AU2012327200A8 - Binding molecules for BCMA and CD3 - Google Patents

Abstract

Abstract The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule.

Description

New PCT-application Amgen Research GmbH Boehringer Ingelheim International GmbH Our Ref.: MIM14333PCT 5 Binding molecules for BCMA and CD3 The present invention relates to a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein the first binding domain is capable of binding to epitope 10 cluster 3 of BCMA, and the second binding domain is capable of binding to the T cell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the binding molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit 15 comprising said binding molecule. BCMA (B-cell maturation antigen, TNFRSF17, CD269) is a transmembrane protein belonging to the TNF receptor super family. BCMA is originally reported as an integral membrane protein in the Golgi apparatus of human mature B lymphocytes, i.e., as an intracellular protein (Gras et al., 20 (1995) International Immunol 7(7):1093-1105) showing that BCMA seems to have an important role during B-cell development and homeostasis. The finding of Gras et al. might be associated with the fact that the BCMA protein that was described in Gras et al. is, because of a chromosomal translocation, a fusion protein between BCMA and IL-2. Meanwhile BCMA is, however, established to be a B-cell marker that is essential for B-cell development and 25 homeostasis (Schliemann et al., (2001) Science 293 (5537):2111-2114) due to its presumably essential interaction with its ligands BAFF (B cell activating factor), also designated as TALL-1 or TNFSF13B, and APRIL (A proliferation-inducing ligand). BCMA expression is restricted to the B-cell lineage and mainly present on plasma cells and plasmablasts and to some extent on memory B-cells, but virtually absent on peripheral and 30 naive B-cells. BCMA is also expressed on multiple myeloma (MM) cells. Together with its family members transmembrane activator and cyclophylin ligand interactor (TACI) and B cell activation factor of TNF family receptor (BAFF-R), BCMA regulates different aspects of humoral immunity, B-cell development and homeostasis. Expression of BCMA appears rather late in B-cell differentiation and contributes to the long term survival of plasmablasts and plasma cells in the 35 bone marrow. Targeted deletion of the BCMA gene in mice does not affect the generation of mature B-cells, the quality and magnitude of humoral immune responses, formation of germinal 1 center and the generation of short-lived plasma cells. However, such mice have significantly reduced numbers of long-lived plasma cells in the bone marrow, indicating the importance of BCMA for their survival (O'Connor et al., 2004). In line with this finding, BCMA also supports growth and survival of multiple myeloma (MM) 5 cells. Novak et al found that MM cell lines and freshly isolated MM cells express BCMA and TACI protein on their cell surfaces and have variable expression of BAFF-R protein on their cell surface (Novak et al., (2004) Blood 103(2):689-694). Multiple myeloma (MM) is the second most common hematological malignancy and constitutes 2% of all cancer deaths. MM is a heterogenous disease and caused by mostly by chromosome 10 translocations inter alia t(1 1;14),t(4;14),t(8;14),del(13),del(17) (Drach et al., (1998) Blood 92(3):802-809; Gertz et al., (2005) Blood 106(8):2837-2840; Facon et al., (2001) Blood 97(6):1566-1571). MM-affected patients may experience a variety of disease-related symptoms due to, bone marrow infiltration, bone destruction, renal failure, immunodeficiency, and the psychosocial burden of a cancer diagnosis. As of 2006, the 5-year relative survival rate for MM 15 was approximately 34% highlighting that MM is a difficult-to-treat disease where there are currently no curative options. Exciting new therapies such as chemotherapy and stem cell transplantation approaches are becoming available and have improved survival rates but often bring unwanted side effects, and thus MM remains still incurable (Lee et al., (2004) J Natl Compr Canc Netw 8 (4): 379-383). To 20 date, the two most frequently used treatment options for patients with multiple myeloma are combinations of steroids, thalidomide, lenalidomide, bortezomib or various cytotoxic agents, and for younger patients high dose chemotherapy concepts with autologous stem cell transplantation. Most transplants are of the autologous type, i.e. using the patient's own cells. Such transplants, 25 although not curative, have been shown to prolong life in selected patients. They can be performed as initial therapy in newly diagnosed patients or at the time of relapse. Sometimes, in selected patients, more than one transplant may be recommended to adequately control the disease. Chemotherapeutic agents used for treating the disease are Cyclophosphamid, Doxorubicin, 30 Vincristin and Melphalan, combination therapies with immunomodulating agents such as thalidomide (Thalomid@), lenalidomide (Revlimid@), bortezomib (Velcade@) and corticosteroids (e.g. Dexamethasone) have emerged as important options for the treatment of myeloma, both in 2 newly diagnosed patients and in patients with advanced disease in whom chemotherapy or transplantation have failed. The currently used therapies are usually not curative. Stem cell transplantation may not be an option for many patients because of advanced age, presence of other serious illness, or other 5 physical limitations. Chemotherapy only partially controls multiple myeloma, it rarely leads to complete remission. Thus, there is an urgent need for new, innovative treatments. Bellucci et al. (Blood, 2005; 105(10) identified BCMA-specific antibodies in multiple myeloma patients after they had received donor lymphocyte infusions (DLI). Serum of these patients was capable of mediating BCMA-specific cell lysis by ADCC and CDC and was solely detected in 10 patients with anti-tumor responses (4/9), but not in non-responding patients (0/6). The authors speculate that induction of BCMA-specific antibodies contributes to elimination of myeloma cells and long-term remission of patients. Ryan et al. (Mol. Cancer Ther. 2007: 6(11) reported the generation of an antagonistic BCMA specific antibody that prevents NF-KB activation which is associated with a potent pro-survival 15 signaling pathway in normal and malignant B-cells. In addition, the antibody conferred potent antibody-dependent cell-mediated cytotoxicity (ADCC) to multiple myeloma cell lines in vitro which was significantly enhanced by Fc-engineering. Other approaches in fighting blood-borne tumors or autoimmune disorders focus on the interaction between BAFF and APRIL, i.e., ligands of the TNF ligand super family, and their 20 receptors TACI, BAFF-R and BCMA which are activated by BAFF and/or APRIL. For example, by fusing the Fc-domain of human immunoglobulin to TACI, Zymogenetics, Inc. has generated Atacicept (TACI-Ig) to neutralize both these ligands and prevent receptor activation. Atacicept is currently in clinical trials for the treatment of Systemic Lupus Erythematosus (SLE, phase Ill), multiple sclerosis (MS, phase 11) and rheumatoid arthritis (RA, phase 11), as well as in phase 1 25 clinical trials for the treatment of the B-cell malignancies chronic lymphocytic leukaemia (CLL), non-Hodgkins lymphoma (NHL) and MM. In preclinical studies atacicept reduces growth and survival of primary MM cells and MM cell lines in vitro (Moreaux et al, Blood, 2004, 103) and in vivo (Yaccoby et al, Leukemia, 2008, 22, 406-13), demonstrating the relevance of TACI ligands for MM cells. Since most MM cells and derived cell lines express BCMA and TACI, both 30 receptors might contribute to ligand-mediated growth and survival. These data suggest that antagonizing both BCMA and TACI might be beneficial in the treatment of plasma cell disorders. 3 In addition, BCMA-specific antibodies that cross react with TACI have been described (WO 02/066516). Human Genome Sciences and GlaxoSmithKline have developed an antibody targeting BAFF which is called Belimumab. Belimumab blocks the binding of soluble BAFF to its receptors 5 BAFF-R, BCMA and TACI on B cells. Belimumab does not bind B cells directly, but by binding BAFF, belimumab inhibits the survival of B cells, including autoreactive B cells, and reduces the differentiation of B cells into immunoglobulin-producing plasma cells. Nevertheless, despite the fact that BCMA; BAFF-R and TACI, i.e., B cell receptors belonging to the TNF receptor super family, and their ligands BAFF and APRIL are subject to therapies in 10 fighting against cancer and/or autoimmune disorders, there is still a need for having available further options for the treatment of such medical conditions. Accordingly, there is provided herewith means and methods for the solution of this problem in the form of a binding molecule which is at least bispecific with one binding domain to cytotoxic cells, i.e., cytotoxic T cells, and with a second binding domain to BCMA. 15 Thus, in a first aspect the present invention provides a binding molecule which is at least bispecific comprising a first and a second binding domain, wherein (a) the first binding domain is capable of binding to epitope cluster 3 of BCMA (CQLRCSSNTPPLTCQRYC) (SEQ ID NO:1016); and 20 (b) the second binding domain is capable of binding to the T cell CD3 receptor complex; and wherein epitope cluster 3 of BCMA corresponds to amino acid residues 24 to 41 of the sequence as depicted in SEQ ID NO: 1002. It must be noted that as used herein, the singular forms "a", "an", and "the", include plural 25 references unless the context clearly indicates otherwise. Thus, for example, reference to "a reagent" includes one or more of such different reagents and reference to "the method" includes reference to equivalent steps and methods known to those of ordinary skill in the art that could be modified or substituted for the methods described herein. 30 Unless otherwise indicated, the term "at least" preceding a series of elements is to be understood to refer to every element in the series. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific 4 embodiments of the invention described herein. Such equivalents are intended to be encompassed by the present invention. The term "and/or" wherever used herein includes the meaning of "and", "or" and "all or any 5 other combination of the elements connected by said term". The term "about" or "approximately" as used herein means within ±20%, preferably within ±15%, more preferably within ±10%, and most preferably within ±5% of a given value or range. 10 Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integer or step. When used herein the term "comprising" can be substituted with the term "containing" or "including" or sometimes when used herein with 15 the term "having". When used herein "consisting of" excludes any element, step, or ingredient not specified in the claim element. When used herein, "consisting essentially of' does not exclude materials or steps that do not materially affect the basic and novel characteristics of the claim. 20 In each instance herein any of the terms "comprising", "consisting essentially of" and "consisting of' may be replaced with either of the other two terms. Epitope cluster 3 is comprised by the extracellular domain of BCMA. The "BCMA extracellular 25 domain" or "BCMA ECD" refers to a form of BCMA which is essentially free of transmembrane and cytoplasmic domains of BCMA. It will be understood by the skilled artisan that the transmembrane domain identified for the BCMA polypeptide of the present invention is identified pursuant to criteria routinely employed in the art for identifying that type of hydrophobic domain. The exact boundaries of a transmembrane domain may vary but most likely by no more than 30 about 5 amino acids at either end of the domain specifically mentioned herein. A preferred BCMA ECD is shown in SEQ ID NO: 1007. The T cell CD3 receptor complex is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3y chain, a CD36 chain, and two CD3E (epsilon) 5 chains. These chains associate with a molecule known as the T cell receptor (TCR) and the ( chain to generate an activation signal in T lymphocytes. The redirected lysis of target cells via the recruitment of T cells by bispecific molecules involves 5 cytolytic synapse formation and delivery of perforin and granzymes. The engaged T cells are capable of serial target cell lysis, and are not affected by immune escape mechanisms interfering with peptide antigen processing and presentation, or clonal T cell differentiation; see, for example, WO 2007/042261. 10 The term "binding molecule" in the sense of the present disclosure indicates any molecule capable of (specifically) binding to, interacting with or recognizing the target molecules BCMA and CD3. According to the present invention, binding molecules are preferably polypeptides. Such polypeptides may include proteinaceous parts and non-proteinaceous parts (e.g. chemical linkers or chemical cross-linking agents such as glutaraldehyde). 15 A binding molecule, so to say, provides the scaffold for said one or more binding domains so that said binding domains can bind/interact with the target molecules BCMA and CD3. For example, such a scaffold could be provided by protein A, in particular, the Z-domain thereof (affibodies), ImmE7 (immunity proteins), BPTI/APPI (Kunitz domains), Ras-binding protein AF-6 (PDZ-domains), charybdotoxin (Scorpion toxin), CTLA-4, Min-23 (knottins), lipocalins 20 (anticalins), neokarzinostatin, a fibronectin domain, an ankyrin consensus repeat domain or thioredoxin (Skerra, Curr. Opin. Biotechnol. 18, 295-304 (2005); Hosse et al., Protein Sci. 15, 14-27 (2006); Nicaise et al., Protein Sci. 13, 1882-1891 (2004) ; Nygren and Uhlen, Curr. Opin. Struc. Biol. 7, 463-469 (1997)). A preferred binding molecule is an antibody. It is envisaged that the binding molecule is produced by (or obtainable by) phage-display or 25 library screening methods rather than by grafting CDR sequences from a pre-existing (monoclonal) antibody into a scaffold, for example, a scaffold as disclosed herein. The term "bispecific" as used herein refers to a binding molecule which comprises at least a first and a second binding domain, wherein the first binding domain is capable of binding to one 30 antigen or target, and the second binding domain is capable of binding to another antigen or target. The "binding molecule" of the invention also comprises multispecific binding molecules such as e.g. trispecific binding molecules, the latter ones including three binding domains. It is also envisaged that the binding molecule of the invention has, in addition to its function to 35 bind to the target molecules BCMA and CD3, a further function. In this format, the binding 6 molecule is a tri-or multifunctional binding molecule by targeting plasma cells through binding to BCMA, mediating cytotoxic T cell activity through CD3 binding and providing a further function such as a fully functional Fc constant domain mediating antibody-dependent cellular cytotoxicity through recruitment of effector cells like NK cells, a label (fluorescent etc.), a therapeutic agent 5 such as, e.g. a toxin or radionuclide, and/or means to enhance serum half-life, etc. The term "binding domain" characterizes in connection with the present invention a domain which is capable of specifically binding to / interacting with a given target epitope or a given target site on the target molecules BCMA and CD3. 10 Binding domains can be derived from a binding domain donor such as for example an antibody, protein A, ImmE7 (immunity proteins), BPTI/APPI (Kunitz domains), Ras-binding protein AF-6 (PDZ-domains), charybdotoxin (Scorpion toxin), CTLA-4, Min-23 (knottins), lipocalins (anticalins), neokarzinostatin, a fibronectin domain, an ankyrin consensus repeat domain or thioredoxin (Skerra, Curr. Opin. Biotechnol. 18, 295-304 (2005); Hosse et al., Protein Sci. 15, 15 14-27 (2006); Nicaise et al., Protein Sci. 13, 1882-1891 (2004); Nygren and Uhlen, Curr. Opin. Struc. Biol. 7, 463-469 (1997)). A preferred binding domain is derived from an antibody. It is envisaged that a binding domain of the present invention comprises at least said part of any of the aforementioned binding domains that is required for binding to/interacting with a given target epitope or a given target site on the target molecules BCMA and CD3. 20 It is envisaged that the binding domain of the aforementioned binding domain donors is characterized by that part of these donors that is responsible for binding the respective target, i.e. when that part is removed from the binding domain donor, said donor loses its binding capability. "Loses" means a reduction of at least 50% of the binding capability when compared 25 with the binding donor. Methods to map these binding sites are well known in the art - it is therefore within the standard knowledge of the skilled person to locate/map the binding site of a binding domain donor and, thereby, to "derive" said binding domain from the respective binding domain donors. 30 The term "epitope" refers to a site on an antigen to which a binding domain, such as an antibody or immunoglobulin or derivative or fragment of an antibody or of an immunoglobulin, specifically binds. An "epitope" is antigenic and thus the term epitope is sometimes also referred to herein as "antigenic structure" or "antigenic determinant". Thus, the binding domain is an "antigen interaction-site". Said binding/interaction is also understood to define a "specific recognition". In 35 one example, said binding domain which (specifically) binds to / interacts with a given target 7 epitope or a given target site on the target molecules BCMA and CD3 is an antibody or immunoglobulin, and said binding domain is a VH and/or VL region of an antibody or of an immunoglobulin. "Epitopes" can be formed both by contiguous amino acids or non-contiguous amino acids 5 juxtaposed by tertiary folding of a protein. A "linear epitope" is an epitope where an amino acid primary sequence comprises the recognized epitope. A linear epitope typically includes at least 3 or at least 4, and more usually, at least 5 or at least 6 or at least 7, for example, about 8 to about 10 amino acids in a unique sequence. A "conformational epitope", in contrast to a linear epitope, is an epitope wherein the primary 10 sequence of the amino acids comprising the epitope is not the sole defining component of the epitope recognized (e.g., an epitope wherein the primary sequence of amino acids is not necessarily recognized by the binding domain). Typically a conformational epitope comprises an increased number of amino acids relative to a linear epitope. With regard to recognition of conformational epitopes, the binding domain recognizes a three-dimensional structure of the 15 antigen, preferably a peptide or protein or fragment thereof (in the context of the present invention, the antigen for one of the binding domains is comprised within the BCMA protein). For example, when a protein molecule folds to form a three-dimensional structure, certain amino acids and/or the polypeptide backbone forming the conformational epitope become juxtaposed enabling the antibody to recognize the epitope. Methods of determining the 20 conformation of epitopes include, but are not limited to, x-ray crystallography, two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy and site-directed spin labelling and electron paramagnetic resonance (EPR) spectroscopy. Moreover, the provided examples describe a further method to test whether a given binding domain binds to one or more epitope cluster(s) of a given protein, in particular BCMA. 25 In one aspect, the first binding domain of the present invention is capable of binding to epitope cluster 3 of human BCMA, preferably human BCMA ECD. Accordingly, when the respective epitope cluster in the human BCMA protein is exchanged with the respective epitope cluster of a murine BCMA antigen (resulting in a construct comprising human BCMA, wherein human 30 epitope cluster 3 is replaced with murine epitope cluster 3; see SEQ ID NO: 1011), a decrease in the binding of the binding domain will occur. Said decrease is preferably at least 10%, 20%, 30%, 40%, 50%; more preferably at least 60%, 70%, 80%, 90%, 95% or even 100% in comparison to the respective epitope cluster in the human BCMA protein, whereby binding to the respective epitope cluster in the human BCMA protein is set to be 100%. It is envisaged that 35 the aforementioned human BCMA/murine BCMA chimeras are expressed in CHO cells. It is 8 also envisaged that the human BCMA/murine BCMA chimeras are fused with a transmembrane domain and/or cytoplasmic domain of a different membrane-bound protein such as EpCAM; see Figure 2a. A method to test this loss of binding due to exchange with the respective epitope cluster of a 5 non-human (e.g. murine) BCMA antigen is described in the appended Examples, in particular in Examples 1-3. A further method to determine the contribution of a specific residue of a target antigen to the recognition by a given binding molecule or binding domain is alanine scanning (see e.g. Morrison KL & Weiss GA. Cur Opin Chem Biol. 2001 Jun;5(3):302-7), where each residue to be analyzed is replaced by alanine, e.g. via site-directed mutagenesis. Alanine is 10 used because of its non-bulky, chemically inert, methyl functional group that nevertheless mimics the secondary structure references that many of the other amino acids possess. Sometimes bulky amino acids such as valine or leucine can be used in cases where conservation of the size of mutated residues is desired. Alanine scanning is a mature technology which has been used for a long period of time. 15 As used herein, the term "epitope cluster" denotes the entirety of epitopes lying in a defined contiguous stretch of an antigen. An epitope cluster can comprise one, two or more epitopes. The epitope clusters that were defined - in the context of the present invention - in the extracellular domain of BCMA are described above and depicted in Figure 1. 20 The terms "(capable of) binding to", "specifically recognizing", "directed to" and "reacting with" mean in accordance with this invention that a binding domain is capable of specifically interacting with one or more, preferably at least two, more preferably at least three and most preferably at least four amino acids of an epitope. 25 As used herein, the terms "specifically interacting", "specifically binding" or "specifically bind(s)" mean that a binding domain exhibits appreciable affinity for a particular protein or antigen and, generally, does not exhibit significant reactivity with proteins or antigens other than BCMA or CD3. "Appreciable affinity" includes binding with an affinity of about 10-"M (KD) or stronger. Preferably, binding is considered specific when binding affinity is about 10-12 to 10-8 M, 1012 to 30 10-9 M, 10-12 to 10-1 M, 10~1 to 10-8 M, preferably of about 1011 to 10-9 M. Whether a binding domain specifically reacts with or binds to a target can be tested readily by, inter alia, comparing the reaction of said binding domain with a target protein or antigen with the reaction of said binding domain with proteins or antigens other than BCMA or CD3. Preferably, a binding domain of the invention does not essentially bind or is not capable of binding to proteins or 35 antigens other than BCMA or CD3 (i.e. the first binding domain is not capable of binding to 9 proteins other than BCMA and the second binding domain is not capable of binding to proteins other than CD3). The term "does not essentially bind", or "is not capable of binding" means that a binding domain of the present invention does not bind another protein or antigen other than BCMA or CD3, i.e., 5 does not show reactivity of more than 30%, preferably not more than 20%, more preferably not more than 10%, particularly preferably not more than 9%, 8%, 7%, 6% or 5% with proteins or antigens other than BCMA or CD3, whereby binding to BCMA or CD3, respectively, is set to be 100%. 10 Specific binding is believed to be effected by specific motifs in the amino acid sequence of the binding domain and the antigen. Thus, binding is achieved as a result of their primary, secondary and/or tertiary structure as well as the result of secondary modifications of said structures. The specific interaction of the antigen-interaction-site with its specific antigen may result in a simple binding of said site to the antigen. Moreover, the specific interaction of the 15 antigen-interaction-site with its specific antigen may alternatively or additionally result in the initiation of a signal, e.g. due to the induction of a change of the conformation of the antigen, an oligomerization of the antigen, etc. In one aspect, the first binding domain of the present invention binds to epitope cluster 3 of 20 human BCMA and is further capable of binding to epitope cluster 3 of macaque BCMA such as BCMA from Macaca mulatta (SEQ ID NO:1017) or Macaca fascicularis (SEQ ID NO:1017). It is envisaged that the first binding domain does or does not bind to murine BCMA. Accordingly, in one embodiment, a binding domain which binds to human BCMA, in particular to 25 epitope cluster 3 of the extracellular protein domain of BCMA formed by amino acid residues 24 to 41 of the human sequence as depicted in SEQ ID NO: 1002, also binds to macaque BCMA, in particular to epitope cluster 3 of the extracellular protein domain of BCMA formed by amino acid residues 24 to 41 of the macaque BCMA sequence as depicted in SEQ ID NO: 1006. 30 In one embodiment, a first binding domain of a binding molecule is capable of binding to epitope cluster 3 of BCMA, wherein epitope cluster 3 of BCMA corresponds to amino acid residues 24 to 41 of the sequence as depicted in SEQ ID NO: 1002 (human BCMA full-length polypeptide) or SEQ ID NO: 1007 (human BCMA extracellular domain: amino acids 1-54 of SEQ ID NO: 1002). 35 10 In one aspect of the present invention, the first binding domain of the binding molecule is additionally or alternatively capable of binding to epitope cluster 3 of Callithn'x jacchus, Saguinus oedipus and/or Saimiri sciureus BCMA. 5 Proteins (including fragments thereof, preferably biologically active fragments, and peptides, usually having less than 30 amino acids) comprise one or more amino acids coupled to each other via a covalent peptide bond (resulting in a chain of amino acids). The term "polypeptide" as used herein describes a group of molecules, which consist of more than 30 amino acids. Polypeptides may further form multimers such as dimers, trimers and higher oligomers, i.e. 10 consisting of more than one polypeptide molecule. Polypeptide molecules forming such dimers, trimers etc. may be identical or non-identical. The corresponding higher order structures of such multimers are, consequently, termed homo- or heterodimers, homo- or heterotrimers etc. An example for a hereteromultimer is an antibody molecule, which, in its naturally occurring form, consists of two identical light polypeptide chains and two identical heavy polypeptide chains. 15 The terms "polypeptide" and "protein" also refer to naturally modified polypeptides/proteins wherein the modification is effected e.g. by post-translational modifications like glycosylation, acetylation, phosphorylation and the like. A "polypeptide" when referred to herein may also be chemically modified such as pegylated. Such modifications are well known in the art. In another aspect of the invention, the second binding domain is capable of binding to CD3 20 epsilon. In still another aspect of the invention, the second binding domain is capable of binding to human CD3 and to macaque CD3, preferably to human CD3 epsilon and to macaque CD3 epsilon. Additionally or alternatively, the second binding domain is capable of binding to Callithrix jacchus, Saguinus oedipus and/or Saimin' sciureus CD3 epsilon. According to these embodiments, one or both binding domains of the binding molecule of the invention are 25 preferably cross-species specific for members of the mammalian order of primates. Cross species specific CD3 binding domains are, for example, described in WO 2008/119567. It is particularly preferred for the binding molecule of the present invention that the second binding domain capable of binding to the T cell CD3 receptor complex comprises a VL region 30 comprising CDR-L1, CDR-L2 and CDR-L3 selected from: (a) CDR-L1 as depicted in SEQ ID NO: 27 of WO 2008/119567, CDR-L2 as depicted in SEQ ID NO: 28 of WO 2008/119567 and CDR-L3 as depicted in SEQ ID NO: 29 of WO 2008/119567; 11 (b) CDR-L1 as depicted in SEQ ID NO: 117 of WO 2008/119567, CDR-L2 as depicted in SEQ ID NO: 118 of WO 2008/119567 and CDR-L3 as depicted in SEQ ID NO: 119 of WO 2008/119567; and (c) CDR-L1 as depicted in SEQ ID NO: 153 of WO 2008/119567, CDR-L2 as depicted in 5 SEQ ID NO: 154 of WO 2008/119567 and CDR-L3 as depicted in SEQ ID NO: 155 of WO 2008/119567. In an alternatively preferred embodiment of the binding molecule of the present invention, the second binding domain capable of binding to the T cell CD3 receptor complex comprises a VH 10 region comprising CDR-H 1, CDR-H2 and CDR-H3 selected from: (a) CDR-H1 as depicted in SEQ ID NO: 12 of WO 2008/119567, CDR-H2 as depicted in SEQ ID NO: 13 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 14 of WO 2008/119567; (b) CDR-H1 as depicted in SEQ ID NO: 30 of WO 2008/119567, CDR-H2 as depicted in 15 SEQ ID NO: 31 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 32 of WO 2008/119567; (c) CDR-H1 as depicted in SEQ ID NO: 48 of WO 2008/119567, CDR-H2 as depicted in SEQ ID NO: 49 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 50 of WO 2008/119567; 20 (d) CDR-H1 as depicted in SEQ ID NO: 66 of WO 2008/119567, CDR-H2 as depicted in SEQ ID NO: 67 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 68 of WO 2008/119567; (e) CDR-H1 as depicted in SEQ ID NO: 84 of WO 2008/119567, CDR-H2 as depicted in SEQ ID NO: 85 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 86 of 25 WO 2008/119567; (f) CDR-H1 as depicted in SEQ ID NO: 102 of WO 2008/119567, CDR-H2 as depicted in SEQ ID NO: 103 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 104 of WO 2008/119567; (g) CDR-H1 as depicted in SEQ ID NO: 120 of WO 2008/119567, CDR-H2 as depicted in 30 SEQ ID NO: 121 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 122 of WO 2008/119567; (h) CDR-H1 as depicted in SEQ ID NO: 138 of WO 2008/119567, CDR-H2 as depicted in SEQ ID NO: 139 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 140 of WO 2008/119567; 12 (i) CDR-H1 as depicted in SEQ ID NO: 156 of WO 2008/119567, CDR-H2 as depicted in SEQ ID NO: 157 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 158 of WO 2008/119567; and (j) CDR-H1 as depicted in SEQ ID NO: 174 of WO 2008/119567, CDR-H2 as depicted in 5 SEQ ID NO: 175 of WO 2008/119567 and CDR-H3 as depicted in SEQ ID NO: 176 of WO 2008/119567. It is further preferred for the binding molecule of the present invention that the second binding domain capable of binding to the T cell CD3 receptor complex comprises a VL region selected 10 from the group consisting of a VL region as depicted in SEQ ID NO: 35, 39, 125, 129, 161 or 165 of WO 2008/119567. It is alternatively preferred that the second binding domain capable of binding to the T cell CD3 receptor complex comprises a VH region selected from the group consisting of a VH region as 15 depicted in SEQ ID NO: 15, 19, 33, 37, 51, 55, 69, 73, 87, 91, 105, 109, 123, 127, 141, 145, 159, 163, 177 or 181 of WO 2008/119567. More preferably, the binding molecule of the present invention is characterized by the second binding domain capable of binding to the T cell CD3 receptor complex comprising a VL region 20 and a VH region selected from the group consisting of: (a) a VL region as depicted in SEQ ID NO: 17 or 21 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 15 or 19 of WO 2008/119567; (b) a VL region as depicted in SEQ ID NO: 35 or 39 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 33 or 37 of WO 2008/119567; 25 (c) a VL region as depicted in SEQ ID NO: 53 or 57 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 51 or 55 of WO 2008/119567; (d) a VL region as depicted in SEQ ID NO: 71 or 75 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 69 or 73 of WO 2008/119567; (e) a VL region as depicted in SEQ ID NO: 89 or 93 of WO 2008/119567 and a VH region 30 as depicted in SEQ ID NO: 87 or 91 of WO 2008/119567; (f) a VL region as depicted in SEQ ID NO: 107 or 111 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 105 or 109 of WO 2008/119567; (g) a VL region as depicted in SEQ ID NO: 125 or 129 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 123 or 127 of WO 2008/119567; 13 (h) a VL region as depicted in SEQ ID NO: 143 or 147 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 141 or 145 of WO 2008/119567; (i) a VL region as depicted in SEQ ID NO: 161 or 165 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 159 or 163 of WO 2008/119567; and 5 (j) a VL region as depicted in SEQ ID NO: 179 or 183 of WO 2008/119567 and a VH region as depicted in SEQ ID NO: 177 or 181 of WO 2008/119567. According to a preferred embodiment of the binding molecule of the present invention, in particular the second binding domain capable of binding to the T cell CD3 receptor complex, the 10 pairs of VH-regions and VL-regions are in the format of a single chain antibody (scFv). The VH and VL regions are arranged in the order VH-VL or VL-VH. It is preferred that the VH-region is positioned N-terminally to a linker sequence. The VL-region is positioned C-terminally of the linker sequence. 15 A preferred embodiment of the above described binding molecule of the present invention is characterized by the second binding domain capable of binding to the T cell CD3 receptor complex comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 23, 25, 41, 43, 59, 61, 77, 79, 95, 97, 113, 115, 131, 133, 149, 151, 167, 169, 185 or 187 of WO 2008/119567. 20 The affinity of the first binding domain for human BCMA is preferably 515 nM, more preferably 510 nM, even more preferably 55 nM, even more preferably 51 nM, even more preferably 50.5 nM, even more preferably 50.1 nM, and most preferably 50.05 nM. The affinity of the first binding domain for macaque BCMA is preferably 515 nM, more preferably 510 nM, even more 25 preferably 55 nM, even more preferably 51 nM, even more preferably 50.5 nM, even more preferably 50.1 nM, and most preferably 50.05 nM or even 50.01 nM. The affinity can be measured for example in a Biacore assay or in a Scatchard assay, e.g. as described in the Examples. The affinity gap for binding to macaque BCMA versus human BCMA is preferably [1:10-1:5] or [5:1-10:1], more preferably [1:5-5:1], and most preferably [1:2-3:1] or even [1:1 30 3:1]. Other methods of determining the affinity are well-known to the skilled person. Cytotoxicity mediated by BCMA/CD3 bispecific binding molecules can be measured in various ways. Effector cells can be e.g. stimulated enriched (human) CD8 positive T cells or unstimulated (human) peripheral blood mononuclear cells (PBMC). If the target cells are of 35 macaque origin or express or are transfected with macaque BCMA, the effector cells should 14 also be of macaque origin such as a macaque T cell line, e.g. 4119LnPx. The target cells should express (at least the extracellular domain of) BCMA, e.g. human or macaque BCMA. Target cells can be a cell line (such as CHO) which is stably or transiently transfected with BCMA, e.g. human or macaque BCMA. Alternatively, the target cells can be a BCMA positive 5 natural expresser cell line, such as the human multiple myeloma cell line L363 or NCI-H929. Usually EC50-values are expected to be lower with target cell lines expressing higher levels of BCMA on the cell surface. The effector to target cell (E:T) ratio is usually about 10:1, but can also vary. Cytotoxic activity of BCMA/CD3 bispecific binding molecules can be measured in an 51-chromium release assay (incubation time of about 18 hours) or in a in a FACS-based 10 cytotoxicity assay (incubation time of about 48 hours). Modifications of the assay incubation time (cytotoxic reaction) are also possible. Other methods of measuring cytotoxicity are well known to the skilled person and comprise MTT or MTS assays, ATP-based assays including bioluminescent assays, the sulforhodamine B (SRB) assay, WST assay, clonogenic assay and the ECIS technology. 15 The cytotoxic activity mediated by BCMA/CD3 bispecific binding molecules of the present invention is preferably measured in a cell-based cytotoxicity assay. It is represented by the EC 50 value, which corresponds to the half maximal effective concentration (concentration of the binding molecule which induces a cytotoxic response halfway between the baseline and 20 maximum). Preferably, the EC 50 value of the BCMA/CD3 bispecific binding molecules is 520.000 pg/ml, more preferably s5000 pg/ml, even more preferably s1000 pg/ml, even more preferably 5500 pg/ml, even more preferably 5350 pg/mi, even more preferably 5320 pg/ml, even more preferably s250 pg/ml, even more preferably 5100 pg/ml, even more preferably 550 pg/ml, even more preferably 510 pg/ml, and most preferably 55 pg/ml. 25 Any of the above given EC 50 values can be combined with any one of the indicated scenarios of a cell-based cytotoxicity assay. For example, when (human) CD8 positive T cells or a macaque T cell line are used as effector cells, the EC 50 value of the BCMA/CD3 bispecific binding molecule is preferably 51000 pg/ml, more preferably 5500 pg/ml, even more preferably 30 s250 pg/ml, even more preferably s100 pg/ml, even more preferably 550 pg/ml, even more preferably 510 pg/ml, and most preferably s5 pg/ml. If in this assay the target cells are (human or macaque) BCMA transfected cells such as CHO cells, the EC 50 value of the BCMA/CD3 bispecific binding molecule is preferably 5150 pg/ml, more preferably 5100 pg/ml, even more preferably 550 pg/ml, even more preferably 530 pg/ml, even more preferably 510 pg/ml, and 35 most preferably 55 pg/ml. 15 If the target cells are a BCMA positive natural expresser cell line, then the EC 50 value is preferably S350 pg/ml, more preferably S320 pg/ml, even more preferably 5250 pg/ml, even more preferably s200 pg/ml, even more preferably 5100 pg/ml, even more preferably !150 pg/ml, even more preferably 5100 pg/ml, and most preferably 550 pg/ml, or lower. 5 When (human) PBMCs are used as effector cells, the EC 50 value of the BCMA/CD3 bispecific binding molecule is preferably 51000 pg/ml, more preferably 5750 pg/ml, more preferably 5500 pg/ml, even more preferably s350 pg/ml, even more preferably S320 pg/ml, even more preferably 5250 pg/ml, even more preferably 5100 pg/ml, and most preferably S50 pg/ml, or lower. 10 In a particularly preferred embodiment, the BCMA/CD3 bispecific binding molecules of the present invention are characterized by an EC50 of 5350 pg/ml or less, more preferably 5320 pg/ml or less. In that embodiment the target cells are L363 cells and the effector cells are unstimulated human PBMCs. The skilled person knows how to measure the EC50 value without further ado. Moreover, the specification teaches a specific instruction how to measure the EC50 15 value; see, for example, Example 8.3, below.A suitable protocol is as follows: a) Prepare human peripheral blood mononuclear cells (PBMC) by Ficoll density gradient centrifugation from enriched lymphocyte preparations (buffy coats) b) Optionally wash with Dulbecco's PBS (Gibco) c) Remove remaining erythrocytes from PBMC via incubation with erythrocyte lysis buffer 20 (155 mM NH 4 CI, 10 mM KHCO 3 , 100 pM EDTA) c) Remove platelets via the supernatant upon centrifugation of PBMC at 100 x g d) Deplete CD14* cells and NK cells e) Isolate CD14/CD56 negative cells using, e.g. LS Columns (Miltenyi Biotec, #130-042 401) 25 f) Culture PBMC w/o CD14+/CD56+ cells, e.g. in RPMI complete medium i.e. RPM11640 (Biochrom AG, #FG1215) supplemented with 10% FBS (Biochrom AG, #S0115), lx non essential amino acids (Biochrom AG, #K0293), 10 mM Hepes buffer (Biochrom AG, #L1613), 1 mM sodium pyruvate (Biochrom AG, #L0473) and 100 U/mL penicillin/streptomycin (Biochrom AG, #A2213) at 37 0 C in an incubator until needed. 30 g) Label target cells h) Mix effector and target cells, preferably at equal volumes, so as to have an E:T cell ratio of 10:1 i) Add the binding molecule, preferably in a serial dilution j) Proceed for 48 hours in a 7% CO 2 humidified incubator 16 k) Monitor target cell membrane integrity, e.g., by adding propidium iodide (PI) at a final concentration of 1 pg/mL, for example, by flow cytometry I) Calculate EC50, e.g., according to the following formula: Cytotoxicity [%] = dead target cells x 100 target cells 5 n = number of events Using GraphPad Prism 5 software (Graph Pad Software, San Diego), the percentage of cytotoxicity was plotted against the corresponding bispecific antibody concentrations. Dose response curves can be analyzed with the four parametric logistic regression models for evaluation of sigmoid dose response curves with fixed hill slope and EC50 values were 10 calculated. In view of the above, it is preferred that the binding molecule of the present invention is characterized by an EC50 (pg/ml) of 350 or less, preferably 320 or less. 15 The present invention also relates to binding molecules described herein which are characterized by an EC50 (pg/ml) which equates to the EC50 (pg/ml) of any one of the BCMA/CD3 bispecific binding molecules BCMA-83 x CD3, BCMA-62 x CD3, BCMA-5 x CD3, BCMA-98 x CD3, BCMA-71 x CD3, BCMA-34 x CD3, BCMA-74 x CD3, BCMA-20 x CD3. In order to determine as to whether the EC50 of a binding molecule as described herein equates 20 to the EC50 of any one of BCMA-83 x CD3, BCMA-62 x CD3, BCMA-5 x CD3, BCMA 98 x CD3, BCMA-71 x CD3, BCMA-34 x CD3, BCMA-74 x CD3, BCMA-20 x CD3, it is envisaged that for the determination of the EC50 value the same assay is applied. The term "equates to" includes thereby a deviation of +/- 10%, preferably +/- 7.5%, more preferably +/ 5%, even more preferably +/- 2.5% of the respective EC50 value. 25 The BCMA/CD3 bispecific binding molecules BCMA-83 x CD3, BCMA-62 x CD3, BCMA 5 x CD3, BCMA-98 x CD3, BCMA-71 x CD3, BCMA-34 x CD3, BCMA-74 x CD3, BCMA 20 x CD3 that serve as "reference" binding molecules in the above described assay are preferably produced in CHO cells. 30 The difference in cytotoxic activity between the monomeric and the dimeric isoform of individual BCMA/CD3 bispecific binding molecules (such as antibodies) is referred to as "potency gap". This potency gap can e.g. be calculated as ratio between EC 50 values of the molecule's monomeric and dimeric form. Potency gaps of the BCMA/CD3 bispecific binding molecules of 17 the present invention are preferably 55, more preferably 54, even more preferably s3, even more preferably 2 and most preferably s1. Preferably, the BCMA/CD3 bispecific binding molecules of the present invention do not bind to, 5 interact with, recognize or cross-react with human BAFF-R and/or human TACI. Methods to detect cross-reactivity with human BAFF-R and/or human TACI are disclosed in Example 9. It is also preferred that the BCMA/CD3 bispecific binding molecules of the present invention present with very low dimer conversion after a number of freeze/thaw cycles. Preferably the 10 dimer percentages are 55%, more preferably 54%, even more preferably 53%, even more preferably s2.5%, even more preferably s2%, even more preferably s1.5%, and most preferably 51%, for example after three freeze/thaw cycles. A freeze-thaw cycle and the determination of the dimer percentage can be carried out in accordance with Example 16. 15 The BCMA/CD3 bispecific binding molecules (such as antibodies) of the present invention preferably show a favorable thermostability with melting temperatures above 60 0 C. To determine potential interaction of BCMA/CD3 bispecific binding molecules (such as antibodies) with human plasma proteins, a plasma interference test can be carried out (see e.g. 20 Example 18). In a preferred embodiment, there is no significant reduction of target binding of the BCMA/CD3 bispecific binding molecules mediated by plasma proteins. The relative plasma interference value is preferably 2. It is furthermore envisaged that the BCMA/CD3 bispecific binding molecules of the present 25 invention are capable of exhibiting therapeutic efficacy or anti-tumor activity. This can be assessed e.g. in a study as disclosed in Example 19 (advanced stage human tumor xenograft model). The skilled person knows how to modify or adapt certain parameters of this study, such as the number of injected tumor cells, the site of injection, the number of transplanted human T cells, the amount of BCMA/CD3 bispecific binding molecules to be administered, and the 30 timelines, while still arriving at a meaningful and reproducible result. Preferably, the tumor growth inhibition T/C [%] is 70 or 60 or lower, more preferably 50 or 40 or lower, even more preferably at least 30 or 20 or lower and most preferably 10 or lower, 5 or lower or even 2.5 or lower. 18 Preferably, the BCMA/CD3 bispecific binding molecules of the present invention do not induce / mediate lysis or do not essentially induce / mediate lysis of BCMA negative cells such as HL60, MES-SA, and SNU-16. The term "do not induce lysis", "do not essentially induce lysis", "do not mediate lysis" or "do not essentially mediate lysis" means that a binding molecule of the present 5 invention does not induce or mediate lysis of more than 30%, preferably not more than 20%, more preferably not more than 10%, particularly preferably not more than 9%, 8%, 7%, 6% or 5% of BCMA negative cells, whereby lysis of a BCMA positive cell line such as NCI-H929, L 363 or OPM-2 is set to be 100%. This applies for concentrations of the binding molecule of at least up to 500 nM. The skilled person knows how to measure cell lysis without further ado. 10 Moreover, the specification teaches a specific instruction how to measure cell lysis; see e.g. Example 20 below. In one embodiment, the first or the second binding domain is or is derived from an antibody. In another embodiment, both binding domains are or are derived from an antibody. 15 The definition of the term "antibody" includes embodiments such as monoclonal, chimeric, single chain, humanized and human antibodies. In addition to full-length antibodies, the definition also includes antibody derivatives and antibody fragments, like, inter alia, Fab fragments. Antibody fragments or derivatives further comprise F(ab') 2 , Fv, scFv fragments or 20 single domain antibodies such as domain antibodies or nanobodies, single variable domain antibodies or immunoglobulin single variable domain comprising merely one variable domain, which might be VHH, VH or VL, that specifically bind an antigen or epitope independently of other V regions or domains; see, for example, Harlow and Lane (1988) and (1999), loc. cit.; Kontermann and DObel, Antibody Engineering, Springer, 2nd ed. 2010 and Little, Recombinant 25 Antibodies for Immunotherapy, Cambridge University Press 2009. Said term also includes diabodies or Dual-Affinity Re-Targeting (DART) antibodies. Further envisaged are (bispecific) single chain diabodies, tandem diabodies (Tandab's), ,,minibodies" exemplified by a structure which is as follows: (VH-VL-CH3) 2 , (scFv-CH3) 2 or (scFv-CH3-scFv) 2 , ,,Fc DART" antibodies and ,lgG DART" antibodies, and multibodies such as triabodies. Immunoglobulin single variable 30 domains encompass not only an isolated antibody single variable domain polypeptide, but also larger polypeptides that comprise one or more monomers of an antibody single variable domain polypeptide sequence. Various procedures are known in the art and may be used for the production of such antibodies 35 and/or fragments. Thus, (antibody) derivatives can be produced by peptidomimetics. Further, 19 techniques described for the production of single chain antibodies (see, inter alia, US Patent 4,946,778, Kontermann and Dubel (2010), loc. cit. and Little (2009), loc. cit.) can be adapted to produce single chain antibodies specific for elected polypeptide(s). Also, transgenic animals may be used to express humanized antibodies specific for polypeptides and fusion proteins of 5 this invention. For the preparation of monoclonal antibodies, any technique, providing antibodies produced by continuous cell line cultures can be used. Examples for such techniques include the hybridoma technique (K6hler and Milstein Nature 256 (1975), 495-497), the trioma technique, the human B cell hybridoma technique (Kozbor, Immunology Today 4 (1983), 72) and the EBV hybridoma technique to produce human monoclonal antibodies (Cole et al., 10 Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc. (1985), 77-96). Surface plasmon resonance as employed in the BlAcore system can be used to increase the efficiency of phage antibodies which bind to an epitope of a target polypeptide, such as CD3 epsilon (Schier, Human Antibodies Hybridomas 7 (1996), 97-105; Malmborg, J. Immunol. Methods 183 (1995), 7-13). It is also envisaged in the context of this invention that the term "antibody" comprises 15 antibody constructs, which may be expressed in a host as described herein below, e.g. antibody constructs which may be transfected and/or transduced via, inter alia, viruses or plasmid vectors. Furthermore, the term "antibody" as employed herein also relates to derivatives or variants of 20 the antibodies described herein which display the same specificity as the described antibodies. Examples of "antibody variants" include humanized variants of non-human antibodies, "affinity matured" antibodies (see, e.g. Hawkins et al. J. Mol. Biol. 254, 889-896 (1992) and Lowman et al., Biochemistry 30, 10832- 10837 (1991)) and antibody mutants with altered effector function(s) (see, e.g., US Patent 5, 648, 260, Kontermann and Dubel (2010), loc. cit. and 25 Little(2009), loc. cit.). The terms "antigen-binding domain", "antigen-binding fragment" and "antibody binding region" when used herein refer to a part of an antibody molecule that comprises amino acids responsible for the specific binding between antibody and antigen. The part of the antigen that 30 is specifically recognized and bound by the antibody is referred to as the "epitope" as described herein above. As mentioned above, an antigen-binding domain may typically comprise an antibody light chain variable region (VL) and an antibody heavy chain variable region (VH); however, it does not have to comprise both. Fd fragments, for example, have two VH regions and often retain some antigen-binding function of the intact antigen-binding domain. Examples 35 of antigen-binding fragments of an antibody include (1) a Fab fragment, a monovalent fragment 20 having the VL, VH, CL and CH1 domains; (2) a F(ab')2 fragment, a bivalent fragment having two Fab fragments linked by a disulfide bridge at the hinge region; (3) an Fd fragment having the two VH and CH1 domains; (4) an Fv fragment having the VL and VH domains of a single arm of an antibody, (5) a dAb fragment (Ward et al., (1989) Nature 341 :544-546), which has a 5 VH domain; (6) an isolated complementarity determining region (CDR), and (7) a single chain Fv (scFv), the latter being preferred (for example, derived from a scFV-library). Although the two domains of the Fv fragment, VL and VH are coded for by separate genes, they can be joined, using recombinant methods, by a synthetic linker that enables them to be made as a single protein chain in which the VL and VH regions pair to form monovalent molecules (known as 10 single chain Fv (scFv); see e.g., Huston et al. (1988) Proc. NatI. Acad. Sci USA 85:5879-5883). These antibody fragments are obtained using conventional techniques known to those with skill in the art, and the fragments are evaluated for function in the same manner as are intact antibodies. 15 The term "monoclonal antibody" as used herein refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally occurring mutations and/or post- translation modifications (e.g., isomerizations, amidations) that may be present in minor amounts. Monoclonal antibodies are highly specific, being directed against a single antigenic site. 20 Furthermore, in contrast to conventional (polyclonal) antibody preparations which typically include different antibodies directed against different determinants (epitopes), each monoclonal antibody is directed against a single determinant on the antigen. In addition to their specificity, the monoclonal antibodies are advantageous in that they are synthesized by the hybridoma culture, uncontaminated by other immunoglobulins. The modifier "monoclonal" indicates the 25 character of the antibody as being obtained from a substantially homogeneous population of antibodies, and is not to be construed as requiring production of the antibody by any particular method. For example, the monoclonal antibodies to be used in accordance with the present invention may be made by the hybridoma method first described by Kohler et al., Nature, 256: 495 (1975), or may be made by recombinant DNA methods (see, e.g., U. S. Patent 30 No. 4,816,567). The "monoclonal antibodies" may also be isolated from phage antibody libraries using the techniques described in Clackson et al., Nature, 352: 624-628 (1991) and Marks et al., J. Mol. Biol., 222: 581-597 (1991), for example. The monoclonal antibodies of the present invention specifically include "chimeric" antibodies 35 (immunoglobulins) in which a portion of the heavy and/or light chain is identical with or 21 homologous to corresponding sequences in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the chain (s) is (are) identical with or homologous to corresponding sequences in antibodies derived from another species or belonging to another antibody class or subclass, as well as fragments of such 5 antibodies, so long as they exhibit the desired biological activity (U. S. Patent No. 4,816, 567; Morrison et al., Proc. NatI. Acad. Sci. USA, 81: 6851-6855 (1984)). Chimeric antibodies of interest herein include "primitized" antibodies comprising variable domain antigen-binding sequences derived from a non-human primate (e.g., Old World Monkey, Ape etc.) and human constant region sequences. 10 "Humanized" forms of non-human (e.g., murine) antibodies are chimeric immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab', F(ab')2 or other antigen binding subsequences of antibodies) of mostly human sequences, which contain minimal sequence derived from non-human immunoglobulin. For the most part, humanized antibodies 15 are human immunoglobulins (recipient antibody) in which residues from a hypervariable region (also CDR) of the recipient are replaced by residues from a hypervariable region of a non human species (donor antibody) such as mouse, rat or rabbit having the desired specificity, affinity, and capacity. In some instances, Fv framework region (FR) residues of the human immunoglobulin are replaced by corresponding non-human residues. Furthermore, "humanized 20 antibodies" as used herein may also comprise residues which are found neither in the recipient antibody nor the donor antibody. These modifications are made to further refine and optimize antibody performance. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin. For further details, see Jones et al., Nature, 321: 522-525 (1986); Reichmann et al., Nature, 332: 323-329 25 (1988); and Presta, Curr. Op. Struct. Biol., 2: 593-596 (1992). The term "human antibody" includes antibodies having variable and constant regions corresponding substantially to human germline immunoglobulin sequences known in the art, including, for example, those described by Kabat et al. (See Kabat et al. (1991) loc. cit.). The 30 human antibodies of the invention may include amino acid residues not encoded by human germline immunoglobulin sequences (e.g., mutations introduced by random or site-specific mutagenesis in vitro or by somatic mutation in vivo), for example in the CDRs, and in particular, CDR3. The human antibody can have at least one, two, three, four, five, or more positions replaced with an amino acid residue that is not encoded by the human germline immunoglobulin 35 sequence. 22 As used herein, "in vitro generated antibody" refers to an antibody where all or part of the variable region (e.g., at least one CDR) is generated in a non-immune cell selection (e.g., an in vitro phage display, protein chip or any other method in which candidate sequences can be 5 tested for their ability to bind to an antigen). This term thus preferably excludes sequences generated by genomic rearrangement in an immune cell. A "bispecific" or "bifunctional" antibody or immunoglobulin is an artificial hybrid antibody or immunoglobulin having two different heavy/light chain pairs and two different binding sites. 10 Bispecific antibodies can be produced by a variety of methods including fusion of hybridomas or linking of Fab' fragments. See, e.g., Songsivilai & Lachmann, Clin. Exp. Immunol. 79:315-321 (1990). Numerous methods known to those skilled in the art are available for obtaining antibodies or antigen-binding fragments thereof. For example, antibodies can be produced using recombinant DNA methods (U.S. Patent No. 4,816,567). Monoclonal antibodies may also 15 be produced by generation of hybridomas (see e.g., Kohler and Milstein (1975) Nature, 256: 495-499) in accordance with known methods. Hybridomas formed in this manner are then screened using standard methods, such as enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (BIACORETM) analysis, to identify one or more hybridomas that produce an antibody that specifically binds with a specified antigen. Any form of the specified 20 antigen may be used as the immunogen, e.g., recombinant antigen, naturally occurring forms, any variants or fragments thereof, as well as antigenic peptide thereof." One exemplary method of making antibodies includes screening protein expression libraries, e.g., phage or ribosome display libraries. Phage display is described, for example, in Ladner et 25 al., U.S. Patent No. 5,223,409; Smith (1985) Science 228:1315-1317; Clackson et al. (1991) Nature, 352: 624-628. In addition to the use of display libraries, the specified antigen can be used to immunize a non human animal, e.g., a rodent, e.g., a mouse, hamster, or rat. In one embodiment, the non human animal includes at least a part of a human immunoglobulin gene. For example, it is 30 possible to engineer mouse strains deficient in mouse antibody production with large fragments of the human Ig loci. Using the hybridoma technology, antigen-specific monoclonal antibodies derived from the genes with the desired specificity may be produced and selected. See, e.g., XENOMOUSE T M , Green et al. (1994) Nature Genetics 7:13-21, US 2003- 0070185, WO 96/34096, and WO96/33735. 35 23 A monoclonal antibody can be obtained from a non-human animal, and then modified, e.g., humanized, deimmunized, chimeric, may be produced using recombinant DNA techniques known in the art. A variety of approaches for making chimeric antibodies have been described. See e.g., Morrison et al., Proc. Nati. Acad. ScL U.S.A. 81:6851 , 1985; Takeda etal., Nature 5 314:452, 1985, Cabilly et al., U.S. Patent No. 4,816,567; Boss et al., U.S. Patent No. 4,816,397; Tanaguchi et al., EP 0171496; EP 0173494, GB 2177096. Humanized antibodies may also be produced, for example, using transgenic mice that express human heavy and light chain genes, but are incapable of expressing the endogenous mouse immunoglobulin heavy and light chain genes. Winter describes an exemplary CDR-grafting method that may be used to prepare the 10 humanized antibodies described herein (U.S. Patent No. 5,225,539). All of the CDRs of a particular human antibody may be replaced with at least a portion of a non-human CDR, or only some of the CDRs may be replaced with non-human CDRs. It is only necessary to replace the number of CDRs required for binding of the humanized antibody to a predetermined antigen. 15 Humanized antibodies or fragments thereof can be generated by replacing sequences of the Fv variable domain that are not directly involved in antigen binding with equivalent sequences from human Fv variable domains. Exemplary methods for generating humanized antibodies or fragments thereof are provided by Morrison (1985) Science 229:1202-1207; by Oi et al. (1986) BioTechniques 4:214; and by US 5,585,089; US 5,693,761; US 5,693,762; US 5,859,205; and 20 US 6,407,213. Those methods include isolating, manipulating, and expressing the nucleic acid sequences that encode all or part of immunoglobulin Fv variable domains from at least one of a heavy or light chain. Such nucleic acids may be obtained from a hybridoma producing an antibody against a predetermined target, as described above, as well as from other sources. The recombinant DNA encoding the humanized antibody molecule can then be cloned into an 25 appropriate expression vector. A humanized antibody can be optimized by the introduction of conservative substitutions, consensus sequence substitutions, germline substitutions and/or back mutations. Such altered immunoglobulin molecules can be made by any of several techniques known in the art, (e.g., 30 Teng et al., Proc. NatI. Acad. Sci. U.S.A., 80: 7308-7312, 1983; Kozbor et al., Immunology Today, 4: 7279, 1983; Olsson et al., Meth. Enzymol., 92: 3-16, 1982), and may be made according to the teachings of EP 239 400. An antibody or fragment thereof may also be modified by specific deletion of human T cell epitopes or "deimmunization" by the methods disclosed in WO 98/52976 and WO 00/34317. 35 Briefly, the heavy and light chain variable domains of an antibody can be analyzed for peptides 24 that bind to MHC class 1l; these peptides represent potential T cell epitopes (as defined in WO 98/52976 and WO 00/34317). For detection of potential T cell epitopes, a computer modeling approach termed "peptide threading" can be applied, and in addition a database of human MHC class 11 binding peptides can be searched for motifs present in the VH and VL 5 sequences, as described in WO 98/52976 and WO 00/34317. These motifs bind to any of the 18 major MHC class 11 DR allotypes, and thus constitute potential T cell epitopes. Potential T cell epitopes detected can be eliminated by substituting small numbers of amino acid residues in the variable domains, or preferably, by single amino acid substitutions. Typically, conservative substitutions are made. Often, but not exclusively, an amino acid common to a 10 position in human germline antibody sequences may be used. Human germline sequences, e.g., are disclosed in Tomlinson, et al. (1992) J. Mol. Biol. 227:776-798; Cook, G.P. et al. (1995) Immunol. Today Vol. 16 (5): 237-242; and Tomlinson et al. (1995) EMBO J. 14: 14:4628-4638. The V BASE directory provides a comprehensive directory of human immunoglobulin variable region sequences (compiled by Tomlinson, LA. et al. MRC Centre for Protein Engineering, 15 Cambridge, UK). These sequences can be used as a source of human sequence, e.g., for framework regions and CDRs. Consensus human framework regions can also be used, e.g., as described in US Patent No. 6,300,064. The pairing of a VH and VL together forms a single antigen-binding site. The CH domain most 20 proximal to VH is designated as CH1. Each L chain is linked to an H chain by one covalent disulfide bond, while the two H chains are linked to each other by one or more disulfide bonds depending on the H chain isotype. The VH and VL domains consist of four regions of relatively conserved sequences called framework regions (FR1, FR2, FR3, and FR4), which form a scaffold for three regions of hypervariable sequences (complementarity determining regions, 25 CDRs). The CDRs contain most of the residues responsible for specific interactions of the antibody with the antigen. CDRs are referred to as CDR 1, CDR2, and CDR3. Accordingly, CDR constituents on the heavy chain are referred to as H1, H2, and H3, while CDR constituents on the light chain are referred to as L1, L2, and L3. The term "variable" refers to the portions of the immunoglobulin domains that exhibit variability 30 in their sequence and that are involved in determining the specificity and binding affinity of a particular antibody (i.e., the "variable domain(s)"). Variability is not evenly distributed throughout the variable domains of antibodies; it is concentrated in sub-domains of each of the heavy and light chain variable regions. These sub-domains are called "hypervariable" regions or "complementarity determining regions" (CDRs). The more conserved (i.e., non-hypervariable) 35 portions of the variable domains are called the 'framework" regions (FRM). The variable 25 domains of naturally occurring heavy and light chains each comprise four FRM regions, largely adopting a p-sheet configuration, connected by three hypervariable regions, which form loops connecting, and in some cases forming part of, the p-sheet structure. The hypervariable regions in each chain are held together in close proximity by the FRM and, with the hypervariable 5 regions from the other chain, contribute to the formation of the antigen-binding site (see Kabat et al., loc. cit.). The constant domains are not directly involved in antigen binding, but exhibit various effector functions, such as, for example, antibody-dependent, cell-mediated cytotoxicity and complement activation. 10 It is also preferred for the binding molecule of the invention that first and the second domain form a molecule that is selected from the group of (scFv) 2 , (single domain mAb) 2 , scFv-single domain mAb, diabody or oligomeres thereof. The terms "CDR", and its plural "CDRs", refer to a complementarity determining region (CDR) of 15 which three make up the binding character of a light chain variable region (CDRL1, CDRL2 and CDRL3) and three make up the binding character of a heavy chain variable region (CDRH1, CDRH2 and CDRH3). CDRs contribute to the functional activity of an antibody molecule and are separated by amino acid sequences that comprise scaffolding or framework regions. The exact definitional CDR boundaries and lengths are subject to different classification and 20 numbering systems. CDRs may therefore be referred to by Kabat, Chothia, contact or any other boundary definitions, including the numbering system described herein. Despite differing boundaries, each of these systems has some degree of overlap in what constitutes the so called "hypervariable regions" within the variable sequences. CDR definitions according to these systems may therefore differ in length and boundary areas with respect to the adjacent 25 framework region. See for example Kabat, Chothia, and/or MacCallum (Kabat et al., loc. cit.; Chothia et al., J. Mol. Biol, 1987, 196: 901; and MacCallum et al., J. Mol. Biol, 1996, 262: 732). However, the numbering in accordance with the so-called Kabat system is preferred. The term "amino acid" or "amino acid residue" typically refers to an amino acid having its art 30 recognized definition such as an amino acid selected from the group consisting of: alanine (Ala or A); arginine (Arg or R); asparagine (Asn or N); aspartic acid (Asp or D); cysteine (Cys or C); glutamine (GIn or Q); glutamic acid (Glu or E); glycine (Gly or G); histidine (His or H); isoleucine (He or 1): leucine (Leu or L); lysine (Lys or K); methionine (Met or M); phenylalanine (Phe or F); pro line (Pro or P); serine (Ser or S); threonine (Thr or T); tryptophan (Trp or W); tyrosine (Tyr or 35 Y); and valine (Val or V), although modified, synthetic, or rare amino acids may be used as 26 desired. Generally, amino acids can be grouped as having a nonpolar side chain (e.g., Ala, Cys, He, Leu, Met, Phe, Pro, Val); a negatively charged side chain (e.g., Asp, Glu); a positively charged sidechain (e.g., Arg, His, Lys); or an uncharged polar side chain (e.g., Asn, Cys, Gln, Gly, His, Met, Phe, Ser, Thr, Trp, and Tyr). 5 The term "hypervariable region" (also known as "complementarity determining regions" or CDRs) when used herein refers to the amino acid residues of an antibody which are (usually three or four short regions of extreme sequence variability) within the V-region domain of an immunoglobulin which form the antigen-binding site and are the main determinants of antigen 10 specificity. There are at least two methods for identifying the CDR residues: (1) An approach based on cross-species sequence variability (i. e., Kabat et al., loc. cit.); and (2) An approach based on crystallographic studies of antigen-antibody complexes (Chothia, C. et al., J. Mol. Biol. 196: 901-917 (1987)). However, to the extent that two residue identification techniques define regions of overlapping, but not identical regions, they can be combined to define a hybrid CDR. 15 However, in general, the CDR residues are preferably identified in accordance with the so called Kabat (numbering) system. The term "framework region" refers to the art-recognized portions of an antibody variable region that exist between the more divergent (i.e., hypervariable) CDRs. Such framework regions are 20 typically referred to as frameworks 1 through 4 (FR1, FR2, FR3, and FR4) and provide a scaffold for the presentation of the six CDRs (three from the heavy chain and three from the light chain) in three dimensional space, to form an antigen-binding surface. Typically, CDRs form a loop structure that can be classified as a canonical structure. The term 25 "canonical structure" refers to the main chain conformation that is adopted by the antigen binding (CDR) loops. From comparative structural studies, it has been found that five of the six antigen binding loops have only a limited repertoire of available conformations. Each canonical structure can be characterized by the torsion angles of the polypeptide backbone. Correspondent loops between antibodies may, therefore, have very similar three dimensional 30 structures, despite high amino acid sequence variability in most parts of the loops (Chothia and Lesk, J. Mol. Biol., 1987, 196: 901; Chothia et al., Nature, 1989, 342: 877; Martin and Thornton, J. Mol. Biol, 1996, 263: 800, each of which is incorporated by reference in its entirety). Furthermore, there is a relationship between the adopted loop structure and the amino acid sequences surrounding it. The conformation of a particular canonical class is determined by the 35 length of the loop and the amino acid residues residing at key positions within the loop, as well 27 as within the conserved framework (i.e., outside of the loop). Assignment to a particular canonical class can therefore be made based on the presence of these key amino acid residues. The term "canonical structure" may also include considerations as to the linear sequence of the antibody, for example, as catalogued by Kabat (Kabat et al., loc. cit.). The 5 Kabat numbering scheme (system) is a widely adopted standard for numbering the amino acid residues of an antibody variable domain in a consistent manner and is the preferred scheme applied in the present invention as also mentioned elsewhere herein. Additional structural considerations can also be used to determine the canonical structure of an antibody. For example, those differences not fully reflected by Kabat numbering can be described by the 10 numbering system of Chothia et al and/or revealed by other techniques, for example, crystallography and two or three-dimensional computational modeling. Accordingly, a given antibody sequence may be placed into a canonical class which allows for, among other things, identifying appropriate chassis sequences (e.g., based on a desire to include a variety of canonical structures in a library). Kabat numbering of antibody amino acid sequences and 15 structural considerations as described by Chothia et al., loc. cit. and their implications for construing canonical aspects of antibody structure, are described in the literature. CDR3 is typically the greatest source of molecular diversity within the antibody-binding site. H3, for example, can be as short as two amino acid residues or greater than 26 amino acids. The 20 subunit structures and three-dimensional configurations of different classes of immunoglobulins are well known in the art. For a review of the antibody structure, see Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory, eds. Harlow et al., 1988. One of skill in the art will recognize that each subunit structure, e.g., a CH, VH, CL, VL, CDR, FR structure, comprises active fragments, e.g., the portion of the VH, VL, or CDR subunit the binds to the antigen, i.e., 25 the antigen-binding fragment, or, e.g., the portion of the CH subunit that binds to and/or activates, e.g., an Fc receptor and/or complement. The CDRs typically refer to the Kabat CDRs, as described in Sequences of Proteins of immunological Interest, US Department of Health and Human Services (1991), eds. Kabat et al. Another standard for characterizing the antigen binding site is to refer to the hypervariable loops as described by Chothia. See, e.g., Chothia, et 30 al. (1987; J. Mol. Biol. 227:799-817); and Tomlinson et al. (1995) EMBO J. 14: 4628-4638. Still another standard is the AbM definition used by Oxford Molecular's AbM antibody modeling software. See, generally, e.g., Protein Sequence and Structure Analysis of Antibody Variable Domains. In: Antibody Engineering Lab Manual (Ed.: Duebel, S. and Kontermann, R., Springer Verlag, Heidelberg). Embodiments described with respect to Kabat CDRs can alternatively be 28 implemented using similar described relationships with respect to Chothia hypervariable loops or to the AbM-defined loops. The sequence of antibody genes after assembly and somatic mutation is highly varied, and 5 these varied genes are estimated to encode 1010 different antibody molecules (Immunoglobulin Genes, 2 nd ed., eds. Jonio et al., Academic Press, San Diego, CA, 1995). Accordingly, the immune system provides a repertoire of immunoglobulins. The term "repertoire" refers to at least one nucleotide sequence derived wholly or partially from at least one sequence encoding at least one immunoglobulin. The sequence(s) may be generated by rearrangement in vivo of 10 the V, D, and J segments of heavy chains, and the V and J segments of light chains. Alternatively, the sequence(s) can be generated from a cell in response to which rearrangement occurs, e.g., in vitro stimulation. Alternatively, part or all of the sequence(s) may be obtained by DNA splicing, nucleotide synthesis, mutagenesis, and other methods, see, e.g., U.S. Patent 5,565,332. A repertoire may include only one sequence or may include a plurality of sequences, 15 including ones in a genetically diverse collection. In one embodiment, the first binding domain of the binding molecule of the invention comprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 and a VL region comprising CDR-L1, CDR-L2 and CDR-L3 selected from the group consisting of: 20 (1) CDR-H1 as depicted in SEQ ID NO: 1, CDR-H2 as depicted in SEQ ID NO: 2, CDR-H3 as depicted in SEQ ID NO: 3, CDR-L1 as depicted in SEQ ID NO: 4, CDR-L2 as depicted in SEQ ID NO: 5 and CDR-L3 as depicted in SEQ ID NO: 6; (2) CDR-H1 as depicted in SEQ ID NO: 11, CDR-H2 as depicted in SEQ ID NO: 12, CDR H3 as depicted in SEQ ID NO: 13, CDR-L1 as depicted in SEQ ID NO: 14, CDR-L2 as 25 depicted in SEQ ID NO: 15 and CDR-L3 as depicted in SEQ ID NO: 16; (3) CDR-H1 as depicted in SEQ ID NO: 21, CDR-H2 as depicted in SEQ ID NO: 22, CDR H3 as depicted in SEQ ID NO: 23, CDR-L1 as depicted in SEQ ID NO: 24, CDR-L2 as depicted in SEQ ID NO: 25 and CDR-L3 as depicted in SEQ ID NO: 26; (4) CDR-H1 as depicted in SEQ ID NO: 31, CDR-H2 as depicted in SEQ ID NO: 32, CDR 30 H3 as depicted in SEQ ID NO: 33, CDR-L1 as depicted in SEQ ID NO: 34, CDR-L2 as depicted in SEQ ID NO: 35 and CDR-L3 as depicted in SEQ ID NO: 36; (5) CDR-H1 as depicted in SEQ ID NO: 41, CDR-H2 as depicted in SEQ ID NO: 42, CDR H3 as depicted in SEQ ID NO: 43, CDR-L1 as depicted in SEQ ID NO: 44, CDR-L2 as depicted in SEQ ID NO: 45 and CDR-L3 as depicted in SEQ ID NO: 46; 29 (6) CDR-H1 as depicted in SEQ ID NO: 51, CDR-H2 as depicted in SEQ ID NO: 52, CDR H3 as depicted in SEQ ID NO: 53, CDR-L1 as depicted in SEQ ID NO: 54, CDR-L2 as depicted in SEQ ID NO: 55 and CDR-L3 as depicted in SEQ ID NO: 56; (7) CDR-H1 as depicted in SEQ ID NO: 61, CDR-H2 as depicted in SEQ ID NO: 62, CDR 5 H3 as depicted in SEQ ID NO: 63, CDR-L1 as depicted in SEQ ID NO: 64, CDR-L2 as depicted in SEQ ID NO: 65 and CDR-L3 as depicted in SEQ ID NO: 66; (8) CDR-H1 as depicted in SEQ ID NO: 71, CDR-H2 as depicted in SEQ ID NO: 72, CDR H3 as depicted in SEQ ID NO: 73, CDR-L1 as depicted in SEQ ID NO: 74, CDR-L2 as depicted in SEQ ID NO: 75 and CDR-L3 as depicted in SEQ ID NO: 76; 10 (9) CDR-H1 as depicted in SEQ ID NO: 161, CDR-H2 as depicted in SEQ ID NO: 162, CDR-H3 as depicted in SEQ ID NO: 163, CDR-L1 as depicted in SEQ ID NO: 164, CDR L2 as depicted in SEQ ID NO: 165 and CDR-L3 as depicted in SEQ ID NO: 166; (10) CDR-H1 as depicted in SEQ ID NO: 171, CDR-H2 as depicted in SEQ ID NO: 172, CDR-H3 as depicted in SEQ ID NO: 173, CDR-L1 as depicted in SEQ ID NO: 174, CDR 15 L2 as depicted in SEQ ID NO: 175 and CDR-L3 as depicted in SEQ ID NO: 176; (11) CDR-H1 as depicted in SEQ ID NO: 181, CDR-H2 as depicted in SEQ ID NO: 182, CDR-H3 as depicted in SEQ ID NO: 183, CDR-L1 as depicted in SEQ ID NO: 184, CDR L2 as depicted in SEQ ID NO: 185 and CDR-L3 as depicted in SEQ ID NO: 186; (12) CDR-H1 as depicted in SEQ ID NO: 191, CDR-H2 as depicted in SEQ ID NO: 192, 20 CDR-H3 as depicted in SEQ ID NO: 193, CDR-L1 as depicted in SEQ ID NO: 194, CDR L2 as depicted in SEQ ID NO: 195 and CDR-L3 as depicted in SEQ ID NO: 196; (13) CDR-H1 as depicted in SEQ ID NO: 201, CDR-H2 as depicted in SEQ ID NO: 202, CDR-H3 as depicted in SEQ ID NO: 203, CDR-L1 as depicted in SEQ ID NO: 204, CDR L2 as depicted in SEQ ID NO: 205 and CDR-L3 as depicted in SEQ ID NO: 206; 25 (14) CDR-H1 as depicted in SEQ ID NO: 211, CDR-H2 as depicted in SEQ ID NO: 212, CDR-H3 as depicted in SEQ ID NO: 213, CDR-L1 as depicted in SEQ ID NO:214 , CDR L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted in SEQ ID NO: 216; (15) CDR-H1 as depicted in SEQ ID NO: 221, CDR-H2 as depicted in SEQ ID NO: 222, CDR-H3 as depicted in SEQ ID NO: 223, CDR-L1 as depicted in SEQ ID NO: 224, CDR 30 L2 as depicted in SEQ ID NO: 225 and CDR-L3 as depicted in SEQ ID NO: 226; (16) CDR-H1 as depicted in SEQ ID NO: 311, CDR-H2 as depicted in SEQ ID NO: 312, CDR-H3 as depicted in SEQ ID NO: 313, CDR-L1 as depicted in SEQ ID NO: 314, CDR L2 as depicted in SEQ ID NO: 315 and CDR-L3 as depicted in SEQ ID NO: 316; 30 (17) CDR-H1 as depicted in SEQ ID NO: 321, CDR-H2 as depicted in SEQ ID NO: 322, CDR-H3 as depicted in SEQ ID NO: 323, CDR-L1 as depicted in SEQ ID NO: 324, CDR L2 as depicted in SEQ ID NO: 325 and CDR-L3 as depicted in SEQ ID NO: 326; (18) CDR-H1 as depicted in SEQ ID NO: 331, CDR-H2 as depicted in SEQ ID NO: 332, 5 CDR-H3 as depicted in SEQ ID NO: 333, CDR-L1 as depicted in SEQ ID NO: 334, CDR L2 as depicted in SEQ ID NO: 335 and CDR-L3 as depicted in SEQ ID NO: 336; (19) CDR-H1 as depicted in SEQ ID NO: 341, CDR-H2 as depicted in SEQ ID NO: 342, CDR-H3 as depicted in SEQ ID NO: 343, CDR-L1 as depicted in SEQ ID NO: 344, CDR L2 as depicted in SEQ ID NO: 345 and CDR-L3 as depicted in SEQ ID NO: 346; 10 (20) CDR-H1 as depicted in SEQ ID NO: 351, CDR-H2 as depicted in SEQ ID NO: 352, CDR-H3 as depicted in SEQ ID NO: 353, CDR-L1 as depicted in SEQ ID NO: 354, CDR L2 as depicted in SEQ ID NO: 355 and CDR-L3 as depicted in SEQ ID NO: 356; (21) CDR-H1 as depicted in SEQ ID NO: 361, CDR-H2 as depicted in SEQ ID NO: 362, CDR-H3 as depicted in SEQ ID NO: 363, CDR-L1 as depicted in SEQ ID NO: 364, CDR 15 L2 as depicted in SEQ ID NO: 365 and CDR-L3 as depicted in SEQ ID NO: 366; (22) CDR-H1 as depicted in SEQ ID NO: 371, CDR-H2 as depicted in SEQ ID NO: 372, CDR-H3 as depicted in SEQ ID NO: 373, CDR-L1 as depicted in SEQ ID NO: 374, CDR L2 as depicted in SEQ ID NO: 375 and CDR-L3 as depicted in SEQ ID NO: 376; (23) CDR-H1 as depicted in SEQ ID NO: 381, CDR-H2 as depicted in SEQ ID NO: 382, 20 CDR-H3 as depicted in SEQ ID NO: 383, CDR-L1 as depicted in SEQ ID NO: 384, CDR L2 as depicted in SEQ ID NO: 385 and CDR-L3 as depicted in SEQ ID NO: 386; (24) CDR-H1 as depicted in SEQ ID NO: 581, CDR-H2 as depicted in SEQ ID NO: 582, CDR-H3 as depicted in SEQ ID NO: 583, CDR-L1 as depicted in SEQ ID NO: 584, CDR L2 as depicted in SEQ ID NO: 585 and CDR-L3 as depicted in SEQ ID NO: 586; 25 (25) CDR-H1 as depicted in SEQ ID NO: 591, CDR-H2 as depicted in SEQ ID NO: 592, CDR-H3 as depicted in SEQ ID NO: 593, CDR-L1 as depicted in SEQ ID NO: 594, CDR L2 as depicted in SEQ ID NO: 595 and CDR-L3 as depicted in SEQ ID NO: 596; (26) CDR-H1 as depicted in SEQ ID NO: 601, CDR-H2 as depicted in SEQ ID NO: 602, CDR-H3 as depicted in SEQ ID NO: 603, CDR-L1 as depicted in SEQ ID NO: 604, CDR 30 L2 as depicted in SEQ ID NO: 605 and CDR-L3 as depicted in SEQ ID NO: 606; (27) CDR-H1 as depicted in SEQ ID NO: 611, CDR-H2 as depicted in SEQ ID NO: 612, CDR-H3 as depicted in SEQ ID NO: 613, CDR-L1 as depicted in SEQ ID NO: 614, CDR L2 as depicted in SEQ ID NO: 615 and CDR-L3 as depicted in SEQ ID NO: 616; 31 (28) CDR-H1 as depicted in SEQ ID NO: 621, CDR-H2 as depicted in SEQ ID NO: 622, CDR-H3 as depicted in SEQ ID NO: 623, CDR-L1 as depicted in SEQ ID NO: 624, CDR L2 as depicted in SEQ ID NO: 625 and CDR-L3 as depicted in SEQ ID NO: 626; (29) CDR-H1 as depicted in SEQ ID NO: 631, CDR-H2 as depicted in SEQ ID NO: 632, 5 CDR-H3 as depicted in SEQ ID NO: 633, CDR-L1 as depicted in SEQ ID NO: 634, CDR L2 as depicted in SEQ ID NO: 635 and CDR-L3 as depicted in SEQ ID NO: 636; (30) CDR-H1 as depicted in SEQ ID NO: 641, CDR-H2 as depicted in SEQ ID NO: 642, CDR-H3 as depicted in SEQ ID NO: 643, CDR-L1 as depicted in SEQ ID NO: 644, CDR L2 as depicted in SEQ ID NO: 645 and CDR-L3 as depicted in SEQ ID NO: 646; 10 (31) CDR-H1 as depicted in SEQ ID NO: 651, CDR-H2 as depicted in SEQ ID NO: 652, CDR-H3 as depicted in SEQ ID NO: 653, CDR-L1 as depicted in SEQ ID NO: 654, CDR L2 as depicted in SEQ ID NO: 655 and CDR-L3 as depicted in SEQ ID NO: 656; (32) CDR-H1 as depicted in SEQ ID NO: 661, CDR-H2 as depicted in SEQ ID NO: 662, CDR-H3 as depicted in SEQ ID NO: 663, CDR-L1 as depicted in SEQ ID NO: 664, CDR 15 L2 as depicted in SEQ ID NO: 665 and CDR-L3 as depicted in SEQ ID NO: 666; (33) CDR-H1 as depicted in SEQ ID NO: 671, CDR-H2 as depicted in SEQ ID NO: 672, CDR-H3 as depicted in SEQ ID NO: 673, CDR-L1 as depicted in SEQ ID NO: 674, CDR L2 as depicted in SEQ ID NO: 675 and CDR-L3 as depicted in SEQ ID NO: 676; (34) CDR-H1 as depicted in SEQ ID NO: 681, CDR-H2 as depicted in SEQ ID NO: 682, 20 CDR-H3 as depicted in SEQ ID NO: 683, CDR-L1 as depicted in SEQ ID NO: 684, CDR L2 as depicted in SEQ ID NO: 685 and CDR-L3 as depicted in SEQ ID NO: 686; (35) CDR-H1 as depicted in SEQ ID NO: 691, CDR-H2 as depicted in SEQ ID NO: 692, CDR-H3 as depicted in SEQ ID NO: 693, CDR-L1 as depicted in SEQ ID NO: 694, CDR L2 as depicted in SEQ ID NO: 695 and CDR-L3 as depicted in SEQ ID NO: 696; 25 (36) CDR-H1 as depicted in SEQ ID NO: 701, CDR-H2 as depicted in SEQ ID NO: 702, CDR-H3 as depicted in SEQ ID NO: 703, CDR-L1 as depicted in SEQ ID NO: 704, CDR L2 as depicted in SEQ ID NO: 705 and CDR-L3 as depicted in SEQ ID NO: 706; (37) CDR-H1 as depicted in SEQ ID NO: 711, CDR-H2 as depicted in SEQ ID NO: 712, CDR-H3 as depicted in SEQ ID NO: 713, CDR-L1 as depicted in SEQ ID NO: 714, 30 CDR-L2 as depicted in SEQ ID NO: 715 and CDR-L3 as depicted in SEQ ID NO: 716; (38) CDR-H1 as depicted in SEQ ID NO: 721, CDR-H2 as depicted in SEQ ID NO: 722, CDR-H3 as depicted in SEQ ID NO: 723, CDR-L1 as depicted in SEQ ID NO: 724, CDR L2 as depicted in SEQ ID NO: 725 and CDR-L3 as depicted in SEQ ID NO: 726; 32 (39) CDR-H1 as depicted in SEQ ID NO: 731, CDR-H2 as depicted in SEQ ID NO: 732, CDR-H3 as depicted in SEQ ID NO: 733, CDR-L1 as depicted in SEQ ID NO: 734, CDR L2 as depicted in SEQ ID NO: 735 and CDR-L3 as depicted in SEQ ID NO: 736; (40) CDR-H1 as depicted in SEQ ID NO: 741, CDR-H2 as depicted in SEQ ID NO: 742, 5 CDR-H3 as depicted in SEQ ID NO: 743, CDR-L1 as depicted in SEQ ID NO: 744, CDR L2 as depicted in SEQ ID NO: 745 and CDR-L3 as depicted in SEQ ID NO: 746; (41) CDR-H1 as depicted in SEQ ID NO: 751, CDR-H2 as depicted in SEQ ID NO: 752, CDR-H3 as depicted in SEQ ID NO: 753, CDR-L1 as depicted in SEQ ID NO: 754, CDR L2 as depicted in SEQ ID NO: 755 and CDR-L3 as depicted in SEQ ID NO: 756; 10 (42) CDR-H1 as depicted in SEQ ID NO: 761, CDR-H2 as depicted in SEQ ID NO: 762, CDR-H3 as depicted in SEQ ID NO: 763, CDR-L1 as depicted in SEQ ID NO: 764, CDR L2 as depicted in SEQ ID NO: 765 and CDR-L3 as depicted in SEQ ID NO: 766; (43) CDR-H1 as depicted in SEQ ID NO: 771, CDR-H2 as depicted in SEQ ID NO: 772, CDR-H3 as depicted in SEQ ID NO: 773, CDR-L1 as depicted in SEQ ID NO: 774, CDR 15 L2 as depicted in SEQ ID NO: 775 and CDR-L3 as depicted in SEQ ID NO: 776; (44) CDR-H1 as depicted in SEQ ID NO: 781, CDR-H2 as depicted in SEQ ID NO: 782, CDR-H3 as depicted in SEQ ID NO: 783, CDR-L1 as depicted in SEQ ID NO: 784, CDR L2 as depicted in SEQ ID NO: 785 and CDR-L3 as depicted in SEQ ID NO: 786; (45) CDR-H1 as depicted in SEQ ID NO: 791, CDR-H2 as depicted in SEQ ID NO: 792, 20 CDR-H3 as depicted in SEQ ID NO: 793, CDR-L1 as depicted in SEQ ID NO: 794, CDR L2 as depicted in SEQ ID NO: 795 and CDR-L3 as depicted in SEQ ID NO: 796; (46) CDR-H1 as depicted in SEQ ID NO: 801, CDR-H2 as depicted in SEQ ID NO: 802, CDR-H3 as depicted in SEQ ID NO: 803, CDR-L1 as depicted in SEQ ID NO: 804, CDR L2 as depicted in SEQ ID NO: 805 and CDR-L3 as depicted in SEQ ID NO: 806; 25 (47) CDR-H1 as depicted in SEQ ID NO: 811, CDR-H2 as depicted in SEQ ID NO: 812, CDR-H3 as depicted in SEQ ID NO: 813, CDR-L1 as depicted in SEQ ID NO: 814, CDR L2 as depicted in SEQ ID NO: 815 and CDR-L3 as depicted in SEQ ID NO: 816; (48) CDR-H1 as depicted in SEQ ID NO: 821, CDR-H2 as depicted in SEQ ID NO: 822, CDR-H3 as depicted in SEQ ID NO: 823, CDR-L1 as depicted in SEQ ID NO: 824, CDR 30 L2 as depicted in SEQ ID NO: 825 and CDR-L3 as depicted in SEQ ID NO: 826; (49) CDR-H1 as depicted in SEQ ID NO: 831, CDR-H2 as depicted in SEQ ID NO: 832, CDR-H3 as depicted in SEQ ID NO: 833, CDR-L1 as depicted in SEQ ID NO: 834, CDR L2 as depicted in SEQ ID NO: 835 and CDR-L3 as depicted in SEQ ID NO: 836; 33 (50) CDR-H1 as depicted in SEQ ID NO: 961, CDR-H2 as depicted in SEQ ID NO: 962, CDR-H3 as depicted in SEQ ID NO: 963, CDR-L1 as depicted in SEQ ID NO: 964, CDR L2 as depicted in SEQ ID NO: 965 and CDR-L3 as depicted in SEQ ID NO: 966; (51) CDR-H1 as depicted in SEQ ID NO: 971, CDR-H2 as depicted in SEQ ID NO: 972, 5 CDR-H3 as depicted in SEQ ID NO: 973, CDR-L1 as depicted in SEQ ID NO: 974, CDR L2 as depicted in SEQ ID NO: 975 and CDR-L3 as depicted in SEQ ID NO: 976; (52) CDR-H1 as depicted in SEQ ID NO: 981, CDR-H2 as depicted in SEQ ID NO: 982, CDR-H3 as depicted in SEQ ID NO: 983, CDR-L1 as depicted in SEQ ID NO: 984, CDR L2 as depicted in SEQ ID NO: 985 and CDR-L3 as depicted in SEQ ID NO: 986; and 10 (53) CDR-H1 as depicted in SEQ ID NO: 991, CDR-H2 as depicted in SEQ ID NO: 992, CDR-H3 as depicted in SEQ ID NO: 993, CDR-L1 as depicted in SEQ ID NO: 994, CDR L2 as depicted in SEQ ID NO: 995 and CDR-L3 as depicted in SEQ ID NO: 996. In yet another embodiment, the first binding domain of the binding molecule comprises a 15 VH region selected from the group consisting of a VH region as depicted in SEQ ID NO: 7, SEQ ID NO: 17, SEQ ID NO: 27, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 67, SEQ ID NO: 77, SEQ ID NO: 167, SEQ ID NO: 177, SEQ ID NO: 187, SEQ ID NO: 197, SEQ ID NO: 207, SEQ ID NO: 217, SEQ ID NO: 227, SEQ ID NO: 317, SEQ ID NO: 327, SEQ ID NO: 337, SEQ ID NO: 347, SEQ ID NO: 357, SEQ ID NO: 367, SEQ ID 20 NO: 377, SEQ ID NO: 387, SEQ ID NO: 587, SEQ ID NO: 597, SEQ ID NO: 607, SEQ ID NO: 617, SEQ ID NO: 627, SEQ ID NO: 637, SEQ ID NO: 647, SEQ ID NO: 657, SEQ ID NO: 667, SEQ ID NO: 677, SEQ ID NO: 687, SEQ ID NO: 697, SEQ ID NO: 707, SEQ ID NO: 717, SEQ ID NO: 727, SEQ ID NO: 737, SEQ ID NO: 747, SEQ ID NO: 757, SEQ ID NO: 767, SEQ ID NO: 777, SEQ ID NO: 787, SEQ ID NO: 797, SEQ ID NO: 807, SEQ ID 25 NO: 817, SEQ ID NO: 827, SEQ ID NO: 837, SEQ ID NO: 967, SEQ ID NO: 977, SEQ ID NO: 987, and SEQ ID NO: 997. In another embodiment, the first binding domain of the binding molecule comprises a VL region selected from the group consisting of a VL region as depicted in SEQ ID in SEQ ID NO: 8, 30 SEQ ID NO: 18, SEQ ID NO: 28, SEQ ID NO: 38, SEQ ID NO: 48, SEQ ID NO: 58, SEQ ID NO: 68, SEQ ID NO: 78, SEQ ID NO: 168, SEQ ID NO: 178, SEQ ID NO: 188, SEQ ID NO: 198, SEQ ID NO: 208, SEQ ID NO: 218, SEQ ID NO: 228, SEQ ID NO: 318, SEQ ID NO: 328, SEQ ID NO: 338, SEQ ID NO: 348, SEQ ID NO: 358, SEQ ID NO: 368, SEQ ID NO: 378, SEQ ID NO: 388, SEQ ID NO: 588, SEQ ID NO: 598, SEQ ID NO: 608, SEQ ID 35 NO: 618, SEQ ID NO: 628, SEQ ID NO: 638, SEQ ID NO: 648, SEQ ID NO: 658, SEQ ID 34 NO: 668, SEQ ID NO: 678, SEQ ID NO: 688, SEQ ID NO: 698, SEQ ID NO: 708, SEQ ID NO: 718, SEQ ID NO: 728, SEQ ID NO: 738, SEQ ID NO: 748, SEQ ID NO: 758, SEQ ID NO: 768, SEQ ID NO: 778, SEQ ID NO: 788, SEQ ID NO: 798, SEQ ID NO: 808, SEQ ID NO: 818, SEQ ID NO: 828, SEQ ID NO: 838, SEQ ID NO: 968, SEQ ID NO: 978, SEQ ID 5 NO: 988, and SEQ ID NO: 998. In one embodiment, the first binding domain of the binding molecule comprises a VH region and a VL region selected from the group consisting of: (1) a VH region as depicted in SEQ ID NO: 7, and a VL region as depicted in SEQ ID 10 NO: 8; (2) a VH region as depicted in SEQ ID NO: 17, and a VL region as depicted in SEQ ID NO: 18; (3) a VH region as depicted in SEQ ID NO: 27, and a VL region as depicted in SEQ ID NO: 28; 15 (4) a VH region as depicted in SEQ ID NO: 37, and a VL region as depicted in SEQ ID NO: 38; (5) a VH region as depicted in SEQ ID NO: 47, and a VL region as depicted in SEQ ID NO: 48; (6) a VH region as depicted in SEQ ID NO: 57, and a VL region as depicted in SEQ ID 20 NO: 58; (7) a VH region as depicted in SEQ ID NO: 67, and a VL region as depicted in SEQ ID NO: 68; (8) a VH region as depicted in SEQ ID NO: 77, and a VL region as depicted in SEQ ID NO: 78; 25 (9) a VH region as depicted in SEQ ID NO: 167, and a VL region as depicted in SEQ ID NO: 168; (10) a VH region as depicted in SEQ ID NO: 177, and a VL region as depicted in SEQ ID NO: 178; (11) a VH region as depicted in SEQ ID NO: 187, and a VL region as depicted in 30 SEQ ID NO: 188; (12) a VH region as depicted in SEQ ID NO: 197, and a VL region as depicted in SEQ ID NO: 198; (13) a VH region as depicted in SEQ ID NO: 207, and a VL region as depicted in SEQ ID NO: 208; 35 (14) a VH region as depicted in SEQ ID NO: 217, and a VL region as depicted in SEQ ID NO: 218; (15) a VH region as depicted in SEQ ID NO: 227, and a VL region as depicted in SEQ ID NO: 228; 5 (16) a VH region as depicted in SEQ ID NO: 317, and a VL region as depicted in SEQ ID NO: 318; (17) a VH region as depicted in SEQ ID NO: 327, and a VL region as depicted in SEQ ID NO: 328; (18) a VH region as depicted in SEQ ID NO: 337, and a VL region as depicted in 10 SEQ ID NO: 338; (19) a VH region as depicted in SEQ ID NO: 347, and a VL region as depicted in SEQ ID NO: 348; (20) a VH region as depicted in SEQ ID NO: 357, and a VL region as depicted in SEQ ID NO: 358; 15 (21) a VH region as depicted in SEQ ID NO: 367, and a VL region as depicted in SEQ ID NO: 368; (22) a VH region as depicted in SEQ ID NO: 377, and a VL region as depicted in SEQ ID NO: 378; (23) a VH region as depicted in SEQ ID NO: 387, and a VL region as depicted in 20 SEQ ID NO: 388; (24) a VH region as depicted in SEQ ID NO: 587, and a VL region as depicted in SEQ ID NO: 588; (25) a VH region as depicted in SEQ ID NO: 597, and a VL region as depicted in SEQ ID NO: 598; 25 (26) a VH region as depicted in SEQ ID NO: 607, and a VL region as depicted in SEQ ID NO: 608; (27) a VH region as depicted in SEQ ID NO: 617, and a VL region as depicted in SEQ ID NO: 618; (28) a VH region as depicted in SEQ ID NO: 627, and a VL region as depicted in 30 SEQ ID NO: 628; (29) a VH region as depicted in SEQ ID NO: 637, and a VL region as depicted in SEQ ID NO: 638; (30) a VH region as depicted in SEQ ID NO: 647, and a VL region as depicted in SEQ ID NO: 648; 36 (31) a VH region as depicted in SEQ ID NO: 657, and a VL region as depicted in SEQ ID NO: 658; (32) a VH region as depicted in SEQ ID NO: 667, and a VL region as depicted in SEQ ID NO: 668; 5 (33) a VH region as depicted in SEQ ID NO: 677, and a VL region as depicted in SEQ ID NO: 678; (34) a VH region as depicted in SEQ ID NO: 687, and a VL region as depicted in SEQ ID NO: 688; (35) a VH region as depicted in SEQ ID NO: 697, and a VL region as depicted in 10 SEQ ID NO: 698; (36) a VH region as depicted in SEQ ID NO: 707, and a VL region as depicted in SEQ ID NO: 708; (37) a VH region as depicted in SEQ ID NO: 717, and a VL region as depicted in SEQ ID NO: 718; 15 (38) a VH region as depicted in SEQ ID NO: 727, and a VL region as depicted in SEQ ID NO: 728; (39) a VH region as depicted in SEQ ID NO: 737, and a VL region as depicted in SEQ ID NO: 738; (40) a VH region as depicted in SEQ ID NO: 747, and a VL region as depicted in 20 SEQ ID NO: 748; (41) a VH region as depicted in SEQ ID NO: 757, and a VL region as depicted in SEQ ID NO: 758; (42) a VH region as depicted in SEQ ID NO: 767, and a VL region as depicted in SEQ ID NO: 768; 25 (43) a VH region as depicted in SEQ ID NO: 777, and a VL region as depicted in SEQ ID NO: 778; (44) a VH region as depicted in SEQ ID NO: 787, and a VL region as depicted in SEQ ID NO: 788; (45) a VH region as depicted in SEQ ID NO: 797, and a VL region as depicted in 30 SEQ ID NO: 798; (46) a VH region as depicted in SEQ ID NO: 807, and a VL region as depicted in SEQ ID NO: 808; (47) a VH region as depicted in SEQ ID NO: 817, and a VL region as depicted in SEQ ID NO: 818; 37 (48) a VH region as depicted in SEQ ID NO: 827, and a VL region as depicted in SEQ ID NO: 828; (49) a VH region as depicted in SEQ ID NO: 837, and a VL region as depicted in SEQ ID NO: 838; 5 (50) a VH region as depicted in SEQ ID NO: 967, and a VL region as depicted in SEQ ID NO: 968; (51) a VH region as depicted in SEQ ID NO: 977, and a VL region as depicted in SEQ ID NO: 978; (52) a VH region as depicted in SEQ ID NO: 987, and a VL region as depicted in 10 SEQ ID NO: 988; and (53) a VH region as depicted in SEQ ID NO: 997, and a VL region as depicted in SEQ ID NO: 998. In one example, the first binding domain comprises an amino acid sequence selected from the 15 group consisting of SEQ ID NO: 9, SEQ ID NO: 19, SEQ ID NO: 29, SEQ ID NO: 39, SEQ ID NO: 49, SEQ ID NO: 59, SEQ ID NO: 69, SEQ ID NO: 79, SEQ ID NO: 169, SEQ ID NO: 179, SEQ ID NO: 189, SEQ ID NO: 199, SEQ ID NO: 209, SEQ ID NO: 219, SEQ ID NO: 229, SEQ ID NO: 319, SEQ ID NO: 329, SEQ ID NO: 339, SEQ ID NO: 349, SEQ ID NO: 359, SEQ ID NO: 369, SEQ ID NO: 379, SEQ ID NO: 389, SEQ ID NO: 589, SEQ ID NO: 599, 20 SEQ ID NO: 609, SEQ ID NO: 619, SEQ ID NO: 629, SEQ ID NO: 639, SEQ ID NO: 649, SEQ ID NO: 659, SEQ ID NO: 669, SEQ ID NO: 679, SEQ ID NO: 689, SEQ ID NO: 699, SEQ ID NO: 709, SEQ ID NO: 719, SEQ ID NO: 729, SEQ ID NO: 739, SEQ ID NO: 749, SEQ ID NO: 759, SEQ ID NO: 769, SEQ ID NO: 779, SEQ ID NO: 789, SEQ ID NO: 799, SEQ ID NO: 809, SEQ ID NO: 819, SEQ ID NO: 829, SEQ ID NO: 839, SEQ ID NO: 969, 25 SEQ ID NO: 979, SEQ ID NO: 989, and SEQ ID NO: 999. It is preferred that a binding molecule of the present invention has a CDR-H3 region of 12 amino acids in length, wherein a tyrosine (Y) residue is present at position 3, 4 and 12. A preferred CDR-H3 is shown in SEQ ID NOs: 43, 193, 333, 613, 703, 733, 823, or 973. Accordingly, a 30 binding molecule of the present invention has in a preferred embodiment a CDR-H3 shown in of SEQ ID NOs: 43, 193, 333, 613, 703, 733, 823, or 973. Preferred is a binding molecule having the amino acid sequence shown in SEQ ID NO: 340. Also preferred is a binding molecule having the amino acid sequence shown in or SEQ ID NO: 35 980. 38 The binding molecule of the present invention is preferably an "isolated" binding molecule. "Isolated" when used to describe the binding molecule disclosed herein, means a binding molecule that has been identified, separated and/or recovered from a component of its production environment. Preferably, the isolated binding molecule is free of association with all 5 other components from its production environment. Contaminant components of its production environment, such as that resulting from recombinant transfected cells, are materials that would typically interfere with diagnostic or therapeutic uses for the polypeptide, and may include enzymes, hormones, and other proteinaceous or non-proteinaceous solutes. In preferred embodiments, the binding molecule will be purified (1) to a degree sufficient to obtain at least 15 10 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (2) to homogeneity by SDS-PAGE under non-reducing or reducing conditions using Coomassie blue or, preferably, silver stain. Ordinarily, however, an isolated antibody will be prepared by at least one purification step. 15 Amino acid sequence modifications of the binding molecules described herein are contemplated. For example, it may be desirable to improve the binding affinity and/or other biological properties of the antibody. Amino acid sequence variants of the binding molecules are prepared by introducing appropriate nucleotide changes into the binding molecules nucleic acid, or by peptide synthesis. 20 Such modifications include, for example, deletions from, and/or insertions into, and/or substitutions of, residues within the amino acid sequences of the binding molecules. Any combination of deletion, insertion, and substitution is made to arrive at the final construct, provided that the final construct possesses the desired characteristics. The amino acid changes 25 also may alter post-translational processes of the binding molecules, such as changing the number or position of glycosylation sites. Preferably, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 amino acids may be substituted in a CDR, while 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 25 amino acids may be substituted in the framework regions (FRs). The substitutions are preferably conservative substitutions as described herein. Additionally or alternatively, 1, 2, 3, 4, 30 5, or 6 amino acids may be inserted or deleted in each of the CDRs (of course, dependent on their length), while 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, or 25 amino acids may be inserted or deleted in each of the FRs. A useful method for identification of certain residues or regions of the binding molecules that are 35 preferred locations for mutagenesis is called "alanine scanning mutagenesis" as described by 39 Cunningham and Wells in Science, 244: 1081-1085 (1989). Here, a residue or group of target residues within the binding molecule is/are identified (e.g. charged residues such as arg, asp, his, lys, and glu) and replaced by a neutral or negatively charged amino acid (most preferably alanine or polyalanine) to affect the interaction of the amino acids with the epitope. 5 Those amino acid locations demonstrating functional sensitivity to the substitutions then are refined by introducing further or other variants at, or for, the sites of substitution. Thus, while the site for introducing an amino acid sequence variation is predetermined, the nature of the mutation per se needs not to be predetermined. For example, to analyze the performance of a 10 mutation at a given site, ala scanning or random mutagenesis is conducted at a target codon or region and the expressed binding molecule variants are screened for the desired activity. Preferably, amino acid sequence insertions include amino- and/or carboxyl-terminal fusions ranging in length from 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 residues to polypeptides containing a 15 hundred or more residues, as well as intrasequence insertions of single or multiple amino acid residues. An insertional variant of the binding molecule includes the fusion to the N-or C terminus of the antibody to an enzyme or a fusion to a polypeptide which increases the serum half-life of the antibody. 20 Another type of variant is an amino acid substitution variant. These variants have preferably at least 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 amino acid residues in the binding molecule replaced by a different residue. The sites of greatest interest for substitutional mutagenesis include the CDRs of the heavy and/or light chain, in particular the hypervariable regions, but FR alterations in the heavy and/or light chain are also contemplated. 25 For example, if a CDR sequence encompasses 6 amino acids, it is envisaged that one, two or three of these amino acids are substituted. Similarly, if a CDR sequence encompasses 15 amino acids it is envisaged that one, two, three, four, five or six of these amino acids are substituted. 30 Generally, if amino acids are substituted in one or more or all of the CDRs of the heavy and/or light chain, it is preferred that the then-obtained "substituted" sequence is at least 60%, more preferably 65%, even more preferably 70%, particularly preferably 75%, more particularly preferably 80% identical to the "original" CDR sequence. This means that it is dependent of the 35 length of the CDR to which degree it is identical to the "substituted" sequence. For example, a 40 CDR having 5 amino acids is preferably 80% identical to its substituted sequence in order to have at least one amino acid substituted. Accordingly, the CDRs of the binding molecule may have different degrees of identity to their substituted sequences, e.g., CDRL1 may have 80%, while CDRL3 may have 90%. 5 Preferred substitutions (or replacements) are conservative substitutions. However, any substitution (including non-conservative substitution or one or more from the "exemplary substitutions" listed in Table 1, below) is envisaged as long as the binding molecule retains its capability to bind to BCMA via the first binding domain and to CD3 epsilon via the second 10 binding domain and/or its CDRs have an identity to the then substituted sequence (at least 60%, more preferably 65%, even more preferably 70%, particularly preferably 75%, more particularly preferably 80% identical to the "original" CDR sequence). Conservative substitutions are shown in Table 1 under the heading of "preferred substitutions". If 15 such substitutions result in a change in biological activity, then more substantial changes, denominated "exemplary substitutions" in Table 1, or as further described below in reference to amino acid classes, may be introduced and the products screened for a desired characteristic. Table 1: Amino Acid Substitutions Original Exemplary Substitutions Preferred Substitutions Ala (A) val, leu, ile val Arg (R) lys, gin, asn lys Asn (N) gin, his, asp, lys, arg gIn Asp (D) glu, asn glu Cys (C) ser, ala ser GIn (Q) asn, glu asn Glu (E) asp, gIn asp Gly (G) ala ala His (H) asn, gin, lys, arg arg Ile (1) leu, val, met, ala, phe leu Leu (L) norleucine, ile, val, met, ala ile Lys (K) arg, gln, asn arg Met (M) leu, phe, ile leu Phe (F) leu, val, ile, ala, tyr tyr 41 Pro (P) ala ala Ser (S) thr thr Thr (T) ser ser Trp (W) tyr, phe tyr Tyr (Y) trp, phe, thr, ser phe Val (V) ile, leu, met, phe, ala leu Substantial modifications in the biological properties of the binding molecule of the present invention are accomplished by selecting substitutions that differ significantly in their effect on 5 maintaining (a) the structure of the polypeptide backbone in the area of the substitution, for example, as a sheet or helical conformation, (b) the charge or hydrophobicity of the molecule at the target site, or (c) the bulk of the side chain. Naturally occurring residues are divided into groups based on common side-chain properties: (1) hydrophobic: norleucine, met, ala, val, leu, ile; (2) neutral hydrophilic: cys, ser, thr; (3) acidic: asp, glu; (4) basic: asn, gin, his, lys, arg; (5) 10 residues that influence chain orientation: gly, pro; and (6) aromatic : trp, tyr, phe. Non-conservative substitutions will entail exchanging a member of one of these classes for another class. Any cysteine residue not involved in maintaining the proper conformation of the binding molecule may be substituted, generally with serine, to improve the oxidative stability of 15 the molecule and prevent aberrant crosslinking. Conversely, cysteine bond(s) may be added to the antibody to improve its stability (particularly where the antibody is an antibody fragment such as an Fv fragment). A particularly preferred type of substitutional variant involves substituting one or more 20 hypervariable region residues of a parent antibody (e. g. a humanized or human antibody). Generally, the resulting variant(s) selected for further development will have improved biological properties relative to the parent antibody from which they are generated. A convenient way for generating such substitutional variants involves affinity maturation using phage display. Briefly, several hypervariable region sites (e. g. 6-7 sites) are mutated to generate all possible amino 25 acid substitutions at each site. The antibody variants thus generated are displayed in a monovalent fashion from filamentous phage particles as fusions to the gene 11 product of M13 packaged within each particle. The phage-displayed variants are then screened for their biological activity (e. g. binding affinity) as herein disclosed. In order to identify candidate hypervariable region sites for modification, alanine scanning mutagenesis can be performed to 42 identify hypervariable region residues contributing significantly to antigen binding. Alternatively, or additionally, it may be beneficial to analyze a crystal structure of the antigen-antibody complex to identify contact points between the binding domain and, e.g., human BCMA. Such contact residues and neighbouring residues are candidates for substitution according to the 5 techniques elaborated herein. Once such variants are generated, the panel of variants is subjected to screening as described herein and antibodies with superior properties in one or more relevant assays may be selected for further development. Other modifications of the binding molecule are contemplated herein. For example, the binding 10 molecule may be linked to one of a variety of non-proteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, polyoxyalkylenes, or copolymers of polyethylene glycol and polypropylene glycol. The binding molecule may also be entrapped in microcapsules prepared, for example, by coacervation techniques or by interfacial polymerization (for example, hydroxymethylcellulose or gelatine-microcapsules and poly (methylmethacylate) microcapsules, 15 respectively), in colloidal drug delivery systems (for example, liposomes, albumin microspheres, microemulsions, nanoparticles and nanocapsules), or in macroemulsions. Such techniques are disclosed in Remington's Pharmaceutical Sciences, 16th edition, Oslo, A., Ed., (1980). The binding molecules disclosed herein may also be formulated as immuno-liposomes. A 20 "liposome" is a small vesicle composed of various types of lipids, phospholipids and/or surfactant which is useful for delivery of a drug to a mammal. The components of the liposome are commonly arranged in a bilayer formation, similar to the lipid arrangement of biological membranes. Liposomes containing the antibody are prepared by methods known in the art, such as described in Epstein et al., Proc. Natl. Acad. Sci. USA, 82: 3688 (1985); Hwang et al. , 25 Proc. Natl Acad. Sci. USA, 77: 4030 (1980); US Pat. Nos. 4,485,045 and 4,544,545; and WO 97/38731 published October 23, 1997. Liposomes with enhanced circulation time are disclosed in US Patent No. 5,013, 556. Particularly useful liposomes can be generated by the reverse phase evaporation method with a lipid composition comprising phosphatidylcholine, cholesterol and PEG-derivatized phosphatidylethanolamine (PEG-PE). Liposomes are extruded 30 through filters of defined pore size to yield liposomes with the desired diameter. Fab' fragments of the antibody of the present invention can be conjugated to the liposomes as described in Martin et al. J. Biol. Chem. 257: 286-288 (1982) via a disulfide interchange reaction. A chemotherapeutic agent is optionally contained within the liposome. See Gabizon et al. J. National Cancer Inst. 81 (19) 1484 (1989). 35 43 When using recombinant techniques, the binding molecule can be produced intracellularly, in the periplasmic space, or directly secreted into the medium. If the binding molecule is produced intracellularly, as a first step, the particulate debris, either host cells or lysed fragments, are removed, for example, by centrifugation or ultrafiltration. Carter et al., Bio/Technology 10: 163 5 167 (1992) describe a procedure for isolating antibodies which are secreted to the periplasmic space of E. coli. The binding molecule composition prepared from the cells can be purified using, for example, hydroxylapatite chromatography, gel electrophoresis, dialysis, and affinity chromatography, with 10 affinity chromatography being the preferred purification technique. In a further aspect, the present invention relates to a nucleic acid sequence encoding a binding molecule of the invention. The term "nucleic acid" is well known to the skilled person and encompasses DNA (such as cDNA) and RNA (such as mRNA). The nucleic acid can be double 15 stranded and single stranded, linear and circular. Said nucleic acid molecule is preferably comprised in a vector which is preferably comprised in a host cell. Said host cell is, e.g. after transformation or transfection with the nucleic acid sequence of the invention, capable of expressing the binding molecule. For that purpose the nucleic acid molecule is operatively linked with control sequences. 20 A vector is a nucleic acid molecule used as a vehicle to transfer (foreign) genetic material into a cell. The term "vector" encompasses - but is not restricted to - plasmids, viruses, cosmids and artificial chromosomes. In general, engineered vectors comprise an origin of replication, a multicloning site and a selectable marker. The vector itself is generally a nucleotide sequence, 25 commonly a DNA sequence, that comprises an insert (transgene) and a larger sequence that serves as the "backbone" of the vector. Modern vectors may encompass additional features besides the transgene insert and a backbone: promoter, genetic marker, antibiotic resistance, reporter gene, targeting sequence, protein purification tag. Vectors called expression vectors (expression constructs) specifically are for the expression of the transgene in the target cell, and 30 generally have control sequences such as a promoter sequence that drives expression of the transgene. Insertion of a vector into the target cell is usually called "transformation" for bacterial cells, "transfection" for eukaryotic cells, although insertion of a viral vector is also called "transduction". 44 As used herein, the term "host cell" is intended to refer to a cell into which a nucleic acid encoding the binding molecule of the invention is introduced by way of transformation, transfection and the like. It should be understood that such terms refer not only to the particular subject cell but to the progeny or potential progeny of such a cell. Because certain modifications 5 may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein. As used herein, the term "expression" includes any step involved in the production of a binding 10 molecule of the invention including, but not limited to, transcription, post-transcriptional modification, translation, post-translational modification, and secretion. The term "control sequences" refers to DNA sequences necessary for the expression of an operably linked coding sequence in a particular host organism. The control sequences that are 15 suitable for prokaryotes, for example, include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers. A nucleic acid is "operably linked" when it is placed into a functional relationship with another 20 nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, "operably linked" 25 means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is accomplished by ligation at convenient restriction sites. If such sites do not exist, the synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. 30 The terms "host cell," "target cell" or "recipient cell" are intended to include any individual cell or cell culture that can be or has/have been recipients for vectors or the incorporation of exogenous nucleic acid molecules, polynucleotides and/or proteins. It also is intended to include progeny of a single cell, and the progeny may not necessarily be completely identical (in morphology or in genomic or total DNA complement) to the original parent cell due to natural, 35 accidental, or deliberate mutation. The cells may be prokaryotic or eukaryotic, and include but 45 are not limited to bacterial cells, yeast cells, animal cells, and mammalian cells, e.g., murine, rat, macaque or human. Suitable host cells include prokaryotes and eukaryotic host cells including yeasts, fungi, insect 5 cells and mammalian cells. The binding molecule of the invention can be produced in bacteria. After expression, the binding molecule of the invention, preferably the binding molecule is isolated from the E. coli cell paste in a soluble fraction and can be purified through, e.g., affinity chromatography and/or size 10 exclusion. Final purification can be carried out similar to the process for purifying antibody expressed e. g, in CHO cells. In addition to prokaryotes, eukaryotic microbes such as filamentous fungi or yeast are suitable cloning or expression hosts for the binding molecule of the invention. Saccharomyces 15 cerevisiae, or common baker's yeast, is the most commonly used among lower eukaryotic host microorganisms. However, a number of other genera, species, and strains are commonly available and useful herein, such as Schizosaccharomyces pombe, Kluyveromyces hosts such as, e.g., K. lactis, K. fragilis (ATCC 12424), K. bulgaricus (ATCC 16045), K. wickeramii (ATCC 24178), K. waltii (ATCC 56500), K. drosophilarum (ATCC 36906), K. thermotolerans, and 20 K. marxianus; yarrowia (EP 402 226); Pichia pastors (EP 183 070); Candida; Trichoderma reesia (EP 244 234); Neurospora crassa; Schwanniomyces such as Schwanniomyces occidentalis; and filamentous fungi such as, e.g., Neurospora, Penicillium, Tolypocladium, and Aspergillus hosts such as A. nidulans and A. niger. 25 Suitable host cells for the expression of glycosylated binding molecule of the invention, preferably antibody derived binding molecules are derived from multicellular organisms. Examples of invertebrate cells include plant and insect cells. Numerous baculoviral strains and variants and corresponding permissive insect host cells from hosts such as Spodoptera frugiperda (caterpillar), Aedes aegypti (mosquito), Aedes albopictus (mosquito), Drosophila 30 melanogaster (fruit fly), and Bombyx mori have been identified. A variety of viral strains for transfection are publicly available, e. g. , the L-1 variant of Autographa califomica NPV and the Bm-5 strain of Bombyx mori NPV, and such viruses may be used as the virus herein according to the present invention, particularly for transfection of Spodoptera frugiperda cells. 46 Plant cell cultures of cotton, corn, potato, soybean, petunia, tomato, Arabidopsis and tobacco can also be utilized as hosts. Cloning and expression vectors useful in the production of proteins in plant cell culture are known to those of skill in the art. See e.g. Hiatt et al., Nature (1989) 342: 76-78, Owen et a/. (1992) Bio/Technology 10: 790-794, Artsaenko et al. (1995) The 5 Plant J 8: 745-750, and Fecker et al. (1996) Plant Mol Biol 32: 979-986. However, interest has been greatest in vertebrate cells, and propagation of vertebrate cells in culture (tissue culture) has become a routine procedure. Examples of useful mammalian host cell lines are monkey kidney CV1 line transformed by SV40 (COS-7, ATCC CRL 1651); human 10 embryonic kidney line (293 or 293 cells subcloned for growth in suspension culture, Graham et al. , J. Gen Virol. 36 : 59 (1977)); baby hamster kidney cells (BHK, ATCC CCL 10); Chinese hamster ovary cells/-DHFR (CHO, Urlaub et al. , Proc. NatI. Acad. Sci. USA 77: 4216 (1980)); mouse sertoli cells (TM4, Mather, Biol. Reprod. 23: 243-251 (1980)); monkey kidney cells (CVI ATCC CCL 70); African green monkey kidney cells (VERO-76, ATCC CRL1587) ; human 15 cervical carcinoma cells (HELA, ATCC CCL 2); canine kidney cells (MDCK, ATCC CCL 34); buffalo rat liver cells (BRL 3A, ATCC CRL 1442); human lung cells (W138, ATCC CCL 75); human liver cells (Hep G2,1413 8065); mouse mammary tumor (MMT 060562, ATCC CCL5 1); TRI cells (Mather et al., Annals N. Y Acad. Sci. 383 : 44-68 (1982)) MRC 5 cells; FS4 cells; and a human hepatoma line (Hep G2). 20 When using recombinant techniques, the binding molecule of the invention can be produced intracellularly, in the periplasmic space, or directly secreted into the medium. If the binding molecule is produced intracellularly, as a first step, the particulate debris, either host cells or lysed fragments, are removed, for example, by centrifugation or ultrafiltration. Carter et al., 25 Bio/Technology 10: 163-167 (1992) describe a procedure for isolating antibodies which are secreted to the periplasmic space of E. coli. Briefly, cell paste is thawed in the presence of sodium acetate (pH 3.5), EDTA, and phenylmethylsulfonylfluoride (PMSF) over about 30 min. Cell debris can be removed by centrifugation. Where the antibody is secreted into the medium, supernatants from such expression systems are generally first concentrated using a 30 commercially available protein concentration filter, for example, an Amicon or Millipore Pellicon ultrafiltration unit. A protease inhibitor such as PMSF may be included in any of the foregoing steps to inhibit proteolysis and antibiotics may be included to prevent the growth of adventitious contaminants. 47 The binding molecule of the invention prepared from the host cells can be purified using, for example, hydroxylapatite chromatography, gel electrophoresis, dialysis, and affinity chromatography, with affinity chromatography being the preferred purification technique. 5 The matrix to which the affinity ligand is attached is most often agarose, but other matrices are available. Mechanically stable matrices such as controlled pore glass or poly (styrenedivinyl) benzene allow for faster flow rates and shorter processing times than can be achieved with agarose. Where the binding molecule of the invention comprises a CH3 domain, the Bakerbond ABXMresin (J. T. Baker, Phillipsburg, NJ) is useful for purification. Other techniques for protein 10 purification such as fractionation on an ion-exchange column, ethanol precipitation, Reverse Phase HPLC, chromatography on silica, chromatography on heparin SEPHAROSETM chromatography on an anion or cation exchange resin (such as a polyaspartic acid column), chromato-focusing, SDS-PAGE, and ammonium sulfate precipitation are also available depending on the antibody to be recovered. 15 In another aspect, processes are provided for producing binding molecules of the invention, said processes comprising culturing a host cell defined herein under conditions allowing the expression of the binding molecule and recovering the produced binding molecule from the culture. 20 The term "culturing" refers to the in vitro maintenance, differentiation, growth, proliferation and/or propagation of cells under suitable conditions in a medium. In an alternative embodiment, compositions are provided comprising a binding molecule of the 25 invention, or produced according to the process of the invention. Preferably, said composition is a pharmaceutical composition. As used herein, the term "pharmaceutical composition" relates to a composition for administration to a patient, preferably a human patient. The particular preferred pharmaceutical 30 composition of this invention comprises the binding molecule of the invention. Preferably, the pharmaceutical composition comprises suitable formulations of carriers, stabilizers and/or excipients. In a preferred embodiment, the pharmaceutical composition comprises a composition for parenteral, transdermal, intraluminal, intraarterial, intrathecal and/or intranasal administration or by direct injection into tissue. It is in particular envisaged that said composition 35 is administered to a patient via infusion or injection. Administration of the suitable compositions 48 may be effected by different ways, e.g., by intravenous, intraperitoneal, subcutaneous, intramuscular, topical or intradermal administration. In particular, the present invention provides for an uninterrupted administration of the suitable composition. As a non-limiting example, uninterrupted, i.e. continuous administration may be realized by a small pump system worn by 5 the patient for metering the influx of therapeutic agent into the body of the patient. The pharmaceutical composition comprising the binding molecule of the invention can be administered by using said pump systems. Such pump systems are generally known in the art, and commonly rely on periodic exchange of cartridges containing the therapeutic agent to be infused. When exchanging the cartridge in such a pump system, a temporary interruption of the 10 otherwise uninterrupted flow of therapeutic agent into the body of the patient may ensue. In such a case, the phase of administration prior to cartridge replacement and the phase of administration following cartridge replacement would still be considered within the meaning of the pharmaceutical means and methods of the invention together make up one "uninterrupted administration" of such therapeutic agent. 15 The continuous or uninterrupted administration of these binding molecules of the invention may be intravenous or subcutaneous by way of a fluid delivery device or small pump system including a fluid driving mechanism for driving fluid out of a reservoir and an actuating mechanism for actuating the driving mechanism. Pump systems for subcutaneous 20 administration may include a needle or a cannula for penetrating the skin of a patient and delivering the suitable composition into the patient's body. Said pump systems may be directly fixed or attached to the skin of the patient independently of a vein, artery or blood vessel, thereby allowing a direct contact between the pump system and the skin of the patient. The pump system can be attached to the skin of the patient for 24 hours up to several days. The 25 pump system may be of small size with a reservoir for small volumes. As a non-limiting example, the volume of the reservoir for the suitable pharmaceutical composition to be administered can be between 0.1 and 50 ml. The continuous administration may be transdermal by way of a patch worn on the skin and 30 replaced at intervals. One of skill in the art is aware of patch systems for drug delivery suitable for this purpose. It is of note that transdermal administration is especially amenable to uninterrupted administration, as exchange of a first exhausted patch can advantageously be accomplished simultaneously with the placement of a new, second patch, for example on the surface of the skin immediately adjacent to the first exhausted patch and immediately prior to 35 removal of the first exhausted patch. Issues of flow interruption or power cell failure do not arise. 49 The inventive compositions may further comprise a pharmaceutically acceptable carrier. Examples of suitable pharmaceutical carriers are well known in the art and include solutions, e.g. phosphate buffered saline solutions, water, emulsions, such as oil/water emulsions, various 5 types of wetting agents, sterile solutions, liposomes, etc. Compositions comprising such carriers can be formulated by well known conventional methods. Formulations can comprise carbohydrates, buffer solutions, amino acids and/or surfactants. Carbohydrates may be non reducing sugars, preferably trehalose, sucrose, octasulfate, sorbitol or xylitol. In general, as used herein, "pharmaceutically acceptable carrier" means any and all solvents, dispersion 10 media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, compatible with pharmaceutical administration. The use of such media and agents for pharmaceutically active substances is well known in the art. Acceptable carriers, excipients, or stabilizers are nontoxic to recipients at the dosages and concentrations employed and include: additional buffering agents; preservatives; co-solvents; antioxidants, including ascorbic acid and 15 methionine; chelating agents such as EDTA; metal complexes (e.g., Zn-protein complexes); biodegradable polymers, such as polyesters; salt-forming counter-ions, such as sodium, polyhydric sugar alcohols; amino acids, such as alanine, glycine, asparagine, 2-phenylalanine, and threonine; sugars or sugar alcohols, such as trehalose, sucrose, octasulfate, sorbitol or xylitol stachyose, mannose, sorbose, xylose, ribose, myoinisitose, galactose, lactitol, ribitol, 20 myoinisitol, galactitol, glycerol, cyclitols (e.g., inositol), polyethylene glycol; sulfur containing reducing agents, such as glutathione, thioctic acid, sodium thioglycolate, thioglycerol, (alpha] monothioglycerol, and sodium thio sulfate; low molecular weight proteins, such as human serum albumin, bovine serum albumin, gelatin, or other immunoglobulins; and hydrophilic polymers, such as polyvinylpyrrolidone. Such formulations may be used for continuous administrations 25 which may be intravenuous or subcutaneous with and/or without pump systems. Amino acids may be charged amino acids, preferably lysine, lysine acetate, arginine, glutamate and/or histidine. Surfactants may be detergents, preferably with a molecular weight of >1.2 KD and/or a polyether, preferably with a molecular weight of >3 KD. Non-limiting examples for preferred detergents are Tween 20, Tween 40, Tween 60, Tween 80 or Tween 85. Non-limiting examples 30 for preferred polyethers are PEG 3000, PEG 3350, PEG 4000 or PEG 5000. Buffer systems used in the present invention can have a preferred pH of 5-9 and may comprise citrate, succinate, phosphate, histidine and acetate. The compositions of the present invention can be administered to the subject at a suitable dose 35 which can be determined e.g. by dose escalating studies by administration of increasing doses 50 of the polypeptide of the invention exhibiting cross-species specificity described herein to non chimpanzee primates, for instance macaques. As set forth above, the binding molecule of the invention exhibiting cross-species specificity described herein can be advantageously used in identical form in preclinical testing in non-chimpanzee primates and as drug in humans. These 5 compositions can also be administered in combination with other proteinaceous and non proteinaceous drugs. These drugs may be administered simultaneously with the composition comprising the polypeptide of the invention as defined herein or separately before or after administration of said polypeptide in timely defined intervals and doses. The dosage regimen will be determined by the attending physician and clinical factors. As is well known in the 10 medical arts, dosages for any one patient depend upon many factors, including the patient's size, body surface area, age, the particular compound to be administered, sex, time and route of administration, general health, and other drugs being administered concurrently. Preparations for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions, and emulsions. Examples of non-aqueous solvents are propylene glycol, 15 polyethylene glycol, vegetable oils such as olive oil, and injectable organic esters such as ethyl oleate. Aqueous carriers include water, alcoholic/aqueous solutions, emulsions or suspensions, including saline and buffered media. Parenteral vehicles include sodium chloride solution, Ringer's dextrose, dextrose and sodium chloride, lactated Ringer's, or fixed oils. Intravenous vehicles include fluid and nutrient replenishers, electrolyte replenishers (such as those based on 20 Ringer's dextrose), and the like. Preservatives and other additives may also be present such as, for example, antimicrobials, anti-oxidants, chelating agents, inert gases and the like. In addition, the composition of the present invention might comprise proteinaceous carriers, like, e.g., serum albumin or immunoglobulin, preferably of human origin. It is envisaged that the composition of the invention might comprise, in addition to the polypeptide of the invention 25 defined herein, further biologically active agents, depending on the intended use of the composition. Such agents might be drugs acting on the gastro-intestinal system, drugs acting as cytostatica, drugs preventing hyperurikemia, drugs inhibiting immunoreactions (e.g. corticosteroids), drugs modulating the inflammatory response, drugs acting on the circulatory system and/or agents such as cytokines known in the art. It is also envisaged that the binding 30 molecule of the present invention is applied in a co-therapy, i.e., in combination with another anti-cancer medicament. The biological activity of the pharmaceutical composition defined herein can be determined for instance by cytotoxicity assays, as described in the following examples, in WO 99/54440 or by 35 Schlereth et al. (Cancer Immunol. Immunother. 20 (2005), 1-12). "Efficacy" or "in vivo efficacy" 51 as used herein refers to the response to therapy by the pharmaceutical composition of the invention, using e.g. standardized NCI response criteria. The success or in vivo efficacy of the therapy using a pharmaceutical composition of the invention refers to the effectiveness of the composition for its intended purpose, i.e. the ability of the composition to cause its desired 5 effect, i.e. depletion of pathologic cells, e.g. tumor cells. The in vivo efficacy may be monitored by established standard methods for the respective disease entities including, but not limited to white blood cell counts, differentials, Fluorescence Activated Cell Sorting, bone marrow aspiration. In addition, various disease specific clinical chemistry parameters and other established standard methods may be used. Furthermore, computer-aided tomography, X-ray, 10 nuclear magnetic resonance tomography (e.g. for National Cancer Institute-criteria based response assessment [Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM, Lister TA, Vose J, Grillo-Lopez A, Hagenbeek A, Cabanillas F, Klippensten D, Hiddemann W, Castellino R, Harris NL, Armitage JO, Carter W, Hoppe R, Canellos GP. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI 15 Sponsored International Working Group. J Clin Oncol. 1999 Apr;17(4):1244]), positron-emission tomography scanning, white blood cell counts, differentials, Fluorescence Activated Cell Sorting, bone marrow aspiration, lymph node biopsies/histologies, and various lymphoma specific clinical chemistry parameters (e.g. lactate dehydrogenase) and other established standard methods may be used. 20 Another major challenge in the development of drugs such as the pharmaceutical composition of the invention is the predictable modulation of pharmacokinetic properties. To this end, a pharmacokinetic profile of the drug candidate, i.e. a profile of the pharmacokinetic parameters that affect the ability of a particular drug to treat a given condition, can be established. 25 Pharmacokinetic parameters of the drug influencing the ability of a drug for treating a certain disease entity include, but are not limited to: half-life, volume of distribution, hepatic first-pass metabolism and the degree of blood serum binding. The efficacy of a given drug agent can be influenced by each of the parameters mentioned above. 30 "Half-life" means the time where 50% of an administered drug are eliminated through biological processes, e.g. metabolism, excretion, etc. By "hepatic first-pass metabolism" is meant the propensity of a drug to be metabolized upon first contact with the liver, i.e. during its first pass through the liver. 35 52 "Volume of distribution" means the degree of retention of a drug throughout the various compartments of the body, like e.g. intracellular and extracellular spaces, tissues and organs, etc. and the distribution of the drug within these compartments. 5 "Degree of blood serum binding" means the propensity of a drug to interact with and bind to blood serum proteins, such as albumin, leading to a reduction or loss of biological activity of the drug. Pharmacokinetic parameters also include bioavailability, lag time (Tlag), Tmax, absorption 10 rates, more onset and/or Cmax for a given amount of drug administered. "Bioavailability" means the amount of a drug in the blood compartment. "Lag time" means the time delay between the administration of the drug and its detection and measurability in blood or plasma. "Tmax" is the time after which maximal blood concentration of the drug is reached, and "Cmax" 15 is the blood concentration maximally obtained with a given drug. The time to reach a blood or tissue concentration of the drug which is required for its biological effect is influenced by all parameters. Pharmacokinetic parameters of bispecific single chain antibodies exhibiting cross species specificity, which may be determined in preclinical animal testing in non-chimpanzee primates as outlined above, are also set forth e.g. in the publication by Schlereth et al. (Cancer 20 Immunol. Immunother. 20 (2005), 1-12). The term "toxicity" as used herein refers to the toxic effects of a drug manifested in adverse events or severe adverse events. These side events might refer to a lack of tolerability of the drug in general and/or a lack of local tolerance after administration. Toxicity could also include 25 teratogenic or carcinogenic effects caused by the drug. The term "safety", "in vivo safety" or "tolerability" as used herein defines the administration of a drug without inducing severe adverse events directly after administration (local tolerance) and during a longer period of application of the drug. "Safety", "in vivo safety" or "tolerability" can be 30 evaluated e.g. at regular intervals during the treatment and follow-up period. Measurements include clinical evaluation, e.g. organ manifestations, and screening of laboratory abnormalities. Clinical evaluation may be carried out and deviations to normal findings recorded/coded according to NCI-CTC and/or MedDRA standards. Organ manifestations may include criteria such as allergy/immunology, blood/bone marrow, cardiac arrhythmia, coagulation and the like, 35 as set forth e.g. in the Common Terminology Criteria for adverse events v3.0 (CTCAE). 53 Laboratory parameters which may be tested include for instance hematology, clinical chemistry, coagulation profile and urine analysis and examination of other body fluids such as serum, plasma, lymphoid or spinal fluid, liquor and the like. Safety can thus be assessed e.g. by physical examination, imaging techniques (i.e. ultrasound, x-ray, CT scans, Magnetic 5 Resonance Imaging (MRI), other measures with technical devices (i.e. electrocardiogram), vital signs, by measuring laboratory parameters and recording adverse events. For example, adverse events in non-chimpanzee primates in the uses and methods according to the invention may be examined by histopathological and/or histochemical methods. 10 The term "effective dose" or "effective dosage" is defined as an amount sufficient to achieve or at least partially achieve the desired effect. The term "therapeutically effective dose" is defined as an amount sufficient to cure or at least partially arrest the disease and its complications in a patient already suffering from the disease. Amounts effective for this use will depend upon the severity of the infection and the general state of the subject's own immune system. The term 15 "patient" includes human and other mammalian subjects that receive either prophylactic or therapeutic treatment. The term "effective and non-toxic dose" as used herein refers to a tolerable dose of an inventive binding molecule which is high enough to cause depletion of pathologic cells, tumor elimination, 20 tumor shrinkage or stabilization of disease without or essentially without major toxic effects. Such effective and non-toxic doses may be determined e.g. by dose escalation studies described in the art and should be below the dose inducing severe adverse side events (dose limiting toxicity, DLT). 25 The above terms are also referred to e.g. in the Preclinical safety evaluation of biotechnology derived pharmaceuticals S6; ICH Harmonised Tripartite Guideline; ICH Steering Committee meeting on July 16, 1997. The appropriate dosage, or therapeutically effective amount, of the binding molecule of the 30 invention will depend on the condition to be treated, the severity of the condition, prior therapy, and the patient's clinical history and response to the therapeutic agent. The proper dose can be adjusted according to the judgment of the attending physician such that it can be administered to the patient one time or over a series of administrations. The pharmaceutical composition can be administered as a sole therapeutic or in combination with additional therapies such as anti 35 cancer therapies as needed. 54 The pharmaceutical compositions of this invention are particularly useful for parenteral administration, i.e., subcutaneously, intramuscularly, intravenously, intra-articular and/or intra synovial. Parenteral administration can be by bolus injection or continuous infusion. 5 If the pharmaceutical composition has been lyophilized, the lyophilized material is first reconstituted in an appropriate liquid prior to administration. The lyophilized material may be reconstituted in, e.g., bacteriostatic water for injection (BWFI), physiological saline, phosphate buffered saline (PBS), or the same formulation the protein had been in prior to lyophilization. 10 Preferably, the binding molecule of the invention or produced by a process of the invention is used in the prevention, treatment or amelioration of a disease selected from a proliferative disease, a tumorous disease, or an immunological disorder. An alternative embodiment of the invention provides a method for the prevention, treatment or 15 amelioration of a disease selected from a proliferative disease, a tumorous disease, or an immunological disorder comprising the step of administering to a patient in the need thereof the binding molecule of the invention or produced by a process of the invention. The formulations described herein are useful as pharmaceutical compositions in the treatment, 20 amelioration and/or prevention of the pathological medical condition as described herein in a patient in need thereof. The term "treatment" refers to both therapeutic treatment and prophylactic or preventative measures. Treatment includes the application or administration of the formulation to the body, an isolated tissue, or cell from a patient who has a disease/disorder, a symptom of a disease/disorder, or a predisposition toward a disease/disorder, with the 25 purpose to cure, heal, alleviate, relieve, alter, remedy, ameliorate, improve, or affect the disease, the symptom of the disease, or the predisposition toward the disease. Those "in need of treatment" include those already with the disorder, as well as those in which the disorder is to be prevented. The term "disease" is any condition that would benefit from 30 treatment with the protein formulation described herein. This includes chronic and acute disorders or diseases including those pathological conditions that predispose the mammal to the disease in question. Non-limiting examples of diseases/disorders to be treated herein include proliferative disease, a tumorous disease, or an immunological disorder. 55 Preferably, the binding molecule of the invention is for use in the prevention, treatment or amelioration of B cell disorders that correlate with BCMA (over)expression such as plasma cell disorders, and/or autoimmune diseases. The autoimmune disease is, for example, systemic lupus erythematodes or rheumatoid arthritis. 5 Also provided by the present invention is a method for the treatment or amelioration of B cell disorders that correlate with BCMA (over)expression such as plasma cell disorders, and/or autoimmune diseases, comprising the step of administering to a subject in need thereof the binding molecule of the invention. The autoimmune disease is, for example, systemic lupus 10 erythematodes or rheumatoid arthritis. In plasma cell disorders, one clone of plasma cells multiplies uncontrollably. As a result, this clone produces vast amounts of a single (monoclonal) antibody known as the M-protein. In some cases, such as with monoclonal gammopathies, the antibody produced is incomplete, consisting of only light chains or heavy chains. These abnormal plasma cells and the antibodies 15 they produce are usually limited to one type. Preferably, the plasma cell disorder is selected from the group consisting of multiple myeloma, plasmacytoma, plasma cell leukemia, macroglobulinemia, amyloidosis, Waldenstrom's macroglobulinemia, solitary bone plasmacytoma, extramedullary plasmacytoma, osteosclerotic myeloma, heavy chain diseases, monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma. 20 In another aspect, kits are provided comprising a binding molecule of the invention, a nucleic acid molecule of the invention, a vector of the invention, or a host cell of the invention. The kit may comprise one or more vials containing the binding molecule and instructions for use. The kit may also contain means for administering the binding molecule of the present invention such 25 as a syringe, pump, infuser or the like, means for reconstituting the binding molecule of the invention and/or means for diluting the binding molecule of the invention. Furthermore, the present invention relates to the use of epitope cluster 3 of BCMA, preferably human BCMA, for the generation of a binding molecule, preferably an antibody, which is 30 capable of binding to BCMA, preferably human BCMA. The epitope cluster 3 of BCMA preferably corresponds to amino acid residues 24 to 41 of the sequence as depicted in SEQ ID NO: 1002. 56 In addition, the present invention provides a method for the generation of an antibody, preferably a bispecific binding molecule, which is capable of binding to BCMA, preferably human BCMA, comprising (a) immunizing an animal with a polypeptide comprising epitope cluster 3 of BCMA, 5 preferably human BCMA, wherein epitope cluster 3 of BCMA corresponds to amino acid residues 24 to 41 of the sequence as depicted in SEQ ID NO: 1002, (b) obtaining said antibody, and (c) optionally converting said antibody into a bispecific binding molecule which is capable of binding to human BCMA and preferably to the T cell CD3 receptor complex. 10 Preferably, step (b) includes that the obtained antibody is tested as follows: when the respective epitope cluster in the human BCMA protein is exchanged with the respective epitope cluster of a murine BCMA antigen (resulting in a construct comprising human BCMA, wherein human epitope cluster 3 is replaced with murine epitope cluster 3; see SEQ ID NO: 1011), a decrease in the binding of the antibody will occur. Said decrease is preferably at 15 least 10%, 20%, 30%, 40%, 50%; more preferably at least 60%, 70%, 80%, 90%, 95% or even 100% in comparison to the respective epitope cluster in the human BCMA protein, whereby binding to the respective epitope cluster in the human BCMA protein is set to be 100%. It is envisaged that the aforementioned human BCMA/murine BCMA chimeras are expressed in CHO cells. It is also envisaged that the human BCMA/murine BCMA chimeras are fused with a 20 transmembrane domain and/or cytoplasmic domain of a different membrane-bound protein such as EpCAM; see Figure 2a. A method to test this loss of binding due to exchange with the respective epitope cluster of a non-human (e.g. murine) BCMA antigen is described in the appended Examples, in particular in Examples 1-3. 25 The method may further include testing as to whether the antibody binds to epitope cluster 3 of human BCMA and is further capable of binding to epitope cluster 3 of macaque BCMA such as BCMA from Macaca mulatta (SEQ ID NO:1017) or Macaca fascicularis (SEQ ID NO:1017). The present invention also provides binding molecules comprising any one of the amino acid 30 sequences shown in SEQ ID NOs: 1-1000 and 1022-1093. Preferably, a binding molecule comprises three VH CDR sequences (named "VH CDR1", "VH CDR2", "VH CDR3", see 4 1h column of the appended Sequence Table) from a binding molecule termed "BCMA-(X)", wherein X is 1-100 (see 2" column of the appended Sequence Table) and/or three VL CDR sequences (named "VL CDR1", "VH CDR2", "VH CDR3", see 4t' column 57 of the appended Sequence Table) from a binding molecule term BCMA-X, wherein X is 1-100 (see 2 nd column of the appended Sequence Table). Preferably, a binding molecule comprises a VH and/or VL sequence as is given in the appended Sequence Table (see 4* column of the appended Sequence Table: "VH" and "VL"). 5 Preferably, a binding molecule comprises a scFV sequence as is given in the appended Sequence Table (see 4 th column of the appended Sequence Table: "scFv"). Preferably, a binding molecule comprises a bispecific molecule sequence as is given in the appended Sequence Table (see 4 th column of the appended Sequence Table: "bispecific molecule"). 10 The present invention also relates to a bispecific binding agent comprising at least two binding domains, comprising a first binding domain and a second binding domain, wherein said first binding domain binds to the B cell maturation antigen BCMA and wherein said second binding domain binds to CD3 (item 1) also including the following items: 15 Item 2. The bispecific binding agent of item 1, wherein said first binding domain binds to the extracellular domain of BCMA and said second binding domain binds to the E chain of CD3. Item 3. A bispecific binding agent of item 1 or 2 which is in the format of a full-length antibody or 20 an antibody fragment. Item 4. A bispecific binding agent of item 3 in the format of a full-length antibody, wherein said first BCMA-binding domain is derived from mouse said and wherein said second CD3 binding domain is derived from rat. 25 Item 5. A bispecific binding agent of item 3, which is in the format of an antibody fragment in the form of a diabody that comprises a heavy chain variable domain connected to a light chain variable domain on the same polypeptide chain such that the two domains do not pair. 30 Item 6. A bispecific binding agent of item 1 or 2 which is in the format of a bispecific single chain antibody that consists of two scFv molecules connected via a linker peptide or by a human serum albumin molecule. 58 Item 7. The bispecific binding agent of item 6, heavy chain regions (VH) and the corresponding variable light chain regions (VL) are arranged, from N-terminus to C-terminus, in the order VH(BCMA)-VL(BCMA) -VH(CD3)-VL(CD3), 5 VH(CD3)-VL(CD3) -VH(BCMA)-VL(BCMA) or VH CD3)-VL(CD3)-VL(BCMA)-VH(BCMA). Item 8. A bispecific binding agent of item 1 or 2, which is in the format of a single domain immunoglobulin domain selected from VHHs or VHs. 10 Item 9. The bispecific binding agent of item 1 or 2, which is in the format of an Fv molecule that has four antibody variable domains with at least two binding domains, wherein at least one binding domain is specific to human BCMA and at least one binding domain is specific to human CD3. 15 Item 10. A bispecific binding agent of item 1 or 2, which is in the format of a single-chain binding molecule consisting of a first binding domain specific for BCMA, a constant sub region that is located C-terminal to said first binding domain, a scorpion linker located C terminal to the constant sub-region, and a second binding domain specific for CD3, 20 which is located C-terminal to said constant sub-region. Item 11. The bispecific binding agent of item 1 or 2, which is in the format of an antibody like molecule that binds to BCMA via the two heavy chain/light chain Fv of an antibody or an antibody fragment and which binds to CD3 via a binding domain that has been 25 engineered into non-CDR loops of the heavy chain or the light chain of said antibody or antibody fragment. Item 12. A bispecific binding agent of item 1 which is in the format of a bispecific ankyrin repeat molecule. 30 Item 13. A bispecific binding agent of item 1, wherein said first binding domain has a format selected from the formats defined in any one of items 3 to 12 and wherein said second binding domain has a different format selected from the formats defined in any one of items 3 to 12. 35 59 Item 14. A bispecific binding agent of item 1 which is a bicyclic peptide. Item 15. A pharmaceutical composition containing at least one bispecific binding agent of any one of items 1 to 14. 5 Item 16. A bispecific binding agent of any one of items 1 to 14 or a pharmaceutical composition of item 14 for the treatment of plasma cell disorders or other B cell disorders that correlate with BCMA expression and for the treatment of autoimmune diseases. 10 Item 17. A bispecific binding agent of any one of items 1 to 14 or a pharmaceutical composition of item 15 for the treatment of plasma cell disorders selected from plasmacytoma, plasma cell leukemia, multiple myeloma, macroglobulinemia, amyloidosis, Waldenstrom's macroglobulinemia , solitary bone plasmacytoma, extramedullary plasmacytoma, osteosclerotic myeloma, heavy chain diseases, 15 monoclonal gammopathy of undetermined significance, smoldering multiple myeloma. Variations of the above items are derivable from EP 10 191 418.2 which are also included herein. It should be understood that the inventions herein are not limited to particular methodology, 20 protocols, or reagents, as such can vary. The discussion and examples provided herein are presented for the purpose of describing particular embodiments only and are not intended to limit the scope of the present invention, which is defined solely by the claims. All publications and patents cited throughout the text of this specification (including all patents, patent applications, scientific publications, manufacturer's specifications, instructions, etc.), 25 whether supra or infra, are hereby incorporated by reference in their entirety. Nothing herein is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention. To the extent the material incorporated by reference contradicts or is inconsistent with this specification, the specification will supersede any such material. 30 60 The Figures show: Figure 1: Sequence alignment of the extracellular domain (ECD) of human BCMA (amino acid residues 1 54 of the full-length protein) and murine BCMA (amino acid residues 1-49 of the full-length 5 protein). Highlighted are the regions (domains or amino acid residues) which were exchanged in the chimeric constructs, as designated for the epitope clustering. Cysteines are depicted by black boxes. Disulfide bonds are indicated. Figure 2: 10 Epitope mapping of the BCMA constructs. Human and murine BCMA (figure 2a) as well as seven chimeric human-murine BCMA constructs (figure 2b) expressed on the surface of CHO cells as shown by flow cytometry. The expression of human BCMA on CHO was detected with a monoclonal anti-human BCMA antibody. Murine BCMA expression was detected with a monoclonal anti-murine BCMA-antibody. Bound monoclonal antibody was detected with an anti 15 rat IgG-Fc-gamma-specific antibody conjugated to phycoerythrin. Figure 3: Examples of binding molecules specific for epitope cluster E3, as detected by epitope mapping of the chimeric BCMA constructs (see example 3). 20 Figure 4: Determination of binding constants of bispecific binding molecules (anti BCMA x anti CD3) on human and macaque BCMA using the Biacore system. Antigen was immobilized in low to intermediate density (100 RU) on CM5 chip. Dilutions of binders were floated over the chip 25 surface and binding determined using BiaEval Software. Respective off-rates and the binding constant (KD) of the respective binders are depicted below every graph. Figure 5: Cytotoxic activity of BCMA bispecific antibodies as measured in an 18-hour 51 chromium release 30 assay. Effector cells: stimulated enriched human CD8 T cells. Target cells: Human BCMA transfected CHO cells (left figure) and macaque BCMA transfected CHO cells (right figure). Effector to target cell (E:T) ratio: 10:1. Figure 6: 61 Determination of binding constants of BCMA/CD3 bispecific antibodies of epitope cluster E3 on human and macaque BCMA and on human and macaque CD3 using the Biacore system. Antigen was immobilized in low to intermediate density (100-200 RU) on CM5 chip. Dilutions of bispecific antibodies were floated over the chip surface and binding determined using BiaEval 5 Software. Respective on- and off-rates and the resulting binding constant (KD) of the respective bispecific antibodies are depicted below every graph. Figure 7: FACS analysis of BCMA/CD3 bispecific antibodies of epitope cluster E3 on indicated cell lines: 10 1) human BCMA transfected CHO cells, 2) human CD3 positive human T cell line HBP-ALL, 3) macaque BCMA transfected CHO cells, 4) macaque T cell line 4119 LnPx , 5) BCMA-positive human multiple myeloma cell line NCI-H929 and 6) untransfected CHO cells. Negative controls [1) to 6)]: detection antibodies without prior BCMA/CD3 bispecific antibody. 15 Figure 8: Scatchard analysis of BCMA/CD3 bispecific antibodies on BCMA-expressing cells. Cells were incubated with increasing concentrations of monomeric antibody until saturation. Antibodies were detected by flow cytometry. Values of triplicate measurements were plotted as hyperbolic curves and as sigmoid curves to demonstrate a valid concentration range used. Maximal 20 binding was determined using Scatchard evaluation, and the respective KD values were calculated. Figure 9: Cytotoxic activity of BCMA/CD3 bispecific antibodies of epitope cluster E3, as measured in an 25 18-hour 51-chromium release assay against CHO cells transfected with human BCMA. Effector cells: stimulated enriched human CD8 T cells. Effector to target cell (E:T) ratio: 10:1. Figure 10: Cytotoxic activity of BCMA/CD3 bispecific antibodies of epitope cluster E3 as measured in a 48 30 hour FACS-based cytotoxicity assay. Effector cells: unstimulated human PBMC. Target cells: CHO cells transfected with human BCMA. Effector to target cell (E:T)-ratio: 10:1. Figure 11: 62 FACS analysis of BCMA/CD3 bispecific antibodies of epitope cluster E3 on BAFF-R and TACI transfected CHO cells. Cell lines: 1) human BAFF-R transfected CHO cells, 2) human TACI transfected CHO cells 3) multiple myeloma cell line L363; negative controls: detection antibodies without prior BCMA/CD3 bispecific antibody. Positive contols: BAFF-R detection: 5 goat anti hu BAFF-R (R&D AF1 162; 1:20) detected by anti-goat antibody-PE (Jackson 705-116 147; 1:50) TACI-detection: rabbit anti TACI antibody (abcam AB 79023; 1:100) detected by goat anti rabbit-antibody PE (Sigma P9757; 1:20). Figure 12: 10 Cytotoxic activity of BCMA/CD3 bispecific antibodies as measured in an 18-hour 51-chromium release assay. Effector cells: stimulated enriched human CD8 T cells. Target cells: BCMA positive human multiple myeloma cell line L363 (i.e. natural expresser). Effector to target cell (E:T) ratio: 10:1. 15 Figure 13: Cytotoxic activity of BCMA/CD3 bispecific antibodies as measured in a 48-hour FACS-based cytotoxicity assay. Effector cells: unstimulated human PBMC. Target cells: human multiple myeloma cell line L363 (natural BCMA expresser). Effector to target cell (E:T)-ratio: 10:1. 20 Figure 14: Cytotoxic activity of BCMA/CD3 bispecific antibodies as measured in a 48-hour FACS-based cytotoxicity assay. Effector cells: unstimulated human PBMC. Target cells: BCMA-positive human multiple myeloma cell line NCI-H929. Effector to target cell (E:T)-ratio: 10:1. 25 Figure 15: Cytotoxic activity of BCMA/CD3 bispecific antibodies as measured in a 48-hour FACS-based cytotoxicity assay. Effector cells: macaque T cell line 4119LnPx. Target cells: CHO cells transfected with macaque BCMA. Effector to target cell (E:T) ratio: 10:1. 30 Figure 16: Anti-tumor activity of BCMA/CD3 bispecific antibodies of epitope cluster E3 in an advanced stage NCI-H929 xenograft model (see Example 16). Figure 17: 63 FACS-based cytotoxicity assay using human multiple myeloma cell lines NCI-H929, L-363 and OPM-2 as target cells and human PBMC as effector cells (48h; E:T = 10:1). The figure depicts the cytokine levels [pg/ml] which were determined for 11-2, IL-6, IL-10, TNF and IFN-gamma at increasing concentrations of the BCMA/CD3 bispecific antibodies of epitope cluster E3 (see 5 Example 22). 64 Examples: The following examples illustrate the invention. These examples should not be construed as to limit the scope of this invention. The examples are included for purposes of illustration, and the present invention is limited only by the claims. 5 Example I Generation of CHO cells expressing chimeric BCMA For the construction of the chimeric epitope mapping molecules, the amino acid sequence of the respective epitope domains or the single amino acid residue of human BCMA was changed 10 to the murine sequence. The following molecules were constructed: * Human BCMA ECD / El murine (SEQ ID NO: 1009) Chimeric extracellular BCMA domain: Human extracellular BCMA domain wherein epitope cluster 1 (amino acid residues 1-7 of SEQ ID NO: 1002 or 1007) is replaced by the respective 15 murine cluster (amino acid residues 1-4 of SEQ ID NO: 1004 or 1008) + deletion of amino acid residues 1-3 and G6Q mutation in SEQ ID NO: 1002 or 1007 * Human BCMA ECD / E2 murine (SEQ ID NO: 1010) Chimeric extracellular BCMA domain: Human extracellular BCMA domain wherein epitope 20 cluster 2 (amino acid residues 8-21 of SEQ ID NO: 1002 or 1007) is replaced by the respective murine cluster (amino acid residues 5-18 of SEQ ID NO: 1004 or 1008) + S9F, Q1OH, and N11 S mutations in SEQ ID NO: 1002 or 1007 * Human BCMA ECD /E3 murine (SEQ ID NO: 1011) 25 Chimeric extracellular BCMA domain: Human extracellular BCMA domain wherein epitope cluster 3 (amino acid residues 24-41 of SEQ ID NO: 1002 or 1007) is replaced by the respective murine cluster (amino acid residues 21-36 of SEQ ID NO: 1004 or 1008) + deletion of amino acid residues 31 and 32 and Q25H, S30N, L35A, and R39P mutation in SEQ ID NO: 1002 or 1007 30 * Human BCMA ECD / E4 murine (SEQ ID NO: 1012) Chimeric extracellular BCMA domain: Human extracellular BCMA domain wherein epitope cluster 4 (amino acid residues 42-54 of SEQ ID NO: 1002 or 1007) is replaced by the respective murine cluster (amino acid residues 37-49 of SEQ ID NO: 1004 or 1008) 35 + N42D, A43P, N47S, N53Y and A54T mutations in SEQ ID NO: 1002 or 1007 65 * Human BCMA ECD / E5 murine (SEQ ID NO: 1013) Chimeric extracellular BCMA domain: Human extracellular BCMA domain wherein the amino acid residue at position 22 of SEQ ID NO: 1002 or 1007 (isoleucine) is replaced by its 5 respective murine amino acid residue of SEQ ID NO: 1004 or 1008 (lysine, position 19) + 122K mutation in SEQ ID NO: 1002 or 1007 * Human BCMA ECD / E6 murine (SEQ ID NO: 1014) Chimeric extracellular BCMA domain: Human extracellular BCMA domain wherein the amino 10 acid residue at position 25 of SEQ ID NO: 1002 or 1007 (glutamine) is replaced by its respective murine amino acid residue of SEQ ID NO: 1004 or 1008 (histidine, position 22) 4 Q25H mutation in SEQ ID NO: 1002 or 1007 * Human BCMA ECD / E7 murine (SEQ ID NO: 1015) 15 Chimeric extracellular BCMA domain: Human extracellular BCMA domain wherein the amino acid residue at position 39 of SEQ ID NO: 1002 or 1007 (arginine) is replaced by its respective murine amino acid residue of SEQ ID NO: 1004 or 1008 (proline, position 34) 4 R39P mutation in SEQ ID NO: 1002 or 1007 20 A) The cDNA constructs were cloned into the mammalian expression vector pEF-DHFR and stably transfected into CHO cells. The expression of human BCMA on CHO cells was verified in a FACS assay using a monoclonal anti-human BCMA antibody. Murine BCMA expression was demonstrated with a monoclonal anti-mouse BCMA-antibody. The used concentration of the BCMA antibodies was 10 pg/ml inPBS/2%FCS. Bound monoclonal antibodies were detected 25 with an anti-rat-IgG-Fcy-PE (1:100 in PBS/2%FCS; Jackson-Immuno-Research #112-116-071). As negative control, cells were incubated with PBS/2% FCS instead of the first antibody. The samples were measured by flow cytometry on a FACSCanto II instrument (Becton Dickinson) and analyzed by FlowJo software (Version 7.6). The surface expression of human-murine BCMA chimeras, transfected CHO cells were analyzed and confirmed in a flow cytometry assay 30 with different anti-BCMA antibodies (Figure 2). B) For the generation of CHO cells expressing human, macaque, mouse and human/mouse chimeric transmembrane BCMA, the coding sequences of human, macaque, mouse BCMA and the human-mouse BCMA chimeras (BCMA sequences as published in GenBank, accession 35 numbers NM_001192 [human]; NM_011608 [mouse] and XM_001106892 [macaque]) were 66 obtained by gene synthesis according to standard protocols. The gene synthesis fragments were designed as to contain first a Kozak site for eukaryotic expression of the constructs and the coding sequence of a 19 amino acid immunoglobulin leader peptide, followed in frame by the coding sequence of the BCMA proteins respectively in case of the chimeras with the 5 respective epitope domains of the human sequence exchanged for the murine sequence. Except for the human BCMA ECD / E4 murine and human BCMA constructs the coding sequence of the extracellular domain of the BCMA proteins was followed in frame by the coding sequence of an artificial Serl-Gly4-Serl-linker followed by the intracellular domain of human 10 EpCAM (amino acids 226-314; sequence as published in GenBank accession number NM_002354). All coding sequences were followed by a stop codon. The gene synthesis fragments were also designed as to introduce suitable restriction sites. The gene synthesis fragments were cloned 15 into a plasmid designated pEF-DHFR (pEF-DHFR is described in Raum et al. Cancer Immunol Immunother 50 (2001) 141-150). All aforementioned procedures were carried out according to standard protocols (Sambrook, Molecular Cloning; A Laboratory Manual, 3rd edition, Cold Spring Harbour Laboratory Press, Cold Spring Harbour, New York (2001)). For each antigen a clone with sequence-verified nucleotide sequence was transfected into DHFR deficient CHO 20 cells for eukaryotic expression of the constructs. Eukaryotic protein expression in DHFR deficient CHO cells was performed as described by Kaufman R.J. (1990) Methods Enzymol. 185, 537-566. Gene amplification of the constructs was induced by increasing concentrations of methotrexate (MTX) to a final concentration of up to 20 nM MTX. 25 Example 2 2.1 Transient expression in HEK 293 cells Clones of the expression plasmids with sequence-verified nucleotide sequences were used for transfection and protein expression in the FreeStyle 293 Expression System (Invitrogen GmbH, 30 Karlsruhe, Germany) according to the manufacturer's protocol. Supernatants containing the expressed proteins were obtained, cells were removed by centrifugation and the supernatants were stored at -20 C. 2.2 Stable expression in CHO cells 67 Clones of the expression plasmids with sequence-verified nucleotide sequences were transfected into DHFR deficient CHO cells for eukaryotic expression of the constructs. Eukaryotic protein expression in DHFR deficient CHO cells was performed as described by Kaufman R.J. (1990) Methods Enzymol. 185, 537-566. Gene amplification of the constructs was 5 induced by increasing concentrations of methotrexate (MTX) to a final concentration of 20 nM MTX. After two passages of stationary culture the cells were grown in roller bottles with nucleoside-free HyQ PF CHO liquid soy medium (with 4.0 mM L-Glutamine with 0.1 % Pluronic F - 68; HyClone) for 7 days before harvest. The cells were removed by centrifugation and the supernatant containing the expressed protein was stored at -20 C. 10 2.3 Protein purification Purification of soluble BCMA proteins was performed as follows: Akta@ Explorer System (GE Healthcare) and Unicorn@ Software were used for chromatography. Immobilized metal affinity chromatography ("IMAC") was performed using a Fractogel EMD chelate@ (Merck) which was 15 loaded with ZnC12 according to the protocol provided by the manufacturer. The column was equilibrated with buffer A (20 mM sodium phosphate buffer pH 7.2, 0.1 M NaCI) and the filtrated (0.2 pm) cell culture supernatant was applied to the column (10 ml) at a flow rate of 3 ml/min. The column was washed with buffer A to remove unbound sample. Bound protein was eluted using a two-step gradient of buffer B (20 mM sodium phosphate buffer pH 7.2, 0.1 M NaCl, 0.5 20 M imidazole) according to the following procedure: Step 1: 10 % buffer B in 6 column volumes Step 2: 100 % buffer B in 6 column volumes Eluted protein fractions from step 2 were pooled for further purification. All chemicals were of research grade and purchased from Sigma (Deisenhofen) or Merck (Darmstadt). 25 Gel filtration chromatography was performed on a HiLoad 16/60 Superdex 200 prep grade column (GE/Amersham) equilibrated with Equi-buffer (10 mM citrate, 25 mM lysine-HCI, pH 7.2 for proteins expressed in HEK cells and PBS pH 7.4 for proteins expressed in CHO cells). Eluted protein samples (flow rate 1 ml/min) were subjected to standard SDS-PAGE and Western Blot for detection. Protein concentrations were determined using OD280 nm. 30 Proteins obtained via transient expression in HEK 293 cells were used for immunizations. Proteins obtained via stable expression in CHO cells were used for selection of binders and for measurement of binding. Example 3 35 Epitope clustering of murine scFv-fragments 68 Cells transfected with human or murine BCMA, or with chimeric BCMA molecules were stained with crude, undiluted periplasmic extract containing scFv binding to human/macaque BCMA. Bound scFv were detected with 1 pg/mI of an anti-FLAG antibody (Sigma F1804) and a R-PE labeled anti-mouse Fc gamma-specific antibody (1:100; Dianova #115-116-071). All antibodies 5 were diluted in PBS with 2% FCS. As negative control, cells were incubated with PBS/2% FCS instead of the periplasmic extract. The samples were measured by flow cytometry on a FACSCanto 11 instrument (Becton Dickinson) and analyzed by FlowJo software (Version 7.6); see Figure 3. 10 Example 4 Procurement of different recombinant forms of soluble human and macaque BCMA A) The coding sequences of human and rhesus BCMA (as published in GenBank, accession numbers NM_001192 [human], XM_001106892 [rhesus]) coding sequences of human albumin, human Fcyl and murine albumin were used for the construction of artificial cDNA sequences 15 encoding soluble fusion proteins of human and macaque BCMA respectively and human albumin, human IgG1 Fc and murine albumin respectively as well as soluble proteins comprising only the extracellular domains of BCMA. To generate the constructs for expression of the soluble human and macaque BCMA proteins, cDNA fragments were obtained by PCR mutagenesis of the full-length BCMA cDNAs described above and molecular cloning according 20 to standard protocols. For the fusions with human albumin, the modified cDNA fragments were designed as to contain first a Kozak site for eukaryotic expression of the constructs followed by the coding sequence of the human and rhesus (or Macaca mulatta) BCMA proteins respectively, comprising amino acids 1 to 54 and 1 to 53 corresponding to the extracellular domain of human and rhesus 25 BCMA, respectively, followed in frame by the coding sequence of an artificial Serl-Gly4-Serl linker, followed in frame by the coding sequence of human serum albumin, followed in frame by the coding sequence of a Flag tag, followed in frame by the coding sequence of a modified histidine tag (SGHHGGHHGGHH) and a stop codon. For the fusions with murine IgG1, the modified cDNA fragments were designed as to contain 30 first a Kozak site for eukaryotic expression of the constructs followed by the coding sequence of the human and macaque BCMA proteins respectively, comprising amino acids 1 to 54 and 1 to 53 corresponding to the extracellular domain of human and rhesus BCMA, respectively, followed in frame by the coding sequence of an artificial Serl-Gly4-Serl-linker, followed in frame by the coding sequence of the hinge and Fc gamma portion of human IgG1, followed in 35 frame by the coding sequence of a hexahistidine tag and a stop codon. 69 For the fusions with murine albumin, the modified cDNA fragments were designed as to contain first a Kozak site for eukaryotic expression of the constructs followed by the coding sequence of the human and macaque BCMA proteins respectively, comprising amino acids 1 to 54 and 1 to 53 corresponding to the extracellular domain of human and rhesus BCMA, respectively, 5 followed in frame by the coding sequence of an artificial Serl-Gly4-Serl-linker, followed in frame by the coding sequence of murine serum albumin, followed in frame by the coding sequence of a Flag tag, followed in frame by the coding sequence of a modified histidine tag (SGHHGGHHGGHH) and a stop codon. For the soluble extracellular domain constructs, the modified cDNA fragments were designed as 10 to contain first a Kozak site for eukaryotic expression of the constructs followed by the coding sequence of the human and macaque BCMA proteins respectively, comprising amino acids 1 to 54 and 1 to 53 corresponding to the extracellular domain of human and rhesus BCMA, respectively, followed in frame by the coding sequence of an artificial Ser1-Glyl-linker, followed in frame by the coding sequence of a Flag tag, followed in frame by the coding sequence of a 15 modified histidine tag (SGHHGGHHGGHH) and a stop codon. The cDNA fragments were also designed to introduce restriction sites at the beginning and at the end of the fragments. The introduced restriction sites, EcoRI at the 5' end and Sall at the 3' end, were utilized in the following cloning procedures. The cDNA fragments were cloned via EcoRI and Sall into a plasmid designated pEF-DHFR (pEF-DHFR is described in Raum et al. 20 Cancer Immunol Immunother 50 (2001) 141-150). The aforementioned procedures were all carried out according to standard protocols (Sambrook, Molecular Cloning; A Laboratory Manual, 3rd edition, Cold Spring Harbour Laboratory Press, Cold Spring Harbour, New York (2001)). 25 B) The coding sequences of human and macaque BCMA as described above and coding sequences of human albumin, human Fcyl, murine Fcyl, murine Fcy2a, murine albumin, rat albumin, rat Fcyl and rat Fcy2b were used for the construction of artificial cDNA sequences encoding soluble fusion proteins of human and macaque BCMA respectively and human albumin, human IgG1 Fc, murine IgG1 Fc, murine IgG2a Fc, murine albumin, rat IgG1 Fc, rat 30 IgG2b and rat albumin respectively as well as soluble proteins comprising only the extracellular domains of BCMA. To generate the constructs for expression of the soluble human and macaque BCMA proteins cDNA fragments were obtained by PCR mutagenesis of the full-length BCMA cDNAs described above and molecular cloning according to standard protocols. For the fusions with albumins the modified cDNA fragments were designed as to contain first a 35 Kozak site for eukaryotic expression of the constructs and the coding sequence of a 19 amino acid immunoglobulin leader peptide, followed in frame by the coding sequence of the 70 extracellular domain of the respective BCMA protein followed in frame by the coding sequence of an artificial Serl-Gly4-Serl-linker, followed in frame by the coding sequence of the respective serum albumin, followed in frame by the coding sequence of a Flag tag, followed in frame by the coding sequence of a modified histidine tag (SGHHGGHHGGHH) and a stop codon. 5 For the fusions with IgG Fcs the modified cDNA fragments were designed as to contain first a Kozak site for eukaryotic expression of the constructs and the coding sequence of a 19 amino acid immunoglobulin leader peptide, followed in frame by the coding sequence of the extracellular domain of the respective BCMA protein followed in frame by the coding sequence of an artificial Serl-Gly4-Serl-linker, except for human IgG1 Fc where an artificial Ser1-Glyl 10 linker was used, followed in frame by the coding sequence of the hinge and Fc gamma portion of the respective IgG, followed in frame by the coding sequence of a Flag tag, followed in frame by the coding sequence of a modified histidine tag (SGHHGGHHGGHH) and a stop codon. For the soluble extracellular domain constructs the modified cDNA fragments were designed as to contain first a Kozak site for eukaryotic expression of the constructs and the coding sequence 15 of a 19 amino acid immunoglobulin leader peptide, followed in frame by the coding sequence of the extracellular domain of the respective BCMA protein followed in frame by the coding sequence of an artificial Ser1-Glyl-linker, followed in frame by the coding sequence of a Flag tag, followed in frame by the coding sequence of a modified histidine tag (SGHHGGHHGGHH) and a stop codon. 20 For cloning of the constructs suitable restriction sites were introduced. The cDNA fragments were all cloned into a plasmid designated pEF-DHFR (pEF-DHFR is described in Raum et al. 2001). The aforementioned procedures were all carried out according to standard protocols (Sambrook, 2001). The following constructs were designed to enable directed panning on distinct epitopes. The 25 coding sequence of murine-human BCMA chimeras and murine-macaque BCMA chimeras (mouse, human and macaque BCMA sequences as described above) and coding sequences of murine albumin and murine Fcyl were used for the construction of artificial cDNA sequences encoding soluble fusion proteins of murine-human and murine-macaque BCMA chimeras respectively and murine IgG1 Fc and murine albumin, respectively. To generate the constructs 30 for expression of the soluble murine-human and murine-macaque BCMA chimeras cDNA fragments of murine BCMA (amino acid 1-49) with the respective epitope domains mutated to the human and macaque sequence respectively were obtained by gene synthesis according to standard protocols. Cloning of constructs was carried out as described above and according to standard protocols (Sambrook, 2001). 35 The following molecules were constructed: 71 * amino acid 1-4 human, murine IgG1 Fc * amino acid 1-4 human, murine albumin * amino acid 1-4 rhesus, murine IgG1 Fc * amino acid 1-4 rhesus, murine albumin 5 0 amino acid 5-18 human, murine IgG1 Fc * amino acid 5-18 human, murine albumin * amino acid 5-18 rhesus, murine IgG1 Fc * amino acid 5-18 rhesus, murine albumin * amino acid 37-49 human, murine IgG1 Fc 10 * amino acid 37-49 human, murine albumin * amino acid 37-49 rhesus, murine IgG1 Fc * amino acid 37-49 rhesus, murine albumin 15 Example 5 5.1 Biacore-based determination of bispecific antibody affinity to human and macaque BCMA and CD3 Biacore analysis experiments were performed using recombinant BCMA fusion proteins with human serum albumin (ALB) to determine BCMA target binding. For CD3 affinity 20 measurements, recombinant fusion proteins having the N-terminal 27 amino acids of the CD3 epsilon (CD3e) fused to human antibody Fc portion were used. This recombinant protein exists in a human CD3e1-27 version and in a cynomolgous CD3e version, both bearing the epitope of the CD3 binder in the bispecific antibodies. In detail, CM5 Sensor Chips (GE Healthcare) were immobilized with approximately 100 to 25 150 RU of the respective recombinant antigen using acetate buffer pH4.5 according to the manufacturer's manual. The bispecific antibody samples were loaded in five concentrations: 50 nM, 25 nM, 12.5 nM, 6.25 nM and 3.13 nM diluted in HBS-EP running buffer (GE Healthcare). Flow rate was 30 to 35 pl/min for 3 min, then HBS-EP running buffer was applied for 8 min again at a flow rate of 30 to 35 pl/ml. Regeneration of the chip was performed using 30 10 mM glycine 0.5 M NaCl pH 2.45. Data sets were analyzed using BiaEval Software (see Figure 4). In general two independent experiments were performed. 5.2 Binding affinity to human and macaque BCMA 72 Binding affinities of BCMAICD3 bispecific antibodies to human and macaque BCMA were determined by Biacore analysis using recombinant BCMA fusion proteins with mouse albumin (ALB). 5 In detail, CM5 Sensor Chips (GE Healthcare) were immobilized with approximately 150 to 200 RU of the respective recombinant antigen using acetate buffer pH4.5 according to the manufacturer's manual. The bispecific antibody samples were loaded in five concentrations: 50 nM, 25 nM, 12.5 nM, 6.25 nM and 3.13 nM diluted in HBS-EP running buffer (GE Healthcare). For BCMA affinity determinations the flow rate was 35 pl/min for 3 min, then HBS-EP running 10 buffer was applied for 10, 30 or 60 min again at a flow rate of 35 pl/ml. Regeneration of the chip was performed using a buffer consisting of a 1:1 mixture of 10 mM glycine 0.5 M NaCl pH 1.5 and 6 M guanidine chloride solution. Data sets were analyzed using BiaEval Software (see Figure 6). In general two independent experiments were performed. 15 Confirmative human and macaque CD3 epsilon binding was performed in single experiments using the same concentrations as applied for BCMA binding; off-rate determination was done for 10 min dissociation time. All BCMA/CD3 bispecific antibodies of epitope cluster E3 showed high affinities to human 20 BCMA in the sub-nanomolar range down to 1-digit picomolar range. Binding to macaque BCMA was balanced, also showing affinities in the 1-digit nanomolar down to subnanomolar range. Affinities and affinity gaps of BCMA/CD3 bispecific antibodies are shown in Table 2. Table 2: Affinities of BCMA/CD3 bispecific antibodies of the epitope cluster E3 to human and 25 macaque BCMA as determined by Biacore analysis, and calculated affinity gaps (ma BCMA : hu BCMA). BCMA/CD3 bispecific hu BCMA ma BCMA Affinity gap antibody [nM] [nM] ma BCMA :hu BCMA BCMA-83 0.031 0.077 2.5 BCMA-98 0.025 0.087 3.5 BCMA-71 0.60 2.2 3.7 BCMA-34 0.051 0.047 1: 1.1 BCMA-74 0.088 0.12 1.4 73 BCMA-20 0.0085 0.016 1.9 5.3 Biacore-based determination of the bispecific antibody affinity to human and macaque BCMA 5 The affinities of BCMA/CD3 bispecific antibodies to recombinant soluble BCMA on CM5 chips in Biacore measurements were repeated to reconfirm KDs and especially off-rates using longer dissociation periods (60 min instead of 10 min as used in the previous experiment). All of the tested BCMA/CD3 bispecific antibodies underwent two independent affinity measurements with five different concentrations each. 10 The affinities of the BCMA/CD3 bispecific antibodies of the epitope cluster E3 were clearly subnanomolar down to 1-digit picomolar, see examples in Table 3. Table 3: Affinities (KD) of BCMA/CD3 bispecific antibodies of the epitope cluster E3 from 15 Biacore experiments using extended dissociation times (two independent experiments each). BCMA/CD3 bispecific antibody KD [nM] human BCMA KD [nM] macaque BCMA BCMA-83 0.053 ± 0.017 0.062 ± 0.011 BCMA-98 0.025 ± 0.003 0.060 ± 0.001 BCMA-71 0.242 ± 0.007 0.720 ± 0.028 BCMA-34 0.089 ± 0.019 0.056 ± 0.003 BCMA-74 0.076 ±0.002 0.134 ±0.010 BCMA-20 0.0095 ± 0.0050 0.0060 ± 0.0038 Exam ple 6 20 Bispecific binding and interspecies cross-reactivity For confirmation of binding to human and macaque BCMA and CD3, bispecific antibodies were tested by flow cytometry using CHO cells transfected with human and macaque BCMA, respectively, the human multiple myeloma cell line NCI-H929 expressing native human BCMA, 74 CD3-expressing human T cell leukemia cell line HPB-ALL (DSMZ, Braunschweig, ACC483) and the CD3-expressing macaque T cell line 4119LnPx (Knappe A, et al., Blood, 2000, 95, 3256 3261). Moreover, untransfected CHO cells were used as negative control. 5 For flow cytometry 200,000 cells of the respective cell lines were incubated for 30 min on ice with 50 pl of purified bispecific antibody at a concentration of 5 pg/ml. The cells were washed twice in PBS/2% FCS and binding of the constructs was detected with a murine PentaHis antibody (Qiagen; diluted 1:20 in 50 pl PBS/2% FCS). After washing, bound PentaHis antibodies were detected with an Fc gamma-specific antibody (Dianova) conjugated to 10 phycoerythrin, diluted 1:100 in PBS/2% FCS. Samples were measured by flow cytometry on a FACSCanto I instrument and analyzed by FACSDiva software (both from Becton Dickinson). The BCMA/CD3 bispecific antibodies of epitope cluster E3 stained CHO cells transfected with human and macaque BCMA, the human BCMA-expressing multiple myeloma cell line NCI 15 H929 as well as human and macaque T cells. Moreover, there was no staining of untransfected CHO cells (see Figure 7). Example 7 Scatchard-based determination of bispecific-antibody affinity to human and macaque 20 BCMA For Scatchard analysis, saturation binding experiments are performed using a monovalent detection system developed at Micromet (anti-His Fab/Alexa 488) to precisely determine monovalent binding of the bispecific antibodies to the respective cell line. 2 x 104 cells of the respective cell line (recombinantly human BCMA-expressing CHO cell line, 25 recombinantly macaque BCMA-expressing CHO cell line) are incubated with each 50 pl of a triplet dilution series (eight dilutions at 1:2) of the respective BCMA bispecific antibody starting at 100 nM followed by 16 h incubation at 4*C under agitation and one residual washing step. Then, the cells are incubated for further 30 min with 30 pl of an anti-His Fab/Alexa488 solution (Micromet; 30 pg/ml). After one washing step, the cells are resuspended in 150 pl FACS buffer 30 containing 3.5 % formaldehyde, incubated for further 15 min, centrifuged, resuspended in FACS buffer and analyzed using a FACS Cantoll machine and FACS Diva software. Data are generated from two independent sets of experiments. Values are plotted as hyperbole binding curves. Respective Scatchard analysis is calculated to extrapolate maximal binding (Bmax). The concentrations of bispecific antibodies at half-maximal binding are determined reflecting the 75 respective KDs. Values of triplicate measurements are plotted as hyperbolic curves. Maximal binding is determined using Scatchard evaluation and the respective KDs are calculated. The affinities of BCMA/CD3 bispecific antibodies to CHO cells transfected with human or 5 macaque BCMA were determined by Scatchard analysis as the most reliable method for measuring potential affinity gaps between human and macaque BCMA. Cells expressing the BCMA antigen were incubated with increasing concentrations of the respective monomeric BCMA/CD3 bispecific antibody until saturation was reached (16 h). 10 Bound bispecific antibody was detected by flow cytometry. The concentrations of BCMA/CD3 bispecific antibodies at half-maximal binding were determined reflecting the respective KDs. Values of triplicate measurements were plotted as hyperbolic curves and as S-shaped curves to demonstrate proper concentration ranges from minimal to optimal binding. Maximal binding 15 (Bmax) was determined (Figure 8) using Scatchard evaluation and the respective KDs were calculated. Values depicted in Table 4 were derived from two independent experiments per BCMA/CD3 bispecific antibody. Cell based Scatchard analysis confirmed that the BCMA/CD3 bispecific antibodies of the 20 epitope cluster E3 are subnanomolar in affinity to human BCMA and present with a small interspecies BCMA affinity gap of below five. Table 4: Affinities (KD) of BCMA/CD3 bispecific antibodies of the epitope cluster E3 from cell based Scatchard analysis (two independent experiments each) with the calculated affinity gap 25 KD macaque BCMA / KD human BCMA. BCMAICD3 KD [nM] KD [nM] x-fold KD difference bispecific antibody human BCMA macaque BCMA KD ma vs. KD hu BCMA BCMA-83 0.40 ± 0.13 1.22 ± 0.25 3.1 BCMA-98 0.74 ± 0.02 1.15 ±0.64 1.6 BCMA-71 0.78 ± 0.07 3.12 ± 0.26 4.0 BCMA-34 0.77 ± 0.11 0.97 ± 0.33 1.3 BCMA-74 0.67 ± 0.03 0.95 ± 0.06 1.4 BCMA-20 0.78 ±0.10 0.85 ± 0.01 1.1 76 Example 8 Cytotoxic activity 8.1 Chromium release assay with stimulated human T cells 5 Stimulated T cells enriched for CD8' T cells were obtained as described below. A petri dish (145 mm diameter, Greiner bio-one GmbH, Kremsmunster) was coated with a commercially available anti-CD3 specific antibody (OKT3, Orthoclone) in a final concentration of 1 pg/ml for 1 hour at 37*C. Unbound protein was removed by one washing step with PBS. 3 - 5 x 107 human PBMC were added to the precoated petri dish in 120 ml of RPMI 1640 with 10 stabilized glutamine / 10% FCS / IL-2 20 U/ml (Proleukin@, Chiron) and stimulated for 2 days. On the third day, the cells were collected and washed once with RPMI 1640. IL-2 was added to a final concentration of 20 U/ml and the cells were cultured again for one day in the same cell culture medium as above. CD8 4 cytotoxic T lymphocytes (CTLs) were enriched by depletion of CD4' T cells and 15 CD56* NK cells using Dynal-Beads according to the manufacturer's protocol. Macaque or human BCMA-transfected CHO target cells were washed twice with PBS and labeled with 11.1 MBq "Cr in a final volume of 100 pl RPMI with 50% FCS for 60 minutes at 37*C. Subsequently, the labeled target cells were washed 3 times with 5 ml RPMI and then used in the cytotoxicity assay. The assay was performed in a 96-well plate in a total volume of 20 200 pi supplemented RPMI with an E:T ratio of 10:1. A starting concentration of 0.01 - 1 pg/mI of purified bispecific antibody and threefold dilutions thereof were used. Incubation time for the assay was 18 hours. Cytotoxicity was determined as relative values of released chromium in the supernatant relative to the difference of maximum lysis (addition of Triton-X) and spontaneous lysis (without effector cells). All measurements were carried out in quadruplicates. Measurement 25 of chromium activity in the supernatants was performed in a Wizard 3" gamma counter (Perkin Elmer Life Sciences GmbH, Koln, Germany). Analysis of the results was carried out with Prism 5 for Windows (version 5.0, GraphPad Software Inc., San Diego, California, USA). EC50 values calculated by the analysis program from the sigmoidal dose response curves were used for comparison of cytotoxic activity (see Figure 5). 30 8.2 Potency of redirecting stimulated human effector T cells against human BCMA transfected CHO cells The cytotoxic activity of BCMA/CD3 bispecific antibodies was analyzed in a 51-chromium ( 51 Cr) 35 release cytotoxicity assay using CHO cells transfected with human BCMA as target cells, and 77 stimulated enriched human CD8 T cells as effector cells. The experiment was carried out as described in Example 8.1. All BCMA/CD3 bispecific antibodies of epitope cluster E3 showed very potent cytotoxic activity 5 against human BCMA transfected CHO cells with EC50-values in the 1-digit pg/mi range or even below (Figure 9 and Table 5). So the epitope cluster E3 presents with a very favorable epitope-activity relationship supporting very potent bispecific antibody mediated cytotoxic activity. 10 Table 5: EC50 values [pg/ml] of BCMA/CD3 bispecific antibodies of the epitope cluster E3 analyzed in a 51-chromium ( 5 'Cr) release cytotoxicity assay using CHO cells transfected with human BCMA as target cells, and stimulated enriched human CD8 T cells as effector cells. BCMAICD3 bispecific antibody EC50 [pg/ml] R square value BCMA-83 0.38 0.79 BCMA-98 0.27 0,85 BCMA-71 3.2 0.85 BCMA-34 3.4 0.81 BCMA-74 0.73 0.80 BCMA-20 0.83 0.82 15 8.3 FACS-based cytotoxicity assay with unstimulated human PBMC Isolation of effector cells Human peripheral blood mononuclear cells (PBMC) were prepared by Ficoll density gradient centrifugation from enriched lymphocyte preparations (buffy coats), a side product of blood 20 banks collecting blood for transfusions. Buffy coats were supplied by a local blood bank and PBMC were prepared on the same day of blood collection. After Ficoll density centrifugation and extensive washes with Dulbecco's PBS (Gibco), remaining erythrocytes were removed from PBMC via incubation with erythrocyte lysis buffer (155 mM NH 4 CI, 10 mM KHCO 3 , 100 pM EDTA). Platelets were removed via the supernatant upon centrifugation of PBMC at 100 x g. 25 Remaining lymphocytes mainly encompass B and T lymphocytes, NK cells and monocytes. PBMC were kept in culture at 37*C/5% CO2 in RPMI medium (Gibco) with 10% FCS (Gibco). Depletion of CD14* and CD56* cells 78 For depletion of CD14* cells, human CD14 MicroBeads (Milteny Biotec, MACS, #130-050-201) were used, for depletion of NK cells human CD56 MicroBeads (MACS, #130-050-401). PBMC were counted and centrifuged for 10 min at room temperature with 300 x g. The supernatant was discarded and the cell pellet resuspended in MACS isolation buffer [80 pU 107 cells; PBS 5 (Invitrogen, #20012-043), 0.5% (v/v) FBS (Gibco, #10270-106), 2 mM EDTA (Sigma-Aldrich, #E-6511)]. CD14 MicroBeads and CD56 MicroBeads (20 pL/10 7 cells) were added and incubated for 15 min at 4 - 8 0 C. The cells were washed with MACS isolation buffer (1 - 2 mL/10 7 cells). After centrifugation (see above), supernatant was discarded and cells resuspended in MACS isolation buffer (500 pL/10 cells). CD14/CD56 negative cells were then isolated using 10 LS Columns (Miltenyi Biotec, #130-042-401). PBMC w/o CD14+/CD56+ cells were cultured in RPMI complete medium i.e. RPM11640 (Biochrom AG, #FG1215) supplemented with 10% FBS (Biochrom AG, #S0115), 1x non-essential amino acids (Biochrom AG, #K0293), 10 mM Hepes buffer (Biochrom AG, #L1613), 1 mM sodium pyruvate (Biochrom AG, #L0473) and 100 U/mL penicillin/streptomycin (Biochrom AG, #A2213) at 37 0 C in an incubator until needed. 15 Target cell labeling For the analysis of cell lysis in flow cytometry assays, the fluorescent membrane dye DiOC 1 8 (DiO) (Molecular Probes, #V22886) was used to label human BCMA- or macaque BCMA transfected CHO cells as target cells and distinguish them from effector cells. Briefly, cells were harvested, washed once with PBS and adjusted to 106 cell/mL in PBS containing 2 % (v/v) FBS 20 and the membrane dye DiO (5 pL/10 6 cells). After incubation for 3 min at 37 0 C, cells were washed twice in complete RPMI medium and the cell number adjusted to 1.25 x 10 5 cells/mL. The vitality of cells was determined using 0.5 % (vlv) isotonic EosinG solution (Roth, #45380). Flow cytometry based analysis This assay was designed to quantify the lysis of macaque or human BCMA-transfected CHO 25 cells in the presence of serial dilutions of BCMA bispecific antibodies. Equal volumes of DiO-labeled target cells and effector cells (i.e., PBMC w/o CD14* cells) were mixed, resulting in an E.T cell ratio of 10:1. 160 pL of this suspension were transferred to each well of a 96-well plate. 40 pL of serial dilutions of the BCMA bispecific antibodies and a negative control bispecific (an CD3-based bispecific antibody recognizing an irrelevant target antigen) or 30 RPMI complete medium as an additional negative control were added. The bispecific antibody mediated cytotoxic reaction proceeded for 48 hours in a 7% CO 2 humidified incubator. Then cells were transferred to a new 96-well plate and loss of target cell membrane integrity was monitored by adding propidium iodide (PI) at a final concentration of 1 pg/mL. PI is a membrane impermeable dye that normally is excluded from viable cells, whereas dead cells take it up and 35 become identifiable by fluorescent emission. 79 Samples were measured by flow cytometry on a FACSCanto 11 instrument and analyzed by FACSDiva software (both from Becton Dickinson). Target cells were identified as DiO-positive cells. PI-negative target cells were classified as living target cells. Percentage of cytotoxicity was calculated according to the following formula: 5 Cytotoxicity [%] n target cells x 100 n tai get cells n = number of events Using GraphPad Prism 5 software (Graph Pad Software, San Diego), the percentage of cytotoxicity was plotted against the corresponding bispecific antibody concentrations. Dose 10 response curves were analyzed with the four parametric logistic regression models for evaluation of sigmoid dose response curves with fixed hill slope and EC50 values were calculated. 8.4 Unstimulated human PBMC against human BCMA-transfected target cells 15 The cytotoxic activity of BCMA/CD3 bispecific antibodies was analyzed in a FACS-based cytotoxicity assay using CHO cells transfected with human BCMA as target cells, and unstimulated human PBMC as effector cells. The assay was carried out as described above (Example 8.3). 20 The results of the FACS-based cytotoxicity assays with unstimulated human PBMC as effector cells and human BCMA-transfected CHO cells as targets are shown in Figure 10 and Table 6. Table 6: EC50 values [pg/ml] of BCMA/CD3 bispecific antibodies of epitope cluster E3 as 25 measured in a 48-hour FACS-based cytotoxicity assay with unstimulated human PBMC as effector cells and CHO cells transfected with human BCMA as target cells. BCMA/CD3 bispecific antibody EC50 [pg/mi] R square value BCMA-83 212 0.97 BCMA-7 102 0.97 BCMA-5 58.4 0.94 BCMA-98 53.4 0.95 BCMA-71 208 0.94 80 BCMA-34 149 0.94 BCMA-74 125 0.97 BCMA-20 176 0.98 Example 9 9.1 Exclusion of cross-reactivity with BAFF-receptor 5 For flow cytometry, 200,000 cells of the respective cell lines were incubated for 30 min on ice with 50 pl of purified bispecific molecules at a concentration of 5 pg/ml. The cells were washed twice in PBS with 2% FCS and binding of the constructs was detected with a murine PentaHis antibody (Qiagen; diluted 1:20 in 50 pl PBS with 2% FCS). After washing, bound PentaHis antibodies were detected with an Fc gamma-specific antibody (Dianova) conjugated to 10 phycoerythrin, diluted 1:100 in PBS with 2% FCS. Samples were measured by flow cytometry on a FACSCanto II instrument and analyzed by FACSDiva software (both from Becton Dickinson). The bispecific binders were shown to not be cross-reactive with BAFF receptor. 9.2 Exclusion of BCMA/CD3 bispecific antibody cross-reactivity with human BAFF 15 receptor (BAFF-R) and TACI For exclusion of binding to human BAFF-R and TACI, BCMA/CD3 bispecific antibodies were tested by flow cytometry using CHO cells transfected with human BAFF-R and TACI, respectively. Moreover, L363 multiple myeloma cells were used as positive control for binding to 20 human BCMA. Expression of BAFF-R and TACI antigen on CHO cells was confirmed by two positive control antibodies. Flow cytometry was performed as described in the previous example. Flow cytometric analysis confirmed that none of the BCMA/CD3 bispecific antibodies of the 25 epitope cluster E3 cross-reacts with human BAFF-R or human TACI (see Figure 11). Example 10 Cytotoxic activity The potency of human-like BCMA bispecific antibodies in redirecting effector T cells against 30 BCMA-expressing target cells is analyzed in five additional in vitro cytotoxicity assays: 81 1. The potency of BCMA bispecific antibodies in redirecting stimulated human effector T cells against a BCMA-positive (human) tumor cell line is measured in a 51-chromium release assay. 2. The potency of BCMA bispecific antibodies in redirecting the T cells in unstimulated 5 human PBMC against human BCMA-transfected CHO cells is measured in a FACS-based cytotoxicity assay. 3. The potency of BCMA bispecific antibodies in redirecting the T cells in unstimulated human PBMC against a BCMA-positive (human) tumor cell line is measured in a FACS-based cytotoxicity assay. 10 4. For confirmation that the cross-reactive BCMA bispecific antibodies are capable of redirecting macaque T cells against macaque BCMA-transfected CHO cells, a FACS-based cytotoxicity assay is performed with a macaque T cell line as effector T cells. 5. The potency gap between monomeric and dimeric forms of BCMA bispecific antibodies is determined in a 51-chromium release assay using human BCMA-transfected CHO cells as 15 target cells and stimulated human T cells as effector cells. Example 11 Stimulated human T cells against the BCMA-positive human multiple myeloma cell line L363 20 The cytotoxic activity of BCMA/CD3 bispecific antibodies was analyzed in a 51-chromium ("Cr) release cytotoxicity assay using the BCMA-positive human multiple myeloma cell line L363 (DSMZ No. ACC49) as source of target cells, and stimulated enriched human CD8 T cells as effector cells. The assay was carried out as described in Example 8.1. 25 In accordance with the results of the 51-chromium release assays with stimulated enriched human CD8 T lymphocytes as effector cells and human BCMA-transfected CHO cells as targets, BCMA/CD3 bispecific antibodies of epitope cluster E3 are very potent in cytotoxic activity (Figure 12 and Table 7). 30 Another group of antibodies was identified during epitope clustering (see Examples 1 and 3), which is capable of binding to epitope clusters 1 and 4 of BCMA ("E1/E4"). Unexpectedly, BCMA/CD3 bispecific antibodies of epitope cluster E1/E4 - although potent in cytotoxic activity against CHO cell transfected with human BCMA - proved to be rather weakly cytotoxic against 35 the human multiple myeloma cell line L363 expressing native BCMA at low density on the cell 82 surface (Figure 12 and Table 7). Without wishing to be bound by theory, the inventors believe that the E1/E4 epitope of human BCMA might be less well accessible on natural BCMA expressers than on BCMA-transfected cells. 5 Table 7: EC50 values [pg/ml] of BCMA/CD3 bispecific antibodies of epitope clusters E1/E4 (rows 1 and 2) and E3 (rows 3 to 8) analyzed in an 18-hour 51-chromium ( 51 Cr) release cytotoxicity assay with the BCMA-positive human multiple myeloma cell line L363 as source of target cells, and stimulated enriched human CD8 T cells as effector cells. BCMA/CD3 bispecific antibody EC50 [pg/ml] R square value 1 BCMA-54 685 0.84 2 BCMA-53 1107 0.82 3 BCMA-83 28 0.83 4 BCMA-98 10 0.81 5 BCMA-71 125 0.86 6 BCMA-34 42 0.81 7 BCMA-74 73 0.79 8 BCMA-20 21 0.85 10 Example 12 Unstimulated human PBMC against the BCMA-positive human multiple myeloma cell line L363 15 The cytotoxic activity of BCMA/CD3 bispecific antibodies was furthermore analyzed in a FACS based cytotoxicity assay using the BCMA-positive human multiple myeloma cell line L363 (DSMZ, ACC49) - showing the weakest surface expression of native BCMA of all tested target T cell lines - as source of target cells and unstimulated human PBMC as effector cells. The 20 assay was carried out as described above (Example 8.3). As observed in the 51-chromium release assay with stimulated enriched human CD8 T lymphocytes against the human multiple myeloma cell line L363, the BCMA/CD3 bispecific antibodies of epitope cluster E1/E4 - in contrast to their potent cytotoxic activity against CHO 25 cell transfected with human BCMA - proved to be again less potent in redirecting the cytotoxic activity of unstimulated PBMC against the human multiple myeloma cell line L363 expressing 83 native BCMA at low density on the cell surface. This is in line with the theory provided hereinabove, i.e., the E1/E4 epitope of human BCMA may be less well accessible on natural BCMA expressers than on BCMA-transfected cells. BCMA/CD3 bispecific antibodies of the epitope cluster E3 presented with 3-digit pg/ml EC50-values in this assay (see Figure 13 and 5 Table 8). Table 8: EC50 values [pg/ml] of BCMA/CD3 bispecific antibodies of epitope clusters E1/E4 (rows 1 and 2) and E3 (rows 3 to 8) as measured in a 48-hour FACS-based cytotoxicity assay with unstimulated human PBMC as effector cells and the human multiple myeloma cell line 10 L363 as source of target cells. BCMAICD3 bispecific antibody EC50 [pg/ml] R square value 1 BCMA-54 3162 0.99 2 BCMA-53 2284 0.98 3 BCMA-83 241 0.99 4 BCMA-98 311 0.99 5 BCMA-71 284 0.99 6 BCMA-34 194 0.99 7 BCMA-74 185 0.99 8 BCMA-20 191 0.99 Expectedly, EC50-values were higher in cytotoxicity assays with unstimulated PBMC as effector 15 cells than in cytotoxicity assays using enriched stimulated human CD8 T cells. Example 13 Unstimulated human PBMC against the BCMA-positive human multiple myeloma cell line NCI-H929 20 The cytotoxic activity of BCMA/CD3 bispecific antibodies was analyzed in a FACS-based cytotoxicity assay using the BCMA-positive human multiple myeloma cell line NCI-H929 (ATCC CRL-9068) as source of target cells and unstimulated human PBMC as effector cells. The assay was carried out as described above (Example 8.3). 25 84 The results of this assay with another human multiple myeloma cell line (i.e. NCI-H929) expressing native BCMA on the cell surface confirm those obtained with human multiple myeloma cell line L363. Again, BCMA/CD3 bispecific antibodies of epitope cluster E1/E4 - in contrast to their potent cytotoxic activity against CHO cell transfected with human BCMA 5 proved to be less potent in redirecting the cytotoxic activity of unstimulated PBMC against human multiple myeloma cells confirming the theory that the E1/E4 epitope of human BCMA may be less well accessible on natural BCMA expressers than on BCMA-transfected cells. Such an activity gap between BCMA-transfected target cells and natural expressers as seen for the E1/E4 binders was not found for the E3. BCMA/CD3 bispecific antibodies of the epitope 10 cluster E3 presented with 2- to 3-digit pg/ml EC50-values and hence redirected unstimulated PBMC against NCI-H929 target cells with very good EC50-values (see Figure 14 and Table 9). Table 9: EC50 values [pg/ml] of BCMA/CD3 bispecific antibodies of epitope clusters E1/E4 (rows 1 and 2) and E3 (rows 3 to 8) as measured in a 48-hour FACS-based cytotoxicity assay 15 with unstimulated human PBMC as effector cells and the human multiple myeloma cell line NCI H929 as source of target cells. BCMA/CD3 bispecific antibody EC50 [pg/ml] R square value 1 BCMA-54 2604 0.99 2 BCMA-53 2474 0.99 3 BCMA-83 154 0.93 4 BCMA-98 67.6 0.87 5 BCMA-71 50.7 0.96 6 BCMA-34 227 0.99 7 BCMA-74 103 0.97 8 BCMA-20 123 0.97 As expected, EC50-values were lower with the human multiple myeloma cell line NCI-H929, 20 which expresses higher levels of BCMA on the cell surface compared to L363. Example 14 Macaque T cells against macaque BCMA-expressing target cells 25 85 Finally, the cytotoxic activity of BCMA/CD3 bispecific antibodies was analyzed in a FACS-based cytotoxicity assay using CHO cells transfected with macaque BCMA as target cells, and a macaque T cell line as source of effector cells. 5 The macaque T cell line 4119LnPx (Knappe et al. Blood 95:3256-61 (2000)) was used as source of effector cells. Target cell labeling of macaque BCMA-transfected CHO cells and flow cytometry based analysis of cytotoxic activity was performed as described above. Macaque T cells from cell line 4119LnPx were induced to efficiently kill macaque BCMA 10 transfected CHO cells by BCMA/CD3 bispecific antibodies of the E3 epitope cluster. The antibodies presented very potently with 1-digit to low 2-digit pg/ml EC50-values in this assay, confirming that these antibodies are very active in the macaque system. On the other hand, BCMA/CD3 bispecific antibodies of the epitope cluster E1/E4 showed a significantly weaker potency with EC50-values in the 2-digit to 3-digit pg/ml range (see Figure 15 and Table 10). The 15 E3 specific antibodies are hence about 3 to almost 100 times more potent in the macaque system. Table 10: EC50 values [pg/ml] of BCMA/CD3 bispecific antibodies of epitope clusters E1/E4 (rows 1 and 2) and E3 (rows 3 to 8) as measured in a 48-hour FACS-based cytotoxicity assay 20 with macaque T cell line 4119LnPx as effector cells and CHO cells transfected with macaque BCMA as target cells. BCMA/CD3 bispecific antibody EC50 [pg/ml] R square value 1 BCMA-54 78.5 0.98 2 BCMA-53 183 0.96 3 BCMA-83 10.9 0.97 4 BCMA-98 2.5 0.89 5 BCMA-71 3.2 0.97 6 BCMA-34 2.1 0.95 7 BCMA-74 2.0 0.95 8 BCMA-20 26 0.98 25 Example 15 Potency gap between BCMA/CD3 bispecific antibody monomer and dimer 86 In order to determine the difference in cytotoxic activity between the monomeric and the dimeric isoform of individual BCMA/CD3 bispecific antibodies (referred to as potency gap), a 51 chromium release cytotoxicity assay as described hereinabove (Example 8.1) was carried out 5 with purified BCMA/CD3 bispecific antibody monomer and dimer. The potency gap was calculated as ratio between EC50 values of the bispecific antibody's monomer and dimer. Potency gaps of the tested BCMA/CD3 bispecific antibodies of the epitope cluster E3 were between 0.03 and 1.2. There is hence no substantially more active dimer compared to its respective monomer. 10 Example 16 Monomer to dimer conversion after three freeze/thaw cycles Bispecific BCMA/CD3 antibody monomer were subjected to three freeze/thaw cycles followed 15 by high performance SEC to determine the percentage of initially monomeric antibody, which had been converted into antibody dimer. 15 pg of monomeric antibody were adjusted to a concentration of 250 pg/mI with generic buffer and then frozen at -80 0 C for 30 min followed by thawing for 30 min at room temperature. After 20 three freeze/thaw cycles the dimer content was determined by HP-SEC. To this end, 15 pg aliquots of the monomeric isoforms of the antibodies were thawed and equalized to a concentration of 250 pg/ml in the original SEC buffer (10 mM citric acid - 75 mM lysine HCI 4% trehalose - pH 7.2) followed by incubation at 37 0 C for 7 days. A high resolution SEC Column TSK Gel G3000 SWXL (Tosoh, Tokyo-Japan) was connected to an Akta Purifier 10 FPLC (GE 25 Lifesciences) equipped with an A905 Autosampler. Column equilibration and running buffer consisted of 100 mM KH2PO4 - 200 mM Na2SO4 adjusted to pH 6.6. After 7 days of incubation, the antibody solution (15 pg protein) was applied to the equilibrated column and elution was carried out at a flow rate of 0.75 ml/min at a maximum pressure of 7 MPa. The whole run was monitored at 280, 254 and 210 nm optical absorbance. Analysis was done by 30 peak integration of the 210 nm signal recorded in the Akta Unicorn software run evaluation sheet. Dimer content was calculated by dividing the area of the dimer peak by the total area of monomer plus dimer peak. The BCMA/CD3 bispecific antibodies of the epitope cluster E3 presented with dimer 35 percentages of 0.7 to 1.1% after three freeze/thaw cycles, which is considered good. However, 87 the dimer conversion rates of BCMA/CD3 bispecific antibodies of the epitope cluster E1/E4 reached unfavorably high values, exceeding the threshold to disadvantageous dimer values of 22.5% (4.7% and 3.8%, respectively), see Table 11. 5 Table 11: Percentage of monomeric versus dimeric BCMA/CD3 bispecific antibodies of epitope clusters E1/E4 (rows 1 and 2) and E3 (rows 3 to 8) after three freeze/thaw cycles as determined by High Performance Size Exclusion Chromatography (HP-SEC). BCMAICD3 bispecific antibody Monomer [%] Dimer [%] 1 BCMA-54 95.3 4.7 2 BCMA-53 96.2 3.8 3 BCMA-83 99.1 0.9 4 BCMA-98 99.1 0.9 5 BCMA-71 99.1 0.9 6 BCMA-34 98.9 1.1 7 BCMA-74 99.3 0.7 8 BCMA-20 99.2 0.8 10 Example 17 Thermostability Temperature melting curves were determined by Differential Scanning Calorimetry (DSC) to 15 determine intrinsic biophysical protein stabilities of the BCMA/CD3 bispecific antibodies. These experiments were performed using a MicroCal LLC (Northampton, MA, U.S.A) VP-DSC device. The energy uptake of a sample containing BCMA/CD3 bispecific antibody was recorded from 20 to 90 0 C compared to a sample which just contained the antibody's formulation buffer. 20 In detail, BCMA/CD3 bispecific antibodies were adjusted to a final concentration of 250 pg/mI in storage buffer. 300 pl of the prepared protein solutions were transferred into a deep well plate and placed into the cooled autosampler rack position of the DSC device. Additional wells were filled with the SEC running buffer as reference material for the measurement. For the measurement process the protein solution was transferred by the autosampler into a capillary. 25 An additional capillary was filled with the SEC running buffer as reference. Heating and 88 recording of required heating energy to heat up both capillaries at equal temperature ranging from 20 to 900C was done for all samples. For recording of the respective melting curve, the overall sample temperature was increased 5 stepwise. At each temperature T energy uptake of the sample and the formulation buffer reference was recorded. The difference in energy uptake Cp (kcal/mole/*C) of the sample minus the reference was plotted against the respective temperature. The melting temperature is defined as the temperature at the first maximum of energy uptake. 10 All tested BCMA/CD3 bispecific antibodies of the epitope cluster E3 showed favorable thermostability with melting temperatures above 600C, more precisely between 61.620C and 63.05 0 C. Exam ple 18 15 Exclusion of plasma interference by flow cytometry To determine potential interaction of BCMA/CD3 bispecific antibodies with human plasma proteins, a plasma interference test was established. To this end, 10 pg/ml of the respective BCMA/CD3 bispecific antibodies were incubated for one hour at 370C in 90 % human plasma. 20 Subsequently, the binding to human BCMA expressing CHO cells was determined by flow cytometry. For flow cytometry, 200,000 cells of the respective cell lines were incubated for 30 min on ice with 50 pl of purified antibody at a concentration of 5 pg/ml. The cells were washed twice in 25 PBS/2% FCS and binding of the constructs was detected with a murine PentaHis antibody (Qiagen; diluted 1:20 in 50 pl PBS/2% FCS). After washing, bound PentaHis antibodies were detected with an Fc gamma-specific antibody (Dianova) conjugated to phycoerythrin, diluted 1:100 in PBS/2% FCS. Samples were measured by flow cytometry on a FACSCanto 11 instrument and analyzed by FACSDiva software (both from Becton Dickinson). 30 The obtained data were compared with a control assay using PBS instead of human plasma. Relative binding was calculated as follows: (signal PBS sample / signal w/o detection agent) / (signal plasma sample / signal w/o detection agent). 35 89 In this experiment it became obvious that there was no significant reduction of target binding of the respective BCMA/CD3 bispecific antibodies of the epitope cluster E3 mediated by plasma proteins. The relative plasma interference value was below a value of 2 in all cases, more precisely between 1.29 ± 0.25 and 1.70 ± 0.26 (with a value of "2" being considered as lower 5 threshold for interference signals). Example 19 Therapeutic efficacy of BCMA/CD3 bispecific antibodies in human tumor xenograft models 10 On day 1 of the study, 5x10 6 cells of the human cancer cell line NCI-H929 were subcutaneously injected in the right dorsal flank of female NOD/SCID mice. On day 9, when the mean tumor volume had reached about 100 mm 3 , in vitro expanded human CD3* T cells were transplanted into the mice by injection of about 2x10 7 cells into the peritoneal 15 cavity of the animals. Mice of vehicle control group 1 (n=5) did not receive effector cells and were used as an untransplanted control for comparison with vehicle control group 2 (n=10, receiving effector cells) to monitor the impact of T cells alone on tumor growth. The antibody treatment started on day 13, when the mean tumor volume had reached about 200 mm 3 . The mean tumor size of each treatment group on the day of treatment start was not 20 statistically different from any other group (analysis of variance). Mice were treated with 0.5 mg/kg/day of the BCMA/CD3 bispecific antibodies BCMA-98 x CD3 (group 3, n=7) or BCMA-34 x CD3 (group 4, n=6) by intravenous bolus injection for 17 days. Tumors were measured by caliper during the study and progress evaluated by intergroup comparison of tumor volumes (TV). The tumor growth inhibition T/C [%] was determined by 25 calculating TV as T/C% = 100 x (median TV of analyzed group) / (median TV of control group 2). The results are shown in Table 12 and Figure 16. Table 12: Median tumor volume (TV) and tumor growth inhibition (T/C) at days 13 to 30. Dose Data d13 d14 d15 d16 d18 d19 d21 d23 d26 d28 d30 group 1 Vehi. med.TV control I[mm 238 288 395 425 543 632 863 1067 1116 1396 2023 90 w/o T cells T/C [%] 120 123 127 118 104 114 122 113 87 85 110 2 med.TV Veic ed.TV m 198 235 310 361 525 553 706 942 1290 1636 1839 Vehicle [M control T/C [%] 100 100 100 100 100 100 100 100 100 100 100 med.TV 3CMA- mmV 207 243 248 235 164 137 93.5 46.2 21.2 0.0 0.0 BCMA- [M 98 T/C [%] 105 104 79.7 65.0 31.2 24.7 13.2 4.9 1.6 0.0 0.0 4 med.TV BCMA- mmV 206 233 212 189 154 119 56.5 17.4 0.0 0.0 0.0

