498778B2/en
Application filed by Genmark Diagnostics Inc filed Critical Genmark Diagnostics Inc
Publication of AU2015346527A1 publication Critical patent/AU2015346527A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0721—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis parallel with respect to the rotating axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0724—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis directly mounted on the rotating axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/07—Stirrers characterised by their mounting on the shaft
    • B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
    • B01F27/0725—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis on the free end of the rotating axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/05—Stirrers
    • B01F27/11—Stirrers characterised by the configuration of the stirrers
    • B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
    • B01F27/1125—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis
    • B01F27/11251—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades with vanes or blades extending parallel or oblique to the stirrer axis having holes in the surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/50—Pipe mixers, i.e. mixers wherein the materials to be mixed flow continuously through pipes, e.g. column mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/25—Mixers with loose mixing elements, e.g. loose balls in a receptacle
    • B01F33/251—Mixers with loose mixing elements, e.g. loose balls in a receptacle using balls as loose mixing element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/86—Mixing heads comprising a driven stirrer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/045—Connecting closures to device or container whereby the whole cover is slidable
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B01L2400/0616—Ball valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B01L2400/0683—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers mechanically breaking a wall or membrane within a channel or chamber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AU2015346527A 2014-11-11 2015-11-10 Instrument and cartridge for performing assays in a closed sample preparation and reaction system Abandoned AU2015346527A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14/538,565 2014-11-11
US14/538,533 US9598722B2 (en) 2014-11-11 2014-11-11 Cartridge for performing assays in a closed sample preparation and reaction system
US14/538,565 US9498778B2 (en) 2014-11-11 2014-11-11 Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US14/538,533 2014-11-11
PCT/US2015/059978 WO2016077364A2 (en) 2014-11-11 2015-11-10 Instrument and cartridge for performing assays in a closed sample preparation and reaction system

Publications (1)

Publication Number Publication Date
AU2015346527A1 true AU2015346527A1 (en) 2017-06-29

Family

ID=54608967

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2015346527A Abandoned AU2015346527A1 (en) 2014-11-11 2015-11-10 Instrument and cartridge for performing assays in a closed sample preparation and reaction system

Country Status (5)

Country Link
EP (3) EP3218108B1 (https=)
JP (1) JP2018502309A (https=)
AU (1) AU2015346527A1 (https=)
ES (1) ES3038141T3 (https=)
WO (1) WO2016077364A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP1628115S (https=) 2012-10-24 2019-04-01
US20210016281A1 (en) * 2018-03-22 2021-01-21 Nikon Corporation Fluid device
PL3821223T3 (pl) * 2018-07-10 2025-03-03 Precision Planting Llc Układ do pobierania próbek rolniczych i powiązane sposoby
GB201818412D0 (en) 2018-11-12 2018-12-26 Lumiradx Tech Ltd A magnetic assembly for use in a device for conducting assays
JP7285746B2 (ja) * 2019-09-20 2023-06-02 ニデックプレシジョン株式会社 搬送装置
CN112940061B (zh) 2019-12-10 2024-05-03 财团法人工业技术研究院 核酸萃取装置
TWI742905B (zh) * 2019-12-10 2021-10-11 財團法人工業技術研究院 核酸萃取裝置
EP4244512B1 (en) 2020-11-16 2025-10-01 Siemens Healthcare Diagnostics, Inc. Valve for microfluidic device
WO2022139820A1 (en) * 2020-12-22 2022-06-30 Hp Health Solutions Inc. Devices to control magnetizing microparticles in fluid density columns
WO2023272800A1 (zh) * 2021-07-02 2023-01-05 北京乐普智慧医疗科技有限公司 一种包含提取扩增检测全流程的分子诊断卡及其使用工艺方法
CN113786795B (zh) * 2021-10-21 2022-12-30 广州卡洛莱化妆品有限公司 一种具有滋润皮肤修饰肤色效果的组合物的生产系统
CN113877645A (zh) * 2021-10-29 2022-01-04 深圳迈瑞动物医疗科技有限公司 微流控芯片
US20230181809A1 (en) * 2021-12-13 2023-06-15 Medtronic Xomed, Inc. Surgical devices, systems, and methods facilitating multiple flow path fluid management
EP4587189A4 (en) * 2022-09-16 2026-01-14 Siemens Healthcare Diagnostics Inc IMPROVING THE SIGNAL-TO-NOISE RATIO IN IMMUNOLOGICAL ASSAYS
EP4344776A1 (en) * 2022-09-28 2024-04-03 Gerresheimer Regensburg GmbH Test cartridges and systems
DE102024103863B3 (de) 2024-02-12 2025-01-02 Friz Biochem Gmbh Probenanalysegerät
DE102024208102A1 (de) * 2024-08-26 2026-02-26 Robert Bosch Gesellschaft mit beschränkter Haftung Führungseinrichtung, Analysegerät und Verfahren zum Betreiben eines Analysegeräts

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US5034506A (en) 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
JPS63121024A (ja) * 1986-11-10 1988-05-25 Hitachi Ltd 液晶表示装置
GB8708201D0 (en) 1987-04-06 1987-05-13 Cogent Ltd Gas sensor
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
US5644048A (en) 1992-01-10 1997-07-01 Isis Pharmaceuticals, Inc. Process for preparing phosphorothioate oligonucleotides
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
GB9411515D0 (en) 1994-06-09 1994-08-03 Aromascan Plc Detecting bacteria
GB9412632D0 (en) 1994-06-23 1994-08-10 Aromascan Plc Semiconducting organic polymers
GB9412633D0 (en) 1994-06-23 1994-08-10 Aromascan Plc Semiconducting organic polymers
US5681702A (en) 1994-08-30 1997-10-28 Chiron Corporation Reduction of nonspecific hybridization by using novel base-pairing schemes
GB9425207D0 (en) 1994-12-14 1995-02-15 Aromascan Plc Semi-conducting organic polymers
GB9503760D0 (en) 1995-02-24 1995-04-12 Aromascan Plc Neural networks
US5770365A (en) 1995-08-25 1998-06-23 Tm Technologies, Inc. Nucleic acid capture moieties
GB9523406D0 (en) 1995-11-16 1996-01-17 Aromascan Plc Sensor transduction
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
GB9700012D0 (en) 1997-01-02 1997-02-19 Aromascan Plc Improvements in the detection of bacteria
JP2001513646A (ja) 1997-03-06 2001-09-04 オスメテック パブリック リミテッド カンパニー 微生物分析手段
US5993750A (en) * 1997-04-11 1999-11-30 Eastman Kodak Company Integrated ceramic micro-chemical plant
DK0988534T3 (da) 1997-06-12 2011-05-23 Clinical Micro Sensors Inc Elektroniske fremgangsmåder og apparat til detektering af analytter
US6013459A (en) 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
GB9714166D0 (en) 1997-07-05 1997-09-10 Aromascan Plc Apparatuses and methods for gas sampling
CA2319170A1 (en) 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6063573A (en) 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
GB9805867D0 (en) 1998-03-20 1998-05-13 Aromascan Plc Sensor manufacture
ATE407220T1 (de) 1998-05-06 2008-09-15 Clinical Micro Sensors Inc Elekronische verfahren zur erkennung von analyten mit hilfe von einfachschichten
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US7087148B1 (en) 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
GB9818176D0 (en) 1998-08-21 1998-10-14 Aromascan Plc Method for detecting microorganisms
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US7312087B2 (en) 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6942771B1 (en) 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
WO2001007665A2 (en) 1999-07-26 2001-02-01 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6596483B1 (en) 1999-11-12 2003-07-22 Motorola, Inc. System and method for detecting molecules using an active pixel sensor
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6642046B1 (en) 1999-12-09 2003-11-04 Motorola, Inc. Method and apparatus for performing biological reactions on a substrate surface
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
US6824669B1 (en) 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
US6773566B2 (en) 2000-08-31 2004-08-10 Nanolytics, Inc. Electrostatic actuators for microfluidics and methods for using same
GB0120062D0 (en) 2001-08-17 2001-10-10 Osmetech Plc Detection of bacterial vaginosis
US7351303B2 (en) * 2002-10-09 2008-04-01 The Board Of Trustees Of The University Of Illinois Microfluidic systems and components
EP1859330B1 (en) 2005-01-28 2012-07-04 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
CA2606750C (en) 2005-05-11 2015-11-24 Nanolytics, Inc. Method and device for conducting biochemical or chemical reactions at multiple temperatures
EP1919618A2 (en) 2005-05-21 2008-05-14 Core-Microsolutions, Inc. Mitigation of biomolecular adsorption with hydrophilic polymer additives
WO2006138543A1 (en) 2005-06-16 2006-12-28 Core-Microsolutions, Inc. Biosensor detection by means of droplet driving, agitation, and evaporation
JP2009511059A (ja) * 2005-10-11 2009-03-19 ハンディーラブ インコーポレイテッド ポリヌクレオチドサンプル調製装置
CN101351270A (zh) 2005-10-22 2009-01-21 精华微技有限公司 从用于芯片微流控的液柱中抽取液滴
US8541177B2 (en) 2006-01-13 2013-09-24 A Chan Holding B.V. Treatment and diagnosis of abnormal bone density with an inhibitor of the glypican-sclerostin interaction
ES2692380T3 (es) * 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US8613889B2 (en) 2006-04-13 2013-12-24 Advanced Liquid Logic, Inc. Droplet-based washing
