WO 2013/140380 PCT/IB2013/052303 AUTO-DiSABRLt SYRINGE ASSEMBi 4 BACKGROUND OF THE INVENTION [0001] The Field of the Invention: The present invention relates to devices adapted to control motion of fluid. In particular, preferred embodiments are adapted to pennit riultiple falling and emptying cycles with a single syringe, but then automatically disable that syringe to resist syringe reuse subsequent to a final dose-jecting cycle [0002] Related Art: Syringes adapted to permit only a single use are known. Desirably, after a single use, such a syringeawill automatically be rendered inoperable. Such auto disable syringes are desirable, for example, to reduce spread of blood-bome disease between individuals who share a common needle. (0003] A plurality of differently structured syringes have been developed to address the desire for an effective autodisabie syringe, A problem with many commercially available syringes is that they do not permit use of a single syringe to permit multiple filling and complete emptying cycles, but then automatically disable that syringe to resist syringe reuse subsequent to a final dose-jecting cycle. There is a need for a syringe that can be coupled to a needle to inspire fluid into the syringe, then expel that fluid into a container to reconstitute a treatment substance After the treatment substance is reconstituted, it is desirable to refl the same syringe with one or more dose of treatment substance, It is further desirable for the syringe to then auito-isable upon dispensing the entire contents of the syringe. Sometimes, it is desirable to detach a needle used to inspire fluids into the syringe and to attach a different fluid-guiding element to the syringe before dispensing the fluid contents of the syringe in an auto-disable cycle. [0004] As a practical matter, a syringe should first be completely emptied before inspiring one or more dose of reconstituted treatment substance, to avoid dilution of the treatment substance to an unknown and variable degree. It is not feasible to substantially empty certain connercially available auto-disable syringes without risk of accidentally engaging their auo-disable feature, consequently requiring use of a different syringe to administer the treatment substance. [0005] In United States patent application No: 2010/0030146, Kakish et A disclose an auto-disable device for syringes that permits a user to fill the syringe by inspiring fluid through a needle, and automaically disable that syringe upun discharge of the syringe contents, Their 1 WO 2013/140380 PCT/IB2013/052303 device's needle is not removable after being coup-led to the syringe body, and consequently, their syringe assembly cannot realistically be used to reconstitute a treatment substance and subsequently dispense a portion of that treatment substance with the same syringe. Once flild begins to be expelled from their syrnge, an internal mechanism is displaced to prevent fluid fIrom being inspired into the syinge, Therefore, refilling the same syringe is precluded. [0006] In United States patent No. 6,752,784, Tsai discloses a safety syringe of the type in which capture smiucture carried on a plunger is coupled with koking structure to maintain a blocking element inside the syrnge discharge aperture. The plunger inevitably couples with capture structure upon complete discharge of fluid contents fin the syringe. Reuse of the syringe is consequently resisted subsequent to complete" discharge of the syringe, In fact, attempting to retreat hiS plunger from a fully-expelled position causes the distal portion of the syringe barrel to retract into his syringe body, which can serve as a safety cover for a needle assembly. Similar devices are disclosed in United States patent application No, 2006/0084915 to Chang, and United States patent application No. 2009/0247948 to Walsh et al [0007] A commercially available auto-disable syringe includes a iml Auto Disable Syringe, available from Zhejiang Yusheng Medical Instrument Cotd, having a place of business in Xuanmen Industry Zone, Yuhuan City sZhqjiang,China, and a world wide web address of ziyasheng. com. Such syringe includes a plunger having distally disposed capture structure on a shaft that couples with locking structure in the syringe discharge .uer effective to resist retraction of the phnger from a fluid fully--expelled position If a user retracts the plunger stemn with sufficient force, a pmximal portion of the plunger stem is structured to break off and separate leaving behind a stopper that is essentially pinned inside the discharge aperture of the syringe, thereby resisting reuse of the syringe. BREF SUMMARY [0008] The invention may be embodied to provide an apparatus and a method of use of that appamatus A currently preferred apparatus forms an assembly including a. syringe body tending foim an open proximal end to a discharge aperture at a distal end. A plunger assembly is disposed for reciprocal motion inside the body between a dose-loaded position and a dose fuly expelled posAi distal end of the plunger assembly carries capture structure configured to protrude distally, by an operable distance, from the syringe discharge apeture when