AU2015231172A1 - 6-substituted estradiol derivatives for the treatment of Alzheimer's Disease - Google Patents

6-substituted estradiol derivatives for the treatment of Alzheimer's Disease Download PDF

Info

Publication number
AU2015231172A1
AU2015231172A1 AU2015231172A AU2015231172A AU2015231172A1 AU 2015231172 A1 AU2015231172 A1 AU 2015231172A1 AU 2015231172 A AU2015231172 A AU 2015231172A AU 2015231172 A AU2015231172 A AU 2015231172A AU 2015231172 A1 AU2015231172 A1 AU 2015231172A1
Authority
AU
Australia
Prior art keywords
methyl
cyclopenta
diol
phenanthrene
decahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2015231172A
Other languages
English (en)
Inventor
Steven H. Nye
James G. Yarger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endece LLC
Original Assignee
Endece LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endece LLC filed Critical Endece LLC
Publication of AU2015231172A1 publication Critical patent/AU2015231172A1/en
Priority to AU2018201003A priority Critical patent/AU2018201003A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2015231172A 2014-03-19 2015-03-19 6-substituted estradiol derivatives for the treatment of Alzheimer's Disease Abandoned AU2015231172A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018201003A AU2018201003A1 (en) 2014-03-19 2018-02-12 6-substituted estradiol derivatives for the treatment of alzheimer's disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461955578P 2014-03-19 2014-03-19
US61/955,578 2014-03-19
PCT/US2015/021538 WO2015143201A2 (en) 2014-03-19 2015-03-19 6-substituted estradiol derivatives for the treatment of alzheimer's disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018201003A Division AU2018201003A1 (en) 2014-03-19 2018-02-12 6-substituted estradiol derivatives for the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
AU2015231172A1 true AU2015231172A1 (en) 2016-09-08

Family

ID=54141046

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2015231172A Abandoned AU2015231172A1 (en) 2014-03-19 2015-03-19 6-substituted estradiol derivatives for the treatment of Alzheimer's Disease
AU2018201003A Abandoned AU2018201003A1 (en) 2014-03-19 2018-02-12 6-substituted estradiol derivatives for the treatment of alzheimer's disease

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2018201003A Abandoned AU2018201003A1 (en) 2014-03-19 2018-02-12 6-substituted estradiol derivatives for the treatment of alzheimer's disease

Country Status (11)

Country Link
US (1) US20150265630A1 (https=)
EP (1) EP3119402A4 (https=)
JP (1) JP2017512769A (https=)
KR (1) KR20160136363A (https=)
CN (1) CN106255501A (https=)
AU (2) AU2015231172A1 (https=)
BR (1) BR112016021408A2 (https=)
CA (1) CA2940536A1 (https=)
MX (1) MX2016012045A (https=)
SG (1) SG11201607693WA (https=)
WO (1) WO2015143201A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020247407A1 (en) * 2019-06-03 2020-12-10 Aihol Corporation Hyaluronan conjugates and uses thereof
US20210024568A1 (en) * 2019-07-23 2021-01-28 Endece Llc Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US20080200441A1 (en) * 2007-02-14 2008-08-21 University Of Southern California Estrogen receptor modulators associated pharmaceutical compositions and methods of use
CN106420767A (zh) * 2011-03-21 2017-02-22 安德斯有限责任公司 用于神经轴突的髓鞘再生的6‑取代的雌二醇衍生物

Also Published As

Publication number Publication date
CN106255501A (zh) 2016-12-21
JP2017512769A (ja) 2017-05-25
EP3119402A2 (en) 2017-01-25
SG11201607693WA (en) 2016-10-28
BR112016021408A2 (pt) 2017-12-19
KR20160136363A (ko) 2016-11-29
EP3119402A4 (en) 2017-11-01
CA2940536A1 (en) 2015-09-24
MX2016012045A (es) 2017-01-19
WO2015143201A2 (en) 2015-09-24
AU2018201003A1 (en) 2018-03-01
US20150265630A1 (en) 2015-09-24

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted