AU2013202825A1

AU2013202825A1 - Aminopyrimidine derivatives as LRRK2 modulators

Info

Publication number: AU2013202825A1
Application number: AU2013202825A
Authority: AU
Inventors: Charles Baker-Glenn; Daniel Jon Burdick; Mark Chambers; Bryan K. Chan; Huifen Chen; Anthony Estrada; Janet L. Gunzner; Daniel Shore; Zachary Kevin Sweeney; Shumei Wang; Guiling Zhao
Original assignee: F Hoffmann La Roche AG
Current assignee: F Hoffmann La Roche AG
Priority date: 2010-06-04
Filing date: 2013-04-08
Publication date: 2013-05-02

Abstract

AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS Abstract Compounds of the formula I or pharmaceutically acceptable salts thereof, wherein m, n, X, R', R2, R', R , R' and R7 are as defined herein. Also disclosed are methods of making the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.

Description

1 AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS FIELD OF THE INVENTION This invention pertains to compounds that modulate the function of LRRK2 and are useful for treatment of LRRK2-mediated diseases and conditions such as Parkinson's disease. BACKGROUND OF THE INVENTION 5 Neurodegenerative diseases such as Parkinson's disease, Lewy body dementia and Huntington's disease affect millions of individuals. Parkinson's disease is a chronic, progressive motor system disorder that afflicts approximately one out of every 1000 people, with hereditary Parkinson's disease accounting for 5-10% of all of patients. Parkinson's disease is caused by progressive loss of mid-brain dopamine neurons, leaving patients with impaired ability to direct 10 and control their movements. The primary Parkinson's disease symptoms are trembling, rigidity, slowness of movement, and impaired balance. Many Parkinson's disease patients also experience other symptoms such as emotional changes, memory loss, speech problems, and sleeping disorders. The gene encoding the leucine-rich repeat kinase 2 protein (LRRK2) has been identified 15 in association with hereditary Parkinson's disease (Paisan-Ruiz et al., Neuron, Vol. 44(4), 2004, pp 595-600; Zimprich et al., Neuron, Vol. 44(4), 2004, 601-607). In-vitro studies show that Parkinson's disease -associated mutation leads to increased LRRK2 kinase activity and decreased rate of GTP hydrolysis compared to wild-type (Guo et al., Experimental Cell Research, Vol. 313(16), 2007, pp. 3658-3670. Anti-LRRK2 antibodies have been used to label brainstem Lewy 20 bodies associated with Parkinson's disease and cortical antibodies associated with Lewis body dementia suggesting that LRRK2 may play an important role in Lewie body formation and pathogenesis associated with these diseases (Zhou et al., Molecular Degeneration, 2006, 1:17 doi:10.1186/1750-1326-1-17). LRRK2 has also been identified as a gene potentially associated with increased susceptibility to Crohn's disease and susceptibility to leprosy (Zhang et al., New 25 England J. Med. Vol. 361 (2009) pp.

2 6 0 9

-

2 6 18 . LRRK2 has also been associated with the transition of mild cognitive impairment to Alzheimer's disease (W02007/149789); L-Dopa induced dyskinesia (Hurley et al., Eur. J. Neurosci., Vol. 26, 2007, pp. 171-177; CNS disorders associated with neuronal progenitor differentiation (Milosevic et al., Neurodegen., Vol. 4, 2009, p. 25); cancers such as kidney, 30 breast, prostate, blood and lung cancers and acute myelogenous leukemia (W02011/038572); papillary renal and thyroid carcinomas (Looyenga et al., www.pnas.org/cgi/doi/10.1073/pnas.1012500108); multiple myeloma (Chapman et al., Nature Vol. 471, 2011, pp. 467-472); amyotrophic lateral sclerosis (Shtilbans et al., Amyotrophic 2 Lateral Sclerosis "Early Online 2011, pp. 1-7); rheumatoid arthritis (Nakamura et al., DNA Res. Vol. 13(4), 2006, pp. 169-183); and ankylosing spondylytis (Danoy et al., PLoS Genetics, Vol. 6(12), 2010, e1001195, pp. 1-5). Accordingly, compounds and compositions effective at modulating LRRK2 activity may 5 provide a treatment for neurodegenerative diseases such as Parkinson's disease and Lewie body dementia, for CNS disorders such as Alzheimer's disease and L-Dopa induced dyskinesia, for cancers such as kidney, breast, prostate, blood, papillary and lung cancers, acute myelogenous leukemia and multiple myeloma, and for inflammatory diseases such as leprosy, Crohn's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, and ankylosing spondylytis. Particularly, 10 there is a need for compounds with LRRK2 affinity that are selective for LRRK2 over other kinases, such as JAK2, and which can provide effective drugs for treatment of neurodegenerative disorders such as Parkinson's disease. SUMMARY OF THE INVENTION The invention provides compounds of the formula I: R5 ,X R 6 R2OP N N 0 N~ N7 H (R 7 )m 15 R3 or pharmaceutically acceptable salts thereof, wherein: m is from 0 to 3; X is: -NRa-; -0-; or -S(O)r- wherein r is from 0 to 2 and Ra is hydrogen or C1- 6 alkyl; 20 R 1 is: Ci- 6 alkyl; C 2

-

6 alkenyl; C 2

-

6 alkynyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-Ci- 6 alkyl; hydroxy

C

2

-

6 alkenyl; amino-Ci- 6 alkyl; Ci- 6 alkylsulfonyl-Ci- 6 alkyl; C 3

_

6 cycloalkyl optionally substituted with Ci 6 alkyl; C 3

_

6 cycloalkyl-Ci 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-Cip 6 alkyl; oxetanyl; or oxetan-Ci_ 6 alkyl; 25 or R 1 and Ra together with the atoms to which they are attached may form a three to six membered ring that may optionally include an additional heteroatom selected from 0, N and S, and which is substituted with oxo, halo or C1- 6 alkyl; 3 R2 is: halo; C1_alkoxy; cyano; C 2

_

6 alkynyl; C 2

_

6 alkenyl; halo-C1_ 6 alkyl; halo-CI 6 alkoxy;

C

3

-

6 cycloalkyl wherein the C 3

-

6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; C 3 _ 6 cycloalkyl-CI- 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with Ci- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; acetyl; oxetanyl; or oxetan-C1_ 6 alkyl; 5 R3 is: -OR 4 ; halo; cyano; C1 6 alkyl; halo-C 1 6 alkyl; C 3 6 cycloalkyl optionally substituted with CI- 6 alkyl; C 3

_

6 cycloalkyl-Ci- 6 alkyl wherein the C3- 6 cycloalkyl portion is optionally substituted with C1-6alkyl; tetrahydrofuranyl; tetrahydrofuranyl-CI_ 6 alkyl; oxetanyl; or oxetan-C1 6 alkyl; R4 is: Ci- 6 alkyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-CI 6 alkyl; C 3

-

6 cycloalkyl optionally substituted 10 with C1_ 6 alkyl or halo; C 3

_

6 cycloalkyl-C1_ 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with CI 6 alkyl or halo; tetrahydrofuranyl; tetrahydrofuranyl-CI 6 alkyl; oxetanyl; or oxetan-Ci- 6 alkyl; R' is: hydrogen; or CI- 6 alkyl; n is 0 or 1; 15 R6 is: hydrogen; CI_ 6 alkyl; CI- 6 alkoxy-CI- 6 alkyl; hydroxy-Ci- 6 alkyl; amino-Ci_ 6 alkyl; C 3 6 cycloalkyl; C 3

-

6 cycloalkyl-C1- 6 alkyl; heterocyclyl; or heterocyclyl-C1_ 6 alkyl; wherein the C 3 _ 6 cycloalkyl, C 3

-

6 cycloalkyl-CI- 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be optionally substituted with one, two, three or four groups groups independently selected from: Cj 6 alkyl; halo-CI 6 alkyl; C1i 6 alkoxy; halo-C I 6 alkoxy; hydroxy; hydroxy-Ci- 6 alkyl; halo; nitrile; 20 Ci- 6 alkyl-carbonyl; C1_ 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3

_

6 cycloalkyl-C1_ 6 alkyl; C 3

_

6 cycloalkyl carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; or R5 and R6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that optionally includes an additional heteroatom selected from 0, N and 25 S(O)n, and which is optionally substituted with one, two, three or four groups independently selected from: Ci- 6 alkyl; halo-C I 6 alkyl; CI_ 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI 6 alkyl; halo, nitrile; Ci- 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3

-

6 cycloalkyl-C1- 6 alkyl; C 3 _ 6 CyCloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; and 30 R7 is: halo; CI 6 alkyl; Ci- 6 alkoxy; halo-CI 6 alkyl; or halo-Ci- 6 alkoxy. Furthermore, the invention includes all optical isomers, i.e. diastereoisomers, diastereomeric mixtures, racemic mixtures, all their corresponding enantiomers and/or tautomers as well as their solvates of the compounds of formula I.

4 The invention also provides and pharmaceutical compositions comprising the compounds, methods of using the compounds, and methods of preparing the compounds. DETAILED DESCRIPTION OF THE INVENTION Definitions 5 Unless otherwise stated, the following terms used in this Application, including the specification and claims, have the definitions given below. It must be noted that, as used in the specification and the appended claims, the singular forms "a", "an," and "the" include plural referents unless the context clearly dictates otherwise. "Acetyl", alone or in combination with other groups, means the group -C=O-CH 3 . 10 "Alkyl", alone or in combination with other groups, means the monovalent linear or branched saturated hydrocarbon moiety, consisting solely of carbon and hydrogen atoms, having from one to twelve carbon atoms. "Lower alkyl" refers to an alkyl group of one to six carbon atoms, i.e. C1- 6 alkyl. Examples of alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, isobutyl, see butyl, tert butyl, pentyl, n-hexyl, octyl, dodecyl, and the like. 15 "Alkenyl", alone or in combination with other groups, means a linear monovalent hydrocarbon radical of two to six carbon atoms or a branched monovalent hydrocarbon radical of two to six carbon atoms, i.e. C 2

_

6 alkenyl containing at least one double bond, e.g., ethenyl, propenyl, and the like. "Alkynyl", alone or in combination with other groups, means a linear monovalent 20 hydrocarbon radical of two to six carbon atoms or a branched monovalent hydrocarbon radical of two to six carbon atoms, i.e. C 2

_

6 alkynyl containing at least one triple bond, e.g., ethynyl, propynyl, and the like. "Alkylene", alone or in combination with other groups, means a linear saturated divalent hydrocarbon radical of one to six carbon atoms or a branched saturated divalent hydrocarbon 25 radical of three to six carbon atoms, e.g., methylene, ethylene, 2,2-dimethylethylene, propylene, 2-methylpropylene, butylene, pentylene, and the like. "Alkoxy" and "alkyloxy", alone or in combination with other groups, which may be used interchangeably, mean a moiety of the formula -OR, wherein R is an alkyl moiety as defined herein. Examples of alkoxy moieties include, but are not limited to, methoxy, ethoxy, isopropoxy, 30 and the like. "Alkoxyalkyl", alone or in combination with other groups, means a moiety of the formula Ra-O-Rb-, where Ra is alkyl and Rb is alkylene as defined herein, e.g. Ci- 6 alkoxy-CI- 6 alkyl. Exemplary alkoxyalkyl groups include, by way of example, 2-methoxyethyl, 3-methoxypropyl, 5 1-methyl-2-methoxyethyl, 1-(2-methoxyethyl)-3-methoxypropyl, and 1-(2-methoxyethyl)-3 methoxypropyl. "Alkoxyalkoxy', alone or in combination with other groups, means a group of the formula -O-R-R' wherein R is alkylene and R' is alkoxy as defined herein. 5 "Alkylcarbonyl", alone or in combination with other groups, means a moiety of the formula -C(O)-R, wherein R is alkyl as defined herein, e.g. C1_ 6 alkyl-carbonyl. "Alkoxycarbonyl" , alone or in combination with other groups, means a group of the formula -C(O)-R wherein R is alkoxy as defined herein, e.g. CI- 6 alkoxy-carbonyl. "Alkylcarbonylalkyl", alone or in combination with other groups, means a group of the 10 formula -R-C(O)-R wherein R is alkylene and R' is alkyl as defined herein, e.g. CI- 6 alkyl carbonyl-C1_ 6 alkyl. "Alkoxycarbonylalkyl" , alone or in combination with other groups, means a group of the formula -R-C(O)-R wherein R is alkylene and R' is alkoxy as defined herein, e.g. CI- 6 alkoxy carbonyl-C1- 6 alkyl.. 15 "Alkoxycarbonylalkoxy", alone or in combination with other groups, means a group of the formula -O-R-C(O)-R' wherein R is alkylene and R' is alkoxy as defined herein e.g. C 1 _ 6 alkoxy-carbonyl-C1- 6 alkoxy. "Hydroxycarbonylalkoxy", alone or in combination with other groups, means a group of the formula -O-R-C(O)-OH wherein R is alkylene as defined herein, e.g. -CI 6 alkoxy-carbonyl 20 OH. "Alkylaminocarbonylalkoxy", alone or in combination with other groups, means a group of the formula -O-R-C(O)-NHR' wherein R is alkylene and R' is alkyl as defined herein. "Dialkylaminocarbonylalkoxy", alone or in combination with other groups, means a group of the formula -O-R-C(O)-NR'R" wherein R is alkylene and R' and R" are alkyl as 25 defined herein. "Alkylaminoalkoxy", alone or in combination with other groups, means a group of the formula -O-R-NHR' wherein R is alkylene and R' is alkyl as defined herein. "Dialkylaminoalkoxy", alone or in combination with other groups, means a group of the formula -O-R-NR'R' wherein R is alkylene and R' and R" are alkyl as defined herein. 30 "Alkylsulfonyl", alone or in combination with other groups, means a moiety of the formula - S0 2 -R, wherein R is alkyl as defined herein, e.g. CI- 6 alkyl-sulfonyl.

6 "Alkyl-heterocyclyl", alone or in combination with other groups, means a moiety of the formula Ci- 6 alkyl-R, wherein R is heterocyclyl as defined herein, e.g. Ci- 6 alkyl-heterocyclyl. "Alkylsulfonylalkyl", alone or in combination with other groups, means a moiety of the formula -R'-S0 2 -R" where where R' is alkylene and R" is alkyl as defined herein, e.g. Ci_ 5 6 alkylsulfonyl-Ci- 6 alkyl. "Alkylsulfonylalkoxy", alone or in combination with other groups, means a group of the formula -O-R-S0 2 -R' wherein R is alkylene and R' is alkyl as defined herein. "Amino", alone or in combination with other groups, means a moiety of the formula NRR' wherein R and R' each independently is hyrdogen or alkyl as defined herein. "Amino thus 10 includes "alkylamino (where one of R and R' is alkyl and the other is hydrogen) and "dialkylamino (where R and R' are both alkyl. "Aminocarbonyl", alone or in combination with other groups, means a group of the formula -C(O)-R wherein R is amino as defined herein. "Alkoxyamino", alone or in combination with other groups, means a moiety of the 15 formula -NR-OR' wherein R is hydrogen or alkyl and R' is alkyl as defined herein. "Alkylsulfanyl", alone or in combination with other groups, means a moiety of the formula -SR wherein R is alkyl as defined herein. "Aminoalkyl", alone or in combination with other groups, means a group -R-R' wherein R' is amino and R is alkylene as defined herein, e.g. amino-Ci_ 6 alkyl. "Aminoalkyl" includes 20 aminomethyl, aminoethyl, 1-aminopropyl, 2-aminopropyl, and the like. The amino moiety of "aminoalkyl" may be substituted once or twice with alkyl to provide "alkylaminoalkyl" and "dialkylaminoalkyl" respectively. "Alkylaminoalkyl" includes methylaminomethyl, methylaminoethyl, methylaminopropyl, ethylaminoethyl and the like. "Dialkylaminoalkyl" includes dimethylaminomethyl, dimethylaminoethyl, dimethylaminopropyl, N-methyl-N 25 ethylaminoethyl, and the like. "Aminoalkoxy", alone or in combination with other groups, means a group -OR-R' wherein R' is amino and R is alkylene as defined herein. "Alkylsulfonylamido", alone or in combination with other groups, means a moiety of the formula -NR'S0 2 -R wherein R is alkyl and R' is hydrogen or alkyl. 30 "Aminocarbonyloxyalkyl" or "carbamylalkyl", alone or in combination with other groups, means a group of the formula -R-0-C(O)-NR'R" wherein R is alkylene and R', R" each independently is hydrogen or alkyl as defined herein.

7 "Alkynylalkoxy", alone or in combination with other groups, means a group of the formula -O-R-R' wherein R is alkylene and R' is alkynyl as defined herein. "Aryl", alone or in combination with other groups, means a monovalent cyclic aromatic hydrocarbon moiety consisting of a mono-, bi- or tricyclic aromatic ring. The aryl group can be 5 optionally substituted as defined herein. Examples of aryl moieties include, but are not limited to, phenyl, naphthyl, phenanthryl, fluorenyl, indenyl, pentalenyl, azulenyl, oxydiphenyl, biphenyl, methylenediphenyl, aminodiphenyl, diphenylsulfidyl, diphenylsulfonyl, diphenylisopropylidenyl, benzodioxanyl, benzofuranyl, benzodioxylyl, benzopyranyl, benzoxazinyl, benzoxazinonyl, benzopiperadinyl, benzopiperazinyl, benzopyrrolidinyl, benzomorpholinyl, 10 methylenedioxyphenyl, ethylenedioxyphenyl, and the like, of which may be optionally substituted as defined herein. "Arylalkyl" and "Aralkyl", , alone or in combination with other groups, which may be used interchangeably, mean a radical-RaR where Ra is an alkylene group and Rb is an aryl group as defined herein; e.g., phenylalkyls such as benzyl, phenylethyl, 3-(3-chlorophenyl)-2 15 methylpentyl, and the like are examples of arylalkyl. "Arylsulfonyl", alone or in combination with other groups, means a group of the formula -S0 2 -R wherein R is aryl as defined herein. "Aryloxy", alone or in combination with other groups, means a group of the formula -0 R wherein R is aryl as defined herein. 20 "Aralkyloxy", alone or in combination with other groups, means a group of the formula O-R-R" wherein R is alkylene and R' is aryl as defined herein. "Carboxy" or "hydroxycarbonyl",, alone or in combination with other groups, which may be used interchangeably, means a group of the formula -C(O)-OH. "Cyanoalkyl", alone or in combination with other groups, means a moiety of the 25 formula -R'-R", where R' is alkylene as defined herein and R" is cyano or nitrile. "Cycloalkyl", alone or in combination with other groups, means a monovalent saturated carbocyclic moiety consisting of mono- or bicyclic rings, e.g. C 3

-

6 cycloalkyl. Particular cycloalkyl are unsubstituted or substituted with alkyl. Cycloalkyl can optionally be substituted as defined herein. Unless defined otherwise, cycloalkyl may be optionally substitued with one or 30 more substituents, wherein each substituent is independently hydroxy, alkyl, alkoxy, halo, haloalkyl, amino, monoalkylamino, or dialkylamino. Examples of cycloalkyl moieties include, but are not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and the like, including partially unsaturated (cycloalkenyl) derivatives thereof.

8 "Cycloalkylalkyl", alone or in combination with other groups, means a moiety of the formula -R'-R", where R' is alkylene and R" is cycloalkyl as defined herein, e.g. C 3 _ 6 cycloalkyl-C1- 6 alkyl. "Cycloalkylalkoxy" , alone or in combination with other groups, means a group of the 5 formula -O-R-R' wherein R is alkylene and R' is cycloalkyl as defined herein. "Cycloalkylcarbonyl", alone or in combination with other groups, means a moiety of the formula -C(O)-R, wherein R is cycloalkyl as defined herein, e.g. C 3

-

6 cycloalkyl-carbonyl. "Heteroaryl", alone or in combination with other groups, means a monocyclic or bicyclic radical of 5 to 12 ring atoms having at least one aromatic ring containing one, two, or three ring 10 heteroatoms selected from N, 0, or S, the remaining ring atoms being C, with the understanding that the attachment point of the heteroaryl radical will be on an aromatic ring. The heteroaryl ring may be optionally substituted as defined herein. Examples of heteroaryl moieties include, but are not limited to, optionally substituted imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, pyrazinyl, thienyl, benzothienyl, thiophenyl, furanyl, 15 pyranyl, pyridyl, pyrrolyl, pyrazolyl, pyrimidyl, quinolinyl, isoquinolinyl, benzofuryl, benzothiophenyl, benzothiopyranyl, benzimidazolyl, benzooxazolyl, benzooxadiazolyl, benzothiazolyl, benzothiadiazolyl, benzopyranyl, indolyl, isoindolyl, triazolyl, triazinyl, quinoxalinyl, purinyl, quinazolinyl, quinolizinyl, naphthyridinyl, pteridinyl, carbazolyl, azepinyl, diazepinyl, acridinyl and the like, each of which may be optionally substituted as defined herein. 20 "Heteroarylalkyl" or "heteroaralkyl", alone or in combination with other groups, means a group of the formula -R-R' wherein R is alkylene and R' is heteroaryl as defined herein. "Heteroarylsulfonyl", alone or in combination with other groups, means a group of the formula -S0 2 -R wherein R is heteroaryl as defined herein. "Heteroaryloxy", alone or in combination with other groups, means a group of the 25 formula -0-R wherein R is heteroaryl as defined herein. "Heteroaralkyloxy", alone or in combination with other groups, means a group of the formula -O-R-R" wherein R is alkylene and R' is heteroaryl as defined herein. The terms "halo", "halogen" and "halide", alone or in combination with other groups, which may be used interchangeably, refer to a substituent fluoro (F), chloro (Cl), bromo (Br), or 30 iodo (I). "Haloalkyl", alone or in combination with other groups, means alkyl as defined herein in which one or more hydrogen has been replaced with same or different halogen, e.g. halo-C 1 _ 6 alkyl. Particular is fluoro-CI- 6 alkyl. Exemplary haloalkyls include -CH 2 Cl, -CH 2

CF

3 ,

-CH

2 CCl 3 , perfluoroalkyl (e.g., -CF 3 ), and the like.

9 "Haloalkoxy", alone or in combination with other groups, means a moiety of the formula -OR, wherein R is a haloalkyl moiety as defined herein, e.g. halo-CI- 6 alkoxy. An exemplary haloalkoxy is difluoromethoxy. "Heterocycloamino", alone or in combination with other groups, means a saturated ring 5 wherein at least one ring atom is N, NH or N-alkyl and the remaining ring atoms form an alkylene group. "Heterocyclyl", alone or in combination with other groups, means a monovalent saturated moiety, consisting of one to three rings, incorporating one, two, or three or four heteroatoms (chosen from nitrogen, oxygen or sulfur). The heterocyclyl ring may be optionally substituted as 10 defined herein. Examples of heterocyclyl moieties include, but are not limited to, optionally substituted piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azepinyl, pyrrolidinyl, azetidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl and the like. Such heterocyclyl may be optionally substituted as defined herein. Particular are morpholinyl, piperidinyl, octahydro pyrido[1,2-a]pyrazinyl, azetidinyl, piperazinyl, pyrrolidinyl, piperidinyl, tetrahydropyranyl, 15 [1,4]oxazepanyl, 3-oxa-8-aza-bicyclo[3.2.1]octyl, 2-oxa-5-aza-bicyclo[2.2.1]heptyl, (1S,4S)-2 oxa-5-azabicyclo[2.2.1]heptanyl, 8-oxa-3-aza-bicyclo[3.2.1]octyl, 2-oxa-6-aza-spiro[3.3]heptyl, pyrimidinyl and oxetan-3-yl. Specific are morpholin-4-yl, piperidin-1-yl, octahydro-pyrido[1,2 a]pyrazin-2-yl, azetidin-1-yl, piperazin-1-yl, pyrrolidin-1-yl, piperidin-4-yl, tetrahydropyran-3-yl, [1,4]oxazepan-4-yl, 3-oxa-8-aza-bicyclo[3 .2.1 ]oct-8-yl, 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl, 20 (1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl, 8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl, 2-oxa-6-aza spiro[3.3]hept-6-yl, pyrimidin-5-yl and oxetan-3-yl. "Heterocyclylalkyl", alone or in combination with other groups, means a moiety of the formula -R-R' wherein R is alkylene and R' is heterocyclyl as defined herein, e.g. heterocyclyl C1- 6 alkyl. 25 "Heterocyclyloxy", alone or in combination with other groups, means a moiety of the formula -OR wherein R is heterocyclyl as defined herein. "Heterocyclylalkoxy", alone or in combination with other groups, means a moiety of the formula -OR-R' wherein R is alkylene and R' is heterocyclyl as defined herein. "Hydroxy", alone or in combination with other groups means a group -OH. 30 "Hydroxyalkoxy", alone or in combination with other groups, means a moiety of the formula -OR wherein R is hydroxyalkyl as defined herein. "Hydroxyalkylamino", alone or in combination with other groups, means a moiety of the formula -NR-R' wherein R is hydrogen or alkyl and R' is hydroxyalkyl as defined herein.

10 "Hydroxyalkylaminoalkyl", alone or in combination with other groups, means a moiety of the formula -R-NR'-R" wherein R is alkylene, R' is hydrogen or alkyl, and R" is hydroxyalkyl as defined herein. "Hydroxycarbonylalkyl" or "carboxyalkyl", alone or in combination with other groups, 5 means a group of the formula -R-(CO)-OH where R is alkylene as defined herein. "Hydroxycarbonylalkoxy" , alone or in combination with other groups, means a group of the formula -O-R-C(O)-OH wherein R is alkylene as defined herein. "Hydroxyalkyloxycarbonylalkyl" or "hydroxyalkoxycarbonylalkyl", alone or in combination with other groups, means a group of the formula -R-C(O)-O-R-OH wherein each R 10 is alkylene and may be the same or different. "Hydroxyalkyl", alone or in combination with other groups, means an alkyl moiety as defined herein, substituted with one or more, for example, one, two or three hydroxy groups, provided that the same carbon atom does not carry more than one hydroxy group, e.g. hydroxy

CI-

6 alkyl. Representative examples include, but are not limited to, hydroxymethyl, 2 15 hydroxyethyl, 2-hydroxypropyl, 3-hydroxypropyl, 1-(hydroxymethyl)-2-methylpropyl, 2 hydroxybutyl, 3-hydroxybutyl, 4-hydroxybutyl, 2,3-dihydroxypropyl, 2-hydroxy- 1 hydroxymethylethyl, 2,3-dihydroxybutyl, 3,4-dihydroxybutyl and 2-(hydroxymethyl)-3 hydroxypropyl. "Hydroxycycloalkyl", alone or in combination with other groups, means a cycloalkyl 20 moiety as defined herein wherein one, two or three hydrogen atoms in the cycloalkyl radical have been replaced with a hydroxy substituent. Representative examples include, but are not limited to, 2-, 3-, or 4-hydroxycyclohexyl, and the like. "Alkoxy hydroxyalkyl" and "hydroxy alkoxyalkyl", alone or in combination with other groups, which may be used interchangeably, means an alkyl as defined herein that is substituted 25 at least once with hydroxy and at least once with alkoxy. "Alkoxy hydroxyalkyl" and "hydroxy alkoxyalkyl" thus encompass, for example, 2-hydroxy-3-methoxy-propan-1-yl and the like. "Urea"or "ureido", alone or in combination with other groups, means a group of the formula -NR'-C(O)-NR"R'" wherein R', R" and R.' each independently is hydrogen or alkyl. "Carbamate", alone or in combination with other groups, means a group of the formula 30 O-C(O)-NR'R" wherein R' and R" each independently is hydrogen or alkyl. "Carboxy", alone or in combination with other groups, means a group of the formula -0

C(O)-OH.

11 "Sulfonamido", alone or in combination with other groups, means a group of the formula -S0 2 -NR'R" wherein R', R" and R." each independently is hydrogen or alkyl. "Optionally substituted" when used in association with an "aryl", phenyl", "heteroaryl" "cycloalkyl" or "heterocyclyl" moiety means that such moiety may be unsubstituted (i.e., all 5 open valencies are occupied by a hydrogen atom) or substituted with specific groups as related herein. "Leaving group" means the group with the meaning conventionally associated with it in synthetic organic chemistry, i.e., an atom or group displaceable under substitution reaction conditions. Examples of leaving groups include, but are not limited to, halogen, alkane- or 10 arylenesulfonyloxy, such as methanesulfonyloxy, ethanesulfonyloxy, thiomethyl, benzenesulfonyloxy, tosyloxy, and thienyloxy, dihalophosphinoyloxy, optionally substituted benzyloxy, isopropyloxy, acyloxy, and the like. "Modulator" means a molecule that interacts with a target. The interactions include, but are not limited to, agonist, antagonist, and the like, as defined herein. 15 "Nitrile" or "cyano", alone or in combination with other groups means a group -C-N. "Optional" or "optionally" means that the subsequently described event or circumstance may but need not occur, and that the description includes instances where the event or circumstance occurs and instances in which it does not. "Disease" and "Disease state" means any disease, condition, symptom, disorder or 20 indication. "Inert organic solvent" or "inert solvent" means the solvent is inert under the conditions of the reaction being described in conjunction therewith, including for example, benzene, toluene, acetonitrile, tetrahydrofuran, N,N-dimethylformamide, chloroform, methylene chloride or dichloromethane, dichloroethane, diethyl ether, ethyl acetate, acetone, methyl ethyl ketone, 25 methanol, ethanol, propanol, isopropanol, tert-butanol, dioxane, pyridine, and the like. Unless specified to the contrary, the solvents used in the reactions of the present invention are inert solvents. "Pharmaceutically acceptable" means that which is useful in preparing a pharmaceutical composition (i.e. a composition) that is generally safe, non-toxic, and neither biologically nor 30 otherwise undesirable and includes that which is acceptable for veterinary as well as human pharmaceutical use. "Pharmaceutically acceptable salts" of a compound means salts that are pharmaceutically acceptable, as defined herein, and that possess the desired pharmacological activity of the parent compound.

12 It should be understood that all references to pharmaceutically acceptable salts include solvent addition forms (solvates) or crystal forms (polymorphs) as defined herein, of the same acid addition salt. Examples of suitable salts with inorganic and organic acids are, but are not limited to 5 acetic acid, citric acid, formic acid, fumaric acid, hydrochloric acid, lactic acid, maleic acid, malic acid, methane-sulfonic acid, nitric acid, phosphoric acid, p-toluenesulphonic acid, succinic acid, sulfuric acid, sulphuric acid, tartaric acid, trifluoroacetic acid and the like. Preferred are formic acid, trifluoroacetic acid and hydrochloric acid. The terms "pharmaceutically acceptable carrier" and "pharmaceutically acceptable 10 auxiliary substance" refer to carriers and auxiliary substances such as diluents or excipients that are compatible with the other ingredients of the formulation. The term "pharmaceutical composition" or referred to as "composition" encompasses a product comprising specified ingredients in pre-determined amounts or proportions, as well as any product that results, directly or indirectly, from combining specified ingredients in specified 15 amounts. Preferably it encompasses a product comprising one or more active ingredients, and an optional carrier comprising inert ingredients, as well as any product that results, directly or indirectly, from combination, complexation or aggregation of any two or more of the ingredients, or from dissociation of one or more of the ingredients, or from other types of reactions or interactions of one or more of the ingredients. 20 "Protective group" or "protecting group" means the group which selectively blocks one reactive site in a multifunctional compound such that a chemical reaction can be carried out selectively at another unprotected reactive site in the meaning conventionally associated with it in synthetic chemistry. Certain processes of this invention rely upon the protective groups to block reactive nitrogen and/or oxygen atoms present in the reactants. For example, the terms 25 "amino-protecting group" and "nitrogen protecting group" are used interchangeably herein and refer to those organic groups intended to protect the nitrogen atom against undesirable reactions during synthetic procedures. Exemplary nitrogen protecting groups include, but are not limited to, trifluoroacetyl, acetamido, benzyl (Bn), benzyloxycarbonyl (carbobenzyloxy, CBZ), p methoxybenzyloxycarbonyl, p-nitrobenzyloxycarbonyl, tert-butoxycarbonyl (BOC), and the like. 30 The artisan in the art will know how to chose a group for the ease of removal and for the ability to withstand the following reactions. "Solvates" means solvent additions forms that contain either stoichiometric or non stoichiometric amounts of solvent. Some compounds have a tendency to trap a fixed molar ratio of solvent molecules in the crystalline solid state, thus forming a solvate. If the solvent is water 35 the solvate formed is a hydrate, when the solvent is alcohol, the solvate formed is an alcoholate. Hydrates are formed by the combination of one or more molecules of water with one of the 13 substances in which the water retains its molecular state as H 2 0, such combination being able to form one or more hydrate. "Parkinson's disease" means a degenerative disorder of the central nervous system that impairs motor skills, speech, and/or cognitive function. Symptoms of Parkinson's disease may 5 include, for example, muscle rigidity, tremor, slowing of physical movement (bradykinesia) and loss of physical movement (akinesia). "Lewie body disease" also called "Lewie body demntia", diffuse Lewy body disease", cortical Lewie body disease", means a neurogenerative disorder characterized anatomically by the presence of Lewie bodies in the brain. 10 "Subject" means mammals and non-mammals. Mammals means any member of the mammalia class including, but not limited to, humans; non-human primates such as chimpanzees and other apes and monkey species; farm animals such as cattle, horses, sheep, goats, and swine; domestic animals such as rabbits, dogs, and cats; laboratory animals including rodents, such as rats, mice, and guinea pigs; and the like. Examples of non-mammals include, but are not limited 15 to, birds, and the like. The term "subject" does not denote a particular age or sex. The term "half maximal inhibitory concentration" (IC 5 o) denotes the concentration of a particular compound required for obtaining 50% inhibition of a biological process in vitro. IC 50 values can be converted logarithmically to pIC 5 o values (-log IC 50 ), in which higher values indicate exponentially greater potency. The IC 50 value is not an absolute value but depends on 20 experimental conditions e.g. concentrations employed. The ICo value can be converted to an absolute inhibition constant (Ki) using the Cheng-Prusoff equation (Biochem. Pharmacol. (1973) 22:3099). The term "inhibition constant" (Ki) denotes the absolute binding affinity of a particular inhibitor to a receptor. It is measured using competition binding assays and is equal to the concentration where the particular inhibitor would occupy 50% of the receptors if no 25 competing ligand (e.g. a radioligand) was present. Ki values can be converted logarithmically to pKi values (-log Ki), in which higher values indicate exponentially greater potency. "Therapeutically effective amount" means an amount of a compound that, when administered to a subject for treating a disease state, is sufficient to effect such treatment for the disease state. The "therapeutically effective amount" will vary depending on the compound, 30 disease state being treated, the severity or the disease treated, the age and relative health of the subject, the route and form of administration, the judgment of the attending medical or veterinary practitioner, and other factors. The term "as defined herein" and "as described herein" when referring to a variable incorporates by reference the broad definition of the variable as well as preferred, more preferred 35 and most preferred definitions, if any.

14 The term "tetrahydrofuranyl-C1_salkyl" alone or in combination with other groups, means a tetrahydrofuranyl linked via an alkyl as defined herein. The term "tetrahydropuranyl-C1- 6 alkyl" alone or in combination with other groups, means a tetrahydropuranyl linked via an alkyl as defined herein. 5 The term "oxetanyl-CI- 6 alkyl" alone or in combination with other groups, means a oxetanyl linked via an alkyl as defined herein. "Therapeutically effective amount" means an amount of a compound that, when administered to a subject for treating a disease state, is sufficient to effect such treatment for the disease state. The "therapeutically effective amount" will vary depending on the compound, 10 disease state being treated, the severity or the disease treated, the age and relative health of the subject, the route and form of administration, the judgment of the attending medical or veterinary practitioner, and other factors. The terms "those defined above" and "those defined herein" when referring to a variable incorporates by reference the broad definition of the variable as well as particular definitions, if 15 any. "Treating" or "treatment" of a disease state includes, inter alia, inhibiting the disease state, i.e., arresting the development of the disease state or its clinical symptoms, and/or relieving the disease state , i.e., causing temporary or permanent regression of the disease state or its clinical symptoms. 20 The terms "treating", "contacting" and "reacting" when referring to a chemical reaction means adding or mixing two or more reagents under appropriate conditions to produce the indicated and/or the desired product. It should be appreciated that the reaction which produces the indicated and/or the desired product may not necessarily result directly from the combination of two reagents which were initially added, i.e., there may be one or more intermediates which 25 are produced in the mixture which ultimately leads to the formation of the indicated and/or the desired product. Nomenclature and Structures In general, the nomenclature and chemical names used in this Application are based on ChembioOfficeTM by CambridgeSoftTM. Any open valency appearing on a carbon, oxygen 30 sulfur or nitrogen atom in the structures herein indicates the presence of a hydrogen atom unless indicated otherwise. Where a nitrogen-containing heteroaryl ring is shown with an open valency on a nitrogen atom, and variables such as Ra, Rb or Re are shown on the heteroaryl ring, such variables may be bound or joined to the open valency nitrogen. Where a chiral center exists in a structure but no specific stereochemistry is shown for the chiral center, both enantiomers 35 associated with the chiral center are encompassed by the structure. Where a structure shown 15 herein may exist in multiple tautomeric forms, all such tautomers are encompassed by the structure. The atoms represented in the structures herein are intended to encompass all naturally occurring isotopes of such atoms. Thus, for example, the hydrogen atoms represented herein are meant to include deuterium and tritium, and the carbon atoms are meant to include C13 and C 14 5 isotopes. All patents and publications identified herein are incorporated herein by reference in their entirety. Compounds of the Invention The invention provides compounds of the formula I: R 5 X R1 R 2 N N N H (R 7 )m 10 R 3 or pharmaceutically acceptable salts thereof, wherein: m is from 0 to 3; X is: -NRa-; -0-; or -S(O)r- wherein r is from 0 to 2 and Ra is hydrogen or C1_ 6 alkyl; 15 RI is: C1_ 6 alkyl; C 2

_

6 alkenyl; C 2

_

6 alkynyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy-C1_ 6 alkyl; hydroxy

C

2

-

6 alkenyl; amino-C1- 6 alkyl; C1- 6 alkylsulfonyl-CI_ 6 alkyl; C 3

_

6 cycloalkyl optionally substituted with C1- 6 alkyl; C 3

_

6 cycloalkyl-CI- 6 alkyl wherein the C3- 6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; tetrahydropuranyl; tetrahydropuranyl-C1_ 6 alkyl,oxetanyl; or oxetan-C1_ 6 alkyl; 20 or RI and Ra together with the atoms to which they are attached may form a three to six membered ring that may optionally include an additional heteroatom selected from 0, N and S, and which is substituted with oxo, halo or C1_ 6 alkyl; R2 is: halo; C1_salkoxy; cyano; C 2

-

6 alkynyl; C 2

-

6 alkenyl; halo-CI- 6 alkyl; halo-CI- 6 alkoxy;

C

3

_

6 cycloalkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl; C 3 _ 25 6 cycloalkyl-CI- 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1- 6 alkyl; acetyl; oxetanyl; or oxetan-C1- 6 alkyl; 16 R3 is: -OR 4 ; halo; cyano; C1_ 6 alkyl; halo-C1_ 6 alkyl; C 3

_

6 cycloalkyl optionally substituted with CI- 6 alkyl; C 3

_

6 cycloalkyl-Ci- 6 alkyl wherein the C3- 6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-CI_ 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; 5 R4 is: hydrogen, C1 6 alkyl; halo-C1.

6 alkyl; Ci- 6 alkoxy-Cialkyl; C 3

_

6 cycloalkyl optionally substituted with Ci- 6 alkyl or halo; C 3

-

6 cycloalkyl-CI- 6 alkyl wherein the C 3

-

6 cycloalkyl portion is optionally substituted with Ci- 6 alkyl or halo; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; oxetanyl; or oxetan-Ci- 6 alkyl;

R

5 is: hydrogen; or CI- 6 alkyl; 10 n is 0 or 1; R6 is: hydrogen; CI_ 6 alkyl; C1_ 6 alkoxy-C1_ 6 alkyl; hydroxy-C1_ 6 alkyl; amino-Ci- 6 alkyl; C 3 _ 6cycloalkyl; C 3

-

6 cycloalkyl-C1- 6 alkyl; heterocyclyl; or heterocyclyl-CI_ 6 alkyl; wherein the C 3 _ 6 cycloalkyl, C 3

-

6 cycloalkyl-CI- 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be optionally substituted with one, two, three or four groups groups independently selected from: 15 Ci- 6 alkyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy; halo-C1_ 6 alkoxy; hydroxy; hydroxy-C1_6alkyl; halo; nitrile; C1- 6 alkyl-carbonyl; Ci- 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C3- 6 cycloalkyl-CI- 6 alkyl; C 3

_

6 cycloalkyl carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; or R 5 and R 6 together with the nitrogen atom to which they are attached form a three- to 20 seven-membered ring that optionally includes an additional heteroatom selected from 0, N and S(O), and which is optionally substituted with one, two, three or four groups independently selected from: Ci- 6 alkyl; halo-CI_ 6 alkyl; CI_ 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI 6 alkyl; halo, nitrile; CI 6 alkyl-carbonyl; CI 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3

_

6 cycloalkyl-C1_ 6 alkyl; C 3 _ 6 cycloalkyl-carbonyl; amino; Clp 6 alkyl-heterocyclyl, C1- 6 alkoxy-C1- 6 alkyl or heterocyclyl; or two 25 of the groups together with the atoms to which they are attached may form a five or six membered ring; and R7 is: halo; CI 6 alkyl; CI- 6 alkoxy; halo-CI 6 alkyl; or halo-Ci- 6 alkoxy. The invention provides compounds of the formula I or pharmaceutically acceptable salts thereof, wherein: 30 m is 0 or 1, X is: -NRa-or -0-, wherein Ra is hydrogen;

R

1 is: Ci- 6 alkyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-Ci- 6 alkyl; C1- 6 alkylsulfonyl-Ci- 6 alkyl; C 3 _ 6 cycloalkyl optionally substituted with Ci- 6 alkyl; C 3

-

6 cycloalkyl-Ci- 6 alkyl wherein the C 3

_

17 6 cycloalkyl portion is optionally substituted with tetrahydrofuranyl; tetrahydrofuranyl-C p6alkyl; tetrahydropuranyl; tetrahydropuranyl-Ci- 6 alkyl; or RI and Ra together with the atoms to which they are attached may form a three to six membered ring that may optionally include an additional heteroatom selected from 0 and N; 5 R 2 is: halo; CI 6 alkoxy; cyano; CI 6 alkynyl; halo-CI- 6 alkyl; C 3

-

6 cycloalkyl; C 3

_

6 cycloalkyl Ci- 6 alkyl wherein the C3_ 6 cycloalkyl portion is optionally substituted with acetyl; R3 is: -OR 4 ; halo; CI 6 alkyl; C 3

-

6 cycloalkyl R4 is: hydrogen, C1_ 6 alkyl; halo-CI 6 alkyl; C 3

_

6 cycloalkyl optionally substituted with C,_ 6 cycloalkyl-C1- 6 alkyl 10 R5 is: hydrogen or Ci- 6 alkyl; n is 0 or 1; R6 is: hydrogen; Ci- 6 alkyl; C Isalkoxy-C1- 6 alkyl; hydroxy-CI 6 alkyl; amino-C I 6 alkyl; C 3 _ 6 cycloalkyl; C 3

-

6 cycloalkyl-Cp 6 alkyl; heterocyclyl; or heterocyclyl-C1_ 6 alkyl; wherein the C 3 _ 6 cycloalkyl, C 3

-

6 cycloalkyl-CI 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be 15 optionally substituted with one, two, three or four groups groups independently selected from: C1- 6 alkyl; halo and nitrile; or R 5 and R6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that optionally includes an additional heteroatom selected from 0 and N, and which is optionally substituted with one, two, three or four groups independently selected 20 from: CI- 6 alkyl; halo-C 1

_

6 alkyl; Ci- 6 alkoxy; hydroxy; hydroxy-Ci- 6 alkyl; halo, nitrile; CI 6 alkyl carbonyl; Ci- 6 alkyl-sulfonyl; C 3

-

6 cycloalkyl; C 3

-

6 cycloalkyl-carbonyl; Ci- 6 alkyl-heterocyclyl, C 1 6 alkoxy-Cp 6 alkyl, heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; and R is: halo or C 1

_

6 alkoxy. 25 The invention provides compounds of the formula I or pharmaceutically acceptable salts thereof, wherein: m is 0 or 1, X is -NH-or -0-, RI is Cp 6 alkyl; 30 R2 is halo; cyano or halo-Ci- 6 alkyl; R3 is -OR 4 or halo; R4 isCI- 6 alkyl; R5 is: hydrogen; n is 0; 18 R6 is Cp 6 alkyl; or R 5 and R6 together with the nitrogen atom to which they are attached form a morpholino ring; and R7 is halo or CI 6 alkoxy. 5 The invention provides compounds of the formula I or pharmaceutically acceptable salts thereof, wherein: m is 0 or 1, X is -NH-or -0-,

R

1 is methyl or ethyl; 10 R2 is Cl, CN or trifluoromethyl; R3 is Cl, methoxy, ethoxy or isopropoxy; R5 is: hydrogen; n is 0; R6 is tert-butyl; 15 or R and R6 together with the nitrogen atom to which they are attached form a morpholino ring; and R7 is F or methoxy.. The invention provides further compounds of the formula I: R xN 0 R 2 N N N 7) H (R3 )m 20 or pharmaceutically acceptable salts thereof, wherein: m is from 0 to 3; X is: -NRa-; -0-; or -S(0),- wherein r is from 0 to 2 and Ra is hydrogen or C 1

-

6 alkyl; RI is: C 6 alkyl; C 2

_

6 alkenyl; C 2

_

6 alkynyl; halo-C 6 alkyl; CI 6 alkoxy-C 6 alkyl; hydroxy 25 C 2

-

6 alkenyl; amino-C 1

_

6 alkyl; C 1

_

6 alkylsulfonyl-C 1

_

6 alkyl; C 3

-

6 cycloalkyl optionally substituted with CI- 6 alkyl; C 3

_

6 cycloalkyl-C 1

-

6 alkyl wherein the C 3

-

6 cycloalkyl portion is optionally 19 substituted with CI_ 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; or R 1 and Ra together with the atoms to which they are attached may form a three to six membered ring that may optionally include an additional heteroatom selected from 0, N and S, 5 and which is substituted with oxo, halo or C1_ 6 alkyl; R2 is: halo; C1_6alkoxy; cyano; C 2

_

6 alkynyl; C 2

_

6 alkenyl; halo-C1_ 6 alkyl; halo-CI_ 6 alkoxy;

C

3

-

6 cycloalkyl wherein the C 3

-

_

6 cycloalkyl portion is optionally substituted with Ci- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; acetyl; oxetanyl; or oxetan-Ci- 6 alkyl; 10 R3 is: -OR 4 ; halo; cyano; C1_ 6 alkyl; halo-C1_ 6 alkyl; C 3

_

6 cycloalkyl optionally substituted with Ci_ 6 alkyl; C 3

_

6 cycloalkyl-C1_ 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; R4 is: Ci- 6 alkyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-CI 6 alkyl; C 3

-

6 cycloalkyl optionally substituted 15 with C1_ 6 alkyl or halo; C 3

_

6 cycloalkyl-C1_ 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with CI 6 alkyl or halo; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; oxetanyl; or oxetan-Ci- 6 alkyl;

R

5 is: hydrogen; or CI- 6 alkyl; n is 0 or 1; 20 R 6 is: hydrogen; C1- 6 alkyl; C1- 6 alkoxy-CI_ 6 alkyl; hydroxy-Ci- 6 alkyl; amino-C1- 6 alkyl; C 3 _ 6 Cycloalkyl; C 3

-

6 cycloalkyl-C1- 6 alkyl; heterocyclyl; or heterocyclyl-C1_ 6 alkyl; wherein the C 3 _ 6cycloalkyl, C 3

-

6 cycloalkyl-CI- 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be optionally substituted with one, two, three or four groups groups independently selected from: C1- 6 alkyl; halo-CI_ 6 alkyl; CI_ 6 alkoxy; halo-Ci- 6 alkoxy; hydroxy; hydroxy-Ci-salkyl; halo; nitrile; 25 C1- 6 alkyl-carbonyl; C1_ 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C3_ 6 cycloalkyl-C1_ 6 alkyl; C 3

_

6 cycloalkyl carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; or R' and R 6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that optionally includes an additional heteroatom selected from 0, N and 30 S(O), and which is optionally substituted with one, two, three or four groups independently selected from: Ci- 6 alkyl; halo-CI_ 6 alkyl; CI_ 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI 6 alkyl; halo, nitrile; CI_ 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3

-

6 cycloalkyl-C1- 6 alkyl; C 3 _ 6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; and 20 R7 is: halo; C1_ 6 alkyl; Ci 6 alkoxy; halo-C1_ 6 alkyl; or halo-C1_ 6 alkoxy. In certain embodiments of formula I, n is 0. In certain embodiments of formula I, n is 1. In certain embodiments of formula I, R 1 and Ra together with the atoms to which they are 5 attached may form a three to six membered ring that may optionally include an additional heteroatom selected from 0, N and S, and which may be optionally substituted with oxo, halo or Ci- 6 alkyl. In certain embodiments of formula I, RI and Ra together with the atoms to which they are attached form a five or six membered ring. 10 In certain embodiments of formula I, R 1 and Ra together with the atoms to which they are attached form a pyrolidinyl, piperidinyl or oxazoladinonyl group. In certain embodiments of formula I, R 2 is acetyl. In certain embodiments the subject compounds are of formula II: R 2 (R 7m 5 N N H R 3 15 or pharmaceutically acceptable salts thereof, wherein X, m, R1, R2, R', R 5 and R 7 are as defined in formula I. In certain embodiments the subject compounds are of formula II: R N N RR 2 (R )m SNN N N H

R

3 or pharmaceutically acceptable salts thereof, 20 wherein: 21 m is from 0 to 3; X is: -NRa-; -0-; or -S(O)r- wherein r is from 0 to 2 and Ra is hydrogen or CI- 6 alkyl; RI is: C1- 6 alkyl; C 2

-

6 alkenyl; C 2

-

6 alkynyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-Ci- 6 alkyl; hydroxy

C

2

-

6 alkenyl; amino-Ci- 6 alkyl; Ci- 6 alkylsulfonyl-CI_ 6 alkyl; C 3

_

6 cycloalkyl optionally substituted 5 with CI- 6 alkyl; C 3

_

6 cycloalkyl-Ci- 6 alkyl wherein the C3- 6 cycloalkyl portion is optionally substituted with CI_ 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; oxetanyl; or oxetan-C 6 alkyl; R2 is: halo; Ci-salkoxy; cyano; C 2

-

6 alkynyl; C 2

-

6 alkenyl; halo-Ci- 6 alkyl; halo-CI- 6 alkoxy;

C

3

-

6 cycloalkyl wherein the C 3

-

6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; C 3 _ 10 6 cycloalkyl-C1_ 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; oxetanyl; or oxetan-C1_ 6 alkyl; R3 is: -OR 4 ; halo; cyano; C 3

-

6 cycloalkyl optionally substituted with Ci- 6 alkyl; C 3 _ 6 cycloalkyl-CI- 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with CI- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; oxetanyl; or oxetan-Ci- 6 alkyl; 15 R4 is: C 1 6 alkyl; halo-C 1

-

6 alkyl; C 1 6 alkoxy-C _6alkyl; C 3

-

6 cycloalkyl optionally substituted with Ci- 6 alkyl; C 3

_

6 cycloalkyl-C1_ 6 alkyl wherein the C3_ 6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-CI_ 6 alkyl; oxetanyl; or oxetan-C 6 alkyl; R5 is: hydrogen; or CI- 6 alkyl; 20 R 6 is: hydrogen; Ci- 6 alkyl; CI- 6 alkoxy-Ci- 6 alkyl; amino-CI- 6 alkyl; C 3

_

6 cycloalkyl; C 3 _ 6 Cycloalkyl-C1- 6 alkyl; heterocyclyl; or heterocyclyl-C1_ 6 atkyl; wherein the C 3

_

6 cycloalkyl, C 3 _ 6 cycloalkyl-CI- 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be optionally substituted with one, two or three groups independently selected from: Ci- 6 alkyl; halo-Ci- 6 alkyl; CI- 6 alkoxy; halo-C I 6 alkoxy; hydroxy; hydroxy-CI_ 6 alkyl; halo; nitrile; CI_ 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl; 25 C 3

-

6 cycloalkyl; C 3

_

6 cycloalkyl-C1_ 6 alkyl; C 3

_

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six membered ring; or R5 and R6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that optionally includes an additional heteroatom selected from 0, N and 30 S(O), and which is optionally substituted with one, two or three groups independently selected from: Ci- 6 alkyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy; halo-CI- 6 alkoxy; hydroxy; hydroxy-CI- 6 alkyl; halo, nitrile; CI 6 alkyl-carbonyl; CI_ 6 alkyl-sulfonyl; C 3

-

6 cycloalkyl; C 3

_

6 cycloalkyl-C I 6 alkyl; C 3 _ 6cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; and 22 R7 is: halo; C1_ 6 alkyl; Ci_ 6 alkoxy; halo-C1_ 6 alkyl; or halo-C1_ 6 alkoxy. In certain embodiments of formula I, when RI is C 3

-

6 cycloalkyl or C 3

-

6 cycloalkyl-C1_ 6 alkyl, then X is -0-. In certain embodiments of formula I, when R 1 is cyclopropyl, cyclobutyl, cyclopropyl-C1_ 5 6 alkyl or cyclobutyl-CI- 6 alkyl, then X is -0-. In certain embodiments of formula I or formula II, m is from 0 to 2. In certain embodiments of formula I or formula II, m is 0 or 1. In certain embodiments of formula I or formula II, m is 0. In certain embodiments of formula I or formula II, m is 1. 10 In certain embodiments of formula I or formula II, r is 0. In certain embodiments of formula I or formula II, r is 2. In certain embodiments of formula I or formula II, X is -NRa-or -0-. In certain embodiments of formula I or formula II, X is -NRa In certain embodiments of formula I or formula II, X is -0-. 15 In certain embodiments of formula I or formula II, X is -S(O)-. In certain embodiments of formula I or formula II, X is -NH-or -0-. In certain embodiments of formula I or formula II, Ra is hydrogen. In certain embodiments of formula I or formula II, Ra is C1 6 alkyl. In certain embodiments of formula I or formula II, R is: C1 6 alkyl; halo-C1 6 alkyl; C 1 20 6 alkoxy-Ci- 6 alkyl; amino-CI_ 6 alkyl; CI_ 6 alkylsulfonyl-C1- 6 alkyl; C 3

-

6 cycloalkyl; or C3_ 6 cycloalkyl-C1- 6 alkyl. In certain embodiments of formula I or formula II, R 1 is: CI 6 alkyl; C 3

-

6 cycloalkyl optionally substituted with C1_ 6 alkyl; or C3_ 6 cycloalkyl-C1_ 6 alkyl wherein the C3_ 6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl. 25 In certain embodiments of formula I or formula II, RI is: CI- 6 alkyl; halo-CI- 6 alkyl; C 1 _ 6 alkoxy-C1-6alkyl; amino-C1- 6 alkyl; C1- 6 alkylsulfonyl-C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1- 6 alkyl; oxetanyl; or oxetan-CI_ 6 alkyl.

23 In certain embodiments of formula I or formula II, RI is: C1_ 6 alkyl; halo-C1_ 6 alkyl; C 1 _ 6 alkoxy-C1- 6 alkyl; amino-C1- 6 alkyl; or C1- 6 alkylsulfonyl-C1- 6 alkyl. In certain embodiments of formula I or formula II, R 1 is C1- 6 alkyl. In certain embodiments of formula I or formula II, R 1 is halo-CI- 6 alkyl. 5 In certain embodiments of formula I or formula II, R 1 is CI- 6 alkoxy-CI- 6 alkyl. In certain embodiments of formula I or formula II, R 1 is amino-CI- 6 alkyl. In certain embodiments of formula I or formula II, R 1 is C1- 6 alkylsulfonyl-C1_ 6 alkyl optionally substituted with Ci_ 6 alkyl. In certain embodiments of formula I or formula II, RI is C 3

-

6 cycloalkyl optionally 10 substituted with C1- 6 alkyl. In certain embodiments of formula I or formula II, R 1 is C 3

-

6 cycloalkyl-Ci- 6 alkyl wherein the C 3

-

6 cycloalkyl portion is optionally substituted with C1- 6 alkyl. In certain embodiments of formula I or formula II, R 1 is tetrahydrofuranyl. In certain embodiments of formula I or formula II, R 1 is tetrahydrofuranyl-CI 6 alkyl; 15 oxetanyl. In certain embodiments of formula I or formula II, R 1 is or oxetan-CI 6 alkyl. In certain embodiments of formula I or formula II, R 1 is: methyl; ethyl; n-propyl; isopropyl; isobutyl; 3,3-dimethylpropyl; cyclopropyl; cyclobutyl; cyclopentyl; cyclohexyl; cyclopropylmethyl; cyclobutylmethyl; cyclopentylmethyl; cyclopropylethyl; methoxyethyl; 20 oxetanyl; or tetrahydrofuranylmethyl. In certain embodiments of formula I or formula II, R 1 is: methyl; ethyl; n-propyl; isopropyl; isobutyl; 3,3-dimethylpropyl; cyclopentyl; cyclohexyl; cyclopropylmethyl; cyclobutylmethyl; cyclopentylmethyl; cyclopropylethyl; methoxyethyl; oxetanyl; or tetrahydrofuranylmethyl. 25 In certain embodiments of formula I or formula II, R 1 is: methyl; ethyl; n-propyl; isopropyl; isobutyl; 3,3-dimethylpropyl; cyclopentyl; cyclohexyl; cyclopentylmethyl; methoxyethyl; oxetanyl; or tetrahydrofuranylmethyl. In certain embodiments of formula I or formula II, R 1 is: methyl; ethyl; n-propyl; isopropyl; or isobutyl. 30 In certain embodiments of formula I or formula II, R' is methyl or ethyl.

24 In certain embodiments of formula I or formula II, R 1 is methyl. In certain embodiments of formula I or formula II, R 1 is ethyl. In certain embodiments of formula I or formula II, R 1 is: cyclopropyl; cyclobutyl; cyclopentyl; cyclohexyl; cyclopropylmethyl; cyclobutylmethyl; cyclopentylmethyl; or 5 cyclopropylethyl. In certain embodiments of formula I or formula II, R 1 is: cyclopentyl; cyclohexyl; or cyclopentylmethyl. In certain embodiments of formula I or formula II, R 2 is: halo; Ci- 6 alkoxy; halo-Ci- 6 alkyl; halo-CI 6 alkoxy; C 3

_

6 cycloalkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with 10 C1- 6 alkyl; C 3

-

6 cycloalkyl-CI 6 alkyl wherein the C 3

_

6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; oxetanyl; or oxetan-C1_ 6 alkyl. In certain embodiments of formula I or formula II, R 2 is: halo; C1_ 6 alkoxy; halo-C1_ 6 alkyl; cyano; C 2 -salkynyl; C 2

-

6 alkenyl; C 3

-

6 cycloalkyl; or C 3

_

6 cycloalkyl-CI_ 6 alkyl. In certain embodiments of formula I or formula II, R 2 is: halo; Ci- 6 alkoxy; halo-Ci- 6 alkyl; 15 cyano; C 3 -6cycloalkyl; or C 3

_

6 cycloalkyl-CI 6 alkyl. In certain embodiments of formula I or formula II, R2 is: halo; Ci- 6 alkoxy; halo-Ci- 6 alkyl;

C

3

_

6 cycloalkyl; or C 3

_

6 cycloalkyl-C1_ 6 alkyl. In certain embodiments of formula I or formula II, R 2 is: halo; halo-C1_ 6 alkyl; or cyano. In certain embodiments of formula I or formula II, R 2 is: halo; or halo-C1_ 6 alkyl. 20 In certain embodiments of formula I or formula II, R 2 is halo. In certain embodiments of formula I or formula II, R 2 is Ci- 6 alkoxy. In certain embodiments of formula I or formula II, R 2 is halo-C1- 6 alkoxy. In certain embodiments of formula I or formula II, R 2 is halo-C1- 6 alkyl. In certain embodiments of formula I or formula II, R 2 is C 3

-

6 cycloalkyl. 25 In certain embodiments of formula I or formula II, R 2 is C 3

-

6 cycloalkyl-Ci- 6 alkyl. In certain embodiments of formula I or formula II, R 2 is tetrahydrofuranyl. In certain embodiments of formula I or formula II, R 2 is tetrahydrofuranyl-C1_ 6 alkyl. In certain embodiments of formula I or formula II, R 2 is oxetanyl.

25 In certain embodiments of formula I or formula II, R 2 is oxetan-Ci_ 6 alkyl. In certain embodiments of formula I or formula II, R 2 is halo, trifluoromethyl or cyano. In certain embodiments of formula I or formula II, R2 is chloro, trifluoromethyl or cyano. In certain embodiments of formula I or formula II, R2 is fluoro, chloro or bromo. 5 In certain embodiments of formula I or formula II, R 2 is chloro. In certain embodiments of formula I or formula II, R 2 is fluoro. In certain embodiments of formula I or formula II, R 2 is bromo. In certain embodiments of formula I or formula II, R 2 is trifluoromethyl. In certain embodiments of formula I or formula II, R 2 is methoxy. 10 In certain embodiments of formula I or formula II, R 2 is cyano. In certain embodiments of formula I or formula II, R2 is C2_6alkynyl. In certain embodiments of formula I or formula II, R2 is C26alkenyl. 2 4 In certain embodiments of formula I or formula II, R' is C1-alkyl . In certain embodiments of formula I or formula II, R3 is: C 6 alkyl; or . 15 ~In certain embodiments of formula I or formula 11, R3 is: -a;or. -R In certain embodiments of formula I or formula II, R3 is: halo; C1-alkoxy; halo-C 6alkOXy; C3-6cyclOalkylOXy; oT C3-6cycloalkyl-CI-6alkylOXy. In certain embodiments of formula I or formula II, R3 is: C-6alkoxy; halo-C_6alkoxy;C3_ 6CycalkyOcyloalkyloxy; orC3-6CyC ylalkyl-C ialkyOXy. 20 In certain embodiments of formula I or formula II, R 3 is: halo; C1- 6 alkoxy; cyano; or halo-C1_6alkoxy. In certain embodiments of formula I or formula II, R 3 is: halo; C1_ 6 alkoxy; or halo-C1_ alO 6 alkoxy. In certain embodiments of formula I or formula II, R 3 is: methoxy; halo; 25 trifluoromethoxy; difluoromethoxy; 2-halo-ethoxy or 2,2,2-trihaloethoxy. In certain embodiments of formula I or formula II, R 3 is: methoxy; or halo.

26 In certain embodiments of formula I or formula II, R 3 is: methoxy; chloro; or fluoro. In certain embodiments of formula I or formula II, R 3 is methoxy. In certain embodiments of formula I or formula II, R 3 is chloro. In certain embodiments of formula I or formula II, R 3 is fluoro. 5 In certain embodiments of formula I or formula II, R3 is: Ci- 6 alkoxy; cyano; or halo-C 1 _ 6 alkoxy. In certain embodiments of formula I or formula II, R3 is: Ci- 6 alkoxy; or halo-CI 6 alkoxy. In certain embodiments of formula I or formula II, R 3 is C1_ 6 alkoxy. In certain embodiments of formula I or formula II, R 3 is methoxy. 10 In certain embodiments of formula I or formula II, R 3 is cyano. In certain embodiments of formula I or formula II, R3 is C 3

-

6 cycloalkyl. In certain embodiments of formula I or formula II, R 3 is C 3

-

6 cycloalkyl-CI- 6 alkyl. In certain embodiments of formula I or formula II, R- is tetrahydrofuranyl. In certain embodiments of formula I or formula II, R3 is tetrahydrofuranyl-Ci- 6 alkyl. 15 In certain embodiments of formula I or formula II, R 3 is oxetanyl. In certain embodiments of formula I or formula II, R 3 is oxetan-Ci- 6 alkyl. In certain embodiments of formula I or formula II, R 4 is: CI_ 6 alkyl; halo-C1_ 6 alkyl; C 1 _ 6 alkoxy-C1- 6 alkyl; C 3

-

6 cycloalkyl; or C 3

-

6 cycloalkyl-C1- 6 alkyl. In certain embodiments of formula I or formula II, R4 is: C1_ 6 alkyl; halo-Ci- 6 alkyl; orC3_ 20 6 cycloalkyl. In certain embodiments of formula I or formula II, R 4 is Ci- 6 alkyl. In certain embodiments of formula I or formula II, R 4 is halo-CI- 6 alkyl. In certain embodiments of formula I or formula II, R 4 is Ci- 6 alkoxy-CI- 6 alkyl. In certain embodiments of formula I or formula II, R 4 is C 3

-

6 cycloalkyl. 25 In certain embodiments of formula I or formula II, R 4 is C3- 6 cycloalkyl-C1_ 6 alkyl. In certain embodiments of formula I or formula II, R 4 is tetrahydrofuranyl.

27 In certain embodiments of formula I or formula II, R 4 is tetrahydrofuranyl-C1_ 6 alkyl. In certain embodiments of formula I or formula II, R 4 is oxetanyl. In certain embodiments of formula I or formula II, R 4 is or oxetan-CI 6 alkyl. In certain embodiments of formula I or formula II, R4 is: methyl; ethyl; isopropyl; 5 cyclopropyl; cyclobutyl; cyclopropylmethyl; cyclobutylmethyl; 2-haloethyl; or 2,2,2-trihaloethyl. In certain embodiments of formula I or formula II, R 4 is methyl. In certain embodiments of formula I or formula II, R 5 is hydrogen. In certain embodiments of formula I or formula II, R 5 is C1_ 6 alkyl. In certain embodiments of formula I or formula II, R 5 is methyl. 10 In certain embodiments of formula I or formula II, R 5 is ethyl. In certain embodiments of formula I or formula II, R 6 is hydrogen. In certain embodiments of formula I or formula II, R 6 is C1-6alkyl. In certain embodiments of formula I or formula II, R is CI- 6 alkoxy-C1-alkyl. In certain embodiments of formula I or formula II, R 6 is hydroxy-CI-alkyl. 15 In certain embodiments of formula I or formula II, R 6 is amino-CI- 6 alkyl. In certain embodiments of formula I or formula II, R6 is C3-cycloalkyl optionally substituted with one, two or three groups independently selected from: CI6alkyl; halo-CI 6 alkyl; Ci_ 6 alkoxy; halo-C1_ 6 alkoxy; hydroxy; hydroxy-C1_ 6 alkyl; halo; nitrile; C1_ 6 alkyl-carbonyl; C 1 _ 6 alkyl-sulfonyl; C 3

-

6 cycloalkyl; C 3

-

6 cyclOalkyl-C1- 6 alkyl; C 3

-

6 cycloalkyl-carbonyl; amino; or 20 heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring. In certain embodiments of formula I or formula II, R6 is C 3

-

6 cycloalkyl-Ci_ 6 alkyl wherein the C 3

_

6 cycloalkyl portion thereof is optionally substituted with one, two or three groups independently selected from: CI- 6 alkyl; halo-CI- 6 alkyl; CI- 6 alkoxy; halo-CI- 6 alkoxy; hydroxy; 25 hydroxy-C1- 6 alkyl; halo; nitrile; CI 6 alkyl-carbonyl; CI 6 alkyl-sulfonyl; C 3

-

6 cycloalkyl; C 3 _ 6 CyCloalkyl-C1- 6 alkyl; C 3

-

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring. In embodiments of formula I or formula II wherein R6 is heterocyclyl, such heterocycle may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; morpholinyl; thiomorpholinyl; 3-oxa- 28 8-aza-bicyclo[3.2.1 ]oct-8-yl; 2-oxa-5-aza-bicyclo[2.2.1 ]hept-5-yl; or 8-oxa-3-aza bicyclo[3.2.1]oct-3-yl; each optionally substituted as defined herein. In embodiments of formula I or formula II wherein R 6 is heterocyclyl, such heterocycle may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; or morpholinyl; each optionally 5 substituted as defined herein, i.e., such heterocycyl is optionally substituted with one, two or three groups independently selected from: C1- 6 alkyl; halo-CI- 6 alkyl; CI- 6 alkoxy; halo-CI- 6 alkoxy; hydroxy; hydroxy-CI- 6 alkyl; halo; nitrile; CI_ 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl;

C

3

-

6 cycloalkyl-CI 6 alkyl; C 3

_

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring. 10 In certain embodiments of formula I or formula II, R6 is heterocyclyl optionally substituted with one, two or three groups independently selected from: C1_salkyl; halo-CI- 6 alkyl; C1- 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI_ 6 alkyl; halo; nitrile; CI_ 6 alkyl-carbonyl; C 1 _ 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3

_

6 cycloalkyl-C1_6alkyl; C 3

_

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a 15 five or six-membered ring. In embodiments of formula I or formula II wherein R6 is heterocyclyl-CI- 6 alkyl, the heterocyclyl portion thereof may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; morpholinyl; thiomorpholinyl; 3-oxa-8-aza-bicyclo[3.2.1 ]oct-8-yl; 2-oxa-5-aza bicyclo[2.2.1]hept-5-yl; or 8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl; each optionally substituted as 20 defined herein, i.e., such heterocycyl portion is optionally substituted with one, two or three groups independently selected from: CI_ 6 alkyl; halo-CI- 6 alkyl; CI_ 6 alkoxy; halo-C1- 6 alkoxy; hydroxy; hydroxy-C1_ 6 alkyl; halo; nitrile; C1_ 6 alkyl-carbonyl; C1.

6 alkyl-sulfonyl; C 3

_

6 cycloalkyl;

C

3

_

6 cycloalkyl-CI 6 alkyl; C 3

_

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring.. 25 In embodiments of formula I or formula II wherein R6 is heterocyclyl-CI- 6 alkyl, the heterocyclyl portion thereof may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; or morpholinyl; each optionally substituted as defined herein. In certain embodiments of formula I or formula II, R 6 is heterocyclyl-C1_ 6 alkyl wherein the heterocyclyl portion thereof is optionally substituted with one, two or three groups 30 independently selected from: CI- 6 alkyl; halo-CI- 6 alkyl; CI- 6 alkoxy; halo-CI- 6 alkoxy; hydroxy; hydroxy-C1_ 6 alkyl; halo; nitrile; C1_ 6 alkyl-carbonyl; C1_ 6 alkyl-sulfonyl; C3_ 6 cycloalkyl; C 3 _ 6 cycloalkyl-C1- 6 alkyl; C 3

-

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring. In certain embodiments of formula I or formula II, R6 is: hydrogen; methyl; ethyl; 35 isopropyl; or cyclopropyl.

29 In certain embodiments of formula I or formula II, R6 is: hydrogen; methyl; ethyl; isopropyl;2-amino-propyl; oxetan-3-yl; 2-methoxy-ethyl; 2-hydroxy-ethyl; cyclopropyl; piperidin-4-yl; 1-methyl-piperidin-4-yl; tert-butl; 2-hydroxy-2-methyl-propyl; cyclobutyl; 1 methyl-cyclobutyl; 2-hydroxy-propyl; 1-cyano-cyclopropyl; 3,3-difluoro-cyclobutyl; 5 cyclopropylmethyl; 3-fluoro-cyclobutyl; or 2,2-difluoroethyl; In certain embodiments of formula I or formula II, R 6 is hydrogen. In certain embodiments of formula I or formula II, R 6 is methyl. In certain embodiments of formula I or formula II, R is ethyl. In certain embodiments of formula I or formula II, R 6 is isopropyl. 10 In certain embodiments of formula I or formula II, R 6 is 2-amino-propyl. In certain embodiments of formula I or formula II, R 6 is oxetan-3-yl. In certain embodiments of formula I or formula II, R 6 is 2-methoxy-ethyl. In certain embodiments of formula I or formula II, R 6 is 2-hydroxy-ethyl. In certain embodiments of formula I or formula II, R 6 is cyclopropyl. 15 In certain embodiments of formula I or formula II, R6 is piperidin-4-yl. In certain embodiments of formula I or formula II, R 6 is o-methyl-piperidin-4-yl. In certain embodiments of formula I or formula II, R 6 is tert-butyl. In certain embodiments of formula I or formula II, R6 is 2-hydroxy-2-methyl-propyl. In certain embodiments of formula I or formula II, R is cyclobutyl. 0In certain embodiments of formula I or formula II, R is 1ethyl In certain embodiments of formula I or formula II, R 6 is 2-hydroxy-propyl-popy.. In certain embodiments of formula I or formula II, R 6 is 1-cy-cyclo propyl. In certain embodiments of formula I or formula II, R 6 is 3,-dihlo-cyclobutyl. In certain embodiments of formula I or formula II, R 6 is c-ydloropylotyl. In certain embodiments of formula I or formula II, R 6 is 3-cyano-cyclourtyl. In certain embodiments of formula I or formula II, R 6 is 3,2-difluoro-cyclobutyl. In certain embodiments of formula I or formula 11, R 6 is 2,2-difluoroethyl.

30 In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that is optionally includes an additional heteroatom selected from 0, N and S(O)n, and which is optionally substituted with one, two or three groups independently selected from Ci 6 alkyl, halo-C1_ 6 alkyl, C1_ 6 alkoxy, halo 5 Ci_ 6 alkoxy, hydroxy, hydroxy-C1_ 6 alkyl, halo, nitrile, C1_ 6 alkyl-carbonyl, C1_ 6 alkyl-sulfonyl, C 3 _ 6 cycloalkyl, C 3

-

6 cycloalkyl-CI- 6 alkyl, C 3

-

6 cycloalkyl-carbonyl, or heterocyclyl, or two of the groups together with the atoms to which they are attached may form a five or six-membered ring. In embodiments of formula I or formula II wherein R 5 and R6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that is optionally includes 10 an additional heteroatom selected from 0, N and S(O), such ring may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; morpholinyl; thiomorpholinyl; azepinyl; 3-oxa-8-aza bicyclo[3.2.1]oct-8-yl; 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl; or 8-oxa-3-aza-bicyclo[3.2.1]oct-3 yl; each optionally substituted as defined herein. In embodiments of formula I or formula II wherein R 5 and R6 together with the nitrogen 15 atom to which they are attached form a three- to seven-membered ring that is optionally includes an additional heteroatom selected from 0, N and S(O), such ring may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; or morpholinyl; each optionally substituted as defined herein. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 20 atom to which they are attached form a morpholinyl group that is optionally substituted once or twice with groups independently selected from Ci 6 alkyl, halo-Ci- 6 alkyl, Ci- 6 alkoxy, halo-C 1 _ 6 alkoxy, hydroxy, hydroxy-CI_ 6 alkyl, halo, nitrile, C 1.

6 alkyl-carbonyl, C 1 6 alkyl-sulfonyl, C 3 6 cycloalkyl, C 3

-

6 cycloalkyl-CI- 6 alkyl, C 3

-

6 cycloalkyl-carbonyl, amino, or heterocyclyl, or the two groups together with the atoms to which they are attached may form a five or six-membered ring. 25 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form a piperidinyl group that is optionally substituted once or twice with groups independently selected from Ci_ 6 alkyl, halo-C1_ 6 alkyl, C1_ 6 alkoxy, halo-C 1 _ 6 alkoxy, hydroxy, hydroxy-Ci- 6 alkyl, halo, nitrile, Ci- 6 alkyl-carbonyl, Ci- 6 alkyl-sulfonyl, C 3 _ 6 cycloalkyl, C 3

-

6 cycloalkyl-CI- 6 alkyl, C 3

-

6 cycloalkyl-carbonyl, amino, or heterocyclyl, or the two 30 groups together with the atoms to which they are attached may form a five or six-membered ring. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form a piperazinyl group that is optionally substituted once or twice with groups independently selected from CI- 6 alkyl, halo-Ci- 6 alkyl, Ci- 6 alkoxy, halo-C 1 _ 6 alkoxy, hydroxy, hydroxy-Ci- 6 alkyl, halo, nitrile, Ci- 6 alkyl-carbonyl, Ci- 6 alkyl-sulfonyl, C 3 _ 35 6cycloalkyl, C3_ 6 cycloalkyl-C1_ 6 alkyl, C 3

_

6 cycloalkyl-carbonyl, amino, or heterocyclyl, or the two groups together with the atoms to which they are attached may form a five or six-membered ring.

31 In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form a pyrrolidinyl group that is optionally substituted once or twice with groups independently selected from Ci 6 alkyl, halo-C 1 -alkyl, C 16 -alkoxy, halo-C1_ 6 alkoxy, hydroxy, hydroxy-C1_ 6 alkyl, halo, nitrile, C1_ 6 alkyl-carbonyl, C1_ 6 alkyl-sulfonyl, C 3 _ 5 6 cycloalkyl, C 3

_

6 cycloalkyl-C1_ 6 alkyl, C 3

_

6 cycloalkyl-carbonyl, amino, or heterocyclyl, or the two groups together with the atoms to which they are attached may form a five or six-membered ring. In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form a group selected from: morpholin-4-yl; 4-hydroxy piperidin-1-yl; octahydro-pyrido[1,2-a]pyrazin-2-yl; 2-hydroxy-piperidin-1-yl; 4,4-dimethyl 10 piperidin- 1 -yl; 3,5-dimethyl-piperidin- 1 -yl; 1 -hydroxy-1 -methyl-ethyl)-piperidin- 1 -yl; 3 hydroxy-pyrrolidin-1-yl; 4-methyl-piperidin-1-yl; piperidin-1-yl; azetidin-1-yl; 4,4-difluoro piperidin-1-yl; 3-methyl-piperidin-1-yl; 4-methoxy-piperidin-1-yl; 3,3-difluoro-piperidin-1-yl; 4 cyano-piperidin-1-yl; 4-fluoro-piperidin-1-yl; 3-methoxy-piperidin-1-yl; 4-ethyl-piperazin-1-yl; 4-acetyl-piperazin-1-yl; 3-trifluoromethyl-piperidin-1-yl; 4-tert-butyl-piperidin-1-yl; 2-hydroxy 15 ethyl)-piperazin-1-yl; 2-methyl-pyrrolidin-1-yl; 4-hydroxymethyl-piperidin- 1 -yl; 2-methyl piperidin-1-yl; pyrrolidin-1-yl; 4-methanesulfonyl-piperazin-1-yl; 3-trifluoromethyl-pyrrolidin 1-yl; 4-(2,2,2-trifluoro-ethyl)-piperazin- 1 -yl; 2-methyl-morpholin-4-yl; (2,6-dimethyl morpholin-4-yl; 2,2-diethyl-morpholin-4-yl; 3-hydroxymethyl-morpholin-4-yl; 2-isobutyl morpholin-4-yl; 2-hydroxymethyl-morpholin-4-yl; 3,3-dimethyl-morpholin-4-yl; 4-methyl 20 piperazin-1-yl; 4-isopropyl-piperazin-1-yl; piperazin-1-yl; 3-oxa-8-aza-bicyclo[3.2.1]oct-8-yl; (S)-3-methyl-morpholin-4-yl; 2-oxa-5-aza-bicyclo[2.2.1 ]hept-5-yl; 8-oxa-3-aza bicyclo[3.2.1]oct-3-yl; (R)-3-methyl-morpholin-4-yl; 4-cyclopropanecarbonyl-piperazin-1-yl; 4 (1 -hydroxy- 1 -methyl-ethyl)-piperidin- 1 -yl; 4-cyclobutyl-piperazin- 1 -yl; (R)-3-hydroxy pyrrolidin-1-yl; 4-oxetan-3-yl-piperazin-1-yl; 3-morpholin-4-yl-azetidin-1-yl; 4-(1-methyl 25 piperidin-4-yl)-piperazin-1-yl; 3,3-difluoro-azetidin-1-yl; 4-dimethylamino-piperidin-1-yl; 4 piperidin-4-yl-piperazin-1-yl; (4,4-difluoro-piperidin-1-yl; (3-morpholin-4-yl-azetidin-1-yl; 2 oxa-6-aza-spiro[3.3]hept-6-yl; 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl); 4-methoxy-piperidin-1-yl); [1,4]oxazepan-4-yl; 2R,6S)-2,6-dimethyl-morpholin-4-yl; 3-hydroxy-azetidin-1-yl; 3-cyano pyrrolidin- 1 -yl; 3,5 -dimethyl-piperazin- 1 -yl; (3R,5 S)-dimethyl-piperazin- 1 -yl; 3-Fluoro 30 pyrrolidin-1-yl; (S)-3-Fluoro-pyrrolidin-1-yl; piperazin-1-yl; 3,3-Difluoro-pyrrolidin-1-yl; 3,3 Difluoro-azetidin-1-yl; 2,2,6,6-tetrafluoro-morpholin-4-yl; 2-methoxymethyl-pyrrolidin-1-yl; (S)-2-methoxymethyl-pyrrolidin-1-yl; (iS,4S)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-yl; (3S,4S) 3,4-difluoropyrrolidin-1-yl; 3,4-difluoropyrrolidin-1-yl; and 3-methoxypyrrolidin-1-yl. In certain embodiments of formula I or formula II, R5 and R6 together with the nitrogen 35 atom to which they are attached form a group selected from: morpholin-4-yl; 4-hydroxy piperidin-1-yl; octahydro-pyrido[1,2-a]pyrazin-2-yl; 2-hydroxy-piperidin-1-yl; 4,4-dimethyl piperidin- 1 -yl; 3,5-dimethyl-piperidin- 1 -yl; 1 -hydroxy-1 -methyl-ethyl)-piperidin- 1 -yl; 3 hydroxy-pyrrolidin-1-yl; 4-methyl-piperidin-1-yl; piperidin-1-yl; azetidin-1-yl; 4,4-difluoro piperidin-1-yl; 3-methyl-piperidin-1-yl; 4-methoxy-piperidin-1-yl; 3,3-difluoro-piperidin-1-yl; 4- 32 cyano-piperidin-1-yl; 4-fluoro-piperidin-1-yl; 3-methoxy-piperidin-1-yl; 4-ethyl-piperazin-1-yl; 4-acetyl-piperazin-1-yl; 3-trifluoromethyl-piperidin-1-yl; 4-tert-butyl-piperidin-1-yl; 2-hydroxy ethyl)-piperazin-1-yl; 2-methyl-pyrrolidin-1-yl; 4-hydroxymethyl-piperidin-1-yl; 2-methyl piperidin-1-yl; pyrrolidin-1-yl; 4-methanesulfonyl-piperazin-1-yl; 3-trifluoromethyl-pyrrolidin 5 1-yl; 4-(2,2,2-trifluoro-ethyl)-piperazin- 1-yl; 2-methyl-morpholin-4-yl; (2,6-dimethyl morpholin-4-yl; 2,2-diethyl-morpholin-4-yl; 3-hydroxymethyl-morpholin-4-yl; 2-isobutyl morpholin-4-yl; 2-hydroxymethyl-morpholin-4-yl; 3,3-dimethyl-morpholin-4-yl; 4-methyl piperazin-1-yl; 4-isopropyl-piperazin-1-yl; piperazin-1-yl; 3-oxa-8-aza-bicyclo[3.2.1]oct-8-yl; (S)-3-methyl-morpholin-4-yl; 2-oxa-5 -aza-bicyclo [2.2.1 ]hept-5 -yl; 8-oxa-3-aza 10 bicyclo[3.2.1]oct-3-yl; (R)-3-methyl-morpholin-4-yl; 4-cyclopropanecarbonyl-piperazin-1-yl; 4 (1 -hydroxy- 1 -methyl-ethyl)-piperidin- 1-yl; 4-cyclobutyl-piperazin- 1-yl; (R)-3-hydroxy pyrrolidin-1-yl; 4-oxetan-3-yl-piperazin-1-yl; 3-morpholin-4-yl-azetidin-1-yl; 4-(1-methyl piperidin-4-yl)-piperazin-1-yl; 3,3-difluoro-azetidin-1-yl; 4-dimethylamino-piperidin-1-yl; and 4-piperidin-4-yl-piperazin-1-yl. 15 In certain embodiments of formula I or formula II, R' and R 6 together with the nitrogen atom to which they are attached form morpholin-4-yl. In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form 4-hydroxy-piperidin-1-yl. In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen 20 atom to which they are attached form octahydro-pyrido[1,2-a]pyrazin-2-yl. In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form 2-hydroxy-piperidin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4,4-dimethyl-piperidin- 1-yl. 25 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3,5-dimethyl-piperidin- 1-yl. In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form 1 -hydroxy- 1 -methyl-ethyl)-piperidin- 1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 30 atom to which they are attached form 3-hydroxy-pyrrolidin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-methyl-piperidin- 1-yl.

33 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form piperidin- l-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form azetidin- l-yl. 5 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4,4-difluoro-piperidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-methyl-piperidin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 10 atom to which they are attached form 4-methoxy-piperidin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3,3-difluoro-piperidin-1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-cyano-piperidin- 1 -yl. 15 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-fluoro-piperidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-methoxy-piperidin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 20 atom to which they are attached form 4-ethyl-piperazin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-acetyl-piperazin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-trifluoromethyl-piperidin- l-yl. 25 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-tert-butyl-piperidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 30 atom to which they are attached form 2-hydroxy-ethyl)-piperazin-1-yl.

34 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 2-methyl-pyrrolidin- l-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-hydroxymethyl-piperidin-1-yl. 5 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 2-methyl-piperidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form pyrrolidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 10 atom to which they are attached form 4-methanesulfonyl-piperazin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-trifluoromethyl-pyrrolidin-1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-(2,2,2-trifluoro-ethyl)-piperazin-1-yl. 15 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 2-methyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form (2,6-dimethyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 20 atom to which they are attached form 2,2-diethyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-hydroxymethyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 2-isobutyl-morpholin-4-yl. 25 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 2-hydroxymethyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3,3-dimethyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 30 atom to which they are attached form 4-methyl-piperazin-1-yl.

35 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-isopropyl-piperazin- l-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form piperazin- l-yl. 5 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-oxa-8-aza-bicyclo[3.2.1]oct-8-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form (S)-3-methyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 10 atom to which they are attached form 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 8-oxa-3-aza-bicyclo[3.2.1]oct-3-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form (R)-3-methyl-morpholin-4-yl. 15 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-cyclopropanecarbonyl-piperazin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-(1 -hydroxy- 1 -methyl-ethyl)-piperidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 20 atom to which they are attached form 4-cyclobutyl-piperazin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form (R)-3 -hydroxy-pyrrolidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-oxetan-3-yl-piperazin-1-yl. 25 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-morpholin-4-yl-azetidin-1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 4-(1 -methyl-piperidin-4-yl)-piperazin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 30 atom to which they are attached form 3,3-difluoro-azetidin-1-yl.

36 In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form 4-dimethylamino-piperidin- l-yl. In certain embodiments of formula I or formula 11, R 5 and R 6 together with the nitrogen atom to which they are attached form 4-piperidin-4-yl-piperazin- l-yl. 5 In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form (4,4-difluoro-piperidin- 1 -yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form (3-morpholin-4-yl-azetidin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 10 atom to which they are attached form 2-oxa-6-aza-spiro[3.3]hept-6-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl).In certain embodiments of formula I or formula II, R5 and R6 together with the nitrogen atom to which they are attached form 4-methoxy-piperidin-1-yl). 15 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form [1,4]oxazepan-4-yl. In certain embodiments of formula I or formula II, R5 and R6 together with the nitrogen atom to which they are attached form 2R,6S)-2,6-dimethyl-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 20 atom to which they are attached form 3-hydroxy-azetidin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-cyano-pyrrolidin-1 -yl. In certain embodiments of formula I or formula II, R5 and R6 together with the nitrogen atom to which they are attached form 3,5-dimethyl-piperazin-1-yl. 25 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form (3R,5S)-dimethyl-piperazin-1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3-Fluoro-pyrrolidin-1 -yl. In certain embodiments of formula I or formula II, R5 and R6 together with the nitrogen 30 atom to which they are attached form (S)-3-Fluoro-pyrrolidin-1-yl.

37 In certain embodiments of formula I or formula II, R 5 and R 6 together with the nitrogen atom to which they are attached form piperazin- 1-yl. In certain embodiments of formula I or formula 11, R 5 and R 6 together with the nitrogen atom to which they are attached form 3,3-difluoro-pyrrolidin-1-yl. 5 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 3,3-difluoro-azetidin- 1-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form 2,2,6,6-tetrafluoro-morpholin-4-yl. In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen 10 atom to which they are attached form 2-methoxymethyl-pyrrolidin-1-yl.In certain embodiments of formula I or formula II, R5 and R6 together with the nitrogen atom to which they are attached form (S)-2-methoxymethyl-pyrrolidin-1-yl. In certain embodiments of formula I or formula II, R' and R 6 together with the nitrogen atom to which they are attached form (1S,4S)-2-oxa-5-azabicyclo[2.2. 1]heptan-5-yl. 15 In certain embodiments of formula I or formula II, R5 and R 6 together with the nitrogen atom to which they are attached form (3S,4S)-3,4-difluoropyrrolidin-1-yl; 3,4-difluoropyrrolidin 1-yl; and 3-methoxypyrrolidin-1-yl. In certain embodiments of formula I or formula II, R 7 is halo. In certain embodiments of formula I or formula II, R 7 is Ci- 6 alkyl. 20 In certain embodiments of formula I or formula II, Ris Ci 6 alkoxy. In certain embodiments of formula I or formula II, R is halo-Ci- 6 alkyl. In certain embodiments of formula I or formula II, R is halo-Ci- 6 alkoxy. In certain embodiments of formula I or formula II, R'is halo or methoxy. In certain embodiments of formula I or formula II, R 7 is fluoro, chloro or methoxy. 25 In certain embodiments of formula I or formula II, R is fluoro or chloro. In certain embodiments of formula I or formula II, R'is methoxy. In certain embodiments of formula I or formula II, R 7 is chloro. In certain embodiments of formula I or formula II, R 7 is fluoro.

38 In embodiments of formula I or formula II wherein R 5 and R6 together with the nitrogen atom to which they are attached form a three- to six-membered ring, the subject compounds may be represented by formula III: R X (R7 0 R8 2 (R)m R RN N )P N N H 3 R 5 wherein: p is from 0 to 2; Y is: -0-; -S(O)r-; -NR"; or -CR"R 12 when p is 1 or 2; and Y is -CR 1

'R-

12 when p is 0;

R

8 and R 9 each independently is: hydrogen; C1_ 6 alkyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy; halo C i 6 alkoxy; hydroxy; hydroxy-CI_ 6 alkyl; halo; nitrile; CI 6 alkyl-carbonyl; C 1 6 alkyl-sulfonyl; C 3 _ 10 6 cycloalkyl; C 3

_

6 cycloalkyl-CI 6 alkyl; C 3

_

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or R' and R 9 together with the atoms to which they are attached form a five- or six membered ring;

R

10 is: hydrogen; C 1

-

6 alkyl; hydroxy-C1_ 6 alkyl; halo-C1_ 6 alkyl; hydroxy-C1_ 6 alkyl; C 1 _ 6 alkyl-carbonyl; C 1- 6 alkyl-sulfonyl; C 3

-

6 cycloalkyl; C 3

-

6 cycloalkyl-C1- 6 alkyl; C 3

-

6 cycloalkyl 15 carbonyl; heterocyclyl; or heterocyclyl-CI_ 6 alkyl; or one of R" and R 9 together with R 1 0 and the atoms to which they are attached form a five- or six-membered ring; R" is: hydrogen; C 1

-

6 alkyl; or halo;

R

12 is: hydrogen; C1_ 6 alkyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy; halo-C1_ 6 alkoxy; hydroxy; 20 hydroxy-C1_ 6 alkyl; halo; nitrile; C1_ 6 alkyl-carbonyl; C1_ 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3 _ 6 cycloalkyl-C1- 6 alkyl; C 3 -6cycloalkyl-carbonyl; amino; heterocyclyl; or heterocyclyl-CI_ 6 alkyl; or R" and R 1 2 together with the atom to which they are attached may form a 3- to six membered ring that optionally includes a heteroatom selected from 0, N and S; or one of R 8 and R 9 together with R 1 0 and the atoms to which they are attached form a 25 five- or six-membered ring; or one of R 8 and R 9 together with R 12 and the atoms to which they are attached form a five- or six-membered ring; and 39 1 27 m, r, X, R , R , R3 and Ri are as defined herein. In certain embodiments of formula III, p is 0 or 1. In certain embodiments of formula III, p is 0. In certain embodiments of formula III, p is 1. 5 In certain embodiments of formula IlI, p is 2. In certain embodiments of formula III, Y is -0-; -NR 0 ; or -CR"R 12 In certain embodiments of formula III, Y is -0-. In certain embodiments of formula III, Y is -NR1 0 -. In certain embodiments of formula III, Y is -S(O),-. 11 12 10 In certain embodiments of formula III, Y is -CRo R. In certain embodiments of formula III, R8 is hydrogen. In certain embodiments of formula III, R9 is hydrogen. In certain embodiments of formula III, R 8 and R9 are hydrogen. In certain embodiments of formula I1I, R 8 and R 9 are hydrogen, C1-6alkyl or halo. 15 In certain embodiments of formula III, R" and R 9 together with the atoms to which they are attached form a five- or six-membered ring. In certain embodiments of formula III, one of R' and R9 together with R 10 and the atoms to which they are attached form a five- or six-membered ring. In certain embodiments of formula III, one of R and R9 together with R 12 and the atoms 20 to which they are attached form a five- or six-membered ring. In certain embodiments of formula III, R 1 0 is hydrogen. In certain embodiments of formula III, R 1 0 is C1_6alkyl. In certain embodiments of formula III, R 10 is hydroxy-C 1

_

6 alkyl. In certain embodiments of formula III, R' 0 is halo-C1_ 6 alkyl 25 In certain embodiments of formula III, R 10 is hydroxy-C 1

_

6 alkyl.

40 In certain embodiments of formula III, RUis C1_ 6 alkyl-carbonyl. In certain embodiments of formula III, R 1 Uis C1- 6 alkyl-sulfonyl. In certain embodiments of formula III, R 1 Uis C3-6cycloalkyl In certain embodiments of formula III, R 0 is C3- 6 cycloalkyl-C1- 6 alkyl. 5 In certain embodiments of formula IlI, R 1 0 isC 3

-

6 cycloalkyl-carbonyl. In certain embodiments of formula III, R 10 is heterocyclyl. In certain embodiments of formula III, R' 0 is heterocyclyl-C1_ 6 alkyl. In certain embodiments of formula III, R 11 is hydrogen or C1 6 alkyl. In certain embodiments of formula III, R 1 'and R 12 are hydrogen. 10 In certain embodiments of formula III, R 1 'is hydrogen. In certain embodiments of formula III, R 11 is C1s 6 alkyl. In certain embodiments of formula III, R 1 'is halo. In certain embodiments of formula III, R 12 is hydrogen. In certain embodiments of formula III, R is C 1-6alkyl. 15 In certain embodiments of formula III, R is halo-C1_6alkyl. In certain embodiments of formula III, R 12 is C1- 6 alkoxy. In certain embodiments of formula III, R 12 is halo-C1-6alkoxy. In certain embodiments of formula III, R 12 is hydroxy. In certain embodiments of formula III, R 12 is hydroxy-C1_alkyl. 20 In certain embodiments of formula III, R 12 is halo. In certain embodiments of formula III, R 12 is nitrile. In certain embodiments of formula III, R is C1_alkyl-carbonyl. In certain embodiments of formula III, R is C 1

_

6 alkyl-sulfonyl. In certain embodiments of formula III, R is C 3

_

6 cycloalkyl.

41 in certain embodiments of formula III, R is C3_6cycloalkyl-Ci-alkyl. In certain embodiments of formula III, R is C 3

-

6 cycloalkyl-carbonyl. In certain embodiments of formula III, R is amino. In certain embodiments of formula III, R1 2 is dimethylamino. 5 In certain embodiments of formula 111, R12is heterocyclyl. In embodiments of formula III wherein R 10 is heterocyclyl, such heterocyclyl may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; morpholinyl; thiomorpholinyl; 3-oxa-8-aza bicyclo[3.2.1]oct-8-yl; 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl; or 8-oxa-3-aza-bicyclo[3.2.1]oct-3 yl; each optionally substituted with one, two or three groups independently selected from: C 1 _ 10 6 alkyl; halo-C1- 6 alkyl; Ci- 6 alkoxy; halo-Ci- 6 alkoxy; hydroxy; hydroxy-Ci- 6 alkyl; halo; nitrile; C 1 _ 6 alkyl-carbonyl; CI_ 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3

_

6 cycloalkyl-CI- 6 alkyl; C 3

_

6 cycloalkyl carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring. In embodiments of formula III wherein R 10 is heterocyclyl, such heterocyclyl may be: 15 azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; or morpholinyl; each optionally substituted as defined herein. In embodiments of formula III wherein R 10 is heterocyclyl-C1_ 6 alkyl, the heterocyclyl portion thereof may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; morpholinyl; thiomorpholinyl; 3-oxa-8-aza-bicyclo[3.2.1]oct-8-yl; 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl; or 8 20 oxa-3-aza-bicyclo[3.2.1]oct-3-yl; each optionally substituted as defined herein. In embodiments of formula III wherein R 10 is heterocyclyl-CI 6 alkyl, the heterocyclyl portion thereof may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; or morpholinyl; each optionally substituted with one, two or three groups independently selected from: Ci- 6 alkyl; halo C1- 6 alkyl; CI_ 6 alkoxy; halo-C1- 6 alkoxy; hydroxy; hydroxy-CI_ 6 alkyl; halo; nitrile; Ci- 6 alkyl 25 carbonyl; C1_ 6 alkyl-sulfonyl; C 3

_

6 cycloalkyl; C 3

_

6 cycloalkyl-C1_ 6 alkyl; C3_ 6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring.. In embodiments of formula III wherein R is heterocyclyl, such heterocyclyl may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; morpholinyl; thiomorpholinyl; 3-oxa-8-aza 30 bicyclo[3.2.1]oct-8-yl; 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl; or 8-oxa-3-aza-bicyclo[3.2.1]oct-3 yl; each optionally substituted as defined herein. In embodiments of formula III wherein R is heterocyclyl, such heterocyclyl may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; or morpholinyl; each optionally substituted 42 with one, two or three groups independently selected from: C1_ 6 alkyl; halo-C1_ 6 alkyl; CI 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI_ 6 alkyl; halo; nitrile; Ci- 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl;

C

3

-

6 cycloalkyl; C 3

-

6 cycloalkyl-Ci- 6 alkyl; C 3

-

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six 5 membered ring.. In embodiments of formula III wherein R is heterocyclyl-CI-6alkyl, the heterocyclyl portion thereof may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; morpholinyl; thiomorpholinyl; 3-oxa-8-aza-bicyclo[3.2.1]oct-8-yl; 2-oxa-5-aza-bicyclo[2.2.1]hept-5-yl; or 8 oxa-3-aza-bicyclo[3.2.1]oct-3-yl; wherein the heterocyclyl portion each is optionally substituted 10 with one, two or three groups independently selected from: Ci- 6 alkyl; halo-Ci- 6 alkyl; CI- 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI_ 6 alkyl; halo; nitrile; CI_ 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl;

C

3

-

6 cycloalkyl; C 3

-

6 cycloalkyl-Ci- 6 alkyl; C 3

-

6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six membered ring. 15 In embodiments of formula III wherein R is heterocyclyl-Ci- 6 alkyl, the heterocyclyl portion thereof may be: azetidinyl; pyrrolidinyl; piperidinyl; piperazinyl; or morpholinyl; each optionally substituted as defined herein. In certain embodiments of formula III, R" and R 12 together with the atom to which they are attached form a 3- to six-membered ring that optionally includes a heteroatom selected from 20 0, N and S. In certain embodiments, the subject compounds may be represented more particularly by formula IV:

(R

7 )m R N N H R 9

R

3 IV wherein m, X, R1, R2, R 3, R', R' and R 9 are as defined herein. 25 In certain embodiments, the subject compounds may be represented more particularly by formula V: 43 R1%x o

(R

7 )m R8 R2 NN NP N N "K N N, R10 H R wherein m, X, R , R2, R3, R', R', R' and R" are as defined herein. In certain embodiments, the subject compounds may be represented more particularly by formula VI: x 0 (R)m

R

8 R2 N N N N R12 H R 9 R1 5 R3 2 3 VI wherein m, X, R1, R2, R 3, R', R', R9, R" and R 12 are as defined herein. In certain embodiments, the subject compounds may be represented more particularly by formula VII: x 7o R2 N(R R 8 'N ) N H R 3 R9VI 1 2 3 7 8 9 112 10 wherein m, X, R, R, R, R, R, R, R and R are as defined herein. In certain embodiments, the subject compounds may be represented more particularly by formula VIII: R R N N ) N N H R R 4VIII 44 wherein m, p, X, Y, R', R2, R 4, R', R' and R 9 are as defined herein. In certain embodiments, the subject compounds may be represented more particularly by formula IX: X 7O 2 (R ) R 8 N N N N H R 9 R4 IX 5 wherein m, X, R1, R2, R , R', R' and R 9 are as defined herein. In certain embodiments, the subject compounds may be represented more particularly by formula X:

RR

7 R2 RN1x (R )m 0 R 8 N N N NN N R" H R R4 0 wherein m, X, R1, R2, R 4, R', R', R9 and R 10 are as defined herein. 10 In certain embodiments, the subject compounds may be represented more particularly by formula XI: 2

(R

7 )m 0 R R R12 N N 11 H R R R 4xi wherein m, X, R1, R2, R 4, R', R', R9, R" and R 12 are as defined herein. In certain embodiments, the subject compounds may be represented more particularly by 15 formula XII: 45 R2 (R ) 0 R 8 N N R12 N N R9 H R 4,0 XII wherein m, X, R1, R2, R 4, R', R', R9, R" and R 12 are as defined herein. In embodiments the subject compounds may be represented by formula XIII: R1R 7 0 2

R

8 RN N )1Y N N H R9 1 233 7 8 5 wherein p, X, Y, R1, R2, R', R', R' and R 9 are as defined herein. Where any of R 1 , R2, R 3 , R 4 , R', R , RI, R', R 9 , R" and R is alkyl or contains an alkyl moiety, such alkyl is preferably lower alkyl, i.e. CI 6 alkyl, and in many embodiments may be C 1 _ 4 alkyl. In certain embodiments, the invention provides compound as described herein, selected 10 from the group consisting of 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-ethyl)-2-methoxy benzamide, 5-Chloro-N-cyclopropyl-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino) 15 benzamide, ((2S,6R)-2,6-dimethylmorpholino)(2-fluoro-5-methoxy-4-(4-(methylamino)-5 (trifluoromethyl)pyrimidin-2-ylamino)phenyl)methanone, (iS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl(2-fluoro-3-methoxy-4-(4-(methylamino)-5 (trifluoromethyl)pyrimidin-2-ylamino)phenyl)methanone, 20 (iS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)-2-fluoro-3-methoxyphenyl)methanone, (2,6-Dimethyl-morpholin-4-yl)-[3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2 ylamino)-phenyl]-methanone, (2-ethoxy-5-fluoro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 25 ylamino)phenyl)(morpholino)methanone, 46 (2-fluoro-3 -isopropoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, (2-fluoro-3 -isopropoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, 5 (2-fluoro-5 -methoxy-4-(4-(2-methoxyethoxy)-5 -(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, (2-fluoro-5 -methoxy-4-(4-(methylamino)-5 -(trifluoromethyl)pyrimidin-2-ylamino)phenyl)(3 methoxypyrrolidin- 1 -yl)methanone, (3-methoxy-4-(5-methoxy-4-(methylamino)pyrimidin-2-ylamino)phenyl) 10 (morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-3 methoxyphenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-3 isopropoxyphenyl)(morpholino)methanone, 15 (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3 (trifluoromethoxy)phenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3 (trifluoromethoxy)phenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl-amino)-3 20 isopropoxyphenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromcthyl)pyrimidin-2-ylamino)-3 isopropoxyphenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5 -fluoro-2 meth oxyph enyl)(morpho lino)meth anonec, 25 (4-(4-(mcthylamino)-5 -(trifluoromcthyl)pyrimidin-2-ylamino)-3 (trifluoromethoxy)phenyl)(morpholino)methanone, (4-(5 -bromo-4-methoxypyrimidin-2-ylamino)-3 -methoxyphenyl)(3-(trifluoromethyl)pyrrolidin 1 -yl)methanone, (4-(5 -chloro-4-(methylamino)pyrimidin-2-ylamino)-3 -methylphenyl)(morpholino)methanone, 30 (4-(5 -chloro-4-(methylamino)pyrimidin-2-ylamino)-3 -methylphenyl)(4-hydroxypiperidin- 1 yl)methanone, (4-(5 -chloro-4-(piperidin- I -yI)pyrimidin -2-yl amino)-3-methoxyphenyl)(morpho lino)methanone, (4-(5 -chloro-4-(pyrrolidin- 1 -yl)pyrimidin-2-ylamino)-3 -methoxyphenyl)(morpholino)methanone, (4-(5 -chloro-4-methoxypyrimidin-2-ylamino)-3 -methoxyphenyl)(pyrrolidin- I -yl)methanone, 35 (4-(5 -cyclopropyl-4-methoxypyrimidin-2-ylamino)-3 -methoxyphenyl)(morpholino)methanone, (4- { 5 -Chloro-4- [(tetrahydro-furan-2-ylmethyl)-amino]-pyrimidin-2-ylamino } -3-methoxy phenyl)-morpholin-4-yl-methanone, (4- {5 -Chloro-4- (tetrahydro-furan-3 -ylmethyl)-amino]-pyrimidin-2-ylamino } -3-methoxy phenyl)-morpholin-4-yl-methanone, 47 (4-Dimethylamino-piperidin-I -yl)-[3 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin 2-ylamino)-phenyl] -methanone, (4-tert-Butyl-piperidin- Il-yl)- [4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy phenyl]-methanone , 5 (5-chloro-2-methoxy-4-(4-(methylamino)-5 -(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(perdeuteromorpholino)methanone, (5-chloro-2-methoxy-4-(4-(methylamino)-5 -(trifluoromethyl)pyrimidin-2-ylamino)phenyl)(3 methoxypyrrolidin- 1 -yl)methanone, (5-chloro-4-(5 -chloro-4-(methylamino)pyrimidin-2-ylamino)-2 10 methoxypheny1)(morpholino)methanone, (5-fluoro-2-methoxy-4-(4-(methylamino)-5 -(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, [2-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-5-methoxy-phenyl]-morpholin-4 yl-methanone, 15 [2-Chloro-5 -methoxy-4-(4-methoxy-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [2-Chloro-5 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [2-Fluoro-3 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] 20 morpholin-4-yl-methanone, [2-Fluoro-5 -mcthoxy-4-(4-methylamino-5 -trifluoromcthyl-pyrimidin-2-ylamino)-phcnyl] morpholin-4-yl-methanone, [2-Fluoro-5 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -((S)-2 methoxym ethyl -pyrrolIi din -I -yl)-meth anone, 25 [3-(2-Eluoro-cthoxy)-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [3-Bromo-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl meth anon e, [3-Bromo-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl-methanone, 30 [3-Chloro-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl methanone, [3-Chloro-4-(5 -chloro-4-methoxy-pyrimi din-2-ylamino)-phenyl]-morpholin-4-yl-methanone, [3-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl-methanone, [3-Cyclobutoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin 35 4-yl-methanone, [3-Cyclobutylmethoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, L3-Cyclopropyl-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morphiolin 4-yl-methanone, 48 [3-Cyclopropylmethoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [3-Ethoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl methanone, 5 [3-Isopropoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4 yl-methanone, [3-Methoxy-4-(4-methoxy-5 -prop-i -ynyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl methanone, [3-Methoxy-4-(4-methoxy-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl 10 methanone, [3-Methoxy-4-(4-methylamino-5 -prop-i -ynyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl methanone, [3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl methanone, 15 [3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(8-oxa-3-aza bicyclo[3.2.1 ]oct-3-yl)-methanone, [3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(2-oxa-5-aza bicyclo[2.2.1 ]hept-5-yl)-methanone, [3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-pyrrolidin- 1-yl 20 methanone, [3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-[4-(2,2,2 trifluoro-ethyl)-piperazin- 1 -yl]-methanone, [3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(4-methoxy piperidin-1 -yl)-methanone, 25 [3-Methoxy-4-(4-pyrrolidin- 1-yl-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4 yl-methanone, [4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl] morpholin-4-yl-methanone, [4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl]-((S)-2 30 methoxymethyl-pyrrolidin- 1 -yl)-methanone, [4-(5-Bromo-4-ethoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [4-(5-Bromo-4-isopropoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-2-chloro-5-methoxy-phenyl]-morpholin-4-yl 35 methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-cyclobutoxy-phenyl]-morpholin-4-yl methanone, 49 [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-cyclopropoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-ethoxy-phenyl]-morpholin-4-yl-methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-isopropoxy-phenyl]-morpholin-4-yl 5 methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-((R)-2,2-di-deutero-3 methyl-morpholin-4-yl)-methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-((S)-2,2-di-deutero-3 methyl-morpholin-4-yl)-methanone, 10 [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-morpholin-4-yl-azetidin 1 -yl)-methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4,4-difluoro-piperidin- 1-yl) methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-ethyl-piperazin- 1-yl) 15 methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]- [4-(1 -hydroxy- 1-methyl ethyl)-piperidin- 1 -yl]-methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl 20 methanone, [4-(5 -Bromo-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]- [4-(1 -hydroxy- 1-methyl ethyl)-piperidin- 1 -yl]-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-trifluoromethyl pyrrolidin-1 -yl)-methanone, 25 [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-cyclobutyl-piperazin I -yl)-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-[4-(2,2,2-trifluoro ethyl)-piperazin- I -yl]-methanone, [4-(5 -Bromo-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-methoxy-piperidin- 1 30 yl)-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-((R)-3-hydroxy pyrrolidin- I -yl)-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-oxetan-3-yl piperazin- I -yl)-methanone, 35 [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-5-chloro-2-methoxy-phenyl]-morpholin-4 yl-methanone, [4-(5-Chloro-4-cyclobutylamino-pyrimidin-2-ylanino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Chloro-4-cyclohexylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl 40 methanone, 50 [4-(5 -Chloro-4-cyclopentylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -morpholin-4-yl methanone, [4-(5 -Chloro-4-ethoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -morpholin-4-yl-methanone, [4-(5 -Chloro-4-ethylamino-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl] -morpholin-4-yl 5 methanone, [4-(5 -Chloro-4-ethylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-isobutylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, 10 [4-(5 -Chloro-4-isopropoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-isopropylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-methoxy-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-phenyl] -morpholin-4-yl 15 methanone, [4-(5 -Chloro-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-phenyl] -morpholin-4 yl-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -(2,2,2-trifluoro-ethoxy)-phenyl] 20 morpholin-4-yl-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -(oxetan-3 -yloxy)-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclobutoxy-phenyl] -morpholin-4-yl methanon e, 25 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopentyloxy-phenyl] -(2-oxa-6-aza spiro [3.3 ]hept-6-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopentyloxy-phenyl] -morpholin-4-yl meth anon e, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopropoxy-phenyl]-morpholin-4-yl 30 methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopropyl-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -difluoromethoxy-phenyl]-morpholin-4-yl methanone, 35 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -difluoromethoxy-phenyl]-(4-hydroxy piperidin- 1 -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -ethoxy-phenyl] -morpholin-4-yl methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -hydroxy-phenyl]-morpholin-4-yl 40 methanone, 51 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-isopropoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, 5 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-hydroxy-piperidin- 1 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(octahydro-pyrido[1,2 a]pyrazin-2-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-hydroxy-piperidin- 1 10 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4,4-dimethyl-piperidin 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3,5-dimethyl-piperidin 1 -yl)-methanone, 15 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]- [4-(1 -hydroxy- 1-methyl ethyl)-piperidin- 1 -yl]-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-hydroxy-pyrrolidin 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-methyl-piperidin-1 20 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-piperidin- 1-yl methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4,4-difluoro-piperidin I -yl)-methanone, 25 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-methyl-piperidin-1 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-methoxy-piperidin- 1 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3,3-difluoro-piperidin 30 1 -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-fluoro-piperidin- 1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(3 -methoxy-piperidin- 1 yl)-methanone, 35 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-ethyl-piperazin- 1-yl) methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-trifluoromethyl piperidin- 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-[4-(2-hydroxy-ethyl) 40 piperazin-1-yl]-methanone, 52 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(2-methyl-pyrrolidin- 1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-hydroxymethyl pip eridin- 1 -yl)-methanone, 5 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(2-methyl-piperidin- 1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-pyrrolidin- Il-yl methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-methanesulfonyl 10 piperazin- 1 -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(3 -trifluoromethyl pyrrolidin- 1 -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]- [4-(2,2,2-trifluoro ethyl)-piperazin- Il-yl] -methanone, 15 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(2-methyl-morpholin-4 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(2,6-dimethyl morpholin-4-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(2,2-diethyl-morpholin 20 4-yl)-methanone, [4-(5 -Chloro-4-mcthylamino-pyrimidin-2-ylamino)-3 -mcthoxy-phcnyl]-(3 -hydroxymethyl morpholin-4-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(2-isobutyl-morpholin 4-yl)-methanone, 25 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -mcthoxy-phcnyl]-(2-hydroxymcthyl morpholin-4-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(3,3 -dimethyl morpholin-4-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(4-methyl-piperazin- 1 30 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-isopropyl-piperazin 1 -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-piperazin- Il-yl methanone, 35 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(3 -oxa-8-aza bicyclo [3.2. 1 ]oct-8-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -((S)-3 -methyl morpholin-4-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(2-oxa-5 -aza 40 bicyclo [2.2.1 ]hept-5 -yl)-methanone, 53 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(8-oxa-3-aza bicyclo[3.2.1 ]oct-3-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-((R)-3-methyl morpholin-4-yl)-methanone, 5 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4 cyclopropanecarbonyl-piperazin- 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-morpholin-4-yl azetidin- 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-[4-(1-methyl-piperidin 10 4-yl)-piperazin- 1 -yl]-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(3,3 -difluoro-azetidin- 1 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-dimethylamino piperidin- 1 -yl)-methanone, 15 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-piperidin-4-yl piperazin- 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-oxa-6-aza spiro[3.3]hept-6-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-trifluoromethoxy-phenyl]-morpholin-4-yl 20 methanone, [4-(5-Chloro-4-propoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [4-(5-Chloro-4-propylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Cyclobutyl -4-methoxy-pyrimi din-2-yl amino)-3 -methoxy-phenyl ]-morpholin-4-yl 25 methanone, [4-(5-Cyclobutyl-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Cyclopropyl-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, 30 [4-(5-Cyclopropyl-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Fluoro-4-methyl amino-pyrimi din-2-yl amino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Fluoro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-hydroxy-piperidin- 1 35 yl)-methanone, [4-(5-Iodo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [4-(5-Iodo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [4-[5-Chloro-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino]-3-(2,2,2-trifluoro-ethoxy) phenyl]-morpholin-4-yl-methanone, 54 [5-Chloro-2-ethoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [5-Chloro-2-methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] piperazin-1I -yl-methanone, 5 [5-Chloro-2-methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -(2,6 dimnethyl-morpholin-4-yl)-methanone, [5-Chloro-2-methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [5-Chloro-4-(4-ethylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-2--methoxy-phenyl] 10 morpholin-4-yl-methanone, [5-Chloro-4-(5 -chloro-4-ethylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-morpholin-4-yl methanone, [5-Chloro-4-(5 -chloro-4-methoxy-pyrimidin-2-ylamino)-2-methoxy-phenyl] -morpholin-4-yl methanone, 15 [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-morpholin-4 yl-methanone, [5-Chloro-4-(5 -chloro-4-mcthylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(4,4-difluoro pip eridin- 1 -yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-piperazin- Il-yl 20 methanone, [5-Chloro-4-(5 -chloro-4-mcthylamino-pyrimidin-2-ylamino)-2-methoxy-pheny] -(4 dimethylamino-piperidin-1I-yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2--ylamino)-2-methoxy-pheny]-(3-hydroxy pyrrolidin-1I -yl)-metbanone, 25 [5-Chloro-4-(5 -chloro-4-mcthylamino-pyrimidin-2-ylamino)-2-mcthoxy-phenyl]-pyrrolidin- 1 yl-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(4-hydroxy piperidin- 1 -yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-pheny] -(2 30 hydroxymethyl-morpholin-4-yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-pheny]-[ 1 ,4]oxazepan 4-yl-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-((2R,6S)-2,6 dimethyl-morpholin-4-yl)-methanone, 35 [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(3-hydroxy azetidin- 1 -yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-pheny]-((3R,5 S) dimethyl-piperazin- 1 -yl)-methanone, [5-Lthoxy-2-fluoro-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] 40 morpholin-4-yl-methanone, 55 [5-Ethoxy-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-phenyl] morpholin-4-yl-methanone, {4-[5 -Bromo-4-(2-methoxy-ethoxy)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} -morpholin-4-yl methanone, 5 f 4-[5 -Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino] -2-fluoro-5 -methoxy-pheny} morpholin-4-yl-methanone, {4-[5 -Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino] -3 -ethoxy-phenyl} -morpholin-4 yl-methanone, {4-[5 -Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino]-3 -isopropoxy-phenyl} 10 morpholin-4-yl-methanone, {4-[5 -Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} -morpholin 4-yl-methanone, {4-[5 -Chloro-4-( 1 -methyl-cyclobutylamino)-pyrimidin-2-ylamino]-3-methoxy-phenyl} morpholin-4-yl-methanone, 15 {4-[5 -Chloro-4-(2,2,2-trifluoro-ethylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} morpholin-4-yl-methanone, {4-[5 -Chloro-4-(2,2-difluoro-ethylamino)-pyrimidin-2-ylamino]-3 -methoxy-phcnyl} -morpholin 4-yl-methanone, {4- [5-Chloro-4-(2-cyclopropyl-ethylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} 20 morpholin-4-yl-methanone, {4-15 -Chloro-4-(2-mcthanesulfonyl-cthylamino)-pyrimidin-2-ylamino]-3-mcthoxy-phenyl morpholin-4-yl-methanone, {4-[5 -Chloro-4-(2-methoxy-ethoxy)-pyrimidin-2-ylamino]-3-cyclobutoxy-phenyl -morpholin-4 yl-methanone, 25 {4-[5 -Chloro-4-(2-methoxy-ethoxy)-pyrimidin-2-ylamino]-3 -mcthoxy-phenyl} -morpholin-4-yl methanone, {4-[5 -Chloro-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino] -3 -cyclobutoxy-phenyl} morpholin-4-yl -meth anon e, {4-[5 -Chloro-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} -morpholin 30 4-yl-methanone, {4-[5 -Chloro-4-(2-methoxy-propylamino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} -morpholin 4-yl-methanone, {4-[5 -Chloro-4-(cyclobutylmethyl-amino)-pyrimidin-2-ylamino]-3-methoxy-pheny} morpholin-4-yl-methanone, 35 {4-[5 -Chloro-4-(cyclopentylmethyl-amino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} morpholin-4-yl-methanone, {4-[5 -Chloro-4-(cyclopropylmethyl-amino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} morpholin-4-yl-methanone, {4-[5 -Chloro-4-(tetrahydro-furan-3 -ylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl) 40 morpholin-4-yl-methanone, 56 {4-[5 -Chloro-4-(tetrahydro-pyran-3-ylamino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} morpholin-4-yl-methanone, {4-[5 -Chloro-4-(tetrahydro-pyran-4-yloxy)-pyrimidin-2-ylamino]-3 -methoxy-phenyl) morpholin-4-yl-methanone, 5 1 -(4-(5 -bromo-4-methoxypyrimidin-2-ylamino)-3 -methoxybenzoyl)piperidine-4-carbonitrile, 1 -[2-Fluoro-5 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-benzoyl] pyrrolidine-3 -carbonitrile, 1 -[3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-benzoyl]-piperidine-4 carbonitrile, 10 1 -[4-(5 -Bromo-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzoyl]-piperidine-4 carbonitrile, 1 -[4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzoyl]-piperidine-4 carbonitrile, 1 -[5-Chloro-2-methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-benzoyl] 15 pyrrolidine-3-carbonitrile, 1 -[5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-benzoyl]-piperidine 4-carbonitrile, 1 -[5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2--ylamino)-2-methoxy-benzoyl]-pyrrolidine 3 -carbonitrile, 20 1 -{2- [2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino] -4-methylamino-pyrimidin-5 -yl} cthanone, I- {4- [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzoyl] -piperazin- l-yl} ethanone, 2-(2-methoxy-4-(2,2,6,6-tetrafluoromorpholine-4-carbonyl)phenylamino)-4 25 (methylamino)pyrimidine-5 -carbonitrile, 2-(2-methoxy-4-(morpholine-4-carbonyl)phenylamino)-4-(methylamino)pyrimidine-5 carbonitrile, 2-(4-((3 S,4S)-3 ,4-di fluoropyrrolidine- 1 -carbonyl)-2-methoxyphenyl amino)-4 (methylamino)pyrimidine-5 -carbonitrile, 30 2-(4-(4,4-difluoropiperidine- I -carbonyl)-2-methoxyphenylamino)-4-(methylamino)pyrimidine 5 -carbonitrile, 2-[2,5 -Dim ethoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-yl amino)-phenyl morpholin-4-yl-ethanone, 2-[2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino]-4-methylamino-pyrimidine-5 35 carbonitrile, 2-[2-Methoxy-4-(piperidine- 1 -carbonyl)-phenylamino]-4-methylamino-pyrimidine-5 carbonitrile, 2-[2-Methoxy-4-(pyrrolidine- 1 -carbonyl)-phenylamino] -4-methylamino-pyrimidine-5 carbonitrile, 57 2-[3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]- 1 -morpholin 4-yl-ethanone, 2-[4-((2R,6S)-2,6-Dimethyl-morpholine-4-carbonyl)-5-fluoro-2-methoxy-phenylamino]-4 methylamino-pyrimidine-5-carbonitrile, 5 2-[4-((2R,6S)-2,6-Dimethyl-morpholine-4-carbonyl)-5-fluoro-2-methoxy-phenylamino]-4 ethylamino-pyrimidine-5-carbonitrile, 2-[4-((R)-3-Fluoro-pyrrolidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino pyrimidine-5-carbonitrile, 2-[4-((S)-3-Fluoro-pyrrolidine-1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino 10 pyrimidine-5-carbonitrile, 2-[4-(3,3-Difluoro-azetidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino-pyrimidine 5-carbonitrile, 2-[4-(3,3-Difluoro-pyrrolidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino pyrimidine-5-carbonitrile, 15 2-[4-(3-Fluoro-azetidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino-pyrimidine-5 carbonitrile, 2-[4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]- 1 -morpholin-4-yl-cthanone, 2-[4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-2,5-dimethoxy-phenyl]- 1 -morpholin-4-yl ethanone, 20 2-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-2,5-dimethoxy-phenyl] -1 -morpholin-4-yl ethanone, 2-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]- I -morpholin-4-yl-ethanone, 2-[4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-2,5-dimethoxy-phenyl]- 1 -morpholin-4-yl ethanone, 25 2-[4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]- 1 -morpholin-4-yl ethanone, 2-[4-(Azetidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino-pyrimidine-5-carbonitrile, 2-[5-Fluoro-2-methoxy-4-(morpholine-4-carbonyl)-phenyamino] -4-methylamino-pyrimi dine-5 carbonitrile, 30 2-Fluoro-5-methoxy-N-(2-methoxy-ethyl)-N-methyl-4-(4-methylamino-5-trifluoromethyl pyrimidin-2-ylamino)-benzamide, 2-Fluoro-5 -methoxy-N-methyl -4-(4-methyl amino-5 -trifluoromethyl -pyrimidin-2-yl amino) benzamide, 2-fluoro-N-(2-hydroxy-2-methylpropyl)-5-methoxy-N-methyl-4-(4-(methylamino)-5 35 (trifluoromethyl)pyrimidin-2-ylamino)benzamide, 3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-N-oxetan-3-yl benzamide, 3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-N-(1 -methyl-piperidin-4 yl)-benzamide, 58 3 -Methoxy-N-(2-methoxy-ethyl)-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino) benzamnide, 3 -Methoxy-N-(2-methoxy-ethyl)-N-methyl-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2 ylamino)-benzamide, 5 4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-N-(2-methoxy ethyl)-N-methyl-benzamide, 4-(4-Lthylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, 4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3 -methoxy-N-(2-methoxy-ethyl)-N 10 methyl-b enzamide, 4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-N,N,3 -trimethylbenzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy--N-(tetrahydro-pyran-3 -yl) benzamnide, 15 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-N,N-dimethyl-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-N-methyl-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -mcthoxy-N-oxctan-3 -yl-bcnzamidc, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-N-cyclopropyl-3 -methoxy-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-N-ethyl-3 -methoxy-benzamide, 20 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-N-isopropyl-3 -methoxy-benzamide, 4-(5-Cyano-4-cthylamino-pyrimidin-2-ylamino)-2-fluoro-5 -mcthoxy-N,N-dimethyl-bcnzamidc, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-N,N-dimethyl-benzarmde, 4-(5-Cyano-4-methylamino-pyrimidin-2--ylamino)-3-methoxy-N,N-dimethyl-benzamide, 4-(5 -Cyano-4-methyl amino-pyrimi din-2 -yl amino)-3 -methoxy-N-methyl -ben zamidce, 25 4-(5-Cyano-4-mcthylamino-pyrimidin-2--ylamino)-N-(2,2-difluoro-cthyl)-3 -methoxy-bcnzamidc, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-(3 ,3 -difluoro-cyclobutyl)-3 -methoxy benzamnide, 4-(5 -Cyano-4-methylamino-pyrimi din," -yl amino)-N,N-di ethyl -3 -methoxy-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-cyclopropylmethyl-3 -methoxy-benzamide, 30 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-ethyl-3-methoxy-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-ethyl-3-methoxy-N-methyl-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2-yl amino)-N-ethyl-N-isopropyl -3 -methoxy-benzami de, 4-(5-Cyano-4-methylamino-pyrimidin-2--ylamino)-N-isopropyl-3 -methoxy-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-isopropyl-3 -methoxy-N-methyl-benzamide, 35 4-Lthylamino-2-[5-fluoro-2--methoxy-4-(morpholine-4-carbonyl)-phenylamino]-pyrimdine-5 carbonitrile, 4-Methoxy-2-[2-methoxy-4-(morpholine-4-carbonyl)-phenylamino] -pyrimidine-5 -carbonitrile, 5 -Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyimidin-2-ylamino)-N -(1-methyl piperidin-4-yl)-benzamide, 59 5 -Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-N-oxetan-3 -yl benzamide, S -Chloro-2-methoxy-N,N-dimethyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino) benzamide, 5 5 -Chloro-4-(4-ethylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-2-methoxy-N-(2-methoxy ethyl)-benzamide, 5 -chloro-4-(5 -chloro-4-methoxypyrimidin-2-ylamino)-2-methoxy-N-methylbenzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N,N-dimethyl benzamide, 10 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-(2-methoxy-ethyl) benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-methyl-benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-oxetan-3-yl benzamide, 15 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-( 1 -methyl-piperidin 4-yl)-benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-(2-methoxy-ethyl)-N methyl-benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-( 1-methyl 20 cyclobutyl)-benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-N-( 1 -eyano-cyclopropyl)-2 methoxy-benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-2-methyl-propyl)-2 methoxy-benzamide, 25 5 -Chloro-4-(5 -chloro-4-mcthylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-cthyl)-2-methoxy-N methyl-benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-propyl)-2-methoxy benzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-N-cyclopropyl-2-methoxy 30 benzamide, 5 -Chloro-N-( 1-cyano-cyclopropyl)-2-methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin 2-ylamino)-benzamide, 5 -Chloro-N-( 1-cyano-cyclopropyl)-2-methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin 2-ylamino)-benzamide, 35 5 -Chloro-N-(2-hydroxy-2-methyl-propyl)-2-methoxy-4-(4-methylamino-5 -trifluoromethyl pyrimidin-2-ylamino)-benzamide, 5 -Chloro-N-(2-hydroxy-2-methyl-propyl)-2-methoxy-N-methyl-4-(4-methylamino-5 trifluoromethyl-pynimidin-2-ylamino)-benzamide, 5 -Chloro-N-cyclopropyl-4-(4-ethylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-2-methoxy 40 benzamide, 60 Azetidin- 1-yl-[4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-methanone, N-(3,3-Difluoro-cyclobutyl)-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2 ylamino)-benzamide, N-(3-aminopropyl)-4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxybenzamide, 5 N-(3-Amino-propyl)-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-benzamide, N-(3-Amino-propyl)-5-chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy benzamide, N-(4,4-Difluoro-cyclohexyl)-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2 ylamino)-benzamide, 10 N,N-Diethyl-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-benzamide, N-Ethyl-2-fluoro-5-methoxy-N-(2-methoxy-ethyl)-4-(4-methylamino-5-trifluoromethyl pyrimidin-2-ylamino)-benzamide, N-Ethyl-3-methoxy-N-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino) benzamide, 15 N-Ethyl-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-N-(2 methoxy-ethyl)-benzamide, N-tert-Butyl-4-(5-cyano-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-benzamide, and N-tert-Butyl-5-chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-benzamide, or a pharmaceutically acceptable salt thereof. 20 In certain embodiments, the invention provides compound as described herein, selected from the group consisting of [3-Methoxy-4-(4-methylamino-5 -tri fluoromethyl-pyrimidin-2-ylamino)-phenyl ] -morpholin-4-yl methanone, (5-chloro-2-methoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 25 ylamino)phenyl)(perdeuteromorpholino)methanone, (5-fluoro-2-methoxy-4-(4-(methyl amino)-5 -(trifluoromethyl)pyrimi din-2 ylamino)phenyl)(morpholino)methanone, [2-Fluoro-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, 30 [3-Chloro-4-(5 -chloro-4-methyl amino-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl-methanone, [3-Isopropoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4 yl-methanone, [4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl] morpholin-4-yl-methanone, 35 [4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [5-Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, 61 [5-Chloro-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-methoxy-phenyl] morpholin-4-yl-methanone, [5-Ethoxy-2-fluoro-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, 5 2-(2-methoxy-4-(morpholine-4-carbonyl)phenylamino)-4-(methylamino)pyrimidine-5 carbonitrile, and N-tert-Butyl-4-(5-cyano-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-benzamide, or a pharmaceutically acceptable salt thereof. In certain embodiments, the invention provides a composition comprising: 10 (a) a pharmaceutically acceptable carrier; and (b) a compound of claim 1. In certain embodiments, the invention provides a compound as described herein for use as therapeutically active substance. In certain embodiments, the invention provides a method for treating Parkinson's disease, 15 Huntington's disease, Lewie body dementia, Alzheimer's disease, L-Dopa induced dyskinesia, cancer or proliferative disorder such as kidney, breast, prostate, blood, papillary or lung cancer, acute myelogenous leukemia, or multiple myeloma, or inflammatory disease such as leprosy, Crohn's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, and ankylosing spondylytis, said method comprising administering to a subject in need thereof an effective amount of a 20 compound as described herein. In certain embodiments, the invention relates to the u of a compound as described herein for the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Parkinson's disease, Huntington's disease, Lewie body dementia, Alzheimer's disease, L-Dopa induced dyskinesia, cancer or proliferative disorder such as kidney, breast, prostate, blood, 25 papillary or lung cancer, acute myelogenous leukemia, or multiple myeloma, or inflammatory disease such as leprosy, Crohn's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, and ankylosing spondylytis. In certain embodiments, the invention provides compound as described herein for the use as therapeutically active substance for the therapeutic and/or prophylactic treatment of 30 Parkinson's disease, Huntington's disease, Lewie body dementia, Alzheimer's disease, L-Dopa induced dyskinesia, cancer or proliferative disorder such as kidney, breast, prostate, blood, papillary or lung cancer, acute myelogenous leukemia, or multiple myeloma, or inflammatory disease such as leprosy, Crohn's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, and ankylosing spondylytis.

62 In certain embodiments, the invention provides a method for treating Parkinson's disease, Huntington's disease, Lewie body dementia, Alzheimer's disease or L-Dopa induced dyskinesia, said method comprising administering to a subject in need thereof an effective amount of a compound as described herein. 5 In certain embodiments, the invention relates to the u of a compound as described herein for the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Parkinson's disease, Huntington's disease, Lewie body dementia, Alzheimer's disease or L-Dopa induced dyskinesia. In certain embodiments, the invention provides compound as described herein for the use 10 as therapeutically active substance for the therapeutic and/or prophylactic treatment of Parkinson's disease, Huntington's disease, Lewie body dementia, Alzheimer's disease or L-Dopa induced dyskinesia. In certain embodiments, the invention provides a method for treating Parkinson's disease, said method comprising administering to a subject in need thereof an effective amount of a 15 compound as described herein. In certain embodiments, the invention relates to the u of a compound as described herein for the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Parkinson's disease. In certain embodiments, the invention provides compound as described herein for the use 20 as therapeutically active substance for the therapeutic and/or prophylactic treatment of Parkinson's disease. The invention also provides a method for treating a disease or condition mediated by or otherwise associated with the LRRK2 receptor, the method comprising administering to a subject in need thereof an effective amount of a compound of the invention. 25 The disease may be a neurodegenerative disease such as Parkinson's disease, Huntington's disease or Lewie body dementia. The disease may be a CNS disorder such as Alzheimer's disease and L-Dopa induced dyskinesia. The disease may be a cancer or proliferative disorder such as kidney, breast, prostate, 30 blood, papillary or lung cancer, acute myelogenous leukemia, or multiple myeloma. The disease may be an inflammatory disease such as leprosy, Crohn's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, and ankylosing spondylytis.

63 The invention also provides a method for enhancing cognitive memory, the method comprising administering to a subject in need thereof an effective amount of a compound of the invention. Representative compounds in accordance with the methods of the invention are shown in 5 the experimental examples below. Synthesis Compounds of the present invention can be made by a variety of methods depicted in the illustrative synthetic reaction schemes shown and described below. The starting materials and reagents used in preparing these compounds generally are 10 either available from commercial suppliers, such as Aldrich Chemical Co., or are prepared by methods known to those skilled in the art following procedures set forth in references such as Fieser and Fieser's Reagents for Organic Synthesis; Wiley & Sons: New York, 1991, Volumes 1-15; Rodd's Chemistry of Carbon Compounds, Elsevier Science Publishers, 1989, Volumes 1-5 and Supplementals; and Organic Reactions, Wiley & Sons: New York, 1991, Volumes 1-40. The 15 following synthetic reaction schemes are merely illustrative of some methods by which the compounds of the present invention can be synthesized, and various modifications to these synthetic reaction schemes can be made and will be suggested to one skilled in the art having referred to the disclosure contained in this Application. The starting materials and the intermediates of the synthetic reaction schemes can be 20 isolated and purified if desired using conventional techniques, including but not limited to, filtration, distillation, crystallization, chromatography, and the like. Such materials can be characterized using conventional means, including physical constants and spectral data. Unless specified to the contrary, the reactions described herein may be conducted under an inert atmosphere at atmospheric pressure at a reaction temperature range of from about -78 'C 25 to about 150 'C, for example, from about 0 'C to about 125 'C, or conveniently at about room (or ambient) temperature, e.g., about 20 'C. Scheme A below illustrates one synthetic procedure usable to prepare specific 1 2 3 5 7 compounds of formula I or formula II, wherein X, m, R , R2, R , R , R' and R are as defined herein.

64 CI Step 1 R X Step 2 R HX-R 1 R 2 bR7 OH - N CI C N: CI R 3d ('m R X 1 R2 m Step 3 2 (R 7) N OH R NRN)R NN e HN- N N R R 3 H 3 R ~R3 Scheme 1 In step 1 of Scheme A, dichloropyrimidine compound a is reacted with reagent b to afford pyrimidine compound c. The reaction of step 1 may take place under polar solvent 5 conditions. In embodiments of the invention where X is -0- (reagent b is an alcohol), the reaction of step 1 may be carried out in the presence of base. In step 2, pyrimidine compound c undergoes reaction with aminobenzoic acid compound d to provide aminopyridine compound e. The reaction of step 2 may take place in polar protic solvent and in the presence of acid such as HCl. 10 An amide coupling reaction is carried out in step 3 wherein compound e is reacted with amine f to yield a compound of formula I or formula II in accordance with the invention. The amide coupling reaction of step 3 may utilize various well known amide coupling reagents such as carbodiimides (such as DCC, DIC, EDC and the like), aminium salts (such as HATU, HBTU, TBTU and the like), or phosphonium salts (such as BOP, PyBOP and the like), with or without 15 the presence of benzotriazole derivatives such as HOBt, HOAt, DhbtOH, and the like. In other embodiments amide formation may be achieved using an acid chloride or anhydride intermediate (not shown). Many variations on the procedure of Scheme A are possible and will suggest themselves to those skilled in the art. Specific details for producing compounds of the invention are 20 described in the Examples below. Administration and Pharmaceutical Composition The invention includes pharmaceutical compositions comprising at least one compound of the present invention, or an individual isomer, racemic or non-racemic mixture of isomers or a pharmaceutically acceptable salt or solvate thereof, together with at least one pharmaceutically 25 acceptable carrier, and optionally other therapeutic and/or prophylactic ingredients.

65 In general, the compounds of the invention will be administered in a therapeutically effective amount by any of the accepted modes of administration for agents that serve similar utilities. Suitable dosage ranges are typically 1-500 mg daily, for example 1-100 mg daily, and most preferably 1-30 mg daily, depending upon numerous factors such as the severity of the 5 disease to be treated, the age and relative health of the subject, the potency of the compound used, the route and form of administration, the indication towards which the administration is directed, and the preferences and experience of the medical practitioner involved. One of ordinary skill in the art of treating such diseases will be able, without undue experimentation and in reliance upon personal knowledge and the disclosure of this Application, to ascertain a therapeutically effective 10 amount of the compounds of the present invention for a given disease. The term "pharmaceutically acceptable excipient" denotes any ingredient having no therapeutic activity and being non-toxic such as disintegrators, binders, fillers, solvents, buffers, tonicity agents, stabilizers, antioxidants, surfactants or lubricants used in formulating pharmaceutical products. 15 Whenever a chiral carbon is present in a chemical structure, it is intended that all stereoisomers associated with that chiral carbon are encompassed by the structure. The invention also provides pharmaceutical compositions, methods of using, and methods of preparing the aforementioned compounds. All separate embodiments may be combined. 20 Compounds of the invention may be administered as pharmaceutical formulations including those suitable for oral (including buccal and sub-lingual), rectal, nasal, topical, pulmonary, vaginal, or parenteral (including intramuscular, intraarterial, intrathecal, subcutaneous and intravenous) administration or in a form suitable for administration by inhalation or insufflation. A particular manner of administration is generally oral using a 25 convenient daily dosage regimen which can be adjusted according to the degree of affliction. A compound or compounds of the invention, together with one or more conventional adjuvants, carriers, or diluents, may be placed into the form of pharmaceutical compositions and unit dosages. The pharmaceutical compositions and unit dosage forms may be comprised of conventional ingredients in conventional proportions, with or without additional active 30 compounds or principles, and the unit dosage forms may contain any suitable effective amount of the active ingredient commensurate with the intended daily dosage range to be employed. The pharmaceutical compositions may be employed as solids, such as tablets or filled capsules, semisolids, powders, sustained release formulations, or liquids such as solutions, suspensions, emulsions, elixirs, or filled capsules for oral use; or in the form of suppositories for rectal or 35 vaginal administration; or in the form of sterile injectable solutions for parenteral use. Formulations containing about one (1) milligram of active ingredient or, more broadly, about 66 0.01 to about one hundred (100) milligrams, per tablet, are accordingly suitable representative unit dosage forms. The compounds of the invention may be formulated in a wide variety of oral administration dosage forms. The pharmaceutical compositions and dosage forms may comprise 5 a compound or compounds of the present invention or pharmaceutically acceptable salts thereof as the active component. The pharmaceutically acceptable carriers may be either solid or liquid. Solid form preparations include powders, tablets, pills, capsules, cachets, suppositories, and dispersible granules. A solid carrier may be one or more substances which may also act as diluents, flavouring agents, solubilizers, lubricants, suspending agents, binders, preservatives, 10 tablet disintegrating agents, or an encapsulating material. In powders, the carrier generally is a finely divided solid which is a mixture with the finely divided active component. In tablets, the active component generally is mixed with the carrier having the necessary binding capacity in suitable proportions and compacted in the shape and size desired. The powders and tablets may contain from about one (1) to about seventy (70) percent of the active compound. Suitable 15 carriers include but are not limited to magnesium carbonate, magnesium stearate, talc, sugar, lactose, pectin, dextrin, starch, gelatine, tragacanth, methylcellulose, sodium carboxymethylcellulose, a low melting wax, cocoa butter, and the like. The term "preparation" is intended to include the formulation of the active compound with encapsulating material as carrier, providing a capsule in which the active component, with or without carriers, is 20 surrounded by a carrier, which is in association with it. Similarly, cachets and lozenges are included. Tablets, powders, capsules, pills, cachets, and lozenges may be as solid forms suitable for oral administration. Other forms suitable for oral administration include liquid form preparations including emulsions, syrups, elixirs, aqueous solutions, aqueous suspensions, or solid form preparations 25 which are intended to be converted shortly before use to liquid form preparations. Emulsions may be prepared in solutions, for example, in aqueous propylene glycol solutions or may contain emulsifying agents, for example, such as lecithin, sorbitan monooleate, or acacia. Aqueous solutions can be prepared by dissolving the active component in water and adding suitable colorants, flavors, stabilizers, and thickening agents. Aqueous suspensions can be prepared by 30 dispersing the finely divided active component in water with viscous material, such as natural or synthetic gums, resins, methylcellulose, sodium carboxymethylcellulose, and other well known suspending agents. Solid form preparations include solutions, suspensions, and emulsions, and may contain, in addition to the active component, colorants, flavors, stabilizers, buffers, artificial and natural sweeteners, dispersants, thickeners, solubilizing agents, and the like. 35 The compounds of the invention may be formulated for parenteral administration (e.g., by injection, for example bolus injection or continuous infusion) and may be presented in unit dose form in ampoules, pre-filled syringes, small volume infusion or in multi-dose containers with an added preservative. The compositions may take such forms as suspensions, solutions, or 67 emulsions in oily or aqueous vehicles, for example solutions in aqueous polyethylene glycol. Examples of oily or nonaqueous carriers, diluents, solvents or vehicles include propylene glycol, polyethylene glycol, vegetable oils (e.g., olive oil), and injectable organic esters (e.g., ethyl oleate), and may contain formulatory agents such as preserving, wetting, emulsifying or 5 suspending, stabilizing and/or dispersing agents. Alternatively, the active ingredient may be in powder form, obtained by aseptic isolation of sterile solid or by lyophilization from solution for constitution before use with a suitable vehicle, e.g., sterile, pyrogen-free water. The compounds of the invention may be formulated for topical administration to the epidermis as ointments, creams or lotions, or as a transdermal patch. Ointments and creams may, 10 for example, be formulated with an aqueous or oily base with the addition of suitable thickening and/or gelling agents. Lotions may be formulated with an aqueous or oily base and will in general also containing one or more emulsifying agents, stabilizing agents, dispersing agents, suspending agents, thickening agents, or coloring agents. Formulations suitable for topical administration in the mouth include lozenges comprising active agents in a flavored base, usually 15 sucrose and acacia or tragacanth; pastilles comprising the active ingredient in an inert base such as gelatine and glycerine or sucrose and acacia; and mouthwashes comprising the active ingredient in a suitable liquid carrier. The compounds of the invention may be formulated for administration as suppositories. A low melting wax, such as a mixture of fatty acid glycerides or cocoa butter is first melted and 20 the active component is dispersed homogeneously, for example, by stirring. The molten homogeneous mixture is then poured into convenient sized molds, allowed to cool, and to solidify. The compounds of the invention may be formulated for vaginal administration. Pessaries, tampons, creams, gels, pastes, foams or sprays containing in addition to the active ingredient 25 such carriers as are known in the art to be appropriate. The subject compounds may be formulated for nasal administration. The solutions or suspensions are applied directly to the nasal cavity by conventional means, for example, with a dropper, pipette or spray. The formulations may be provided in a single or multidose form. In the latter case of a dropper or pipette, this may be achieved by the patient administering an 30 appropriate, predetermined volume of the solution or suspension. In the case of a spray, this may be achieved for example by means of a metering atomizing spray pump. The compounds of the invention may be formulated for aerosol administration, particularly to the respiratory tract and including intranasal administration. The compound will generally have a small particle size for example of the order of five (5) microns or less. Such a 35 particle size may be obtained by means known in the art, for example by micronization. The active ingredient is provided in a pressurized pack with a suitable propellant such as a chlorofluorocarbon (CFC), for example, dichlorodifluoromethane, trichlorofluoromethane, or 68 dichlorotetrafluoroethane, or carbon dioxide or other suitable gas. The aerosol may conveniently also contain a surfactant such as lecithin. The dose of drug may be controlled by a metered valve. Alternatively the active ingredients may be provided in a form of a dry powder, for example a powder mix of the compound in a suitable powder base such as lactose, starch, starch derivatives 5 such as hydroxypropylmethyl cellulose and polyvinylpyrrolidine (PVP). The powder carrier will form a gel in the nasal cavity. The powder composition may be presented in unit dose form for example in capsules or cartridges of e.g., gelatine or blister packs from which the powder may be administered by means of an inhaler. When desired, formulations can be prepared with enteric coatings adapted for sustained 10 or controlled release administration of the active ingredient. For example, the compounds of the present invention can be formulated in transdermal or subcutaneous drug delivery devices. These delivery systems are advantageous when sustained release of the compound is necessary and when patient compliance with a treatment regimen is crucial. Compounds in transdermal delivery systems are frequently attached to an skin-adhesive solid support. The compound of 15 interest can also be combined with a penetration enhancer, e.g., Azone (1 dodecylazacycloheptan-2-one). Sustained release delivery systems are inserted subcutaneously into the subdermal layer by surgery or injection. The subdermal implants encapsulate the compound in a lipid soluble membrane, e.g., silicone rubber, or a biodegradable polymer, e.g., polylactic acid. 20 The pharmaceutical preparations may be in unit dosage forms. In such form, the preparation is subdivided into unit doses containing appropriate quantities of the active component. The unit dosage form can be a packaged preparation, the package containing discrete quantities of preparation, such as packeted tablets, capsules, and powders in vials or ampoules. Also, the unit dosage form can be a capsule, tablet, cachet, or lozenge itself, or it can be the 25 appropriate number of any of these in packaged form. Other suitable pharmaceutical carriers and their formulations are described in Remington: The Science and Practice of Pharmacy 1995, edited by E. W. Martin, Mack Publishing Company, 19th edition, Easton, Pennsylvania. Representative pharmaceutical formulations containing a compound of the present invention are described below. 30 Utility The compounds of the invention are useful for treatment of LRRK2-mediated diseases or conditions, including neurodegenerative diseases such as Parkinson's disease, Lewy body dementia and Huntington's disease, and for enhancemenent of cognitive memory generally in subjects in need thereof. 35 Examples 69 The following preparations and examples are given to enable those skilled in the art to more clearly understand and to practice the present invention. They should not be considered as limiting the scope of the invention, but merely as being illustrative and representative thereof. Unless otherwise stated, all temperatures including melting points (i.e., MP) are in 5 degrees celsius ( 0 C). It should be appreciated that the reaction which produces the indicated and/or the desired product may not necessarily result directly from the combination of two reagents which were initially added, i.e., there may be one or more intermediates which are produced in the mixture which ultimately leads to the formation of the indicated and/or the desired product. The following abbreviations may be used in the Preparations and Examples. 10 LIST OF ABBREVIATIONS AcOH Acetic acid AIBN 2,2'-Azobis(2-methylpropionitrile) Atm. Atmosphere (BOC)20 di-tert-Butyl dicarbonate 15 DCM Dichloromethane/Methylene chloride DIAD Diisopropyl azodicarboxylate DIPEA Diisopropylethylamine DMAP 4-Dimethylaminopyridine DME 1,2-Dimethoxyethane 20 DMF N,N-Dimethylformamide DMSO Dimethyl sulfoxide DPPF 1,1 '-Bis(diphenylphosphino)ferrocene Et20 Diethyl ether EtOH Ethanol/Ethyl alcohol 25 EtOAc Ethyl acetate HATU 2-(1 H-7-Azabenzotriazol- 1 -yl)-- 1,1,3,3-tetramethyl uronium hexafluorophosphate Methanaminium 70 HBTU O-Benzotriazol-1-yl-N,N,N',N'-tetramethyluronium hexafluorophosphate HOBT 1 -Hydroxybenzotriazole HPLC High pressure liquid chromatography RP HPLC Reverse phase high pressure liquid chromatography 5 i-PrOH Isopropanol/isopropyl alcohol LCMS Liquid Chromatograph/Mass Spectroscopy MeOH Methanol/Methyl alcohol MW Microwaves NBS N-Bromosuccinimide 10 NMP 1-Methyl-2-pyrrolidinone PSI Pound per square inch RT Room temperature TBDMS tert-Butyldimethylsilyl TFA Trifluoroacetic acid 15 THF Tetrahydrofuran TLC Thin layer chromatography Preparation 1: 2-chloro-5-fluoro-N-methylpyrimidin-4-amine CI HN F ~ N MeNH 2 F MeOH N CI NICI To a 250mL round bottom flask equipped with a stir bar was added 9.Og 5-fluoro-2,4 20 dichloro-pyrimidine, 40mL methanol and 15mL of 8M methylamine in ethanol. The reaction heated up (mild exo-therm) and was allowed to stir at room temperature for -30 minutes. A check by TLC (1:1 EtOAc: heptane) and LCMS showed complete reaction. The reaction was concentrated down to give 9.77g crude material which was purified on a silica column running a gradient of 1% to 10% MeOH in DCM over 35 minutes to give 6.77 g pure 2-chloro-5-fluoro-N 25 methylpyrimidin-4-amine.

71 The same method was used to make the compounds shown in Table 1 below, using the appropriate commercially available substituted 2,4-dichloro-pyrimidines and amines. HN 1 2-chloro-5-chloro-N-methylpyrimidin-4- C1 N amine N CI HN 2 2-chloro-5-bromo-N-methylpyrimidin-4- Br N amine N CI HN 3 2-chloro-5-trifluoromethyl-N-

F

3 C N methylpyrimidin-4-amine N CI HN 6 2-chloro-5-methoxy-N-methylpyrimidin-4- 70 N amine N CI N 8 2-chloro-5-fluoro-N,N-dimethylpyrimidin- F N 4-amine N CI 9 2-chloro-5-chloro-N-ethylpyrimidin-4- H N am ine C1 NICI 10 2-chloro-5-chloro-N-propylpyrimidin-4- HN am ine C 1 CI C"'N"CI 11 2-chloro-5-chloro-N-isopropylpyrimidin-4- C HN amine NN N CI 12 2-chloro-5-chloro-N-isobutylpyrimidin-4- HN am in e CC _ _ _ _ _ _ _ _ _ _ K 72 13 4-(2,5-dichloropyrimidin-4-yl)morpholine N NICI

NH

2 14 2,5-dichloropyrimidin-4-amine

C

N C 152,5-dichloro-N,N-dimethylpyrimidin-4 amine NICI 16 4-(azetidin-1-yl)-2,5-dichloropyrimidineN NICI 17 2,5-dichloro-4-(pyrrolidin-1-yl)pyrimidine C"'~ N C 18 2,5-dichloro-4-(piperidin-1-yl)pyrimidine C N 19 2,5-dichloro-4-(2- N (methoxymethyl)piperidin-1 -yl)pyrimidine CI

N

N I 20 2, 5-dichloro-4-(4 20(methoxymethyl)piperidin- 1 -yl)pyrimidine N C'N 'Cl 212,5-dichloro-N- c (cyclopropylmethyl)pyrimidin-4-amine 22 2,5-dichloro-N- C"" (cyclobutylmethyl)pyrimidin-4-amine I NIC 73 2,5-dichloro-N- C1 23 (cyclopentylmethyl)pyrimidin-4-amine 24 2-chloro-N-methylpyrimidin-4-amineN N CI HN O 25 2,5-dichloro-N-(2-methoxyethyl)pyrimidin- CI N 4-amine ___ ___ ___ __ ___ ___ __ ___ ___ __N CI Table 1 Preparation 2: 2,5-dichloro-4-methoxypyrimidine CI O CI NaOMe CI N CI Et 2 O N CI To a 250 mL round bottom flask equipped with a stir bar was added 1 g 5-chloro-2,4 5 dichloro-pyrimidine, and l5mL of diethyl ether. The mixture was cooled to 0 0 C in an ice bath and then 1 equivalent of sodium methoxide in methanol (prepared from reacting 120 mg of sodium with 4 mL of methanol at room temperature) was slowly added. The reaction was stirred over night at room temperature and checked by LCMS. The white precipitate was filtered and the solid washed with cold methanol. After drying, 0.98 g of pure 2,5-dichloro-4 10 methoxypyrimidine was obtained and this material was used without further purification. The same method was used to make thecompounds shown in Table 2 below, using the appropriate commercially available alcohols and the appropriately substituted 2,4-dichloro pyrimidines. 2,5-dichloro-4-ethoxypyrimidine 2 2,5-dichloro-4-propoxypyrimidine 0 CI CI 74 3 2,5-dichloro-4-isoprpoxypyrimidine 0 INC N C 5-bromo-2-chloro-4- 0 6 methoxypyrimidine Br C 0 7 2-chloro-5-iodo-4- N methoxypyrimidine N Table 2 Preparation 3: 4-(5-fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxybenzoic acid HN 0 HN 4-amino-3-methoxybenzoic acid F N n-BuOH, MW, OH F N 120'C, 40 min N NN N CI H A mixture of 50 mg 2-chloro-5-fluoro-N-methylpyrimidin-4-amine, 57 mg 4-Amino-3 5 methoxybenzoic acid, 0.ImL 4N HCl in 1,4-dioxane and 1 mL N-butanol was placed in a 1OmL snap-top microwave vial (CEM Corp.) and heated to 120 0 C microwave for 40 min. The reaction was monitored by LC/MS. The precipitated solid was filtered to yield 80 mg of 4-(5-fluoro-4 (methylamino)pyrimidin-2-ylamino)-3-methoxybenzoic acid. The same method was used to make the compounds shown in Table 3 below, using the 10 appropriate amines and the appropriately substituted 2-chloropyrimidines. HN O 4-(5-chloro-4- C N OH 1 (methylamino)pyrimidin-2 ylamino)-3-methoxybenzoic acid N N H O HN 0 4-(5-chloro-4- c1 2 (methylamino)pyrimidin-2- N OH ylamino)benzoic acid N 'Ne H HN 0 3-methoxy-4-(5-methoxy-4-

-

OH 3 (methylamino)pyrimidin-2 ylamino)benzoic acid N N

HO

75 4-(5-chloro-4-propoxypyrimidin- CI N OH 5 2-ylamino)-3-methoxybenzoic | acid N N H 4-(5-chloro-4- cl 7 isopropoxypyrimidin-2- C N OH ylamino)-3-methoxybenzoic acid N HO O 0 4-(5-chloro-4- C1 N 8 methoxypyrimidin-2-ylamino)- | N OH 3-methoxybenzoic acid N N H HN 0 4-(5-bromo-4- Br OH 10 (methylamino)pyrimidin-2 ylamino)-3-methoxybenzoic acid N N H O 0 4-(5-bromo-4- Br N OH 11 methoxypyrimidin-2-ylamino)- N 3-methoxybenzoic acid N N H 0 HN 0 3-methoxy-4-(4- ,N OH 12 (methylamino)pyrimidin-2- | ylamino)benzoic acid N N H 1O

N

0 0 4-(5-iodo-4-methoxypyrimidin- I N OH 13 2-ylamino)-3-methoxybenzoic | acid N N H 4-(5-cyano-4-methoxypyrimidin- N ,, ''NOH 14 2-ylamino)-3-methoxybenzoic acid N' N H O1 HN 0 N 4-(5-cyano-4-methoxypyrimidin- OH 15 2-ylamino)-3-methoxybenzoic | OH acid NIN H Os Table 3 76 Preparation 4: 4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-3 (difluoromethoxy)benzoic acid

ICHF

2 0 DMF 0 Pd/C Cs 2

CO

3

H

2 , EtOH O O2N 0 2 N OH 0 F F 2,5-dichloro-N- LiOH methylpyrimidin-4-amine HN O water HN O , CI N THF CI OH H O YF H O F F F To a cooled solution of Ig of methyl-3-hydroxy-4-nitrobenzoate, 3.31g of cesium 5 carbonate in 20mL of DMF, was carefully added 1.5 equivalents of difluoroiodomethane. The reaction was allowed to warm to room temperature and followed by TLC. Upon completion of the reaction, the mixture was concentrated and purified by silica get chromatography to give 1.2g of methyl 3-(difluoromethoxy)-4-nitrobenzoate. Methyl 3-(difluoromethoxy)-4-nitrobenzoate (0.9 g) was placed in a 250 mL round 10 bottom flask and dissolved in 30mL of ethanol. Pd/C (0.15 g, 10% Pd) was carefully added and a balloon of hydrogen was attached to the flask. The reaction was vigorously stirred over night. After checking by TLC, the reaction was filtered through a pad of celite and concentrated to give 0.6 g of methyl 4-amino-3-(difluoromethoxy)benzoate which was used without further purification. 15 Methyl 4-amino-3-(difluoromethoxy)benzoate (70 mg), 2,5-dichloro-N-methylpyrimidin 4-amine, 0.1 mL of 4N HCI/dioxane and 1 mL of n-butanol were placed in a microwave vial. The reaction was heated for 30 minutes at 150'C and monitored by LCMS. The mixture was concentrated and purified by silica gel chromatography to give 100mg of pure methyl 4-(5 chloro-4-(methylamino)pyrimidin-2-ylamino)-3-(difluoromethoxy)benzoate. 20 Methyl 4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-3-(difluoromethoxy)benzoate (500 mg) was dissolved in 5mL of THF and 5 mL of water. After dissolution, 234 mg of lithium hydroxide was added and the reaction was stirred at room temperature over night. The mixture was checked by LCMS and then carefully acidified with IN HCl and partitioned with ethyl acetate. The organic layer was concentrated and purified by silica gel chromatography to give 25 250 mg of 4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-3-(difluoromethoxy)benzoic acid. Similarly made were: 77 4-(5-chloro-4- NH 0 1 (methylamino)pyrimidin-2- cl N OH ylamino)-3-ethoxybenzoic NIN acid H 4-(5-chloro-4- NH 0 (methylamino)pyrimidin-2- CI N / OH ylamino)-3-

I

cyclobutoxybenzoic acid N N H O 4-(5-chloro-4- NH 0 (methylamino)pyrimidin-2- CI N / OH ylamino)-3-(2,2,2- NZ1 3 trifluoroethoxy)benzoic acid N N H O I F F F Example 1 (4-(5-fluoro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxyphenyl) (morpholino)methanone HN 0 HN 0 F , N ~OH morpholine F , N N N N HATU, N P 0N H DIPEA, DMF H 5 A mixture of 100 mg 4-(5-fluoro-4-(methylamino)pyrimidin-2-ylamino)-3 methoxybenzoic acid, 47 tL morpholine, 205 mg HATU, 188 mL diisopropylethylamine in 1mL of dimethylformamide was stirred at room temperature overnight. The reaction was checked by LCMS and found to be complete. The reaction was diluted with EtOAc, and the organic layer washed with saturated NaHCO3 and brine. The organic layer was concentrated and purified by 10 preparative reverse phase HPLC to yield 12 mg of (4-(5-fluoro-4-(methylamino)pyrimidin-2 ylamino)-3-methoxyphenyl)(morpholino)methanone. Compounds made using the above procedure are shown inTable 4 below, together with proton NMR, and LRRK2 Ki (micromolar) data for selected compounds determined from the assay described below. Ex. Name Structure 'H NMR Ki 78 Ex. Name Structure 'H NMR Ki [4-(5-Fluoro-4- 'H NMR (400 MHz, methylamino- NH DMSO) o 8.46 (d, 1 H), pyrimidin-2- F N NIt N 7.89 (d, 1H), 7.56 (d, 0.070 1 ylamino)-3- 2H), 7.04 (s, 1 H), 7.00 8 methoxy-phenyl]- N N (d, 1H), 3.90 (s, 3H), morpholin-4-yl- H O 3.58 (d, 4H), 3.52 (s, methanone 3H), 2.90 (t, 3H) 'H NMR (400 MHz, methymo- DMSO) o 8.43 (d, 1 H), meyamin- NH 0 7.89 (d, 1H), 7.55 (d, pyimiin)-2-F NN 2H), 7.00 (s, 1 H), 6.96 0.044 2 methoxy-phenyl]- (d, 1H), 4.77 (d, 1H), 6 ]N N OH 3.90 (s, 3H), 3.73 (dd, (4-hydroxy- H piperidin-1-yI)- H o 2H), 3.23 - 3.12 (m, methanone 2H), 2.89 (d, 3H), 1.74 (s, 2H), 1.36 (d, 2H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NH DMSO) o 8.41 (d, 1 H), pyrimidin-2- ci N N 7.96 (s, 1H), 7.68 (s, 0.004 3 ylamino)-3- I " 1H), 7.32 (d, 1H), 7.05 methoxy-phenyl]- Nl N N (s, 1H), 7.01 (d, 1H), morpholin-4-yl- H o 3.90 (s, 3H), 3.56 (d, methanone 8H), 2.90 (t, 3H). 4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NH DMSO) 6 8.39 (d, 1 H), pyrimidin-2- Ci N / 7.96 (s, 1H), 7.67 (s, 0.006 4 ylamino)-3- 1H), 7.31 (d, 1H), 7.05 1 methoxy-N,N- N N (s, 1H), 7.00 (d, 1H), dimethyl- H o 3.87 (d, 3H), 2.97 (s, benzamide 6H), 2.91 (d, 3H). 'H NMR (400 MHz, 4-(5-Chloro-4- DMSO) 6 8.43 (d, 1 H), methylamino- NH 8.28 (s, 1H), 7.97 (s, pyrimidin-2- CI NN H 1H), 7.70 (s, 1H), 7.46 0.002 5 ylamino)-N- (d, 2H), 7.35 (d, 1H), 4 cyclopropyl-3- NN 3.93 (s, 3H), 2.91 (d, methoxy- H 3H), 2.82 (d, 1H), 0.75 benzamide - 0.62 (m, 2H), 0.56 (d, 2H). 1 H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.38 (d, 1 H), methylamino- NH 7.96 (s, 1H), 7.67 (s, pyrimidin-2- 1H), 7.31 (d, 1H), 7.01 6 ylamino)-3- N N (s, 1H), 6.96 (d, 1H), 0.017 methoxy-phenyl]- N " -N OH 4.77 (d, 1H), 3.88 (d, 3 (4-hydroxy- H 3H), 3.73 (d, 2H), 3.18 piperidin-1-yl)- /0 (t, 2H), 2.91 (d, 3H), methanone 1.74 (s, 2H), 1.36 (d, 2H). [4-(5-Chloro-4- NH 1 H NMR (400 MHz, methylamino- c N N DMSO) 6 8.34 (d, 1 H), 7 yamiIn-3 N 8.07 (s, 1H), 7.95 (s, 00049 7 ylamino)-3- 0 004 HfuoeoyN 1H), 7.29 (ddd, 3H), difluoromethoxy- H F 3.56 (d, 8H), 2.98 phenyl]-morpholin- 2.83 (m, 3H). ___ 4-yI-methanone F______________ __________ 79 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.40 (d, 1 H), methylamino- 7.96 (s, 1H), 7.67 (s, pyrimidin-2- NH 0 1H), 7.32 (d, 1H), 7.02 ylamino)-3- Ci N (d, 1H), 6.97 (dd, 1H), 0.003 8 methoxy-phenyl]- | 3.91 (d, 3H), 2.91 (d 5 (octahydro- N N 3H), 2.81 - 2.61 (m, pyrido[1,2- H 1O 3H), 2.12 - 1.89 (m, a]pyrazin-2-yl)- 2H), 1.81 (t, 1H), 1.76 methanone 1.36 (m, 4H), 1.34 0.97 (m, 2H). 1 H NMR (400 MHz, [4-(5-Chloro-4- DMSO) 5 8.38 (d, 1 H), methylamino- NNH 0 OH 7.96 (s, 1H), 7.67 (s, pyrimidin-2- c H), 7.31 (d, IH), 7.04 ylamino)-3- N N (s, 1H), 6.98 (d, 1H), 0.002 methoxy-phenyl]- NIN . 4.91 (s, 1H), 3.91 (d, 8 (2-hydroxy- H 3H), 3.51 (s, 2H), 3.11 piperidin-1-yl)- 0 (s, 1H), 2.91 (d, 3H), methanone 1.86 (s, 1H), 1.70 (s, 1H), 1.41 (s, 2H). 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.38 (d, 1 H), methylamino- 'NH 7.96 (s, 1H), 7.67 (s, pyrimidin-2- 1H), 7.31 (d, 1H), 6.98 ylamino)-3- N N (d, 1H), 6.94 (d, 1H), 0.003 10 methoxy-phenyl]- N N 3.89 (s, 3H), 3.39 (d, 7 (4,4-dimethyl- H 1H), 3.24 (d, 2H), 2.91 piperidin-1-yl)- (d, 3H), 1.54 (s, 2H), methanone 1.44 - 1.33 (m, 2H), 0.87 (s, 6H). 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.38 (d, 1 H), methylamino- NH 7.96 (s, 1H), 7.67 (s, pyrimidin-2- 1H), 7.31 (d, 1H), 7.00 11 ylamino)-3- N N (d, 1 H), 6.99 - 6.91 (m, 0.006 methoxy-phenyl]- N N 1H), 3.91 (d, 3H), 2.90 2 (3,5-dimethyl- H (d, 3H), 1.95 - 1.71 (m, piperidin-1-yl)- /o 2H), 1.67 - 1.49 (m, methanone 2H), 1.43 (t, 1 H), 1.00 0.68 (m, 7H). 'H NMR (400 MHz, methyairo-4- DMSO) o 8.38 (d, 1 H), pyrimidin-2- NH 7.96 (s, 1H), 7.67 (s, CImio)3 1 N H), 7.31 (d, 1 H), 7.01 12 yemox-phenyl]- N (d, 1H), 6.96 (dd, 1H), 0.001 [4-(1-hydroxy-l- N-K N 'K 4.14 (s, 1H), 3.90 (s, 7 methyl-ethyl)- H O OH 3H), 2.91 (d, 3H), 1.71 miehyl-thyl- (s, 2H), 1.44 (t, 1 H), pe hiron- 1.24 - 1.08 (m, 2H), 1.04 (s, 6H).

80 Ex. Name Structure 'H NMR Ki [4-(5-Chloro-4- 'H NMR (400 MHz, methylamiro - NH0DMSO) o 8.40 (d, 1 H), meyamin- NHAO 7.97 (s, 1H), 7.68 (s, ylamino)-3- ON~ NN-H 1 H), 7.32 (d, 1 H), 7.14 0.004 13 Ieoxyphenyl]- (d, 2H), 4.9 7 (s, 1 H), mehoyphnN] N"[: : 4.28 (d, 1IH), 3.92 (d, (3-hydroxy- H pyrrolidin-1-yI)- 0 3H), 3.72 - 3.39 (m, methanone 3H), 2.90 (t, 3H), 1.89 (dd, 2H). [4-(5-Chloro-4- H NMR (400 MHz, methylamino- NH 0 DMSO) 6 8.38 (d, 1 H), pyrimidin-2- 7.95 (s, 1H), 7.66 (s, ylamino)-3- N N 1H), 7.31 (d, 1H), 7.00 0.002 methoxy-phenyl]- (d, 1H), 6.95 (dd, 1H), 8 (4-methyl- H 3.91 (d, 3H), 2.91 (d, piperidin-1-yl)- 4H), 1.62 (d, 3H), 1.08 methanone (q, 2H), 0.94 (t, 3H). [4-(5-Chloro-4- N'H NMR (400 MHz, methylamino- NH 0 DMSO) 6 8.38 (d, 1 H), 7.96 (s, 1H), 7.66 (s, pyrimidin-2- c N- No 1H), 7.31 (d, 1H), 7.00 0.002 15 ylamino-henyl]- N: k N (d, 1H), 6.95 (dd, 1H), 5 mehoxy-pheyl- H 3.89 (s, 3H), 3.41 (d, pehiron 4H), 2.91 (d, 3H), 1.62 (d, 2H), 1.51 (s, 4H). Azetidin-1-yl-[4-(5-

N

1 H NMR (400 MHz, A n-1y4-- NNH 0 DMSO) 6 8.44 (d, 1 H), chloro-4 cl 7.97 (s, 1H), 7.70 (s, meyamin- N No 1H), 7.34 (d, 1H), 7.26 0.005 16 pyrmdn-2- N - 7.20 (m, 2H), 4.35 (s, 2 ylamino)-3- I J; methoxy-phenyl]- H 2H), 4.03 (s, 2H), 3.91 methadone (s, 3H), 2.91 (d, 3H), metanne2.30 - 2.20 (m, 2H). [4-(5-Chloro-4- 1 H NMR (400 MHz, methylamino- NNH DMSO) 6 8.41 (d, 1 H), pyrimidin-2- 7.96 (s, 1H), 7.68 (s, ylamino)-3- N N 1H), 7.33 (d, 1H), 7.09 0.003 17 methoxy-phenyl]- N N NIN F (d, 1H), 7.04 (dd, 1H), 0 (4,4-difluoro- H F 3.91 (s, 3H), 3.60 (s, piperidin-1-yl)- -0 4H), 2.91 (d, 3H), 2.11 methanone - 1.97 (m, 4H). 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.38 (d, 1 H), methylamino- NNH 0 7.96 (s, 1H), 7.67 (s, pyrimidin-2- 1H), 7.31 (d, 1H), 7.00 0.004 18 ylamino)-3- N N (d, 1H), 6.95 (dd, 1H) 5 methoxy-phenyl]- N N 3.89 (s, 3H), 2.90 (d, (3-methyl- H 3H), 1.78 (d, IH), 1.70 piperidin-1-yl)- - 1.50 (m, 2H), 1.42 (d, methanone 1H), 1.22 - 1.08 (m, 1H), 0.84 (s, 3H).

81 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.39 (d, 1 H), methylamino- NH 0 7.96 (s, 1H), 7.67 (s, pyrimidin-2- 1H), 7.31 (d, 1H), 7.02 19 ylamino)-3- NN (d, 1H), 6.97 (dd, 1H), 0.002 methoxy-phenyl]- N N O -. * K' . 3.90 (s, 3H), 3.49 - 9 (4-methoxy- H 0 3.39 (m, 2H), 3.26 (s, piperidin-1-yl)- /- 3H), 3.22 (d, 2H), 2.91 methanone (d, 3H), 1.84 (s, 2H), 1.44 (d, 2H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NH 0 DMSO) 6 8.43 (d, 1 H), F 7.97 (s, 1H), 7.70 (s, pyrimidin-2- ci N N F 1H), 7.33 (d, 1H), 7.04 20 ylamino)-3- N N F - 6.96 (m, 2H), 3.90 (s, 0.002 methoxy-phenyl]- NN(s (3,3-difluoro- H 3H), 3.84 (s, 2H), 3.53 piperidin-1-yI)- -(s, 2H), 2.91 (d, 3H), methanone 2.18 - 2.01 (m, 2H), 1.70 (s, 2H). 'H NMR (400 MHz, 1-[4-(5-Chloro-4- DMSO) o 8.40 (d, 1 H), methylamino- NH 7.96 (s, 1H), 7.67 (s, 1 H), 7.32 (d, IH), 7.05 pyrimidin-2- ciI N (d, 1H), 6.99 (dd, 1H), 0.002 21 ylamino)-3- 3.89 (d, 3H), 3.72 (s, 7 rnethoxy-benzoyl]- NI N" H) .2-30 (n pipeidin-4-H 02H), 3.20 - 3.09 (m, piperidine-4- o 1H), 2.91 (d, 3H), 1.90 carbonitrile (s, 2H), 1.81 - 1.67 (m, 2H). 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.40 (d, 1 H), methylamino- NH 7.96 (s, 1H), 7.67 (s, pyrimidin-2- CI1H), 7.32 (d, IH), 7.05 22 y r d --. c N N (d, 1H), 7.00 (dd, 1H), 0.002 methoxy-phenyl]- NIN F 5.02 - 4.81 (m, 1 H), 1 (4-fluoro-piperidin- H F 3.90 (s, 3H), 3.68 1-yl)-methanone 3.37 (m, 4H), 2.91 (d, 3H), 2.00 - 1.80 (m, 2H), 1.73 (s, 2H).. [4-(5-Chloro-4- 4 H NMR (400 MHz, methylamino-' NH0 DMSO) 6 8.38 (d, 1 H), mety ami n - N~H0I 7.96 (s, 1IH), 7.67 (s, pyrmin -2- c N N 0 1H), 7.31 (d, 1H), 7.03 0.005 23 methoxy-phenyl]- (s, 1H), 6.97 (d, 1H), 6 NeN 3.90 (s, 3H), 3.41 (d, (3--ethoxy- H O 2H), 2.90 (d, 3H), 1.86 piperidin-1-y)- (s, 1H), 1.63 (d, 2H), methadone 1.42 (s, 1H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NH 0 DMSO) 6 8.40 (d, 1 H), pyrimiin-2-7.96 (s, 1 H), 7.67 (s, pyrimidin-2- i N N 1H), 7.32 (d, 1H), 7.02 0.002 24 ylain N--NN (d, 1 H), 6.97 (dd, 1H), 0 (4-ethyl-piperazin- H 3.90 (s, 3H), 3.50 (s, 1-yl)-methanone 4H), 2.91 (d, 3H), 2.35 (dd, 6H), 1.00 (t, 3H).

82 Ex. Name Structure 'H NMR Ki I -{4-[4-(5-Chloro- 'H NMR (400 MHz, 4-methylamino- NH DMSO) 6 8.42 (d, 1 H), pyrimidin-2- CI7.96 (s, 1H), 7.68 (s, pyrimin-2- I NN N 1H), 7.33 (d, 1H), 7.07 0.003 25 ylaminx benzoyl]- N NN (d, 1 H), 7.02 (dd, 1H), 4 piperazin-1-yl- H 3.91 (s, 3H), 3.51 (d, iean -1-I} - 8H), 2.91 (d, 3H), 2.02 ethanone (s, 3H). 1 H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.40 (d, 1 H), methylamino- NH F 7.96 (s, 1H), 7.69 (s, pyrimidin-2- 1H), 7.32 (d, 1H), 7.05 26 ylamino)-3- N (d, 1 H), 7.03 - 6.97 (m, 0.002 methoxy-phenyl]- N1N 1H), 3.90 (s, 3H), 2.97 8 (3-trifluoromethyl- H (d, 2H), 2.89 (t, 3H), piperidin-1-yl)- 2.67 (s, 1 H), 1.99 (d, methanone 1H), 1.72 (s, 1H), 1.65 - 1.44 (m, 2H). (4-tert-Butyl- 'H NMR (400 MHz, piperidin-1 I)-[4- sDMSO) o 8.38 (d, 1 H), (5-chloro-4- NH 0 7.96 (s, 1H), 7.67 (s, methylamino- c N 1H), 7.31 (d, 1H), 7.01 0.007 27 pyrimidin-2- 1(d, 1H), 6.96 (dd, 1H), yrimin-2 N H 3.89 (s, 3H), 2.92 (t, ehox-phenyl]- H O 3H), 1.67 (s, 2H), 1.33 methanone - 1.03 (m, 3H), 0.85 (s, 9H). [4-(5-Chloro-4- I H NMR (400 MHz, methylamino- NNH DMSO) 6 8.40 (d, 1 H), pyrimidin-2- 7.96 (s, 1H), 7.67 (s, 28 ylamino)-3- N > )AI N 1 H), 7.32 (d, 1H), 7.02 methoxy-phenyl]- N N N (d, 1H), 6.97 (dd, 1H), [4-(2-hydroxy- H O 4.42 (t, 1H), 3.90 (s, ethyl)-piperazin-1- OH 3H), 3.50 (dd, 6H), 2.91 _ yl]-methanone (d, 3H), 2.41 (t, 6H). H NMR (400 MHz, DMSO) 6 8.39 (d, 1 H), [4-(5-Chloro-4- 7.96 (s, 1H), 7.67 (s, methylamino- NH 1H), 7.32 (d, 1H), 7.11 pyrimidin-2- ci(s, 2H), 4.17 - 4.05 (m, 29 ylamino)-3- l N N 1H), 3.90 (s, 3H), 3.54 0.003 methoxy-phenyl]- NIN (s, 1 H), 3.48 - 3.36 (m, 8 (2-methyl- H 1H), 2.90 (t, 3H), 2.07 pyrrolidin-1-yl)- (td, 1H), 1.87 (s, 1H), methanone 1.70 (s, 1H), 1.59 1.46 (m, 1 H), 1.24 (s, 2H). [4-(5-Chloro-4- 1 H NMR (400 MHz, methylamino- DMSO) 6 8.38 (d, 1 H), meyamin- NH 0 7.96 (s, 1H), 7.66 (s, yimidno-2-ci NN 1H), 7.31 (d, 1H), 7.00 0.002 30 methoxy-phenyl]- (d, 1H), 6.95 (dd, 1H), me-hydoxyhetyl- NN 4.49 (t, 1H), 3.89 (s, 4-hydoxymehyl- O OH 3H), 3.28 (t, 2H), 2.91 piperidin-1-yl)- (d, 4H), 1.66 (s, 3H), methadone 1.09 (q, 2H).

83 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, methyairo-4- NH DMSO) 6 8.37 (d, 1 H), meyamin- 06 7.95 (s, 1H), 7.66 (s, ylarmind-2- C N N 1H), 7.30 (d, 1H), 6.98 0.002 31 (ethylphenyl]( H), 6.93 (dd, 1H) 2 31 ~ amno)-3-NI N '.4.39 (s, 1IH), 3.89 (s, 2 (2-methyl- H 4H), 2.97 (t, 1H), 2.90 piperidin-1-yl)- (d, 3H), 1.73 - 1.28 (m, methanone 6H), 1.20 (d, 3H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NH DMSO) 6 8.40 (d, 1 H), pyrimidin-2- ci N N 7.96 (s, 1H), 7.67 (s, 0.004 32 ylamino)-3- 1H), 7.32 (d, 1H), 7.18 7" methoxy-phenyl]- N N - 7.11 (m, 2H), 3.90 (s, pyrrolidin-1-yl- H 3H), 3.47 (d, 4H), 2.91 methanone (d, 3H), 1.83 (s, 4H). [4-(5-Chloro-4 methylamino- NH 1 H NMR (400 MHz, pyrimidin-2- DMSO) 6 8.43 (d, 1 H), ylamino)-3- N N7.97 (s, 1H), 7.69 (s, 0.003 33 methoxy-phenyl]- NIN '-NS 1H), 7.33 (d, 1H), 7.09 6 (4- H - 6.99 (m, 2H), 3.91 (s, methanesulfonyl- 0 3H), 3.62 (s, 4H), 3.17 piperazin-1-yl)- (s, 4H), 2.91 (d, 6H). methanone [4-(5-Chloro-4- 1 H NMR (400 MHz, methylamiro-4 DMSO) o 8.46-8.39 meyamin- NH 0 (m, 1 H), 7.95 (d, 1 H), yrimin-2- cl NN F 7.69 (s, 1 H), 7.33 (d, 0.005 34 y0io)3 Ii 1 H), 7.16 (dd, 2H), 3.91 34 methoxyphenyl]- cN FdH).10.5 N (s, 3H), 3.76 (dt, 1H), (3-riorometyl- ~3.60 (dd, 3H), 2.91 (d, pron- - 3H), 2.17 (s, 1H), 2.05 1.95 (m, 1 H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamiro-4 NNH DMSO) 6 8.40 (d, 1 H), mety ami n o- 7.95 (d, 1 H), 7.6 7 (s, pyrimidin-2- ci N 1H), 7.32 (d, 1H), 7.03 35 nyl - N N N (d, 1H), 6.98 (dd, 1H), 0.002 methoxy-phenyl]- HI"::: 3.9(,3),353s [4-(2,2,2-trifluoro- H 0389 (d, 3H), 3.52 (s, ethl)-ipeazi-1 F F F 4H), 3.28 - 3.13 (m, ethyl)-piperazin-1 - F 2H), 2.90 (t, 3H), 2.64 yl]-methanone (s, 4H). [4-(5-Bromo-4- N 1 H NMR (400 MHz, methylamino- NH DMSO) o 8.40 (d, 1 H), pyrimidin-2- Br N N 8.04 (s, 1H), 7.68 (s, 0.001 36 ylamino)-3- 1 1H), 7.14 (d, 1 H), 7.05 3 methoxy-phenyl]- N N (d, 1H), 7. 01 (dd, 1H), morpholin-4-yl- H 0 3.90 (s, 3H), 3.56 (d, methanone 8H), 2.90 (d, 3H). [4-(5-Chloro-4- NNH 0H NMR (400 MHz, methylamino- DMSO) o 8.41 (d, 1 H), 37 pyrimidin-2- Nl" N 7.96 (s, 1H), 7.68 (s, 0.005 ylamino)-3 N N 1H), 7.32 (d, 1H), 7.05 3 methoxy-phenyl]- H (d, 1H), 7.00 (dd, 1H), (2-methyl- /__ 3.90 (s, 3H), 3.79 (s, 84 Ex. Name Structure 'H NMR Ki morpholin-4-yl)- 1H), 3.48 (ddd, 2H), methanone 2.91 (d, 3H), 1.08 (s, 3H). [4-(5-Chloro-4- 4H NMR (400 MHz, methylamino- NNH 0 DMSO) 6 8.41 (d, 1 H), pyrimidin-2- 7.96 (s, 1H), 7.68 (s, 38 ylamino)-3- N N 1H), 7.32 (d, IH), 7.04 0.007 methoxy-phenyl]- N0N (d, 1H), 7.00 (dd, 1H), 0 (2,6-dimethyl- H 3.90 (s, 3H), 3.54 (ddd, morpholin-4-yl)- / 2H), 2.89 (t, 3H), 1.07 methanone (s, 6H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NNH DMSO) 6 8.41 (d, 1 H), pyrimidin-2- 7.96 (s, 1H), 7.68 (s, 39 ylamino)-3- " 1H), 7.32 (d, 1H), 7.01 0.005 methoxy-phenyl]- NKN O (dd, 2H), 3.90 (s, 3H), 5 (2,2-diethyl- H 3.69 - 3.36 (m, 6H), morpholin-4-yl)- 2.91 (d, 3H), 1.47 (d, methanone 4H), 0.75 (s, 6H). [4-(5-Chloro-4- OH 'H NMR (400 MHz, methylamino- NH 0 DMSO) 6 8.39 (d, 1 H), pyrimidin-2- Ci N N 7.96 (s, 1H), 7.67 (s, ylamino)-3- | 1 1H), 7.32 (d, 1H), 7.08 0.004 40 methoxy-phenyl]- N N O (s, 1H), 7.02 (d, 1H), 4 (3-hydroxymethyl- H O 4.92 (s, 1H), 3.90 (s, morpholin-4-yl)- 3H), 3.88 - 3.44 (m, methanone 6H), 2.91 (d, 3H). 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) 6 8.41 (d, 1 H), methylamino- NH 7.96 (s, 1H), 7.68 (s, pyrimidin-2- NH 1H), 7.32 (d, 1H), 7.06 41 ylamino)-3- N (d, 1H), 7.00 (dd, 1H), 0.004 methoxy-phenyl]- AN O 3.90 (s, 3H), 3.76 (d, 2 (2-isobutyl- H O 1H), 3.44 (dd, 3H), 2.91 morpholin-4-yl)- (d, 3H), 1.69 (s, 1H), methanone 1.36 (s, 1H), 1.18 (s, 1H), 0.86 (s, 6H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NH DMSO) 6 8.41 (d, 1 H), pyrimidin-2- 7.96 (s, 1H), 7.68 (s, 42 ylamino)-3- I N N OH 1H), 7.32 (d, IH), 7.06 0.004 methoxy-phenyl]- N0N O (d, 1H), 7.01 (dd, 1H), 8 (2-hydroxymethyl- H 4.78 (s, 1H), 3.90 (s, morpholin-4-yl)- 3H), 3.85 (d, 1H), 3.42 methanone (ddd, 4H), 2.91 (d, 3H). [4-(5-Chloro-4- NH 0 1 H NMR (400 MHz, methylamino- NH 0 DMSO) 6 8.44 - 8.37 pyrimidin-2- ci N / N6 (m, 1H), 7.96 (s, 1H), ylamino)-3- | 1 7.68 (s, 1H), 7.33 (d, 0.008 43 methoxy-phenyl]- N N O 1H), 7.04 (dd, 2H), 3.91 2 (3,3-dimethyl- H O (s, 3H), 3.73 - 3.63 (m, morpholin-4-yl)- 2H), 3.39 (d, 2H), 2.91 methanone (d, 3H), 1.41 (d, 6H).

85 Ex. Name Structure 'H NMR Ki [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- NNH 0 DMSO) 6 8.40 (d, 1 H), pyrimidin-2- 7.96 (s, 1H), 7.67 (s, 44 ylamino)-3- N N 1H), 7.32 (d, 1H), 7.02 0.002 methoxy-phenyl]- N N (d, 1H), 6.97 (dd, 1H), 3 (4-methyl- H 3.90 (s, 3H), 3.50 (s, piperazin-1-yl)- /0 4H), 2.89 (t, 3H), 2.31 methanone (s, 4H), 2.21 (d, 3H). 1 H NMR (400 MHz, methyairo- DMSO) o 8.39 (d, 1 H), mety ami n - NH 0 7.96 (s, 1 H), 7.67 (s, pyimidno-c- 1H), 7.32 (d, 1H), 0.001 45 methoxy-phenyl]- N (s, 1H), 6.97 (d, 1H), 1 NIN 3.90 (s, 3H), 3.44 (d, (4-isopropyl- H piperazin-1-yl)- H 4H), 2.91 (d, 3H), 2.74 methanone - 2.60 (m, IH), 2.44 (s, 4H), 0.97 (d, 6H). [4-(5-Bromo-4- 'H NMR (400 MHz, methoxy- 0 0 DMSO) o 8.38 (s, 1 H), pyrimidin-2- Br N 8.31 (s, 1 H), 8.15 (d, 0.003 46 ylamino)-3- 1 1H), 7.08 (d, 1 H), 7.02 methoxy-phenyl]- N N (dd, 1H), 3.98 (s, 3H), morpholin-4-yl- H 3.89 (s, 3H), 3.56 (d, methanone 8H). 'H NMR (400 MHz, methy airo-4- 'NH O DMSO) o 8.42 (d, 1 H), mety ami n - 7.96 (s, 1 H), 7.69 (s, pyrimidin-2- C1 N N 1H), 7.33 (d, 1H), 7.06 0.002 47 ylamino -henyl]- N N NH (d, 1 H), 7.05 - 7.00 (m, 8 piperazin-1 -yI- H 1H), 3.91 (s, 3H), 3.59 methadone ~(s, 4H), 2.97 (s, 4H), 2.90 (t, 3H). [4-(5-Chloro-4- 1H NMR (400 MHz, methylamino- NH 0 1 M 40Mz pyrimidin-2- NH DMSO) 6 8.30 (d, 1 H), ylamino)-3- c I N N 8.06 (s, 1H), 7.95 (s' 0.003 48 difluoromethoxy- N N OH 1H), 7.37 - 7.14 (m, 7 phenyl]-(4- H 0 F 3H), 3.74 (s, 2H), 2.88 hydroxy-piperidin- o (dd, 3H), 1.75 (s, 2H), 1-yl)-methanone F 1.37 (s, 2H). 1H NMR (400 MHz, DMSO) - 8.44 (d, J= 8.3 Hz, 1 H), 7.96 (s, [4-(5-Chloro-4- NH 0 1H), 7.65 (s, 1H), 7.33 methylamino- c N N (d, J= 4.5 Hz, 1H), 49 pyrimidin-2- |j1 1 7.04 (d, J= 1.4 Hz, 0.004 ylamino)-3-ethoxy- N N 1 H), 7.00 (d, J = 8.3 3 phenyl]-morpholin- H Hz, 1H), 4.16 (q, J= 4-yl-methanone 6.9 Hz, 2H), 3.55 (d, J = 35.7 Hz, 8H), 2.92 (d, J= 4.6 Hz, 3H), 1.45 1.33 (m, 3H).

86 Ex. Name Structure 'H NMR Ki [3-Methoxy-4-(4- 'H NMR (400 MHz, methylamino-5- F NH DMSO) o 8.31 (d, 1 H), trifluoromethyl- F N N 8.19 (s, 1H), 8.07 (s, 0.002 50 pyrimidin-2- F 1H), 7.21 (d, 1H), 7.07 ylamino)-phenyl]- NIN (s, 1H), 7.02 (d, 1H), morpholin-4-yl- H O 3.90 (s, 3H), 3.56 (d, methanone 9H), 2.92 (d, 3H). 'H NMR (400 MHz, 4-(5-Chloro-4- NH O DMSO) o 8.47 - 8.39 methylamino- (m, 1H), 7.97 (s, 1H), 51 pyrimidin-2- ' N . NH 2 7.83 (s, 1H), 7.69 (s, 0.005 ylamino)-3- N 1H), 7.51 (d, 2H), 7.32 methoxy- H (d, 1H), 7.16 (s, 1H), benzamide 3.93 (s, 3H), 2.92 (d, 3H). 1 H NMR (400 MHz, 4-(5-Chloro-4- NH 0 DMSO) o 8.46 - 8.41 methylamino- (m, 1 H), 8.30 (t, 1 H), 0.003 pyrimidin-2- NH 7.96 (d, 1H), 7.69 (s, 52 yN79 d H,76 s ylamino)-N-ethyl- N 1H), 7.48 (t, 2H), 7.32 1 3-methoxy- (d, 1H), 3.91 (d, 3H), benzamide 2.92 (d, 3H), 1.12 (t, 3H). 4- (5-Chloro-4- 'H NMR (400 MHz, methylamino- NH 0 DMSO) 6 8.44 (d, 1 H), pyrimidin-2- ci 8.03 (d, 1H), 7.97 (s, 53 ylamino)-N- N H), 7.69 (s, 1 H), 7.53 0.002 isopropyl-3- N5"N - 745 (mn, 2H), 7.32 (d, 0 methoxy- H 1H), 4.10 (dq, 1H), 3.94 benzamide (s, 3H), 2.92 (d, 3H), 1.17 (d, 6H). 'H NMR (400 MHz, DMSO) 6 8.43 (d, J= 4-(5-Chloro-4- NH O 8.2 Hz, 1 H), 8.27 (d, J methylamino- c= 4.2 Hz, 1 H), 7.97 (s, 4 tpyrimidin-2 NH 1 H), 7.69 (s, 1H), 7.46 0.010 ylamino)-3- I (d, J= 8.2 Hz, 2H), 4 NKN 7.32 (d, J= 4.2 Hz, methoxy-N- H 1 H), 6.48 (s, 1 H), 3.93 methyl-benzamide 0..O (s, 3H), 2.92 (d, J= 4.5 Hz, 3H), 2.78 (d, J 4.4 Hz, 3H). 1 H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.31 (s, 1 H), propoxy-pyrimidin- cI N N 8.26 (s, 1H), 8.13 (d, 2-ylamino)-3- | 1 1H), 7.07 (s, 1 H), 7.02 0.006 55 methoxy-phenyl]- NI N O 0 (d, 1H), 4.35 (t, 2H), 0 morpholin-4-yl- H O 3.88 (s, 3H), 3.56 (d, methanone 8H), 1.76 (d, 2H), 0.97 (t, 3H).

87 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [4-(5-Chloro-4- HN 0 DMSO) o 8.37 (d, 1 H), ethylamino- Nl 7-96 (s, 1 H), 7.66 (s, pyrimidin-2- N N 1H), 7.29 (t, 1H), 7.05 0.002 56 ylamino)-3- I N 0 (s, 1 H), 7.02 - 6.97 (m, methoxy-phenyl]- H 1H), 3.90 (s, 3H), 3.64 morpholin-4-yl- 3.48 (m, 7H), 3.48 methanone 3.40 (m, 2H), 1.17 (t, 3H). [4-(5-Chloro-4- -- 0 H NMR (400 MHz, methylamino- HN 0 DMSO) o 8.43 (d, 1 H), pyrimidin-2- cN N 7.96 (s, 1H), 7.68 (s, ylamino)-3- 1H), 7.31 (d, 1 H), 7.11 0.002 57 methoxy-phenyl]- NIN O (d, 2H), 3.92 (s, 3H), 5 (3-oxa-8-aza- H 3.67 (d, 2H), 3.59 (s, bicyclo[3.2.1]oct- 2H), 2.91 (d, 3H), 1.87 _ 8-yl)-methanone (s, 4H). [4-(5-Chloro-4- 0 H NMR (400 MHz, [-5hloyrom- cDMSO) 6 8.31 (s, 1 H), ethoxy-pyrimidin- NN8.25 (s, 1H), 8.14 (d, 0.007 58 mehy-henyl]- N N 1H), 7.08 (s, 1H), 7.02 7 morpholin-4-yl- H (d, 1H), 4.45 (q, 2H), methanone 3.89 (s, 3H), 3.56 (d, 8H), 1.36 (t, 3H). 1 H NMR (400 MHz, DMSO) 6 8.30 (s, 1 H), [4-(5-Chloro-4- 8.25 (s, 1H), 8.11 (d, J isopropoxy- 0 " 0= 8.2 Hz, 1 H), 7.43 pyrimidin-2- 7.32 (m, 1 H), 7.08 (d, J 59 yimidn-2- = 1.4 Hz, 1H), 7.02 (d, 0.013 yamino)-- N | J = 8.2 Hz, 1 H), 5.34 0 methoxy-phenyl]- N N O (dt, J= 12.3, 6.2 Hz, morpholin-4-yl- H 1H), 3.88 (s, 3H), 3.56 methadone (d, J = 38.0 Hz, 8H), 1.35 (d, J= 6.2 Hz, 6H). 'H NMR (500 MHz, DMSO) o 8.40 (d, 1 H), methya4i-ro-4- HN 0 7.95 (s, 1H), 7.66 (s, Nl> 1H), 7.29 (s, 1H), 7.02 pyimiin-2- N N (s, 1H), 6.98 (d, 1H), 0.002 60 methoxy-phenyl]- N N 3.91 (s, 3H), 3.83 - . ((S)-3-methyl- H 3.78 (m, 3H), 3.63 morpholin-4-yl)- 3.59 (m, 1 H), 3.57 methnone3.53 (m, 1 H), 3.42 methanone 3.34 (m, 2H), 2.91 (d, 3H), 1.26 (d, 3H); [4-(5-Chloro-4- 0 0 1 H NMR (400 MHz, yrtdn-2- ci"N N DMSO) 6 8.32 (s, 2H), 61 ylamino)-3- O 8.15 (d, 1H), 7.08 (d, 0.010 NN 1H), 7.02 (dd, 1H), 3.99 4 methoxy-phenyl]- H (s, 3H), 3.89 (s, 3H), morpholin-4-y- 3.56 (d, 8H). inethanone 88 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, methyairo-4- HN O DMSO) 6 8.44 (d, 1 H), myamiin-cl 7.97 (s, 1H), 7.70 (s, 62 p yrimi n-2 - N N 1H), 7.36 (d, 1 H), 62 pini-dhenyl]- N"N N 7.24 - 7.05 (m, 2H), 5 (2-oxa-5-aza- H 4.63 (dd, 3H), 3.93 (d, bicyclo[2.2.1]hept- 3H), 3.67 (ddd, 3H), biylo[2.2.h ep 2.91 (d, 2H), 1.83 (t, 5-yl)-methanone 2H). [4-(5-Chloro-4- 1 H NMR (400 MHz, methylamino- HN 0 DMSO) 6 8.40 (d, 1 H), pyrimidin-2- oN N 7.96 (s, 1H), 7.68 (s, 63 ylamino)-3- 1H), 7.34 (d, 1 H), 7.03 0.002 methoxy-phenyl]- NIN O (d, 1H), 6.98 (dd, 1H), 0 (8-oxa-3-aza- H 4.28 (s, 3H), 3.90 (s, bicyclo[3.2.1]oct- 3H), 2.91 (d, 3H), 1.72 3-yl)-methanone (d, 5H). 1 H NMR (500 MHz, [4-(5-Chloro-4- DMSO) o 8.40 (d, 1 H), th i HN 0 - 7.96 (s, 1H), 7.67 (s, myaimdno-2l 1H), 7.33 (d, 1H), 7.02 ylamino)-N N (d, 1 H), 6.9 7 (d, 1 H)' 0.004 64 0mh-p- N N O 3.90 (s, 3H), 3.84 - 2 methoxy-phenyl]- WN - d H):.7?d H) .0 ((R)-3-methyl- H 3.73 (m, 3H), 3.61 (d, morpholn-4-ylo 1 H), 3.54 (d, 1 H), methanone 3.42 - 3.35 (m, 2H), 2.90 (d, 3H), 1.25 (d, 3H) N-(3-Amino propyl)-4-(5- HN O chloro-4- cl N NH 65 methylamino- 0.002 6 pyrimidin-2- N3 ylamino)-3- H 0 methoxy- NH2 benzamide 1H NMR (400 MHz, [4-(5-Cyclopropyl- DMSO) h8.39 (d, J = 4-methylamino- HN 8.2, 1H), 7.93 (s, 1H), pyrimdin-- J 7.82 (s, 1IH), 7.07 (s, pyrimidin-2- NN 1 H), 7.02 (d, IH), 3.97 0.035 methoxy-phenyl]- N "N 0 (s, 3H), 3.91 (s, 3H), 9 morpholin-4-yl- H 3.56 (m, 8H), 1.80 methanone 1.71 (m, 1 H), 0.86 0.78 (m, 2H), 0.69 0.61 (m, 2H) 1 H NMR (400 MHz, [4-(5-Chloro-4- HN 0 DMSO) o 8.36 (d, 1 H), isobutylamino- cl 7-96 (s, 1 H), 7.68 (s, pyrimidin-2- N N H), 7.39 (s, 1H), 7.05 0.004 67 ylamino)-3- N 0 (s, 1H), 6.98 (d, 1H), 0 methoxy-phenyl]- H 3.90 (s, 3H), 3.68 morpholin-4-yl- 3.42 (m, 8H), 3.21 (t, methanone 3H), 1.98 (dt, 1H), 0.90 (d, 6H).

89 Ex. Name Structure 'H NMR Ki [4-(5-Chloro-4- HN H NM 8.36 (d,1 H), irmi - CI ~ N N 7.96 (s, 1H), 7.67 (s, 68 ylamino)-3- N 1H), 7.35 (dd, 1H), 7.05 0.001 6 Nmo-p- NN (s, 1H), 6.99 (d, 1H), 9 morpholin-4-y- 3.90 (s, 3H), 3.56 (d, methanone 8H), 1.68 - 1.51 (m, 2H), 0.90 (t, 3H). [4-(5-Chloro-4- 1 H NMR (400 MHz, isopropylamino- HN o DMSO) o 8.34 (d, 1 H), pyrimiin-2-7.97 (s, 1 H), 7.67 (s, 69 ylarmid-- C N N 1H), 7.05 (s, 1H), 7.00 0.007 69 ylmio)3-N.o (d, 1 H), 6.8 9 (d, 1 H), 2 methoxy-phenyl]- N N 4.38 _ 4.21 (m, 1H) morpholin-4-yI- H 43 .1(n ) methanone - l 3.90 (s, 3H), 3.56 (d, 8H), 1.22 (d, 6H). [4-(5-Chloro-4- 'H NMR (400 MHz, methylamino- DMSO) 6 8.42 (d, 1 H), pyrimidin-2- HN 7.97 (s, 1H), 7.69 (s, ylamino)-3- Ci "N N 1H), 7.33 (d, IH), 7.08 0.002 70 methoxy-phenyl]- N N (d, 1H), 7.03 (dd, 1H)' 2 (4- H 3.88 (d, 3H), 3.63 (d, cyclopropanecarb -10 0 8H), 2.91 (d, 3H), 1.97 onyl-piperazin-1- (s, 1 H), 0.81 - 0.66 (m, yl)-methanone 4H). [4-(5-Bromo-4- 1 H NMR (400 MHz, methylamino- DMSO) 5 8.38 (s, 1 H), pyrimidin-2- HN ~ 0MO 68.3 (s, 1 H), 1 d ylamino)-3- Br N 82 s H,81 d 71 methoxy-phenyl]- BHN NH), 7.04 (s, 1H), 6.98 0.002 [4-(1-hydroxy-1- N N N (d, 1H), 4.13 (s, 1H), 4 methyl-ethyl)- H0 HO 3.98 (s, 3H), 3.88 (s, piperidin-1 yl)- 3H), 1.42 (m, 2H), 1.18 ip methanone (m, 2H), 1.05(s, 6H) [4-(5-Bromo-4- 1 H NMR (400 MHz, methylamino- HN O DMSO) 6 8.39 (s, 1 HO, pyrimidin-2- Br F' 8.1(,1H,81 72 ylamino)-3- NN NQ>A - 8.1(,FH,81 0.006 methoxy-phenyl]- N Nd, 1H), 7.17 (0, 2H), H2" N! 3.99 (s, 3H), 3.90 (s, (3-trifluoromethyl- H O 3H), 3.77 (m, 1H), 3.62 pyrrolidin-1-yl)- (m, 3H) methanone I -[4-(5-Bromo-4- 1 H NMR (400 MHz, methylamino- HNI DMSO) 6 8.38 (s, 1 H), pyrimidin-2- Br N8.30 (s, 1 H),, 8.15 (d, 73 ylamino)-3- Br N N H), 7.08 (s, H), 7. 01 0.004 methoxy-benzoyl]- N' N 9 (d, sH), 3.98 (s, 3H), pprdn--H 1-N 3.89 (s, 3H), 3.15 (in, piperidine-4- 2H), 1.90 (m, 2H), 1.75 (m, 2H) 90 Ex. Name Structure 'H NMR Ki [4-(5-Bromo-4- 'H NMR (400 MHz, methylamino- HN0 DMSO) 6 8.4 (s, 1 H), pyrimidin-2- Br 8.35 (s, 1H), 8.2 (d, pyr mid n -BNN 1H ), 7.1 (s, 1H ), 6.99 0.002 74 m no-phenyl]- N] N- N (d, 1 H), 3.9 (s, 3H), 3.8 (4-cyclobutyl- H \-1 (s, 3H), 3.5 (m, 4H), (4-cyclobutyl- ~2.69 (m, 1 H), 2.25 (s, eazn- -n- 4H), 1.98 (m, 2H), 1.75 inethanone-4- (m, 2H), 1.62 (m, 2H) [4-(5-Bromo-4 methylamino- HN 0 pyrimidin-2- Br 75 ylamino)-3- N 0.003 methoxy-phenyl]- N8N 8 [4-(2,2,2-trifluoro- H ethyl)-piperazin-1- F F yl]-methanone 1 H NMR (400 MHz, [4-(5-Bromo-4- DMSO) 6 8.38 (s, 1 H), methylamino- HN 8.29 (s, 1H), 8.13 (d, J pyrimidin-2- Br N N = 8.2, 1 H), 7.05 (s, 1 H), 76 ylamino)-3- 6.99 (d, J= 8.2, 1H), 0.002 methoxy-phenyl]- N 'N o 3.98 (s, 3H), 3.88 (s, 4 (4-methoxy- H l 3H), 3.50 - 3.38 (m, piperidin-1-yl)- 1H), 3.26 (m, 4H), 1.85 methanone (m, 2H), 1.45 (m, 2H). "H NMR (400 MHz, [4-(5-Bromo-4- DMSO) o 8.38 (s, 1 H), methylamino- HN O 8.29 (d, J = 7.7, 1 H), yrimin-2- Br..8.14 (d, J = 8.2, 1IH), 0.005 77 methoxy-phenyl]- BoH 3 H = 8.3, 1IH), 4.54 (in, ((R)-3-hydroxy- 0 2H), 4.44 (m, 2H), 3.98 pyrrolidin-1-yl)- (s, 2H), 3.88 (s, 2H). methanone 'H NMR (400 MHz, [4-(5-Bromo-4- DMSO) 6 8.38 (s, 1 H), methylamino- HNI 0 8.29 (d, J = 7.7, 1 H), pyrimidin-2- Br NN 8.14 (d, J= 8.2, 1H), 78 ylamino)-3- " [:;) N 7.06 (s, 1H), 7.00 (d, J 0.008 methoxy-phenyl]- N O = 8.3, 1H), 4.54 (t, J= 0 (4-oxetan-3-yl- Ho 6.5, 2H), 4.44 (t, J = piperazin-1-yl)- 6.1, 2H), 3.98 (s, 2H), methanone 3.88 (s, 2H). 1H NMR (400 MHz, DMSO) - 8.47 (d, J= [4-(5-Chloro-4- HN 8.3 Hz, 1 H), 7.96 (s, methylamino- ci N 1 H), 7.61 (s, 1H), 7.33 79 yamin-3- 0 (d, J = 4.5 Hz, 1H), 0.015 N7liN 7.06 (s, 1H), 6.99 (d, J 6 isopropoxy- H = 8.3 Hz, 1 H), 4.73 (dt, phenyl]-morpholin- J= 12.0, 6.0 Hz, 1H), 4-yl-mnethanone 3.55 (d, J = 36.7 Hz, 8H), 2.93 (d, J = 4.6 91 Ex. Name Structure 'H NMR Ki Hz, 3H), 1.33 (d, J 6.0 Hz, 6H). 1 H NMR (400 MHz, DMSO) o 8.34 (d, J {4-[5-Chloro-4- 8.3 Hz, 1 H), 7.97 (s, (cyclopropylmethyl HNO 1H), 7.68 (s, 1H), 7.38 -amino)-pyrimidin- ci N N (s, 1 H), 7.05 (s, 1 H), 0.002 80 2-ylamino]-3- 6.99 (d, J= 8.2 Hz, 7 methoxy-phenyl}- N N 1H), 3.90 (s, 2H), 3.56 morpholin-4-yl- H O (d, J = 33.7 Hz, 8H), methanone 1.15 (s, 1H), 0.46 0.37 (m, 2H), 0.26 (d, J = 4.6 Hz, 2H). 'H NMR (400 MHz, DMSO) 6 8.35 (d, J 8.2 Hz, 1 H), 7.98 (s, [4-(5-Chloro-4- 1H), 7.68 (s, 1H), 7.35 cyclobutylamino- HN (d, J= 7.1 Hz, 1H), pyrimidin-2- 7.04 (dd, J = 11.1, 4.9 0.001 81 ylamino)-3- ci N N Hz, 2H), 4.52 (dd, J= 0 methoxy-phenyl]- 0 16.1, 7.9 Hz, 1H), 3.90 morpholin-4-yl- H (s, 3H), 3.56 (d, J= methanone 35.5 Hz, 8H), 2.26 (d, J = 2.9 Hz, 2H), 2.21 2.07 (m, 2H), 1.75 1.60 (m, 2H). 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) 6 8.18 (d, J methylamino- HN 0 8.3 Hz, 1 H), 7.95 (s, pyrimidin-2- ci N 1H), 7.86 (s, 1H), 7.32 0.028 82 ylamino)-3- N (d, J = 4.6 Hz, 1 H), 0 hydroxy-phenyl]- N N 6.92 - 6.80 (m, 2H), morpholin-4-yl- H OH 3.54 (d, J = 36.7 Hz, methanone 8H), 2.91 (d, J = 4.6 Hz, 3H). 'H NMR (400 MHz, [4-(5-Bromo-4- DMSO) 6 8.38 (s, 1 H), methoxy-0- 8.29 (s, 1H), 8.14 (d, J pyrimidin-2- Br = 8.2, 1H), 7.05 (d, J= 83 ylamino)-3- r N 1.4, 1H), 6.99 (d, J= 0.002 methoxy-phenyl]- N N-N 8.2, 1H), 3.98 (s, 3H), 5 (4-ethyl-piperazin- H 3.88 (s, 3H), 3.50 (s, 1-yl)-methanone 4H), 2.35 (m, 6H), 1.00 (t, J = 7.1, 3 H). 1 H NMR (400 MHz, [4-(5-Chloro-4- DMSO) 6 8.37 (d, J methylamino- HN F O 12.4 Hz, 1H), 8.01 (s, pyrimidin-2- Ci NN ') 1H), 7.74 (s, 1H), 7.42 0.005 84 ylamino)-2-fluoro- I I [ (d, J = 4.3 Hz, 1 H), 5 5-methoxy- NN 6.99 (d, J = 6.2 Hz, phenyl]-morpholin- H O H), 3.89 (s, 3H), 3.64 4-yl-methanone (m, 4H), 3.55 (m, 4H), 2.92 (d, J = 4.5 Hz, 92 Ex. Name Structure 'H NMR Ki 3H). 'H NMR (400 MHz, DMSO) 6 8.39 (s, 1 H), [4-(5-Bromo-4- 0 8.24 (s, 1H), 8.19 (d, J methoxy- Br = 8.3 Hz, 1H), 7.01 (d, pyrimidin-2- N N J= 8.2 Hz, 1H), 6.88 0002 85 ylamino)-3- N N (s, 1 H), 4.90 - 4.75 cyclobutoxy- H 1H), 4.00 (s, 3H), 3.55 phenyl]-morpholin- (m, 8H), 2.43 (m, 2H), 4-yl-methanone 2.21 - 2.04 (m, 2H), 1.80 (m, 1 H), 1.72 1.55 (m, 1 H). 'H NMR (400 MHz, DMSO) 6 8.44 (d, J= 8.3 Hz, 1 H), 7.96 (s, [4-(5-Chloro-4- HN 0 1H), 7.64 (s, 1H), 7.33 methylamino- ci(d, J = 4.5 Hz, 1 H), pyrimidin-2- NN 7.00 (d, J =8.3 Hz, 0.002 86 ylamino)-3- 0N N 1H), 6.86 (s, 1H), 8 cyclobutoxy- H 4.90 - 4.69 (m, 1 H), phenyl]-morpholin- 3.55 (m, 8H), 2.92 (d, J 4-yl-methanone = 4.6 Hz, 3H), 2.50 2.36 (m, 2H), 2.14 (m, 2H), 1.82 (m, 1H), 1.68 (m, 1 H). 1 H NMR (400 MHz, [4-(5-Chloro-4- DMSO) 6 8.34 (d, J ethylamino- HN F 0 12.5 Hz, 1H), 8.01 (s, pyrimidin-2- ci N N 1H), 7.73 (s, 1H), 7.43 0.002 87 ylamino)-2-fluoro- | (t, 1H), 6.99 (d, J= 6.2 5-methoxy- N N Hz, 1H), 3.89 (s, 3H), phenyl]-morpholin- H 0 3.59 (m, 8H), 3.49 4-yl-methanone 3.39 (m, 2H), 1.18 (t, 3H). 1H NMR (400 MHz, DMSO) 6 8.41 (s, 1 H), [4-(5-Bromo-4- 8.30 (s, 1H), 8.22 (d, J methoxy- 0 = 8.9, 1 H), 7.27 (d, J = pyrimidin-2- Br N 6.8, 2H), 4.36 (s, 2H), 88 ylamino)-3- | | 4.17 (s, 1H), 4.05 (s, 0.005 methoxy-phenyl]- N H N H), 3.99 (s, 3H), 3.91 0 (3-morpholin-4-yl- H 1110 (s, 3H), 3.88 (s, 1 H), azetidin-1-yl)- 3.59 (t, J = 4.4, 4H), methanone 3.19 - 3.09 (m, 2H), 2.33 (s, 5H). [4-(5-Chloro-4- 1H NMR (400 MHz, methylamino- HN- DMSO) 6 8.45 (d, J = pyrimidin-2- CI .8.2, 1H), 7.98 (s, 1H), pN 7.71 (s, 1H), 7.34 (dd, J 89 ylamino)-3- yI "N = 8.2, 4.1, 1H), 7.25 (d, 0.002 methoxy-phenyl]- H = 4.45 -) (3-morpholin-4-yl- H .o J = 9.3, 2H), 4.45 (3-inpin-4-y- A4.31 (m, 1 H), 4.23 azetidin-1-yl)- 4.11 (m, 1H), 4.02 (dd, methadone J = 14.9, 9.3, 1H), 3.92 93 Ex. Name Structure 'H NMR Ki (s, 3H), 3.86 (dd, J = 9.8, 7.5, 1H), 3.59 (t, J = 4.3, 3H), 3.17 - 3.08 (m, 1 H), 2.92 (d, J = 4.6, 3H), 2.32 (s, 4H). 1 H NMR (400 MHz, DMSO) o 8.36 (d, J 8.3 Hz, 1 H), 7.96 (s, [4-(5-Chloro-4- 1H), 7.68 (s, 1H), 7.05 cyclopentylamino- HN(d, J 1.5 Hz, 1H), pyrimdin-- HN'O 07.00 (d, J = 8.3 Hz, pyrimidin-2- cl N N"') 1H), 6.93 (d, J = 7.2 0.003 90 ylamino)-3- N N Hz, 1H), 4.36 (dd, J 9 methoxy-phenyl]- Nk N14.2, 7.1 Hz, 1H), 3.90 morpholin-4-yl- H (s, 3H), 3.56 (d, J= methadone 33.8 Hz, 8H), 1.97 (d, J = 11.7 Hz, 2H), 1.72 (s, 2H), 1.59 (m, J = 11.5, 7.5 Hz, 4H). 'H NMR (400 MHz, {4-[5-Chloro-4-(1- DMSO) 6 8.21 (d, J= methyl- 8.2 Hz, 1 H), 7.95 (s, cyclobutylamino)- HN O 1H), 7.65 (s, 1H), 91 pyrimidin-2- ci N N7.09 - 6.88 (m, 3H), 0.002 ylamino]-3- 3.88 (s, 3H), 3.56 (d, J 4 methoxy-phenyl}- N = 37.1 Hz, 8H), 2.32 (d, morpholin-4-yl- H O J= 11.8 Hz, 2H), 2.07 methanone (s, 2H), 1.78 (d, J= 6.7 Hz, 2H), 1.52 (s, 3H). 'H NMR (400 MHz, DMSO) 6 8.33 (d, J= 8.3 Hz, 1 H), 7.96 (s, [4-(5-Chloro-4- 1H), 7.70 (s, 1H), 7.05 cyclohexylamino- HN 98(d, J 1.4 Hz, 1H), pyrimdin-- HN O 06.98 (d, J = 8.3 Hz, 92 ylamino)-3- c"l) 1H), 6.86 (d, J= 7.8 0.006 92 pyamiino-3- N N Hz, 1H), 3.90 (s, 3H), 1 methoy-eyl]- N <N O 3.56 (d, J = 34.3 Hz, mohnoln--yI- H 8H), 1.83 (dd, J= 48.5, methadone O11.4 Hz, 4H), 1.65 (d, J = 12.7 Hz, 1 H), 1.48 1.22 (m, 4H), 1.14 (d, J = 12.6 Hz, 1H). 'H NMR (400 MHz, 0 DMSO) 6 8.33 (d, J= (4-{5-Chloro-4- 8.3 Hz, 1 H), 7.97 (s, [(tetrahydro-fu ran- 1H), 7.71 (s, 1H), 7.49 3-ylmethyl)- (s, 1 H), 7.05 (s, 1 H), 93 amino]-pyrimidin- HN 6.99 (d, J= 8.3 Hz, 0.014 2-ylamino}-3- ci N N 1H), 3.90 (s, 3H), 3.75 1 methoxy-phenyl)- (dd, J= 13.8, 7.9 Hz, morpholin-4-yl- N 1H), 3.67 - 3.44 (m, methanone H O 8H), 3.38 (t, J = 6.6 Hz, 2H), 2.63 (s, 2H), 1.93 (dd, J = 12.4, 5.8 Hz, 94 Ex. Name Structure 'H NMR Ki 2H), 1.63 (dd, J= 12.3, 5.4 Hz, 2H). [4-(5-lodo-4- HN 1H NMR (400 MHz, methylamino- HN DMSO) 6 8.46 (s, 1 H), pyrimidin-2- I N N 8.23 (s, 1H), 8.18 (d, 0.000 94 ylamino)-3- 1 H), 7.08 (s, 1H), 7.02 8 methoxy-phenyl]- N N (d, 1H), 3.95 (s, 3H), morpholin-4-yl- H 3.89 (s, 3H), 3.56 (m, methanone 8H) 1 H NMR (400 MHz, [sopropoxy- DMSO) 6 8.36 (s, 1 H), pyrimidin-2- Br8.26 (s, 1 H), 8. 10 (d, 95 NH), 7.08 (d, 1H), 7.02 0.003 th x-phenyl]- (dd, 1 H), 5.32 (sept, 9 mehoy-heyl-N

N..;.'

0 1H), 3.8 8 (s, 3 H), 3.66 morpholin-4-y- H - 3.44 (m, 8H), 1.34 (d, methanone 6H) 'H NMR (400 MHz, [4-(5-Bromo-4- 0 DMSO) 6 8.38 (s, 1 H), ethoxy-pyrimidin- Br 8.26 (s, 1 H), 8.13 (d, 96 2-ylamino)-3- NN 1 H), 7.08 (d, 1 H), 7.02 methoxy-phenyl]- N 0 (dd, 1H), 4.44 (q, 2H), morpholin-4-yl- H 3.88 (s, 3H), 3.70 methanone 3.43 (m, 8H), 1.36 (t, 3H) [4-(5-Bromo-4- 0 H NMR (400 MHz, methoxy- DMSO) 6 8.39 (s, 1 H), pyrimidin-2- Br 'N N0 8.30 (s, 1H), 8.16 (d, 98 ylamino)-3- F 1 H), 7.12 (s, 1H), 7.06 0.004 methoxy-phenyl]- N HN F (d, 1H), 3.98 (s, 3H), 5 (4,4-difluoro- H 3.89 (s, 3H), 3.61 (s, piperidin-1-yl)- 4H), 2.14 - 1.94 (m, methanone 4H) 'H NMR (400 MHz, DMSO) 6 8.32 (d, J= 8.3 Hz, 1 H), 7.98 (s, (4-{5-Chloro-4- 0 1H), 7.71 (s, 1H), 7.23 [(tetrahydro-furan- (t, J= 5.8 Hz, 1 H), 7.05 2-ylmethyl)- HN (d, J 1.4 Hz, 1H), amino]-pyrimidin- l 6.98 (d, J = 8.3 Hz, 99 2-ylamino}-3- N N H), 4.13 - 4.05 (m, Iehx-pey) l N 1H), 3.9 0 (s, 3 H), 3.78 methoxy-phenyl)N N O (dd, J= 13.9, 7.0 Hz, morpholin-4-yl- H 1 H), 3.65 - 3.47 (m, methanone 8H), 3.47 - 3.41 (m, 2H), 1.96 - 1.74 (m, 3H), 1.70 - 1.53 (m, 1 H). {4-[5-Chloro-4- 0 H NMR (400 MHz, (cyclobutylimethyl- HN DMSO) 6 8.36 (d, J= amino)-pyrimidin- C N N 8.3 Hz, 1 H), 7.95 (s, 100 2-ylamino]-3- | 1 1H), 7.67 (s, 1 H), 7.32 methoxy-phenyl}- NIN O (s, 1H), 7.05 (d, J= 1.5 morpholin-4-yl- H Hz, 1H), 6.98 (d, J = methanone 8.3 Hz, 1 H), 3.90 (s, 95 Ex. Name Structure 'H NMR Ki 3H), 3.56 (d, J = 34.2 Hz, 8H), 3.47 - 3.41 (m, 2H), 2.72 - 2.59 (m, 1 H), 1.98 (d, J = 8.3 Hz, 2H), 1.82 (dd, J = 13.9, 6.2 Hz, 2H), 1.74 (dd, J= 18.4, 7.4 Hz, 2H). [4-(5-lodo-4- 0 methoxy- 0 pyrimidin-2- N 0.002 101 ylamino)-3 methoxy-phenyl]- H N morpholin-4-yl- H 0 methanone 1H NMR (400 MHz, [4-(5-Cyclobutyl-4- HN 0 DMSO) o 8.39 (d, 1 H), methylamino- 7.93 (s, 1H), 7.82 (s, pyrimidin-2- ~N .~ N 1H), 7.07 (s, 1H), 7.02 102 ylamino)-3- Io .N (d, 1 H), 3.97 (s, 3H), 0.427 methoxy-phenylNN 3.91 (s, 3H), 3.56 (m, 5 morpholin-4-yl- 8H), 1.80 - 1.71 (m, methanone 1 H), 0.86 - 0.78 (m, 2H), 0.69 - 0.61 (m, 2H) 1H NMR (400 MHz, [4-(5-Cyclopropyl- HN 0 DMSO) 6 8.60 (d, 1H), 4-methylamino- 7.74 (s, 1H), 7.41 (s, pyrimidin-2- N N 1H), 7.03 (s, 1H), 7.00 103 ylamino)-3- : (d, 1H), 6.50 (d, J = 0.089 N o N 4.7, 1H), 3.91 (s, 3H), 5 methoxy-phenyl]- H 3.56 (m, 8H), 2.87 (d, morpholin-4-y- 3H), 2.35 - 2.27 (m, methadone 2H), 2.02 - 1.91 (m, 3H), 1.24 (s, 2H) 'H NMR (400 MHz, DMSO) o 8.36 (d, J= {4-[5-Chloro-4-(2- 8.3 Hz, 1 H), 7.95 (s, cyclppyl H1 H), 7.67 (s, 1 H), 7.31 ethylamino)- N (s, 1H), 7.05 (d, J= 1.4 pyrimidin-2- ci NHz, 1H), 6.99 (d, J = 0.001 104 . N N 8.2 Hz, 1H), 3.90 (s, 8 anieox-phenyl}- I N< o 3H), 3.65 - 3.43 (m, morpholin-4-yl- H 8H), 1.49 (dd, J= 14.6, methanone 7.1 Hz, 2H), 0.71 (s, 1 H), 0.47 - 0.34 (m, 2H), 0.06 (d, J = 3.8 Hz, 2H). {4-[5-Chloro-4-(2- 'H NMR (400 MHz, methoxy- HN-"- 0 DMSO) 6 8.32 (d, J ethylamino)- 8.3 Hz, 1 H), 7.98 (s, 105 pyrimidin-2- N N 1H), 7.71 (s, 1H), 7.24 0.009 ylamino]-3- NN O (d, J= 5.5 Hz, 1H), 4 methoxy-phenyl}- H 7.05 (s, 1H), 6.98 (d, J morpholin-4-yl- /-1= 8.2 Hz, 1H), 3.90 (s, methanone 3H), 3.66 - 3.45 (m, 96 Ex. Name Structure 'H NMR Ki 12H), 3.26 (d, J= 9.4 Hz, 3H). 'H NMR (400 MHz, DMSO) 6 8.37 (d, J {4-[5-Chloro-4- 8.3 Hz, 1 H), 7.95 (s, (cyclopentylmethyl 1H), 7.67 (s, 1H), 7.38 -amino)-pyrimidin- HN (t, J = 5.4 Hz, 1 H), 7.05 06-amino-yn - H(s, 1 H), 6.97 (d, J = 8.3 0.003 106 m ino-3- CyNN N- N Hz, 1H), 3.90 (s, 3H), 9 morpholin-4-yI- Ll-o 3.56 (d, J = 34.6 Hz, methanone H 8H), 2.35 - 2.24 (in, OH 0 1H), 1.73 - 1.44 (m, 6H), 1.29 (dd, J= 11.7, 7.1 Hz, 2H). [4-(5-Bromo-4 methoxy- - 0 pyrimidin-2- Br D ylamino)-3- N D 107 methoxy-phenyl]- N N O 0.002 ((R)-2,2-di- H deutero-3-methyl morpholin-4-yl) methanone 1 H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.40 (d, J= methylaino- HN O 8.3 Hz, 1 H), 7.96 (s, pyrimidin-2- Cl 1H), 7.65 (s, 1H), 7.34 108 ylamino)-3-(2,212- (d, J = 4.7 Hz, 1 H), 0.000 108 la or ' ')- N O0 7.23 (s, 1H), 7.12 (d, J 4 trifluoro-ethoxy)- NF=84H,1H,49 q H 84 Hz, 1 H), 4.92 (q, phenyl]-morpholin- O F J=8.8 4-ylmethnoneF J 8.8Hz, 2 H), 3.56 4-yl-methanone (m, 8H), 2.91 (d, J 4.5 Hz, 3H). [4-[5-Chloro-4-(2- 1 H NMR (400 MHz, methoxy- H o DMSO) 6 8.31 (d, J ethylamino)- 8.3 Hz, 1 H), 7.98 (s, Npyrimidin-2- N N 1H), 7.70 (s, 1H), 7.27 0.009 ylamino]-3-(2,2,2- 0 (m, 1H), 7.22 (s, 1H), 6 trifluoro-ethoxy)- H 0 F 7.09 (d, J = 8.3 Hz, phenyl]-morpholin- IF 1H), 4.92 (m, 2H), 3.52 4-yl-methanone (m, 12H), 3.26 (s, 3H). [4-(5-Bromo-4- H NMR (400 MHz, methoxy- 0 F 0 DMSO) 6 8.46 (s, 1 H), pyrimidin-2- Br N N 8.34 (s, 1H), 8.16 (d, J 0.011 110 ylamino)-2-fluoro- | |I= 12.0 Hz, 1H), 7.04 (d, 0 5-methoxy- N N J= 6.1 Hz, 1H), 4.01 phenyl]-morpholin- H O (s, 3H), 3.89 (s, 3H), _ 4-yl-methanone 3.60 (m, 8H). [4-(5-Bromo-4 methoxy- HN D pyrimidin-2- Ci N N D 111 ylamino)-3 methoxy-phenyl]- N N ((S)-2,2-di- H deutero-3-methyl- 97 Ex. Name Structure 'H NMR Ki morpholin-4-yl) methanone [4-(5-Chloro-4 methylamino- HN0 pyrimidin-2- c H ylamino)- 3 - I N N 112 methoxy-phenyl]- N N No [4-(1 -methyl- HN piperidin-4-yl) piperazin-1-yl] methanone [4-(5-Chloro-4- HN 0 methylamino pyrimidin-2- N 113 ylamino)-3 N N trifluoromethoxy- H F phenyl]-morpholin- -fF 4-yl-methanone F [4-(5-Cyclobutyl-4- 0 0 methoxy pyrimidin-2- N N 114 ylamino)-3- N N methoxy-phenyl]- H morpholin-4-yl methanone [3-Chloro-4-(5 chloro-4- HN 0 methylamino- cl N 115 pyrimidin-2- 0.006 ylamino)-phenyl]- NIN morpholin-4-yl- H CI methanone 1 H NMR (400 MHz, [4-(5-Bromo-4- o 0 DMSO) o 8.39 (s, 1 H), methoxy- Br 8.27 - 8.14 (m, 2H), 116 pyrimidin-2- N N7.11 - 6.94 (m, 2H), ylamino)-3-ethoxy N N O 4.15 (q, J= 7.0 Hz, phenyl]-morpholin- H 2H), 3.99 (s, 3H), 3.55 4-yl-methanone / (d, J = 37.7 Hz, 8H), 1.37 (t, J = 6.9 Hz, 3H). 1 H NMR (400 MHz, DMSO) o 8.64 (d, J [4-(5-Chloro-4- 6.7 Hz, 1 H), 8.47 (d, J methylamino- = 8.5 Hz, 1H), 7.98 (s, pyrimidin-2- 1H), 7.73 (s, 1H), yrlmidn)-3- 7.55 - 7.42 (m, 2H), 117 methoxy-phenyl]- N N 7.35 (d, J= 4.5 Hz, (3,3-iflu ro-H F 1H), 4.38 - 4.15 (m, (3,3-difluoro-H azetidin-1-yl)- 1H), 3.94 (s, 3H), methanone 3.00 -2.92 (m, 1 H), 2.93 (d, J = 5.0 Hz, 3H), 2.85 - 2.59 (m, 2H).

98 Ex. Name Structure 'H NMR Ki {4-[5-Bromo-4-(2- ' H NMR (400 MHz, methoxy- HN O 0 DMSO) 6 8.33 (d, J= ethylamino)- 8.3 Hz, 1 H), 8.06 (s, 118 ylmin)- Br,, N N-) 1H), 7.68 (s, 1H), 11 yrimin-2-th- I 0~j 7.07 - 6.93 (in, 3H), an]-3-ethoxy N 4.16 (q, J= 6.9 Hz, morphin-4-yl- H 2H), 3.69 - 3.38 (m, methanone 12H), 3.28 (s, 3H), 1.39 met(-h oe (t, J = 6.9 Hz, 3H). [4-(5-Chloro-4- 1 M 40Mz methylamino- HN ~ 0 1 H NMR (400 MHz, pyrimidin-2- HN DMSO) 6 8.39 (d, 1 H), 119 lamio)-3 Cl"7.96 (s, 1 H), 7.67 (s, 119 eoxyphenyl] N" N N N 1H), 7.31 (d, 1H), 7.05 (4-dimethylamino- H (s, 1H), 7.00 (d, 1H), piperidin-1-yl)- 3.87 (d, 3H), 2.97 (s, methanone 6H), 2.91 (d, 3H). 1 H NMR (400 MHz, DMSO) 6 8.93 (d, J 6.4 Hz, 1 H), 8.47 (d, J 4-(5-Chloro-4- HN = 8.4 Hz, 1H), 7.98 (s, methylamino- HN 0 1H), 7.73 (s, 1 H), 7.54 pyrimidin-2- CI N NH (d, J= 8.7 Hz, 1H), 120 ylamino)-3- 7.51 (s, 1H), 7.35 (d, J methoxy-N- NN = 4.6 Hz, 1H), 5.00 (dt, oxetan-3-yi- H 0 0 J= 13.9, 7.0 Hz, 1H), benzamide 4.78 (t, J = 6.9 Hz, 2H), 4.60 (t, J = 6.4 Hz, 2H), 3.95 (s, 3H), 2.92 (d, J = 4.5 Hz, 3H). 1 H NMR (400 MHz, DMSO) 6 8.45 (d, J= 8.5 Hz, 2H), 8.04 (d, J 4-(5-Chloro-4- H 0 = 7.6 Hz, 1H), 7.98 (s, methylamino- 1H), 7.71 (s, 1H), 7.50 pyrimidin-2- CI N NH (d, J= 8.7 Hz, 1H), 121 ylamino)-3- 7.47 (s, 1H), 7.35 (d, J methoxy-N- N N = 4.2 Hz, 1 H), 3.94 (s, (tetrahydro-pyran- H O 3H), 3.79 (t, 2H), 3.15 3-yl)-benzamide (t, 2H), 2.92 (d, J = 4.5 Hz, 3H), 1.91 (m, 1H), 1.70 (m, 2H), 1.63-1.58 m, 2H). H NMR (400 MHz, DMSO) 6 8.29 (s, 1 H), {4-[5-Chloro-4- .. 8.27 (s, 1H), 8.00 (s, (tetrahydro-pyran- 1H), 7.76 (s, 1H), 7.05 (tetrahyo-- HNJ 0 (s, 1 H), 6.98 (d, J = 8.3 3-ylamino)- H z, 1H), 6.82 (d, J = 122 pyrmino]-3- N N 8.0 Hz, 2H), 4.09 (m, ehoxy-phenyl}- N0N 2H) 3.90 (s, 3H), metoxypheyl} N'N 3.86 - 3.74 (in, 3H), morpholin-4-yl- H 3.56 (m, 8H), 3.46 mnethanone 3.11 (m, 64H), 1.93 (s, 1H), 1.77 - 1.52 (m, 3H).

99 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, DMSO) 6 8.35 (d, J {4-[5-Chloro-4-(2- 8.3 Hz, 1 H), 7.98 (s, methoxy- HN O 1H), 7.67 (s, 1H), 7.25 ethylamino)- (t, J= 5.2 Hz, 1 H), 6.97 pyrimidin-2- N N (d, J 8.3 Hz, 1H), 123 ylamino]-3- No 6.86 (s, 1 H), 4.87 cyclobutoxy- H 4.72 (m, 1 H), 3.68 phenyl}- 3.35 (m, 12H), 3.28 (s, morpholin-4-yl- 3H), 2.48 - 2.36 (m, methanone 2H), 2.13 (m, 2H), 1.81 (m, 1 H), 1.74 - 1.56 (im, 1H). {4-[5-Bromo-4-(2- H NMR (400 MHz, methoxy- DMSO) 6 8.34 (d, J ethylamino)- 8.3 Hz, 1 H), 8.06 (s, pyrimidin-2- 1H), 7.68 (s, 1H), 7.02 ylamino]-3- NH 0 (t, J= 5.5 Hz, 1 H), 6.97 cyclobutoxy- Br (d, J 8.4 Hz, 1H), 124 phenyl}- N 6.86 (s, 1H), 4.90 morpholin-4-yl- N! N 4.67 (m, 1 H), 3.67 methanone H 3.41 (m, 12H), 3.27 (s, 3H), 2.41 (m, 2H), 2.26 - 2.04 (m, 2H), 1.81 (m, 1H), 1.68 (m, 1 H). [4-(5-Chloro-4 methylamino- HNI 0 pyrimidin-2- ci N N 125 ylamino)-3- | NkN N methoxy-phenyl]- H (4-piperidin-4-yl- -o NH piperazin-1-yl) methanone 1 H NMR (400 MHz, {4-[5-Chloro-4- F DMSO) 6 8.20 (d, J (2,2,2-trifluoro- HN hF 8.3 Hz, 1H), 8.10 (s, ethylamino)- CI N F / 1H), 7.92 (s, 1 H), 7.80 126 primidin-2- | 1I (t, J = 6.4 Hz, 1 H), 7.06 ylamino]-3- N N O (s, 1 H), 6.97 (d, J = 8.2 methoxy-phenyl}- H O Hz, 1H), 4.28 - 4.12 morpholin-4-yl- (m, 2H), 3.89 (s, 3H), methanone 3.56 (d, J= 36.1 Hz, 8H). 'H NMR (400 MHz, F DMSO) 6 8.22 (d, J= {4-5-h4loro- HN o 8.3 Hz, 1 H), 8.05 (s, ethylamino)- CI _ F 1H), 7.91 (s, 1H), 7.58 1 yri in -N N 1 H), 7.06 (s, H), 127 pyrmdn2 'q o 6.97 (d, J = 8.3 Hz, ylamino]-3- N 1 H), 6.39 - 6.03 (m, methoxy-phenyl}- 0 1H), 3.86 (d, J= 19.1 metholne - Hz, 3H), 3.87 - 3.69 (m, 2 H), 3.56 (d, J = 35.6 Hz, 8H).

100 Ex. Name Structure 'H NMR Ki H NMR (400 MHz, [4-(5-Bromo-4- 0 0 DMSO) o 8.40 (s, 1 H), [4-Bom- Br 8.23 (d, J = 8.3 Hz, methoxy- N N 1H), 8.13 (s, 1H), 7.08 128 yamin-3- N N J:;)" o (s, 1 H), 7.00 (d, J = 8.3 1 ino)-3poxy- NH Hz, 1H), 6.73 (s, 1H), phenl]-m rphoin .81- 4.61 (in, 1 H), phenyI]-mron- I (s, 3H), 3.55 (d, J = 39.2 Hz, 8H), 1.32 (d, J_= 6.0 Hz, 6H). 'H NMR (400 MHz, [3-Bromo-4-(5- HN ~ 0 DMSO) 6 8.21 (d, J= orom-4-( H08.5 Hz, 1 H), 8.06 (s, mhla io- CI N N H), 7.94 (s, 1H), 7.67 methylamino- N" . HI) 129 pyrimidin-2- ,44 .39 Hz, 1 H), ylamino)-phenyl]- H 7.35 - 7.29 (m, 1 H), morpholin-4-yl- Br 3.67 - 3.38 (m, 8H), methanone 2.87 (d, J = 4.6 Hz, 3H). [4-(5-Bromo-4- 'H NMR (400 MHz, methoxy- DMSO) 6 8.38 (s, 1 H), pyrimidin-2- Br 8.29 (s, 1H), 8.12 (d, ylamino)-3- N N 1H), 7.04 (s, 1H), 6.98 130 methoxy-phenyl]- N' N (d, 1H), 4.13 (s, 1H), [4-(1-hydroxy-1- H 3.98 (s, 3H), 3.88 (s, met -hyetyl)- OH 3H), 1.51-1.32 (m, 2H), piperidin-1-yl]- 1.17 (d, 2H), 1.05 (s, methanone 6H). (4-(5-bromo-4- 0/ 'H NMR (400 MHz, methoxypyrimidin- Br F DMSO) 6 8.39 (s, 1 H), 2-ylamino)-3- N oN F 8.31 (s, 1H), 8.18 (d, 131 methoxyphenyl)(3- N N F 1H), 7.17 (d, 2H), 3.99 (trifluoromethyl)py H (s, 3H), 3.90 (s, 3H), rrolidin-1- 3.77 (dd, 1H), 3.60 (d, yl)methanone 3H).. 'H NMR (400 MHz, 1-(4-(5-bromo-4- 0 DMSO) 6 8.38 (s, 1 H), methoxypyrimidin- Br N N 8.30 (s, 1H), 8.14 (d, 132 2-ylamino)-3- | 1H), 7.08 (s, 1H), 7.01 methoxybenzoyl)p N N (d, 1H), 3.98 (s, 3H), iperidine-4- o 3.89 (s, 3H), 3.15 (s, carbonitrile 2H), 1.90 (s, 2H), 1.80 - 1.67 (m, 2H). (3-methoxy-4-(5- HN 0 1 H NMR (400 MHz, methoxy-4- ,I DMSO) 6 8.56 (d, 1 H), (methylamino)pyri N N 7.58 (s, 1H), 7.32 (s, 133 midin-2- N' N -o 1 H), 7.06 - 6.95 (m, 0.259 ylamino)phenyl) H 3H), 3.92 (d, 3H), 3.75 (morpholino)meth (d, 3H), 3.65 - 3.46 (m, anone 8H), 2.86 (d, 3H).

101 Ex. Name Structure 'H NMR Ki N-(3 aminopropyl)-4-(5- HN 0 chloro-4- cN 134 (methylamino)pyri ClN" N midin-2-ylamino) N N 2 H 2 methoxybenzamid e 1H NMR (400 MHz, DMSO) o 8.46 (d, J = [3-Methoxy-4-(4- HN 8.3, 1H), 7.93 (s, 1H), methylaminoI -- ).6, .0 (d, J7.9(, 135 pyrimidin-2- 0 N N 2H), 3.90 (s, 3H), 3.60 morpholin-4-y- o (s, 4H), 3.52 (s, 4H), methanone 2.91 (d, J = 4.6, 3H), 2.08 (s, 3H). 1H NMR (400 MHz, [3-Methoxy-4-(4- 0 DMSO) 6 8.28 (s, 2H), methoxy-5-prop-1- 8.20 (d, J = 8.2, 2H), 16ynyl-pyrimidin-2- N'NN -) 7.08 (s, 1 H), 7.02 (d, J 0.400 136 o = 8.0, 2H), 3.95 (s, 3H), ylamino)-phenyl]- H 3.89 (s, 3H), 3.61 (s, methanone 4H), 3.52 (s, 4H), 2.05 (s, 3H). [5-Chloro-4-(5- .H NMR (400 MHz, chloro-4- HN 0 0 DMSO) 6 8.11 (s, 1 H), methylamino- N"l 7.99 (s, 1 H), 7.97 (s, 37 pyrimidin-2- N H), 7.38 (m, 1 H), 7.29 137 ylamino)-2- N" N O (s, 1H), 3.82 (s, 3H), methoxy-phenyl]- H 3.60 (s, 4H), 3.52 (t, J morpholin-4-yl- = 4.3, 2H), 3.17 (s, 2H), methanone 2.92 (d, J = 4.6, 3H). /H NMR (400 MHz, {4-[5-Bromo-4-(2- DMSO) 6 8.39 (s, 1 H), methoxy-ethoxy)- 0 0 8.31 (s, 1H), 8.10 (d, J pyrimidin-2- Br = 8.2 Hz, 1H), 7.08 (s, 0.005 139 ylamino]-3- N N)1H), 7.02 (d, J = 8.2 0 methoxy-phenyl}- N Hz, 1H), 4.53 - 4.49 morpholin-4-yl- H (m, 2H), 3.88 (s, 3H), methanone O 3.72 - 3.67 (m, 2H), 3.64 - 3.46 (m, 8H). 5-Chloro-4-(5- NNH o o 'H NMR (400 MHz, chloro-4- DMSO): 6 8.09 (s, 1H), methylamino- CI N N 8.03 (s, 1H), 7.98 (s, 140 pyrimidin-2- I 1 1H), 7.40 (d, J = 5.3 0.011 ylamino)-2- N~io Hz, 1H), 7.25 (s, 1H), 8 methoxy-N,N- N o 3.81 (s, 3H), 2.95 (s, dimethyl- CI 3H), 2.92 (d, J = 4.5 benzamide Hz, 3H), 2.79 (s, 3H).

102 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, 5-Chloro-4-(5- NH O 0 DMSO): 6 8.27 (s, 1 H), chloro-4-C 8.02 (s, 2H), 7.87 (s, methylamino- N NH 2 1H), 7.59 (d, J = 13.4 141 pyrimidin-2- Hz, 2H), 7.47 (d, J = 03 ylamino)-2- N:N 5.4 Hz, 1 H), 3.93 (s, methoxy- H CI 3H), 2.94 (t, J = 2.2 benzamide Hz, 3H). 'H NMR (400 MHz, 5-Chloro-4-(5- DMSO): 6 8.27 (s, 1 H), chloro-4-5 NH o o 8.20 (t, J = 5.5 Hz, 1 H), methylamino- c 11 N 8.02 (d, J = 6.9 Hz, 142 pyrimidin-2- NH 2H), 7.88 (s, 1 H), 7.47 0.011 ylamino)-N-(2- N o (d, J = 5.3 Hz, 1H), 0 hydroxy-ethyl)-2- N 4.81 (s, 1H), 3.94 (s, methoxy- CI OH 3H), 3.51 (t, J = 5.9 benzamide Hz, 2H), 3.40-3.35 (m, 2H), 2.95-2.88 (m, 3H). 'H NMR (400 MHz, 5-Chloro-4-(5- NH o DMSO): 6 8.28 (s, 1 H), chloro-4- 8.20 (s, 1H), 8.02 (d, J methylamino- CI N NH = 6.8 Hz, 2H), 7.87 (s, 143 pyrimidin-2- N 1H), 7.47 (d, J = 5.1 0.015 ylamino)-2- Nlj' N Hz, 1H), 3.94 (s, 3H), 33 methoxy-N-(2- H 3.47-3.43 (m, 5H), methoxy-ethyl)- C 0 N 2.96-2.88 (m, 5H). benzamide 'H NMR (400 MHz, DMSO): 6 8.24 (s, I H), 5-Chloro-4-(5- NH 0 0 8.11 (d, J = 5.5 Hz, chloro-4- cI 1H), 8.03 (d, J = 10.5 methylamino- N NH Hz, 2H), 7.84 (s, 1H), 144 pyrimidin-2- | 7.48 (d, J = 5.5 Hz, 0.011 ylamino)-2- NNN 1H), 3.92 (s, 3H), 2.94 3 methoxy-N- H (d, J = 2.3 Hz, 3H), methyl-benzamide 2.81 (d, J = 4.6 Hz, 3H). 'H NMR (400 MHz, 5-Chloro-4-(5- NNH O O DMSO): 6 8.21 (s, 1 H), chloro-4- 8.02 (d, J = 8.4 Hz, methylamino- CI N NH 3H), 7.75 (s, 1H), 7.45 145 pyrimidin-2- (d, J = 5.3 Hz, 1H), 0.010 ylamino)-N- mK 3.89 (s, 3H), 2.92 (t, J 03 cyclopropyl-2- 4.5 Hz, 3H), 2.82 (tq, methoxy- CI J = 7.4, 3.7 Hz, 1H), benzamide 0.73-0.66 (m, 2H), 0.59-0.53 (m, 2H).

103 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [5-Chloro-4-(5- CDC13): 6 8.47 (s, 1H), chloro-4- 'NH o 7.96 (s, 1H), 7.52 (s, methylamino- NH O O 1H), 7.28 (s, 1H), 5.40 ci (d, J = 5.8 Hz, 1H), pyrimidin-2- N ' 3.99 (s, 1H), 3.87 (s, 0.007 146 ylamino)-2- N N F 3 3.79 (9 3.47 8 methoxy-phenyl]- HI F[(s, 3H), 3.3 (s, 1 H), 34 (4,4-difluoro- H C1 (s, 1 H), 3.38 (s, 1 H), (4,4-idin-1uo - CI3.12 (d, J = 4.9 Hz, piperin-1-yl)- 3H), 2.06 (d, J = 17.3 Hz, 2H), 1.94 (s, 2H). 'H NMR (400 MHz, [5-Chloro-4-(4- CD C13): 6 8.38 (s, 1H), ethylamino-5- F NH o o 8.22 (d, J = 1.1 Hz, trifluoromethyl- 1H), 7.64 (s, 1H), 7.31 147 pyrimidin-2- F N N (s, 1H), 5.19 (s, 1H), 0.003 ylamino)-2- o 3.87 (s, 3H), 3.78 (d, J 4 methoxy-phenyl]- N = 11.5 Hz, 4H), 3.66 morpholin-4-yl- c1 3.56 (m, 4H), 3.32 (s, methanone 2H), 1.30 (t, J = 7.3 Hz, 3H). 'H NMR (400 MHz, CD C13): 6 8.48 (s, IH), 5-Chloro-N- 8.25-8.22 (m, 2H), cyclopropyl-4-(4- F NH o O 7.81 (s, 1H), 7.75 (s, ethylamino-5- F 1H), 5.19 (s, 1H), 3.98 148 trifluoromethyl- F N NH (s, 3H), 3.61 (qd, J = 0.003 pyrimidin-2- F 7.3, 5.2 Hz, 2H), 2.92 5 ylamino)-2- N N (tq, J = 7.1, 3.7 Hz, methoxy- H CI 1H), 1.30 (t, J = 7.3 benzamide Hz, 3H), 0.89-0.83 (m, 2H), 0.60-0.55 (m, 2H). 5-Chloro-4-(4- 'H NMR (400 MHz, ethylamino-5- F NH o o CDC13): 6 8.49 (s, 1H), trifluoromethyl- F 8.24 (s, 2H), 8.12 (s, 149 pyrimidin-2- F N NH 1 H), 7.75 (s, 1H), 5.19 0.009 ylamino)-2- (s, 1 H), 4.00 (s, 3H), 3 methoxy-N-(2- H 3.69-3.55 (m, 6H), methoxy-ethyl)- cI Os 3.41 (s, 3H), 1.30 (t, J benzamide = 7.3 Hz, 3H). 'H NMR (400 MHz, [5-Ohloro-4-(5- N DMSO): 6 8.08 (s, 1 H), chloro-4- NH o 0 8.03 (s, 1H), 7.97 (s, methylamino- c 1H), 7.40 (d, J = 5.3 mhy lN N Hz, 1H), 7.26 (s, 1H), 150 N NH 3.81 (s, 3H), 3.51 (d, J methoxy-phenyl]- =C (s, 2H), 2.92 (d, piperazkin-1-yI- 4.5 Hz, 3H), 2.70 (t, J = 5.2 Hz, 2H), 2.60 (s, 3H).

104 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, DMSO): 6 8.08 (s, 1 H), [5-Chloro-4-(5- 8.03 (s, 1H), 7.97 (s, chloro-4- NH o o 1H), 7.40 (d, J = 5.2 methylamino- Hz, 1H), 7.30 (s, pyrimidin-2- Ci Na 0.5H), 7.23 (s, 0.5H), 0.002 151 ylamino)-2- N N N1 4.43 (s, 1H), 3.80 (s, 8 methoxy-phenyl]- H | 3H), 2.92 (d, J = 4.5 (4-dimethylamino- ci Hz, 3H), 2.80-2.66 (m, piperidin-1-yl)- 1H), 2.35 (d, J = 12.5 methanone Hz, 3H), 2.19 (s, 6H), 1.81 (s, 1H), 1.67 (s, 1H), 1.32 (s, 2H). 'H NMR (400 MHz, DMSO): 6 8.10 (d, J= [5-Chloro-4-(5- 4.1 Hz, 1 H), 8.05-7.97 chloro-4- NH -NO O (m, 2H), 7.40 (d, J = 5.2 Hz, 1 H), 7.26 (s, mehylmi no- C1 N N 1H), 4.98 (s, 1 H), 4.32 52pyrimidno-2- I(s, 1 H), 4.21 (s, 1H), 0.008 152 ylamino)-2- NIN 3.81 (s, 3H), 3.49 (dd, 6 methoxy-phenyl]- H OH J = 9.9, 5.4 Hz, 2H), (3-hydroxy- C1 3.00 (d, J = 11.2 Hz, pyrrolidin-1-yl) 1H), 2.93-2.86 (m, methadone 3H), 1.98-1.80 (m, 1H), 1.78-1.71 (m, 1 H). 'H NMR (400 MHz, 5-Chloro-4-(5- DMSO): 6 8.67 (d, J = chloro-4- NH O 0 6.3 Hz, 1 H), 8.29 (s, chloro-4- C 1H), 8.06 (d, J = 9.2 methya mino- N N NH Hz, 2H), 7.79 (s, 1H), 0.027 153 ylamino)-2- N 7.50 (d, J = 5.3 Hz, nethoxy-N- N 1H), 5.04-4.96 (m, oxetan-3-yl- H C 1 H), 4.86-4.76 (m, benzainide 2H), 4.64-4.57 (m, 2H), 3.97 (s, 3H), 2.97 (d, J = 4.6 Hz, 3H). 'H NMR (400 MHz, 5-Chloro-N- F NH o o CDCl3): 6 8.54 (s, IH), cyclopropyl-2- 8.26 (d, J = 6.2 Hz, methoxy-4-(4- F N NH 2H), 7.82 (d, J = 14.2 154 methylamino-5- F Hz, 2H), 5.32 (s, 1H), 0.005 trifluoromethyl- N N 4.00 (s, 3H), 3.15 (d, J 2 pyrimidin-2- H = 4.7 Hz, 3H), 2.97 ylamino)- C1 2.91 (m, 1H), 0.91 benzamide 0.84 (m, 2H), 0.64 0.58 (m, 2H).

105 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, CDC13): 6 8.54 (s, 1H), 5-Chloro-4-(5- NH 0 0 8.20 (s, 1H), 7.97 (s, 1H), 7.75 (d, J = 8.0 m hyla ino- CI N NH Hz, 1H), 7.62 (s, 1H), pyrimidin-2- 5.40 (d, J = 5.7 Hz, 0.004 155 ylamino)-2- N N H), 4.07-3.94 (m, methoxy-N-(1- H 4H), 3.12 (d, J = 4.9 methyl-piperidin-4- N Hz, 3H), 2.76 (s, 2H), yl)-benzamide 2.31 (s, 3H), 2.32-2.11 (m, 2H), 2.04 (d, J = 12.5 Hz, 2H), 1.68 (s, 2H). 'H NMR (400 MHz, [5-Chloro-4-(5- 1CDC3): 6 8.44 (s, IH), chloro-4- NH 0 7.96 (s, 1H), 7.54-7.48 methylamino- Ci N N (m, 1H), 7.30 (s,1H), 156 pyrimidin-2- 5.37 (s, 1H), 3.87 (s, 0.007 ylamino)-2- N N 3H), 3.62 (t, J = 7.0 4 methoxy-phenyl]- H Hz, 2H), 3.29 (t, J = pyrrolidin-1-yl- CI 6.7 Hz, 2H), 3.12 (d, J methanone = 4.9 Hz, 3H), 1.98 1.81 (m, 4H). N-tert-Butyl-5- NH '-o o 'H NMR (400 MHz, chloro-4-(5-chloro- C CDC13): 6 8.51 (s, 1H), 4-methylamino- CN NH 8.20 (s, 1 H), 7.97 (s, 157 pyrimidin-2- 1H), 7.76 (s, 1H), 7.60 0.028 157pyimiin2- N (s, 1 H), 5.38 (s, 1 H), 2 ylamino)-2- N H\ 3.98 (s, 3H), 3.12 (d, J benzamid H CI = 4.9 Hz, 3H), 1.45 (s, 9H) 5-Chloro-2- F NH o o 'H NMR (400 MHz, methoxy-N,N- F CDC13): 6 8.41 (s, 1H), dimethyl-4-(4- F N N 8.22 (s, 1H), 7.66 (s, 158 m ethylamino- F 1H), 7.29 (s, 1H), 5.30 8 tri m ethy1 N (s, 1 H), 3.87 (s, 3H), y amino)- cI 3.15-3.06 (m, 6H), benzamide 2.93-2.85 (m, 3H). 'H NMR (400 MHz, 5-Chloro-4-(5- NH O O DMSO): 6 8.15-8.02 chloro-4- (m, 2H), 8.01 (s, 1 H), methylamino- CI N N/ 7.42 (s, 1H), 7.26 (d, J 159 pyrimidin-2- = 2.2 Hz, 1H), 3.83 (d, 0.011 ylamino)-2- N5 N J = 4.7 Hz, 3H), 3.59- 51 methoxy-N-(2- H 3.56 (m, 2H), 3.33 (s, methoxy-ethyl)-N- CI O*N 2H), 3.19 (S, 2H), 2.99 methyl-benzamide (s, 3H), 2.94 (s, 2H). 2.86 (s, 2H) 5-Chloro-4-(5- NH 'o o 'H NMR (400 MHz, chloro-4- DMSO): 6 8.30 (s, 1 H), methylamino- C"'N NH 8.16 (t, J = 5.6 Hz, 1H), 0.011 160 pyrimidin-2- OH 8.04 (d, J = 10.5 Hz, 01 ylamino)-N-(2- N 2H), 7.90 (s, 1H), 7.47 hydroxy-2-methyl- cI (d, J = 5.1 Hz, 1H), propyl)-2- 4.68 (s, 1H), 3.96 (s, 106 Ex. Name Structure 'H NMR Ki methoxy- 3H), 3.29 (d, J = 5.6 Hz benzamide 2H), 2.95 (d, J = 3.8 Hz, 3H), 1.13 (s, 6H). 'H NMR (400 MHz, DMSO): 6 8.08 (s, 1 H), [5-Chloro-4-(5- 8.03 (s, 1H), 7.98 (s, chloro-4- NH1H), 7.40 (d, J = 5.0 methylamino- NH O O Hz, 1H), 7.26 (s, 1H), mehymin-ci 4.77 (d, J = 4.0 Hz, 161 pyrimiin-2- N Na o 1H), 4.01 (s, 1H), 3.81 0.003 methoxy-phenyl]- KN NH (s, 3H), 3.72 (d, J = 6 (4-hydroxy- H 7.5 Hz, 1 H), 3.01 (s, piperidin-1 c) 2H), 2.93 (d, J = 4.5 methanone Hz, 3H), 1.77 (s, 1H), 1.67 (s, 1H), 1.36 (d, J = 11.6 Hz, 2H), 1.33 1.20 (m, 1 H). 'H NMR (400 MHz, DMSO): 6 8.14 (d, J= [5-Chloro-4-(5- 3.1 Hz, 1 H), 8.09-7.98 chloro-4- NH o o (m, 2H), 7.43 (s, 1 H), methylamino- c1 7.34 (d, J = 15.4 Hz, pyrimidin-2- C"' ~N N 1H), 4.86 (t, J = 5.6 162 ylamino)-2- " O: 0 Hz, 1H), 4.74 (s, 1H), 0.006 methoxy-p - N N 4.46 (d, J = 13.2 Hz, 9 mehx-phenyl]- H (2-hydroxymethyl- Ci 1H), 4.33 (d, J = 12.8 morpholin-4-yI)- HO Hz, 1H), 4.00-3.90 (m, methanone 1H), 3.85 (s, 3H), 3.39 3.49 (m, 3H), 3.19-3.30 (m, 2H), 2.96-2.83 (m, 3H). 'H NMR (400 MHz, DMSO): 6 8.15-8.03 5-Chloro-4-(5- NH o o (m, 2H), 8.00 (s, 1 H), chloro-4- 7.42 (d, J = 5.3 Hz, methylamino- CI N N/ 1H), 7.28 (d, J = 7.7 163 pyrimidin-2- I Hz, 1H), 4.76 (dt, J = 0.007 ylamino)-N-(2- 16.0, 5.4 Hz, 1H), 3.83 8 hydroxy-ethyl)-2- H (d, J = 5.5 Hz, 3H), methoxy-N- CI OH 3.61 (d, J = 6.2 Hz, methyl-benzamide 1H), 3.42-3.51 (m, 1H), 3.15 (s, 1H), 3.03-2.82 (m, 7H) 5-Chloro-4-(5- 'H NMR (400 MHz, chloro-4- NH o o DMSO): 6 8.27 (s, 1 H), methylamino- 8.06-8.03 (m, 3H), pyrimidin-2- CN NH 7.81 (s, 1H), 7.49 (d, J 164 ylamino)-2- 35.1 Hz, 1 H), 3.96 (s, 0.013 methoxy-N-(1- N Hz, 3H), 2.41-2.29 (m, methyl- H z3H dJ=45 0 cyclobutyl)- CI 2H), 2.06-1.98 (m, benzayide 2H), 1.89-1.79 (m, 2H), 1.50 (s, 3H).

107 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [5-Chloro-4-(5- DMSO): 6 8.12 (s, 1 H), chloro-4- NH O o 8.06 (d, J = 5.2 Hz, methylamino- c .

1H), 8.01 (s, 1H), 7.42 pyrimihin-2- CINN (d, J = 5.4 Hz, 1H), 0.005 165 2lmn)2- 7.31 (s, 1H), 3.93-3.71 0.0 methoxy-phenyl]- N N (m, 4H), 3.79-3.58 (m, [1,4]oxazepan-4- c 5H), 3.59 (s, 2H), 2.95 yl-methanone (d, J = 4.5 Hz, 3H), 1.89 (s, 1H), 1.72 (s, 1 H). 'H NMR (400 MHz, [5-Chloro-4-(5- DMSO): 6 8.16 (s, 1H), chloro-4- 8.03 (d, J = 13.9 Hz, methylamino- NH o o 2H), 7.44 (d, J = 5.1 pyrimidin-2- Ni Hz, 1H), 7.32 (d, J = ylamino)-2- N 12.3 Hz, 1H), 4.40 (d, 0.026 166 metxphenyl]- N O 13.0 Hz, 1(H), 3.84 13 HI ' (s, 3 H), 3.55 (in, 1 H), dimethyl- ' cl 3.21 (m, 1 H), 2.88-2.74 morpholin-4-yl)- (m, 4H), 2.73 (d, J = metphone - 15.3 Hz, 1H), 2.44 (m, methadone 1H), 1.19-1.09 (m, 3H), 1.03 (s, 3H). 'H NMR (400 MHz, 1-[5-Chloro-4-(5- DMSO): 6 8.04 (s, 1 H), chloro-4- NH O o 7.96 (s, 1H), 7.91 (s, methylamino- ci N 1H), 7.31 (t, J = 10.1 167 pyrimidin-2- I Hz, 1H), 7.22 (s, 1H), 0.003 ylamino)-2- NIN 3.88 (m, 1 H), 3.75 (d, J 3 methoxy-benzoyl]- H CN = 9.5 Hz, 3H), 3.22 (m, piperidine-4- 1H), 3.07 (s, 2H), 2.86 carbonitrile (d, J = 4.5 Hz, 3H), 1.86 - 1.61 (m, 5H). 'H NMR (400 MHz, DMSO): 6 8.21 (s, 1 H), 5-Chloro-4-(5- 8.12 (t, J = 5.6 Hz, 1H), chloro-4- NH 7.96 (d, J = 8.5 Hz, methylamino- CI N NH 2H), 7.81 (s, 1H), 7.40 168 pyrimidin-2- y (d, J = 5.2 Hz, 1H), 0.010 ylamino)-N-(2- N N 4.79 (s, 1H), 3.87 (s, 26 hydroxy-propyl)-2- H 3H), 3.75-3.67 (m, methoxy- CI OH 1H), 3.13-3.04 (m, benzamide 1H), 2.87 (d, J = 4.0 Hz, 3H), 1.01 (d, J = 6.2 Hz, 3H). [5-Chloro-4-(5- 'H NMR (400 MHz, chloro-4- INH oDMSO): 6 8.17 (s, 1 H), c thyl no- NH O O8.03 (d, J = 7.5 Hz, pyrimidin-2- 2H), 7.45 (d, J = 5.4 169 yla ino)--H z, 1 H), 7.3 8 (s, 1 H), 0.005 169 ylamino)-2- NAN -. IOH 5.77 (s, 1H), 4.49 (d, J 4 methoxy-phenyl]- H = 6.4 Hz, 1H), 4.21 (t, (3-hydroxy- ci J = 8.5 Hz, 1 H), 4.09 azetidin-1-yl)- (t, J = 8.1 Hz, 1 H), methadone 3.87 (s, 3H), 3.74 (t, J 108 Ex. Name Structure 'H NMR Ki = 6.6 Hz, 2H), 2.98 2.92 (m, 3H). 5-Chloro-4-(5- 'H NMR (400 MHz, chloro-4- NH o o DMSO): 6 8.83 (s, 1 H), methylamino- 8.30 (s, 1H), 8.07 (d, J pyrimidin-2- C NH = 13.6 Hz, 2H), 7.83 170 ylamino)-N-(1- N(s, 1H), 7.51 (d, J = 0.013 cyano- N"'N N ~ . 5.2 Hz, 1 H), 3.94 (s, 9 H N 3H), 2.97 (d, J = 4.5 cyclopropyl)-2- C1 Hz, 3H), 1.61-1.55 (m, methoxy-e 2H), 1.35-1.25 (m, 2H). 1-[5-Chloro-4-(5- 'H NMR (400 MHz, chloro-4- NH o o DMSO): 6 8.05 (d, J = methylamino- clN 6.3 Hz, 2H), 7.93 (d, J pyrimidin-2- N N = 2.0 Hz, 1H), 7.42 (s, 0.004 171 ylamino)-2- NIN 1H), 7.26-7.22 (m, 5 methoxy-benzoyl]- H H), 3.78-3.64 (, pyrrolidine-3- N 4H), 2.88-2.81 (m, 3H), carbonitrile 2.28-2.00 (m, 2H). 'H NMR (400 MHz, [5-Chloro-4-(5- DMSO): 6 8.14 (s, 1H), chloro-4- "NH '-o o 8.02 (t, J = 13.3 Hz, methylamino- 2H), 7.43 (d, J = 5.2 pyrimidin-2- CNN Hz, 1H), 7.30 (s, 1H), 0.033 172 ylamino)-2- NH 4.42 (d, J = 12.5 Hz, methoxy-phenyl]- N N 1H), 3.83 (s, 3H), 3.22 ((3R,5S)-dimethyl- C1 (m, 2H), 2.83-2.53 (m, piperazin-1-yl)- 7H), 1.08 (d, J = 6.2 methanone Hz, 2H), 1.02 (s, 2H), 0.92 (s, 2H). 'H NMR (400 MHz, DMSO): 6 8.63 (s, 1 H), 5-Chloro-2- F NH '-o o 8.25 (s, 1H), 8.06-7.96 methoxy-4-(4- F (m, 2H), 7.78 (s, 1H), methylamino-5- F N NH 7.36 (d, J = 5.2 Hz, metylain-5- F1 1 H), 3.94 (s, 3 H), 3.79 173 trifluoromethyl N NN (m, 1 H) 2.95 H 3.7 0.001 pyrimidin-2- H CI 4.3 Hz, 3H), 2.74 (s, 5 methyl-piperidin-4- N 2H), 2.24 (s, 3H), yl)-benzamide | 2.16-2.09 (m, 2H), 1.84 (d, J = 12.2 Hz, 2H), 1.66-1.54 (m, 2H). 'H NMR (400 MHz, 5-Chloro-2- F NH o o DMSO): 6 8.73 (d, J = methoxy-4-(4- 6.4 Hz, 1 H), 8.64 (s, methylamino-5- F NN NH 1H), 8.26 (s, 1H), 8.06 174 trifluoromethyl- F (s, 1H), 7.78 (s, 1H), 0.004 pyrimidin-2- N -N N 7.37 (d, J = 5.1 Hz, 1 ylamino)-N- H 1H), 5.06-4.96 (m, oxetan-3-yl- CI 1H), 4.79 (t, J = 6.9 benzamide Hz, 2H), 4.60 (t, J = 6.4 Hz, 2H), 3.95 (s, 109 Ex. Name Structure 'H NMR Ki 3H), 2.96 (d, J = 4.3 Hz, 3H). 5-Chloro-N-(2- 'H NMR (400 MHz, hydroxy-2-methyl- F NH '-O o DMSO): 6 8.63 (s, 1 H), propyl)-2- F 8.28 (s, 1H), 8.16 (m, methoxy-4-(4- F N NH 1H), 8.10 (s, 1H), 7.92 0.007 175 methylamino-5- (s, 1H), 7.37 (s, 1H), 9 trifluoromethyl- N N 4.68 (s, 1H), 3.97 (s, pyrimidin-2- CI OH 3H), 3.29 (d, J = 5.8 ylamino)- Hz), 2H), 2.95 (s, 3H), benzamide 1.16 (s, 6H). 'H NMR (400 MHz, [5-Chloro-2- CDC13): 6 8.43 (s, 1H), methoxy-4-(4- F NH o o 8.24 (d, J = 1.1 Hz, methylamino-5- F 1H), 7.69 (s, 1H), 7.30 trifluoromethyl- F (d, J = 11.0 Hz, 1H), 0.004 176 prmdn2NKNNH 5.32 (S, 1 H), 3.89 (S, ylamino)-phenyl]- H 3H), 3.84-3.69 (m, piperazin-1 -yl- H 2H), 3.30 (d, J = 15.4 methann Hz, 3H), 3.14 (d, J = meanone 4.7 Hz, 3H), 2.95 (s, 2H), 2.82 (s, 2H). 1-[5-Chloro-2- oH NMR (400 MHz, methoxy-4-(4- F NH 0 0 DMSO): 6 8.66 (s, 1 H), methylamino-5- F -N N 8.24 (s, 1H), 7.94 (d, J trifluoromethyl- F N= 6.7 Hz,1 H), 7.36 (s, 0.002 177 pyrimidin-2- No<N 1IH), 7.31 (s, 1IH), 9 ylamino)-benzoyl]- H CI 3.88-3.75 (m, 4H), pyrrolidine-3- N~ 3.63-3.49 (m, 4H), carbonitrile 2.94 (t, J = 3.9 Hz, 3H), cabntie2.37-2.10 (m, 2H). 'H NMR (400 MHz, DMSO): 6 8.38 (dd, J 1-[2-Fluoro-5- = 12.4, 3.9 Hz, 1H), methoxy-4-(4- F NH F 0 8.29 (s, 1H), 8.17 (s, methy - - F 1H), 7.41 (s, 1H), 7.08 methylamino-5 F N N (d, J = 6.2 Hz, 1H), 0.001 178 tKrilormet- N 3.93 (d, J = 1.6 Hz, 8 ylami-bnzoyl]- H O 3H), 3.67 (d, J = 23.8 pyrrolidine-3- N Hz, 2H), 3.58 (t, J = carbonitrile 8.9 Hz, 2H), 3.50-3.43 (m, 1 H), 2.98 (dd, J = 4.3, 2.3 Hz, 3H), 2.39 2.13 (m, 2H). 1 H NMR (400 MHz, [5-Chloro-2- DC13): 6 8.39 (s, IH), ethoxy-4-(4- F NH O O 8.22 (d, J = 1.1 Hz, methylamino-5- F 1H), 7.65 (s, 1H), 7.32 trifluoromethyl- F N N (s, 1H), 5.29 (s, 1H), O.024 179 pyrimidin-2- N O 4.10 (s, 2H), 3.76 (s, 72 ylamino)-phenyl]- H 4H), 3.67 (s, 1 H), 3.61 morpholin-4-yI- cl (s, 1H), 3.37 (s, 1H), methanone 3.29 (s, 1H), 3.11 (d, J = 4.7 Hz, 3H), 1.43 (t, J = 7.0 Hz, 3H).

110 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, 2-Fluoro-5- F NH F O DMSO): 6 8.37 (d, J= methoxy-N- 13.4 Hz, 1H), 8.30 (s, methyl-4-(4- F pN NH 1H), 8.18 (s, 1H), 8.07 180 methylamino-5- F (s, 1 H), 7.42 (d, J = 0.004 trifluoromethyl- N N 5.1 Hz, 1H), 7.30 (d, J 7 pyrimidin-2- H = 6.7 Hz, 1H), 3.94 (s, ylamino)- -O 3H), 2.98 (d, J = 4.2 benzamide Hz, 3H), 2.82 (d, J = 4.5 Hz, 3H). 5-Chloro-N-(2- 'H NMR (400 MHz, hydroxy-2-methyl- F NO O CDCl3): 6 8.44 (s, 1H), m toy-- F 8.22 (s, 1H), 7.68 (s, methyl-4-(4- F N N 1H), 7.32 (s, 1H), 5.31 0.006 181 methylamino-5- N (s, 1H), 4.08 (s, 1H)' 3 trifluoromethyl- 3.95 (s, 3H), 3.58 (s, pyrimidin-2- CI HO 2H), 3.13 (d, J = 4.6 p r d -- Hz, 3H), 3.01 (s, 3H), benzaminde 1.32 (s, 6H). 1H NMR (400 MHz, (4-(5-cyclopropyl- 0l 0DMSO) 6 8.60 (d, 1 H), 4- 7.74 (s, 1H), 7.41 (s, mN N H), 7.03 (s, 1H), 7.00 182 2- yino)-3 - N (d, 1 H), 6.50 (d, J = 0.089 182 2-ylamino)-3- ~ N N 4.7, 1H), 3.91 (s, 3H), 5 methoxyphenyl)(m H 3.56 (m, 8H), 2.87 (d, orpholino)methan 3H), 2.35 - 2.27 (m, one 2H), 2.02 - 1.91 (m, 3H), 1.24 (s, 2H) 1H NMR (400 MHz, 1-{2-[2-Methoxy-4- 0 NH O DMSO) 6 9.21 - 9.05 (morpholine-4- (m, 1H), 8.71 (s, 1H), carbonyl)- N N 8.35 (d, J = 8.2, 1H), 0.068 183 phenylamino]-4- O 8.25 (s, 1H), 7.09 (s, 2 methylamino- H 1H), 7.03 (d, J = 8.3, pyrimidin-5-yl}- 1-0 1H), 3.90 (s, 3H), 3.56 ethanone (s, 8H), 2.99 (d, J = 4.8, 3H), 2.45 (s, 3H). /1 1 H NMR (400 MHz, {4-[5-Chloro-4-(2- DMSO) 6 8.32 (m, 2H), methoxy-ethoxy)- O 0 8.11 (d, J= 8.2 Hz, pyrimidin-2- c1 1H), 7.08 (s, 1H), 7.02 0.018 184 ylamino]-3- N N (d, J= 8.2 Hz, 1H), 1 methoxy-phenyl}- N O 4.60 - 4.41 (m, 2H), morpholin-4-yl- 3.88 (s, 3H), 3.74 methanone O 3.65 (m, 2H), 3.56 (m, 8H).

111 Ex. Name Structure 'H NMR Ki {4-[5-Bromo-4-(2- o 1 H NMR (400 MHz, ethyla o)- NH F O DMSO) 6 8.27 (d, J= etylmin)- B H F 012.3 Hz, IH), 8.11 (s, 185 ylami]-2-fluoro- Br N N 1 H), 7.78 (s, 1H), 7.12 0.006 5-methoxy- I I (t, J= 5.5 Hz, 1H), 7.01 9 phenylt- N N (t, J= 10.3 Hz, 1H), phnyl} - H 3.89 (s, 3H), 3.57 (m, morpholin-4-yl- 0 12H), 3.27 (s, 3H). methanone {4-[5-Bromo-4-(2- 1 H NMR (400 MHz, {4om(- DMSO) 6 8.37 (d, J= ethylamino)- NH 0 8.3 Hz, 1 H), 8.06 (s, Br 1H), 7.64 (s, 1H), 186 yamin]-3- ' 7N - 7.00 (i, 2H), 0.013 isopropoxy- II 696(d, J =8.3 Hz, 5 phenyl- H 1H), 4.72 (dt, J= 12.0, morphol in-4-yl- 6.0 Hz, 1H), 3.71 methanone 3.40 (m, 12H), 3.28 (s, 3H), 1.33 (d, 6H). 1 H NMR (400 MHz, DMSO) 6 8.34 (s, 1 H), {4-[5-Chloro-4-(2- 8.24 (s, 1H), 8.13 (d, J methoxy-ethoxy)- 0 0 = 8.2 Hz, 1H), 7.01 (d, pyrimidin-2- J = 8.3 Hz, 1 H), 6.88 187 ylamino]-3- N N (s, 1 H), 4.93 - 4.73 (m, 0.014 cyclobutoxy- N N O 1 H), 4.59 - 4.47 (m, 3 phenyl}- H 2H), 3.78 - 3.66 (m, morpholin-4-yl- 0 2H), 3.55 (m, 8H), 2.43 methanone (m, 2H), 2.25 - 2.00 (m, 2H), 1.80 (m, 1H), 1.74 - 1.47 (m, 1 H). 1 H NMR (400 MHz, [4-(5-Chloro-4- NH O DMSO) 6 8.43 (d, J= methylamino- 8.3 Hz, 1 H), 7.95 (s, pyrimidin-2- C NN% 1H), 7.59 (s, 1H), 7.33 ylamino)-3- (d, J = 4.3 Hz, .99 0 006 188 cyclopentyloxy- N O N O 7.03 (s, 1H), 6.99 (d, J phenyl]-(2-oxa-6- 0 = 8.3 Hz, 1H), 4.96 (m, aza- 1H), 3.56 (dim, 8H), spiro[3.3]hept-6- 2.92 (d, J= 4.5 Hz, yl)-methanone 3H), 2.00 - 1.85 (m, 2H), 1.73 (m, 6H). 'H NMR (400 MHz, NH 0 DMSO) 6 8.43 (d, J= [4-(5-Chloro-4- 8.3 Hz, 1 H), 7.95 (s, methylamino- Cl N N 1H), 7.59 (s, 1H), 7.33 pyrimidin-2- N<SNo (d, J= 4.3 Hz, 1H), 0.012 189 ylamino)-3- N N 7.03 (s, 1H), 6.99 (d, J 603 cyclopentyloxy- 0 = 8.3 Hz, 1H), 4.96 phenyl]-morpholin- (sm, 1 H), 3.56 (dm, 4-yl-methanone 8H), 2.92 (d, J = 4.5 Hz, 3H), 2.02 - 1.85 (m, 2H), 1.73 (tm, 6H).

112 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [4-(5-Chloro-4- DMSO) o 8.45 (d, J= methylamino- NH 0 8.9 Hz, 1 H), 7.98 (s, pyrimidin-2- ci N N 1H), 7.71 (s, 1H), 7.34 190ylamino)-3- I (d, J = 4.4 Hz, 1 H), 0.006 methoxy-phenyl]- NI N 0 7.23 (d, 2H), 4.69 (s, 3 (2-oxa-6-aza- H 4H), 4.53 (s, 2H), 4.19 spiro[3.3]hept-6- (s, 2H), 3.92 (s, 3H), yl)-methanone 2.92 (d, J = 4.5 Hz, 3H). 2-(2-methoxy-4- 1H NMR (400 MHz, (2,2,6,6- DMSO) 6 8.37 (s, 1 H), tetrafluoromorphol NH 8.33 (d, J = 8.1 Hz, ine-4- N~F .(dJ=81z 191 arbonyl)phenyla N N F 1H), 7.13 - 7.07 (m, 0.020 mino)-4- N 'N O 2H), 4.32 (t, J = 8.6 Hz, 8 (methylamino)pyri H F F H), 3.91 (s, 3H), 2.90 midine-5 carbonitrile 1H NMR (400 MHz, 2-(4-(4,4- DMSO) 6 8.36 (s, 1 H), difluoropiperidine- NH 8.35 (s, 1H), 8.18 (d, J 1-aronl)2- N4 ,k = 8.2 Hz, 1 H), 7.79 (d, methoxyphenylam N I N J = 4.3 Hz, 1 H), 7.12 0.014 192 io--Ie ) J ;e. F (s, 1 H), 7.05 (d, J = 9.19 (methylamino)pyri H F Hz, 1H), 3.88 (s, 3H), midine-5- 3.59 (br s, 4H), 2.88 (d, carbonitrile J = 4.4 Hz, 3H), 2.12 1.96 (m, 4H) 1 H NMR (400 MHz, DMSO) 6 8.19 (s, 1 H), [4-(5-Chloro-4- HN 0 8.05 (d, J = 8.4 Hz, methylamino- 1H), 7.91 (s, 1H), mehyamin- ci N N 7.26 - 7.18 (m, 2H), 193 ylamino)-3- C [l)10 7.07 - 7.03 (m, 1 H), 0.023 N N 13.66 - 3.41 (m, 8H), 9 cyclopropyl- H 2.88 (d, J = 4.6 Hz, phenyl]-morpholin- 3H), 2.06 - 1.97 (m, 4-yl-methanone 1H), 0.99 - 0.91 (m, 2H), 0.63 - 0.57 (m, 2H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- NH o DMSO): 6 8.69 (d, J = pyrimidin-2- N, 6.6 Hz, 1 H), 8.36 (s, ylamino)-N-(3,3- N NH 1H), 8.33 (s, 1H), 8.29 194 difluoro- (d, J = 8.3 Hz, 1H), 0.006 cyclobutyl)-3- N ' N 7.80 (m, 1 H), 7.41 (m, 5 methoxy- H 2H), 4.37-4.19 (m, 1H), benzamide F F 3.92 (s, 3H),3.06-2.84 (m, 5H), 2.84-2.63 (m, 2H).

113 Ex. Name Structure 'H NMR Ki 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- DMSO): 6 8.46 (t, J = pyrimidin-2- 5.6 Hz, 1 H), 8.35 (s, ylamino)-N- NH 0 1H), 8.33-8.17 (m, 2H), cyclopropylmethyl- N NH 7.78 (s, 1H), 7.51 (d, J 3-methoxy- =I7.1 Hz, 2H), 3.92 (s, 0.004 195 benzamide N N 3H), 3.15 (app t, J = 2 H 6.2 Hz, 2H), 2.90 (d, J = 2.0 Hz, 3H), 1.21 0.90, m, 1H), 0.64-0.35 (m, 2H), 0.30-0.12 (m,2H). 2-[4-((S)-3-Fluoro- 'H NMR (400 MHz, pyrrolidine-1- N DMSO): 6 8.35 (s, 1 H), carbonyl)-2- N 8.31 (s, 1H), 8.21 (d, J methoxy- N N.' N = 8.2 Hz), 1H), 7.75 (m, 0.006 196 phenylamino]-4- 1 H), 7.22-7.14 (m, 2H), 0 methylamino- N N 3.89 (s, 3H), 3.84-3.54 pyrimidine-5- H O (m, 5H), 2.89 (d, J = carbonitrile 4.5 Hz, 3H), 2.27-2.00 (m, 2H). 4-(5-Cyano-4- NH O 'H NMR (400 MHz, methylamino- N DMSO): 6 8.43-8.27 pyrimidin-2- N NH (m, 3H), 8.24 (d, J = 197 ylamino)-3- | | 8.4 Hz, 1 H), 7.77 (m, 0.006 methoxy-N- NN N 1H), 7.51-7.45 (m, 2H), 6 methyl-benzamide H 3.91 (s, 3H), 2.89 (d, J -0 = 4.5 Hz, 3H), 2.78 (d, J = 4.5 Hz, 3H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- NH O DMSO): 6 8.33 (s, I H), pyrimidin-2- N 8.31 (s, 1H), 8.15 (d, J ylamino)-3- N N/-' = 8.2 Hz, 1H), 7.73 (m, 198 methoxy-N,N- 1H), 7.07 (d, J = 1.4 0.012 dimethyl- N N Hz, 1H), 7.00 (dd, J = 40 benzamide H 8.2, 1.5 Hz, 1H), 3.87 (s, 3H), 2.97 (s, 6H), 2.85 (d, J = 3.6 Hz, 3H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- NH 0 DMSO): 6 8.32 (s, 1 H), pyrimidin-2- N 8.30 (s, 1H), 8.13 (d, J ylamino)-N,N- N N = 8.2 Hz, 1H), 7.71 (m, 199 diethyl-3-methoxy- 1H), 7.00 (d, J = 1.3 0.006 benzamide N N Hz, 1H), 6.93 (dd, J= 8 H 8.2, 1.5 Hz, 1H), 3.87 (s, 3H), 3.42-3.30 (m, 4H), 2.87 (s, 3H), 1.11 (t, J = 6.8 Hz, 6H). 4-(5-Cyano-4- NH O 'H NMR (400 MHz, methylamino- N DMSO): 6 8.35 (s, 1 H), pyrimidin-2- N NH 8.30 (s, 1H), 8.25 (d, J 0.004 200 ylamino)-N- | = 8.6 Hz, 1H), 8.09 (d, 4 isopropyl-3- N N NJ = 7.7 Hz, 1 H), 7.76 methoxy- H (m, 1H), 7.51 (s, 1H), benzamide /O 7.49 (s, 1H), 4.10 (dq, J 114 Ex. Name Structure 'H NMR Ki = 13.5, 6.7 Hz, 1H), 3.92 (s, 3H), 2.90 (d, J = 4.1 Hz, 3H), 1.17 (d, J = 6.6 Hz, 6H). 2-[2-Methoxy-4- 'H NMR (400 MHz, (pyrrolidine-1- DMSO): 6 8.34 (s, 1 H), carbonyl)- NH O 8.30 (s, 1H), 8.18 (d, J phenylamino]-4- N = 8.2 Hz, 1H), 7.74 (m, methylamino- N 1H), 7.17 (d, J = 1.3 0.014 201 pyrimidine-5- NHz, 1 H), 7.13 (dd,J= 01 carbonitrile 8.3, 1.5 Hz, 1H), 3.88 0 (s, 3H), 3.46 (t, J = 6.6 Hz, 4H), 2.89 (d, J = 3.3 Hz, 3H), 1.92-1.78 (m, 4H). 2-[4-(3-Fluoro- NNH O 'H NMR (400 MHz, azetidine-1- N DMSO): 6 8.36 (s, 1H), carbonyl)-2- N NH 8.31 (s, 1H), 8.27 (d, J methoxy- = 8.5 Hz, 1H), 7.79 (m' 0,013 202 phenylamino]-4- N :'KN 1H), 7.27 (dd, J = 4.2 85 methylamino- H 2.6 Hz, 2H), 4.75-4.00 pyrimidine-5- 0 (m, 5H), 3.91 (s, 3H), carbonitrile F 3.29 (m, 2H), 2.90 (d, J = 2.0 Hz, 3H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- NH O DMSO): 6 8.40-8.33 pyrimidin-2- N (m, 2H), 8.30 (s, 1H), ylamino)-N-ethyl- N NH 8.20 (d, J = 8.2 Hz, 203 3-methoxy- N 1H), 7.78 (m, 1H), 7.50 0.009 benzamide N (s, 1 H), 7.48 (s, 1 H), H 3.89 (s, 3H), 3.30 (m, 2H), 2.93 (s, 3H), 1.13 (t, J = 7.2 Hz, 3H). 2-[2-Methoxy-4- 'H NMR (400 MHz, (piperidine-1- DMSO): 6 8.32 (s, 1 H), carbonyl)- NH O 8.31 (s, 1H), 8.15 (d, J phenylamino]-4- N.> = 8.2 Hz, 1 H), 7.72 (m, 204 methylamino- N N 1H), 7.03 (d, J = 1.4 0.003 pyrimidine-5- N N Hz, 1H), 6.96 (dd, J 3 carbonitrile H 8.2, 1.4 Hz, 1H), 3.87 11 (s, 3H), 3.45 (br s, 4H), 2.88 (d, J = 4.5 Hz, 3H), 1.68-1.45 (m, 6H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- DMSO): 6 8.76 (t, J = pyrimidin-2- NH O 5.8 Hz, 1 H), 8.36 (s, ylamino)-N-(2,2- N 1 H), 8.33 (s, 1 H), 8.29 difluoro-ethyl)-3- N NH (d, J = 8.8 Hz, 1H), 205 methoxy- I N F 7.80 (m, 1 H), 7.55 (s, 1 benzamide H 1H), 7.53 (d, J = 1.6 O F Hz, 1H), 6.25-5.97 (m, 1H), 3.92 (s, 3H), 3.82 3.56 (m, 2H), 2.90 (s, 3H).

115 Ex. Name Structure 'H NMR Ki N-tert-Butyl-4-(5- N-NH O 'H NMR (400 MHz, cyano-4- N DMSO): 6 8.35 (s, 1H), methylamino- N NH 8.29 (s, 1H), 8.22 (d, J 206 pyrimidin-2-= 8.3 Hz, 1H), 7.78 (m, 0.004 ylamino)-3- N1N 1H), 7.63 (s, 1H), 7.51- 6 methoxy- H 7.44 (m, 2H), 3.93 (s, benzamide O 3H), 2.90 (s, 3H), 1.39 (s, 9H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- N-NH O DMSO): 6 8.32 (s, 1 H), pyrimidin-2- N 8.31 (s, 1H), 8.12 (d, J ylamino)-N-ethyl- - N 0 N = 8.2 Hz, 1H), 7.71 (m, 207 N-isopropyl-3- 1H), 6.97 (d, J = 1.2 0.005 methoxy- N N Hz, 1H), 6.90 (d, J= 4 benzamide H 8.2 Hz, 1H), 4.10-3.88 O0 (m, 3H), 3.87 (s, 3H), 2.87 (d, J = 4.5 Hz, 3H), 1.15 (m 9H). 2-[4-(3,3-Difluoro- 'H NMR (400 MHz, pyrrolidine-1- N DMSO): 6 8.35 (s, 1 H), carbonyl)-2- N 8.31 (s, 1H), 8.24 (d, J methoxy- N N = 8.2 Hz, 1H), 7.77 (m, 208 phenylamino]-4- 1 H), 7.23-7.14 (m, 2H), 0.008 methylamino- N N F 3.91 (s, 3H), 4.00-3.84 1 pyrimidine-5- H O F (m, 2H), 3.74 (t, J = 7.1 carbonitrile Hz, 2H), 89 (d, J = 4.2 Hz, 3H), 2.54-2.37 (m, 2H). 2-[4-(3,3-Difluoro- N' H NMR (400 MHz, azetidine-1- NH 0 DMSO): 6 8.37 (s, 1H), carbonyl)-2- N N 8.33 (s, 1H), 8.30 (d, J 209 methoxy- F = 8.3 Hz, 1H), 7.80 (m, 0.023 phenylamino]-4- N N F 1H), 7.38-7.27 (m, 2H), 82 methylamino- H o 4.90-4.40 (m, 4H), 3.92 pyrimidine-5- (s, 3H), 2.90 (d, J = 4.5 carbonitrile Hz, 3H). 2-[4-((R)-3-Fluoro- 'H NMR (400 MHz, pyrrolidine-1- NH 0 DMSO): 6 8.35 (s, 1H), carbonyl)-2- N 8.31 (s, 1H), 8.21 (d, J methoxy- N N = 8.2 Hz, 1H), 7.75 (m, 210 phenylamino]-4- N H), 7.23-7.12 (m, 2H 0009 methylamino- H3.89 (s, 3H), 3.85-3.49 pyrimidine-5- 0 F (m, 5H), 2.89 (d, J = carbonitrile 4.5 Hz, 3H), 2.22-1.95 (m, 2H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- DMSO): 6 8.33 (s, 1H), pyrimidin-2- NH O 8.31 (s, 1H), 8.14 (d, J ylamino)-N-ethyl- N = 8.2 Hz, 1H), 7.72 (m, 3-methoxy-N- N N N H), 7.03 (s, 1H), 6.97 211 methyl-benzamide N N(d, J = 8.2 Hz, 1H), 0017 N 3.87 (s, 3H),3.50-3.20 0 (m, 2H), 2.93 (s, 3H), 2.88 (d, J = 4.4 Hz, 3H), 1.11 (t, J = 6.9 Hz, 3H).

116 Ex. Name Structure 'H NMR Ki 2-[4-(Azetidine-l- 'H NMR (400 MHz, carbonyl)-2- N NH 0 DMSO): 6 8.35 (s, 1H), methoxy- N 8.30 (s, 1H), 8.23 (d, J phenylamino]-4- N No = 8.3 Hz, 1H), 7.77 (m, 212 methylamino- N 1H), 7.26-7.20 (m, 2H), 02 pyrimidine-5- H 4.34 (br s, 2H), 4.04 (br carbonitrile H 0 s, 2H), 3.90 (s, 3H), 2.89 (d, J = 4.5 Hz, 3H), 2.36-2.18 (m, 2H). 4-(5-Cyano-4- 'H NMR (400 MHz, methylamino- DMSO): 6 8.32 (d, J = pyrimidin-2- NNH 0 4.6 Hz, 1 H), 8.31 (s, ylamino)-N- N 1H), 8.14 (d, J = 8.2 isopropyl-3- N N - Hz, 1H), 7.72 (m, 1H), 213 methoxy-N- 7.02 (s, 1H), 6.95 (d, J 0.006 methyl-benzamide N N = 8.1 Hz, 1H), 4.10- 8 H 3.88 (m, 1 H), 3.87 (s, O1 3H), 2.88 (d, J = 4.5 Hz, 3H), 2.79 (s, 3H),1.13 (d, J = 6.7 Hz, 6H). 'H NMR (400 MHz, 0 DMSO) 6 8.29 (d, J= {4-[5-Chloro-4- 8.3 Hz, 1 H), 8.00 (s, (tetrahydro-furan- NH 0 1H), 7.76 (s, 1H), 7.16 3-ylamino)- (d, J= 6.3 Hz, 1H), 214 pyrimidin-2- CI N N 7.03 (dd, J= 15.4, 4.8 0.018 ylamino]-3- Hz, 2H), 3.96 - 3.78 4 methoxy-phenyl}- N N (m, 5H), 3.73 (d, J = morpholin-4-yl- H O 6.2 Hz, 1H), 3.58 (t, J= methanone 21.4 Hz, 8H), 2.20 (dd, J= 12.8, 6.7 Hz, 2H), 2.11 - 1.90 (m, 2H). [3-Isopropoxy-4- 1 H NMR (400 MHz, (4-methylamino-5- DMSO) 6 8.40 (d, J trifluoromethyl- F NNH 0 8.3 Hz, 1H), 8.19 (s, pyrimidin-2- F 1H), 7.95 (s, 1H), 7.26 ylamino)-phenyl]- F N N (d, J = 4.2 Hz, 1 H), morpholin-4-yl- N N 0 7.08 (s, 1H), 7.00 (d, J 0.009 methanone H = 8.3 Hz, 1H), 4.73 (dt, 4 0 J = 12.1, 6.1 Hz, 1 H), 3.55 (d, J= 38.1 Hz, 8H), 2.94 (d, J = 4.3 Hz, 3H), 1.33 (d, J= 6.0 Hz, 6H). [3-Ethoxy-4-(4- 1 H NMR (400 MHz, methylamino-5- DMSO) 6 8.35 (s, 1 H), trifluoromethyl- F NH 0 8.19 (s, 1H), 8.02 (s, pyrimidin-2- F N-N -N 1H), 7.24 (s, 1H), 7.06 ylamino)-phenyl]- F I (s, 1 H), 7.01 (d, J = 8.2 0.004 216 morpholin-4-yl- N N O Hz, 1H), 4.16 (q, J= 2 methanone H 7.0 Hz, 1 H), 3.55 (d, J = 38.1 Hz, 8H), 2.93 (d, J = 4.3 Hz, 2H), 1.39 (t, J_= 6.9 Hz, 3H).

117 Ex. Name Structure 'H NMR Ki [4-(5-Chloro-4- 1 H NMR (400 MHz, methylamino- NH 0 DMSO) o 8.39 (d, J pyrimidin-2- cl 8.3 Hz, 1H), 7.94 (s, ylamino)-3- N N 1H), 7.56 (s, 1H), 7.32 217 cyclopropoxy N (s, 2H), 7.03 (d, J = 8.3 0.002 phenyl]-morpholin- H Hz, 1H), 3.98 (s, 1H), 0 4-yl-methanone O 3.57 (d, J= 33.3 Hz, 8H), 2.91 (d, J = 4.5 Hz, 3H), 0.88 - 0.69 m, 4H). [4-(5-Bromo-4- NH O H NMR (400 MHz, methoxy- B_ DMSO) 6 8.37 (s, 1 H), pyrimidin-2- B N N 8.22 (s, 1H), 8.13 (d, J ylamino)-3- N0 = 8.2 Hz, 1H), 7.35 (s, 0.002 218 cyclopropoxy- N "N 0 1H), 7.05 (d, J = 8.3 0 phenyl]-morpholin- H 0 Hz, 1H), 3.98 (s, 3H), 4-yl-methanone 3.57 (d, J= 36.5 Hz, 'V 8H), 0.87 - 0.70 (m, 4H). {4-[5-Chloro-4-(2- 4H NMR (400 MHz, methanesulfonyl- DMSO) 6 8.30 (d, J ethylamino)- S 8.3 Hz, 1 H), 8.02 (s, pyrimidin-2- HN 0 0 1H), 7.83 (s, 1H), 7.47 ylamino]-3- cN N (s, 1 H), 7.06 (s, 1 H), 0.026 219 methoxy-phenyl}- N N 7.01 (d, J= 8.2 Hz, 0 morpholin-4-yl- NC ] N'NN O 1H), 3.90 (s, 3H), 3.82 methanone H (d, J = 6.8 Hz, 2H), lo 3.56 (d, J = 34.4 Hz, 8H), 3.44 (t, J= 7.1 Hz, 2H), 3.03 (s, 3H). 2-[4-(5-Bromo-4- 1 H NMR (400 MHz, methylamino- DMSO) 6 8.14 (s, 1 H), pyrimidin-2- NH 8.00 (s, 1H), 7.56 (s, ylamino)-2,5- Br , N NJ 1H), 7.11 (d, J= 4.5 220 dimethoxy- Hz, 1H), 6.79 (s, 1H), 0.003 phenyl]-1- N" N 3.79 (s, 3H), 3.73 (s, 4 morpholin-4-yl- H 0O 3H), 3.56 (s, 2H), 3.49 ethanone (dd, J = 24.0, 5.0 Hz, 8H), 2.94 (d, J = 4.5 Hz, 3H). 2-[4-(5-Chloro-4- 1 H NMR (400 MHz, methylamino- NH N DMSO) 6 8.15 (s, 1 H), pyrimidin-2- NH O 7.93 (s, 1H), 7.55 (s, ylamino)-2,5- Ci N N 1H), 7.29 (d, J= 4.4 221 dimethoxy- 0 Hz, 1H), 6.79 (s, 1H), 0.008 phenyl]-1- N"'N 3.79 (s, 3H), 3.73 (s, 7 morpholin-4-y- H O 3H), 3.56 (s, 2H), 3.49 ethanone (dd, J = 24.0, 5.2 Hz, 8H), 2.94 (d, J = 4.6 Hz, 3H). 2-[4-(5-Chloro-4- NH O ' H NMR (400 MHz, methylamino- CN DMSO) 6 8.18 (d, J 222 pyrimidin-2- N 8.2 Hz, 1 H), 7.90 (s, 0.009 ylamino)-3 N N 1H), 7.54 (s, 1H), 7.22 0 methoxy-phenyl]- H (s, 1H), 6.88 (s, 1H), 1-morpholin-4-yl- 0 N 6.77 (d, J= 8.5 Hz, 118 Ex. Name Structure 'H NMR Ki ethanone 1H), 3.83 (s, 3H), 3.66 (s, 2 H), 3.51 (d, J = 19.1 Hz, 8H), 2.88 (d, J = 4.5 Hz, 3H). 2-[3-Methoxy-4-(4- 1 H NMR (400 MHz, methylamino-5- DMSO) o 8.13 (s, 1 H), trifluoromethyl- F NH O 8.05 (d, J= 8.2 Hz, pyrimidin-2- FC 1H), 7.99 (s, 1 H), 7.12 ylamino)-phenyl]- F I N (s, 1H), 6.90 (s, 1 H), 223 1-morpholin-4-yl- N 0 6.79 (d, J= 8.7 Hz, 0.005 ethanone H 1H), 6.65 (s, 1H), 3.82 (s, 3H), 3.68 (s, 2H), 3.51 (d, J= 17.5 Hz, 8H), 2.88 (d, J = 4.2 Hz, 3H). 2-[4-(5-Chloro-4- 1 H NMR (400 MHz, methoxy- DMSO) o 8.29 (s, 1 H), pyrimidin-2- Cl NN N 8.18 (s, 1H), 7.81 (s, 224 ylamino)-2,5- 1H), 6.83 (s, 1H), 4.01 0.021 dimethoxy- N N (s, 3H), 3.78 (s, 3H), 13 phenyl]-1- H 3.73 (s, 3H), 3.58 (s, morpholin-4-yl- 2H), 3.49 (d, J = 28.3 ethanone Hz, 8H). 2-[4-(5-Chloro-4- 1 H NMR (400 MHz, methoxy- <No DMSO) o 8.22 (d, J pyrimidin-2- 16.9 Hz, 2H), 7.88 (d, J ylamino)-3- N = 8.2 Hz, 1H), 6.91 (s, 225 methoxy-phenyl]- NKN 0 1H), 6.80 (d, J= 8.2 011 1-morpholin-4-yl- H Hz, 1H), 3.95 (s, 3H), ethanone 3.81 (s, 3H), 3.69 (s, 2H), 3.51 (d, J= 17.2 Hz, 8H). 2-[4-(5-Bromo-4- 1 H NMR (400 MHz, methoxy- N 0 0 DMSO) 6 8.31 (s, 1 H), pyrimidin-2- B N 8.22 (s, 1H), 7.87 (d, J ylamino)-3- N = .1 Hz, 1H), 6.91 (s, 226 methoxy-phenyl]- N N O 1H), 6.80 (d, J= 7.9 0.005 1-morpholin-4-yl- H Hz, 1H), 3.94 (s, 3H), 6 ethanone ON 3.81 (s, 3H), 3.69 (s, 2H), 3.50 (t, J= 12.7 Hz, 8H). 2-[2,5-Dimethoxy- 'H NMR (400 MHz, 4-(4-methylamino- F NH 0 DMSO) o 8.16 (s, 1 H), 5-trifluoromethyl- F N), NJ 8.04 (s, 1H), 7.94 (s, 227 pyrimidin-2- F A N 1H), 7.20 (s, 1H), 6.82 0.003 ylamino)-phenyl]- N (s, 1H), 3.79 (s, 3H), 7 1-morpholin-4-yl- H O 3.73 (s, 3H), 3.58 (s, ethanone 2H), 3.49 (d, J = 24.9 Hz, 8H), 2.96 (s, 3H). N-(3-Amino- NH o o propyl)-5-chloro-4 (5-chloro-4- Ci N NH 0.003 228 methylamino- 8 pyrimidin-2- N ylamino)-2- ci methoxy-

NH

2 119 Ex. Name Structure 'H NMR Ki benzamide {4-[5-Bromo-4-(2 methoxy- NH ethylamino) 229 pyrimidin-2- Br N N004 ylamino]-3- 1 methoxy-phenyl}- NIN morpholin-4-yl- H methanone {4-[5-Chloro-4-(2 methoxy- NH propylamino) 230 pyrimidin-2- Cl-N N 0.009 ylamino]-3- 6 methoxy-phenyl}- NI N:) morpholin-4-yl- H O methanone 4-(5-chloro-4- NH 0 (methylamino)pyri c 231 midin-2-ylamino)- N N N,N,3 trimethylbenzamid N N e H (4-(5-chloro-4 (methylamino)pyri NH 0 midin-2-ylamino)- cN 232 3- Nl- N 0-007 methylphenyl)(mor N0 4N pholino)methanon H e (4-(5-chloro-4 (methylamino)pyri NH 0 midin-2-ylamino)- ci 233 3-006 methylphenyl)(4- NIN N H hydroxypiperidin- H 1-yl)methanone (4-(4-(ethylamino)- F HN"' 0 5- F (trifluoromethyl)py F F N 234 rimidin-2-ylamino)- N0N O 0.003 3- H 2 (trifluoromethoxy) F phenyl)(morpholin F o)methanone F 120 Ex. Name Structure 'H NMR Ki (4-(4- F HN 0 (methylamino)-5- F N N (trifluoromethyl)py F 235 rimidin-2-ylamino)- N0N O 0.011 3- H 2 (trifluoromethoxy) 0 F phenyl)(morpholin F o)methanone (5-chloro-2 methoxy-4-(4- F NH 0 D D (methylamino)-5- F D 236 (trifluoromethyl)py FF N N) D 0.004 rimidin-2- N O 2 ylamino)phenyl)(p H D D erdeuteromorpholi no)methanone (5-fluoro-2 methoxy-4-(4- F HN (methylamino)-5- F4 N 237 (rifluoromethyl)py F N N.O 27rimidin-2- I 8 .0 ylamino)phenyl)(m H F orpholino)methan F one (4-(4-(ethylamino) 5- F HN O O (trifluoromethyl)py F ' N 238 rimidin-2-ylamino)- F 0.001 5-fluoro-2- 0N 4 methoxyphenyl)(m H F orpholino)methan one [2-Fluoro-5- N F 0 methoxy-4-(4- F NH methylamino-5- F N 1 N 239 trifluoromethyl- F O 0.002 pyrimidin-2- N 'N 9 ylamino)-phenyl]- H morpholin-4-yl methanone 4-(5-Cyano-4- NH F 0 ethylamino- N N pyrimidin-2- N N 0.009 240 ylamino)-2-fluoro- 8 5-methoxy-N,N- NKN dimethyl- H benzamide (4-(4-(ethylamino)- F HN"N o 5-F F 'N - N'T 0.001 21(trifluoromethyl)py FF NN .1 241 rimidin-2-ylamino)- N NF 8 2-fluoro-3- H methoxyphenyl)(m 121 Ex. Name Structure 'H NMR Ki orpholino)methan one (1 S,4S)-2-oxa-5 azabicyclo[2.2.1]h F HN0 eptan-5-yl(4-(4- F (ethylamino)-5- F N N 0.002 242 (trifluoromethyl)py N N F 8 rimidin-2-ylamino)- H 2-fluoro-3- 11 methoxyphenyl)m ethanone (1 S,4S)-2-oxa-5 azabicyclo[2.2.1]h eptan-5-yl(2- F HN 0 fluoro-3-methoxy- F N N 243 4-(4- F 0.011 (methylamino)-5- NIN F 4 (trifluoromethyl)py H O rimidin-2 ylamino)phenyl)m ethanone 5-chloro-4-(5- 0 chloro-4- cI 244 methoxypyrimidin- N NH 0.070 2-ylamino)-2- 9 methoxy-N- N N methylbenzamide H CI 2-(4-((3S,4S)-3,4 difluoropyrrolidine- NH O 1 -carbonyl)-2- N methoxyphenylam NN 0.013 i i45 25ino)-4- N! N 5"F0.1 (methylamino)pyri H F midine-5 carbonitrile (5-chloro-2 methoxy-4-(4- F HN O 0 (methylamino)-5- F N N 246 (trifluoromethyl)py F I 0.005 rimidin-2- N N 0 ylamino)phenyl)(3- H C /O methoxypyrrolidin 1-yl)methanone (2-fluoro-5- F 0 methoxy-4-(4- F HN (methylamino)-5- F N N 247 (trifluoromethyl)py F 0.002 rimidin-2- N 'I N 7 ylamino)phenyl)(3- H /O methoxypyrrolidin 1-yl)methanone 122 Ex. Name Structure 'H NMR Ki 2-fluoro-N-(2 hydroxy-2- F 0 methylpropyl)-5- F HN methoxy-N- F N N 248 methyl-4-(4- F 0.009 (methylamino)-5- NIN 2 (trifluoromethyl)py H rimidin-2- 1 ylamino)benzamid e ((2S,6R)-2,6 dimethylmorpholin F HN F 0 o)(2-fluoro-5- F methoxy-4-(4- F 0.008 249 (methylamino)-5- N 0 (trifluoromethyl)py H rimidin-2 ylamino)phenyl)m ethanone (2-fluoro-5 methoxy-4-(4-(2- F O- 0 F o methoxyethoxy)-5- F (trifluoromethyl)py FF N 0.055 250 rimidin-2- NFI N -O 3 ylamino)phenyl)(m H orpholino)methan one (2-ethoxy-5-fluoro 4-(4- F HN O 0 (methylamino)-5- F N 251 (trifluoromethyl)py F N N 21rimidin-2- I 0.1 ylamino)phenyl)(m H F orpholino)methan one (4-(4-(ethylamino)- F HN" o (trifluoromethyl)py FF N 252 rimidin-2-ylamino)- N N O 0.004 3- H 5 isopropoxyphenyl) 0 (morpholino)meth anone (4-(4-(ethylamino)- F HN" O 5-F (trifluoromethyl)py F N N 253 rim id in-2-ylam ino)- N ~N F 0.206 2-fluoro-3- H isopropoxyphenyl) 0 (morpholino)meth anone 123 Ex. Name Structure 1H NMR Ki (4-(5-chloro-4 (piperidin-1- N 0 yl)pyrimidin-2- C1 N N 0.012 24ylamino)-3-NN .1 methoxyphenyl)(m N"KN orpholino)methan H one (4-(5-chloro-4 (pyrrolidin-1- N O yl)pyrimidin-2- CI N N 0.017 255 ylamino)-3-9 methoxyphenyl)(m N N O orpholino)methan H O one Table 4 Example 2 [4-(5-Cyclopropyl-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyll morpholin-4-vl-methanone HN > BF 3 K HN O Br NN Pd(OAc) 2 N N N N XPhos N N H Cs 2

CO

3 H

H

2 0 PhMe 140 OC 5 To a microwave tube was added (4-(5-bromo-4-(methylamino)pyrimidin-2-ylamino)-3 methoxyphenyl)(morpholino)methanone (56 mg, 0.13 mmol), potassium cyclopropyltrifluoroborate (39 mg, 0.27 mmol), cesium carbonate (0.13 g, 0.40 mmol), toluene (1.8 mL) and water (0.2 mL). The mixture was degassed by nitrogen bubbling for 15 mintues. XPhos (6.4 mg, 0.013 mmol) and palladium acetate (2 mg, 0.01 mmol) was then added. The 10 reaction was heated in a Biotage microwave at 140 oC for 20 minutes. The reaction mixture was filtered and concentrated. The crude product was purified by RP-HPLC to give the desire product (12.6 mg, 25%). Additional compounds made using the above procedure are shown in Table 4 above. Example 3 (4-(5-cyclobutyl-4-(methylamino)pyrimidin-2-vlamino)-3-methoxyphenyl) 15 (morpholino)methanone 124 HN O BF 3 K HN 0 Br NN PN N Pd(OAC) 2 .. N 0 XPhos N N 0 NN N H O11 Cs 2

CO

3 H O

H

2 0 PhMe 140 0C To a microwave tube was added (4-(5-bromo-4-(methylamino)pyrimidin-2-ylamino)-3 methoxyphenyl)(morpholino)methanone (100 mg, 0.24 mmol), potassium cyclobutyltrifluoroborate (177 mg, 1.1 mmol), cesium carbonate (0.23 g, 0.71 mmol), toluene 5 (2.9 mL) and water (0.3 mL). The mixture was degassed by nitrogen bubbling for 15 mintues. di (1-admantyl)-n-butylphosphine (19 mg, 0.053 mmol) and palladium acetate (2.6 mg, 0.026 mmol) was then added. The reaction was sealed and heated at 11 oC for 2 hours. The reaction mixture was filtered and concentrated. The crude product was purified by RP-HPLC to give the desire product (8.1 mg, 8.6%). 10 Additional compounds made using the above procedure are shown in Table 4 above. Example 4: 1-{2-[2-Methoxy-4-(morpholine-4-carbonyl)-phenvlaminol-4-methylamino pyrimidin-5 -yl} -ethanone SnBu 3 HN 0 OEt O HN 0 Br NN (Ph3)4PdN N 'N NO PhMe 'N N 0 H O110 C H O A mixture of (4-(5-bromo-4-(methylamino)pyrimidin-2-ylamino)-3 15 methoxyphenyl)(morpholino)methanone (100 mg, 0.24 mmol), Pd(PPh3)4 (36 mg, 0.03 mmol) and tributylethoxyvinyltin (0.16 mL, 0.47 mmol) in toluene was stirred in a sealed tube at 110 oC for 1 hour. The reaction mix was filtered and concentrated. The reaction mixture was filtered through a pad of silica gel (eluted with 0-100% EtOAc in heptane) to give the crude product. Purification of the crude product was achieved by reverse phase HPLC (9 mg, 10%). Additional 20 compounds made using the above procedure are shown in Table 4 above. Example 5: [3-Methoxy-4-(4-methylamino-5 -prop-1-ynyl-pyrimidin-2-ylamino)-phenyll morpholin-4-vl-methanone 125 HN 0 - SnBu 3 HN 0 Br N N (PPh 3

)

4 PN N N N O PhMe N N O H O 1100C H O A mixture of (4-(5-bromo-4-(methylamino)pyrimidin-2-ylamino)-3 methoxyphenyl)(morpholino)methanone (140 mg, 0.233 mmol), Pd(PPh3)4 (50 mg, 0.04 mmol)and tributyl(prop-1-ynyl)stannane (0.20 mL, 0.66 mmol) in toluene (5 mL) was stirred in 5 a sealed tube at 110 oC for 1 hour. The reaction mixture was filtered and concentrated. Purification of the crude product was achieved by reverse phase HPLC (9 mg, 10%). Additional compounds made using the above procedure are shown in Table 4 above. Example 6: [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-cyclopropyl-phenyll morpholin-4-yl-methanone HN 0 HN 0 CI NI.?-B(OH) 2 CI CI N T :,N N NAN"1K Pd~:1ppf)CI2 N oil, N N N ddP)C12 N H H Br KOAc H Na 2 CO3 MeCN/H 2 0 10 140 C A mixture of [3-Bromo-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone (0.0500 g, 0.117 mmol), potassium acetate (0.0172 g, 0.176 mmol), sodium carbonate (0.0186 g, 0.176 mmol) and 1,1'-bis(diphenylphosphino)ferrocenepalladium (II) chloride (0.00478 g, 0.00585 mmol) were weighed into a microwave vial equipped with a 15 stir bar. Acetonitrile (0.94 mL, 18 mmol) and degassed Water (0.3 mL, 20 mmol) were then added and the reaction mixture was degassed with nitrogen for 4 mins and then heated to 140 0 C under microwave irradiation for 80 min. The mixture was then filtered through celite, eluting with ethyl acetate and concentrated in vacuo. Purification of the crude product was achieved by reverse phase HPLC. 20 Example 7: 5-Chloro-2-methoxy-4- N,N-dimethyl-(4-methylamino-5-trifluoromethyl pyrimidin-2-ylamino)-benzamide HN 0 O Pd 2 (dba) 3 HN O 0 F3C + N Xantphos F 3 C

F

3 CI 1,-DoI I<CI H 2 N Cs 2

CO

3 N C1 1,4-Dioxane H C1 126 A mixture of 4-amino-5-chloro-2-methoxy-N,N-dimethylbenzamide (110 mg, 0.48 mmol), 2-chloro-4-(methylamino)-5-trifluoromethylpyrimidine (50 mg, 0.23 mmol), tris(dibenzylideneacetone)dipalladium (11 mg, 0.012mmol), xantphos (14 mg, 0.024 mmole) and cesium carbonate (235 mg, 0.72 mmol) in 1,4-dioxane was degassed with nitrogen for 5 minutes 5 before heating to IOOC for 2 hours. The cooled mixture was diluted with DCM (10 ml), washed with water, dried (MgSO4) and concentrated in dryness in vacuum. The residue was triturated in diethyl ether to afford the title compound as a pale yellow solid, 45 mg, 47%. Additional compounds made using the above procedure are shown in Table 5 below. Ex. Name Structure 'H NMR Ki 1 H NMR (400 MHz, CDC13): o 8.44 (d, J [4-(4-Ethylamino- = 12.3 Hz, 1H), 8.20 5-trifluoromethyl- F NH F O (s, 1H), 7.84 (s, 1H), pyrimidin-2- F 6.91 (d, J = 5.9 Hz, 0.00 256 ylamino)-2-fluoro- F N N 1H), 5.21 (s, 1H), 2 5-methoxy- N o 3.92 (s, 3H), 3.80 (d, phenyl]-morpholin- H J = 9.1 Hz, 4H), 3.71 4-yl-methanone 3.54 (m, 4H), 3.44 (s, 2H), 1.33 (t, J = 7.2 Hz, 3H). 1 H NMR (400 MHz, 4-(4-Ethylamino-5- CDCl3): 6 8.54 (d, J trifluoromethyl- F N8.2 Hz, 1 H), 8.19 triuorm ethl- F NH O (s, 1H), 7.81 (s, 1H), 257 mna -F N N 7.04-7.00 (m, 2H), 0.00 257 ylamino) F N 5.15 (s, 1H), 3.94 (s, 2 methoxy-phenyl]- NIN .O 3 H), 3.70 (s, 7H), morpholin-4-y- H 3.65-3.55 (m, 3H), methadone 1.31 (t, J = 7.2 Hz, 3H). 1 H NMR (400 MHz, CDC13): 6 8.41 (s, [5-Chloro-4-(5- 1H), 7.96 (s, 1H), chloro-4- 7.49 (s, 1H), 7.30 (s, ethylamino- NH 0 0 1H), 5.35-5.25 (m, pyrimidin-2- cl 1 H), 3.87 (s, 3H), 0.00 258 ylamino)-2-N N 3.77 (d, J = 11.6 Hz, 5 methoxy-phenyl]- N'KN O 4H), 3.59 (dt, J = morpholin-4-yl- H 13.4, 7.2 Hz, 4H), methanone CI 3.32 (d, J = 18.3 Hz, 2H), 1.31 (t, J = 7.3 Hz, 3H). 1 H NMR (400 MHz, [4-(5-Chloro-4- 1CDC3): 6 8.37 (d, J methoxy- F 0 F 0 = 12.2 Hz, 1H), 8.20 pyrimidin-2- F N N (s, 1H), 7.81 (s, 1H), 0.01 259 ylamino)-2-fluoro- F 0 6.93 (d, J = 5.9 Hz, 5-methoxy- NIN 1H), 4.10 (s, 3H), 92 phenyl]-morpholin- H O 3.94 (s, 3H), 3.80 (d, 4-yl-methanone J = 8.5 Hz, 4H), 3.68 (s, 2H), 3.44 (s, 2H).

127 Ex. Name Structure 'H NMR Ki 1 H NMR (400 MHz, hloro-4-txy- N o o DMSO): 6 8.88 (s, chlro-4-mety- 0 1H), 8.31 (s, 1H), 7.70 260 pyrimidin-2- cl NN (s, 1H), 7.32 (s, 1H), 0.04 methoxy-phenyl]- N 0 398 (s, 1H), 3.80 (s, 7 morpholin-4-yl- H 3H), 3.61 (m, 4H), methanone cl 3.53 (m, 2H), 3.17 (m, 2H). 1 H NMR (400 MHz, [3-Chloro-4-(5o- 0 DMSO): 6 9.03 (s, chloro-4-methoxy- 1H), 8.28 (,1H,79 pyrimidin-2- Nd NJ 1 8., 1H), 7.92 0.04 261 ylamino)-phenyl]- N (d ,J83 1H,75 ylamio)-pN.yl]- 0 (s, 1 H), 7.39 (d, J 7 morpholin-4-yl- '9.8, H), 3.95 (m methanone CI ,3H), 3.56 (m, 8H). [2-Chloro-5- 1H NMR (400 MHz, 4-(4- F O C O DMSO) o 8.98 (s, methoxy-4-(- F 0C 01H), 8.56 (s, 1 H), 8.15 trfrmethy- F4 kN N"^ (s, 1 H), 7.10 (s, 1 H), 0.02 262 trifluoromethyl- ' I 4.01 (s, 3H), 3.87 (s, pyrimidin-2- N' N O 3H), 3.73 - 3.48 (m, ylamino)-phenyl]- H 6H), 3.23 - 3.15 (m, morpholin-4-yl- 3H). methanone [3-Methoxy-4-(4 methoxy-5- F 0 0 trifluoromethyl- F 7 -N N 0.02 263 pyrimidin-2- F O0O ylamino)-phenyl]- N N morpholin-4-yl- H methanone 1 H NMR (400 MHz, {4-[5-Chloro-4- DMSO): 6 8.32 (m, (tetrahyd ro-pyran- oa o 0 2H), 8.06 (d, J = 8.2, 4-yloxy)-pyrimidin- cl N 1H), 7.08 (s, 1H), 7.02 0.03 264 2-ylamino]-3- N N (d, J = 8.2, 1H), 5.26 3 methoxy-phenyl}- N N' O (m, 1H), 3.86 (m, 5H), morpholin-4-yl- H 3.61 (m, 4H), 3.50 (m, methanone 0 N 6H), 2.05 (m, 2H), 1.68 (m, 2H). Table 5 Example 8: 5-Chloro-N-(2-hydroxy-2-methyl-propyl)-2-methoxy-4-(4-methylamino-5 trifluoromethyl-pyrimidin-2-ylamino)-benzamide HN O 0 HN O 0

F

3 C A N + OH p-toluenesulphonic acid F 3 C N OH NCI H 2 N 1,4-Dioxane N N CI H CI 5 A mixture 4-amino-5-chloro-2-methoxy-N-(2-methyl-propan-2-ol)-benzamide (95 mg, 0.35 mmol ), 2-chloro-4-(methylamino)-5-trifluoromethylpyrimidine (50 mg, 0.23mmol) and p- 128 toluenesulphonic acid monohydrate (49 mg, 0.26mmol) in 1,4-dioxane (5 ml) was stirred at 100OC for 18 hrs. The solvent was removed by evaporation in vacuum and the residue partitioned between DCM and aq K2C03 solution. The organic phase was separated, concentrated to dryness in vacuum and the crude material purified by RP- HPLC which afforded 5 the title compound as a cream solid, 57 mg, 55%. Additional compounds made using the above procedure are shown in Table 6 below. Example 9 (3-(2-fluoroethoxy)-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone F NH F NH 0 F C + HN O2-methoxyethanol FN F N O F 10 A mixture of 2-chloro-N-methyl-5-(trifluoromethyl)pyrimidin-4-amine (0.10 g, 0.47 mmol), (4-amino-3-(2-fluoroethoxy)phenyl)(morpholino)methanone (0.13 g, 0.47 mmol), trifluoroacetic acid (0.07 mL, 0.9 mmol) in 2-methoxyethanol (2.5 mL) was stirred at 95 oC for 6 hours. The reaction was the concentrated. The crude product was purified by reverse phase HPLC to give the title compound (61 mg, 29%). Additional compounds made using the above 15 procedure are shown in Table 6 below. Example 10 (2-fluoro-3-methoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone 0 1) morpholine, HBTU DIEA F NH O2 OH 2) Pd/C, H 2 HF F 0 2 N-- F H 2 NJ; F oFlNC F NH 0 TFA F 2-methoxyethanol F N N F N:' N F H To a suspension of 2-fluoro-3-methoxy-4-nitrobenzoic acid (180 mg, 0.97 mmol) in 20 DCM (8 mL) was added morpholine (0.17 mL. 1.9 mmol), DIEA (0.25 mL) and HBTU (0.4 g, 1.05 mmol). The reaction was stirred at room temperature for 18 hours. The reaction was then diluted with water and extracted with DCM (3x). The combined extracts were washed with water, dried over Na2SO4, filtered and concentrated. The crude product was purified by flash 129 chromatography to give (2-fluoro-3-methoxy-4-nitrophenyl)(morpholino)methanone (0.20 g, 83%). A suspenion of (2-fluoro-3-methoxy-4-nitrophenyl)(morpholino)methanone (0.20 g) and palladium on carbon (0.1 g, 10 wt%) in ethanol was stirred under hydrogen for 18 hours. The 5 reaction then filtered through celite and concentrated to give (4-amino-2-fluoro-3 methoxyphenyl)(morpholino)methanone. A mixture of (4-amino-2-fluoro-3-methoxyphenyl)(morpholino)methanone (0.18 g, 0.72 mmol) and 2-chloro-N-methyl-5-(trifluoromethyl)pyrimidin-4-amine (0.10 g, 0.47 mmol) in a solution of 2-methoxyethanol (2 mL) and TFA (0.055 mL) was stirred at 95 oC for 2 hours. The 10 reaction was concentrated and purified by reverse phase HPLC to give the title compound. Additional compounds made using the above procedure are shown in Table 6 below. Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, 5-Chloro-N-(1- DMSO): 6 8.88 (s, cyano- F NH O O 1H), 8.64 (s, 1H), cyclopropyl)-2- F 8.27 (s, 1H), 8.08 methoxy-4-(4- F N NH (S, 1H), 7.82 (s, 1H), 0.004 265 methylamino-5- 7.39 (d, J = 5.1 Hz, 2 trifluoromethyl- N 'IN 1H), 3.93 (s, 3H), pyrimidin-2- C1 2.95 (t, J = 4.3 Hz, ylamino)- 3H) 1.61-1.55 (m, benzamide 2H), 1.35-1.29 (m, 2H). 'H NMR (400 MHz, 5-Chloro-N-(1- DMSO): 6 8.62 (s, cyano- F NNH 1H), 8.26 (s, 1H), cyclopropyl)-2- 8.18 (d, J = 5.2 Hz, methoxy-4-(4- F N NH 1H), 8.05 (s, 1H), 0.004 266 methylamino-5- F 7.87 (s, 1H), 7.36 6 trifluoromethyl- N (d, J = 5.1 Hz, 1H), pyrimidin-2- H 3.94 (s, 3H), 2.95 ylamino)- CI (d, J = 4.4 Hz, 3H), benzamide 2.84 (d, J = 4.6 Hz, 3H). 'H NMR (400 MHz, DMSO): 6 8.64 (s, 1H), 8.24 (s, 1H), [5-Chloro-2- 7.92 (s, 1H), 7.37 methoxy-4-(4- (s, 1H), 7.31 (t, J = methylamino-5- F NH O 0 5.5 Hz, 1H), 4.40 (d, trifluoromethyl- F J = 13.1 Hz, 1H), 0.008 267 pyrimidin-2- F 3.84 (s, 3H), 3.55 ylamino)-phenyl]- N0N o (s, 2H), 3.21 (m, 0 (2,6-dimethyl- H cl 1H), 2.93 (d, J = 4.4 CI morpholin-4-yl)- Hz, 3H), 2.82 -2.70 methanone (m, 1H), 2.45 (m, 1H), 1.17 (d, J = 6.1 Hz, 3H), 1.03 (d, J = 6.3 Hz, 3H).