the plunger 2 WO 2013/140380 PCT/IB2013/052303 assembly is disposed at the fid ly-expeled position. [0009] 'he aforementioned assembly also includes a first locking element that is separate and discrete fi the syringe body and is disposable at a position distal to the distal end of the syringe body. The first locking elem entis configured and arranged to couple with capture structure, when the plunger is displaced distally to the fully-expelled position, effective to resist reuse of the syringe. In most cases, a first locking element is afixed to an end-use fluid dispensing or fluid-acquiring attachment that can be coupled to the syringe discharge aperture to permit one final ejection of fluid through the attachment by operation of the plunger The first locking element can be an integral part of a fluid-guiding device, such as a fluid-dispensing or fluid-acquiring attachment, or may be temporarily, or permanently, coupled to the attachment A first locking element may also be embodied as a separate, stand-alone component. [0010] A currently preferred first locking element is structured to effect a press-fit engagement, or friction coupling, with a fluid-guiding device. In such an arrangement attempting to disengage a fluid-guiding device from a syringe body (eg, by unscrewing a conventional luer locking joint) subsequent to effecting a captured plunger coupling with a locking element will simply disengage the first locking element front its press-fit engagement with the fluid-guiding device. The disengaged Arst locking element remains coupled to the capture structure and the syringe is disabled to resist plunger reciproation and syringe reuse, Essentialy, the press-fit coupling desirably forms a weakestt link" to prevent the plunger from breaking at a location that would permit reuse of the syringe. [0011] An operable plunger assembly may sometimes include decoupling structure configured to permit separation of a proximal stem end of the plunger assembly fm the distal end of the plunger assembly responsive to a user attempting to proximally displace the plunger assembly from a captured configuration comprising the fully-expelled position. An exemplary decoupling structure includes a pull-apart joint disposed at an intennediate location of the plunger assembly. One operable pull-apart joint includes a first interfhce structured to fail, or otherwise separate, in shear under a lower stemn tension load than required for a critical cross-section of capture structure to fail under tension. The currently preferred pull-apart joint includes a one-way pull-apart joint with mutually cooperating surfaces of the plunger assembly being stmutured to bear in compression as the plunger i. displaced from a dose-loaded position toward the dose fully expelled position. 3 WO 2013/140380 PCT/IB2013/052303 [00121 Typically, a distal end of the syringe body carries a first length of hollow male I er-locking taper terminaing at a distal interface. In such case, a proximal end of a first locking element may be configured and warrged to cause a structural interference with the distal interface effective to resist proxiimal displacement of capture structure carried by the plunger, Sometimes a first locking element may be structured as a second length of hollow male luer-locking taper sized as an operable extension of the first length. [0013] One operable capture structure includes a proximally facing surface. Upon coupling with the capture structure, rocking structure of a cooperating first locking eren is then configured and arranged to cause a strucmral interference with the proximally facing surface. An operable first loMking structure can include a selfbiased finger. Similarly, locking structure of a first locking element can include a plurality of self-biased fingers that are displaceable by proximal movement of capture structure to fonn a friction contact interface between the fingers and capture structure. [0014] Sometimes, certain embodiments of the invention may include a second looking element strutured to resist removal of an end-use fluid-dispensing device from captured engagement with a syringe. An operable second locking element includes structure carried by the end-use flid-dispensing device which automatically engages with, and creates a structural interference with, a female thread of a luer-lock device to resist rotation of the end-use flaid dispensing de-vice in a disassembling direction. [0015] A method of use of a preferred apparatus includes providing an auto-disable syringe having a planger disposed for reciprocation in a body effective to inspire and eject fluid. A user may couple a fluid-guiding or -inspiring attaciment (e'g a needle) to the syringe, or use the syringe a stand-alone device to inspire a dose of fluid into the syringe, After a dose of fluid is inspired into the syringe, the user may then inject at least a portion of the dose of fuid into a container effective to reconstitute a treatment substance A needle can be coupled to the syringe discharge orifice to facilitate guiding discharged fluid into a container, such as a vial. Typically, the User will displace the plunger to a fluid fully-expelled position in preparation for loading one or more dose of threaten substance into the syringe, The user may then inspire a portion of the treatment substance into the syringe. Finally, the user wiJ distally spacee the plunger t) the fluid fully-expelled position to expel a final dose of treatment substance while simultaneously coupling a -fIrst king element to the plunger efTective to resist retraction of the plunger from the 4 WO 2013/140380 PCT/IB2013/052303 fulhy-expelled position. (0016] After inspiring a portion of treatment substance into the syringe, the user may remove the fluidinspiring device and couple a second, and different, Iluid-dispensing device to the syringe, The second fluid dispensing device may sometimes be made reference to as an end use device. In that case, the second fluid-dispensing device typically cares the first locking element, which is structured to couple with capture structure carried by the plunger. Conventionally, capture structure is configured to protrude distally from a discharge aperture of the syringe when the plunger is disposed at the fluid fiully-expelled position, Sometimes, subsequent to coupling the first locking element to the plunger, a user may proximally retract a stem portion of the phnger effective to separate the stem portion from a distal portion of the plunger, Sometimes, assembling the second fluid-dispensing device to a lter-lock device carried by the syringe automatically engages a second locking element efietive to resist removal of the second fluid-dispensing device from the syringe. BIEF DESCRIPTION OF THE DRAWINGS [0017) In the drawings, which illustrate what are currently regarded as the best modes for carrying out the invention, and in which sinilar components are generally designated with simar numerahs: [0018] FIG, I is an exploded assembly plan view, to scale, of a currently preferred embodiment that is constructed according to certain principles ofthe instant invention; [0019] FIG. 2 is a side view, partially in section, of a portion of the phuger illustrated inl 1G .1; [0020] FIG, 3 is a side view, partially hi section, of a portion of the plmger illustrated in FIG 2, at further state of assembly; [0021] FIG. 4 is a side view in elevation of a portion of the embodiment illustrated in FIG. 1, at a dose-loaded position; (0022] FIG, 5 is a side view in elevation of the embodiment in FIG, 4, but at a fully expelled position; [0023] FIG. 6 is a sa view in elevation of the embodiment in FIG, 4, but in a frustrated-reuse position; [0024) FIG, 7 is a side view in elevation of an embodiment structured according to 5 WO 2013/140380 PCT/IB2013/052303 certain principles of the invention, in combination with a plurality of operable attachments, partially exploded; [0025] FIG. 8 is a close-up side view in elevation and cross-section of a portion of a crrently preferred embodiment that is constructed according to certain principles of the instant invention, at a dose-expelled and captured position; [00261 FIG. 9 is a close-up side view in elevation and partial cross-section of a portion of an altematve embodiment that is constructed according to certain principles of the instant invention, at a faily-expelled position; [002?] FIG. 10 is a close-up side view in elevation and partial cross-section of the embodiment in FIG. 9, but at a fullyexpeed and captured position; [0028] FIG, II is a perspective cross-section view looking at the proximal end of a currently preferred first locking element; [0029] FI3. 12 is a view in perspective of a currently preferred second locking element; [0030] FIG 13 is a proximal end view of the embodiment in FIG. 12; [0031] FIG. 14 is a side view of the embodiment in FIG. 12: [0032] FIG. !5 is a distal end view of the embodiment in FIG. 12; (0033] FIG, 16 is a side view of the embodiment in FIG, 15, looking in the direction of arrows at section 16-16; [0034] FIG, 17 is a view in perspective of the emibodimenti in FIG 12 installed on a conduit; [0035] FIG. 18 is a side view in cross-section of the embodiment in FI. 17, also coupled to an atomizer and installed on a luer-lock end of a syringe; [0036] FIG, 19 is a view in perspective of an atemative second locking element installed in registration on a conduit; [0037) FIG 20 is an exploded assembly view of the embodiment in FIG, 19; [0038] FIG, 21 is a side view in cross-section of the embodimnent in FIG 20, taken at section 21~21; [0039] FIG. 22 is an exploded assembly view in perspective of the embodiment in FIG. 19; (0040] FIG,. 