AU2013367751A8 - Nasal influenza vaccine composition - Google Patents

Nasal influenza vaccine composition

Info

Publication number
AU2013367751A8
AU2013367751A8 AU2013367751A AU2013367751A AU2013367751A8 AU 2013367751 A8 AU2013367751 A8 AU 2013367751A8 AU 2013367751 A AU2013367751 A AU 2013367751A AU 2013367751 A AU2013367751 A AU 2013367751A AU 2013367751 A8 AU2013367751 A8 AU 2013367751A8
Authority
AU
Australia
Prior art keywords
vaccine composition
influenza vaccine
nasal influenza
nasal
adjuvant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU2013367751A
Other versions
AU2013367751A1 (en
AU2013367751B2 (en
Inventor
Akira AINAI
Hideki Hasegawa
Taizou Kamishita
Takashi Miyazaki
Tadaki SUZUKI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toko Yakuhin Kogyo KK
National Institute of Infectious Diseases
Original Assignee
Toko Yakuhin Kogyo KK
National Institute of Infectious Diseases
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toko Yakuhin Kogyo KK, National Institute of Infectious Diseases filed Critical Toko Yakuhin Kogyo KK
Publication of AU2013367751A1 publication Critical patent/AU2013367751A1/en
Publication of AU2013367751A8 publication Critical patent/AU2013367751A8/en
Application granted granted Critical
Publication of AU2013367751B2 publication Critical patent/AU2013367751B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a nasal mucosal spray delivery type influenza vaccine composition which is characterized in that the composition comprises a gel base including an influenza virus inactivated whole particle antigen and a carboxyvinyl polymer but does not comprise an adjuvant.
AU2013367751A 2012-12-28 2013-10-23 Nasal influenza vaccine composition Active AU2013367751B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012-287900 2012-12-28
JP2012287900 2012-12-28
PCT/JP2013/078721 WO2014103488A1 (en) 2012-12-28 2013-10-23 Nasal influenza vaccine composition

Publications (3)

Publication Number Publication Date
AU2013367751A1 AU2013367751A1 (en) 2015-07-09
AU2013367751A8 true AU2013367751A8 (en) 2015-08-27
AU2013367751B2 AU2013367751B2 (en) 2018-02-08

Family

ID=51020588

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013367751A Active AU2013367751B2 (en) 2012-12-28 2013-10-23 Nasal influenza vaccine composition

Country Status (27)

Country Link
US (2) US20160015800A1 (en)
EP (2) EP3566715A1 (en)
JP (1) JP6247639B2 (en)
KR (1) KR102071099B1 (en)
CN (2) CN104884086A (en)
AU (1) AU2013367751B2 (en)
BR (1) BR112015015523B1 (en)
CA (1) CA2894223C (en)
CY (1) CY1122372T1 (en)
DK (1) DK2939692T3 (en)
ES (1) ES2731899T3 (en)
HK (1) HK1209646A1 (en)
HU (1) HUE044434T2 (en)
IL (1) IL239284B (en)
LT (1) LT2939692T (en)
MX (1) MX371154B (en)
MY (1) MY173503A (en)
NZ (1) NZ708922A (en)
PH (1) PH12015501482B1 (en)
PL (1) PL2939692T3 (en)
PT (1) PT2939692T (en)
RU (1) RU2652296C2 (en)
SG (2) SG10201705190TA (en)
SI (1) SI2939692T1 (en)
TR (1) TR201910293T4 (en)
TW (1) TWI624280B (en)
WO (1) WO2014103488A1 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010114169A1 (en) * 2009-03-31 2010-10-07 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration
US9585920B2 (en) 2011-02-04 2017-03-07 Katherine Rose Kovarik Method and system for treating cancer cachexia
US9457077B2 (en) 2009-11-18 2016-10-04 Katherine Rose Kovarik Method and system for targeting the microbiome to promote health and treat allergic and inflammatory diseases
US9408880B2 (en) 2013-12-20 2016-08-09 Katherine Rose Kovarik Method and system for prevention and treatment of allergic and inflammatory diseases
US11951139B2 (en) 2015-11-30 2024-04-09 Seed Health, Inc. Method and system for reducing the likelihood of osteoporosis
US11844720B2 (en) 2011-02-04 2023-12-19 Seed Health, Inc. Method and system to reduce the likelihood of dental caries and halitosis
US10314865B2 (en) 2011-02-04 2019-06-11 Katherine Rose Kovarik Method and system for treating cancer and other age-related diseases by extending the healthspan of a human
US9730967B2 (en) 2011-02-04 2017-08-15 Katherine Rose Kovarik Method and system for treating cancer cachexia
US12279989B2 (en) 2011-02-04 2025-04-22 Seed Health, Inc. Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity
US11951140B2 (en) 2011-02-04 2024-04-09 Seed Health, Inc. Modulation of an individual's gut microbiome to address osteoporosis and bone disease
US11998479B2 (en) 2011-02-04 2024-06-04 Seed Health, Inc. Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure
US12257272B2 (en) 2015-12-24 2025-03-25 Seed Health, Inc. Method and system for reducing the likelihood of developing depression in an individual
US11839632B2 (en) 2013-12-20 2023-12-12 Seed Health, Inc. Topical application of CRISPR-modified bacteria to treat acne vulgaris
US12329783B2 (en) 2013-12-20 2025-06-17 Seed Health, Inc. Method and system to improve the health of a person's skin microbiome
US12005085B2 (en) 2013-12-20 2024-06-11 Seed Health, Inc. Probiotic method and composition for maintaining a healthy vaginal microbiome
US11998574B2 (en) 2013-12-20 2024-06-04 Seed Health, Inc. Method and system for modulating an individual's skin microbiome
US11833177B2 (en) 2013-12-20 2023-12-05 Seed Health, Inc. Probiotic to enhance an individual's skin microbiome
US11826388B2 (en) 2013-12-20 2023-11-28 Seed Health, Inc. Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation
US12246043B2 (en) 2013-12-20 2025-03-11 Seed Health, Inc. Topical application to treat acne vulgaris
US11980643B2 (en) 2013-12-20 2024-05-14 Seed Health, Inc. Method and system to modify an individual's gut-brain axis to provide neurocognitive protection
US11969445B2 (en) 2013-12-20 2024-04-30 Seed Health, Inc. Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH
CA2951982A1 (en) * 2014-06-25 2015-12-30 Toko Yakuhin Kogyo Kabushiki Kaisha Rhinovaccination system of influenza vaccine
JP6322844B2 (en) 2014-06-25 2018-05-16 東興薬品工業株式会社 Nasal spray nozzle used for medical syringes
CN105342982B (en) * 2015-11-19 2018-08-28 上海现代药物制剂工程研究中心有限公司 Influenza vaccines immune formulation of nose administration and preparation method thereof
JP6916113B2 (en) * 2015-11-27 2021-08-11 日東電工株式会社 Method for Producing Vaccine Pharmaceutical Composition for Oral Administration and Vaccine Pharmaceutical Composition for Oral Administration
KR101944953B1 (en) * 2016-07-29 2019-02-01 메타볼랩(주) Antiviral composition against influenza virus for mucous membranes
EP3693006A4 (en) * 2017-10-05 2021-07-07 Toko Yakuhin Kogyo Co., Ltd. NASAL HEPATITIS B VACCINE COMPOSITION AND METHOD OF MANUFACTURING IT
WO2021002355A1 (en) 2019-07-03 2021-01-07 アイリス株式会社 Pharmaceutical composition for treating influenza virus infections
CN113117093B (en) * 2019-12-31 2024-02-09 辽宁成大生物股份有限公司 Promoter suitable for nasal mucosa delivery of influenza vaccine
AU2022401207A1 (en) 2021-12-02 2024-06-06 Toko Yakuhin Kogyo Co., Ltd. Nasal vaccine-spraying formulation for simultaneously targeting nasal mucosa and nasopharynx
AU2022423668A1 (en) * 2021-12-20 2024-07-11 Japan As Represented By Director General Of National Institute Of Infectious Diseases Vaccine adjuvant agent containing polyacrylic acid polymer and use of same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158761A (en) * 1989-04-05 1992-10-27 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
US5215739A (en) * 1989-04-05 1993-06-01 Toko Yakuhin Kogyo Kabushiki Kaisha Spray gel base and spray gel preparation using thereof
JPH0678245B2 (en) * 1989-07-04 1994-10-05 東興薬品工業株式会社 Influenza vaccine gel formulation for nasal spray administration
KR20070116650A (en) * 2005-03-23 2007-12-10 글락소스미스클라인 바이오로지칼즈 에스.에이. Composition
AU2007241829B2 (en) 2006-04-21 2012-11-29 Shinko Chemical Co., Ltd. Fluid container and airless fluid dispensing system
MX2008013542A (en) * 2006-04-21 2008-10-31 Toko Yakuhin Kogyo Kk Sprayable gel-type skin/mucosa-adhesive preparation and administration system using the preparation.
WO2010114169A1 (en) * 2009-03-31 2010-10-07 Japan As Represented By The Director-General Of National Institute Of Infectious Diseases Method for prophylaxis of influenza using vaccine for intranasal administration