130 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [3-Methoxy-4-(4- DMSO): 6 8.34 (s, pyrrolidin-1-yl-5- F N 0 1H), 8.27 (d, J = 8.2, 268 pyrimidin-2- F N N 1 H), 8.06 (s, 1H), 0.019 pyrimidn-2- F I AN 7.0 8 (s, I H), 7.0 3 (d, ylamino-pyl- N N O J = 8.2, 1H), 3.90 (s, methanone H Br 3H), 3.56 (m, 12H), methanne Br1.93 (in, 4H). 1 H NMR (400 MHz, DMSO) 6 8.36 (d, J = 8.3 Hz, 1H), 8.19 [3-Cyclobutoxy-4- F NH 0 (s, 1H), 8.02 (s, 1H), 7.25 (s, 1H), 7.01 (d, (4-methylamino-5- F N J = 8.3 Hz, 1 H), 6.88 trifluoromethyl- FI 269 pyri m ey-FN 0 (s, 1H), 4.81 (dd, J= 0.002 NIN 14.2, 7.0 Hz, 1H), 5 ylamino)-phenyl]- H 3.55 (dm, 8H), 2.93 methadone ~ (d, J = 4.3 Hz, 3H), 2.45 (m, 2H), 2.24 2.02 (m, 2H), 1.81 (m, 1H), 1.66 (m, 1 H). TH NMR (400 MHz, N-(3,3-Difluoro- DMSO) 6 8.69 (d, J cyclobutyl)-3- F NH 0 = 6.4 Hz, 1 H), 8.41 methoxy-4-(4- F "N N (d, J = 8.3 Hz, 1H), 270 methylamino-5- F F 8.21 (s, 1H), 8.11 (s, 0.001 trifluoromethyl- NIN F 1H), 7.57 - 7.46 (m, 5 pyrimidin-2- H O 2H), 7.28 (s, 1H), ylamino)- 4.28 (br, 1 H), 3.94 benzamide (s, 3H), 2.93 (m, 4H), 2.77 (br, 2H). 1 H NMR (400 MHz, DMSO) 6 8.98 (d, J lsNH= 6.3 Hz, 1H), 8.41 3-Methoxy-4-(4- F NH O (d, J = 8.4 Hz, 1H), methylamino-5- F 8.21 (s, 1H), 8.11 (s, trifluoromethyl- F N NH 1H), 7.59 - 7.47 (m, 0.003 271 pyrimidin-2- N 2H), 7.27 (s, 1H), ylamino)-N- N N ('> 5.01 (dd, 1H), 4.78 oxetan-3-yl- H0 (t, J = 6.8 Hz, 2H), benzamide 4.60 (t, J = 6.4 Hz, 2H), 3.94 (s, 3H), 2.93 (d, J = 4.2 Hz, 3H) 'H NMR (400 MHz, [3-Methoxy-4-(4- DMSO) 6 8.31 (d, J methylamino-5- F NH 0= 8.3 Hz, 1H), 8.19 trifluoromethyl- F (s, 1H), 8.07 (s, 1H), 272 pyrimidin-2- F N N 7.23 (s, 1H), 7.05 (s, 0.001 ylamino)-phenyl]N N . O H), 6.99 (d, J= 8.3 7 (8-oxa-3-aza- H Hz, 1 H), 4.30 (m, bicyclo[3.2.1]oct- ON 6H), 3.90 (s, 3H), 3-yl)-methanone 2.92 (d, J= 4.3 Hz, 3H), 1.73 (m, 4H).

131 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, [3-Methoxy-4-(4- DMSO) o 8.34 (d, J methylamino-5- F NH O = 8.3 Hz, 1 H), 8.20 trifluoromethyl- F (s, 1H), 8.08 (s, 1H), 273 pyriF N N 7.17 (m, 3H), 4.63 0.003 ylamino)-phenyl]N (m, 2H), 3.91 (s, 3 (2-oxa-5-aza- H 3H), 3.88 - 3.41 (m, bicyclo[2.2.1]hept- 4H), 2.92 (d, J= 4.2 5-yl)-methanone Hz, 3H), 1.97 - 1.65 (m, 2H). [3-Methoxy-4-(4- F NH 0 methylamino-5- FN trifluoromethyl- N N 274 pyrimidin-2- F Nn 0004 ylamino)-phenyl]- H pyrrolidin-1-yl- 0 methanone 1 H NMR (400 MHz, N,N-Diethyl-3- F NH O DMSO) o 8.26 (d, J methoxy-4-(4- F -8.1 Hz, 1H), 8.18 methylamino-5- F N N\ (s, 1H), 8.07 (s, 1H), 275 trifluoromethyl- F 7.20 (s, 1H), 7.00 (s, 0.003 25 riuometh- WN 1H), 6.94 (d, J = 8.3 3 pyrimidin-2- H Hz, 1H), 3.89 (s, ylami - 3H), 2.91 (d, J = 4.2 Hz, 3H), 1.12 (s, 6H). 'H NMR (400 MHz, (4-Dimethylamino- DMSO) 6 8.28 (d, J piperidin-1-yl)-[3- = 8.2 Hz, 1H), 8.19 methoxy-4-(4- F NH (s, 1H), 8.07 (s, 1H), methylamino-5- F N N 7.22 (s, 1H), 7.04 (s, 0.000 276 trifluoromethyl- F 1H), 6.98 (d, J = 8.3 8 N N N Hz, 1H), 3.89 (s, ylami-phenyl]- H 3H), 2.92 (m, 7H), nethanone 2.32 (s, 1H), 2.18 (s, 6H), 1.76 (s, 2H), 1.34 (m , 2H). H NMR (400 MHz, (2,6-Dimethyl- DMSO) 6 8.31 (d, J morpholin-4-yl)-[3- F NH - 8.4 Hz, 1H), 8.19 methoxy-4-(4- F (s, 1H), 8.08 (s, 1H), 277 methylamino-5- F N N 7.23 (s, 1H), 7.07 (s, 0.004 trifluoromethyl- N N o 1H), 7.01 (d, J = 8.3 9 pyrimidin-2- H Hz, 1H), 3.89 (s, ylamino)-phenyl]- 0 N 3H), 3.55 (s, 2H), methanone 2.92 (d, J= 4.1 Hz, 3H), 1.08 (s, 6H). 1-[3-Methoxy-4-(4- 'H NMR (400 MHz, methylamino-5- F NH 0 DMSO) 6 8.30 (d, J trifluoromethyl- F N N -8.2 Hz, 1H), 8.19 0.001 278 pyrimidin-2- F (s, 1H), 8.08 (s, 1H), 7 ylamino)-benzoyl]- N N , 7.22 (s, 1H), 7.07 (s, piperidine-4- H 1 1H), 7.01 (d, J= 7.9 carbonitrile Hz, 1H), 3.90 (s, 132 Ex. Name Structure 'H NMR Ki 3H), 3.72 (s, 2H), 3.36 (s, 2H), 3.15 (s, 1H), 2.92 (d, J= 4.2 Hz, 3H), 1.90 (s, 2H), 1.75 (m, 2H). 'H NMR (400 MHz, [3-Methoxy-4-(4- DMSO) 6 8.31 (d, J methylamino-5- F NH 0= 8.3 Hz, 1H), 8.19 trifluoromethyl- F ,N N F (s, 1H), 8.08 (s, 1H), 279 pyrimidin-2- F N7 N F .23 (s, 2H), 7.05 (s, 0.002 ylamino)-phenyl]- F 1H), 6.99 (d, J = 8.2 0 [4-(2,2,2-trifluoro- Hz, 1H), 3.89 (s, ethyl)-piperazin-1- 3H), 3.52 (s, 4H), yl]-methanone 3.23 (m, 2H), 2.92 (d, 3H), 2.65 (s, 4H). 1 H NMR (400 MHz, DMSO) 6 8.28 (d, J [3-Methoxy-4-(4- = 8.3 Hz, 1H), 8.19 methylamino-5- F NH (s, 1H), 8.07 (s, 1H), trifluoromethyl- F N - N 7.22 (s, 1H), 7.05 (s, 280 pyrimidin-2- F 1H), 6.98 (d, J = 8.0 0.001 ylamino)-phenyl]- NIN o Hz, 1H), 3.89 (s, 6 (4-methoxy- H 0 3H), 3.75 (m, 4H), piperidin-1-yl)- 3.44 (s, 1H), 3.26 (s, methadone 3H), 2.91 (d, J= 4.1 Hz, 3H), 1.84 (s, 2H), 1.46 (s, 2H). 'H NMR (400 MHz, 3-Methoxy-N-(2- F NH O DMSO) 6 8.56 methoxy-ethyl)-4- F 8.30 (m, 2H), 8.21 (4-methylamino-5- F N NH (s, 1H), 8.09 (s, 1H), 0.002 281 trifluoromethyl- N 7.51 (m, 2H), 7.26 3 pyrimidin-2- H (s, 1H), 3.93 (s, 3H), ylam i no)- O 3.44 (m, 2H), 3.27 benzamide (m, 5H), 2.93 (d, J= 4.2 Hz, 3H). 'H NMR (400 MHz, DMSO) 6 8.37 (d, J 3-Methoxy-4-(4- F NH 0 = 8.4 Hz, 1 H), 8.20 methylamino-5- F-'T -(s, 1H), 8.16 - 8.01 trifluoromethyl- F | N NH (m, 2H), 7.51 (m, 282 pyrimidin-2- I 2H), 7.27 (s, 1H), 0.000 282 pyrimidin- N , N 3.93 (s, 3H), 3.74 (s, 6 ylamino)-N-(1- H 1H), 2.93 (d, J = 4.2 methyl-pipendin-4-O N Hz, 3H), 2.78 (d, yl)-benzamnide | 2H), 2.17 (s, 3H), 1.94 (t, 2H), 1.76 (m, 2H), 1.60 (m, 2H). N-(4,4-Difluoro- F NH O H NMR (400 MHz, cyclohexyl)-3- DMSO) 6 8.38 (d, J methoxy-4-(4- F N - NH = 8.4 Hz, 1 H), 8.29 methylamino-5- F 8.11 (m, 2H), 8.09 0.001 283 trifluoromethyl- N N (s, 1 H), 7.63 - 7.39 1 pyrimidin-2- H (m, 2H), 7.27 (s, ylamino)- 1 H), 3.99 (m, 1H), benzamide F F 3.93 (s, 3H), 2.93 (d, 133 Ex. Name Structure 'H NMR Ki J = 4.1 Hz, 3H), 2.06 (s, 4H), 1.88 (m, 2H), 1.65 (m, 2H). [4-(5-Chloro-4- NH 0 methylamino- c N pyrimidin-2- N N 284 ylamino)-3- N0N 82 (oxetan-3-yloxy)- H phenyl]-morpholin- 0 4-yl-methanone 1 H NMR (400 MHz, DMSO) 6 8.37 (d, J [3- 8.2 Hz, 1 H), 8.20 Cyclopropylmetho (s, 1H), 8.03 (s, 1H), xy-4-(4- F NH O 7.30 (d, J= 4.4 Hz, F H), 7.05 (s, 1H), 285 thylam o-.. F F N N 7.04 - 6.98 (m, 1H), 0.006 pyrimidin-2- N"N O 3.95 (d, J = 7.0 Hz, 46 ylamino)-phenyl]- H A 2H), 3.55 (dm, 8H), morphol in-4-yI- 0,, 2.93 (d, J= 4.4 Hz, moethanone 3H), 1.37 - 1.20 (m, 1H), 0.66 - 0.55 (m, 2H), 0.37 (q, J = 4.5 Hz, 2H). "H NMR (400 MHz, DMSO) 6 8.31 (d, J [3- = 8.2 Hz, 1H), 8.19 Cyclobutylmethox (s, H), 8.01 (s, 1H), y4(-F NH 0 7.27 (d, J =4.3 Hz, inethylainino-5- F 1 H), 7.08 (d, J= 1.4 286 trifluoroethyl- F N N Hz, 1H), 7.02 (d, J= 0.005 pyrimidin-2- N N O 8.2 Hz, 1H), 4.07 (d, 19 ylamino)-phenyl]- H Odbr6 8HH, 21 ), 3.56 morpholin-4-yl- = 4.3 Hz, 3H), 2.78 methadone (dd, 1H), 2.18 - 1.99 (m, 2H), 1.89 (m, 4H). N-Ethyl-3 methoxy-N- F NH 0 methyl-4-(4- F 287 methylamino-5- F N N 27trifluoromethyl- F N pyrimidin-2- N ylamino) benzamide [4-(5-Bromo-4- NH o o 'H NMR (400 MHz, methylamino- DMSO): 6 8.10 (s, -2thlinn- Br N N -, 1 H), 8.05 (s, 1 H), pyrimidin-2- N 7.99 (s, 1H), 7.29 (s, 0.002 288 ylamino)-5-chloro- N'5k -.

O 1H), 7.18 (s, 1H), 6 2-methoxy-

.

H 3.81 (m, 3H), 3.56 phenyl]-morpholin- C1 (m, 6H), 3.18 (m, 4-yl-methanone 2H), 2.92 (m, 3H).

134 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, DMSO): 6 8.71 (s, [3-Cyclopropyl-4- F NH O 1H), 8.14 (s, 1H), (4-methylamino-5- F NH 0 7.86 (d, J = 7.8, 1 H), trifluoromethyl- F N N 7.22 (d, J = 8.0, 1 H), 0.020 289 pyrimidin-2- F 0 7.02 (s, 2H), 6.65 (s, 0 ylamino)-phenyl]- NIN 1 H), 3.59 (m, 4H), morpholin-4-yl- H 3.48 (m, 4H), 2.86 methanone (m, 3H), 2.04 (m, 1H), 0.93 (m, 2H), 0.61 (m, 2H). 'H NMR (400 MHz, [3-Bromo-4-(4- DMSO): 6 8.64 (s, methylamino-5- F NH 0 1H), 8.16 (s, 1H), trifluoromethyl- F N) N N 8.00 (d, J = 8.3, 1 H), 0.007 290 pyrimidin-2- F N 7.69 (s, 1H), 7.42 (d, ylamino)-phenyl]- N N O*) 0 J = 8.3, 1 H), 7.15 (d, morpholin-4-yl- H Br J = 3.4, 1 H), 3.55 methanone (m, 8H), 2.86 (d, J = 4.2, 3H). [3-Chloro-4-(4- 'H NMR (400 MHz, methylamino-5- F NH 0 DMSO): 6 8.83 (s, trifluoromethyl- F )1H), 8.17 (s, 1H), 291 pyrimidin-2- "F N N 8.02 (d, J = 8.4, 1 H), 0.017 ylamino)-phenyl]- NL<N 0 7.55 (s, 1H), 7.3 9 (d, morholn-4I HP J = 7.6, 1 H), 7.22 (s, morpholin-4-yl- H cI 1H), 3.60 (s, 4H), methadone 2.86 (d, J = 4.2, 3H). 1H NMR (400 MHz, [2-Chloro-5- DMSO) o 8.51 (s, methoxy-4-(4- F NH CI 0 1H), 8.24 (s, 1H), methylamino-5- F 8.12 (s, 1H), 7.32 (d, 292trifluoromethyl- F N N J = 4.0, 1 H), 7.06 (s, 0.002 pyrimidin-2- N O 1H), 3.89 (s, 3H), 0 ylamino)-phenyl]- H 3.71 - 3.49 (m, 6H), morpholin-4-yl- O... 3.24 - 3.15 (m, 2H), methanone 2.94 (d, J = 4.3, 3H). 1H NMR (400 MHz, [2-Chloro-4-(5- DMSO) 6 8.58 (s, chloro-4- NH CI O 1H), 8.00 (s, 1H), methylamino- C07.71 (s, 1H), 7.40 pyrimidin-2- Ci N "' N (m, 1H), 7.02 (s, 0.002 293 yrimino-2- 0 1 H), 3.90 (s, 3 H),7 ylamino)-5- N' N O 3.70 - 3.60 (m, 4H), methoxy-phenyl]- H 3.60 - 3.48 (m, 2H), morpholin-4-yl- 0 3.23 - 3.15 (m, 3H), methadone 2.92 (d, J = 4.5, 3H). [4-(5-Bromo-4- IO C1 0 1H NMR (400 MHz, methoxy- DMSO) 6 8.44 (s, pyrimidin-2- Br N 1 N 1 H), 8.36 (s, 1H), 0.009 294 ylamino)-2-chloro- 0 8.30 (s, 1H), 7.06 (s, 4 5-methoxy- N N 1 H), 4.00 (s, 3H), phenyl]-morpholin- H 3.88 (s, 3H), 3.72 4-yl-methanone 3.59 (m, 4H), 3.56 135 Ex. Name Structure 'H NMR Ki (d, J = 3.9, 2H), 3.23 - 3.14 (m, 2H). 1H NMR (400 MHz, (5-chloro-4-(5- DMSO) 6 8.11 (s, chloro-4- 1H), 7.99 (s, 1H), etrhyamino)pyri 0 7.97 (s, 1H), 7.38 295 midin-2-ylamino)- (dd, J = 9.2, 4.6, 0.006 295mdn2aio- 1~ ~ H), 7.29 (s, 1IH), 0 methoxyphenyl) HN N N O O 3.82 (s, 3H), 3.60 (s, orpholino)methan H | 4H), 3.52 (t, J = 4.3, one 2H), 3.17 (s, 2H), 2.92 (d, J = 4.6, 3H). 1H NMR (400 MHz, [5-Chloro-2- DMSO) 6 8.59 (s, methoxy-4-(4- F NH o H), 8.20 (s, H), methyamin-5- NH -0 07.8 8 (s, 1 H), 7.32 (s, 296 thdar o-- F N" 1 H), 7.25 (dd, s 4 0.002 26pyrimidin-2- F1N.0, 7.5, 1 H), 3.81 0 ylamno)phenl]-Nl N O(s, 3H), 3.60 (s, 4H), ylamino)-phenyl]- H 3.53 (t, J = 4.4, 2H), morpholin-4-yl- Cl 3.17 (s, 2H), 2.90 (d, methadone J = 4.3, 3H). 1H NMR (400 MHz, [2-Fluoro-3- DMSO) 6 8.49 (s, methoxy-4-(4- F NH o 1H), 8.20 (s, 1H), methylamino-5- F 8.11 (d, J = 8.5, 1H), 297 trifluoromethyl- FN 7.25 (d, J = 3.6, 1 H), 0.014 pyrimidin-2- N N F 7.08 (t, J = 7.8, 1H), 5 ylamino)-phenyl]- H 3.91 (s, 3H), 3.59 morpholin-4-yl- 0 (m, 6H), 2.91 (d, J = methanone 4.2, 3H). 1H NMR (400 MHz, DMSO) 6 8.38 (d, J = 8.3, 1H), 8.19 (s, [3-(2-Fluoro- 1H), 8.07 (s, 1H), ethoxy)-4-(4- F NH 0 7.24 (d, J = 4.3, 1 H), methylamino-5- F 7.13 (s, 1H), 7.05 (d, 298 trifluoromethyl- F N N J = 8.3, 1 H), 4.91 - 0.002 pyrimidin-2- N N O 4.83 (m, 1 H), 4.80 - 4 ylamino)-phenyl]- H 4.72 (m, 1H), 4.47 morpholin-4-yl- F 4.39 (m, 1 H), 4.39 methanone 4.29 (m, 1H), 3.56 (d, J = 37.5, 8H), 2.93 (d, J = 4.4, 3H). (4-(5-chloro-4- o0 1H NMR (400 MHz, methoxypyrimidin- CI DMSO) 6 8.32 (s, methxypriiidin ci~ N N 1 H), 8.26 (s, 1IH), 299 etypeny)( N N N 8.16 (d, J = 8.2 Hz, 0.006 yrroldin-l N N1 H), 7.18 (s, 1 H), yrrolidin-1- H 7.15 (d, J = 8.3 Hz, yl)methanone ON 1H), 4.00 (s, 3H), 136 Ex. Name Structure 'H NMR Ki 3.89 (s, 3H), 3.46 (t, J = 6.6 Hz, 4H), 1.83 _s, 4H) H NMR (400 MHz, DMSO) 6 8.34 (d, J [5-Ethoxy-2-fluoro- = 12.2 Hz, 1H), 8.24 4-(4-methylamino- F NH F 0 (s, 1H), 8.04 (s, 1H), 5-trifluoromethyl- F N N 7.35 (d, J= 4.3 Hz, 300 pyrimidin-2- F I 1H), 7.02 (d, J = 6.2 0.009 ylamino)-phenyl]- NIN Hz, 1H), 4.15 (q, J morpholin-4-yl- H 6.9 Hz, 2H), 3.59 (m, methanone 6H), 2.95 (d, J = 4.4 Hz, 3H), 1.39 (t, J 6.9 Hz, 3H). 'H NMR (400 MHz, 3-Methoxy-N-(2- DMSO) o 8.27 (d, J methoxy-ethyl)-N- F NH - 8.2 Hz, 1 H), 8.18 methoy-et-N- F' NH 0 (s, 1 H), 8.0 6 (s, 1 H), methylamino-5- F N N/ 7.19 (d, J= 4.3 Hz, 0.005 301 F 1H), 7.07 (s, 1H), trifluoromethyl- N N 7.03 - 6.95 (m, 1 H), 1 pyrimidin-2- H 3.88 (s, 3H), 3.51 (s, benzamide 4H), 3.26 (s, 3H), 2.98 (s, 3H), 2.91 (d, J = 4.4 Hz, 3H). 1 H NMR (400 MHz, DMSO) o 8.21 (d, J 4-(4- Ethyl amino-5- F -8.2 Hz, 1H ), 8.18 trifluoromethyl- FHN 0'~ (s, 1 H), 8.0 6 (s, 1 H), pyrimidin-2- F N 7.19 (t, J= 5.4 Hz, 302 ylamino)-3- F N N 1H), 7.07 (s, 1H), 0.002 methoxy-N-(2- N 6.98 (dd, J= 8.2, 1.5 3 methoxy-ethyl)-N- H Hz, 1H), 3.88 (s, methyl-benzamide O . O- 3H), 3.62 - 3.40 (m, 6H), 3.25 (s, 3H), 2.98 (s, 3H), 1.14 (t, SJ= 7.1 Hz, 3H). 1H NMR (400 MHz, 2-Fluoro-5- DMSO) 6 8.34 methoxy-N-(2- F NH F O 8.25 (m, 1H), 8.24 methoxy-ethyl)-N- (s, 1H), 8.09 (s, 1H), methyl-4-(4- F N N/ 7.31 (s, 1H), 6.98 (t, 0.005 303 methylamino-5- F J = 6.3 Hz, 1 H), 3.88 trifluoromethyl- N N (d, J= 6.9 Hz, 3H), 9 pyrimidin-2- H 3.65 - 3.52 (m, 2H), ylamino)- 1 N. 3.44 - 3.33 (m, 2H), benzamide 3.21 - 3.15 (m, 2H), 3.02 - 2.89 (m, 6H). 4-(4 Ethl ami no5- H NMR (400 MHz, 4-(Eoromethylo-5 F HNN F 0 DMSO) 6 8.28 pyrimidin-2- F NN -- N N 8.19 (m, 2H), 8.09 304 ylaiino)-2-fluoro- F N (s, 1H), 7.33 (d, J= 0.001 5-methoxy-N-(2-

N

2 N 4.9 Hz, 1H), 6.98 (t, 6 methoxy-ethyl)-N- H J = 6.3 Hz, 1 H), 3.88 methyl-benzamide /O 0 . (d, J = 7.0 Hz, 3H), ____ ____ _____ ___ _____ ____ _____ ____ ____ 3.65 - 3.33 (mn, 6H), _ _ _ 137 Ex. Name Structure 'H NMR Ki 3.29 - 3.15 (m, 3H), 2.96 (d, J = 29.9 Hz, 3H), 1.17 (t, J = 7.0 Hz, 3H). 1 H NMR (400 MHz, DMSO) 6 8.34 [2-Fluoro-5- 8.26 (m, 1H), 8.24 methoxy-4-(4- F NNH F 0 (s, 1H), 8.09 (s, 1H), methylamino-5- 7.31 (s, 1H), 7.07 trifluoromethyl- F ) N ,, N 6.96 (m, 1H), 4.22 305 pyrimidin-2- (s, 1 H), 3.63 - 3.53 0.003 ylamino)-phenyl]- N N (m, 1 H), 3.44 - 3.35 0 ((S)-2- H O, , 0 methoxymethyl- /0 (2, 1H), 3.30 (s, pyrrolidin-1-yl)- 3.09 - 3.00 (m, 2H), nethanone 2.94 (d, J= 4.3 Hz, 3H), 2.06 - 1.65 (m, 5H). 'H NMR (400 MHz, DMSO) 6 8.29 [4-(4-Ethylamino- 8.20 (m, 2H), 8.12 5-trifluoroimethyl- F HN F O 8.06 (m, 1 H), 7.38 pyrimidin-2- 7.30 (m, 1 H), 7.07 ylamino)-2-fluoro- F N N 6.96 (m, 1 H), 4.27- 0.000 306 5-methoxy- F 4.17 (m, 1H), 3.63 - 0.6 phenyl]-((S)-2- N N 3.34 (m, 4H), 3.30 6 methoxymethyl- H O O (s, 2H), 3.27 - 3.20 pyrrolidin-1-yl)- (m, 1 H), 3.13 - 2.99 methanone (m, 2H), 2.04 - 1.64 (m, 5H), 1.17 (t, J 7.0 Hz, 3H). TH NMR (400 MHz, N-Ethyl-4-(4- DMSO) o 8.27 ethylamino-5- F HN" F 0 8.20 (m, 2H), 8.09 trifluoromethyl- F (s, 1H), 7.33 (t, J= 307 pyrimidin-2- F N N 5.5 Hz, 1H), 6.96 (d, 0.001 ylamino)-2-fluoro- NJ = 6.2 Hz, 1H), 3.88 4 5-methoxy-N-(2- H (s, 3H), 3.63 - 3.32 methoxy-ethyl)- 1O ON (m, 8H), 3.27 - 3.13 benzamide (m, 3H), 1.20 - 0.98 M, 6H). H NMR (400 MHz, N-Ethyl-2-fluoro-5- DMSO) 5 8.32 methoxy-N-(2- F NH F 0 8.25 (m, 1 H), 8.24 methoxy-ethyl)-4- F (s, 1H), 8.09 (s, 1H), (4-methylamino-5- I N N 7.34 - 7.27 (m, J 0.003 308 F 4.2 Hz, 1H), 6.96 (d, triuoronethylN N J = 6.2 Hz, 1H), 3.88 ylamidno)- H (s, 3H), 3.62 - 3.15 benzamide 0 0 N (m, 9H), 2.93 (d, J = 4.4 Hz, 3H), 1.18 0.97 (m, 3H).

138 Ex. Name Structure 'H NMR Ki 'H NMR (400 MHz, DMSO) o 8.29 (d, J [5-Ethoxy-4-(4- = 12.2 Hz, 1H), 8.23 ethylamino-5- F HN F 0 (s, 1H), 8.04 (s, 1H), trifluoromethyl- F N N 7.37 (t, J= 5.3 Hz, 0.002 309 pyrimidin-2- F 1 H), 7.02 (d, J = 6.2 ylamino)-2-fluoro- N N N O Hz, 1H), 4.15 (q, J= phenyl]-morpholin- H 6.9 Hz, 2H), 3.71 4-yl-methanone 3.44 (m, 9H), 1.38 (t, J = 6.9 Hz, 3H), 1.18 (t, J= 7.1 Hz, 3H). 1 H NMR (400 MHz, DMSO) 6 8.38 8.31 (m, 1H), 8.21 8.17 (s, 1H), 7.97 (4-(4-(ethylamino)- 7.92 (s, 1H), 7.30 5-F HN' 0 7.23 (t, J = 5.4 Hz, 5- F H), 7.10 -7.06 (d, (trifluoromethyl)py F N NJ = 1.6 Hz, 1 H), 7.02 30rrnmidfi-2-yI- N. 0 -. ~ 6.9 6 (d d, J = 8.3, 0.004 310 a i o-3- N N5 -- O 0 isopropoxyphenyl) 1.6 Hz, 1 H), 4.79 (morpholino)meth 4.66 (m, 1 H), 3.64 anone 3.56 (m, 4H), 3.57 3.41 (m, 6H), 1.35 1.29 (d, J= 6.0 Hz, 6H), 1.21 - 1.09 (t, J = 7.1 Hz, 3H). 1 H NMR (400 MHz, DMSO) 6 8.22 8.20 (s, 1H), 8.20 (2-fluoro-3- 8.14 (m, 2H), 7.32 isopropoxy-4-(4- F FHN 0 7.27 (M, 1IH), 7.13 (inethylainino)-5- F NN 7. 06 (d d, J = 8.4, 7.3 311 (trifluoroinethyl)py 0 Hz1H)4.6-.3 riidin-2- 11 F (m 1 H), 3.67 - 3.59 0.206 ylamino)phenyl)(m H (m, 4H), 3.57 - 3.51 orpholino)methan (m, 2H), 3.29 - 3.23 one (m, 2H), 2.95 - 2.86 (d, J= 4.4 Hz, 3H), 1.35 - 1.24 (d, J= 6.1 Hz, 6H). 1 H NMR (400 MHz, DMSO) 6 9.20 (4-(4-(ethylamino)- 9.11 (s, 1H), 8.19 5- 0- F H 0 8.11 (s, 1 H), 8.07 7.98 (d, J = 8.9 Hz, (trifluoromethyl)py F N N 7. H), 7.45 7.38 (in, 312 rimidin-2-ylamino)- N2H), 7.22 -7.12 (t, J 0.028 3-H F - 5.6 Hz, 1 H), 3.66 (trifluoromethoxy) F O 3.56 (H, 4H), 3.59 phenyl)(morpholin F 3.41 (m, 4H), 3.42 o)methanone 3.35 (m, 2H), 1.14 1.02 (t, J= 7.0 Hz, 3H).

139 Ex. Name Structure 'H NMR Ki 1 H NMR (400 MHz, DMSO) o 9.20 (2-fluoro-3- F HN O 9.08 (s, 1H), 8.20 isopropoxy-4-(4- F 8.14 (s, 1H), 8.13 (methylamino)-5- F N N 8.06 (d, J= 8.9 Hz, 313 (trifluoromethyl)py N N O 1H), 7.46 - 7.38 (m, rimidin-2- H F 2H), 7.23 - 7.15 (m, ylamino)phenyl)(m F.r 1 H), 3.68 - 3.57 (m, orpholino)methan F 4H), 3.57 - 3.37 (m, one 4H), 2.89 - 2.82 (d, J = 4.4 Hz, 3H). Table 6 Example 11: 2-|2-Methoxy-4-(morpholine-4-carbonyl)-phenylaminol-4-methylamino pyrimidine-5-carbonitrile Zn(CN) 2 HN O Pd 2 (dba) 3 HN 0 DPPF Br NDMFA'. H 0 H 5 TA mixture of (4-(5-bromo-4-(methylamino)pyrimidin-2-ylamino)-3 methoxyphenyl)(morpholino)methanone (80 mg, 0.19 mmol), zinc cyanide (50 mg, 0.42 mmol), tris(dibenzylideneacetone)dipalladium (9 mg, 0.09 mmol), DPPF (11 mg, 0.02 mmol) in DMF (3 mL) was stirred at 105 oC in a pressure tube for 18 hours. The reaction mixture was filtered and concentrated. The crude product was purified by reverse phase HPLC to give the title compound 10 (70 mg, 82%). Additional compounds made using the above procedure are shown in Table 7 below. Ex. Name Structure 'H NMR Ki 1H NMR (400 MHz, 2-(2-methoxy-4- DMSO) 6 8.34 (s, (morpholine-4- HN O1H), 8.33 (s, 1H), carbonyl)phenyla N 8.18 (d, J= 8.2, 1H), 314 mino)-4- pN / N 7.81-7.70 (in, 1H), 0.002 (methylamino)pyri NN 7.08 (d,J= 1.5, 1H), 4 midine-5- H 7.01 (in, 1H), 3.88 carbonitrile 0 (s, 3H), 3.60 (s, 4H), 3.51 (s, 4H), 2.88 (d, J= 4.5, 3H) 140 Ex. Name Structure 'H NMR Ki 4-Methoxy-2-[2- 1 H NMR (400 MHz, methoxy-4- 0 DMSO): 6 9.27 (s, Nn 1H), 8.64 (s, 1H), 315 cabo lne-4 N N 7.85 (d, J= 7.9, 1H), 0.138 315 heanyl)- N N o 7.11 (s, 1H), 7.02 (d, pyrimidine-5- H J = 7.9, 1H), 3.98 (s, carbonitrile 0N 3H), 3.85 (s, 3H), 3.56 m, 8H). H NMR (400 MHz, 4-Ethylamino-2- DMSO) 6 8.39 (s, [5-fluoro-2- 1H), 8.32 (s, 1H), methoxy-4- NH F 0 8.17 (d, J= 12.0 Hz, 316 (morpholine-4- NN 1H), 7.96-7.90 (, 0.006 31Iaboy) I ~ H), 7.04 (d, J1=6.2 5 henylino]- N N O z, 1H), 3.88 (s, pyrimdine-5- 0 H), 3.48 - 3.38 (m, carbonitrile 3H), 1.17 (t, J= 7.1 Hz, 4H). 1H NMR (400 MHz, 2-[5-Fluoro-2- DMSO) 6 8.39 (s, methoxy-4- NH F 0 1H), 8.31 (s, 1H), (morpholine-4- N 8.22 (d, J = 11.9 Hz, 3 carbonyl)- N N" 1H), 7.88 (d, J = 3.8 0.011 317 phenylamino]-4- N N "'C: Io Hz, 1H), 7.04 (d, J= 2 methylamino- H 6.2 Hz, 1H), 3.88 (s, pyrimidine-5- 4H), 3.69 - 3.50 (m, carbonitrile 8H), 2.91 (d, J = 4.5 Hz, 4H). 'H NMR (400 MHz, DMSO) 6 8.40 (s, 1H), 8.32 (s, 1H), 2-[4-((2R,6S)-2,6- 8.23 (d, J= 12.0 Hz, Dimethyl- 1H), 7.89 (s, 1H), morpholine-4- N H F 0 7.03 (d, J= 6.2 Hz, caron-- N N~ NH), 4.40 (d, J= 318 carbony)-5- 13.1 Hz, 1H), 3.88 0.036 phenylamino]-4- H N (s, 3H), 3.52 (s, 2H), 8 methylamino- / 3.40 - 3.33 (m, J= pyrimidine-5- 10.8 Hz, 1H), 2.92 carbonitrile (d, J= 3.9 Hz, 3H), 2.81 (t, J= 11.8 Hz, 1H), 2.46 (d, J= 12.1 Hz, 1H), 1.20 0.95 (m, 6H). 2-[4-((2R,6S)-2,6- KH NMR (400 MHz, Dimethyl- NH F 0 DMSO) 6 8.40 (s, 319 morpholine-4- N N 1H), 8.33 (s, 1H), 0.019 carbonyl)-5- 0 8.17 (d, J= 12.0 Hz, 4 fluoro-2-methoxy- N N IH), 7.98 - 7.90 (m, phenylamino]-4- H o 1H), 7.03 (d, J= 6.2 141 Ex. Name Structure 'H NMR Ki ethylamino- Hz, 1H), 4.40 (d, J= pyrimidine-5- 12.9 Hz, 1H), 3.88 carbonitrile (s, 3H), 3.60 - 3.48 (m, 2H), 3.48 - 3.39 (m, 2H), 3.39 - 3.34 (m, 1H), 2.81 (t, J= 11.9 Hz, 1H), 2.49 2.42 (m, J = 12.0 Hz, 1H), 1.21 - 0.97 (m, 9H). H NMR (400 MHz, DMSO) 6 8.39 (s, 4-(5-Cyano-4- N NH F 0 1H), 8.30 (s, 1H), methylamino- N H,83(sIH) pyrimidin-2- N-- 8.19 (d, J= 11.9 Hz, 320 ylamino)-2-fluoro 1H), 7.90 - 7.83 (in, 0.062 N N 1H), 7.01 (d, J= 6.2 5 5-methoxy-N,N- H Hz, 1H), 3.87 (s, dimethyl- 4H), 2.99 (s, 3H), benzamide 2.91 (d, J= 4.5 Hz, 3H), 2.89 (s, 3H). Table 7 The corresponding pharmaceutically acceptable salts with acids can be obtained by standard methods known to the person skilled in the art, e.g. by dissolving the compound of formula I in a suitable solvent such as e.g. dioxan or THF and adding an appropriate amount of the 5 corresponding acid. The products can usually be isolated by filtration or by chromatography. The conversion of a compound of formula I into a pharmaceutically acceptable salt with a base can be carried out by treatment of such a compound with such a base. One possible method to form such a salt is e.g. by addition of 1/n equivalents of a basic salt such as e.g. M(OH), wherein M = metal or ammonium cation and n = number of hydroxide anions, to a solution of the compound 10 in a suitable solvent (e.g. ethanol, ethanol-water mixture, tetrahydrofuran-water mixture) and to remove the solvent by evaporation or lyophilisation. Particular salts are hydrochloride, formate and trifluoroacetate. Specific is hydrochloride. Insofar as their preparation is not described in the examples, the compounds of formula I as well as all intermediate products can be prepared according to analogous methods or according 15 to the methods set forth herein. Starting materials are commercially available, known in the art or can be prepared by methods known in the art or in analogy thereto. It will be appreciated that the compounds of general formula I in this invention may be derivatised at functional groups to provide derivatives which are capable of conversion back to the parent compound in vivo. 20 PHARMACOLOGICAL TESTS 142 The compounds of formula I and their pharmaceutically acceptable salts possess valuable pharmacological properties. It has been found that the compounds of the present invention are associated with modulation of LRRK2 activity. The compounds were investigated in accordance with the test given hereinafter. 5 Example 12 In Vitro LRRK2 LabChip Assay This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In a polypropylene plate, LRRK2, fluorescently-labeled peptide substrate, ATP and test compound were incubated together. Using a LabChip 3000 (Caliper Life Sciences), after the reaction the substrate was separated by 10 capillary electrophoresis into two populations: phosphorylated and unphosphorylated. The relative amounts of each were quantitated by fluorescence intensity. LRRK2 Ki was determined according to the equation: Y=VO*(1-((x+Ki*(1+S/Km)+Et)/(2*Et)-(((x+Ki*(1+S/Km)+Et)^2 (4*Et*x))^0.5)/(2*Et))). 15 Ki values in Table 4 and elsewhere herein are shown in pM. Assay conditions and materials used were as follows: Final Assay Conditions: LRRK2 G2019S in 5 mM MgCl2: 5.2 nM (Invitrogen lot # 567054A) LRRK2 G2019S in 1 mM MnCl2: 11 nM (Invitrogen lot # 567054A) 20 LRRK2 Wild type in 5 mM MgCl2: 15 nM (Invitrogen lot # 500607F) LRRK2 12020T in 5 mM MgCl2: 25 nM (Invitrogen lot # 43594) Substrate: 1 gM ATP: 130 gM Kinase reaction time: 2 hours 25 Temperature: ambient Total volume: 20 pl ATPapp Kms: G2019S in 5 mM MgCl2: 130 pM 143 G2019S in 1 mM MnCl2: 1 tM Wild type in 5 mM MgCl2: 80 pM 12020T in 5 mM MgCl2: 14 pM Materials: 5 Solid Support: Black 50 gL volume polypropylene 384 well plate (MatriCal cat # MP101-1-PP) Kinase: LRRK2 G2019S (Invitrogen cat # PV4882). LRRK2 Wild type (Invitrogen cat # PV4874). Substrate: 5FAM-GAGRLGRDKYKTLRQIRQ-CONH2 10 Non-binding plate: 384 well clear V-bottom polypropylene plates (Greiner cat # 781280). ATP: 10 mM ATP (Cell Signaling cat # 9804). Triton X-100: Triton X-100. Brij-35: Brij-35 (Pierce cat # 20150). 15 Coating Reagent #3: Coating Reagent #3 (Caliper). DMSO: DMSO (Sigma cat # 34869-100ML). Complete Reaction Buffer: H20/25 mM Tris, pH 8.0/5 mM MgCl2/2 mM DTT/0.01% Triton X-100. Stop Solution: H20/100 mM HEPES, pH 7.2/0.015% Brij-35/0.2% Coating Reagent 20 #3/20 mM EDTA. Separation Buffer: H20/100 mM HEPES, pH 7.2/0.015% Brij-35/0.1% Coating Reagent #3/1:200 Coating Reagent #8/10 mM EDTA/5% DMSO. Compound Plate Preparation: For serial dilutions, 34.6 pl DMSO was added to columns 3-24. For the assay controls, 25 37.5 pl DMSO was added to columns 1 and 2 of rows A and P. a,d and 50 pl 25 pM G-028831 (Staurosporine) was added to columns 1 and 2, row B. For the samples: to start at 100 gM, 37.5 gl DMSO was to columns 1 and 2, then 12.5 gl 10 mM compound; to start at 10 gM, 78 pl DMSO was added to columns 1 & 2, then 2 p1 10 mM compound; and to start at 1 pM, 25 pM 144 compound (2 tl 10 mM cmpd + 798 pl DMSO) was added to empty columns 1 and 2. A Precision instrument was used to perform 1:3.16 serial dilutions ("PLKBM-serialhalflog"). ATP Preparation: ATP was diluted to 282.1 pM in Complete Kinase Buffer (final concentration was 130 5 pM). Total and Blank Preparation: In Complete Reaction Buffer, substrate was diluted to 4 pM. Equal volumes of Complete Reaction Buffer and 4 jiM substrate were combined to obtain the blank. Equal volumes of Complete Reaction Buffer and 4 pM substrate were combined and to the combined solution was 10 added 2X final LRRK2 concentration. Assay Procedure: To a 50 ptl polypropylene plate, 5 pl/well buffer/substrate was added by hand to Blank wells. A Biomek FX was used to start the kinase reaction ("PLK SAR 23 ATP"). The following were added to the appropriate wells: 15 2 pl compound + 23 pl ATP; 5 pl/well compound/ATP in Assay Plate; 5 pl/well kinase/substrate in Assay Plate; The plate was incubated for 2 hours in the dark. Biomek FX was used to stop the kinase reaction ("PLK Stop"), and 10 pl/well Stop solution was added to the Assay Plate. Results were 20 read on the LabChip 3000. Lab Chip 3000 Protocol: The LabChip 3000 was run using the job "LRRK2 IC50" with the following job settings: Pressure: -1.4 psi Downstream voltage: -500 V 25 Upstream voltage: -2350 V Post sample buffer sip time: 75 seconds Post dye buffer sip time: 75 seconds Final delay time: 200 seconds 145 Example 13 In Vitro LRRK2 Lanthascreen binding Assay This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 384 well proxiplates F black, shallow well plates LRRK2, Eu-anti-GST-antibody, Alexa Fluor@ Kinase tracer 236 and test 5 compound were incubated together. Binding of the Alexa Fluor@ "tracer" to a kinase was detected by addition of a Eu labeled anti-GST antibody. Binding of the tracer and antibody to a kinase results in a high degree of FRET, whereas displacement of the tracer with a kinase inhibitor results in a loss of FRET. Assay conditions and materials used were as follows: 10 Final Assay Conditions: GST-LRRK2 G2019S 10 nM Eu-anti-GST-antibody 2nM Kinase tracer 236 8.5 nM Kinase reaction time: 1 hour 15 Temperature: ambient Total volume: 15 pl DMSO 1% Materials: 384 well proxiplates F black shallow well Perkin Elmer cat# 6008260 20 Kinase: LRRK2 G2019S Invitrogen cat # PV4882(LOT 567054A). Eu-labeled anti-GST antibody Invitrogen cat # PV5594 Alexa Fluor@ Kinase tracer 236 Invitrogen cat #PV5592 TRIS- HCl Sigma cat # T3253 EGTA Sigma cat # E3889 25 Brij-35: Sigma cat # B4184( 30% w/v) DMSO: Sigma cat # D8418 146 MgCl2 Sigma cat # M9272 Reaction Buffer: H20/50 mM Tris, pH 7.4/10mM MgCl2/1 mM EGTA/0.01% Brij 35. Compound Plate Preparation: Serially dilute test compounds (10mM stock) 1:3.16 (20ul + 43.2ul ) in 100% DMSO. 5 12pt curve. Dilute each concentration 1:33.3 (3ul +97u[) in reaction buffer. Stamp 5ul to assay plate. Final top test concentration 1OuM. Total and Blank Preparation: In Reaction Buffer,5ul of DMSO( 3%) was added to total and blank wells and 5ul of Eu labeled anti-GST antibody(6nM) was added to blank wells. 10 Assay Procedure: Add 5ul LRRK2(3OnM)/ Eu-labeled anti-GST antibody (6nM) mix to compound and total wells. Add 5ul kinase tracer (25.5nM) to all wells. Incubate plates at room temperature for 1 hour on a plate shaker (gentle shaking). Read on Perkin Elmer EnVision reader HTRF protocol. Data Handling: 15 Calculate ratio: (665/620)* 10000. Substract mean background values from all data points. Calculate % of control for each test value. Plot % of control vs Compound concentration. Calculate Ki Value (xlfit curve fitting- Morrison equation). Results expressed as a Ki in pM. The equation for Ki: Y=V0*(1 ((x+Ki*(1+S/Km)+Et)/(2*Et)-(((x+Ki*(1 +S/Km)+Et)A2-(4*Et*x))AO .5)/(2*Et))) 20 Where Et = 4nM kd (Tracer) = 8.5nM Tracer concentration (S) = 8.5nM. Example 14 Parkinson's disease animal model Parkinson's disease can be replicated in mice and in primates by administration of 1 25 methyl-4-phenyul tetrahydropyridine (MPTP), a selective nigrostriatal dopaminergic neurotoxin that produces a loss of striatal dopamine (DA) nerve terminal markers. Compounds of the invention may be evaluated for effectiveness in treatment of Parkinson's disease using MPTP induced neurodegeneration following generally the protocol described by Saporito et al., J. Pharmacology (1999) Vol. 288, pp. 421-427.

147 Briefly, MPTP is dissolved in PBS at concentrations of 2-4 mg/ml, and mice (male C57 weighing 20-25 g) are given a subcutaneous injection of 20 to 40 mg/kg. Compounds of the invention are solubilized with polyethylene glycol hydroxystearate and dissolved in PBS. Mice are administered 10 ml/kg of compound solution by subcutaneous injection 4 to 6 h before 5 MPTP administration, and then daily for 7 days. On the day of the last injection, mice are sacrificed and the midbrain blocked and postfixed in paraformaldehyde. Striata are dissected free, weighed, and stored at -70'C. The striata thus collected are evaluated for content of dopamine and its metabolites dihydroxyphenylacetic acid and homovanillic acid, by HPLC with electrochemical detection as 10 described by Sonsalla et al., J.Pharmacol. Exp. Ther. (1987) Vol. 242, pp. 850-857. The striata may also be evaluated using the tyrosine hydroxylase assay of Okunu et al., Anal Biochem (1987) Vol. 129, pp. 405-411 by measuring 14CO2 evolution associated with tyrosine hydroxylase mediated conversion of labeled tyrosine to L-dopa. The striata may further be evaluated using the Monoamine oxidase-B assay as described by White et al., Life Sci. (1984), Vol. 35, pp. 827 15 833, and by monitoring dopamine uptake as described by Saporito et al.,(1992) Vol. 260, pp. 1400-1409. While the present invention has been described with reference to the specific embodiments thereof, it should be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the true spirit and scope 20 of the invention. In addition, many modifications may be made to adapt a particular situation, material, composition of matter, process, process step or steps, to the objective spirit and scope of the present invention. All such modifications are intended to be within the scope of the claims appended hereto. PHARMACEUTICAL COMPOSITIONS 25 The compounds of formula I and the pharmaceutically acceptable salts can be used as therapeutically active substances, e.g. in the form of pharmaceutical preparations. The pharmaceutical preparations can be administered orally, e.g. in the form of tablets, coated tablets, drag6es, hard and soft gelatin capsules, solutions, emulsions or suspensions. The administration can, however, also be effected rectally, e.g. in the form of suppositories, or parenterally, e.g. in 30 the form of injection solutions. The compounds of formula I and the pharmaceutically acceptable salts thereof can be processed with pharmaceutically inert, inorganic or organic carriers for the production of pharmaceutical preparations. Lactose, corn starch or derivatives thereof, talc, stearic acids or its salts and the like can be used, for example, as such carriers for tablets, coated tablets, drag6es 35 and hard gelatin capsules. Suitable carriers for soft gelatin capsules are, for example, vegetable oils, waxes, fats, semi-solid and liquid polyols and the like. Depending on the nature of the active substance no carriers are however usually required in the case of soft gelatin capsules.