23 is a distal end view of the embodiment in FIG. 19, taken from secdon 6 WO 2013/140380 PCT/IB2013/052303 2323 in FIG. 21, and looking in the direction of the arrows; {0041] FIG. 24 is a proximal end view ofthe second locking element in FIG. 19; and [0W42] FIG, 25 is a plan view of a fat sheet patten that can be used to make the second lockmg element in FIG. 19, DETAILED DESCRIPTION OF THE XLLUSTRATED EMBODIMENTS [0043] The present invention may be embodied to provide an automatically-disabled syringe assembly. At least certain embodiments permit a syringe to experience multiple filling and emuplying cycles before the syringe is disabled subsequent to a final discharge cycle, typically using an end-use fluid-guiding device. [0044] As illustrated in FIG, I, one edrrenly preferred embodhuent is an assembly of a plurality of Clements generally indicated at 100. Assembly 100 inc ludes a syringe body 102 having an open proximal end, generally 104, and a distal end, generaly 106. A syringe body 102 can be as large in fluid capacity as is desired. Syringe body 102 is illustrated in FIG. I as being substantially transparent. Of course, such is not required, and syinges having one or more partialy opaque, or fully opaque, areas of constnc tion are workable. [0045] Distal end 106 of illustrated syringe body 12 carries iuer-locking structure including a length of hollow nale aerdocking tapered element 108, and a threaded female socket 110. The hollow portion of lur-locking clement 108 forms a discharge orifice for the syringe body 102. Fluid-guiding attachments may be coupled in fluid-tight engagement with luer-locking element 108 in substantially conventional fashion; i the illustrated embodiment, internally threaded socket 110 is integrated into syringe body 102, firming a contiguous stmcture, In other workable embodiments, a soket I10 may be adapted to rotate with respect to the syringe body. [0046] Although at least a short length of luer-locking taper 108 is highly desirable, altermatixe configurations are workable, including an extemally-threaded hollow male discharge end (not illustrated), While the embodiment illustated in FIG. I is based on the ubiquitous 6% conical taper luer-locking Joint, principles of the invention apply to alternative structures, including alternative sizes of conventional luer-locking devices. The standard for 6% conical taper joints is set forth in ISO 594,2 Standard, "Conical Fittings with a 6% (bier taper for syringes, needles and certain other medical equipment - Part 2: Lock fittings" 'The coupling conventionally present in an oral syringe (which is larger than tl 6% luer-locking joint), is 7 WO 2013/140380 PCT/IB2013/052303 another alternative workable connector. A workable distal coupling structure of an alternative syrige body simply helps to form a fluid leakresistant connection to a desired fluid-guiding attachnent device for fluid dispensing or flid acquisition. {0047] Still with reference to FIG 1, assembly 100 also includes a plunger assembly, generally indicated at 120. Illustrated plunger assembly includes sten 122, core element, generally indicated at 24 and wiper element 126, Wiper element 1.26 is structuired to be maintained in registradon on core 124 and forms a fluid-tight seal for reciprocation inside body 102 to inspire and expel fluid from the assembly 100 (see also FIGs. 2 and 3), It is currently preferred; although not required, for core element 124 to be detachable Brom the stem 122. It should also be noted that ahematively structured sterns may be used For examples, the stem may ahtematively include a thumb hole, or handle, to permit a user's thumb or hand, respectively, to reciprocate the sterm 10048] As seen in F Is. 2 and 3, a workable core 124 includes an elongate shaft 128 having an axial length in excess of L and structured to dispose capture structure, generally indicated at 30 distal to the discharge aperture of a syringe body 102 when the plunger 120 is disposed at a fluid dose finly-expelled position. Capture suture 130 ilustrated in FiGs 2 and 3 includes a proximally facing surface, indicated generally at 132. By "proximally facing surface" it is intended to encompass suriaces having a normal vector with a component directed in the proximal direction. In pardcuar, the normal vector of a "proximally facing surface" is not required to be substantially parallel with a length axis of the core 124,as illustrated. [0049] In certain enibdiments, and as illustrated, a size and shape (eig. diameter) of shaft 128 is desirably formed in rlatively close agreement with the syringe discharge aperture (e,g. bore in hollow luer element 108) to reduce "dead space' and promote complete evacuation of the syringe's contents. While shaft 128 can typically reciprocate through the discharge apertre of syringe, body 102 without interference, Ahoulder 134 of the illustrated embodiment forms a strctural interference with body 102 when the plunger 120 is located at a fluid fdly~ expelled position. Shoulder 134 is an exemplary stopper element that resists travel of the core in a distal direction. In some cases, a wiper element, such as 126, can also fmetion as a stopper, [00150] For purpose of this disclosure, a locking element is effective to resist disassembly of iwo or more componenms of an assembly. With reference again to FIG. I, assembly 100 further includes a first Jock ing element, generally 140, and an (optional) fluid 8 WO 2013/140380 PCT/IB2013/052303 dispensig or fluid-acquiring attachment, generally 142. A workable attanchent 142 may include a fluid atomizer 144, although other conventional fluid-guiding structures or devices such as needles, tubing connctors, et.. are workable. [0053 Principles of operation of an exemplary device srctured according to certain principles of the invention are illustrated in FIGs, 4 through 6. In FIG, 