Also Published As

Publication number Publication date
LT2939692T (en) 2019-08-12
CA2894223C (en) 2021-04-06
HK1209646A1 (en) 2016-04-08
JPWO2014103488A1 (en) 2017-01-12
PL2939692T3 (en) 2019-10-31
PH12015501482A1 (en) 2015-09-21
PT2939692T (en) 2019-06-27
EP2939692A4 (en) 2016-07-06
CN110038123A (en) 2019-07-23
SI2939692T1 (en) 2019-10-30
MX371154B (en) 2020-01-20
BR112015015523A2 (en) 2017-07-11
RU2015130634A (en) 2017-02-01
IL239284A0 (en) 2015-07-30
RU2652296C2 (en) 2018-04-25
TR201910293T4 (en) 2019-07-22
EP3566715A1 (en) 2019-11-13
TWI624280B (en) 2018-05-21
HUE044434T2 (en) 2019-10-28
BR112015015523B1 (en) 2023-02-23
CA2894223A1 (en) 2014-07-03
EP2939692A1 (en) 2015-11-04
CN104884086A (en) 2015-09-02
TW201427724A (en) 2014-07-16
EP2939692B1 (en) 2019-04-24
ES2731899T3 (en) 2019-11-19
PH12015501482B1 (en) 2015-09-21
JP6247639B2 (en) 2017-12-13
AU2013367751A1 (en) 2015-07-09
KR102071099B1 (en) 2020-01-29
MX2015008380A (en) 2016-03-15
MY173503A (en) 2020-01-29
SG10201705190TA (en) 2017-07-28
CY1122372T1 (en) 2021-01-27
IL239284B (en) 2020-02-27
KR20150102995A (en) 2015-09-09
US20160015800A1 (en) 2016-01-21
AU2013367751B2 (en) 2018-02-08
NZ708922A (en) 2019-10-25
WO2014103488A1 (en) 2014-07-03
US20190091324A1 (en) 2019-03-28
DK2939692T3 (en) 2019-07-08
SG11201504648TA (en) 2015-07-30

Similar Documents

Publication Publication Date Title
AU2013367751A8 (en) Nasal influenza vaccine composition
WO2012024621A3 (en) Synthetic nanocarrier vaccines comprising peptides obtained or derived from human influenza a virus hemagglutinin
MX2021001053A (en) Influenza virus vaccines and uses thereof.
EP4218807A3 (en) Zika virus vaccine
WO2011103453A3 (en) Vaccines for use in the prophylaxis and treatment of influenza virus disease
MX2015008847A (en) Influenza virus immunogenic compositions and uses thereof.
MX346625B (en) Influenza virus mutants and uses therefor.
MX2014003308A (en) Influenza virus vaccines and uses thereof.
AU2011280259A8 (en) Influenza vaccine
WO2012027365A3 (en) Targeted multi-epitope dosage forms for induction of an immune response to antigens
PH12013502442A1 (en) Inactivated dengue virus vaccine
EA201590860A1 (en) VARIANTS OF HEMAGGLUTININ AND NEURAMINIDASE OF THE SWIN SWIRUS VIRUS
BR112015012841A2 (en) immunogenic composition, vaccine, and use of an immunogenic composition
MX2015007753A (en) Vaccine composition for naive subjects.
WO2014145932A3 (en) Specific multivalent virus-like particle vaccines and uses thereof
PH12019501569A1 (en) Universal influenza vaccine compositions
AR088220A1 (en) ACTIVATION OF HUMAN DENDRITIC CELLS BY THE DECTIN-1 OR TOLL 2 (TLR2) RECEPTOR IN THE CONTROL OF ALLERGY AND ASTHMA
BR112012022939A2 (en) pharmaceutical composition for use in a method of immunizing an individual in need thereof against an influenza virus
FI20115374A0 (en) New hypoallergens
CY1123453T1 (en) RNA PREPARATION FOR IMMUNOTHERAPY
NZ727360A (en) Rhinovaccination system of influenza vaccine
EP3599247A3 (en) Recombinant hemagglutinin protein of influenza virus and vaccine containing the same
MX2016002823A (en) Methods and compositions for viral vectored vaccines.
WO2011138032A3 (en) Universal influenza vaccines and methods for their generation
MX2019007924A (en) Influenza vaccines.

Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 29 , NO 26 , PAGE(S) 3887 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME TOKO YAKUHIN KOGYO KABUSHIKI KAISHA; JAPAN AS REPRESENTED BY DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES, APPLICATION NO. 2013367751, UNDER INID (72) CORRECT THE CO-INVENTOR TO KAMISHITA, TAIZOU

FGA Letters patent sealed or granted (standard patent)