AU2014351796B2 - Preparations and methods for treating a GD2 positive cancer - Google Patents

Preparations and methods for treating a GD2 positive cancer Download PDF

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Publication number
AU2014351796B2
AU2014351796B2 AU2014351796A AU2014351796A AU2014351796B2 AU 2014351796 B2 AU2014351796 B2 AU 2014351796B2 AU 2014351796 A AU2014351796 A AU 2014351796A AU 2014351796 A AU2014351796 A AU 2014351796A AU 2014351796 B2 AU2014351796 B2 AU 2014351796B2
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Australia
Prior art keywords
treatment
antibody
patient
preparation
dose
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AU2014351796A
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English (en)
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AU2014351796A2 (en
AU2014351796A1 (en
Inventor
Isabel Klier
Ruth LADENSTEIN
Hans Loibner
Oliver MUTSCHLECHNER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apeiron Biologics GmbH
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Apeiron Biologics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP13193953.0A external-priority patent/EP2875827A1/en
Priority claimed from CA2834000A external-priority patent/CA2834000A1/en
Priority claimed from US14/182,776 external-priority patent/US10294305B2/en
Application filed by Apeiron Biologics GmbH filed Critical Apeiron Biologics GmbH
Publication of AU2014351796A1 publication Critical patent/AU2014351796A1/en
Publication of AU2014351796A2 publication Critical patent/AU2014351796A2/en
Application granted granted Critical
Publication of AU2014351796B2 publication Critical patent/AU2014351796B2/en
Priority to AU2020203346A priority Critical patent/AU2020203346A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3084—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AU2014351796A 2013-11-21 2014-11-21 Preparations and methods for treating a GD2 positive cancer Active AU2014351796B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2020203346A AU2020203346A1 (en) 2013-11-21 2020-05-22 Preparations And Methods For Treating A GD2 Positive Cancer

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201314086696A 2013-11-21 2013-11-21
EP13193953.0 2013-11-21
US14/086,696 2013-11-21
CA2834000 2013-11-21
EP13193953.0A EP2875827A1 (en) 2013-11-21 2013-11-21 Preparations and methods for treating a GD2 positive cancer
CA2834000A CA2834000A1 (en) 2013-11-21 2013-11-21 Method for treating a gd2 positive cancer
US14/182,776 US10294305B2 (en) 2012-06-18 2014-02-18 Method for treating a GD2 positive cancer
US14/182,776 2014-02-18
PCT/EP2014/075315 WO2015075194A1 (en) 2013-11-21 2014-11-21 Preparations and methods for treating a gd2 positive cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020203346A Division AU2020203346A1 (en) 2013-11-21 2020-05-22 Preparations And Methods For Treating A GD2 Positive Cancer

Publications (3)

Publication Number Publication Date
AU2014351796A1 AU2014351796A1 (en) 2016-05-26
AU2014351796A2 AU2014351796A2 (en) 2016-08-11
AU2014351796B2 true AU2014351796B2 (en) 2020-02-27

Family

ID=53179006

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014351796A Active AU2014351796B2 (en) 2013-11-21 2014-11-21 Preparations and methods for treating a GD2 positive cancer
AU2020203346A Abandoned AU2020203346A1 (en) 2013-11-21 2020-05-22 Preparations And Methods For Treating A GD2 Positive Cancer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2020203346A Abandoned AU2020203346A1 (en) 2013-11-21 2020-05-22 Preparations And Methods For Treating A GD2 Positive Cancer

Country Status (19)

Country Link
US (3) US10995147B2 (https=)
EP (2) EP3620173A1 (https=)
JP (2) JP6693873B2 (https=)
AU (2) AU2014351796B2 (https=)
CA (1) CA2930285A1 (https=)
CY (1) CY1122508T1 (https=)
DK (1) DK3071220T3 (https=)
EA (1) EA201691055A1 (https=)
ES (1) ES2768649T3 (https=)
HR (1) HRP20200128T1 (https=)
HU (1) HUE047920T2 (https=)
LT (1) LT3071220T (https=)
NZ (1) NZ720273A (https=)
PL (1) PL3071220T3 (https=)
PT (1) PT3071220T (https=)
RS (1) RS59817B1 (https=)
SI (1) SI3071220T1 (https=)
SM (1) SMT202000027T1 (https=)
WO (1) WO2015075194A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013189516A1 (en) 2012-06-18 2013-12-27 Apeiron Biologics Ag Method for treating a gd2 positive cancer
US9840566B2 (en) 2013-11-21 2017-12-12 Apeiron Biologics Ag Preparations and methods for treating a GD2 positive cancer
DK3071220T3 (da) * 2013-11-21 2020-02-10 Apeiron Biologics Ag Præparater til at behandle en gd2-positiv cancer
RU2663104C1 (ru) * 2017-07-13 2018-08-01 Общество с ограниченной ответственностью "Реал Таргет" Получение пегилированных фрагментов gd2-специфичных антител, индуцирующих прямую клеточную гибель gd2-позитивных опухолевых клеток, и их применение в терапии gd2-позитивных опухолей
EP3684818A2 (en) * 2017-09-21 2020-07-29 UMC Utrecht Holding B.V. Anti-gd2 antibody for the treatment of neuroblastoma
US20230295339A1 (en) * 2020-07-06 2023-09-21 Eusa Pharma (Uk) Limited Method for treating a gd2-positive cancer
WO2026053122A1 (en) * 2024-09-04 2026-03-12 Dana-Farber Cancer Institute, Inc. Methods of treating retinoid responsive cancers

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863713A (en) 1986-06-23 1989-09-05 The Board Of Trustees Of Leland Stanford Jr. Univ. Method and system for administering therapeutic and diagnostic agents
NZ526720A (en) 2000-12-28 2007-11-30 Altus Pharmaceuticals Inc Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies
US7455833B2 (en) 2002-07-15 2008-11-25 Board Of Regents, The University Of Texas System Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids
CN100432105C (zh) 2002-12-17 2008-11-12 默克专利有限公司 与gd2结合的小鼠14.18抗体的人源化抗体(h14.18)以及其与il-2的融合
PL1706428T3 (pl) 2004-01-22 2010-02-26 Merck Patent Gmbh Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza
BRPI0617688A2 (pt) 2005-10-21 2011-06-07 Hoffmann La Roche método para expressão recombinante de um polipeptìdeo
EP1916257A1 (en) * 2006-10-27 2008-04-30 Charite-Universitätsmedizin Berlin GD2 peptide mimotopes for anticancer vaccination
US8278065B2 (en) 2008-06-30 2012-10-02 Morphotek, Inc. Polynucleotides encoding anti-GD2 antibodies
DK3323830T3 (da) 2010-06-19 2023-09-25 Memorial Sloan Kettering Cancer Center Anti-gd2 antibodies
JP5623999B2 (ja) 2010-08-31 2014-11-12 パナソニック株式会社 電子装置
US10344050B2 (en) 2011-10-27 2019-07-09 Genmab A/S Production of heterodimeric proteins
WO2013189516A1 (en) 2012-06-18 2013-12-27 Apeiron Biologics Ag Method for treating a gd2 positive cancer
US9777068B2 (en) 2012-06-18 2017-10-03 Apeiron Biologics Ag Method for treating a GD2 positive cancer
US9840566B2 (en) 2013-11-21 2017-12-12 Apeiron Biologics Ag Preparations and methods for treating a GD2 positive cancer
DK3071220T3 (da) * 2013-11-21 2020-02-10 Apeiron Biologics Ag Præparater til at behandle en gd2-positiv cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUSHNER B H ET AL, JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, (2001-11-15), vol. 19, no. 22, ISSN 0732-183X, pages 4189 - 4194 *
MURRAY J L ET AL, JOURNAL OF CLINICAL ONCOLOGY, AMERICAN SOCIETY OF CLINICAL ONCOLOGY, US, (1994-01-01), vol. 12, no. 1, ISSN 0732-183X, pages 184 - 193 *
R. HANDGRETINGER ET AL, EUROPEAN JOURNAL OF CANCER, (1995-01-01), vol. 31, no. 2, doi:10.1016/0959-8049(94)00413-Y, ISSN 0959-8049, pages 261 - 267 *

Also Published As

Publication number Publication date
JP7139293B2 (ja) 2022-09-20
JP2019218359A (ja) 2019-12-26
DK3071220T3 (da) 2020-02-10
US11492412B2 (en) 2022-11-08
NZ720273A (en) 2022-02-25
AU2014351796A2 (en) 2016-08-11
PL3071220T3 (pl) 2020-05-18
LT3071220T (lt) 2020-02-25
HRP20200128T1 (hr) 2020-05-15
JP2016539122A (ja) 2016-12-15
ES2768649T3 (es) 2020-06-23
JP6693873B2 (ja) 2020-05-13
WO2015075194A1 (en) 2015-05-28
RS59817B1 (sr) 2020-02-28
SI3071220T1 (sl) 2020-03-31
US20210221909A1 (en) 2021-07-22
CA2930285A1 (en) 2015-05-28
US10995147B2 (en) 2021-05-04
AU2020203346A1 (en) 2020-06-11
EP3071220A1 (en) 2016-09-28
PT3071220T (pt) 2020-02-03
US20240158530A1 (en) 2024-05-16
SMT202000027T1 (it) 2020-03-13
EP3071220B1 (en) 2019-12-25
HK1223039A1 (en) 2017-07-21
US20200332021A1 (en) 2020-10-22
CY1122508T1 (el) 2021-05-05
EA201691055A1 (ru) 2016-11-30
EP3620173A1 (en) 2020-03-11
AU2014351796A1 (en) 2016-05-26
HUE047920T2 (hu) 2020-05-28

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 25 JUL 2016

FGA Letters patent sealed or granted (standard patent)
GD Licence registered

Name of requester: EUSA PHARMA (UK) LIMITED