4, steMn 122 is being displaced in a distal direction from a dose-loaded position, as indicated by arrow 150, indicating that the plunger is being depressed and is moving in a fluid-expelling direction [0052] With particular reference to FIG. 4, an exemplary first locking element 140, which is a separate and distinct element ficon the syringe body 102, is disposed in registration at the distal end of the luer element 108. As illustrated, an exerplary firsi locking element 140 may be embodied essentially as a second length of hollow male lcr-locking taper sized as an operable extension of a first length provided by luer-locking element 108. [0053] A distal end of hollow male luer-locking taper 108 terminates at a distal interface, indicated generally at 151 in FIG. 1, that is illustrated as being disposed at about the plane of the distal end of socket 110. A proximal end of first locking elment 140 includes a surface that is configured and arranged to cause a structural interference with the distal interfae 151 effective to resist proximal displacement (frorn a captured position) of shaft 128 and capture structure 130. [0054) FIG, 5 illustrates the plunger assembly 120 disposed a the fluid fidly-expelled and captured position, Effectively, the discharge aperture of the syringe body 102 is pinned between an internally disposed stopper, such as shoulder 134, and an external capture structure, such as first locking element 140, Consequently, the plunger cannot reciprocate, and the syringe assembly is effectively rendered incapable of reuse, Note that exemplary capture stmcture 130 is engaged by cantilevered fingers 152 of exemplary first picking element 140. If first locking element 140 was not present, the capture structure 130 and distal end of shaft 128 would simply protrude from the discharge aperture at the distal end of luer element 108, and the phnger assembly 120 would be free to reciprocate, [005] It is desirable for capture structure to engage wit locking Atruture without comamn using sability of the syringe assembly. That is, with rference to Fifs. 4 and 5, it is preferred for the shaft 128 to engage with locking element 140 wnhout requiring a user to exert an undue force on -the stem 122, In certain cases, a user will be substantially unaware as the lock-up 9 WO 2013/140380 PCT/IB2013/052303 occurs, [0056] FIG. 6 ilustrates optional decoupling structure, generally indicated at 154, configured to permit separation of a distal end of plunger sten 122 from a proximal end of core element 124 responsive to a user attempting to displace the plunger assembly from. a captured configuration (and in the proximal direction indicated by arrow 156). If a user were to retract the plunger stem 122 with sufficient force, decoupling stucture 154 would permit stem 122 to separate from core 124. Core 124 consequently remains behind, and blocks the discharge aperture of the syringe, thereby efeetively frustrating reuse of the syringe body 102, [0057] FIG. 7 illustrates a syrnge, generally indicated at 160, tat may be used in accordance with certain principles of the invention with a selected fluid guiding attachment. A nonim-hiting selection of fluid-guiding attachments are illustrated in FIG 7 For example, a needle, generally indicated at 162, may be affixed to the distal end of syringe 160 to inspire fluid into the syTinge. Then, the syringe 160 and needle 162 may be used to inject that inspired fluid into a container, e.g, to reconsitute a treatment substance, Needle 162 lacks a first locking element 140, so that syringe and needle combination can be reused a plurality of times. However, illustrated needle assembly 164 includes a first locking element 140 that is effective to resist proximal displacemdent of the plunger from a fluid fully-expelled position, [00581 Similarly, syringe 160 may be reused a plurality of times with the atomizer generally indicated at 16. No structure is present in that illustrated combination effective to resist retraction of the plunger of syringe 160 fmom a fluid fully-expelled position, In contrast, the atomizer assembly indicated at 170 includes a first locking element 140 that is ef&ctive to resist proximal displacement of the plunger front a fluid fluly-expelled position. Conuscquently, once the plunger of syringe 160 is captured i engagement with atomizer assembly 170, the syringe is effectively and automatically rendered incapable of reuse. [0059] Sometimes, a first locking assembly 140 is held in registration inside a fluid guiding attachment such as a needle assembly 164, or atomizer assembly 170 by way of a frictioa-fit, or press-fit. In certain other cases, a first locking element 140 can be a constituent part of, or permanently adhered to, or welded to, or otherwise affixed to, tue fluid-guiding attachment, It is within coantemplation that a locking element may even be positioned by alteMative stmcture, such as a users hand, to permit engagement of locking strmture associated with the locking element with capture structure of a plunger. 