US8637317B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Method of washing beads
US8492168B2 (en) 2006-04-18 2013-07-23 Advanced Liquid Logic Inc. Droplet-based affinity assays
US9476856B2 (en) 2006-04-13 2016-10-25 Advanced Liquid Logic, Inc. Droplet-based affinity assays
US7763471B2 (en) 2006-04-18 2010-07-27 Advanced Liquid Logic, Inc. Method of electrowetting droplet operations for protein crystallization
US8980198B2 (en) 2006-04-18 2015-03-17 Advanced Liquid Logic, Inc. Filler fluids for droplet operations
US7816121B2 (en) 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet actuation system and method
US8809068B2 (en) 2006-04-18 2014-08-19 Advanced Liquid Logic, Inc. Manipulation of beads in droplets and methods for manipulating droplets
US7439014B2 (en) 2006-04-18 2008-10-21 Advanced Liquid Logic, Inc. Droplet-based surface modification and washing
US7727723B2 (en) 2006-04-18 2010-06-01 Advanced Liquid Logic, Inc. Droplet-based pyrosequencing
US8716015B2 (en) 2006-04-18 2014-05-06 Advanced Liquid Logic, Inc. Manipulation of cells on a droplet actuator
US8637324B2 (en) 2006-04-18 2014-01-28 Advanced Liquid Logic, Inc. Bead incubation and washing on a droplet actuator
US8470606B2 (en) 2006-04-18 2013-06-25 Duke University Manipulation of beads in droplets and methods for splitting droplets
US8658111B2 (en) 2006-04-18 2014-02-25 Advanced Liquid Logic, Inc. Droplet actuators, modified fluids and methods
US7901947B2 (en) 2006-04-18 2011-03-08 Advanced Liquid Logic, Inc. Droplet-based particle sorting
WO2009140671A2 (en) 2008-05-16 2009-11-19 Advanced Liquid Logic, Inc. Droplet actuator devices and methods for manipulating beads
US7815871B2 (en) 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet microactuator system
WO2007123908A2 (en) 2006-04-18 2007-11-01 Advanced Liquid Logic, Inc. Droplet-based multiwell operations
US8685754B2 (en) 2006-04-18 2014-04-01 Advanced Liquid Logic, Inc. Droplet actuator devices and methods for immunoassays and washing
US7939021B2 (en) 2007-05-09 2011-05-10 Advanced Liquid Logic, Inc. Droplet actuator analyzer with cartridge
US9675972B2 (en) 2006-05-09 2017-06-13 Advanced Liquid Logic, Inc. Method of concentrating beads in a droplet
US8041463B2 (en) 2006-05-09 2011-10-18 Advanced Liquid Logic, Inc. Modular droplet actuator drive
US7822510B2 (en) 2006-05-09 2010-10-26 Advanced Liquid Logic, Inc. Systems, methods, and products for graphically illustrating and controlling a droplet actuator
US8685344B2 (en) 2007-01-22 2014-04-01 Advanced Liquid Logic, Inc. Surface assisted fluid loading and droplet dispensing
EP2573562A3 (en) 2007-02-09 2013-10-30 Advanced Liquid Logic, Inc. Droplet actuator devices and methods employing magnetic beads
WO2008101196A1 (en) 2007-02-15 2008-08-21 Osmetech Molecular Diagnostics Fluidics devices
EP2109774B1 (en) 2007-02-15 2018-07-04 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
EP2121329B1 (en) 2007-03-01 2014-05-14 Advanced Liquid Logic, Inc. Droplet actuator structures
JP5491203B2 (ja) 2007-03-05 2014-05-14 アドヴァンスト リキッド ロジック インコーポレイテッド 過酸化水素小滴ベースのアッセイ
EP2122327B1 (en) 2007-03-13 2013-12-25 Advanced Liquid Logic, Inc. Method for improving absorbance detection of a droplet
US8202686B2 (en) 2007-03-22 2012-06-19 Advanced Liquid Logic, Inc. Enzyme assays for a droplet actuator
WO2008116221A1 (en) 2007-03-22 2008-09-25 Advanced Liquid Logic, Inc. Bead sorting on a droplet actuator
EP2837692A1 (en) 2007-03-22 2015-02-18 Advanced Liquid Logic, Inc. Enzymatic assays for a droplet actuator
US8093062B2 (en) 2007-03-22 2012-01-10 Theodore Winger Enzymatic assays using umbelliferone substrates with cyclodextrins in droplets in oil
WO2008118831A2 (en) 2007-03-23 2008-10-02 Advanced Liquid Logic, Inc. Droplet actuator loading and target concentration
JP2010524002A (ja) 2007-04-10 2010-07-15 アドヴァンスト リキッド ロジック インコーポレイテッド 液滴分配装置および方法
US20100206094A1 (en) 2007-04-23 2010-08-19 Advanced Liquid Logic, Inc. Device and Method for Sample Collection and Concentration
WO2008134153A1 (en) 2007-04-23 2008-11-06 Advanced Liquid Logic, Inc. Bead-based multiplexed analytical methods and instrumentation
US20100087012A1 (en) 2007-04-23 2010-04-08 Advanced Liquid Logic, Inc. Sample Collector and Processor
US8951732B2 (en) 2007-06-22 2015-02-10 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification in a temperature gradient
WO2009021173A1 (en) 2007-08-08 2009-02-12 Advanced Liquid Logic, Inc. Use of additives for enhancing droplet operations