148 Suitable carriers for the production of solutions and syrups are, for example, water, polyols, glycerol, vegetable oil and the like. Suitable carriers for suppositories are, for example, natural or hardened oils, waxes, fats, semi-liquid or liquid polyols and the like. The pharmaceutical preparations can, moreover, contain pharmaceutically acceptable 5 auxiliary substances such as preservatives, solubilizers, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances. Medicaments containing a compound of formula I or a pharmaceutically acceptable salt thereof and a therapeutically inert carrier are also provided by the present invention, as is a 10 process for their production, which comprises bringing one or more compounds of formula I and/or pharmaceutically acceptable salts thereof and, if desired, one or more other therapeutically valuable substances into a galenical administration form together with one or more therapeutically inert carriers. The dosage can vary within wide limits and will, of course, have to be adjusted to the 15 individual requirements in each particular case. In the case of oral administration the dosage for adults can vary from about 0.01 mg to about 1000 mg per day of a compound of general formula I or of the corresponding amount of a pharmaceutically acceptable salt thereof. The daily dosage may be administered as single dose or in divided doses and, in addition, the upper limit can also be exceeded when this is found to be indicated. 20 The following examples illustrate the present invention without limiting it, but serve merely as representative thereof. The pharmaceutical preparations conveniently contain about 1 500 mg, preferably 1-100 mg, of a compound of formula I. Examples of compositions according to the invention are: Example A 25 Tablets of the following composition are manufactured in the usual manner: ingredient _725__ mg/tablet 525 100 500 Compound of formula I 5 25 100 500 Lactose Anhydrous DTG 125 105 30 150 Sta-Rx 1500 6 6 6 60 Microcrystalline Cellulose 30 30 30 450 Magnesium Stearate 1 1 1 1 Total 167 167 167 831 Table 8: possible tablet composition 149 Manufacturing Procedure 1. Mix ingredients 1, 2, 3 and 4 and granulate with purified water. 2. Dry the granules at 5 0 'C. 3. Pass the granules through suitable milling equipment. 5 4. Add ingredient 5 and mix for three minutes; compress on a suitable press. Example B-I Capsules of the following composition are manufactured: ingredient mg/capsule 525 I100 500 Compound of formula I 5 25 100 500 Hydrous Lactose 159 123 148 Corn Starch 25 35 40 70 Talk 10 15 10 25 Magnesium Stearate 1 2 2 5 Total 200 200 300 600 Table 9: possible capsule ingredient composition Manufacturing Procedure 10 1. Mix ingredients 1, 2 and 3 in a suitable mixer for 30 minutes. 2. Add ingredients 4 and 5 and mix for 3 minutes. 3. Fill into a suitable capsule. The compound of formula I, lactose and corn starch are firstly mixed in a mixer and then in a comminuting machine. The mixture is returned to the mixer; the talc is added thereto and 15 mixed thoroughly. The mixture is filled by machine into suitable capsules, e.g. hard gelatin capsules. Example B-2 Soft Gelatin Capsules of the following composition are manufactured: ingredient mg/capsule Compound of formula I 5 Yellow wax 8 Hydrogenated Soya bean oil 8 Partially hydrogenated plant oils 34 Soya bean oil 110 150 Total 165 Table 10: possible soft gelatin capsule ingredient composition ingredient mg/capsule Gelatin 75 Glycerol 85 % 32 Karion 83 8 (dry matter) Titan dioxide 0.4 Iron oxide yellow 1.1 Total 116.5 Table 11: possible soft gelatin capsule composition Manufacturing Procedure The compound of formula I is dissolved in a warm melting of the other ingredients and the 5 mixture is filled into soft gelatin capsules of appropriate size. The filled soft gelatin capsules are treated according to the usual procedures. Example C Suppositories of the following composition are manufactured: ingredient mg/supp. Compound of formula I 15 Suppository mass 1285 Total 1300 Table 12: possible suppository composition 10 Manufacturing Procedure The suppository mass is melted in a glass or steel vessel, mixed thoroughly and cooled to 45'C. Thereupon, the finely powdered compound of formula I is added thereto and stirred until it has dispersed completely. The mixture is poured into suppository moulds of suitable size, left to cool; the suppositories are then removed from the moulds and packed individually in wax paper 15 or metal foil. Example D Injection solutions of the following composition are manufactured: ingredient mg/injection solution. Compound of formula I 3 151 Polyethylene Glycol 400 150 acetic acid g.s. ad pH 5.0 water for injection solutions ad 1.0 ml Table 13: possible injection solution composition Manufacturing Procedure The compound of formula I is dissolved in a mixture of Polyethylene Glycol 400 and water for injection (part). The pH is adjusted to 5.0 by acetic acid. The volume is adjusted to 1.0 ml by 5 addition of the residual amount of water. The solution is filtered, filled into vials using an appropriate overage and sterilized. Example E Sachets of the following composition are manufactured: ingredient mg/sachet Compound of formula I 50 Lactose, fine powder 1015 Microcrystalline cellulose (AVICEL PH 102) 1400 Sodium carboxymethyl cellulose 14 Polyvinylpyrrolidon K 30 10 Magnesium stearate 10 Flavoring additives 1 Total 2500 Table 14: possible sachet composition 10 Manufacturing Procedure The compound of formula I is mixed with lactose, microcrystalline cellulose and sodium carboxymethyl cellulose and granulated with a mixture of polyvinylpyrrolidone in water. The granulate is mixed with magnesium stearate and the flavoring additives and filled into sachets.

Claims

1. A compound of formula I: R5 R N X R6e R2 ) N N N N 7m H (R )m R 3 or pharmaceutically acceptable salts thereof, 5 wherein: m is from 0 to 3; X is: -NRa-; -0-; or -S(O)r- wherein r is from 0 to 2 and Ra is hydrogen or C1_ 6 alkyl; RI is: C1- 6 alkyl; C 2 - 6 alkenyl; C 2 - 6 alkynyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-C1-6alkyl; hydroxy C 2 - 6 alkenyl; amino-Ci- 6 alkyl; Ci- 6 alkylsulfonyl-CI_ 6 alkyl; C 3 _ 6 cycloalkyl optionally substituted 10 with CI- 6 alkyl; C 3 - 6 cycloalkyl-Ci- 6 alkyl wherein the C 3 - 6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; tetrahydropuranyl; tetrahydropuranyl-C1-alkyl,oxetanyl; or oxetan-Ci- 6 alkyl; or R' and Ra together with the atoms to which they are attached may form a three to six membered ring that may optionally include an additional heteroatom selected from 0, N and S, 15 and which is substituted with oxo, halo or C1_ 6 alkyl; R is: halo; C1_6alkoxy; cyano; C 2 _ 6 alkynyl; C 2 _ 6 alkenyl; halo-C1_ 6 alkyl; halo-CI 6 alkoxy; C 3 - 6 cycloalkyl wherein the C 3 - 6 cycloalkyl portion is optionally substituted with CI- 6 alkyl; C 3 _ 6 cycloatkyl-CI- 6 alkyl wherein the C 3 _ 6 cycloalkyl portion is optionally substituted with CI- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; acetyl; oxetanyl; or oxetan-Ci- 6 alkyl; 20 R3 is: -OR 4 ; halo; cyano; CI 6 alkyl; halo-Ci- 6 alkyl; C 3 - 6 cycloalkyl optionally substituted with Ci_ 6 alkyl; C 3 _ 6 cycloalkyl-C1_ 6 alkyl wherein the C3_ 6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-CI_ 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; R 4 is: hydrogen, Ci- 6 alkyl; halo-Ci- 6 alkyl; C1- 6 alkoxy-Ci-salkyl; C 3 _ 6 cycloalkyl optionally 25 substituted with Ci- 6 alkyl or halo; C 3 _ 6 cycloalkyl-CI_ 6 alkyl wherein the C 3 _ 6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl or halo; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; oxetanyl; or oxetan-Ci- 6 alkyl; 153 R 5 is: hydrogen; or CI 6 alkyl; n is 0 or 1; R6 is: hydrogen; C1- 6 alkyl; C1- 6 alkoxy-CI_ 6 alkyl; hydroxy-C1- 6 alkyl; amino-C1- 6 alkyl; C 3 _ 6 cycloalkyl; C 3 - 6 cycloalkyl-C1- 6 alkyl; heterocyclyl; or heterocyclyl-CI_ 6 alkyl; wherein the C 3 _ 5 6 cycloalkyl, C 3 _ 6 cycloalkyl-CI- 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be optionally substituted with one, two, three or four groups groups independently selected from: C1- 6 alkyl; halo-CI_ 6 alkyl; CI_ 6 alkoxy; halo-C1- 6 alkoxy; hydroxy; hydroxy-CI- 6 alkyl; halo; nitrile; C1- 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl; C 3 _ 6 cycloalkyl; C 3 - 6 cycloalkyl-CI- 6 alkyl; C 3 _ 6 cycloalkyl carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are 10 attached may form a five or six-membered ring; or R 5 and R6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that optionally includes an additional heteroatom selected from 0, N and S(O), and which is optionally substituted with one, two, three or four groups independently selected from: C1_ 6 alkyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy; halo-C1_ 6 alkoxy; hydroxy; hydroxy-C1_ 6 alkyl; 15 halo, nitrile; C1_ 6 alkyl-carbonyl; CI_ 6 alkyl-sulfonyl; C 3 _ 6 cycloalkyl; C 3 _ 6 cycloalkyl-CI_ 6 alkyl; C 3 _ 6 cycloalkyl-carbonyl; amino; C1- 6 alkyl-heterocyclyl, CI_ 6 alkoxy-C1- 6 alkyl or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six membered ring; and R7 is: halo; C1_ 6 alkyl; Ci- 6 alkoxy; halo-C1_ 6 alkyl; or halo-C1_ 6 alkoxy. 20

2. A compound of formula I according to claim 2: R N O X R6e R2 Nn N N 7m H (R )m R 3 or pharmaceutically acceptable salts thereof, wherein: m is from 0 to 3; 25 X is: -NRa-; -0-; or -S(O).- wherein n is from 0 to 2 and Ra is hydrogen or C1_ 6 alkyl; RI is: C1_ 6 alkyl; C 2 _ 6 alkenyl; C 2 - 6 alkynyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy-C1_ 6 alkyl; hydroxy C 2 - 6 alkenyl; amino-C1- 6 alkyl; C1- 6 alkylsulfonyl-CI_ 6 alkyl; C 3 _ 6 cycloalkyl optionally substituted 154 with Ci_ 6 alkyl; C 3 _ 6 cycloalkyl-C1_ 6 alkyl wherein the C3_ 6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; or R 1 and Ra together with the atoms to which they are attached may form a three to six 5 membered ring that may optionally include an additional heteroatom selected from 0, N and S, and which is substituted with oxo, halo or CI 6 alkyl; R2 is: halo; Ci-salkoxy; cyano; C 2 - 6 alkynyl; C 2 - 6 alkenyl; halo-Ci- 6 alkyl; halo-CI- 6 alkoxy; C 3 - 6 cycloalkyl wherein the C 3 - 6 cycloalkyl portion is optionally substituted with CI- 6 alkyl; C 3 _ 6 cycloalkyl-CI- 6 alkyl wherein the C 3 _ 6 cycloalkyl portion is optionally substituted with Ci- 6 alkyl; 10 tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; acetyl; oxetanyl; or oxetan-C1_ 6 alkyl; R3 is: -OR 4 ; halo; cyano; C1_ 6 alkyl; halo-C1_ 6 alkyl; C 3 _ 6 cycloalkyl optionally substituted with CI- 6 alkyl; C 3 _ 6 cycloalkyl-Ci- 6 alkyl wherein the C3- 6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-CI_ 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; 15 R 4 is: C1_ 6 alkyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy-C1_ 6 alkyl; C 3 _ 6 cycloalkyl optionally substituted with Ci- 6 alkyl or halo; C 3 _ 6 cycloalkyl-Ci- 6 alkyl wherein the C 3 _ 6 cycloalkyl portion is optionally substituted with CI 6 alkyl or halo; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; oxetanyl; or oxetan-Ci- 6 alkyl; R5 is: hydrogen; or CI 6 alkyl; 20 n is 0 or 1; R6 is: hydrogen; C1_ 6 alkyl; C1_ 6 alkoxy-C1_ 6 alkyl; hydroxy-C1_ 6 alkyl; amino-Ci- 6 alkyl; C 3 _ 6cycloalkyl; C 3 - 6 cycloalkyl-C1- 6 alkyl; heterocyclyl; or heterocyclyl-CI_ 6 alkyl; wherein the C 3 _ 6 cycloalkyl, C 3 - 6 cycloalkyl-CI- 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be optionally substituted with one, two, three or four groups groups independently selected from: 25 C1- 6 alkyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy; halo-C1_ 6 alkoxy; hydroxy; hydroxy-C- 6 atkyl; halo; nitrile; C1- 6 alkyl-carbonyl; Ci- 6 alkyl-sulfonyl; C 3 _ 6 cycloalkyl; C3- 6 cycloalkyl-Ci- 6 alkyl; C 3 _ 6 cycloalkyl carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; or R5 and R6 together with the nitrogen atom to which they are attached form a three- to 30 seven-membered ring that optionally includes an additional heteroatom selected from 0, N and S(O), and which is optionally substituted with one, two, three or four groups independently selected from: Ci- 6 alkyl; halo-CI_ 6 alkyl; CI_ 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI 6 alkyl; halo, nitrile; C1_ 6 alkyl-carbonyl; CI_ 6 alkyl-sulfonyl; C 3 _ 6 cycloalkyl; C3_ 6 cycloalkyl-C1_ 6 alkyl; C 3 6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to 35 which they are attached may form a five or six-membered ring; and 155 R7 is: halo; C1_ 6 alkyl; Ci- 6 alkoxy; halo-C1_ 6 alkyl; or halo-C1_ 6 alkoxy.

3. The compound of any one of claims 1-2, wherein said compound is of formula II: 1 RR R N NN N N H R 3 or a pharmaceutically acceptable salt thereof, 5 wherein: m is from 0 to 3; X is: -NRa-; -0-; or -S(O),- wherein n is from 0 to 2 and Ra is hydrogen or C1_ 6 alkyl; RI is: Ci- 6 alkyl; C 2 - 6 alkenyl; C 2 - 6 alkynyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-Ci- 6 alkyl; hydroxy C 2 6 alkenyl; amino-C1_ 6 alkyl; C1_ 6 alkylsulfonyl-C1_ 6 alkyl; C 3 6 cycloalkyl optionally substituted 10 with Ci_ 6 alkyl; C 3 - 6 cycloalkyl-C1_ 6 alkyl wherein the C3- 6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-CI_ 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; R2 is: halo; CI6alkoxy; cyano; C 2 - 6 alkynyl; C 2 - 6 alkenyl; halo-Ci- 6 alkyl; halo-CI- 6 alkoxy; C 3 _ 6 cycloalkyl wherein the C 3 _ 6 cycloalkyl portion is optionally substituted with C1_ 6 alkyl; C 3 _ 15 6 cycloalkyl-Ci- 6 alkyl wherein the C 3 _ 6 cycloalkyl portion is optionally substituted with Ci- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-Ci- 6 alkyl; oxetanyl; or oxetan-CI 6 alkyl; R3 is: -OR 4 ; halo; cyano; C3- 6 cycloalkyl optionally substituted with Ci- 6 alkyl; C 3 _ 6 cycloalkyl-C1- 6 alkyl wherein the C 3 _ 6 cycloalkyl portion is optionally substituted with CI 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-C1_ 6 alkyl; oxetanyl; or oxetan-C1_ 6 alkyl; 20 R4 is: Ci- 6 alkyl; halo-Ci- 6 alkyl; Ci- 6 alkoxy-CI 6 alkyl; C 3 - 6 cycloalkyl optionally substituted with CI- 6 alkyl; C 3 _ 6 cycloalkyl-Ci- 6 alkyl wherein the C3- 6 cycloalkyl portion is optionally substituted with C1- 6 alkyl; tetrahydrofuranyl; tetrahydrofuranyl-CI_ 6 alkyl; oxetanyl; or oxetan-C 1 _ 6 alkyl; R 5 is: hydrogen; or C1_ 6 alkyl; 25 R 6 is: hydrogen; C1_ 6 alkyl; C1_ 6 alkoxy-C1_ 6 alkyl; amino-Ci- 6 alkyl; C 3 _ 6 cycloalkyl; C 3 _ 6 cycloalkyl-CI- 6 alkyl; heterocyclyl; or heterocyclyl-Ci- 6 atkyl; wherein the C 3 _ 6 cycloalkyl, C 3 _ 6 cycloalkyl-CI- 6 alkyl, heterocyclyl and heterocyclyl-CI 6 alkyl each may be optionally substituted 156 with one, two or three groups independently selected from: C1_ 6 alkyl; halo-C1_ 6 alkyl; CI 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-CI_ 6 alkyl; halo; nitrile; C1- 6 alkyl-carbonyl; C1- 6 alkyl-sulfonyl; C 3 - 6 cycloalkyl; C 3 - 6 cycloalkyl-C1- 6 alkyl; C 3 - 6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six 5 membered ring; or R 5 and R 6 together with the nitrogen atom to which they are attached form a three- to seven-membered ring that optionally includes an additional heteroatom selected from 0, N and S(O), and which is optionally substituted with one, two or three groups independently selected from: C1_ 6 alkyl; halo-C1_ 6 alkyl; C1_ 6 alkoxy; halo-CI_ 6 alkoxy; hydroxy; hydroxy-Ci- 6 alkyl; halo, 10 nitrile; CI 6 alkyl-carbonyl; CI_ 6 alkyl-sulfonyl; C 3 - 6 cycloalkyl; C 3 _ 6 cycloalkyl-CI_ 6 alkyl; C 3 _ 6 cycloalkyl-carbonyl; amino; or heterocyclyl; or two of the groups together with the atoms to which they are attached may form a five or six-membered ring; and R7 is: halo; CI 6 alkyl; Ci- 6 alkoxy; halo-C1_ 6 alkyl; or halo-C1- 6 alkoxy.

4. The compound of claim 3 wherein m is 0 or 1. 15

5. The compound of claim 3 wherein X is -NRa-or -0-.

6. The compound of claim 3 wherein X is -NRa.

7. The compound of claim 3 wherein RI is C1- 6 alkyl.

8. The compound of claim 3 wherein R 2 is: halo; halo-CI 6 alkyl; or cyano.

9. The compound of claim 3 wherein R 2 is: chloro, trifluoromethyl or cyano. 20

10. The compound of claim 3 wherein R 3 is: halo; or -OR4.

11. The compound of claim 3 wherein R 3 is: halo; CI- 6 alkoxy; or halo-CI_ 6 alkoxy.

12. The compound of claim 3 wherein R 3 is: methoxy; chloro; or fluoro.

13. The compound of claim 3 wherein m is 1 and R7 is halo or methoxy.

14. The compound of claim 3 wherein R 5 and R6 together with the nitrogen atom to which 25 they are attached form a three- to six-membered ring that is optionally includes an additional heteroatom selected from 0, N and S, and which is optionally substituted with one, two or three groups independently selected from CI- 6 alkyl, halo-CI- 6 alkyl, C 1 _ 6 alkoxy, halo-CI_ 6 alkoxy, hydroxy, hydroxy- C1- 6 alkyl, halo, nitrile, CI_ 6 alkyl-carbonyl, C1_ 6 alkyl-sulfonyl, C 3 _ 6 cycloalkyl, C3_ 6 cycloalkyl-C1_ 6 alkyl, C 3 _ 6 cycloalkyl-carbonyl, 30 amino, or heterocyclyl, or two of the groups together with the atoms to which they are attached may form a five or six-membered ring. 157

15. The compound of claim 3 wherein R 5 and R 6 together with the nitrogen atom to which they are attached form a morpholinyl group that is optionally substituted once or twice with groups independently selected from CI6alkyl, halo-C1-6alkyl, CI-6alkoxy, halo-C 1 _ 6alkoxy, hydroxy, hydroxy-CI_6alkyl, halo, nitrile, C1_6alkyl-carbonyl, C1_6alkyl-sulfonyl, 5 C 3 _6cycloalkyl, C 3 _6cycloalkyl-C1_ 6 alkyl, C 3 _6cycloalkyl-carbonyl, amino, or heterocyclyl, or the two groups together with the atoms to which they are attached may form a five or six-membered ring.

16. The compound of claim 3 wherein said compound is of formula III X 2 R(R )m R RN N )P 4k C N N H R 10 wherein: p is from 0 to 2; 1011 12 11 12 Y is: -0-; -S(O)-; -NR U; or -CR"R - when p is 1 or 2; and Y is -CR R - when p is 0; R 8 and R 9 each independently is: hydrogen; C 1 _ 6 alkyl; halo-C 1 _ 6 alkyl; C 1 _ 6 alkoxy; halo C1-6alkoxy; hydroxy; hydroxy-C1-6alkyl; halo; nitrile; CI6alkyl-carbonyl; C1-6alkyl-sulfonyl; C 3 _ 15 6 cycloalkyl; C 3 - 6 cycloalkyl-C 1 _ 6 alkyl; C 3 - 6 cycloalkyl-carbonyl; amino; or heterocyclyl; or R' and R 9 together with the atoms to which they are attached form a five- or six membered ring; R 10 is: hydrogen; CI- 6 alkyl; hydroxy-C 1 _ 6 alkyl; halo-C 1 _ 6 alkyl; hydroxy-C 1 _ 6 alkyl; C 1 _ 6alkyl-carbonyl; CI-6alkyl-sulfonyl; C 3 -6cycloalkyl; C 3 -6cycloalkyl-CI-6alkyl; C 3 - 6 cycloalkyl 20 carbonyl; heterocyclyl; or heterocyclyl-C 1 - 6 alkyl; or one of R" and R 9 together with R 1 0 and the atoms to which they are attached form a five- or six-membered ring; R 11 is: hydrogen; C 1 - 6 alkyl; or halo; R is: hydrogen; C 1 _ 6 alkyl; halo-C1_ 6 alkyl; C 1 _ 6 alkoxy; halo-C 1 _ 6 alkoxy; hydroxy; 25 hydroxy-CI_6alkyl; halo; nitrile; CI6alkyl-carbonyl; CI6alkyl-sulfonyl; C 3 -6cycloalkyl; C 3 _ 6 cycloalkyl-C 1 - 6 alkyl; C 3 -6cycloalkyl-carbonyl; amino; heterocyclyl; or heterocyclyl-C 1 _ 6 alkyl; 158 or R 11 and R 12 together with the atom to which they are attached may form a 3- to six membered ring that optionally includes a heteroatom selected from 0, N and S; or one of R" and R 9 together with R 1 0 and the atoms to which they are attached form a five- or six-membered ring; 5 or one of R 8 and R 9 together with R 12 and the atoms to which they are attached form a five- or six-membered ring; and 1 2 m, n, X, R , R , R 3 and R 7 are as defined herein.

17. The compound of claim 3 wherein p is 1.

18. The compound of claim 3 wherein Y is -0-; -NR ; or -CR"R -. 10

19. The compound of claim 3 wherein Y is -0-.

20. A compound according to any of claims I to 19, selected from the group consisting of 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-ethyl)-2-methoxy benzamide, 15 5-Chloro-N-cyclopropyl-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino) benzamide, ((2S,6R)-2,6-dimethylmorpholino)(2-fluoro-5-methoxy-4-(4-(methylamino)-5 (trifluoromethyl)pyrimidin-2-ylamino)phenyl)methanone, (IS,4S)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-yl(2-fluoro-3-methoxy-4-(4-(methylamino)-5 20 (trifluoromethyl)pyrimidin-2-ylamino)phenyl)methanone, (IS,4S)-2-oxa-5-azabicyclo[2.2.1 ]heptan-5-yl(4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)-2-fluoro-3-methoxyphenyl)methanone, (2,6-Dimethyl-morpholin-4-yl)-[3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2 ylamino)-phenyl]-methanone, 25 (2-ethoxy-5-fluoro-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, (2-fluoro-3-isopropoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, (2-fluoro-3-isopropoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 30 ylamino)phenyl)(morpholino)methanone, (2-fluoro-5-methoxy-4-(4-(2-methoxyethoxy)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, (2-fluoro-5-methoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)phenyl)(3 methoxypyrrolidin- 1 -yl)methanone, 159 (3-methoxy-4-(5-methoxy-4-(methylamino)pyrimidin-2-ylamino)phenyl) (morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-3 methoxyphenyl)(morpholino)methanone, 5 (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-2-fluoro-3 isopropoxyphenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3 (trifluoromethoxy)phenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3 10 (trifluoromethoxy)phenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl-amino)-3 isopropoxyphenyl)(morpholino)methanone, (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3 isopropoxyphenyl)(morpholino)methanone, 15 (4-(4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-5 -fluoro-2 methoxypheny1)(morpholino)methanone, (4-(4-(mcthylamino)-5 -(trifluoromcthyl)pyrimidin-2-ylamino)-3 (trifluoromethoxy)phenyl)(morpholino)methanone, (4-(5 -bromo-4-methoxypyrimidin-2-ylamino)-3 -methoxyphenyl)(3-(trifluoromethyl)pyrrolidin 20 1 -yl)methanone, (4-(5 -chloro-4-(mcthylamino)pyrimidin-2-ylamino)-3 -methylphenyl)(morpholino)methanonc, (4-(5 -chloro-4-(methylamino)pyrimidin-2-ylamino)-3 -methylphenyl)(4-hydroxypiperidin- I1 yl)methanone, (4-(5 -chloro-4-(piperi din- I -yl)pyrimidin-2-ylamino)-3-methoxyphenyl)(morpholino)methanione, 25 (4-(5 -chloro-4-(pyrrolidin- 1 -yl)pyrimnidin-2-ylam-ino)-3 -methoxyphenyl)(morpholino)methanonc, (4-(5 -chloro-4-methoxypyrimidin-2-ylamino)-3 -methoxyphenyl)(pyrrolidin- 1 -yl)methanone, (4-(5 -cyclopropyl-4-methoxypyrimidin-2-ylamino)-3 -methoxyphenyl)(morpholino)methanone, (4- { 5 -Ch loro-4- [(tetrahydro-furan -')-ylmethyl)-amino]-pyrimi din -2-yl amino } -3-methoxy phenyl)-morpholin-4-yl-methanone, 30 (4- {5 -Chloro-4- [(tetrahydro-furan-3 -ylmethyl)-amino]-pyrimidin-2-ylamino } -3-methoxy phenyl)-morpholin-4-yl-methanone, (4-Dimethylamino-piperidin-I -yl)-[3-methoxy-4-(4-methyl amino-S -trifluoromethyl-pyrimidin 2-ylamino)-phenyl] -methanone, (4-tert-Butyl-piperidin- l-yl)- [4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy 35 phenyl]-methanone , (5-chloro-2-methoxy-4-(4-(methylamino)-5 -(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(perdeuteromorpholino)methanone, (5-chloro-2-methoxy-4-(4-(methylamino)-5 -(trifluoromethyl)pyrimidin-2-ylamino)phenyl)(3 methoxypyrrolidin- 1 -yl)methanone, 160 (5-chloro-4-(5 -chloro-4-(methylamino)pyrimidin-2-ylamino)-2 methoxypheny1)(morpholino)methanone, (5-fluoro-2-methoxy-4-(4-(methylamino)-5 -(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, 5 [2-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-5-methoxy-phenyl]-morpholin-4 yl-methanone, [2-Chloro-5 -methoxy-4-(4-methoxy-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [2-Chloro-5 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] 10 morpholin-4-yl-methanone, [2-Fluoro-3 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [2-Fluoro-5 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, 15 [2-Fluoro-5 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -((S)-2 methoxymethyl-pyrrolidin- 1 -yl)-methanone, [3-(2-Eluoro-ethoxy)-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phnyl] morpholin-4-yl-methanone, [3-Bromo-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl 20 methanone, [3-Bromo-4-(5 -chloro-4-mcthylamino-pyrimidin-2--ylamino)-phcnyl]-morpholin-4-yl-methanon, [3-Chloro-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl methanone, [3-Chloro-4-(5 -chloro-4-methoxy-pyrimi din-2-ylamino)-phenyl]-morpholin-4-yl-methanone, 25 [3-Chloro-4-(5 -chloro-4-mcthylamino-pyrimidin-2-ylamino)-phcnyl]-morpholin-4-yl-methanone, [3-Cyclobutoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin 4-yl-methanone, [3-Cyclobutylmethoxy-4-(4-met'ylamino-5-tri fluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, 30 [3-Cyclopropyl-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morphiolin 4-yl-methanone, [3-Cyclopropylmethoxy-4-(4-methyl amino-5 -trifluoromethyl-pyrimidin-2-yl amino)-phenyl] morpholin-4-yl-methanone, [3-Ethoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl 35 methanone, [3-Isopropoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4 yl-methanone, L3-Methoxy-4-(4-methoxy-5 -prop- I -ynyl-pyrimidin-2-ylamino)-phenyl] -moipholin-4-yl methanone, 161 [3-Methoxy-4-(4-methoxy-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl methanone, [3-Methoxy-4-(4-methylamino-5 -prop- I -ynyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl methanone, 5 [3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -morpholin-4-yl methanone, [3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -(8-oxa-3 -aza bicyclo [3.2.1I ]oct-3 -yl)-methanone, [3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -(2-oxa-5 -aza 10 bicyclo [2.2.1I ]hept-5 -yl)-methanone, [3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -pyrrolidin- l -yl methanone, [3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]- [4-(2,2,2 trifluoro-ethyl)-piperazin- 1 -yl]-methanone, 15 [3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -(4-methoxy piperidin- 1 -yl)-methanone, [3-Methoxy-4-(4-pyrrolidin- l -yl-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4 yl-methanone, [4-(4-Ethylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-phenyl] 20 morpholin-4-yl-methanone, [4-(4-Ethylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-phenyl] -((S)-2 methoxymethyl-pyrrolidin- 1 -yl)-methanone, [4-(5 -Bromo-4-ethoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -morpholin-4-yl-methanone, [4-(5 -Bromo-4-isopropoxy-pyrirnidin-2-ylamino)-3 -methoxy-phenyl ]-morpholin-4-yl 25 methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-2-chloro-5 -methoxy-phenyl] -morpholin-4-yl methanone, [4-(5 -Bromo-4-nieth oxy-pyrimi din -2-yl ami no)-2-fluoro-5 -methoxy-pheonyl ] -morpholin -4-yl methanone, 30 [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -cyclobutoxy-phenyl] -morpholin-4-yl methanone, [4-(5 -Bromo-4-methoxy-pyrirnidin-2-ylamino)-3 -cyclopropoxy-phenyl] -morpholin-4-yl methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -ethoxy-phenyl] -morpholin-4-yl-methanone, 35 [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -isopropoxy-phenyl] -morpholin-4-yl methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-((R)-2,2--di-deutero-3 methyl-morpholin-4-yl)-methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-((S)-2-,2-di-deutero-3 40 methyl-morpholin-4-yl)-methanone, 162 [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-morpholin-4-yl-azetidin 1 -yl)-methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4,4-difluoro-piperidin- 1-yl) methanone, 5 [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-ethyl-piperazin- 1-yl) methanone, [4-(5 -Bromo-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]- [4-(1 -hydroxy- 1-methyl ethyl)-piperidin- 1 -yl]-methanone, [4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, 10 [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Bromo-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]- [4-(1 -hydroxy- 1-methyl ethyl)-piperidin- 1 -yl]-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-trifluoromethyl 15 pyrrolidin- 1 -yl)-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-cyclobutyl-piperazin 1 -yl)-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-[4-(2,2,2-trifluoro ethyl)-piperazin- 1-yl] -methanone, 20 [4-(5 -Bromo-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-methoxy-piperidin- 1 yl)-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-((R)-3-hydroxy pyrrolidin- 1 -yl)-methanone, [4-(5 -Bromo-4-methyl amino-pyrimidin-2-ylamino)-3 -methoxy-phenyl ]-(4-oxetan-3 -yl 25 piperazin-1 -yl)-methanone, [4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-5-chloro-2-methoxy-phenyl]-morpholin-4 yl-methanone, [4-(5 -Chloro-4-cyclobutyl amino-pyrimidin-2-ylamino)-3 -methoxy-phenyl ]-morpholin-4-yl methanone, 30 [4-(5-Chloro-4-cyclohexylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-cyclopentyl amino-pyrimi din-2-yl amino)-3 -methoxy-phenyl] -morpholin-4-yl methanone, [4-(5-Chloro-4-ethoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, 35 [4-(5-Chloro-4-ethylamino-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Chloro-4-ethylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Chloro-4-isobutylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl 40 methanone, 163 [4-(5 -Chloro-4-isopropoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-isopropylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl methanone, 5 [4-(5 -Chloro-4-methoxy-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-phenyl] -morpholin-4-yl methanone, [4-(5 -Chloro-4-methoxy-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-phenyl] -morpholin-4 yl-methanone, 10 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -(2,2,2-trifluoro-ethoxy)-phenyl] morpholin-4-yl-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -(oxetan-3 -yloxy)-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclobutoxy-phenyl] -morpholin-4-yl 15 methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopentyloxy-phenyl] -(2-oxa-6-aza spiro [3.3 ]hept-6-yl)-mcthanonc, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopentyloxy-phenyl] -morpholin-4-yl methanone, 20 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopropoxy-phenyl]-morpholin-4-yl mcthanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -cyclopropyl-phenyl]-morpholin-4-yl methanone, [4-(5 -Chiloro-4-methyl amino-pyrimi din -2-ylamin o)-3 -di fluoromethoxy-phenyl ]-morpholi n-4-yl 25 methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -difluoromethoxy-phenyl]-(4-hydroxy pip eridin- 1 -yl)-methanone, [4-(5 -Cbloro-4-methyl amino-pyrimidin-2-yI amino)-3 -ethoxy-phenyl ]-morpholin-4-yl methanone, 30 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -hydroxy-phenyl]-morpholin-4-yl methanone, [4-(5 -Chloro-4-m ethyl ami no-pyrimi din-2-yl amino)-3 -i sopropoxy-ph enyl ]-morpholin -4-yl methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl 35 methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-hydroxy-piperidin- 1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(octahydro-pyrido [1,2 a]pyrazin-2-yl)-methanone, 164 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-hydroxy-piperidin- 1 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4,4-dimethyl-piperidin 1 -yl)-methanone, 5 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3,5-dimethyl-piperidin 1 -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]- [4-(1 -hydroxy- 1-methyl ethyl)-piperidin- 1 -yl]-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-hydroxy-pyrrolidin 10 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-methyl-piperidin-1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-piperidin- 1-yl methanone, 15 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4,4-difluoro-piperidin 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-methyl-piperidin-1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-methoxy-piperidin- 1 20 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3,3-difluoro-piperidin I -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-fluoro-piperidin- 1 yl)-methanone, 25 [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(3 -methoxy-piperidin- 1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-ethyl-piperazin- 1-yl) methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-trifluoromethyl 30 piperidin- I -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-[4-(2-hydroxy-ethyl) piperazin-1 -yl]-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-methyl-pyrrolidin- 1 yl)-methanone, 35 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-hydroxymethyl piperidin- 1 -yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(2-methyl-piperidin- 1 yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-pyrrolidin- 1-yl 40 methanone, 165 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-methanesulfonyl piperazin-1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-trifluoromethyl pyrrolidin- 1 -yl)-methanone, 5 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-[4-(2,2,2-trifluoro ethyl)-piperazin- 1-yl] -methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-methyl-morpholin-4 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2,6-dimethyl 10 morpholin-4-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2,2-diethyl-morpholin 4-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-hydroxymethyl morpholin-4-yl)-methanone, 15 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-isobutyl-morpholin 4-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-hydroxymethyl morpholin-4-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3,3-dimethyl 20 morpholin-4-yl)-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl] -(4-methyl-piperazin- 1 yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-isopropyl-piperazin I -yl)-methanone, 25 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-piperazin- 1-yl methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-oxa-8-aza bicyclo[3.2.1 ]oct-8-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-((S)-3-methyl 30 morpholin-4-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-oxa-5-aza bicyclo[2.2. 1]hept-5-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(8-oxa-3-aza bicyclo[3.2.1 ]oct-3-yl)-methanone, 35 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-((R)-3-methyl morpholin-4-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4 cyclopropanecarbonyl-piperazin- 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(3-morpholin-4-yl 40 azetidin-1-yl)-methanone, 166 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-[4-(1-methyl-piperidin 4-yl)-piperazin- 1 -yl]-methanone, [4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(3,3 -difluoro-azetidin- 1 yl)-methanone, 5 [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-dimethylamino piperidin- 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(4-piperidin-4-yl piperazin- 1 -yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-(2-oxa-6-aza 10 spiro[3.3]hept-6-yl)-methanone, [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-trifluoromethoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Chloro-4-propoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [4-(5-Chloro-4-propylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl 15 methanone, [4-(5-Cyclobutyl-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Cyclobutyl-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, 20 [4-(5-Cyclopropyl-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Cyclopropyl-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, [4-(5-Fluoro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl 25 methanone, [4-(5 -Fluoro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-phenyl]-(4-hydroxy-piperidin- 1 yl)-methanone, [4-(5 -Iodo-4-methoxy-pyrimi din-2-ylamino)-3 -methoxy-phenyl]-morpholin-4-yl -methanone, [4-(5-Iodo-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, 30 [4-[5-Chloro-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino]-3-(2,2,2-trifluoro-ethoxy) phenyl]-morpholin-4-yl-methanone, [5-Chloro-2-ethoxy-4-(4-methylamino-5 -tri fluoromethyl-pyrimidin-2-yl amino)-phenyl] morpholin-4-yl-methanone, [5-Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] 35 piperazin-1 -yl-methanone, [5-Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-(2,6 dimethyl-morpholin-4-yl)-methanone, [5-Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, 167 [5-Chloro-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-methoxy-phenyl] morpholin-4-yl-methanone, [5-Chloro-4-(5-chloro-4-ethylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-morpholin-4-yl methanone, 5 [5-Chloro-4-(5-chloro-4-methoxy-pyrimidin-2-ylamino)-2-methoxy-phenyl]-morpholin-4-yl methanone, [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-morpholin-4 yl-methanone, [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(4,4-difluoro 10 piperidin- 1 -yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-piperazin- l-yl methanone, [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(4 dimethylamino-piperidin- 1 -yl)-methanone, 15 [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(3-hydroxy pyrrolidin- 1 -yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-pheny]-pyrrolidin- 1 yl-methanone, [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(4-hydroxy 20 piperidin- 1 -yl)-methanone, [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(2 hydroxymethyl-morpholin-4-yl)-methanone, [5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-pheny]-[ 1,4]oxazepan 4-yl-methanone, 25 [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-((2R,6S)-2,6 dimethyl-morpholin-4-yl)-methanone, [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-(3-hydroxy azetidin- I -yl)-methanone, [5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-phenyl]-((3R,5S) 30 dimethyl-piperazin- 1 -yl)-methanone, [5-Ethoxy-2-fluoro-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [5-Ethoxy-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-phenyl] morpholin-4-yl-methanone, 35 {4-[5-Bromo-4-(2-methoxy-ethoxy)-pyrimidin-2-ylamino]-3-methoxy-phenyl} -morpholin-4-yl methanone, {4-[5-Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino]-2-fluoro-5-methoxy-phenyl} morpholin-4-yl-methanone, {4-[5-Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino]-3-ethoxy-phenyl} -morpholin-4 40 yl-methanone, 168 {4-[5 -Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino]-3 -isopropoxy-phenyl} morpholin-4-yl-methanone, {4-[5 -Bromo-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} -morpholin 4-yl-methanone, 5 f 4-[5 -Chloro-4-( 1 -methyl-cyclobutylamino)-pyrimidin-2-ylamino]-3-methoxy-pheny} morpholin-4-yl-methanone, {4-[5 -Chloro-4-(2,2,2-trifluoro-ethylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} morpholin-4-yl-methanone, {4-[5 -Chloro-4-(2,2-difluoro-ethylamino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} -morpholin 10 4-yl-methanone, {4- [5-Chloro-4-(2-cyclopropyl-ethylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} morpholin-4-yl-methanone, {4-I5 -Chloro-4-(2-methanesulfonyl-ethylamino)-pyrimidin-2-ylamino]-3-methoxy-pheny} morpholin-4-yl-methanone, 15 {4-[5 -Chloro-4-(2-methoxy-ethoxy)-pyrimidin-2-ylamino]-3-cyclobutoxy-phenyl -morpholin-4 yl-methanone, {4-[5 -Chloro-4-(2-methoxy-ethoxy)-pyrimidin-2-ylamino]-3 -methoxy-phcnyl} -morpholin-4-yl methanone, {4-[5 -Chloro-4-(2-methoxy-ethylamino)-pyrimidin-2-ylamino] -3 -cyclobutoxy-phenyl} 20 morpholin-4-yl-methanone, {4-[5 -Chloro-4-(2-mcthoxy-cthylamino)-pyrimidin-2-ylamino] -3 -mcthoxy-phenyl} -morpholin 4-yl-methanone, {4-[5 -Chloro-4-(2-methoxy-propylamino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} -morpholin 4-yi-methanone, 25 {4-[5 -Chloro-4-(cyclobutylmcthyl-amino)-pyrimidin-2--ylamino]-3-mcthoxy-phenyl} morpholin-4-yl-methanone, {4-[5 -Chloro-4-(cyclopentylmethyl-amino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} morpholin-4-yl -meth anon e, {4-[5 -Chloro-4-(cyclopropylmethyl-amino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} 30 morpholin-4-yl-methanone, {4-[5 -Chloro-4-(tetrahydro-furan-3 -ylamino)-pyrimidin-2-ylamino] -3 -methoxy-phenyl} motpholin-4-yl-methanone, {4-[5 -Chloro-4-(tetrahydro-pyran-3-ylamino)-pyrimidin-2-ylamino]-3 -methoxy-phenyl} morpholin-4-yl-methanone, 35 {4-[5 -Chloro-4-(tetrahydro-pyran-4-yloxy)-pyrimidin-2-ylamino]-3 -methoxy-phenyl) morpholin-4-yl-methanone, 1 -(4-(5 -bromo-4-methoxypyrimidin-2-ylamino)-3 -methoxybenzoyl)piperidine-4-carbonitrile, 1 -[2-Fluoro-5 -methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-benzoyl] pyrrolidine-3 -carbonitrile, 169 1 -[3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-benzoyl]-piperidine-4 carbonitrile, 1 -[4-(5 -Bromo-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzoyl]-piperidine-4 carbonitrile, 5 1 -[4-(5 -Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzoyl]-piperidine-4 carbonitrile, 1 -[5-Chloro-2-methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-benzoyl] pyrrolidine-3 -carbonitrile, 1 -[5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-benzoyl]-piperidine 10 4-carbonitrile, 1 -[5-Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2--ylamino)-2-methoxy-benzoyl]-pyrrolidine 3 -carbonitrile, 1- {2- [2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino] -4-methylamino-pyrimidin-5 -yl} ethanone, 15 1 -{4- [4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzoyl] -piperazin- Il-yl} ethanone, 2-(2-methoxy-4-(2,2,6,6-tctrafluoromorpholine-4-carbonyl)phenylamino)-4 (methylamino)pyrimidine-5 -carbonitrile, 2-(2-methoxy-4-(morpholine-4-carbonyl)phenylamino)-4-(methylamino)pyrimidine-5 20 carbonitrile, 2-(4-((3 S ,4S)-3 ,4-difluoropyrrolidinc- 1 -carbonyl)-2-mcthoxyphcnylamino)-4 (methylamino)pyrimidine-5 -carbonitrile, 2-(4-(4,4-difluoropiperidine- 1 -carbonyl)-2-methoxyphenylamino)-4-(methylamino)pyrimidine 5 -carbonitri le, 25 2-[2,5 -Dimcthoxy-4-(4-mcthylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl] -1I morpholin-4-yl-ethanone, 2-[2-Methoxy-4-(morpholine-4-carbonyl)-phenylamino]-4-methylamino-pyrimidine-5 carbonitrile, 2-[2-Methoxy-4-(piperidine- 1 -carbonyl)-phenylamino]-4-methylamino-pyrimidine-5 30 carbonitrile, 2-[2-Methoxy-4-(pyrrolidine- 1 -carbonyl)-phenylamino] -4-methylamino-pyrimidine-5 carbonitrile, 2-[3-Methoxy-4-(4-methylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-phenyl]- 1 -morpholin 4-yl-ethanone, 35 2-[4-((2R,6S)-2,6-Dimethyl-morpholine-4-carbonyl)-5 -fluoro-2-methoxy-phenylamino]-4 methylamino-pyrimidine-5-carbonitrile, 2-[4-((2R,6S)-2,6-Dimethyl-morpholine-4-carbonyl)-5 -fluoro-2-methoxy-phenylamino]-4 ethylamino-pyrimidine-5-carbonitrile, 2-[4-((R)-3-Fluoro-pyrrolidine- 1 -carbonyl)-2-methoxy-phenylamino] -4-methylamino 40 pyrimidine-5-carbonitrile, 170 2-[4-((S)-3-Fluoro-pyrrolidine-1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino pyrimidine-5-carbonitrile, 2-[4-(3,3-Difluoro-azetidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino-pyrimidine 5-carbonitrile, 5 2-[4-(3,3-Difluoro-pyrrolidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino pyrimidine-5-carbonitrile, 2-[4-(3-Fluoro-azetidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino-pyrimidine-5 carbonitrile, 2-[4-(5-Bromo-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]- 1 -morpholin-4-yl-ethanone, 10 2-[4-(5-Bromo-4-methylamino-pyrimidin-2-ylamino)-2,5-dimethoxy-phenyl]- 1 -morpholin-4-yl ethanone, 2-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-2,5-dimethoxy-phenyl] -1 -morpholin-4-yl ethanone, 2-[4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]- 1 -morpholin-4-yl-ethanone, 15 2-[4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-2,5-dimethoxy-phenyl]- 1 -morpholin-4-yl ethanone, 2-[4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-phenyl]- 1 -morpholin-4-yl ethanone, 2-[4-(Azetidine- 1 -carbonyl)-2-methoxy-phenylamino]-4-methylamino-pyrimidine-5-carbonitrile, 20 2-[5-Fluoro-2-methoxy-4-(morpholine-4-carbonyl)-phenylamino]-4-methylamino-pyrimidine-5 carbonitrile, 2-Fluoro-5-methoxy-N-(2-methoxy-ethyl)-N-methyl-4-(4-methylamino-5-trifluoromethyl pyrimidin-2-ylamino)-benzamide, 2-Fluoro-5 -methoxy-N-methyl-4-(4-methyl amino-5 -trifluoromethyl-pyrimidin-2-ylamino) 25 benzamide, 2-fluoro-N-(2-hydroxy-2-methylpropyl)-5-methoxy-N-methyl-4-(4-(methylamino)-5 (trifluoromethyl)pyrimidin-2-ylamino)benzamide, 3 -Methoxy-4-(4-methyl amino-5 -trifluoromethyl-pyrimidin-2-yl amino)-N-oxetan-3 -yl benzamide, 30 3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-N-(1 -methyl-piperidin-4 yl)-benzamide, 3-Methoxy-N-(2-methoxy-ethyl)-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino) benzamide, 3-Methoxy-N-(2-methoxy-ethyl)-N-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2 35 ylamino)-benzamide, 4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-N-(2-methoxy ethyl)-N-methyl-benzamide, 4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl methanone, 171 4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-3 -methoxy-N-(2-methoxy-ethyl)-N methyl-benzamide, 4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-N,N,3 -trimethylbenzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-benzamide, 5 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-N-(tetrahydro-pyran-3 -yl) benzamnide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-N,N-dimethyl-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-N-methyl-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-3 -methoxy-N-oxetan-3 -yl-benzamide, 10 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-N-cyclopropyl-3 -methoxy-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-N-ethyl-3 -methoxy-benzamide, 4-(5-Chloro-4-methylamino-pyrimidin-2-ylamino)-N-isopropyl-3 -methoxy-benzamide, 4-(5-Cyano-4-ethylamino-pyrimidin-2-ylamino)-2-fluoro-5 -methoxy-N,N-dimethyl-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2--ylamino)-2-fluoro-5 -methoxy-N,N-dimethyl-benzamide, 15 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-N,N-dimethyl-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2--ylamino)-3-methoxy-N-methyl-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-(2,2-difluoro-ethyl)-3 -methoxy-bcnzamidc, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-(3 ,3 -difluoro-cyclobutyl)-3 -methoxy benzamnide, 20 4-(5-Cyano-4-methylamino-pyrimidin-2--ylamino)-N,N-diethyl-3 -methoxy-benzamide, 4-(5-Cyano-4-mcthylamino-pyrimidin-2--ylamino)-N-cyclopropylmcthyl-3 -mcthoxy-bcnzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-ethyl-3-methoxy-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2--ylamino)-N-ethyl-3-methoxy-N-methyl-benzamide, 4-(5-Cyano-4-methyl amino-pyrimi din-2 -ylamino)-N-ethyl -N-isopropyl-3 -methoxy-benzami de, 25 4-(5-Cyano-4-methylamino-pyrimidin-2--ylamino)-N-isopropyl-3 -methoxy-benzamide, 4-(5-Cyano-4-methylamino-pyrimidin-2-ylamino)-N-isopropyl-3 -methoxy-N-methyl-benzamide, 4-Lthylamino-2-[5-fluoro-2--methoxy-4-(morpholine-4-carbonyl)-phenylamino]-pyrimdine-5 carbonitrile, 4-Methoxy-2-[2-methoxy-4-(morpholine-4-carbonyl)-phenylamino] -pyrimidine-5 -carbonitrile, 30 5 -Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-N-( 1-methyl piperidin-4-yl)-benzamide, 5 -Chloro-2-methoxy-4-(4-metbylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-N-oxetan-3 -yl benzamnide, 5 -Chloro-2-methoxy-N,N-dimethyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino) 35 benzamnide, 5 -Chloro-4-(4-ethylamino-5 -trifluoromethyl-pyrimidin-2-ylamino)-2-methoxy-N-(2-methoxy ethyl)-benzamide, 5 -chloro-4-(5 -chloro-4-methoxypyrimidin-2-ylamino)-2-methoxy-N -methylbenzamide, 5 -Chloro-4-(5 -chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N,N-dimethyl 40 benzamnide, 172 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-(2-methoxy-ethyl) benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-methyl-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-oxetan-3-yl 5 benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-(1 -methyl-piperidin 4-yl)-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-(2-methoxy-ethyl)-N methyl-benzamide, 10 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-N-(1-methyl cyclobutyl)-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-N-(1 -cyano-cyclopropyl)-2 methoxy-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-2-methyl-propyl)-2 15 methoxy-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-ethyl)-2-methoxy-N methyl-benzamide, 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-N-(2-hydroxy-propyl)-2-methoxy benzamide, 20 5-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-N-cyclopropyl-2-methoxy benzamide, 5-Chloro-N-(I-cyano-cyclopropyl)-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin 2-ylamino)-benzamide, 5-Chloro-N-(1 -cyano-cyclopropyl)-2-methoxy-4-(4-methy amino-5 -tri fluoromethyl-pyrimidin 25 2-ylamino)-benzamide, 5-Chloro-N-(2-hydroxy-2-methyl-propyl)-2-methoxy-4-(4-methylamino-5-trifluoromethyl pyrimidin-2-ylamino)-benzamide, 5-Chloro-N-(2-hydroxy-2-methyl-propyl)-2-methoxy-N-methyl-4-(4-methylamino-5 trifluoromethyl-pyrimidin-2-ylamino)-benzamide, 30 5-Chloro-N-cyclopropyl-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-methoxy benzamide, Azetidin- 1-yl - [4-(5 -chloro-4-methylamino-pyrimi din-2-yl amino)-3 -methoxy-phenyl] -methanone, N-(3,3-Difluoro-cyclobutyl)-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2 ylamino)-benzamide, 35 N-(3-aminopropyl)-4-(5-chloro-4-(methylamino)pyrimidin-2-ylamino)-3-methoxybenzamide, N-(3-Amino-propyl)-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-benzamide, N-(3-Amino-propyl)-5-chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy benzamide, N-(4,4-Difluoro-cyclohexyl)-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2 40 ylamino)-benzamide, 173 N,N-Diethyl-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-benzamide, N-Ethyl-2-fluoro-5-methoxy-N-(2-methoxy-ethyl)-4-(4-methylamino-5-trifluoromethyl pyrimidin-2-ylamino)-benzamide, N-Ethyl-3-methoxy-N-methyl-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino) 5 benzamide, N-Ethyl-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-N-(2 methoxy-ethyl)-benzamide, N-tert-Butyl-4-(5-cyano-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-benzamide, and N-tert-Butyl-5-chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-2-methoxy-benzamide, 10 or a pharmaceutically acceptable salt thereof.

21. A compound according to any of claims 1 to 20, selected from the group consisting of [3-Methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl methanone, (5-chloro-2-methoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 15 ylamino)phenyl)(perdeuteromorpholino)methanone, (5-fluoro-2-methoxy-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2 ylamino)phenyl)(morpholino)methanone, [2-Fluoro-3-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, 20 [3-Chloro-4-(5-chloro-4-methylamino-pyrimidin-2-ylamino)-phenyl]-morpholin-4-yl-methanone, [3-Isopropoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl]-morpholin-4 yl-methanone, [4-(4-Ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-fluoro-5-methoxy-phenyl] morpholin-4-yl-methanone, 25 [4-(5-Chloro-4-methoxy-pyrimidin-2-ylamino)-3-methoxy-phenyl]-morpholin-4-yl-methanone, [5-Chloro-2-methoxy-4-(4-methylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-phenyl] morpholin-4-yl-methanone, [5-Chloro-4-(4-ethylamino-5-trifluoromethyl-pyrimidin-2-ylamino)-2-methoxy-phenyl] morpholin-4-yl-methanone, 30 [5-Ethoxy-2-fluoro-4-(4-methylamino-5 -trifluoromethyl -pyrimi din-2-ylamino)-pbenyl] morpholin-4-yl-methanone, 2-(2-methoxy-4-(morpholine-4-carbonyl)phenylamino)-4-(methylamino)pyrimidine-5 carbonitrile, and N-tert-Butyl-4-(5-cyano-4-methylamino-pyrimidin-2-ylamino)-3-methoxy-benzamide, 35 or a pharmaceutically acceptable salt thereof.

22. A composition comprising: 174 (a) a pharmaceutically acceptable carrier; and (b) a compound of claim 1.

23. A compound of formula I according to any of claims 1-21 for use as therapeutically active substance. 5

24. A method for treating Parkinson's disease, said method comprising administering to a subject in need thereof an effective amount of a compound of claim 1.

25. Use of a compound of formula I according to any of claims 1-21 for the manufacture of a medicament for the therapeutic and/or prophylactic treatment of Parkinson's disease.

26. A compound of formula I according to claims 1-21 for the use as therapeutically active 10 substance for the therapeutic and/or prophylactic treatment of Parkinson's disease.

27. The invention as described herein.