10 WO 2013/140380 PCT/IB2013/052303 [0060) With reference now to FIG. 8, an exemplary assembly 100 is illustrated in a fluid fly-expflled and shaft-captured position, It can clearly be seen that exemplary first locking element 140, which is separate and discrete from synge body 102, is disposable at a postin. distal to the syringe body Exemplary first looking element 140 may sometimes be characterized as an operable extension of male lureloclidn element 108 in that one operable embodiment of a first rocking element 140 may be formed substantially as an extension of the male tapered luer-locking surface of her element 108, Typically, locking element 140 is installed at a distay-spaced-apart opemble location inside fluid-guiding structure, such as atonizer 144, io permit fluid-tight engagement of the outside luer-locking surface of mae luer element 108 with the inside of the female luer element 174 before causing a stmetural interference between proximal. structre of first locking element 140 and a distal interfice 151 of haer element 108, Further, illustrated exemplary capture structure 130 is configured and arranged to couple with one or more cantilevered locking finger 152 caried at the proximal end of locking element 140, when stem 122 of the plhnger assembly is displaced distally to the iMiustraed fully-expelled positon, ce coupling is effective to resist retraction of the core 124, and frustite reuse of the syringe assembly 100, In the event that a user pls proximally on stem 122 with sufficient force, decoupling joint 154 would permit the stem 122 to separate flon the core 124, and further frustrate reuse of the syringe assembly 100. [AO61) An alternative workable embodiment of an auto-disable syringe assembly structued according to certain principles of the invention is illustrated in FIGs 9 and 10, and is generally indicated at 180, The extended shaft 128' of assembly 180 is structured to essentially maxinize expulsion of fluid from syringe body 102 and locking eemeat 182, Such complete expulsion of fhid reduces waste of expensive treatment compounds. [0062] It can be seen in FIG. 9 that exemplary extended shaft 128' protrudes distaly fron syringe body 102 by an operable distance L, when at the illustrated fluid fully-expelled position. By "operable distance" it is intended to mean that the protruding length L7 is sufficient to permit application of an operable retaining force to the exposed portion of the shaft 128, Known syringes adapted for such complete fluid expulsion (e~g zerc dead-space syringes) do not protrude a sufficient protruding le ngth (if a protruding length is provided at all) to permit the required ahaft loading. [O&31 A "retaining fbrce" is defined, for purpose of this document, as resisting a user 11 WO 2013/140380 PCT/IB2013/052303 from pulling by hand on a stem 122 to retract the core element 124 from an entrapped position, such as illustrated in FIGs. 8 and M0I An exemplary "retaining force" keeps illustrated shaft 128 in a fluid-blocking position in the discharge opening of a syringe body such as body 102, An "operable retaining force" will generally cause txumn failure of a component or element before the plunger can retract from a captured position. in any case, an "operable retaining force" is sufficient to defeat a user fron trusing the syringe assembly without resorting to tools and/or destmyting one or more component, 10064] It is recognized that certain luer-locking joints including a threaded interface can be rotated in an opening direction to generate a significant tensile force in, for example, a distally extending captured shaft. A first locking element that is bonded to, or integral with, a fluid-guiding device might well generate sufficient tensile force as to break a shaft 128 (see FIG. 3), and permit retraction of the plunger 122 from a captured position, and consequently, permit reuse of the syringe, Therefore it is preferred for the first locking element to be engaged to a fluid-guiding device by way of a friction-fit or press-fit, that will inherently be decoupled or otherwise disengaged at a lower tensile load than that requited to either break the shaft 128, or to compromise engagement between capture stricture and a locking element, Consequently, although the captured first locking element may be disengaged from a fltid-guiding device as a user attempts toi unscrew that fluid-guiding device, the first locking element will remain coupled to the capture structure and will resist reuse of the syringe by continuing to resist plunger reciprocation, Essentially the press-fit coupling desirably fotrms a "weakest link" to prevent the plunger fitm breaking at a location that would permit reuse of the syringe [0:0653 The alternative first locking element 182 ilhistrated in FIG, 10 is configured to apply a retaining fictional force to the protruding length of extended shaft 128', As illustrated, the surface of shaft 128' includes a distally-oriented mold-release draft, and consequently, lacks a proximally facing surface, However, the purality of self-biased fingers 184 are configured to apply a frictional force to shaft 128' sufficient to resist proximal etraction of*the syhnge plunger. t i currently believed that a minimum operable distance In to permit a fridtiod-caused retaining force is at least about I times the diameter