US20100120130A1 (en) 2007-08-08 2010-05-13 Advanced Liquid Logic, Inc. Droplet Actuator with Droplet Retention Structures
WO2009021233A2 (en) 2007-08-09 2009-02-12 Advanced Liquid Logic, Inc. Pcb droplet actuator fabrication
BRPI0815698A2 (pt) 2007-08-24 2017-06-13 Advanced Liquid Logic Inc manipulação de contas em um atuador de gotículas.
WO2009032863A2 (en) 2007-09-04 2009-03-12 Advanced Liquid Logic, Inc. Droplet actuator with improved top substrate
US20100236928A1 (en) 2007-10-17 2010-09-23 Advanced Liquid Logic, Inc. Multiplexed Detection Schemes for a Droplet Actuator
US8460528B2 (en) 2007-10-17 2013-06-11 Advanced Liquid Logic Inc. Reagent storage and reconstitution for a droplet actuator
WO2009052354A2 (en) 2007-10-17 2009-04-23 Advanced Liquid Logic, Inc. Droplet actuator structures
US20100236929A1 (en) 2007-10-18 2010-09-23 Advanced Liquid Logic, Inc. Droplet Actuators, Systems and Methods
EP2220102B1 (en) 2007-11-06 2014-04-16 Clinical Micro Sensors, Inc. Baseless nucleotide analogues and uses thereof
WO2009076414A2 (en) 2007-12-10 2009-06-18 Advanced Liquid Logic, Inc. Droplet actuator configurations and methods
CA2709928A1 (en) 2007-12-23 2009-07-09 Advanced Liquid Logic, Inc. Droplet actuator configurations and methods of conducting droplet operations
US20110104725A1 (en) 2008-05-02 2011-05-05 Advanced Liquid Logic, Inc. Method of Effecting Coagulation in a Droplet
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
US20110097763A1 (en) 2008-05-13 2011-04-28 Advanced Liquid Logic, Inc. Thermal Cycling Method
ES2438989T3 (es) 2008-05-13 2014-01-21 Advanced Liquid Logic, Inc. Dispositivos, sistemas y métodos accionadores de gotitas
US20120261264A1 (en) 2008-07-18 2012-10-18 Advanced Liquid Logic, Inc. Droplet Operations Device
US8364315B2 (en) 2008-08-13 2013-01-29 Advanced Liquid Logic Inc. Methods, systems, and products for conducting droplet operations
CN102203605B (zh) * 2008-08-27 2014-07-23 生命技术公司 处理生物样品的设备和方法
WO2010077859A2 (en) 2008-12-15 2010-07-08 Advanced Liquid Logic, Inc. Nucleic acid amplification and sequencing on a droplet actuator
US8877512B2 (en) 2009-01-23 2014-11-04 Advanced Liquid Logic, Inc. Bubble formation techniques using physical or chemical features to retain a gas bubble within a droplet actuator
WO2010144747A2 (en) * 2009-06-10 2010-12-16 Cynvenio Biosystems, Inc. Flexible pouch and cartridge with fluidic circuits
US8926065B2 (en) 2009-08-14 2015-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
US8846414B2 (en) 2009-09-29 2014-09-30 Advanced Liquid Logic, Inc. Detection of cardiac markers on a droplet actuator
WO2011057197A2 (en) 2009-11-06 2011-05-12 Advanced Liquid Logic, Inc. Integrated droplet actuator for gel electrophoresis and molecular analysis
EP2516669B1 (en) 2009-12-21 2016-10-12 Advanced Liquid Logic, Inc. Enzyme assays on a droplet actuator
PL2539450T3 (pl) 2010-02-25 2016-08-31 Advanced Liquid Logic Inc Sposób wytwarzania bibliotek kwasu nukleinowego
EP2553473A4 (en) 2010-03-30 2016-08-10 Advanced Liquid Logic Inc DROPLET OPERATION PLATFORM
WO2012009320A2 (en) 2010-07-15 2012-01-19 Advanced Liquid Logic, Inc. Systems for and methods of promoting cell lysis in droplet actuators
WO2012084615A1 (de) * 2010-12-20 2012-06-28 Boehringer Ingelheim Microparts Gmbh Verfahren zum mischen wenigstens einer probenlösung mit wenigstens einem reagenz und vorrichtung
WO2012100078A1 (en) 2011-01-19 2012-07-26 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay
US8901043B2 (en) 2011-07-06 2014-12-02 Advanced Liquid Logic, Inc. Systems for and methods of hybrid pyrosequencing
US20130018611A1 (en) 2011-07-11 2013-01-17 Advanced Liquid Logic Inc Systems and Methods of Measuring Gap Height
US20130017544A1 (en) 2011-07-11 2013-01-17 Advanced Liquid Logic Inc High Resolution Melting Analysis on a Droplet Actuator
US8894946B2 (en) * 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US10132728B2 (en) * 2012-04-27 2018-11-20 Cepheid Apparatus with heterogeneous processing modules
US20130331298A1 (en) * 2012-06-06 2013-12-12 Great Basin Scientific Analyzer and disposable cartridge for molecular in vitro diagnostics
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP1628115S (https=) 2012-10-24 2019-04-01
US9995742B2 (en) * 2012-12-19 2018-06-12 Dnae Group Holdings Limited Sample entry
WO2014120998A1 (en) * 2013-01-31 2014-08-07 Luminex Corporation Fluid retention plates and analysis cartridges