of an extended shaft 28 [0066] Components of an assembly, such as assembly 100, are typically injection molded. The various components are generally made fionm medical grade plastic, or plastic-like materials, it is currently preferred to fabricate a plunger stem 122 and detachable core 124 from 12 WO 2013/140380 PCT/IB2013/052303 polypropylene or ABS. A workable wiper element can be made from polyisoprene or non-latex polyisoprene. Typically, a syringe body 102 is made from polypropylene. A workable locking element, such as aitemative first locking element 182 iflustrated in FIG, 10, or first locking element 140 illustrated in FIG, 11 can be made from polycarbonate. Cantilevered and self biased fmgers (e.g I84 or I 52) can be embodied as a circwmferentialWyuminterrpted thread-like element, or alra lity of circumferentil)y-intrruptedl elements structured to permit removal of a locking element from an injection mold, (0067] As mentioned above, it, is preferred for the stem 122 to separate ftom the core 124 to further resist reuse of the syringe assembly 100. Many ways to cause such an effect will be apparent to designers of medical products. For example, a stem and core can be injection molded as a unitary piece, wkth a local area of reduced cross-section at a desired decoupling location being struetured to fail (in shear or tension) before a critical cross-section of shtuP 128 fAils in tension and thereby permits retraction of the plunger. {0068] As illustrated between FIGs. 1 and 2, the proximal end of core 124 is molded in registration between distally protruding legs 186 of the stem 122, Raised areas 188 may be configured with even farther reduced crosa-section to reduce a shear-carrying area between the elements and facilitate decoupling, in any case, it is desirable for the pull-apart jint 154 to r'eliably rcmainr together during even aggressive inspiration of fluid into the syringe, but then decouple relatively easily to automatically disable the syringe assembly front reuse. [0069] With particular reference to FIG. 1, the distal end, generally 190, of stem 122 is structured in harmony with a compression bearing area 192 to ensure motion of core 124 in a distal direction responsive to stein displacement in that direction. Such compression interface ensures that sufficient farce can be applied as required to engage locking structure and capture structure to effect an auto-destmct event. (00701 in a currently preferred method of use, a user can inspire fluid Into the syringe, then expel that fluid into a. container to reconstitute a treatment substance Aneedle may first be attached to the syringe to facilitate fluid inspiration and expulsion into a container, such as a vial havn a pierceable top. The syringe can be fully emptied, meaning the plunger is completely depressed to a maximum distal, fluid fuly-expelled position, Treatment substance may then be inspired into the syringe by retracting the plunger stem. Tne user may then couple the syringe with a fluid-guiding attachment that includes a first locking structure, Until first locking 13 WO 2013/140380 PCT/IB2013/052303 structure is affixed to the syringe phger, the syringe can be fully emptied and re-filled a plurality of times. An operable fluid-guidance attachment includes a fuid atomizer, such as may be used for nasal therapy One or more dose of treatment substance may be expelled until the syringe is empty. The user will auto-disable the syringe upon dispensing a dose to enipt the syringe, Sometimes, subsequent to capturing structure of the pluger with a first locking Clement at a position distal to the discharge of the syringe body, the user may pull proximally on the plunger stem to cause separation of a proximal stem portion, leaving behind a proxinally untethered obstruction disposed in penetration through the syringe discharge aperture to resist reuse of the syringe, [0071] Sometimes, a second locking element may be included in certain embodiments of the invention. Certain of such second locking elements may also be used as a stand-alone koxking element. In any case, a second locking element is effective to resist removing a conduit from an installed position in engagement with a conventional luer-lock device. A currently preferred embodiment resists rotation (in a loosening, or disassembly direction), of circurnferentially spaced apart male threads from an installed position inside a female thread, such as is carried at the distal end of many fluid-dispensing syringes. [0072] F'IGs. 12 through 18 illustrate structural details of a first currently preferred embodiment of a second looking element, generaly indicated at 200. Second locking element 200 includes an arcuate wall 202 configured for disposition in engagement around the exteral surface of a generally cylindrical conduit element. An illustxative conduit element includes hub 204 in Fit), 17T Hub 204 is a portion of a fluid atomizer 205 (sec FIO, 18) A wide rane in alternative conduit structures may be used in combination with certain embodiments of second locking elements according to certain principles of the invention, Non-limiting examples of workable conduit structures include: needle