Also Published As

Publication number Publication date
WO2016077364A3 (en) 2016-08-11
EP4578539A3 (en) 2025-10-01
WO2016077364A2 (en) 2016-05-19
ES3038141T3 (en) 2025-10-09
EP3831481B1 (en) 2025-06-18
EP4578539A2 (en) 2025-07-02
JP2018502309A (ja) 2018-01-25
EP3831481A1 (en) 2021-06-09
EP3218108B1 (en) 2020-09-02
EP3218108A2 (en) 2017-09-20

Similar Documents

Publication Publication Date Title
US10864522B2 (en) Processing cartridge and method for detecting a pathogen in a sample
EP3218109B1 (en) Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) Cartridge for performing assays in a closed sample preparation and reaction system
EP3218108B1 (en) Fluid sample processing cartridge and use thereof
US12000847B2 (en) Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US10495656B2 (en) Integrated multiplex target analysis
US20180223345A1 (en) Integrated multiplex target analysis
HK40043431A (en) Fluid sample processing cartridge
HK40043431B (en) Fluid sample processing cartridge
HK1239608A1 (en) Fluid sample processing cartridge and use thereof
HK1239608B (en) Fluid sample processing cartridge and use thereof
HK1239609B (en) Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
HK1239609A1 (en) Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
HK40012764B (en) Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
HK40012764A (en) Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application