hubs, conduit connectors, fluid atomizers, and the like, A second locking element may be used" for example, to resist removal of fluid-guiding structure from a fixed and permanent attachment to a syringe. [0073] Rub 204 is configured to interface with conventional lier-lock structure of a luer-lock device, such as is carried at the dispe nsing (distal) end of certain fluid-dispensing syringes. Hub 204 includes an internal bre 206 corfigured to couple in fluid-tight engagement with a male lier of the conventional luer-lock device, A proximal end of hub 204 caries circunferentially interrupted male threads, 208 and 210, respectively, that are structured to 14 WO 2013/140380 PCT/IB2013/052303 couple with a female thread of the hierdock device. {00741 Wall 202 includes a band portion, generally 212, configured to wrap around a sufficient portion of the circumference of conduit 204 to resist radial separation between acuate wall 202 and conduit 204. Tne illstrated hand portion 212 is cofigured to wrap around more than half the circumference of bub 204. An alternative configuration within contemplation includes a proximal surface having a thrugh-hole to permit engagement of a male luer inside bore 206, and a pair of distally projecting arms that together form an alternatively configured circumferentially interrupted wall. [0075) Desirably, band 212 includes at least a first blocking portion, generally 213 in F1, 14, forming a stmctural interference 'with at least one of male threads 208, 210 to resist axial displacement of the wall 202 in a proximal direction with respect to conduit 204. At least tne proximally projecting tang portion 214 of wall 202 is sized to fit into a circumferential space between the male threads 208, 210 and thereby cause a structural interference with one of threads 208, 210 to resist rotation of an installed wall 202 about the centerline of bore 206. G0076} Wall 202 also carries a flap 216 with a leading edge generally indicated at 218, and a trailng edge generally indicated at 220. Desirably, leading edge 218 is configured to facilitate rotation of wall 202 in a tightening direction when an assembly is installed in a luer lock device. illustrated leading edge 218 is radiused and disposed in sufficient radial proximity to the surface 222 as to rotatably fit into the female thread of a luer-lock device without interference In contrast, flap 216 includes cantilevered portion extending to the wailing edge 220 that is configured to develop a selfbias as male threads 208, 210 are rotated in a tightening direction with respect to the female thread of the hueriock device. Further the trailing edge 220 is configured to cause a structural interference with the female thread to resist rotation of male threads 208, 210 in a loosening direction As illustrated, trailing edge 220 may be sharpened. 'railing edge 220 may also be twisted to cause a comer, generally indicated at 224 in FIGs. 16 and 17, to preferentially contact, and dig into, tbe material fbning the female thread (e g. 226 in FiG. 18) of a hier-iock device. A desirable twist in flap 216 also facilitates entrance of the proximal end of hub 204 into the opening of the female thread ofa luer-lock device. {0077] It is whhin contemplation that a second locking element structured according to certain principles of the invention may include one or more second blocking structure to resist displacement of an installed locking clement in a distal diretion. For example, the corner 15 WO 2013/140380 PCT/IB2013/052303 generally indicated at 230 in FIG. 17 may be bent radially inward subsequent to installation of Picking element 200 onto hub 204, Altemative structure may be provided to essentiadly form a finger carried at a proximal end of wal 202, with the finger projecting radially inward to cause a strucual interference with a proximaly facing surface, such as surface 232, of hab 204 to resist axial displacement of an installed wail 202 in a distal direction with respect to the hub 204, [0078] A second embodiment of a workable second kocking element is illustrated in FIGs. 19 through 25, and is generally indicated at 240. An exemplary second locking element 240 may be made by cutting the plan foer generally indicated at 242 in FIG. 25 from thin Stainless Steei sheet stock, The plan form 242 may then be rolled-up around an axis 243 to form a generally cylindrical section having a cantilevered tongue 244. The tip of the tongue 244, generally 246, may be sharpened, or even arranged to have a point, to facilitate making biting contact with a female thread 226, A tang 214' is slzed to be received between male threads 208, 2.10, A void 248 is sized to receive a male thread 208 or.210, [0079] Desirably, a second locking element is made from metal, such as Stainless SteeL Thin Stainless Steel sheet stock advantageously can fit into the relatively small available radial sace in a luerdock device, Also, such material is strong enough to resist undesired rotation of components without experiencing stmctural failure. Farther, such material can be configured to "hie" well into the (typically) plastic female thread of a luer-lock device to form a strUctural interference; 16