BCMA

34 T/C [%] 104 99.2 68.2 52.3 29.4 21.5 8.0 1.8 0.0 0.0 0.0 Example 20 Exclusion of lysis of target negative cells 5 An in vitro lysis assay was carried out using the BCMA-positive human multiple myeloma cell line NCI-H929 and purified T cells at an effector to target cell ratio of 5:1 and with an incubation time of 24 hours. BCMA/CD3 bispecific antibodies of epitope cluster E3 (BCMA-34 and BCMA 98) showed high potency and efficacy in the lysis of NCI-H929. However, no lysis was detected 10 in the BCMA negative cell lines HL60 (AML / myeloblast morphology), MES-SA (uterus sarcoma, fibroblast morphology), and SNU-16 (stomach carcinoma, epithelial morphology) for up to 500 nM of the respective antibody. Example 21 15 Induction of T cell activation of different PBMC subsets A FACS-based cytotoxicity assay (48h; E:T = 10:1) was carried out using human multiple myeloma cell lines NCI-H929, L-363 and OPM-2 as target cells and different subsets of human PBMC (CD4' / CD8' / CD25* / CD69*) as effector cells. The results (see Table 13) show that 20 the degree of activation, as measured by the EC 50 value, is essentially in the same range for the different analyzed PBMC subsets. 91 Table 13: EC50 values [ng/ml] of BCMA/CD3 bispecific antibodies of epitope cluster E3 as measured in a 48-hour FACS-based cytotoxicity assay with different subsets of human PBMC as effector cells and different human multiple myeloma cell lines as target cells. 5

EC

6 o [ng/m Cell line PBMC BCMA-98 x CD3 BCMA-34 x CD3 CD4' i CD25* 1.46 1.20 CD8' / CD25* 0.53 0.49 NCI-H929__________ CD4* / CD69* 0.59 0.47 CD8' / CD69* 0.21 0.21 CD4* / CD25* 2.52 4.88 CD8' / CD25' 1.00 1.20 OPM-2 CD4* / CD69* 1.65 2.27 CD8' / CD69* 0.48 0.42 CD4* / CD25* 0.54 0.62 CD8' / CD25* 0.24 0.28 L-363 CD4' / CD69* 0.35 0.34 CD8' / CD69* 0.12 0.11 Example 22 Induction of cytokine release 10 A FACS-based cytotoxicity assay (48h; E:T = 10:1) was carried out using human multiple myeloma cell lines NCI-H929, L-363 and OPM-2 as target cells and human PBMC as effector cells. The levels of cytokine release [pg/ml] were determined at increasing concentrations of BCMA/CD3 bispecific antibodies of epitope cluster E3. The following cytokines were analyzed: 15 11-2, IL-6, IL-10, TNF and IFN-gamma. The results are shown in Table 14 and Figure 17. 92 Table 14: Release of IL-2, IL-6, IL-10, TNF and IFN-gamma [pg/ml] induced by 2.5 pg/ml of BCMA/CD3 bispecific antibodies of epitope cluster E3 (BCMA-98 and BCMA-34) in a 48-hour FACS-based cytotoxicity assay with human PBMC as effector cells and different human multiple myeloma cell lines as target cells (E:T = 10:1). 5 Cytokine levels [pg/ml] NCI-H929 IL-2 IL-6 IL-10 TNF IFN-gamma BCMA-98 1357 699 2798 10828 73910 BCMA-34 1327 631 3439 6675 77042 OPM-2 IL-2 IL-6 IL-10 TNF IFN-gamma BCMA-98 41 118 990 5793 33302 BCMA-34 28 109 801 4913 23214 L-363 IL-2 IL-6 IL-10 TNF IFN-gamma BCMA-98 97 314 2433 5397 64981 BCMA-34 168 347 2080 5930 75681 93 SEQ ID Designation Designation Formiat/ Ty Seqec NO source pe qec 1 BCMA-1 BC 5G9 91 C7-11 VH CDR, sa NYDMA 2 BCMA-1 BC 5G9 91 2 CA1 C7-B1O VH CDR2 as SIITSGDATYYRDSVKG 3 BCMA-1 BC 5G9 91 C7-11 VH CDR3 as HDYYDGSYGFAY 4 BCMA-1 BC 5G9 91 C7-11 VLCDR1 as KASQSVGINVD 5 BCMA-1 BC 5G9 91 ___ _______C7-11 VL CDR2 as GASNRHT 6 BCMA-1 BC 5G9 91- LD3a LYGIF _________C7-B1O LD3a QGIF 7 BCMA-1 BC 5G9 91- VH aa QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR C7-1310 as FTISRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVsS 8 BCMA-1 BC SG9 91 A a EIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSG3 C7-B10 GREFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASI ITSGDATYYRDSVKGR BC 5G9 91- FTISRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG 9 BCMA-1 C7-11 scFv aa GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGREFTLTISSLQSEDFAVYYCLQYGS IPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGETrFSNYDMAWVRQAPGKGLEWVAS IITSGDATYYRDSVKGR FTI SRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BCMAl HL BC 5G9 91- GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQOKPGQAPRLLIYGASNRHTGIPARFSGS 1 C3- HLx C7-1310 HL bispecific aa GSGREFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK CD L x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYI SYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSc3NYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL I'l1 BCMA-2 BC 5G9 91- V DIa YM C7-DB IHDR aINY 12 BCMA-2 BC 5G9 91- V D2a ITGMYRSK C7-D8 HD2a 1TGr~YRSK 13 BCMA-2 BC 5G9 91 C7.D8 VH CDR3 aa H-DYYDGSYGFAY 14 BMA-2 BC 5G9 91 1 CA2 C7-D8 VLCDR1 88 KASQSVGINVD 15 BCMA-2 BC 5G9 91- LD2a GANH C7-D8 1LDR 1aGSN 16 BCMA-2 BC 5G9 91- VLCDR3 aa LQYGSIPFT C7-D8 __________________________________ 17 BCA2 BC 5G9 91- VH aa QVQLVESGGGVVQPGRSLRLSCAASG1'TFSNYDMAWVRQAPGKGLEWVASI ITSGDMTYYRDSVKGR BCA2 C7-DB FTISRDNSKNTLYLQNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 1s BCMA-2 BC 5G9 91- VL a EIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGI PARFSGSGS C7-D8 VL - GREFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGT<VDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVAS IITSGDMTYYRDSVKGR 19 BCA- BC 5G9 91- -c~ a FTISRDNSKNTLYLQNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG C7-D8 00 GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSCREFTLTI SSLQSEDFAVYYCLQYGSI PFTFGPGTKVDI I QVQLVESGGGVVQPCRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVAS IITSGDMTYYRDSVKGR FTI SRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGsGGG BC5G91-GSEI VMTQSPATLSVSPGERVTLSCKASQSVGINVDWYCQKPGQAPRLLIYGASNRHTGI PARFSGS 20 BCMA-2 HLX x *7D8 H~L bispecific a GSGREFTrLTISSLQSEDFAVY'YCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSL< C0 H CD3 HL molecule LSCAASGE'TFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYITSYWAYWCQGTLVT VSSGGGGSGGGGSGGGGSQTVVTQEPS LTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 21 BCMA-3 B G 1O VH CDR1 88 NYDMA 22 BCMA-3 BC 5G9 91- VH CDR2 aa SIITSGDATYYRDSVKG E4-11 23 BCMA-3 BC 5G9 91- VH CDR3 88 HDYYDGSYGFAY E4-11 24 BCMA-3 BC5G9 91- ALCDR1 aa KASQSVGINVD _____~~~ ______ 4B1O 25 BCMA-3 BC 5G9 91- VL CDR2 aa GASNRHT E4-81 0____________________________________ BC 5G9 91 26 BCMA-3 E4-B10 VL CDR3 aa LQYGSIPFT 27 BCMA-3 BC 5G9 91- VH aa QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR E4-B10 FTISRDNSKNTLYLQNNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 28 BCMA-3 BC 5G9 91- VL aa EIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS E4-B10 GTEFTLTISSLQSEDFAVYYCLQYGSIPFTE'GPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR 29 BCMA-3 BC 5G9 91- scFv aa FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG E4-B10 GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC5G991- GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS 30 BCMA-3 HL x E4-B10 HL bispecific __ GSGTEFrLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 31 BCMA-4 BC 569 91- VHCDR1 aa NYDMA E4-D8 32 BMA.4 BC 569 91 32 BCMA-4 BC VHCDR2 aa SIITSGDMTYYRDSVKG 33 BCMA-4 5991- VH CDR3 aa HDYYDGSYGFAY BCMA-4 E4-08 34 BCMA-4 VL CDR1 aa KASQSVGINVD 35 BCMA-4 BC 569 91 E4-D3 VL CDR2 aa GASNRHT 36 BMA-4 BC 569 91 36 BCMA-4 BC VL CDR3 aa LQYGSIPFT 37 BCMA-4 BC 5G991- VH aa QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR E4-DB FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 38 BCMA-4 BC 5G9 91- VL aa EIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS E4-D8 GTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR 39 BCMA-4 BC 5G9 91- scFv aa FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG E3-D8 GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC5G991- GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS 40 BCMA-4 HL x B bispecific GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV _QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 41 BCMA-5 BC991- VH CDR1 aa NYDMA 41 BMA-5 02-B310 42 BCMA-5 BC 5G991- VHCDR2 aa SIITSGDATYYRDSVKG D2-B 10 ____ 43 BCMA-5 BC 5G9 91 42-B1O VHCDR3 aa HDYYDGSYGFAY 44 BCMA-5 BC 5G991- VL CDR1 aa KASQSVGINVD 02-B 10 45 BMA-5 BC 5G9 91 42 BCMA-5 -B1O VL CDR2 aa GASNRHT 46 BCMA-5 BC G991- VLCDR3 aa LOYGSIPFT ______ 2-B1 10 CR a QGSP 47 BCMA-5 BC 5G9 91- VH aa QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR D2-B10 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 48 BCMA-5 BC 5G9 91- VL aa EIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS D2-B1O GTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR 49 BCMA-5 BC SG9 91- scFv aa FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG D2-B1O GSEIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS

GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK

QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC5G991- GSEIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS S BCMA-5 HL1x bi c a GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK xCD3HL mdecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV OPEDEAEYYCVLWYSNRWVFGGGTKLTVL 51 BCMA-6 BC5G991- VH CDR1 aa NYDMA 52 BCMA-4 BC5G991- VHCDR2 aa SIITSGDMTYYRDSVKG 53 BC B 5G991 VH CDR3 sa HDYYDGSYGFAY 54 BCMA4 BC5G991- VLCDR1 aa KASQSVGINVD BCM-6 2-D81 66 BCMA- BC 5G9 91- VLCDR2 aa GASNRHT 02-08 VC 56 BCMA-6 BC 5G9 91- VLCDR3 aa LQYGSIPFT 02-08 V D3s QGIF 57 BCMA4 BC 5G9 91- VH aa QVQLVESGGGVVQPGRSLRLSCAASGPTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR D2-D8 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 58 BCMA4 BC 5G9 91- VL aa EIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS D2-D8 GTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR 59 BCMA4 BC 5G9 91- FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG D2-D8 scFv a GSEIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR BCMA-4 HL x BC 5G9 91- FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG 60 CD3HL D3DHL mdecule aa GSEIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS xCD3HL GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK I_ __ I I LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 61 BCMA-7 BC 5G9 92- VH CDR1 aa NYDMA E10-BIO VHD1a NYA 62 BCMA-7 BC 5G9 92 EIO-BlO VH CDR2 aa SIITSGDATYYRDSVKG 63 BCMA-7 BC 5G9 92- VH CDR3 aa HDYYDGSYGFAY 64 BCMA-7 BC 5G9 92 E60-BlO VL CDR1 aa KASQSVGINVD 66 BCMA-7 BC 5G9 92- VL CDR2 aa GASNRHT EIO-BlO V D2a ANH 66 BCMA-7 B19092- VL CDR3 aa LQYGSIPFT 67 BCMA-7 BC 5G9 92- VH aa QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR EIO-B1O FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 68 BCMA-7 BC 5G9 92- VL aa EIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS E1O-B1O GTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFrFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR 69 BCMA-7 BC 5G9 92- scFV aa FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWCQGTLVTVSSGGGGSGGGGSGGG E1O-B1O GSEIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFrFSNYDMAWVRQAPGKGLEWVASIITSGDATYYRDSVKGR FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG GSEIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS 7H BC 5G9 92- bispecific GSGTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK 70 BCD3-HLx ElOB10 HL bisp CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 71 BCMA-8 BC 5G9 92- VH CDR1 a NYDMA E10-D8 VHD1 a NYM 72 BCMA-8 5G992- VHCDR2 aa SIITSGDMTYYRDSVKG 73 BCMA-8 BC 5G9 92- VH CDR3 aa HDYYDGSYGFAY _________E1O-DS HC 74 BCMA-8 BC 5G9 92 E 1 O-B8 VLCDR1 aa KASQSVGINVD 75 BCMA-8 BC 5G9 92- VL CDR2 aa GASNRHT E1O-D8 VLDR 1aGSN 76 BCMA-8 BC 5G9 92- V CDR3 aa LQYGSIPFT EIO-D8 VLD3a LQGPF 8 BC5G992- VQVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR 77 BCA- 5G9O92- VH aa E10-D8 FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 78 BCMA-8 BC 5G9 92- VL aa EIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS E1O-D8 GTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR 79 BCMA-8 BC 5G9 92- scFv aa FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG E1O-08 GSEIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIK OVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGDMTYYRDSVKGR FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC5G992- GSEIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS so BCMA-8 HL x E10-D8 HL bispecific a GSGTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRF-rISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 81 BCMA-9 BC H 38- VH CDR1 aa NYWIH ___ ~~D2-A4 VCDla NYI 82 BCMA-9 BH1 38- VH CDR2 aa AIYPGNSDTHYNQKFQG BC Hi 38 83 BCMA-9 D2-A4 VH CDR3 aa SSYYYDGSLFAS 84 BCMA-9 BCHl 38- VL CDR1 aa RSSQSIVHSNGNTYLY D2-A4 85 BCMA-9 BC H1 38- VL CDR2 aa RVSNRFS D2-A4 VC BC Hi 38 86 BCMA-9 D2-A4 VL CDR3 aa FQGSTLPFT 87 BCMA-9 BC H1 38- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGORLEWIGAIYPGNSDTHYNQKFQGK D2-A4 VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSS 88 BCMA-9 BC HI 38- DIVMTQTPLSLSVSPGQPASISCRSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF D2-A4 VL as SGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK BC H138- VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG 89 BCMA-B D2-A4 scFv an GSDIVMTQTPLSLSVSPGQPASISCRSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG BC H138- GSDIVMTQTPLSLSVSPGQPASISCRSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD 90 BCMA-9 HL x D2-A4 HL bispecfic an RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP CD3 HL x CD3 HL molecule GGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAAL TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 91 BCMA-10 BC H1 VH CDR1 aa NYWIH D2-Fi2 VH 92 BCMA-10 BCHi38- VH CDR2 aa AIYPGNSDTHYNQKFQG D2-Fi2 93 BCMA-1O B 38- CDR3 aa SSYYYDGSLFAS 94 BCMA-10 BC2 VL CDR1 aa RSSQSIVHSNGNTYLY 95 BCMA-10 BC H 38- VLCDR2 aa RVSNRFS D2-Fi2 VC 96 BCA-iO BC HI 38 96 BCMA-10 D2-F12 VL CDR3 aa FQGSHLPFT BC H1 38 97 BCMA-10 D2-F12 VH aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSS 98 BCMA-10 BCHI 38- VL aa DIVMTQTPLSLSVSPGQPASISCRSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF D2-F12 SGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK BC HI 38- scFv aa VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG 99 BCMA-10 D2-F12 GSDIVMTQTPLSLSVSPGQPASISCRSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG BC H1 38- GSDIVMTQTPLSLSVSPGQPASISCRSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD 100 BCMA-10 HL x D2-F12 HL bispecific RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP CD3 HL x CD3 HL molecule GGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAAL TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 101 BCMA-11 BCH1 38- VH CDR1 aa NYWIH C1-A4 VCD1 8 NYI 102 BCMA-1 1 BC H1 38 C1-A4 VH CDR2 aa AIYPGNSDTHYNQKFQG 103 BCMA-11 BC Hi 38- VH CDR3 aa SSYYYDGSLFAS C1-A4 104 BCMA-11 BCH1 38- VL CDR1 aa KSSQSIVHSNGNTYLY ______ CI-A4 II 105 BCMA-11 BC H1 38- VL CDR2 aa RVSNRFS C1-A4 106 BCMA-11 BH1 8- VL CDR3 aa FQGSTLPFT 107 BCMA-11 BC H1 38- QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK C1-A4 \H 88 VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSS 108 BCMA-11 BC H1 38- VL aa DIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF C1-A4 SGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIK BC H138 109 BCMA-11 C1-A4 scFv aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD 110 BCMA-11 HLx C1 HL bispe aa RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP CD3HL x CD3 HL molecule GGSLKLSCAASGFTFNKYANNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAAL TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL Ill BCMA-12 BCHl3- VHCDR1 aa NYWIH Cl-F12 112 BCMA-12 BCH13- VHCDR2 aa AIYPGNSDTHYNQKFQG 113 BCMA-12 BCHI38- VHCDR3 aa SSYYYDGSLFAS C i-F12 114 BCMA-12 BCH138- VLCDR1 aa KSSQSIVHSNGNTYLY Cl-F12 I_________________________I___________ 115 BCMA-12 SCHi38- VLCDR2 aa RVSNRFS 116 BCMA-12 BC H13 VLCDR3 aa FQGSHLPFT 117 BCMA-12 BC H13 VH aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK C1-F12 VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSS 118 BCMA-12 BC H13 VL aa DIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF C1-F12 SGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK 119 BCMA-12 BC Hi3 sFv aa VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG C1-F12 GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK BC H1 38 120 BCMA-12 HLx C1-F12 HL bis38 ci- c QVQLVQSGAEVKKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGK CD3HL xCD3 HL molecule VTITRDTSASTAYMELSSLTSEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP GGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAAL TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 121 BCA-1 3 BC Hi 39 121 BCMA-13 B VHCDR1 aa NYWIH 122 BCMA-13 BCH13 VHCDR2 aa AIYPGNSDTHYNQKFQG BC Hi 39 123 BCMA-13 B2A4 VHCDR3 aa SSYYYDGSLFAS 124 BCMA-13 BC H139 VLCDR1 aa KSSQSIVHSNGNTYLY 125 BCMA-13 BC H1 39- VLCDR2 as RVSNRFS B2-A4 126 BCMA-13 BCH1 39- VLCDR3 aa FQGSTLPFT B2-A4 LD3a QSPF 127 BCMA-13 BC H139- VH aa QVQLVQSGAVVAKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWMGAIYPGNSDTHYNQKFQGR B2-A4 VTLTTDTSASTAYMELSSLRNEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSS 128 BCMA-13 BC H139- VL as DIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF B2-A4 SGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIK QVQLVQSGAVVAKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWMGAIYPGNSDTHYNQKFQGR 129 BCMA-13 BC H1 39- scFv aa VTLTTDTSASTAYMELSSLRNEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG B2-A4 GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIK QVQLVQSGAVVAKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWMGAIYPGNSDTHYNQKFQGR VTLTTDTSASTAYMELSSLRNEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG BCM-13HLx BC H139 bp c GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD CD3 HL 4 molecule aa RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP x CD3 HL GGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP

SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAAL

TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 131 BCMA-14 BC HI 39- VH CDR1 aa NYWIH B2-F12 VH 132 BCMA-14 B2-F239- VH CDR2 aa AIYPGNSDTHYNQKFQG B2F12 VH 133 BCMA-14 BC H 39- VH CDR3 aa SSYYYDGSLFAS B2-F12 134 BCMA-14 -F1239- VL CDR1 aa KSSQSIVHSNGNTYLY F12 VLC 135 BCMA-14 Hi 39- VL CDR2 aa RVSNRFS 2F 12 1L1 136 BCMA-14 -Hi 39- V CDR3 aa FQGSHLPFT B2F12 VC 137 BCMA-14 BC Hi 39- VH aa QVQLVQSGAVVAKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWMGAIYPGNSDTHYNQKFQGR B2-F12 VTLTTDTSASTAYMELSSLRNEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSS BC H1 39- DIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF 138 BCMA-14 B2-F12 VL aa SGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK QVQLVQSGAVVAKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWMGAIYPGNSDTHYNQKFQGR 139 BCMA-14 BC Hi 39- scFv aa VTLTTDTSASTAYMELSSLRNEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG B2-F12 GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK QVQLVQSGAVVAKPGASVKVSCKASGYTFTNYWIHWVKQAPGQRLEWMGAIYPGNSDTHYNQKFQGR VTLTTDTSASTAYMELSSLRNEDTAVYYCTRSSYYYDGSLFASWGQGTLVTVSSGGGGSGGGGSGGG BC H139- GSDIVMTQTPLSLSVTPGQQASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD 140 BCMA-14 HL x B2-F12 HL bispecific RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP CD3 HL x CD3 HL molecule GGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGL IGGTKFLAPGTPARFSGSLLGGKAAL TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 141 BCMA-15 BC H1 39- VH CDR1 aa SYWIH C9-A4 3 V 2 I 142 BCMA-15 BC Hi 39- 1V DR2 C9Aa- AIYPGNSDTHYNQKFQG 143 BMA-15 BC Hi 39 143 BCMA-15 C9-A4 VH CDR3 aa SSYYYDGSLFAD 144 BCMA-15 BC H1 3- VLCDR1 aa KSSQSIVHSNGNTYLY 145 BCMA-15 BC Hi 39 VLCDR2 aa RVSNRFS 146 BCMA-15 BC Hi 39- V CDR3 aa FQGSTLPFT C9-A4 I CDR a1FGSL 147 BCMA-15 BC Hi 39- VH aa QVQLVQSGAEVKKPGTSVKVSCKASGYTFTSYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGR C9-A4 VTLTRDTSASTAYMELSSLRSEDSAVYYCTRSSYYYDGSLFADWGQGTLVTVSS 148 BCMA-15 BC HI 39- V aa DIVMTQTPLSLSVTPGQPASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF C9-A4 SGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTGQGTKLEIK QVQLVQSGAEVKKPGTSVKVSCKASGYTFTSYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGR 149 BCMA-15 BC HI 39- scFv aa VTLTRDTSASTAYMELSSLRSEDSAVYYCTRSSYYYDGSLFADWGQGTLVTVSSGGGGSGGGGSGGG C9-A4 GSDIVMTQTPLSLSVTPGQPASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIK QVQLVQSGAEVKKPGTSVKVSCKASGYTFTSYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGR VTLTRDTSASTAYMELSSLRSEDSAVYYCTRSSYYYDGSLFADWGQGTLVTVSSGGGGSGGGGSGGG xBC Hi 39-GSDIVMTQTPLSLSVTPGQPASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD 150 BCMA-15 HL C9-A4 HL bispecific RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSTLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP CD3 HL x CD3 HL molecule GGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAAL TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 151 BCMA-16 BC Hi 39- Dis YT C9-F12 VH CDR1 aa SYWIH 152 BCMA-16 9-F1i239- VH CDR2 aa AIYPGNSDTHYNQKFQG 152 BMA-16 C9-F12 C9-F239- VH CDR3 aa SSYYYDGSLFAD 154 BCMA-16 BC Hi 39- VLCDRi aa KSSQSIVHSNGNTYLY C9-F12 VLCD 155 BCMA-16 BC Hi 39- VL CDR2 aa RVSNRFS C9-F12 156 BCMA-16 C9-F239- CDR3 aa FQGSHLPFTr 157 BCMA-16 BC H1 39- VH aa QVQLVQSGAEVKKPGTSVKVSCKASGYTFTSYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGR C9-F12 VTLTRDTSASTAYMELSSLRSEDSAVYYCTRSSYYYDGSLFADWGQGTLVTVSS 158 BCMA-16 BC H1 39- VL aa DIVMTQTPLSLSVTPGQPASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPDRF C9-F12 SGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK QVQLVQSGAEVKKPGTSVKVSCKASGYTFTSYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGR 159 BCMA-16 BC H139- VTLTRDTSASTAYMELSSLRSEDSAVYYCTRSSYYYDGSLFADWGQGTLVTVSSGGGGSGGGGSGGG C9-F12 scFv aa GSDIVMTQTPLSLSVTPGQPASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIK QVQLVQSGAEVKKPGTSVKVSCKASGYTFTSYWIHWVKQAPGQRLEWIGAIYPGNSDTHYNQKFQGR VTLTRDTSASTAYMELSSLRSEDSAVYYCTRSSYYYDGSLFADWGQGTLVTVSSGGGGSGGGGSGGG BC H1 39- GSDIVMTQTPLSLSVTPGQPASISCKSSQSIVHSNGNTYLYWYLQKPGQPPQLLIYRVSNRFSGVPD BCMA-16 HL x C H bispecific a RFSGSGSGTDFTLKISRVEAEDVGVYYCFQGSHLPFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQP 160 D3L C9-F12 HL bisec CD3 HL x CD3 HL molecule GGSLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTA YLQMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEP SLTVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAAL TLSGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 161 BCMA-17 BC C3 33- VH CDR1 aa NFDMA 162 BCMA-17 B C333- VHCDR2 aa SITTGADHAIYADSVKG 163 BCMA-17 BC C3 33 163 D7E6 VH CDR3 aa HGYYDGYHLFDY 164 BCMA-17 BC C3 33- VLCDR1 aa RASQGISNYLN D7. E6 165 BCMA-17 BC C3 3 VLCDR2 aa YTSNLQS 166 BMA-i7 BC C3 33 166 BCMA-17 D7-E VL CDR3 aa QQYDISSYT 167 BCMA-17 BC C3 33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR D7-E6 FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 168 BCMA-17 BC C3 33- VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS D7-E6 GTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR 169 BCMA-17 BC C3 33- scFv aa FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG D7-E6 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC C333- GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 170 BCMA-17 HL x D7-E6 HL bispecific GSGTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL BC C3 33 171 BCMA-18 D7-E6B1 VH CDR1 aa NFDMA 172 BCMA-18 BD36B1 VH CDR2 aa SITTGADHAIYADSVKG 173 BC D-E6B VH CDR3 aa HGYYDGYHLFDY 174 BCMA-18 BC C333- VLCDR1 aa RASQGISNYLN 176 BCMA-18 B VL CDR2 aa YTSNLQS 176 BCMA-18 D7-E6BI VL CDR3 aa MGQTISSYT 177 BCMA-18 BC C3 33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR D7-E6B1 FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 178 BCMA-18 BC C3 33- VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS D7-E6B1 GTDYTLTISSLOPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR 179 BCMA-18 BC C3 33- scFv 88 FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG D7-E6B1 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS

GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK

EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC C3 33 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 180 BCMA-18 HLx D7-E6B1 bispecific aa GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK 80 CD3HL HLxCD3 molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN HL NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 181 BCMA-19 BCC3 33- VH CDR1 aa NFDMA _________ E6 VH 182 BCMA-19 C333- VHCDR2 aa SITTGADHAIYADSVKG 8EC333- VH CDR3 aa HGYYDGYHLFDY 184 BCMA-19 BC C3 33- VLCDR1 aa RASQGISNYLN F8-E6 ____ ______________________________________ 185 BCMA-19 BCC333- VLCDR2 aa YTSNLQS 185 BCMA-19 BCC3- 3 1 C333- VCDR3 aa QQYDISSYT 187 BCMA-19 BC C3 33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR F8E6 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 188 BCMA-19 BC C3 33- VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLTYYTSNLQSGVPSRFSGSGS F8-E6 GTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR 189 BCMA-19 BC C3 33- sFv FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG F8-E6 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR BCMA-19 HLx BC C3 33- bispecific FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG 190 CD3 HL F8-E6 HL molecule aa GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS x CD3 HL GSGTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK

LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN

NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 191 BCMA-20 VH CDR1 aa NFDMA 192 BCMA-20 B VH CDR2 aa SITTGADHAIYADSVKG F8-E6B1 193 BCMA-20 BC C3 33- VH CDR3 aa HGYYDGYHLFDY FB-E6B1 194 BCMA-20 BC C3 33- VL CDR1 aa RASQGISNYLN F8-E6B1 195 BCMA-20 B VL CDR2 aa YTSNLQS BC C3 33 196 BCMA-20 F8-EBB1 VL CDR3 aa MGQTISSYT 197 BCMA-20 BC C333- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR F8-E6B1 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS BC C333- DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS 198 BCMA-20 F8-E6B1 VL 88 GTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR 199 BCMA-20 BCC333- sFv 28 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG F8-E6B1 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC C333- GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 200 BCMA-20 HL x F8-E6B1 bispecific GSGTDYTLT ISSLQPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL HL x CD3 molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN HL NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 201 BCMA-21 C 03 33- VH CDR1 aa NFDMA F9-E6 202 BCMA-21 BC C3 33- VH CDR2 aa SITTGAOHAIYADSVKG F9- E6 203 BCMA-21 BC C3 6 VH CDR3 aa HGYYDGYHLFDY 204 BCMA-21 BC C3 33 ___F9-E6 VL CDR1 aa RASQGISNYLN 205 BCMA-21 BC-E C3 R2 aa YTSNLQS 206 BCMA-21 BC C3 33- R3 a OQDSY ___F9-E6 VL CDR3a QDSY 207 BCMA-21 BC C3 33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYADSVKGR F9-E6 FTI SRDNAKrNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 28 BM21 BC C3 33- V a DlQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS 208 BCM-21 FS-E6 V a GTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGTFSNFDIAWVRQAPGKGLVWVSS ITTGADHAIYADSVKGR BC C3 33- sv a FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG 209 BCMA-21 F9-E6 cv B GSDIQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVsSSITTGADHATYADSVKGR FTI SRDNAKNTLYLQM.DSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC C 33-GSDIQMTQ3PSSLSASVGDRVTI SCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 210 BCMA-21 HL x F9-E6 HL bispecific GSGTDYTLTISSLQPEDFATYYCQQYDISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD L x CD3 HL molecule aa LSCAASC3FTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTrISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGN FGNSY ISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWJYSNRWVFGGGTKLTVL 211 BCMA-22 BC9C3633- VH CDR1 aa NFDMA 212 BCMA-22 BC C3 33- V DR2 aa SITTGADHAIYAESVKG F9-E6B1-E V 213 BMA-22 BC C3 33 21 BMA22 F9-E6B1-E VH CDR3 aa HGYYDGYHLFDY 214 BCMA-22 B C C,33 3 F9-E_1E ALCDR1 Ba ASQGISNYLN 215 BMA-22 BC C3 33 21 BCMA-22 F9-E61-E VL CDR2 aa YTSNLQS 216 BCMA-22 CC3B-E VLCDR3 a MGQTISSYT 217 BCMA-22 BC C3 33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYAESVKGR FS-E681-E FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 218 BCMA-22 BCC333 VL aa DIQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS F9-E6B1-E GTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFEFSNEDMAWVRQAPGKGLVWVSSITTGADHAIYAESVKGR 219 BCMA-22 BC C3 33 v FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG F9-E6B1-E GSDIQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGADHAIYAESVKGR FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC C333- GSDIQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 220 BCMA-22 HL x F9-E6Bi-E bispecific GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL HLx CD3 molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN HL NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 221 BCMA-23 BC C3 33- Ri8 NFA 221 BCMF10-E6B1 VH CDR1 aa NFDMA 222 BCMA-23 BC C3 33- VHCDR2 aa SITTGADHAIYADSVKG FiO-E6B1 223 BCMA-23 BC C3 V3- R3 GYYDGYHLFDY F1O-E6Bi VH CDR a HYDHLY 224 BCMA-23 6 VLCDRi aa RASQGISNYLN 225 BMA-23 BC C3 33 225 BCMA-23 6 VL CDR2 aa YTSNLQS 226 BCMA-23 BCC3 VL CDR3 a MGQTISSYT FC-EB 227 BCMA-23 BC C3 VH aa EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGADHAIYADSVKGR F1O-E681 W FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 228 BCMA-23 BC C33 VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS F1O-E6B1 GTDFTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGADHAIYADSVKGR 229 BCMA-23 BC C3 3 scFv aa FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG F1-E6B1 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGADHAIYADSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGOGTLVTVSSGGGGSGGGGSGGG BC C333- GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 230 BCMA-23 HLx F1O-E6B1 bispecific GSGTDFTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL HL x CD3 molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN HL NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 231 BCMA-24 BC B6 64- VHCDRI aa DYYIN H5-A4 232 BCMA-24 BC B6 64 H2-A4 VH CDR2 aa WIYFASGNSEYNQKFTG 233 BCMA-24 BC B6 64- VHCDR3 a LYDYDWYFV HS-A4 HCR a LDDYO 234 BCMA-24 BC B6 64- VLCDR1 aa KSSQSLVHSNGNTYLH H5-A4 II 235 BCMA-24 BC B6 64- VLCDR2 aa KVSNRFS HS-A4 236 BCMA-24 A VLCDR3 aa AETSHVPWT 237 BCMA-24 BC B6 64- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR H5-A4 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 238 BCMA-24 BC B664 VL a DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF HS-A4 SGSGSGTDFTLKINRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK 239 BCMA-24 BC 6 64 j Fv aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR HS-A4 ___ VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKTNRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC B6 64- DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 240 BCMA-24 HL x HA4HL bispedfic aa SGSGSGTDFTLKINRVEAEDVGVYYCAETSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 241 BCMA-25 BC B6 64- VH CDRI aa DYYIN HS-1-9 242 BCMA-25 BCB664 VH CDR2 aa WIYFASGNSEYNQKFTG 243 BCMA-25 BC B66 VHCDR3 aa LYDYDYFDV 1-5-1-9 HCR a LDWYV 244 BCMA-25 BC B6 64- VLCDR1 aa KSSQSLVHSNGNTYLH HS-H9 245 BCMA-25 BC B6 64- VLCDR2 as KVSNRFS 246 BCMA-25 BC B6 64 2-B5-A29 VL CDR3 aa LTTSHVPWT 247 BCMA-25 BC B664- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 1H5-1H9 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 248 BCMA-25 BC B664- VL aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLKPGSPOLLIYKVSNRFSGVPDRF HS-H9 SGSGSGTDFTLKINRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 249 BCMA-25 BC B6 64- scFv aa VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTNVTVSSGGGGSGGGGSGGGGS H5-H9 DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKINRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIK BCM-2 H ~ BC B6 64 20 BCMA-25 HL x HH9 HL bispecific QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR CD3HL xCD3 HL mdecule VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKINRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 251 BCMA-26 BCB665- VHCDR1 aa DYYIN ______BS-A4 ___ORI____ YI 252 BCMA-26 BCB665- VHCDR2 aa WIYFASGNSEYNQKFTG ______B5-A4 _______GSENQFT 253 BCMA-26 BCB665- VHCDR3 aa LYDYDWYFDV ____ ________B5-A4 254 BCMA-26 65 VLCDR1 aa KSSQSLVHSNGNTYLH 255 BCMA-26 BC B6 65- V CDR2 aa KVSNRFS B5-A4 V D2a VNF 256 BCMA-26 BC B665- VLCDR3 aa AETSHVPWT 85-A4 I 257 BCMA-26 BCB665- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKETGR B5-A4 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 258 BCMA-26 BCB665- VL aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF B5-A4 SGSGSGTDFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 259 BCMA-2:6 BCB665- sv VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS B5-A4 scFv aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BCMA-26 HLx BCB665- bispec DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF CD3 HL B5-A4 HL mecule aa SGSGSGTDFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG x CD3 HL SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL

TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL

SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 261 BCMA-27 BC B6 65- VH CDR1 aa DYYIN 135-1-9 V D 1 a Y I 262 SCMA-27 BC 86 65 B5-H9 VH CDR2 aa WIYFASGNSEYNQKFTG 263 BCMA-27 BC B6 65- VH CDR3 aa LYDYDWYFDV 264 BCMA-27 BC B6 65- VLCDR1 aa KSSQSLVHSNGNTYLH B5-H9 1 265 BCMA-27 BC 8665- VL CDR2 aa KVSNRFS 135-1-9 266 BMA-27 BC B6 65 266 BCMA-27 B5-H9 VLCDR3 aa LTTSHVPWT 267 BCMA-27 BC B665- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR B5-H9 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 268 BCMA-27 BC B665- VL aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF B5-H9 SGSGSGTDFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 269 BCMA-27 BC B665- scFv aa VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS B5-H9 DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 8665- DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 270 BCMA-27 HL B5-H9 HL bispecific SGSGSGTDFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 271 BCMA-28 B 86 65- VH CDR1 aa DYYIN 272 BMA-28 BC B6 65 272 BCMA-28 H7-A4 VHCDR2 aa WIYFASGNSEYNQKFTG 273 BCMA-28 VH CDR3 aa LYDYDWYFDV 274 BCMA-28 BC B6 65 H7-A4 VLCDR1 aa KSSQSLVHSNGNTYLH 276 BCMA-28 BC 86 65 H7-A4 VL CDR2 aa KVSNRFS 276 BCMA-28 BC 86 65- V CDR3 aa AETSHVPWT IH7-A4 1LDR sa ATSV 277 BCMA-28 BC B6 65- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR H7-A4 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 278 BCMA-28 BC B665- V aa DIVMTQTPLSLSVSPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF H7-A4 SGSGSGTDFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR BC B665- VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS 279 BCMA-28 H7-A4 DIVMTQTPLSLSVSPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC B665- DIVMTQTPLSLSVSPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 280 BCMA-28 HL x H7-A4 HL bispecific SGSGSGTDFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule aa SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 281 BCMA-29 BC B6 65- VH CDR1 as DYYIN H7-H9 vHD1a YI 282 BCMA-29 BC 86 65 H7-H9 VHCDR2 aa WIYFASGNSEYNQKFTG 283 BCMA-29 BC B6 65 2 C 9 7-H9 VH COR3 aa LYDYDWYFDV 284 BCMA-29 B6 65- VL CDR1 aa KSSQSLVHSNGNTYLH 285 BCMA-29 B B6 65- VL CDR2 aa KVSNRFS H7-H9 286 BCMA-29 BC 86 65- VLCDR3 aa LTTSHVPWT ____ ~~H7-H9 VLD3a LTSVW 287 BCMA-29 BC B6 65- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR H7-H9 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 288 BCMA-29 BC B6 65- DIVMTQTPLSLSVSPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF H7-H9 VL SGSGSGTDFTLKISRVEAEDVGVYYCLTTSHVPWTFGGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 289 BCMA-29 BC B665- sFv aa VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS H7-H9 DIVMTQTPLSLSVSPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 6 65- DIVMTQTPLSLSVSPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 290 BCMA-29 HL x bispecific SGSGSGTDFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 291 BCMA-30 BC 86 65- VH CDR1 aa DYYIN ____ H8-A4 292 BCMA-30 BC B6 65- VH CDR2 aa WIYFASGNSEYNQKFTG ____ ~~H8-A4 VHD2a WIFSNYNKG 293 BCMA-30 BC B6 65- VH CDR3 aa LYDYDWYFDV HB-A4 294 BCMA-30 BC 86 65- VLCDRI aa KSSQSLVHSNGNTYLH __H8-A4 1L1 295 BCMA-30 BC B6 65- V CDR2 aa KVSNRFS ___ H8A4 VC 296 BCMA-30 BC B665- VLCDR3 aa AETSHVPWT 297 BCMA-30 BC 8665- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR H8-A4 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 298 BCMA-30 BC B665- VL aa DIVMTQTPLSLSVTPGEPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF H8-A4 SGSGSGADFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 299 BCMA-30 BC B6 65- scFv aa VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS HB-A4 DIVMTQTPLSLSVTPGEPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGADFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BCMA-30 HLx BC B665- DIVMTQTPLSLSVTPGEPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 300 C3 L H8-A4 HL bispecific aa SGSGSGADFTLKISRVEAEDVGVYYCAETSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 301 BCMA-31 BC B665- VHCDR1 aa DYYIN 118-H9 302 BCMA-31 BC8665- VH CDR2 aa WIYFASGNSEYNQKFTG 303 BCMA-31 BC B6 65- VH CDR3 aa LYDYDWYFDV 304 BCMA-31 BC 86 65- VL CDR1 aa KSSQSLVHSNGNTYLH 305 BCMA-31 BC8665- VLCDR2 aa KVSNRFS 306 BCMA-31 BC B665 H8-H9 VL CDRS as LTTSHVPWT 307 BCMA-31 BC B665- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR H8-H9 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 308 BCMA-31 BC B665- VL aa DIVMTQTPLSLSVTPGEPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF H8-H9 SGSGSGADFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 309 BCMA-31 BC B665- sc VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS H8-H9 Fv as DIVMTQTPLSLSVTPGEPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF

SGSGSGADFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIK

QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BCB665- DIVMTQTPLSLSVTPGEPAS ISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 310 BCMA-31 HL x H8-H9 HL bispecific a SGSGSGADFTLKISRVEAEDVGVYYCLTTSHVPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 311 BCMA-32 BC A7 27- VH CDR1 aa NHIIH A6-G7 VHD18 NIH 312 BCMA-32 BC A7 27- VH CDR2 aa YINPYPGYHAYNEKFQG ____ ________A6-G7 VHD2a YIPGYYEKG 313 BCMA-32 BC A7 27- VH CDR3 aa DGYYRDTDVLDY 314 BCMA-32 BC A7 27- V CDR1 aa QASQDISNYLN A6-G7 VLDI8 QSQSNN BC A7 27 315 BCMA-32 A6-G7 VL CDR2 aa YTSRLHT 316 BCMA-32 BC A7 27- VL CDR3 aa QQGNTLPWT 317 BCMA-32 BC A7 27- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYPGYHAYNEKFQGR A6-G7 ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSS 318 BCMA-32 BC A7 27- VL aa DIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGSGS A6-G7 GTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYPGYHAYNEKFQGR 319 BCMA-32 BC A7 27- ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG A6-G7 88 GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS GSGTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYPGYHAYNEKFQGR BCA7 27- ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG 320 BCMA-32 HL x BC67-H bispecific CD3 HL G7HL molecule aa GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS x CD3 HL GSGTDFTFT ISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK

LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN

NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 321 BCMA-33 BC A7 27- VH CDR1 aa NHIIH AS-Hi11 322 BCMA-33 BCA727- VH CDR2 aa YINPYDGWGDYNEKFQG 323 BCMA-33 BC A7 27- VH CDR3 aa DGYYRDADVLDY A6-HI1 324 BCMA-33 BC A7 27- VLCDR1 aa QASQDISNYLN AS-H 1 325 BMA-33 BC A7 27 325 BCMA-331 VL CDR2 aa YTSRLHT 326 BCMA-33 BC A7 27- VLCDR3 aa QQGNTLPWT AS-H 11 327 BCMA-33 BCA7 27- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYDGWGDYNEKFQGR A6-H11 ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSS 328 BCMA-33 BC A7 27- VL aa DIMTSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGSGS A6-H11 GTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHI IHWVRQAPGQGLEWMGYINPYDGWGDYNEKFQGR 329 BCMA-33 BC A7 27- ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG A6-H11 scFv aa GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS GSGTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYDGWGDYNEKFQGR ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG BC A7 27- GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS 330 BCMA-33 HL x A6-H11 HL bispecific a GSGTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 331 BCMA-34 BC A7 27- VH CDR1 aa NHIIH C4-G7 332 BCMA-34 BC A7 27- VHCDR2 aa YINPYPGYHAYNEKFQG C4-G7 VH 333 BCMA-34 BCA727- VHCDR3 as DGYYRDTDVLDY 334 BMA-34 BC A7 27 334 BCMA-34 CA7 VLCDR1 aa QASQDISNYLN 335 BCMA-34 BC A7 27- VLCDR2 aa YTSRLHT C4-G7 V D2a TRH 336 BCMA-34 BC A7 27- VL CDR3 aa QQGNTLPWT C4-G7 337 BCMA-34 BC A7 27- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYPGYHAYNEKFQGR C4-G7 ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSS 338 BCMA-34 BC A7 27- V aa DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGSGS C4-G7 GTDFTFTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYPGYHAYNEKFQGR 339 BCMA-34 BC A7 27- ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG C4-G7 scFv Ba GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS GSGTDFTFTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYPGYHAYNEKFQGR ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG BC A727- GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS 340 BCMA-34 HL C4-G7 HL aa GSGTDFTFTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL moecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 341 BCMA-35 BC VHCDR1 aa NHIIH _________C4-H1 1 VHD1a NIH 342 BCMA-35 VHCDR2 aa YINPYDGWGDYNEKFQG 343 BCMA-35 BC A7 27 343 CMA-52C4-H11 VH CDR3 as DGYYRDADVLDY 344 B VL CDR1 aa QASQDISNYLN 345 BCMA-35 BC A7 27- V CDR2 aa YTSRLHT C4-Hi1 LD2a TRH 346 BMA-35 BC A7 27 346 BCMA-35 VL CDR3 aa QQGNTLPWT 347 BCMA-35 BCA7 27- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYDGWGDYNEKFQGR C4-H11 ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSS 348 BCMA-35 BC A7 27- VL aa DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGSGS C4-H11 GTDFTFTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYT FTNHIIHWVRQAPGQGLEWMGYINPYDGWGDYNEKFQGR 349 BCMA-35 BC A7 27- ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG C4H11 BCMA-3GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS GSGTDFTFTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVKKPGASVKVSCKASGYTFTNHIIHWVRQAPGQGLEWMGYINPYDGWGDYNEKFQGR ATMTSDTSTSTVYMELSSLRSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG BC A727- GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS 350 BCMA-35 HL x C4-H11 HL bispecific GSGTDFTFTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 351 BCMA-36 BC A7 15- VHCDR1 aa NHIIH H2-G7 352 BCMA-36 BCA7 15- VH CDR2 aa YINPYPGYHAYNQKFQG H2-G7 353 BCMA-36 BC A7 15 H2-G7 VH CDR3 aa DGYYRDTDVLDY 354 BCMA-36 BCA7 15- VLCDR1 aa QASQDISNYLN _______H2-G7 1LDR aa1SDIN 355 BCMA-36 A7 15- VL CDR2 aa YTSRLHT 356 BCMA-36 BC A7 15 H2-G7 VLCDR3 aa QQGNTLPWT 357 BCMA-36 G715- VH aa QVQLVQSGAKVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWMGYINPYPGYHAYNQKFQGR U ~V~f.~U H2-G7 VTMTRDKSTSTVYMELSSLTSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSS 38 BCMA-36 BC A7 15- V aa DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGRAPKLLIYYTSRLHTGVPSRFSGSGS H2-G7 GTDYSFTISSLQPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAKVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWMGYINPYPGYHAYNQKFQGR 369 BCMA-36 BC A7 15- scFv aa VTMTRDKSTSTVYMELSSLTSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG H2-G7 GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGRAPKLLIYYTSRLHTGVPSRFSGS GSGTDYSFTISSLQPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAKVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWMGYINPYPGYHAYNQKFQGR VTMTRDKSTSTVYMELSSLTSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG BCA715- GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGRAPKLLIYYTSRLHTGVPSRFSGS 360 BCMA-36 HL xH2-G7 HL bispecific GSGTDYSFTISSLQPEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL xCD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFIISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 361 BCMA-37 BCA7 15 H2-H11 VH CDR1 as NHIIH 362 BCMA-37 B 7- 15- VH CDR2 aa YINPYDGWGDYNQKFQG 363 BCMA-37 1 VH CDR3 aa DGYYRDADVLDY 364 BCMA-37 BCA7 15- VL CDR1 aa QASQDISNYLN H2-H11 _________________________________ 365 BCMA-37 15- VL CDR2 aa YTSRLHT H2-H11 366 BCMA-37 BC A7 15 H2-H1 VLCDR3 aa QQGNTLPWT 367 BCMA-37 BC A715 VH aa QVQLVQSGAKVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWMGYINPYDGWGDYNQKFQGR H2-H11 VTMTRDKSTSTVYMELSSLTSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSS 368 BCMA-37 BCA715- VL a DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGRAPKLLIYYTSRLHTGVPSRFSGSGS H2-H1 1 GTDYSFTISSLQPEDIATYYCQQGNTLPWTFGQGTKVEIK 369 BCMA-37 BCA7 15- scFv aa QVQLVQSGAKVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWMGYINPYDGWGDYNQKFQGR H2-- 11 VTMTRDKSTSTVYMELSSLTSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGRAPKLLIYYTSRLHTGVPSRFSGS GSGTDYSFTISSLQPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAKVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWMGYINPYDGWGDYNQKFQGR VTMTRDKSTSTVYMELSSLTSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG BCA7 15- GSDIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGRAPKLLIYYTSRLHTGVPSRFSGS 370 BCMA-37 HL x H2-H11 HL bispecific aa GSGTDYSFTISSLQPEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 371 BCMA-38 BCA7 VH CDR1 aa NHIIH 372 BCMA-38 VH CDR2 aa YINPYPGYHAYNQKFQG 373 BCMA-38 BC 15- VHCDR3 aa DGYYRDTDVLDY 374 BCMA-38 BCA7 15- VLCDR1 as QASQDISNYLN H8-G7 375 BCMA-38 BC 715- V CDR2 aa YTSRLHT 376 BCMA-38 BCA7 15- VLCDR3 aa QQGNTLPWT H8- G7 a QNLW 377 BCMA-38 BCA7 15- VH aa QVQLVQSGAEVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWIGYINPYPGYHAYNQKFQGK H8-G7 VTMTRDTSTSTVYMELSSLTSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSS 378 BCMA-38 BCA7 15- V aa DIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGSGS H8-G7 GTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWIGYINPYPGYHAYNQKFQGK 379 BCMA-38 BC A7 15- scFv aa VTMTRDTSTSTVYMELSSLTSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG HS-G7 GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS GSGTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK BCAl715 380 BCMA-38 HL x H8-G7 HL bispecific aa QVQLVQSGAEVIKPGASVKVSCKASGYTPFTNHIIHWVRQKPGQGLEWIGYINPYPGYHAYNQKFQGK CD3 HL x CD3 HL molecule VTMTRDTSTSTVYMELSSLTSEDTAVYYCARDGYYRDTDVLDYWGQGTLVTVSSGGGGSGGGGSGGG xCD3HL GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS GSGTDFTFrISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL BH 15- VH CDR1 aa NHIIH 382 BCMA-39 15- VH CDR2 aa YINPYDGWGDYNQKFQG 383 BCMA-39 VH CDR3 aa DGYYRDADVLDY 384 BCMA-39 BC A7 15- VLCDR1 aa QASQDISNYLN ____ ~~H8-Hil 1 LDR 18 QSDIN 385 BCMA-39 BC A7 15- VL CDR2 aa YTSRLHT H8-HI1_________________________________ 386 BCMA-39 HB- 715- VL CDR3 aa QQGNTLPWT 387 BCMA-39 BCA7 15- VH aa QVQLVQSGAEVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWIGYINPYDGWGDYNQKFQGK HB-H11 VTMTRDTSTSTVYMELSSLTSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSS 388 BCMA-39 BC A7 15- VL aa DIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGSGS H8-H1 1 GTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWIGYINPYDGWGDYNQKFQGK 389 BCMA-39 BC A7 15- 8 VTMTRDTSTSTVYMELSSLTSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG H8-H11 scF GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS GSGTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGAEVIKPGASVKVSCKASGYTFTNHIIHWVRQKPGQGLEWIGYINPYDGWGDYNQKFQGK VTMTRDTSTSTVYMELSSLTSEDTAVYYCARDGYYRDADVLDYWGQGTLVTVSSGGGGSGGGGSGGG BCMA-39 HL x BC A7 15- GSDIQMTQSPSSLSASLGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYYTSRLHTGVPSRFSGS CD39HL x H8-11HL molecule aa GSGTDFTFTISSLQQEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK x CD3 HL LSCAASGFTFNKYANNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS

PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV

QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 391 BCMA-40 BC 7A4 96- VH CDR1 aa DYYIN D4-A 12 ___ 392 BCMA-40 BC 7A4 96- VH CDR2 as WIYFASGNSEYNQKFTG ____ _________ 4-A 12 ___ 393 BCMA40 BC 7A4 96- VHCDR3 aa LYDYDWYFDV 04-A 12 394 BCMA40 BC 7A4 96- VLCDR1 aa KSSQSLVHSNGNTYLH 04-A 12 ___ 395 BA VL CDR2 aa KVSNRFS 396 BCMA-40 BC 7A4 96- VLCDR3 as SQSSTAPWT 04-A 12 BC7A498- QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYTNWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 397 BCMA40 D4-A12 VH aa VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 398 BCMA-40 BC 7A4 96- VL aa DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF D4-A12 SGSGSGTDFTLKISRVEAEDVGVYYCSOSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFrGR 399 BCMA40 BC 7A498 scv aa VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS D4-A12 DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC7A498- DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 400 BCMA40 HL x D4-A12 HL bispecific a SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIKSGGGGSEVLVESGGGLVQPGG CD3 HL xCD3HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRErISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 401 BCMA-41 BC7A496- VHCDR1 as DYYIN 04-D7 402 BCMA-41 BC7A49 VHCDR2 as WIYFASGNSEYNQKFTG __________04-0 403 BCMA-41 BC7A496- VHCDR3 aa LYDYDWYFDV 04-D7 404 BCMA-41 BC 7A4 96 44-7 VLCDR1 aa KSSQSLVHSNGNTYLH 405 BCMA-41 BC 7A4 96- VL CDR2 aa KVSNRFS 04-07 LD2a VNF 406 BCMA-41 BC 496- VL CDR3 aa SQSSIYPWT 407 BCMA-41 BC 7A4 96- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR D4-D7 VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 408 BCMA41 BC 7A49- V aa DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF D4-D7 SGSGSGTDFTLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR BC 7A4 96- VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS 409 BCMA-41 04-D7 scFv aa DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC7A496- DIVMTQTPLSLPVTLGOPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 410 BCMA-41 HL x D4-D7 HL bispecific a SGSGSGTDFTLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 411 BCMA-42 BC 7A4 96- DR1 aa DYYIN D4-E7 VH CDIa YN 412 BCMA-42 BC 7A4 96 D4-E7 VHCDR2 aa WIYFASGNSEYNQKFTG 413 BCMA-42 BC4- 96 4 AE7 VHCDR3 aa LYDYDWYFDV 414 BCMA-42 BC 7A496- VLCDR1 aa KSSQSLVHSNGNTYLH 44- E7 V C 415 BCMA-42 BIC 7A4 9&I6- CR a VNF D4-E7 VIDR IaKSN 416 BCMA-42 BC 7A4 96 04-E7 ALCDR3 aa SQSTYPEFT 417 BCMA-42 BC 7A4 96- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFrGR D4-E7 VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 418 BCMA42 BC 7A4 96- V aa DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF D4-E7 SGSGSGTDFTLKISRVEAEDVGVYYCSOSTYPEFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 419 BCMA-42 BC 7A4 96- VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS D4-E7 scFv aa DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 7A4 96- DIVMTQTPLSLPVTLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 420 BCMA42 HLx DxE7HL bispecific SGSGSGTDFILKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG D3 CD3D3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 421 BCMA-43 BC 7A4 96- VH CDR1 aa DYYIN F4-A12 _______________________________ 422 BCMA-43 BC 7A4 96- VHCDR2 aa WIYFASGNSEYNQKFTG F4-A12 1HD2a IFSNENKT 423 BCMA-43 BC7A496- VHCDR3 aa LYDYDWYFDV __________F4-A12 424 BMA-43 BC 7A4 96 424 BCMA143 BCA2 VLCDR1 aa KSSQSLVHSNGNTYLH 425 BCMA-43 BC 7A4 96 ___ _______F4-A12 VA CDR2 88 KVSNRFS 426 BCMA-43 BC 7A496- VLCDR3 a SQSSTAPWT __________F4-A12 __________________________________ 427 BCMA-43 BC 7A4 96- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR F4-A12 VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 428 BCMA-43 BC 7A4 96 VL aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF F4-A12 SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 429 BCMA-43 BC 7A4 96- scFv an VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS F4-A12 DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 7A4 96- DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 430 BCMA-43 HLx F4-A12 HL bispecific aa SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 431 BCMA-44 BC7A4 96- VH CDR1 aa DYYIN F4-D7 432 BCMA-4 BC 7A49- VHCDR2 aa WIYFASGNSEYNQKFTG 433 BCMA-44 BC 7A4 96- VHCDR3 a LYDYDWYFDV F4-D7 VCR n LDDYD 434 BCMA-44 BCA496- VLCDR1 aa KSSQSLVHSNGNTYLH 435 BCMA-44 BC 7A496- VLCDR2 aa KVSNRFS __________F4-07 V D2a VNF 436 BCMA-44 BC7A496 VLCDR3 aa SQSSIYPWT 437 BCMA- BC 7A4 96- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR F4-D7 VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 438 BCMA-4 BC 7A4 96- VL aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF F4-D7 SGSGSGTDFTLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 439 BCMA44 BC 7A4 96- VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS F4-D7 sCFV an DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF

SGSGSGTDFTLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIK

QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC7A496- DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 440 BCMA-44HLx FD7 HL bicific aa SGSGSGTDFTLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 441 BCMA45 BC7A49- VHCDR1 aa DYYIN 442 BCMA-45 BC7A4 96- VHCDR2 a WIYFASGNSEYNQKFTG ___ F4E7 VH 443 BCMA-45 BC 7A496- VHCDR3 aa LYDYDWYFDV 44 BCMA-45 F4-E7 VH CDR1 aa KSSQSLVHSNGNTYLH 445 BCMA45 BC 7A4 96- VLCDR2 aa KVSNRFS ___ F4E7 VH BC7A49- VLCDR3 aa SQSTYPEFT 44 BCMA45 4QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR F-E7 VVTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 448 BCMA45 BC 7A4 96- VL aa DIVNTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF FA4E7 SGSGSGTDFTLKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 449 BCMA-45 BC7A49 scv VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS F4 VDIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR BCMA45HLx BC 7A496 bispeci c VTMTRDTSISTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS 450 CD3 HL F4-E7HL mecule aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF x CD3HL SGSGSGTDFTLKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG

_SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL

QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 451 BCMA-46 BC A4 VH CDR1 aa DYYIN 452 BCMA-46 7MA96- VH CDR2 aa WIYFASGNSEYNEKFTG 463 BCMA-46 7A96- VH CDR3 aa LYDYDWYFDV 454 BCMA-46 BC 7A4 96- VLCDR1 aa KSSQSLVHSNGNTYLH G2-A12 455 BCMA-46 BC 7A4 96- VLCDR2 aa KVSNRFS G2-A12 VLD2a KVNS 456 BCMA-46 BC 7A4 96 G2-A12 VLCDR3 aa SQSSTAPWT 457 BCMA-46 BC 7A4 96- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR G2-A12 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 458 BCMA46 BC 7A4 96- VL aa DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF G2-A12 SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR 459 BCMA-46 BC 7A4 96- VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS G2-A12 scFv aa DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 7A4 96- DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 460 BCMA-46 HL x G2-A12 HL bispecific SGSGSGTDFTLKISRVEAEDVGVYYCSQSSTAPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 461 BCMA-47 BC7A4 96- VH CDR1 aa DYYIN ______________G2-D7 462 BCMA-47 BC 7A4 96 G2-07 VH CDR2 aa WIYFASGNSEYNEKFTG 463 BCMA-47 BC-796 VH CDR3 aa LYDYDWYFDV 464 BCMA-47 BC 7A4 96 G2-D7 VLCDRI aa KSSQSLVHSNGNTYLH 465 BMA-47 BC 7A4 96 46 CM-7 G2-D7 VL CDR2 aa KVSNRE'S 466 BCMA-47 BC 7A4 96 G2-D7 VLCDR3 aa SQSSIYPWT 47 BM-7 BC 7A4 96- V a QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR 467 BMA-47 G2-D7 V aa VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 48 BM-7 BC 7A4 96- V a DIVMTQTPLSLSVSLGQPASISCKSSQSLVH-SNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF G2-D7 VLSGSGSGTDFTLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYS FPDYYI NWVRQAPGQGLEWMGW IYFASGNSEYNEKFTGR 469 BCA4 BC 7A4 96- sv aa VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS G2-D7 sv a DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHlWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTrLKI SRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYS FPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCAS LYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 7A 96-DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 470 4 H C A 6 bispecific SGSGSGTDFTrLKISRVEAEDVGVYYCSQSSIYPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG 47 CD3HL G-7HL molecule a SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYA)SVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYI SYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLI GGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 471 BCMA-48 BC 7A4 96- V D1a YI G2-E7 VHD1 a DYN 472 BMA-48 BC 7A4 96 472 _BCMA-48 G2-E7 VH COR2 aa WIYFASGNSEYNEKFTG 473 BCMA-48 BC 7A4 96 _______G2-E7 VH CDR3 aa LYDYDWYFDV 474 BCMA-48 BC 7A4 96- LCR a KSLVNGTH _______G2-F7 ILDR IaKSSVSGTL 475 BCMA-48 BC 7A4 96 G2-E7 VLCDR2 aa KVSNRFS 476 BCMA-48 BC 7A4 96 G2-E7 VLCDR3 aa SQSTYPEFT 477 BCMA-48 BC 7A4 96- VH QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR G2-E7 VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 478 BCMA-48 BC 7A4 96- VL aa DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF G2-E7 SGSGSGTDFTLKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR 479 BCMA-48 BC 7A4 96- VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS G2-E7 DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNEKFTGR VTMTRDTSSSTAYMELSSLRSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS DIVMTQTPLSLSVSLGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 480 BCMA-48 HL xG2-E7 HL bispecific SGSGSGTDFrLKISRVEAEDVGVYYCSQSTYPEFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 481 BCMA-49 BC 7A497 VHCDR1 aa DYYIN A3-A12 V DIa YI 482 BCMA-49 BC A4 97 VH CDR2 aa WIYFASGNSEYNQKFTG 483 BCMA-49 CA497- VH CDR3 aa LYDYDWYFDV 484 BCMA-49 BC 7A4 97- V CDR1 aa KSSQSLVHSNGNTYLH _________A3-A12 VCR aKSSVSCTL 485 BCMA49 CA497- VL CDR2 aa KVSNRFS 46 BCMA-49 BCA49- LDRAa QSTAW BC 7A4 97 486 BCMA-49 A3-A12 VHCDR3 aa SQSSTAPWT 487 BCMA-49 7A4 A1 VH BB QVQLVQSGAEVK(KPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 488 BCMA-49 BC 7A4 97- DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF A3-A12 V as SGSGSGTDFTLKISRVEAEDVGIYYCSQSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 489 BCMA-49 BC 7A4 97- VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS A3-A12 DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGIYYCSQSSTAPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGOGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 7A4 97- DIVMTQTPLSLSVTPGQPAS I SCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 490 BCMA-49 HL x A3-A12 HL bispecific SGSGSGTDFTLKISRVEAEDVGIYYCSQSSTAPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTnISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 491 BCMA-50 BC 7A4 97- VH CDR1 aa DYYIN A3-D7 VCD1a DYI 492 BMA-50 BC 7A4 97 492 BCMA-50 BC 47 VH CDR2 aa WIYFASGNSEYNQKFTG 493 BCMA-50 BC A497- VHCDR3 aa LYDYDWYFDV 494 BCMA-50 BC 7A4 97- VL CDR1 aa KSSQSLVHSNGNTYLH A3-D7 495 BCMA-50 BC 4 7- VL CDR2 aa KVSNRFS 496 BCMA-50 BC 4 VL CDR AS-C7 VLR3 as SQSSIYPWT 497 BCMA-50 BC 7A4 97- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR A3-D7 VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 498 BCMA-50 BC 7A4 97- V aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF AS-D7 SGSGSGTDFTLKISRVEAEDVGIYYCSQSSIYPWTFGQGTKLEIK 499 BMA-50 BC 7A4 97 499 BCMA-50 BAD7 scFv aI QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQCTMVTVSSGGGGSGGGGSGGGGS DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGIYYCSQSS IYPWTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS BC 7A4 97- DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF 500 BCMA-50 HL x A3-D7 HL bispecific GSGSGTDFTLKISRVEAEDVGIYYCSQSSIYPWTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG CD3 HL x CD3 HL molecule SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTuISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 501 BCMA-51 BC7A497- VHCDR1 aa DYYIN A3- E7 502 BCMA-51 BC7A497- VHCDR2 aa WIYFASGNSEYNQKFTG 503 BCMA-51 BC 7A4 97- VH CDR3 aa LYDYDWYFDV A3-E7 504 BCMA-51 BC 7A4 97- VLCDR1 aa KSSQSLVHSNGNTYLH A3-E7 VLCD 505 BCMA-51 BC 7A4 97- VLCDR2 aa KVSNRFS A3-E7 VLD2 a KSNS 506 BCMA-51 BCA497- VLCDR3 aa SQSTYPEFT 507 BCMA-51 BC 7A4 97- VH aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR A3-E7 VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSS 508 BCMA-51 BC 7A497- VL aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF A3-E7 SGSGSGTDFTLKISRVEAEDVGIYYCSQSTYPEFTFGQGTKLEIK QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRQAPGQGLEWMGWIYFASGNSEYNQKFTGR 509 BCMA-51 BC 7A4 97- VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS A3-E7 sCFv aa DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGIYYCSQSTYPEFTFGQGTKLEIK BC 7A4 97 510 BCMA-1 HL x A3-E7 HL bispecific aa QVQLVQSGAEVKKPGASVKVSCKASGYSFPDYYINWVRAPGQGLEWMGWIYFASGNSEYNQKFTGR CD3 HL x CD3 HL molecule VTMTRDTSINTAYMELSSLTSEDTAVYFCASLYDYDWYFDVWGQGTMVTVSSGGGGSGGGGSGGGGS DIVMTQTPLSLSVTPGQPASISCKSSQSLVHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRF SGSGSGTDFTLKISRVEAEDVGIYYCSQSTYPEFTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGG SLKLSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYL QMNNLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSL TVSPGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTL SGVQPEDEAEYYCVLWYSNRWVFGGGTKLTVL 511 BCMA-52 i lF8 1 VH CDR1 aa NAWMD 512 BMA-5 BC li 19 F12 BCMA-52 iIE1-F VH CDR2 aa QITAKSNNYATYYAEPVKG 613 BCMA-52 BC Eli 19- VH CDR3 aa DGYH Fi1-F8 614 BCMA-52 BC Eli 19- VL CDR1 aa RASEDIRNGLA __________F11-F8 515 BCMA-52 BC El1 19- V CDR2 aa NANSLHT _________F1i-FB LD2B8ASH 516 BCMA-52 BC El1 19- VLCDR3 aa EDTSKYPYT F11-F81 517 BCMA-52 BC E1l 19- VH aa EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAEPVK F11-F8 GRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTDDGYHWGQGTLVTVSS 518 BCMA-52 BC Eli 19- VL aa AIQMTQSPSSLSASVGETVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGS F11-F8 GTEFTLKISSLQPEDEATYYCEDTSKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAEPVK 519 BCMA-52 BCE11 scFv aa GRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM F11-F8 TQSPSSLSASVGETVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTEF TLKISSLQPEDEATYYCEDTSKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAEPVK GRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM BCMA-52 HLx BC Eli11 bispeci c TQSPSSLSASVGETVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTEF 20 CD3 HL F11-F8HL molecule a TLKISSLQPEDEATYYCEDTSKYPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAAS x CD3 HL GFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTED TAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVT

LTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEA

EYYCVLWYSNRWVFGGGTKLTVL 521 BCMA-53 BC Eli 19V G3-FB VH CDR1 aa NAWI4D 522 BCM-53 BC Eli 19 522 BCMA-53 B 1G3-F VHCDR2 aa QITAKSNNYATYYAAPVKG 523 BCMA-53 BC Ei1 VH CDR3 aa DGYH 524 BCM-53 BC Eli 19 524 BCMA-53 BCE11 VLCDR1 aa RASEDIRNGLA 525 BCMA-53 BC Eli 19- VLCDR2 aa NANSLHS G3-FB ____ 526 BCMA-53 BC El1 VL CDR3 aa EDTSKYPYT 527 BCMA-53 BC Eli 19- VH aa EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK G3-F8 GRETISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSS 528 BCMA-53 BC El1 19- VL aa AIQMTQSPSSLSASVGDRVTIKCRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHSGVPSRFSGSGS G3-F8 GTDFTLTISSMQPEDEGTYYCEDTSKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK 529 BCMA-53 BC Eli sc9 v GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM G3-F8 scFv TQSPSSLSASVGDRVTIKCRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHSGVPSRFSGSGSGTDF TLTISSMQPEDEGTYYCEDTSKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM BC El11- TQSPSSLSASVGDRVTIKCRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHSGVPSRFSGSGSGTDF 530 BCMA-53 HL1x G 0F -L bispecdfic TLTISSMQPEDEGTYYCEDTSKYPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAAS 63 CMA3 HL xG 8H aa CD3HL xCD3 HL molecule GFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTED TAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVT LTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEA EYYCVLWYSNRWVFGGGTKLTVL 531 BCMA-54 BCEll 19- VHCDR aa NAWMD 532 BCMA-54 BCE1119-VK 532 BCM-54 2-F19 VH CDR2 aa QITAKSNNYATYYAAPVKG 533 BCMA-54 BC Eli 19 B2-FB VH CDR3 82 DGYH 534 BCMA-54 BC El1 19- VLCDRi 82 RASEDIRNGLA BC Eli1 19 535 BCMA-54 82-PB VL CDR2 aa NANSLHT 536 BCMA-54 BC Eli 19- V CDR3 aa EDTSKYPYT 82-PB VCRF2 DSYY 637 BCMA-54 BC El1 19- VH aa EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK B2-F8 GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSS 538 BCMA-54 BC Eli 19- VL aa AIQMTQSPSSLSASVGDRVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGS B2-FB GTDFTLTISSLQPEDEAIYYCEDTSKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK 539 BCMA-54 BC Eli 19- scFv aa GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM 82-F8 TQSPSSLSASVGDRVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTDF TLTISSLQPEDEAIYYCEDTSKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM BCE1119- TQSPSSLSASVGDRVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTDF 640 BCMA-54 HL x B2-F8 HL bispecific TLTISSLQPEDEAIYYCEDTSKYPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAAS CD3HL x CD3 HL molecule GFT FNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTED TAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVT LTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEA _EYYCVLWYSNRWVFGGGTKLTVL 541 BCMA-55 BC E11-20- VH CDR1 aa NAWMD ____ H9-E9 542 BCMA-55 BC E11-20- VH CDR2 aa QITAKSNNYATYYAAPVKG ____ H9-E9 543 BCMA-55 BC E 11-2- VH CDR3 aa DGYH ___H9-E9 HCR a DY 544 BCMA-55 BC E11-20- VL CDR1 aa RASEDIRNGLA BM55 H9-E9 I 1 1 545 BCMA-55 BC E11-20- V CDR2 aa NANSLHT H9-E9 V D22 ASH 546 BCMA-55 BC El1-20- VLCDR3 aa EETLKYPYT H9-E9 L 547 BCMA-55 BC E11-20- VH aa EVQLVESGGSLVKPGGSLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAAPVK H9-E9 GRFTISRDDSKNTLYLQMNSLKEEDTAVYYCTDDGYHWGQGTLVTVSS 548 BCMA-55 BC E11-20- V aa AIQMTQSPSSLSASVGDRVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGS HS-E9 GTDFTLTISNLQPEDEATYYCEETLKYPYTFGQGTKLEIK EVQLVESGGSLVKPGGSLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAAPVK 549 BCMA-55 BC E11-20- scFv aa GRFTISRDDSKNTLYLQMNSLKEEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM H9-E9 TQSPSSLSASVGDRVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTDF TLTISNLQPEDEATYYCEETLKYPYTFGQGTKLEIK EVQLVESGGSLVKPGGSLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAAVK GRFTISRDDSKNTLYLQMNSLKEEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM TQSPSSLSASVGDRVT IACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTDF 50EBCMA-55 HL x H9-EHL bispecific TLTISNLQPEDEATYYCEETLKYPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAAS CD3HL x CD3 HL molecule GFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFrISRDDSKNTAYLQMNNLKTED TAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVT LTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEA EYYCVLWYSNRWVFGGGTKLTVL 551 BCMA-56 11-E9- VH CDRi aa NAWMD 552 BCMA-56 E11-19- VH CDR2 aa QITAKSNNYATYYAEPVKG 553 BCMA-56 BC E11-19- VH CDR3 aa DGYH 554 BCMA-56 BC El1-19- VLCDR1 aa RASEDIRNGLA __________Fli-E9 555 BCMA-56 E1-iS- VL CDR2 aa NANSLHT BC Eli-iS 556 BCMA-56 F11-9- VL CDR3 aa EETLKYPYT 557 BC E11-19- EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAEPVK BCMA-56 F11-E9 VH 88 GRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTDDGYHWGQGTLVTVSS BCMA-56 BC Eli-19- V aa AIQMTQSPSSLSASVGETVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGS 55 8 BM5 F1i-E9 GTEFTLKISSLQPEDEATYYCEETLKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAEPVK BC Eli-19- GRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM 559 BCMA-56 F11-E9 scFv aa TQSPSSLSASVGETVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTEF TLKISSLQPEDEATYYCEETLKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWVAQITAKSNNYATYYAEPVK GRFTISRDDSKNTLYLQMNSLKTEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM BC E11-19- TQSPSSLSASVGETVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTEF 560 BCMA-56 HL x F11-E9 HL bispecific TLKISSLQPEDEATYYCEETLKYPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAAS CD3HL x CD3 HL molecule GFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMNNLKTED TAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVT LTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEA EYYCVLWYSNRWVFGGGTKLTVL 561 BCMA-57 BC E 1-19- VH CDR1 aa NAWMD 562 BCMA-57 BC Eli-19 62-E9 VH CDR2 aa QITAKSNNYATYYAAPVKG 563 BCMA-57 E 1-19- VH CDR3 aa DGYH 564 BCMA-57 BC El 1-19- VL CDR1 aa RASEDIRNGLA B2- E9 11 565 BCMA-57 BC El 1-19- VL CDR2 aa NANSLHT B2-E9 _________________________________________ 566 BMA-57 BC El1-19 566 BCMA-579 VL CDR3 aa EETLKYPYT 567 BCMA-57 BC E11-19- VH aa EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK B2-E9 GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSS 568 BCMA-57 BC E11-19- VL a AIQMTQSPSSLSASVGDRVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGS B2-E9 GTDFTLTISSLQPEDEAIYYCEETLKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK B69 BCMA-57 C E11-19- scFv aa GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM B2-E9 TQSPSSLSASVGDRVTIACRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTDF

TLTISSLQPEDEAIYYCEETLKYPYTFGQGTKLEIK

EVQLVESGGGLVKPGESLRLSCAASGETFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM TQSPSSLSASVGDRVTIACRASEDI RNGLAWYQQKPGKAPKLLIYNANSLHTGVPSRFSGSGSGTDF 0 CM HL 8TLTISSLQPEDEAIYYCEETLKYPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAAS CD3 HL x CD3 HL molecule GFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTED TAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVT LTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEA EYYCVLWYSNRWVFGGGTKLTVL 571 BCMA-58 BC El1-19- VH CDR1 aa NAWMD G3-E9 VHR18 NAD 572 BCMA-58 BC 1-19- VH CDR2 aa QITAKSNNYATYYAAPVKG 573 BCMA-58 BC Eli-19- VH CDR3 aa DGYH G3-ES 574 BCMA-58 BC 1-19- VL CDR1 aa RASEDIRNGLA 575 BCMA-58 BC El-19- VL CDR2 aa NANSLHS G3-ES LD28 ASH 576 BCMA-58 BC 1-19. VL CDR3 aa EETLKYPYT 577 BCMA-58 BC E1i-19- VH aa EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK G3-E9 GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSS 578 BCMA-58 BC El1-19- VL aa AIQMTQSPSSLSASVGDRVTIKCRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHSGVPSRFSGSGS GS-E9 GTDFTLTISSMQPEDEGTYYCEETLKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK 579 BCMA-58 BC Eli-19- GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM GI-E9 sFv TQSPSSLSASVGDRVTIKCRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHSGVPSRFSGSGSGTDF TLTISSMQPEDEGTYYCEETLKYPYTFGQGTKLEIK EVQLVESGGGLVKPGESLRLSCAASGFTFSNAWMDWVRQAPGKRLEWIAQITAKSNNYATYYAAPVK BCMA-58 HL x BC E1L-19- bispecific GRFTISRDDSKNTLYLQMNSLKKEDTAVYYCTDDGYHWGQGTLVTVSSGGGGSGGGGSGGGGSAIQM 580 CD3 HL G3-E9 HL molecule aa TQSPSSLSASVGDRVTIKCRASEDIRNGLAWYQQKPGKAPKLLIYNANSLHSGVPSRFSGSGSGTDF x CD3 HL TLTISSMQPEDEGTYYCEETLKYPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLKLSCAAS

GFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMNNLKTED

TAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVSPGGTVT LTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGVQPEDEA EYYCVLWYSNRWVFGGGTKLTVL 581 BCMA-59 VH CDR1 aa NYDMA 582 BCMA-59 BC 5G9- VH CDR2 aa SIITSGGDNYYRDSVKG ____ ~91-D2 ____ 583 BCMA-59 VHCDR3 aa HDYYDGSYGFAY 584 BCMA-59 VL CDR1 aa KASQSVGINVD ___ 91D2 VL 585 BCMA-59 BC DG9- VLCDR2 aa GASNRHT 91 -D2 586 BCMA-59 BD VL CDR3 aa LQYGSIPFT 587 BCMA-59 BC 5G9- VH QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 91-D2 aa FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 588 BC 5G9- EIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS 91-D2 VL 00 GTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 589 BCMA-59 BC 5G9- FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG 91-D2 scFv aa GSEIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BCSG9- GSEIVMTQSPASMSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGI PARFSGS 590 BCMA-59 HL x 91-D2 HL bispecific a GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 591 BCMA-60 9C ~ VH CDR1 aa NYDMA 91-C7 592 BCMA-60 BC5G9- VH CDR2 aa SIITSGGDNYYRDSVKG 593 BCMA-60 BC 1- VH CDR3 aa HDYYDGSYGFAY 594 BCMA-60 9-C VL CDR1 aa KASQSVGINVD 595 BCMA-60 BC 5G9 91-C7 VL CDR2 aa GASNRHT 596 BCMA-60 BC5 G9- VLCDR3 aa LQYGSIPFT 91-C7 597 BCMA-60 BC 5G9- VH aa QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 91-C7 FTISRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 598 BCMA-60 BC 5G9- V aa EIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS 91-C7 GREFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 599 BCMA-60 BC 5G9- scFv aa FTISRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG 91-C7 GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGREFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR FTISRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 5G9- GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS 600 BCMA-60 HL x 91-C7 HL bispecific GSGREFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPECEAEYYCVLWYSNRWVFGGGTKLTVL 601 BCMA-61 BC 5G9- VH CDR1 aa NYDMA ___________91 -E4 ____ 602 BMA-61 BC 5G9 602 BCMA-61 91-E4 VH CDR2 aa SIITSGGDNYYRDSVKG 603 BCMA-61 BC5G9- VH CDR3 aa HDYYDGSYGFAY 604 BCMA-61 VL CDR1 aa KASQSVGINVD 605 BCMA-61 BC 5G9- VLCDR2 aa GASNRHT 91-E4 VLD2 a GART 606 BCMA-61 BC 5G9 91-E4 VLCDR3 aa LQYGSIPPr 607 BCMA-61 BC 5G9- VH aa QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 91-E4 FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS 608 BCMA-61 BC 5G9- V aa EIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS 91-E4 GTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFrFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 609 BCMA-61 BC SG9- scFv aa FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG 60 -E4 91-E4 GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR FTISRDNSKNTLYLQMNSLRSEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 5G9- GSEIVMTQSPATLSVSPGERVTLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGI PARFSGS 610 BCMA-61 HL x 91-E4 HL bispecific GSGTEFTLTISSLQSEDFAVYYCLQYGSIPFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL xCD3HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 611 BCMA-62 BC VH CDR1 aa NYDMA 612 BCMA-62 BC 5G9 VH CDR2 aa SIITSGGDNYYRDSVKG 92-ElO 613 BCMA-62 BG2-E1 VH CDR3 aa HDYYDGSYGFAY 614 BCMA-62 B2-E109 VLCDR1 aa KASQSVGINVD BC 5GB 616 BCMA-62 92-El0~ VL CDR2 aa GASNRHT 616 BMA-62 BC 5GB 616 BCMA-62 92-E10~ VL CDR3 aa LQYGSIPFT 617 BCMA-62 BC G - VH aa QVQLVESGGGVVQPGRSLRLSCAASGFrFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 92-ElO FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSS BCMA2 BC 5G9- EIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGSGS 618 BCMA-6 92-E10 VL 8 GTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR 619 BCMA-62 BC 5G9- sv FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG 92-ElO scFv GSEIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS GSGTEFTLTISSLQAEDFAVYYCLQYGSIPFTFGPGTKVDIK QVQLVESGGGVVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVASIITSGGDNYYRDSVKGR FTVSRDNSKNTLYLQMNSLRAEDTAVYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGSGGG GSEIVMTQSPATLSVSPGERATLSCKASQSVGINVDWYQQKPGQAPRLLIYGASNRHTGIPARFSGS BCMA-62 HL x G9- bispecific GSGTEFTLTISSLQAEDFAVYYCLQYGSI PFTFGPGTKVDIKSGGGGSEVQLVESGGGLVQPGGSLK 620 CD3 HL 92-E10HHL molecule aa LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 621 BCMA-63 7VH CDR1 8 NYDMA 622 BCMA-63 BC 3A4-37- VH CDR2 aa SISTRGDITSYRDSVKG CS 623 BCMA-63 BC 3A4-37- VH CDR3 aa QDYYTDYMGFAY 624 BCMA-63 3A4-37- VLCDR1 aa RASEDIYNGLA C8 625 BCMA-63 C3A4-37- VL CDR2 aa GASSLQD 626 BCMA-63 C3A4-37- VL CDR3 aa QQSYKYPLT 627 BCMA-63 BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR C8 FTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 628 BCMA-63 BC 3A4-37- VL aa AIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS C8 GTDYTLTISSLQPEDEATYYCQQSYKYPLTFGGGTKVEIK BC 3A4-37 629 BCMA-63 C8 3 scFv aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FT ISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG GSAIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTDYTLTISSLQPEDEATYYCQQSYKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG GSAIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 630 BCMA-63 HL x BC 4-37- bispecific GSGTDYTLTISSLQPEDEATYYCQQSYKYPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN - NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 631 BMA-64 BC 3A4-37 631 BCMA-64 VH CDR1 aa NYDMA 632 BCMA-64 BC3A4-37- VH CDR2 aa SISTRGDITSYRDSVKG 633 BCMA-64 BC 3A4-37- VH CDR3 aa QDYYTDYMGFAY 634 BCMA-64 BC3A4-37- VL CDR1 aa RASEDIYNGLA 635 BCMA-64 BC 3A4-37- VL CDR2 aa GASSLOD 636 BCMA-64 BC3A4-37- VL CDR3 aa QQSYKYPLT 637 BCMA-64 BC 3A4-37- VH aa EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR C9 FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 638 BCMA-64 BC 3A4-37- VL aa AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS C9 GTDFTLTISSMQPEDEATYYCQQSYKYPLTFGGGTKVEIK EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 639 BCMA-64 BC 3A4-37- sc~v as FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGSGGGGSGGG C9 CM-v CS GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTDFTLTISSMQPEDEATYYCQQSYKYPLTFGGGTKVEIK BC 3A4-37 640 BCMA-64 HL x C9HL bispecific aa EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR CD3HL x CD3 HL molecule FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTDFTLTISSMQPEDEATYYCQQSYKYPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 641 BCMA-65 BC 3A4-37- VHCDR1 as NYDMA Eli HCR a YM 642 BCMA-65 3A4-37- VH CDR2 as SISTRGDITSYRDSVKG 643 BCMA-65 BC 3A4-37- VH CDR3 as QDYYTDYMGFAY Eli 644 BCMA-65 BC 3A4-37- VLCDR1 as RASEDIYNGLA Eli LC~ s AEINL 645 BCMA-65 BC3A4-37- VLCDR2 as GASSLQD Eli 646 BCMA-65 BC 3A4-37- VL CDR3 as QQSYKYPLT Eli 647 BCMA-65 BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR Eli FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 648 BCMA-65 BC 3A4-37- VL as AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS Eli GTHYTLTISSLQPEDEATYYCQQSYKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 649 BCMA-65 BC 3A4-37- scFv aa FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG El1 GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYOOKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTHYTLTISSLQPEDEATYYCQQSYKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG BCMA-65 HLx BC 3A4-37- bispecific GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 650 CD3 HL El molecule a GSGTHYTLTISSLQPEDEATYYCQQSYKYPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK x CD3 HL LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS

PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV

QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 651 BCMA-66 BC 3A4-37- VH CDR1 aa NYDMA CB-G1 ____________________________ 652 BCMA-66 BC 4-37- VH CDR2 aa SISTRGDITSYRDSVKG 653 BCMA-66 BC 4-37- VH COR3 aa QDYYTDYMGFAY 654 BCMA-66 BC 3A4-37- VL CDR1 aa RASEDIYNGLA C8-G1 655 BCMA-66 BC 4-37- VL CDR2 aa GASSLQD 656 BCMA-66 BC 3A4-37- VLCDR3 aa AGPHKYPLT C8-G 1 LCR a GHYL 657 BCMA-66 BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR C8-G1 FTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 658 BCMA-66 BC 3A4-37- VL aa AIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS C8-G1 GTDYTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 659 BCMA-66 BC 3A4-37- FTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG C8-G1 scFv aa GSAIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTDYTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG 3A4-37- GSAIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 660 BCMA-66 HL x BC G- bispecific GSGTDYTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HDLH x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 661 BCMA-67 BC3A4-37- VHCDR1 aa NYDMA 662 BCMA-67 BC3A4-37- VH CDR2 aa SISTRGDITSYRDSVKG Ell-Gi __________________________________ 663 BCMA-67 3A-37- VH CDR3 aa QDYYTDYMGFAY 664 BCMA-67 3A4-37- VL CDR1 aa RASEDIYNGLA 665 BCMA-67 BC 3A4-37- VL CDR2 aa GASSLQD ____ _________Ell-GI ____ 666 BCMA-67 BC3A4-37- VLCDR3 aa AGPHKYPLT Eli -Gi 1 667 BCMA-67 BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR El1-GI FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS BC 3A4-37- V AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLODGVPSRFSGSGS El1-G 1 L aa GTHYTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 669 BCMA-67 BC 3A4-37- FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG El1-Gl scFv a GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTHYTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 3A4-37- GSAIQMTQSPSSLSASVGDRVT ITCRASEDI YNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 670 BCMA-67 HL x El-Gi HL bispecific _ GSGTHYTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 671 BCMA-68 BC 3A4-37- VH CDR1 aa NYDMA 672 BCMA-68 BC 3A4-37- VH CDR2 aa SISTRGDITSYRDSVKG C8- G8 673 BCMA-68 BC 3A4-37- VH CDR3 aa QDYYTDYMGFAY 674 BCMA-68 BC 3A4-37- VL CDR1 aa RASEDIYNGLA C8-3G 7 65 BCMA-6B BC 3A4-37- VCR a GSSQ 661C8- G8 ______________________________________ 676 BCMA-68 BC 3A4-37- VL CDR3 aa QQSRNYQQT 677 BCMA-68 BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR C8-G8 FTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 678 BCMA-68 BC 3A4-37- V aa AIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS C8-G8 GTDYTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 679 BCMA-68 BC 3A4-37- sFTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG C8-GB scFv aa GSAIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTDYTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSS ISTRGDITSYRDSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 3A4-37- GSAIQMTQSPSSLSASVGDTVTITCRASEDIYNGLAWYQQKPGKAPKLLI YGASSLQDGVPSRFSGS 680 BCMA-68 HL x C-G8 HL bispecific aa GSGTDYTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 681 BCMA-69 BC 3A-37- VH COR1 aa NYDMA Eli-GB 682 BCMA-69 C3A37- VH CDR2 aa SISTRGDITSYRDSVKG 683 BCMA-69 C3A37- VH CDR3 aa QDYYTDYMGFAY El 1-GB 684 BMA-69 BC 3A4-37 684 BCMA-69 3E7l-G VL CDR1 aa RASEDIYNGLA BC 3A4-37- DR2 a8 GASSLQD 686 BCMA-69 3A -37- V CDR3 aa QQSRNYQQT BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 687 BCMA-69 El1-G8 FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 688 BCMA-69 BC 3A4-37- VL 88 AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS Eli-G8 GTHYTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSTSTRGDITSYRDSVKGR 689 BCMA-69 BC 3A4-37- FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG El-G8 GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTHYTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 3A4-37- GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 690 BCMA-69 HL x 1G HL bispecific GSGTHYTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 691 BCMA-70 BC VH CDR1 aa NYDMA All1-G8 HD1a YM 692 BCMA-7 3A437- VH CDR2 aa SISTRGDITSYRDSVKG 693 BCMA-70 BC 3A4-37 All -GB VH CDR3 as QDYYTDYMGFAY 694 BCMA-70 BC 3A4-37- VLCDR1 aa RASEDIYNGLA AllI-GB VD1 1aRSDINL 695 BCMA-70 BC 3A4-37- VL CDR2 aa GASSLQD AllI-GB 696 BCMA-70 BC 3A4-37 All-GB VLCDR3 as QQSRNYQQT 697 BCMA-70 BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR All-G8 FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 698 BCMA-70 BC 3A4-37- VL aa AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS Ali-G8 GTEFTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 699 BCMA-70 BC 3A4-37- FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG All-G8 scFv as GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS

GSGTEFTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIK

EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 3A4-37- GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 700 BCMA-70 HL x A11-G8 HL bispecific GSGTEFTLTISSLQPEDEATYYCQQSRNYQQTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 701 BCMA-71 BC 3A4-37- VH CDR1 aa NYDMA All-Gi VHD1a NYM 702 BCMA-71 3A4-37- VH CDR2 aa SISTRGDITSYRDSVKG 703 BMA-7l BC 3A4-37 703 BCMA-71 All-GI VH CDR3 aa QDYYTDYMGFAY 704 BCMA-71 BC 3A4-37- VL CDR1 aa RASEDIYNGLA Al l-Gl _______________________________ 705 BCMA-71 A3A-37- VL CDR2 aa GASSLOD 706 BCMA-71 BC 3A4-37- VL CDR3 as AGPHKYPLT All-GI _____ ___________________________________________ 707 BCMA-71 BC 3A4-37- VH aa EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR Al-G1 FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 708 BCMA-71 BC 3A4-37- VL aa AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS Al-G1 GTEFTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 709 BCMA-71 BC 3A4-37- FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG Al-G1 scFv a GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTEFTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGGSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR BC3A4-37- FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG 710 CD3 HL mA-G1 HL molecule aa GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS xCD3 HL GSGTEFTLTISSLQPEDEATYYCAGPHKYPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK

LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN

NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 711 BCMA-72 BC 3A4-37- VH CDR1 as NYDMA C9-G1 712 BCMA-72 BC 3A4-37- VH CDR2 aa SISTRGDITSYRDSVKG ____ C9-Gl 713 BCMA-72 BC 4-37- VH CDR3 as QDYYTDYMGFAY 714 BCMA-72 BC 3A4-37- VL CDR1 aa RASEDIYNGLA 715 BCMA-72 BC 3A4-37- VL CDR2 as GASSLQD 716 BCMA-72 BC 3A4-37- VLCDR3 as AGPHKYPLT 717 BCMA-72 BC 3A4-37- VH aa EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR C9-G1 FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 718 BCMA-72 BC 3A4-37- VL as AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS CS-G1 GTDFTLTISSMQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 719 BCMA-72 BC 3A4-37- FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG CS-G1 scFv aa GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTDFTLTISSMQPEDEATYYCAGPHKYPLTFGGGTKVEIK EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 3A4-37 GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 720 BCMA-72 HL x C9-G1 HL bispecific GSGTDFTLTISSMQPEDEATYYCAGPHKYPLTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 721 BCMA-73 BC A4-37- VH CDR1 aa NYDMA C9-G8 _______________________________ 722 BCMA-73 BC A4-37- VH CDR2 aa SISTRGDITSYRDSVKG 723 BMA-73 BC 3A4-37 723 BCMA-73 C-37 VH CDR3 aa QDYYTDYMGFAY 724 BCMA-73 BC A4-37- VLCDR1 aa RASEDIYNGLA 725 BCMA-73 BC 3A4-37- VLCDR2 as GASSLQD ____ ________CS-Ge 726 BCMA-73 BC 3A4-37- VL CDR3 aa QQSRNYQQT CS-GB 727 BCMA-73 BC 3A4-37- VH aa EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR CS-G8 FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSS 728 BCMA-73 BC 3A4-37- VL aa AIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGSGS CS-G8 GTDFTLTISSMQPEDEATYYCQQSRNYQQTFGGGTKVEIK EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR 729 BCMA-73 BC3A4-37- sc~v as FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG CS-G8 GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS GSGTDFTLTISSMQPEDEATYYCQQSRNYQQTFGGGTKVEIK EVQLLESGGGLVQPGRSLRLSCAASGFTFSNYDMAWVRQAPGKGLEWVSSISTRGDITSYRDSVKGR FTISRDNSKNTLYLQMNSLRAEDTAVYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGGG BC 3A4-37- GSAIQMTQSPSSLSASVGDRVTITCRASEDIYNGLAWYQQKPGKAPKLLIYGASSLQDGVPSRFSGS 730 BCMA-73 HL x C9-G8 HL bispecific GSGTDFTLTISSMQPEDEATYYCQQSRNYQQTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 731 BCMA-74 BC C3-33- VH CDRI as NFDMA 731 BCM-74 D7-13 732 BCMA-74 BC3-33- VH CDR2 aa SITTGGGDTYYADSVKG 732 BCMA-74 BC7-3 B C3-33- VH CDR3 as HGYYDGYHLFDY 734 BCMA-74 B C3-33- VLCDR1 aa RASQGISNYLN 735 BCMA-74 BC C3-33- VLCDR2 aa YTSNLQS D7-B1 LCR a TNQ 736 BCMA-74 BC C3-33- R3 as MGQTISSYT DBi VLCDR3a GTSY 737 BCMA-74 BC C3-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR D7-B1 FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 738 BCMA-74 BC C3-33- VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS D7-B1 GTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 739 BCMA-74 BC C3-33- aa FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG D7-B1 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC C3-33- GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 740 BCMA-74 HL x D7-B1 HL bispecific GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 741 BCMA-75 BC C13-33- VH CDR1 aa NFDMA F8-B1 ________ 742 BCMA-75 BC B3-33- VH CDR2 aa SITTGGGDTYYADSVKG 743 BCMA-75 BC B3-33- VH CDR3 as HGYYDGYHLFDY 744 BCMA-75 BC C3-33- VLCDR1 aa RASQGISNYLN 745 BCMA-75 BC C3-33- VL CDR2 aa YTSNLQS 746 BCMA-75 BCB13-33- VLCDR3 aa MGQTISSYT F8-B1 746 BCMA-75 BC C3-33 747 BCMA5 F8-B VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 748 BCMA-75 BC C3-33- VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS F8-B1 GTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 749 BCMA-75 BC C3-33- FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG F7B1- scv aa GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGOGTLVTVSSGGGGSGGGGSGGG BC C3-33- GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 750 BCMA-75 HL x F8-1 HL bispecific GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 761 BCMA-76 BC C3-33- VH CDR1 aa NFDMA 752 BCMA-76 B13-33- VH CDR2 aa SITTGGGDTYYADSVKG 753 BCMA-76 BC C3-33- VH CDR3 aa HGYYDGYHLFDY 764 BCMA-76 BCC3-33- VLCDR1 aa RASQGISNYLN P9-Bi ____ 755 BCMA-76 BC C3-33- VL CDR2 aa YTSNLQS F9-131 ____ 756 BCMA-76 BC C3-33- VLCDR3 aa MGQTISSYT P9-El DR aMGTSY 757 BCMA-76 BC C3-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR F9-V1 FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 758 BCMA-76 BC C3-33- VL aa DIQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS F9-B GTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK BC C3-33 759 BCMA-76 F9-B1 scFV aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSS ITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTISCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 760 BCMA-76 HL x CB1 HB bispecific a GSGTDYTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 761 BCMA-77 BC C3-33- VH CDR1 aa NFDMA 762 BCMA-77 C 33- VH CDR2 aa SITTGGGDTYYADSVKG 763 BCMA-77 BC C3-33- VH CDR3 aa HGYYDGYHLFDY 764 BCMA-77 BC C3-33- VL CDR1 aa RASQGISNYLN F 1011 766 BCMA-77 BC C3-33- VL CDR2 aa YTSNLQS FlOBi 766 BCMA-77 FC33- VL CDR3 aa MGQTISSYT 767 BCMA-77 BC C3-33- VH aa EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR F10B1 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 768 BCMA-77 BC C3-33- VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS F10B1 GTDFTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR 769 BCMA-77 BC C3-33- scFv aa FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG 769 B F0B1 GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCMGQTISSYTFGQGTKLEIK 770 BCMA-77 HLx BC C3-33- bispecific a EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR CD3 H L x CD3 H L molecule FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG x CD3 H GSDIQMTQSPSSLSASVGDRVTITCRASQGISNYLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDFTLTISSLOPEDFATYYCMGQTISSYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 771 BCMA-78 Al -Al 0 VH CDR1 aa NFDMA 772 BCMA-78 1 A VH CDR2 aa SITTGGGDTYYADSVKG A-AIO VH 773 BCMA-78 BC EA-33- VH CDR3 aa HGYYDGYHLFDY All -AlO 774 BCMA-78 BC E5-33- VLCDR1 aa RASQGISNHLN All-AlO VC 775 BCMA-78 BC EA33- VL CDR2 aa YTSNLQS ____ All-A1O 1______________________________________ 776 BCMA-78 BC E-33- VLCDR3 aa QQYFDRPYT All-AlO LC 777 BCMA-78 BC E5-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR All-A10 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 778 BCMA-78 BC E5-33- VL aa DIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWFQQKPGRAPKPLIYYTSNLQSGVPSRFSGSGS All-A10 GTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGPrFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 779 BCMA-78 BC E5-33- FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG All-A10 scFv aa GSDIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWFQQKPGRAPKPLIYYTSNLOSGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR BC E5-33- FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BCMA-78 HL x All-A10 bispecific GSDIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWFQQKPGRAPKPLIYYTSNLQSGVPSRFSGS 780 CD3HL HLx CD3 molecule aa GSGTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK HL LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS

PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV

QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 781 BCMA-79 BC VH CDR1 aa NFDMA 782 BCMA-79 BC E-33- VH CDR2 aa SITTGGGDTYYADSVKG ___ ________ 81-AiD VH 783 BCMA-79 VH CDR3 aa HGYYDGYHLFDY Bil-AlO 784 BCMA-79 BC1 Ai0 VL CDR1 aa RASQGISNHLN 785 BCMA-79 BC E5-33 7 A-Ai- VL CDR2 aa YTSNLQS 786 BCMA-79 BC A5-33- VL CDR3 aa QQYFDRPYT 787 BCMA-79 BC E5-33- aa EVQLVESGGGLVQPGGSLRLSCAASGFrFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR Bi1-Ai0 VH FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 788 BCMA-79 BC E5-33- aa DIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS B11-AiD VL GTDYTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 789 BCMA-79 BC E5-33- FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG B11-Ai0 GSDIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC ES-33- GSDIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 790 BCMA-79 HL x B11-A10 bispecific GSGTDYTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL HL x CD3 mdecule LSCAASGFTFNKYAMNWVRQAPGXGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN HL NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 791 BCMA-80 1 10 VH CDR1 aa NFDMA -- A1 VHC 791~ ~ ~ B ECM-5 Gl33- __ 792 BCMB80 E-l- V DR2 aa SITTGGGDTYYADSVKG 793 BCMA-80 BC E5-33- VH CDR3 aa HGYYDGYHLFDY Gili-Al 0 7 1 -A10 VLCDRI aa RASQGISNHLN BC E5-33- R2a YTLQ 795 BCMA-8 0 VLCDR2 aa YTSNLQS ___ ______ G1_ -AlO LC 796 BCMA-80 BC E5-33- VL CDR3 aa QQYFDRPYT G -AlO VLCD 797 BCMA-80 BC E5-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR Gi1-Al FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 798 BCMA-80 BC E5-33- VL aa DIQMTQSPSSLSASVGDRVTITCRASQGISNHLNWFQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS Gi1-A10 GTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 799 BCMA-80 BC E5-33- scFv aa FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG Gil-A1O GSDIQMTQSPSSLSASVGDRVTITCRASQGISNHLNWFQQKPGKAPKPLIYYTSNLQSGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC ES-33- GSDIQMTQSPSSLSASVGDRVTITCRASQGISNHLNWFQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 800 BCMA-80 HL x G11-A1O bispecific GSGTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK 0 CD3 HL HL x CD3 molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN HL NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 801 BCMA-81 BC A1 VH CDR1 aa NFDMA G12-AlO VHDla NFA 802 BCMA-81 BC E5-33 802 G12-AO VH CDR2 aa SITTGGGDTYYADSVKG 803 BCMA-81 BC2-A VH CDR3 aa HGYYDGYHLFDY 804 BCMA-81 BC E5-33- VLCDR1 aa RASQGISNHLN G12-Alo VL CR1 Y 805 BCMA-81 BC1E-3- VLCDR2 Iaa YTSNLQS 8 2-A10 VL CDR3 aa QQYFDRPYT 807 BCMA-81 BC E5-33- VH aa EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR G12-A1O FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 808 BCMA-81 BC E5-33- V aa DIQMTQSPSSLSASVGERVTITCPASQGISNHLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGSGS G12-A1O GTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR 809 BCMA-81 BC E5-33- aa FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG G12-A1O scFv GSDIQMTQSPSSLSASVGERVTITCRASQGISNHLNWYQQKPGKAPKSLTYYTSNLQSGVPSRFSGS GSGTDFTLT ISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIK EVQLVESGGGLVQPGRSLRLSCAASGPTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC E5-33- GSDIQMTQSPSSLSASVGERVTITCRASQGISNHLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS 810 BCMA-81 HL x G12-Alo bispecific GSGTDFTLTISSLQPEDFATYYCQQYFDRPYTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL HL x CD3 molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN HL NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 811 BCMA-82 BC ES-33- VH CDR1 aa NFDMA Al1-B8 812 BCMA-82 BCE5-33- VH CDR2 aa SITTGGGDTYYADSVKG _________All-B8 813 BCMA-82 BC E5-33- VHCDR3 aa HGYYDGYHLFDY _________All-13B 814 BCMA-82 BC E5-33- VLCDR1 aa RASQGISNHLN ____ All-B8 815 BCMA-82 C 5--33- VCDR2 aa YTSNLQS 816 BCMA-82 E5-33- VLCDR3 aa QQYSNLPYT 817 BCMA-82 BC E5-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR All-B8 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 818 BCMA-82 BC E5-33- VL aa DIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWFQQKPGRAPKPLIYYTSNLQSGVPSRFSGSGS All-B8 GTDFTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 819 BCMA-82 BC E5-33- scFv aa FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG All-B8 GSDIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWFQQKPGRAPKPLIYYTSNLQSGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIK EVOLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSS ITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC ES-33- GSDIQMTQSPSSLSASVGDRVTISCRASQGI SNHLNWFQQKPGRAPKPLIYYTSNLQSGVPSRFSGS 820 BCMA-82 HL x All-B8 HL bispecific GSGTDFTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 821 BCMA-83 CES-33- VH CDR1 an NFDMA 811-8 822 BCMA-83 B 1E5-33- VH CDR2 aa SITTGGGDTYYADSVKG 823 BCMA-83 BCE5-33- VH CDR3 aa HGYYDGYHLFDY 824 BCMA-83 BE5-33- VLCDR1 aa RASQGISNHLN B_ 1 1-88 1 825 BCMA-83 BCE5-33- VL CDR2 aa YTSNLQS 826 BCMA-83 CE5-33- VLCDR3 aa QQYSNLPYT 811-8 827 BCMA-83 BC E5-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 811-B8 FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 828 BCMA-83 BC E5-33- DIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS B11-B8 VL an GTDYTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 829 BCMA-83 BC E5-33- scFv aa FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG B11-B8 GSDTQMTQSPSSLSASVGDRVTISCRASQGTSNHLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS

GSGTDYTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIK

EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTISCRASQGISNHLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGS 830 BCMA-83HLx B 5-3HL bispecific a GSGTDYTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK C H x CD3 H L molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 831 BCMA-84 BC E5-33- VH CDR1 aa NFDMA G1 2-BB 832 BCMA-84 2-33 VH CDR2 aa SITTGGGDTYYADSVKG 833 BCMA-84 25-33- VH CDR3 aa HGYYDGYHLFDY 834 BCMA-84 BCE5-33- VLCDR1 aa RASQGISNHLN 835 BCMA-84 BC E5-33- VL CDR2 aa YTSNLQS BCMA-84 G12-138 ____ 836 BCMA-84 C2F5-33- VLCDR3 as QQYSNLPYT 837 BCMA-84 BC E5-33- VH aa EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR G12-B8 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 838 BCMA-84 BC E5-33- VL aa DIQMTQSPSSLSASVGERVTITCRASQGISNHLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGSGS G12-B8 GTDFTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIK EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR 839 BCMA-84 BC E5-33- scFv FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG G12-B8 a GSDIQMTQSPSSLSASVGERVTITCRASQGISNHLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS GSGTDFTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIK EVQLVESGGGLVQPGRSLRLSCAASGFTFSNFDMAWVRQAPAKGLEWVSSITTGGGDTYYADSVKGR BCMA-84 HL x BC E5-33- bispecific FT ISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG 840 CD3 HL G12-B8 HL molecule aa GSDIQMTQSPSSLSASVGERVTITCRASQGISNHLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS x CD3HL GSGTDFTLTISSLQPEDFATYYCQQYSNLPYTFGGGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK

LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN

NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 841 BCMA-85 BC C6-97- VH CDR1 aa NFGMN GS 842 BCMA-85 BC-97- VH CDR2 aa WINTYTGESIYADDFKG 843 BCMA-85 BC C6-97- VH CDR3 aa GGVYGGYDAMDY G5 1 844 BCMA-85 C6-97- VL CDR1 aa RASQDISNYLN 845 BCMA-85 C6-97- VLCDR2 aa YTSRLHS 846 BCMA-85 BC C6-97- VLCDR3 aa QQGNTLPWT G5 847 BCMA-85 BC C6-97- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR G5 FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 848 BCMA-85 BC C6-97- VL aa DIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGSGS G5 GTDYTLTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESYADDFKGR 849 BCMA-85 BC C6-97- FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG G5 scFv aa GSDIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTLTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG BC C6-97- GSDIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGS 850 BCMA-85 HL x G5 HL bispecific a GSGTDYTLTISSLEPEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 851 BCMA-86 BC C6-98- VH CDR1 aa NFGMN CS _________________________________________________ 852 BCMA-86 C6-98- VH CDR2 aa WINTYTGESIYADDFKG C8 853 BMA-86 BC C6-98 853 BCMA-86 C-8 VH CDR3 aa GGVYGGYDAMDY 854 BCMA-86 C6-98- VL CDR1 aa RASQDISNYLN 855 BCMA-86 C6-98- VL CDR2 aa YTSRLHS 856 BCMA-86 BC C6-98- VL CDR3 aa QQGNTLPWT 857 BCMA-86 BC C6-98- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR C8 FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSS 858 BCMA-86 BC C6-98- VL a DIQMTQTPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGSGS C8 GTDYSLTISNLQPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 859 BCMA-86 BC C6-98- scFv aa FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG C8 GSDIQMTQTPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGS GSGTDYSLTISNLQPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG BC C6-98- GSDIQMTQTPSSLSASVGDRVT ITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGS 860 BCMA-86 HL x C8 HL bispecific GSGTDYSLTISNLQPEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 861 BCMA-87 C6-97- VH CDR1 aa NFGMN ____ A6 862 BCMA-87 BCC6-97- VH CDR2 as WINTYTGESIYADDFKG A6 863 BCMA-87 BC C6-97- VH CDR3 as GGVYGGYDAMDY 864 CA6 864 BCMA-87 BC C6-97- AL CDR1 as RASQDISNYLN AS6____________________________________ 865 BCMA-87 BC C6-97- VL CDR2 aa YTSRLHS _________A6 866 BCMA-87 B C6-97- VL CDR3 aa QQGNTLPWT 867 BCMA-87 BC C6-97- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR A6 FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 868 BCMA-87 BC C6-97- VL as DIQMTOSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGS A6 GTDYTLTISSLEQEDIATYFCQQGNTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 869 BCMA-87 BC C6-97- FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG A6 scFv 88 GSDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTLTISSLEQEDIATYFCQQGNTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG BC C6-97- GSDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLI YYTSRLHSGVPSRFSGS 870 BCMA-87 HL x A6 HL bispecific GSGTDYTLTISSLEQEDIATYFCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 871 BCMA-88 BC C6-98- VH CDR1 aa NFGMN C8-E3 ____ 872 BCMA-88 BC C6-98- VH CDR2 aa WINTYTGESIYADDFKG C8-E3 873 BCMA-88 BC C6-98- VH CDR3 aa GGVYGGYDAMDY C8-E3 874 BCMA-88 BC C6-98- VLCDR1 aa RASQDISNYLN C8-E3 VLD18 RSQSNL 875 BCMA-88 BC C6-98- VLCDR2 aa YTSRLHS CS-E3 3 876 BCMA-88 BC C6-98- VL CDR3 aa QSFATLPWT CC-E398 877 BCMA-88 BC 06-98- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR C8-E3I FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSS 878 BCMA-88 BC C6-98- VL aa DIQMTQTPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGSGS C8-E3 GTDYSLTISNLQPEDIATYYCQSFATLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 879 BCMA-88 BC CB-98- scFv aa FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG C8-E3 GSDIQMTQTPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGS GSGTDYSLTISNLQPEDIATYYCQSFATLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQTPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGS BCMA-88 HL x BC-3H bispecific GSGTDYSLTISNLQPEDIATYYCQSFATLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVOQKPGAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 881 BCMA-89 BC 06-98- VH CDR1 aa NFGMN _________A1-E3 V D1a FM 882 BCMA-89 BC C6-98 ______A1-E3 VH CDR2 88 WINTYTGESIYACDFKG 883 BCMA-89 C-98- VH CDR3 aa GGVYGGYDAMDY 884 BCMA-89 BC C6-98- VLCDR1 aa RASQDISNYLN __________A1-E3 ______________________________________ 885 BCMA-89 BC C6-98- VL CDR2 aa YTSRLHS __________A1-E3 886 BCMA-89 BC C6-98- VLCDR3 aa QSFATLPWT __________A1-E3 ____________________________________ 887 BCMA-89 BC C6-98- VH aa QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR A1-E3 FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 888 BCMA-89 BC C6-98- VL aa DIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGS A1-E3 GTDYTFTISNLQPEDIATYYCQSFATLPWTFGQGTKVEIK 889 BCMA-89 BC C6-98- scFv aa QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR ____ _________A1-E3 ____________________________________ FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYT FT I SNLQPEDIATYYCOSFATLPWTFGOGTKVEI K QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS 890 BCMA-89HLx -E3 HL bispecific GSGTDYTFTISNLQPEDIATYYCQSFATLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 891 BCMA-90 BC VH CDR aa NFGMN GS-E3 V D1a FM 892 BCMA-90 BC C6-97- VH CDR2 aa WINTYTGESIYADDFKG GS-E3 893 BCMA-90 BC 6-97- VH CDR3 aa GGVYGGYDAMDY 894 BCMA-90 BC C6-97- VLCDR1 aa RASQDISNYLN G5-E3 1LDR 1sRSDIN 895 BCMA-90 BC C6-97- VLCDR2 aa YTSRLHS G5-E3 VLD2 a YSLS 896 BCMA-90 BC C6-97- VLCDR3 aa QSFATLPWT G5-E3 VLD3a QSTLW 897 BCMA-90 BC C6-97- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR G5-E3 FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 898 BCMA-90 BC C6-97- VL aa DIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGSGS G5-E3 GTDYTLTISSLEPEDIATYYCQSFATLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 899 BCMA-90 BC C6-97- scFv aa FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG G5-E3 GSDIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTLTISSLEPEDIATYYCQSFATLPWTFGQGTKVEIK BCMA90 L xBC C6-97 BCMA-90 HL x G5-E3 HL bispecific QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR C3H x CD3 HL molecule FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTLTISSLEPEDIATYYCQSFATLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 901 BCMA-91 BC C6-97 A6-E3 VH CDR1 Ba NFGMN 902 BCMA-91 BC C6-97- VH CDR2 aa WINTYTGESIYADDFKG 903 BCMA-91 BC C6-97- VH CDR3 aa GGVYGGYDAMDY ____ ~~AB-E3 VHDR aa GVGYAD 904 BCMA-91 BC C6-97 A6-E3 VL CDR1 aa RASQDISNYLN 906 BCMA-91 BC C6-97- R2 Ba YTSRLHS A6-E3 VLCDR2a TRH 906 BCMA-91 BC C6-97- V CDR3 aa QSFATLPWT Ar.-E3 VC 907 BCMA-91 BC C6-97- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR A6-E3 FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 908 BCMA-91 BC C6-97- VL a DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGS A6-E3 GTDYTLTISSLEQEDIATYFCQSFATLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 909 BCMA-91 BC C6-97- s FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG A6-E3 GSDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTLTISSLEQEDIATYFCQSFATLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG BCMA-91 HLx BC C6-97- bispecific GSDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS CD3MH9 HL molecule aa GSGTDYTLTISSLEQEDIATYFCQSFATLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK x CD3 HL LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS

PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV

QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 911 BCMA-92 BC C6-97- VH CDR1 aa NFGMN BC C6-97 912 BCMA-92 GG9 VH CDR2 aa WINTYTGESIYADDFKG 913 BCMA-92 BC -97- VH CDR3 aa GGVYGGYDAMDY 914 BCMA-92 BC CG-97 G5-G9 VLCDR1 aa RASQDISNYLN 916 BCMA-92 BC C-97- VLCDR2 aa YTSRLHS ____ G5-G9 I_____________________I__________ 916 BCMA-92 BC C-97- VL CDR3 aa QHFRTLPWT 917 BCMA-92 BC C6-97- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR G5-G9 FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 918 BCMA-92 BC C6-97- VL aa DIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGSGS G&G9 GTDYTLTISSLEPEDIATYYCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 919 BCMA-92 BC C6-97- scFv aa FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG G5-G9 GSDIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTLTISSLEPEDIATYYCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG BC C6-97- GSDIQMTQSPSSLSASLGDRVTITCRASQDISNYLNWYQQKPDKAPKLLIYYTSRLHSGVPSRFSGS 920 BCMA-92 HL x G5-G9 HL bispecific aa GSGTDYTLTISSLEPEDIATYYCQHFRTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 921 BCMA-93 BC C-98- VH CDR1 aa NFGMN C8-G9 VHCDR aaWINTYTGESIYADDFKG 922 BCMA-93 BC C6-98- VH CDR2 aa WINTYTGESIYADDFKG CB-G9 ____ _______________________________ 923 BCMA-93 BC C6-98- VH CDR3 aa GGVYGGYDAMDY ________C8-G9 924 BCMA-93 BC C6-98- VLCDR1 aa RASQDISNYLN ______C8-G9 V D1a AQINL 925 BCMA-93 BC C6-98- V CDR2 aa YTSRLHS _________C8-G9 V D2a TRH 926 BCMA-93 BC C6-98- V CDR3 aa QHFRTLPWT _______C8-G9 VL1R a HRLW 927 BCMA-93 BC C6-98- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR C8-G9 FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSS 928 BCMA-93 BC C6-98- VL aa DIQMTQTPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGSGS C8-G9 GTDYSLTISNLQPEDIATYYCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 929 BCMA-93 BC C6-98- scFv aa FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG C8-G9 GSDIQMTQTPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGS GSGTDYSLTISNLQPEDIATYYCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSSDTSVSTAYLQINSLKAEDTAVYFCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQTPSSLSASVGDRVT ITCRASQDISNYLNWYQQKPGKALKLLIYYTSRLHSGVPSRFSGS BCMA-93 HL x BC-98 bispecific GSGTDYSLTISNLQPEDIATYYCQHFRTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK 930 C8G9 HL bispe CD3HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 931 BCMA-94 BC C6-97- VH CDR1 aa NFGMN A6-G 9 932 BCMA-94 BC C6-97 A6-G9 VH CDR2 aa WINTYTGESIYADDFKG 933 BCMA-94 BC CB-97 AB-G9 VH CDR3 aa GGVYGGYDAMDY 934 BCMA-94 BC C6-97- VL CDR1 aa RASQDISNYLN 935 BCMA-94 BC C6-97- VL CDR2 aa YTSRLHS A-G9s L 936 BCMA-94 BC C6-97- VLCDR3 aa QHFRTLPWT _________A6-G9 VLD3a QHRPW 937 BCMA-94 BC C6-97- VH aa QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR A6-G9 FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 938 BCMA-94 BC C6-97- VL aa DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGS A6-G9 GTDYTLTISSLEQEDIATYFCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 939 BCMA-94 BC C6-97- FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG A6-G9 scFv aa GSDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTLTISSLEQEDIATYFCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKVSCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSLDTSVTTAYLQINSLKDEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS 940 BCMA-94 HL x 6-- bispecific GSGTDYTLTISSLEQEDIATYFCQHFRTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK CD3 HL x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 941 BCMA-95 BC C6-98 ______A1-G9 VH CDR1 aa NFGMN 942 BCMA-95 BC C6-98- VH CDR2 aa WINTYTGESIYADDFKG Al-G9 943 BCMA-95 C6-98- VH CDR3 aa GGVYGGYDAMDY BCMA-95 A1-G9 944 BCMA-95 BC C6-98- VLCDR1 aa RASQDISNYLN _________Al-G9 945 BMA-95 BC C6-98 945 BCMA-95 Al-G9 VLCDR2 8a YTSRLHS 946 BCMA-95 BCC6-98- VL CDR3 aa QHFRTLPWT Al-G9 OQiRLW 947 BCMA-95 BC C6-98- VH aa QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR A1-G9 FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 948 BCMA-95 BC C6-98- VL aa DIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGS A1-G9 GTDYTFTISNLQPEDIATYFCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGES IYADDFKGR 949 BCMA-95 BCC9 Fv aa FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG Al-G9 GSDIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTFTISNLQPEDIATYFCQHFRTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS BCMA-95 HLx A1-9H bispecific GSGTDYTFTISNLQPEDIATYFCQHFRTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK 950 C3L A1-G9 HL bipc aa CD3HL x CD3 HL moecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV _QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 951 BCMA-96 BC C6 98- VHCDR1 aa NFGMN Al 952 BCMA-96 BC C6 98- VHCDR2 aa WINTYTGESIYADDFKG Al 953 BCMA-96 BC C6 98- VH CDR3 aa GGVYGGYDAMDY __________ Al 954 BCMA-96 BC C6 98- VL CDR1 aa RASQDISNYLN Al 955 BCMA-96 BC C6 98- VL CDR2 a YTSRLHS Al 956 BCMA-96 BC C6 98- VL CDR3 aa QQGNTLPWT Al 957 BCMA-96 BCC598 VH aa QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR Al FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSS 958 BCMA-96 BCC698 VL aa DIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGSGS Al GTDYTFTISNLQPEDIATYYCQQGNTLPWTFGQGTKVEIK QVQLVQSGSELKKPGASVKISCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGESIYADDFKGR 959 BCMA-96 BCC69 scFv aa FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG Al GSDIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTFTISNLQPEDIATYYCQQGNTLPWTFGQGTKVEIK 960 BCMA-96 HL x BC C6 98- bispecfic aa QVQLVQSGSELKKPGASVKI SCKASGYTFTNFGMNWVRQAPGQGLEWMGWINTYTGES IYADDFKGR CD3 HL Al HL molecule FVFSSDTSVSTAYLQINNLKAEDTAVYYCARGGVYGGYDAMDYWGQGTLVTVSSGGGGSGGGGSGGG x CD3HL GSDIQMTQSPSSLSASVGDRVTISCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLHSGVPSRFSGS GSGTDYTFTISNLQPEDIATYYCQQGNTLPWTFGQGTKVEIKSGGGGSEVQLVESGGGLVQPGGSLK LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 961 BCMA-97 BC B12-33- VH CDR1 aa NFDMA 962 BCMA-97 BC B12-33- VH CDR2 aa SITTGGGDTYYADSVKG ________G2-132 1 963 BCMA-97 BC B12-33- VH CDR3 aa HGYYDGYHLFDY G_____ 2-132 VH CO3a GYDYL 964 BCMA-97 2-33- VL CDR1 aa RASQGISNNLN 966 BCMA-97 BC B12-33- V CDR2 aa YTSNLQS ____ ~~~G2-B32 VLD2a YSNQ 966 BCMA-97 BC 812-33 92-32 VLCDR3 aa QQFTSLPYT 967 BCMA-97 BC B12-33- VH aa EVOLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR G2-B2 FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 968 BCMA-97 BC B12-33- VL aa DIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGSGS G2-B2 GTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 969 BCMA-97 BC B12-33- FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG G2-B2 GSDIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMNSLRAEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BCMA-97 HL x BC B12-33- bispecific GSDIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS CD3 HL G2-B2 HL molecule aa GSGTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK x CD3 HL LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS I PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 971 BCMA-98 BC B12-33- Dia FM A4-B32 VH CD1a FM BC B12-33 973 BCMA-98 BCB23-VH CDR3 aa HGYYDGYHLFDY A4-132 974 BM98 BC B12-33- VL CDR1 aa RANQGISNNLN BCMA-98 A4-132 975 BCMA-98 AB 32-3 VL CDR2 aa YTSNLQS 976 BMA-98 BC B12-33 976 BMA-9 VL CDR3 aa QQFTSLPYT 977 BCMA-98 BC B12-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFT FSNFDMAWVRQAPGKGLVW VSS ITTGGGDTYYADSVKGR A4-132 aa FTI SRDNAKSTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 98 BM-8 BC B12-33- V a DI QMTQSPSSLSASVGDRVTITCRANQGISNNLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFSGSGS 978 BCM-98 A4-132 V aa GTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGrFSNFDMAWVRQAPGKGLVWVSSTTGGGDTYYADSVXGR 979 BCMA-98 BC B12-33- FTISRDNAKSTLYLQMDSLRSEDTAVYYCVRHiCYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG A4-132 scFv aa GSDIQMTQSPSSLSASVGDRVTITCRANQGISNNLNWYQQKPGKAPKPLIYYTSNLQSGVPSRFsGS GSGTDYTLT ISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSS ITTGGGDTYYADSVKGR FTI SRDNAKSTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGOGTLVTVSSGGGGSGGGGSGGG GSDIQMTQSPSSLSASVGDRVTITCRANQGI SNNLNWYQQKPGKAPKPLI YYTSNLQSGVPSRFSGS 90 BCMA-98 HL BC A12-3 HL bCeaiSGTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK CD L xCD3 HL molecule a LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRH-GNFGNSYI SYWAYWGQGTLVTVSSGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLI GGTKFLAPCTPARFSGSLLGGKAALTLSGV SC B1-33-QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 981 BCMA-99 BC 12-33- Ri aa NFDMA 982 BCMA-99 BC B812-33- VH CDR2 aa SITTGGGDTYYADSVKG ____________A5-RB2 983 BCMA-99 BC B12-33- VH CDR3 aa HGYYDGYHLFDY 984 BCMA-99 BC B12-33- VLCDR1 aa RASQGISNNLN A5-132 VC 985 BCMA-99 BC B12-33- VLCDR2 aa YTSNLQS AS- B2 LD2a TNQ 986 BCMA-99 BC B12-33- VLCDR3 aa QQFTSLPYT 987 BCMA-99 BC B12-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR A-1B2 FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 988 BCMA-99 BC 812-33- V aa DIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGSGS A-1B2 GTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 989 BCMA-99 BC B12-33- FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG A5-B2 sFv 88 GSDIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC B12-33- GSDIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS 990 BCMA-99 HL x A5-B2 HL bispecific GSGTDYTLTISSLQPEDFATYYCQQFTSLPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK 90CD3HL 8812 La x CD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVAR I RSKYNNYATYYADSVKDRFT ISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL 991 BCMA-100 BC B12-33- VH CDR1 aa NFDMA AS-C 10 992 BCMA-100 BC B12-33- VH CDR2 aa SITTGGGDTYYADSVKG 993 BCMA-100 BC B12-33- VH CDR3 8a HGYYDGYHLFDY AS-ClO HCR aHYDYLY BC B12-33 994 BCMA-100 BCB- VL CDR1 aa RASQGISNNLN BC B12-33 995 BCMA-100 BCB VL CDR2 aa YTSNLQS AS-Cl1 BC B12-33 996 BCMA-100 A5-C1O VL CDR3 aa QQFAHLPYT 997 BCMA-100 BC B12-33- VH aa EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR AS-C1O FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSS 998 BCMA-100 BC B12-33- VL aa DIOMTOSPSSMSASVGDRVTITCRASOGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGSGS AS-C1O GTDYTLTISSLQPEDFATYYCQQFAHLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDNAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR 999 BCMA-100 BC B12-33- scFv aa FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG A9C10 BCMA-0GSDIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS GSGTDYTLTISSLQPEDFATYYCQQFAHLPYTFGQGTKLEIK EVQLVESGGGLVQPGGSLRLSCAASGFTFSNFDMAWVRQAPGKGLVWVSSITTGGGDTYYADSVKGR FTISRDNAKNTLYLQMDSLRSEDTAVYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGGG BC812-33- GSDIQMTQSPSSMSASVGDRVTITCRASQGISNNLNWYQQKPGKAPKSLIYYTSNLQSGVPSRFSGS BCMA-100HL 1AC10HL bispecific GSGTDYTLTISSLQPEDFATYYCQQFAHLPYTFGQGTKLEIKSGGGGSEVQLVESGGGLVQPGGSLK xCD3 HL xCD3 HL molecule LSCAASGFTFNKYAMNWVRQAPGKGLEWVARIRSKYNNYATYYADSVKDRFTISRDDSKNTAYLQMN NLKTEDTAVYYCVRHGNFGNSYISYWAYWGQGTLVTVSSGGGGSGGGGSGGGGSQTVVTQEPSLTVS PGGTVTLTCGSSTGAVTSGNYPNWVQQKPGQAPRGLIGGTKFLAPGTPARFSGSLLGGKAALTLSGV QPEDEAEYYCVLWYSNRWVFGGGTKLTVL atgttgcagatggctgggcagtgctcccaaaatgaatattttgacagtttgttgcatgcttgcatac cttgtcaacttcgatgttcttctaatactcctcctctaacatgtcagcgttattgtaatgcaagtgt gaccaattcagtgaaaggaacgaatgcgattctctggacctgtttgggactgagcttaataatttct ttggcagttttcgtgctaatgtttttgctaaggaagataaactctgaaccattaaaggacgagttta 1001 human BCMA human na aaaacacaggatcaggtctcctgggcatggctaacattgacctggaaaagagcaggactggtgatga aattattcttccgagaggcctcgagtacacggtggaagaatgcacctgtgaagactgcatcaagagc aaaccgaaggtcgactctgaccattgctttccactcccagctatggaggaaggcgcaaccattcttg tcaccacgaaaacgaatgactattgcaagagcctgccagctgctttgagtgctacggagatagagaa atcaatttctgctaggtaa MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIIS 1002 human BCMA human aa LAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKS KPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR 1003 mouse BCMA munne na atggcgcaacagtgtttccacagtgaatattttgacagtctgctgcatgcttgcaaaccgtgtcact tgcgatgttccaaccctcctgcaacctgtcagccttactgtgatccaagcgtgaccagttcagtgaa agggacgtacacggtgctctggatcttcttggggctgaccttggtcctctctttggcacttttcaca atctcattcttgctgaggaagatgaaccccgaggccctgaaggacgagcctcaaagcccaggtcagc ttgacggatcggctcagctggacaaggccgacaccgagctgactaggatcagggctggtgacgacag gatctttccccgaagcctggagtatacagtggaagagtgcacctgtgaggactgtgtcaagagcaaa cccaagggggattctgaccatttcttcccgcttccagccatggaggagggggcaaccattcttgtca ccacaaaaacgggtgactacggcaagtcaagtgtgccaactgctttgcaaagtgtcatggggatgga gaagccaactcacactagataa MAQQCFHSEYFDSLLHACKPCHLRCSNPPATCQPYCDPSVTSSVKGTYTVLWIFLGLTLVLSLALFT 1004 mouse BCMA murine aa ISFLLRKMNPEALKDEPQSPGQLDGSAQLDKADTELTRIRAGDDRIFPRSLEYTVEECTCEDCVKSK PKGDSDHFFPLPAMEEGATILVTTKTGDYGKSSVPTALQSVMGMEKPTHTR atgttgcagatggctcggcagtgctcccaaaatgaatattttgacagtttgttgcatgattgcaaac cttgtcaacttcgatgttctagtactcctcctctaacatgtcagcgttattgcaatgcaagtatgac caattcagtgaaaggaatgaatgcgattctctggacctgtttgggactgagcttgataatttctttg gcagttttcgtgctaacgtttttgctaaggaagatgagctctgaaccattaaaggatgagtttaaaa 1005 macaque BCMA rhesus na acacaggatcaggtctcctgggcatggctaacattgacctggaaaagggcaggactggtgatgaaat tgttcttccaagaggcctggagtacacggtggaagaatgcacctgtgaagactgcatcaagaataaa ccaaaggttgattctgaccattgctttccactcccagccatggaggaaggcgcaaccattctcgtca ccacgaaaacgaatgactattgcaatagcctgtcagCtgctttgagtgttacggagatagagaaatc aatttctgctaggtaa MLQMARQCSQNEYFDSLLHDCKPCQLRCSSTPPLTCQRYCNASMTNSVKGMNAILWTCLGLSLIISL 1006 macaque BCMA rhesus aa AVFVLTFLLRKMSSEPLKDEFKNTGSGLLGMANIDLEKGRTGDEIVLPRGLEYTVEECTCEDCIKNK PKVDSDHCFPLPAMEEGATILVTTKTNDYCNSLSAALSVTEIEKSISAR 1007 huBCMA ECD = positions human aa MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA 1-54 of SEQ ID NO: 1002 ____________________________________ muB~CMA ECD = positons 1008 1-49of SEQ ID NO:1004 munne aa MAQQCFHSEYFDSLLHACKPCHLRCSNPPATCQPYCDPSVTSSVKGTYT 1009hu BMA ED / l muine chimen c 1009 hu BCMAmECD/Emunne u aa MAQQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA 10 hu BCMAECD/E2munne m aa MLQMAGQCFHSEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA 1011 hu BCMA ECD/ E3 munne hu/mrmu aa MLQMAGQCSQNEYFDSLLHACIPCHLRCSNPPATCQPYCNASVTNSVKGTNA 1012 hu BCMA ECD/ E4 munne C aa MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCDPSVTSSVKGTYT 1013hu BMA CD /E5 mnne Chimen~c 101 h BMAEC IE5mune hu /mu aa MLQMAGQCSQNEYFDSLLHACKPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNA 1014hu BMA ED / 6 muine chimeric a MQAQSNYDLHCPLRSTPTQYNSVSKGA 1014 hu BMA ECD I 6 munne / mu aa LQ GQSNYSLHC CLRSTPTQYNAVSKTA chimeric 1015 hu BCMA ECD / E7 murine hu /m aa MLQMAGQCSQNEYFDSLLHACI PCQLRCSSNTPPLTCQPYCNASVTNSVKGTNA 1016 hu BCMA epitope cluster 3 human aa CQLRCSSNTPPLTCQRYC 1017 mac BCMA epitope cluster 3 macaque aa CQLRCSSTPPLTCQRYC 1018 hu BCMA epitope duster 1 human aa MLQMAGQ 1019 hu BCMA epitopedcuster 4 human aa NASVTNSVKGTNA 1020 mac BCMA epitope duster 1 macaque aa MLQMARQ 1021 mac BCMA epitope duster 4 macaque aa NASMTNSVKGMNA 1022 BCMA-101 BC 5G9 VH CDR1 aa GFTFSNYDMA 1023 BCMA-101 BC 5G9 VH CDR2 aa SIITSGGDNYYRDSVKG 1024 BCMA-101 BC 5G9 VH CDR3 aa HDYYDGSYGFAY 1025 BCMA-101 BC 5G9 VL CDR1 aa KASQSVGINVD 1026 BCMA-101 BC 5G9 VL CDR2 8a GASNRHT 1027 BCMA-101 BC 5G9 ALCDR3 aa LQYGSIPFT EVQLVESGGGLVQPGRSLKLSCAASGFTFSNYDMAWVRQAPTKGLEWVAS IITSGGDNYYRDSVKGR 1028 BCMA-101 BC 5G9 VH aa FTVSRDNAKSTLYLQMDSLRSEDTATYYCVRHDYYDGSYGFAYWGQGTLVTVSS 1029BCM-10 BC G9 aa ETVMTQSPTSMSTSIGERVTLNCKASQSVGINVDWYQQTPGQSPKLLI YGASNRHTGVPDRFTGSGF 1029BCM-1O BC59 V aa GRDFTLTISNVEAEDLAVYYCLQYGSIPFTFGSGTKLELK EVQLVESGGGLVQPGRSLKLSCAASGFTFSNYMAWVRQAPTKGLEWVAS IITSGGDNYYRDSVKGR FTVSRDNAKSTLYLQMDSLRSEDTATYYCVRHDYYDGSYGFAYWGQGTLVTVSSGGGGSGGGGGSGG 1030 BCMA-101 BC 5G9 scFv aa GGSETVMTQSPTSMSTSIGERVTLNCKASQSVGINVDWYQQTPGQSPKLLIYGASNRHTGVPDRFTG SGFGRDFTLTISNVEAEDLAVYYCLQYGS IPFTFGSGTKLELK 1031 BCMA-102 BC 244-A7 VH CDR1 aa GYTFTNHIIH 1032 BCMA-102 BC 244-A7 VH CDR2 aa YINPYNDDTEYNEKFKG 1033 BCMA-102 BC 244-A7 VH CDR3 aa DGYYRDMDVMDY 1034 BCMA-102 BC 244-A7 VL CDR1 aa RASQDISNYLN 1036 BCMA-102 BC 244-A7 VL CDR2 aa YTSRLHS 1036 BCMA-102 BC 244-A7 VL CDR3 aa QQGNTLPWT EVQLVEQSGPELVKPGASVKMSCKASGYT FTNHI IHWVKQKPGQGLEWIGY INPYNDDTEYNEKFKG 1037 BCMA-102 BC 244-A7 VH Ba KATLTSDKSSTTAYMELSSLTSEDSAVYYCARDGYYRDMDVMDYWGQGTTVTVSS ELVMTQTPSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGS 1038 BCMA-102 BC 244-A7 VL 88 GTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIK EVQLVEQSGPELVKPGASVKMSCKASGYTFTNHIIHWVKQKPGQGLEWIGYINPYNDDTEYNEKFKG KATLTSDKSSTTAYMELSSLTSEDSAVYYCARDGYYRDMDVMDYWGQGTTVTVSSGGGGSGGGGSGG 1039 BCMA-102 BC 244-Al SCFV aa GGSELVMTQTPSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSG SGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIK 1040 BCMA-103 BC 263-A4 VH CDR1 aa GFTFSNYDMA 1041 BCMA-103 BC 263-A4 VH CDR2 aa SISTRGDITSYRDSVKG 1042 BCMA-103 BC 263-A4 VH CDR3 aa QDYYTDYMGFAY 1043 BCMA-103 BC 263-A4 VL COR1 aa RASEDIYNGLA 1044 BCMA-103 BC 263-A4 VL CDR2 aa GASSLQD 1045 BCMA-103 BC 263-A4 VL CDR3 aa QQSYKYPLT 1046 BCMA-103 BC 263-A4 VH aa EVQLVEESGGGLLQPGRSLKLSCAASGFTFSNYDMAWVRQAPTKGLEWVASISTRGDITSYRDSVKG RFTISRDNAKSTLYLQMDSLRSEDTATYYCARQDYYTDYMGFAYWGQGTLVTVSS ELVMTQSPASLSASLGETVTIECRASEDIYNGLAWYQQKPGKSPQLLIYGASSLQDGVPSRFSGSGS 1047 BCMA-103 BC 263-A4 VL aa GTQYSLKISGMQPEDEANYFCQQSYKYPLTFGSGTKLELK EVQLVEESGGGLLQPGRSLKLSCAASGFTFSNYDMAWVRQAPTKGLEWVASISTRGDITSYRDSVKG RFTI SRDNAKSTLYLQMDSLRSEDTATYYCARQDYYTDYMGFAYWGQGTLVTVSSGGGGSGGGGSGG 1048 BCMA-103 BC 263-A4 scFv 88 GELVMTQSPASLSASLGETVTIECRASEDIYNGLAWYQQKPGKSPQLLIYGASSLQDGVPSRFSGSG SGTQYSLKISGN1QPEDEANYF'CQQSYKYPLTFGSGTKLELKGS 1049 BCMA-l04 BC 271-C3 VH CDR1 aa GFTFSNFDMA 1050 BCMA-104 BC 271-C3 VH CDR2 aa ISITTGGGDTYYRDSVKG 1051 BCMA-104 BC 271-C3 VH CDR3 aa HGYYDGYHLFDY 1052 BCMA-104 BC 271-C3 ALCDR1 aa RASQGISNYL 1053 BCMA-104 BC 271-C3 ALCDR2 88 YTSNLQS 1054 BCMA-104 BC 271-C3 VL CDR3 aa QQYDISSYT EVQLVEESGGGLVQPGRSLKLSCAASGFTFSNFDMAWVRQAPTRGLEWVAS rTTGGGDTYYRDSVKG 1055 BCMA-104 BC 271-C3 VH 88 RFTISRDNAKSTLYLQMDSLRSEDTATYYCVRHGYYDGYHLFDYWGQGASVTVSS 1066BCM-lD BC 71-3 V aa ELVMTQTPSSMPASLGERVTI SCRASQGISNYLNWYQQKPDGTIKPLIYYTSNLQSGVPSRFSGSGs 1056BCM-10 BC 71-3 V a8 GTDYSLTINSLEPEDFAVYYCQQYDISSYTFGAGTKLEIK EVQLVEESGGGLVQPGRSLKLSCAASGFTFSNFDMAWVRQAPTRGLEWVAS ITTGGGDTYYRDSVKG RFTISRDNAKSTLYLQMDSLRSEDTATYYCVRHGYYDGYHLFDYWGQGASVTVSSGGGGSGGGGSGG 1057 BCMA-104 BC 271-C3 scFv 88 GGSELVHTQTPSSMPASLGERVTISCRASQGISNYLNWYOOKPDGTIKPLIYYTSNLQSGVPSRFSG SGSGTDYSLTINSLEPEDFAVYYCQQYDISSYTFGAGTKLEIK 1058 BCMA-105 BC 265-E5 VH CDRi 88 GFTFSNFDMA 1059 BCMA-105 BC 265-E5 VH CDR2 88 SITTGGGDTYYRDSVKG 1060 BCMA-105 BC 265-E5 VH CDR3 88 HGYYDGYHLFDY 1061 BCMA-105 BC 265-E5 VLCDR1 88 RASQGISNHLN 1062 BCMA-10S BC 265-ES VL CDR2 88 YTSNLQS 1063 BCMA-105 BC 265-E5 VL CDR3 88 QQYDSFPLT 1064 BCMA-105 BC265-ES VH aa EVQLVEESGGGLVQPGRSLKLSCAASGFTFSNFDMAWVRQAPTRGLEWVASITTGGGDTYYRDSVKG RFTISRDNAKSTLYLQMDSLRSEDTATYYCVRHGYYDGYHLFDYWGQGTLVTVSS ELVMTQTPSSMPASLGERVTISCRASQGISNHLNWYQQKPDGTIKPLIYYTSNLQSGVPSRFSGSGS 1065 BCMA-105 BC265-E5 VL 88 GTDYSLTISSLEPEDFAMYYCQQYDSFPLTFGSGTKLEIK EVQLVEESGGGLVQPGRSLKLSCAASGFTFSNFDMAWVRQAPTRGLEWVASITTGGGDTYYRDSVKG 1066 BCMA-105 BC 265-E5 scFv aa RFTISRDNAKSTLYLQMDSLRSEDTATYYCVRHGYYDGYHLFDYWGQGTLVTVSSGGGGSGGGGSGG GGSELVMTQTPSSMPASLGERVTISCRASQGISNHLNWYQQKPDGTIKPLIYYTSNLQSGVPSRFSG SGSGTDYSLTISSLEPEDFAMYYCQQYDSFPLTFGSGTKLEIK 1067 BCMA-106 BC271-B12 VH CDR1 aa GFTFSNFDMA 1068 BCMA-106 BC271-B12 VH CDR2 aa SITTGGGDTYYRDSVKG 1069 BCMA-106 BC271-B12 VH CDR3 aa HGYYDGYHLFDY 1070 BCMA-106 BC271-B12 VL CDR1 aa RASQGISNNLN 1071 BCMA-106 BC271-B12 VL CDR2 aa YTSNLQS 1072 BCMA-106 BC271-B12 VL CDR3 aa QQFDTSFYT 1073 BCMA-106 BC271-B12 VH aa EVQLVEESGGGLVQPGRSLKLSCAASGFTFSNFDMAWVRQAPTRGLEWVASITTGGGDTYYRDSVKG RFrISRDNAKSTLYLQMDSLRSEDTATYYCVRHGYYDGYHLFDYWGQGVMVTVSS 1074 BCMA-106 BC271-B12 VL aa ELVMTQTPSSMPASLGERVTISCRASQGISNNLNWYQQKPDGTIKPLIYYTSNLQSGVPSRFSGSGS GTDYSLTISSLEPEDFAMYYCQQFDTSPYTFGAGTKLEIK EVQLVEESGGGLVQPGRSLKLSCAASGFTFSNFDMAWVRQAPTRGLEWVASITTGGGDTYYRDSVKG 1075 BCMA-106 BC271-B12 scFv aa RFTISRNAKSTLYLQMDSLRSEDTATYYCVRHGYYDGYHLFDYWGQGVMVTVSSGGGGSGGGGSGG GGSELVMTQTPSSMPASLGERVTISCRASQGISNNLNWYQQKPDGTIKPLIYYTSNLQSGVPSRFSG SGSGTDYSLTISSLEPEDFAMYYCQQFDTSPYTFGAGTKLEIK 1076 BCMA-107 BC 247-A4 VH CDR1 aa GYSFPDYYIN 1077 BCMA-107 BC 247-A4 VH CDR2 aa WIYFASGNSEYNE 1078 BCMA-107 BC 247-A4 VH CDR3 aa LYDYDWYFDV 1079 BCMA-107 BC 247-A4 VL CDR1 aa RSSQSLVHSNGNTYLH 1080 BCMA-107 BC 247-A4 VL CDR2 aa KVSNRFS 1081 BCMA-107 BC 247-A4 VL CDR3 aa SQSTHVPYT 1082 BCMA-107 BC 247-A4 VH aa EVQLVEQSGPELVKPGASVKISCKVSGYSFPDYYINWVKQRPGQGLEWIGWIYFASGNSEYNERFTG KATLTVDTSSNTAYMQLSSLTSEDTAVYFCASLYDYDWYFDVWGQGTTVTVSS ELVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRF 1083 BCMA-107 BC 247-A4 VL aa SGSGSGADFTLKISRVEAEDLGVYFCSQSTHVPYTFGGGTKLEIK EVQLVEQSGPELVKPGASVKISCKVSGYSFPDYYINWVKQRPGQGLEWIGWIYFASGNSEYNERFTG KATLTVDTSSNTAYMQLSSLTSEDTAVYFCASLYDYDWYFDVWGQGTTVTVSSGGGGSGGGGSGGGG 1084 BCMA-107 BC 247-A4 scFv 88 SELVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDR FSGSGSGADFTLKISRVEAEDLGVYFCSQSTHVPYTFGGGTKLEIK 1085 BCMA-108 BC 246-B6 VH CDR1 aa GYSFPDYYIN 1086 BCMA-108 BC 246-B6 VH CDR2 aa WIYFASGNSEYNE 1087 BCMA-108 BC 246-B6 VH CDR3 aa LYDYDWYFDV 1088 BCMA-108 BC 246-B6 VL CDR1 aa RSSQSLVHSNGNTYLH 1089 BCMA-108 BC 246-B6 VL CDR2 aa KVSNRFS 1090 BCMA-108 BC 246-B6 VL CDR3 sa. FQGSHVPWT EVQLVEQSGPQLVKPGASVKISCKVSGYSFPDYYINWVKQRPGQGLEWIGWIYFASGNSEYNERFTG 1091 BCMA-108 BC 246-86 VH 88 KATLTVDTSSNTAYMQLSSLTSEDTAVYFCASLYDYDWYFDVWGQGTTVTVSS 1092 BCMA-108 BC246B6 VL aa ELVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPGRF SGSGSGTDFTLKINRVEAEDLGVYYCFQGSHVPWTFGGGTKLEIK EVQLVEQSGPQLVKPGASVKISCKVSGYSFPDYYINWVKQRPGQGLEWIGWIYFASGNSEYNERFTG KATLTVDTSSNTAYMQLSSLTSEDTAVYFCASLYDYDWYFDVWGQGTTVTVSSGGGGSGGGGSGGGG 1093 BCMA-108 BC 246-B6 scFv 88 SELVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFSGVPGR

FSGSGSGTDFTLKINRVEAEDLGVYYCFQGSHVPWTFGGGTKLEIK

Claims (26)

1. A binding molecule which is at least bispecific comprising a first and a second binding domain, wherein (a) the first binding domain is capable of binding to epitope cluster 3 of BCMA (CQLRCSSNTPPLTCQRYC); and (b) the second binding domain is capable of binding to the T cell CD3 receptor complex; and wherein epitope cluster 3 of BCMA corresponds to amino acid residues 24 to 41 of the sequence as depicted in SEQ ID NO: 1002.

2. The binding molecule according to claim 1, wherein the first binding domain is further capable of binding to epitope cluster 3 of macaque BCMA (CQLRCSSTPPLTCQRYC).

3. The binding molecule according to claim 1 or 2, wherein the second binding domain is capable of binding to CD3 epsilon.

4. The binding molecule according to any one of the preceding claims, wherein the second binding domain is capable of binding to human CD3 and to macaque CD3.

5. The binding molecule according to any one of the preceding claims, wherein the first and/or the second binding domain are derived from an antibody.

6. The binding molecule according to claim 5, which is selected from the group consisting of (scFv) 2 , (single domain mAb) 2 , scFv-single domain mAb, diabodies and oligomers thereof.

7. The binding molecule according to any one of the preceding claims, wherein the first binding domain comprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 and a VL region comprising CDR-L1, CDR-L2 and CDR-L3 selected from the group consisting of: (1) CDR-H1 as depicted in SEQ ID NO: 1, CDR-H2 as depicted in SEQ ID NO: 2, CDR-H3 as depicted in SEQ ID NO: 3, CDR-L1 as depicted in SEQ ID NO: 4, CDR-L2 as depicted in SEQ ID NO: 5 and CDR-L3 as depicted in SEQ ID NO: 6; 185 (2) CDR-H1 as depicted in SEQ ID NO: 11, CDR-H2 as depicted in SEQ ID NO: 12, CDR-H3 as depicted in SEQ ID NO: 13, CDR-L1 as depicted in SEQ ID NO: 14, CDR-L2 as depicted in SEQ ID NO: 15 and CDR-L3 as depicted in SEQ ID NO: 16; (3) CDR-H1 as depicted in SEQ ID NO: 21, CDR-H2 as depicted in SEQ ID NO: 22, CDR-H3 as depicted in SEQ ID NO: 23, CDR-L1 as depicted in SEQ ID NO: 24, CDR-L2 as depicted in SEQ ID NO: 25 and CDR-L3 as depicted in SEQ ID NO: 26; (4) CDR-H1 as depicted in SEQ ID NO: 31, CDR-H2 as depicted in SEQ ID NO: 32, CDR-H3 as depicted in SEQ ID NO: 33, CDR-L1 as depicted in SEQ ID NO: 34, CDR-L2 as depicted in SEQ ID NO: 35 and CDR-L3 as depicted in SEQ ID NO: 36; (5) CDR-H1 as depicted in SEQ ID NO: 41, CDR-H2 as depicted in SEQ ID NO: 42, CDR-H3 as depicted in SEQ ID NO: 43, CDR-L1 as depicted in SEQ ID NO: 44, CDR-L2 as depicted in SEQ ID NO: 45 and CDR-L3 as depicted in SEQ ID NO: 46; (6) CDR-H1 as depicted in SEQ ID NO: 51, CDR-H2 as depicted in SEQ ID NO: 52, CDR-H3 as depicted in SEQ ID NO: 53, CDR-L1 as depicted in SEQ ID NO: 54, CDR-L2 as depicted in SEQ ID NO: 55 and CDR-L3 as depicted in SEQ ID NO: 56; (7) CDR-H1 as depicted in SEQ ID NO: 61, CDR-H2 as depicted in SEQ ID NO: 62, CDR-H3 as depicted in SEQ ID NO: 63, CDR-L1 as depicted in SEQ ID NO: 64, CDR-L2 as depicted in SEQ ID NO: 65 and CDR-L3 as depicted in SEQ ID NO: 66; (8) CDR-H1 as depicted in SEQ ID NO: 71, CDR-H2 as depicted in SEQ ID NO: 72, CDR-H3 as depicted in SEQ ID NO: 73, CDR-L1 as depicted in SEQ ID NO: 74, CDR-L2 as depicted in SEQ ID NO: 75 and CDR-L3 as depicted in SEQ ID NO: 76; (9) CDR-H1 as depicted in SEQ ID NO: 161, CDR-H2 as depicted in SEQ ID NO: 162, CDR-H3 as depicted in SEQ ID NO: 163, CDR-L1 as depicted in SEQ ID NO: 164, CDR-L2 as depicted in SEQ ID NO: 165 and CDR-L3 as depicted in SEQ ID NO: 166; (10) CDR-H1 as depicted in SEQ ID NO: 171, CDR-H2 as depicted in SEQ ID NO: 172, CDR-H3 as depicted in SEQ ID NO: 173, CDR-L1 as depicted in SEQ ID NO: 174, 186 CDR-L2 as depicted in SEQ ID NO: 175 and CDR-L3 as depicted in SEQ ID NO: 176; (11) CDR-H1 as depicted in SEQ ID NO: 181, CDR-H2 as depicted in SEQ ID NO: 182, CDR-H3 as depicted in SEQ ID NO: 183, CDR-L1 as depicted in SEQ ID NO: 184, CDR-L2 as depicted in SEQ ID NO: 185 and CDR-L3 as depicted in SEQ ID NO: 186; (12) CDR-H1 as depicted in SEQ ID NO: 191, CDR-H2 as depicted in SEQ ID NO: 192, CDR-H3 as depicted in SEQ ID NO: 193, CDR-L1 as depicted in SEQ ID NO: 194, CDR-L2 as depicted in SEQ ID NO: 195 and CDR-L3 as depicted in SEQ ID NO: 196; (13) CDR-H1 as depicted in SEQ ID NO: 201, CDR-H2 as depicted in SEQ ID NO: 202, CDR-H3 as depicted in SEQ ID NO: 203, CDR-L1 as depicted in SEQ ID NO: 204, CDR-L2 as depicted in SEQ ID NO: 205 and CDR-L3 as depicted in SEQ ID NO: 206; (14) CDR-H1 as depicted in SEQ ID NO: 211, CDR-H2 as depicted in SEQ ID NO: 212, CDR-H3 as depicted in SEQ ID NO: 213, CDR-L1 as depicted in SEQ ID NO:214, CDR-L2 as depicted in SEQ ID NO: 215 and CDR-L3 as depicted in SEQ ID NO: 216; (15) CDR-H1 as depicted in SEQ ID NO: 221, CDR-H2 as depicted in SEQ ID NO: 222, CDR-H3 as depicted in SEQ ID NO: 223, CDR-L1 as depicted in SEQ ID NO: 224, CDR-L2 as depicted in SEQ ID NO: 225 and CDR-L3 as depicted in SEQ ID NO: 226; (16) CDR-H1 as depicted in SEQ ID NO: 311, CDR-H2 as depicted in SEQ ID NO: 312, CDR-H3 as depicted in SEQ ID NO: 313, CDR-L1 as depicted in SEQ ID NO: 314, CDR-L2 as depicted in SEQ ID NO: 315 and CDR-L3 as depicted in SEQ ID NO: 316; (17) CDR-H1 as depicted in SEQ ID NO: 321, CDR-H2 as depicted in SEQ ID NO: 322, CDR-H3 as depicted in SEQ ID NO: 323, CDR-L1 as depicted in SEQ ID NO: 324, CDR-L2 as depicted in SEQ ID NO: 325 and CDR-L3 as depicted in SEQ ID NO: 326; (18) CDR-H1 as depicted in SEQ ID NO: 331, CDR-H2 as depicted in SEQ ID NO: 332, CDR-H3 as depicted in SEQ ID NO: 333, CDR-L1 as depicted in SEQ ID NO: 334, CDR-L2 as depicted in SEQ ID NO: 335 and CDR-L3 as depicted in SEQ ID NO: 336; 187 (19) CDR-H1 as depicted in SEQ ID NO: 341, CDR-H2 as depicted in SEQ ID NO: 342, CDR-H3 as depicted in SEQ ID NO: 343, CDR-L1 as depicted in SEQ ID NO: 344, CDR-L2 as depicted in SEQ ID NO: 345 and CDR-L3 as depicted in SEQ ID NO: 346; (20) CDR-H1 as depicted in SEQ ID NO: 351, CDR-H2 as depicted in SEQ ID NO: 352, CDR-H3 as depicted in SEQ ID NO: 353, CDR-L1 as depicted in SEQ ID NO: 354, CDR-L2 as depicted in SEQ ID NO: 355 and CDR-L3 as depicted in SEQ ID NO: 356; (21) CDR-H1 as depicted in SEQ ID NO: 361, CDR-H2 as depicted in SEQ ID NO: 362, CDR-H3 as depicted in SEQ ID NO: 363, CDR-L1 as depicted in SEQ ID NO: 364, CDR-L2 as depicted in SEQ ID NO: 365 and CDR-L3 as depicted in SEQ ID NO: 366; (22) CDR-H1 as depicted in SEQ ID NO: 371, CDR-H2 as depicted in SEQ ID NO: 372, CDR-H3 as depicted in SEQ ID NO: 373, CDR-L1 as depicted in SEQ ID NO: 374, CDR-L2 as depicted in SEQ ID NO: 375 and CDR-L3 as depicted in SEQ ID NO: 376; (23) CDR-H1 as depicted in SEQ ID NO: 381, CDR-H2 as depicted in SEQ ID NO: 382, CDR-H3 as depicted in SEQ ID NO: 383, CDR-L1 as depicted in SEQ ID NO: 384, CDR-L2 as depicted in SEQ ID NO: 385 and CDR-L3 as depicted in SEQ ID NO: 386; (24) CDR-H1 as depicted in SEQ ID NO: 581, CDR-H2 as depicted in SEQ ID NO: 582, CDR-H3 as depicted in SEQ ID NO: 583, CDR-L1 as depicted in SEQ ID NO: 584, CDR-L2 as depicted in SEQ ID NO: 585 and CDR-L3 as depicted in SEQ ID NO: 586; (25) CDR-H1 as depicted in SEQ ID NO: 591, CDR-H2 as depicted in SEQ ID NO: 592, CDR-H3 as depicted in SEQ ID NO: 593, CDR-L1 as depicted in SEQ ID NO: 594, CDR-L2 as depicted in SEQ ID NO: 595 and CDR-L3 as depicted in SEQ ID NO: 596; (26) CDR-H1 as depicted in SEQ ID NO: 601, CDR-H2 as depicted in SEQ ID NO: 602, CDR-H3 as depicted in SEQ ID NO: 603, CDR-L1 as depicted in SEQ ID NO: 604, CDR-L2 as depicted in SEQ ID NO: 605 and CDR-L3 as depicted in SEQ ID NO: 606; (27) CDR-H1 as depicted in SEQ ID NO: 611, CDR-H2 as depicted in SEQ ID NO: 612, CDR-H3 as depicted in SEQ ID NO: 613, CDR-L1 as depicted in SEQ ID NO: 614, 188 CDR-L2 as depicted in SEQ ID NO: 615 and CDR-L3 as depicted in SEQ ID NO: 616; (28) CDR-H1 as depicted in SEQ ID NO: 621, CDR-H2 as depicted in SEQ ID NO: 622, CDR-H3 as depicted in SEQ ID NO: 623, CDR-L1 as depicted in SEQ ID NO: 624, CDR-L2 as depicted in SEQ ID NO: 625 and CDR-L3 as depicted in SEQ ID NO: 626; (29) CDR-H1 as depicted in SEQ ID NO: 631, CDR-H2 as depicted in SEQ ID NO: 632, CDR-H3 as depicted in SEQ ID NO: 633, CDR-L1 as depicted in SEQ ID NO: 634, CDR-L2 as depicted in SEQ ID NO: 635 and CDR-L3 as depicted in SEQ ID NO: 636; (30) CDR-H1 as depicted in SEQ ID NO: 641, CDR-H2 as depicted in SEQ ID NO: 642, CDR-H3 as depicted in SEQ ID NO: 643, CDR-L1 as depicted in SEQ ID NO: 644, CDR-L2 as depicted in SEQ ID NO: 645 and CDR-L3 as depicted in SEQ ID NO: 646; (31) CDR-H1 as depicted in SEQ ID NO: 651, CDR-H2 as depicted in SEQ ID NO: 652, CDR-H3 as depicted in SEQ ID NO: 653, CDR-L1 as depicted in SEQ ID NO: 654, CDR-L2 as depicted in SEQ ID NO: 655 and CDR-L3 as depicted in SEQ ID NO: 656; (32) CDR-H1 as depicted in SEQ ID NO: 661, CDR-H2 as depicted in SEQ ID NO: 662, CDR-H3 as depicted in SEQ ID NO: 663, CDR-L1 as depicted in SEQ ID NO: 664, CDR-L2 as depicted in SEQ ID NO: 665 and CDR-L3 as depicted in SEQ ID NO: 666; (33) CDR-H1 as depicted in SEQ ID NO: 671, CDR-H2 as depicted in SEQ ID NO: 672, CDR-H3 as depicted in SEQ ID NO: 673, CDR-L1 as depicted in SEQ ID NO: 674, CDR-L2 as depicted in SEQ ID NO: 675 and CDR-L3 as depicted in SEQ ID NO: 676; (34) CDR-H1 as depicted in SEQ ID NO: 681, CDR-H2 as depicted in SEQ ID NO: 682, CDR-H3 as depicted in SEQ ID NO: 683, CDR-L1 as depicted in SEQ ID NO: 684, CDR-L2 as depicted in SEQ ID NO: 685 and CDR-L3 as depicted in SEQ ID NO: 686; (35) CDR-H1 as depicted in SEQ ID NO: 691, CDR-H2 as depicted in SEQ ID NO: 692, CDR-H3 as depicted in SEQ ID NO: 693, CDR-L1 as depicted in SEQ ID NO: 694, CDR-L2 as depicted in SEQ ID NO: 695 and CDR-L3 as depicted in SEQ ID NO: 696; 189 (36) CDR-H1 as depicted in SEQ ID NO: 701, CDR-H2 as depicted in SEQ ID NO: 702, CDR-H3 as depicted in SEQ ID NO: 703, CDR-L1 as depicted in SEQ ID NO: 704, CDR-L2 as depicted in SEQ ID NO: 705 and CDR-L3 as depicted in SEQ ID NO: 706; (37) CDR-H1 as depicted in SEQ ID NO: 711, CDR-H2 as depicted in SEQ ID NO: 712, CDR-H3 as depicted in SEQ ID NO: 713, CDR-L1 as depicted in SEQ ID NO: 714, CDR-L2 as depicted in SEQ ID NO: 715 and CDR-L3 as depicted in SEQ ID NO: 716; (38) CDR-H1 as depicted in SEQ ID NO: 721, CDR-H2 as depicted in SEQ ID NO: 722, CDR-H3 as depicted in SEQ ID NO: 723, CDR-L1 as depicted in SEQ ID NO: 724, CDR-L2 as depicted in SEQ ID NO: 725 and CDR-L3 as depicted in SEQ ID NO: 726; (39) CDR-H1 as depicted in SEQ ID NO: 731, CDR-H2 as depicted in SEQ ID NO: 732, CDR-H3 as depicted in SEQ ID NO: 733, CDR-L1 as depicted in SEQ ID NO: 734, CDR-L2 as depicted in SEQ ID NO: 735 and CDR-L3 as depicted in SEQ ID NO: 736; (40) CDR-H1 as depicted in SEQ ID NO: 741, CDR-H2 as depicted in SEQ ID NO: 742, CDR-H3 as depicted in SEQ ID NO: 743, CDR-L1 as depicted in SEQ ID NO: 744, CDR-L2 as depicted in SEQ ID NO: 745 and CDR-L3 as depicted in SEQ ID NO: 746; (41) CDR-H1 as depicted in SEQ ID NO: 751, CDR-H2 as depicted in SEQ ID NO: 752, CDR-H3 as depicted in SEQ ID NO: 753, CDR-L1 as depicted in SEQ ID NO: 754, CDR-L2 as depicted in SEQ ID NO: 755 and CDR-L3 as depicted in SEQ ID NO: 756; (42) CDR-H1 as depicted in SEQ ID NO: 761, CDR-H2 as depicted in SEQ ID NO: 762, CDR-H3 as depicted in SEQ ID NO: 763, CDR-L1 as depicted in SEQ ID NO: 764, CDR-L2 as depicted in SEQ ID NO: 765 and CDR-L3 as depicted in SEQ ID NO: 766; (43) CDR-H1 as depicted in SEQ ID NO: 771, CDR-H2 as depicted in SEQ ID NO: 772, CDR-H3 as depicted in SEQ ID NO: 773, CDR-L1 as depicted in SEQ ID NO: 774, CDR-L2 as depicted in SEQ ID NO: 775 and CDR-L3 as depicted in SEQ ID NO: 776; (44) CDR-H1 as depicted in SEQ ID NO: 781, CDR-H2 as depicted in SEQ ID NO: 782, CDR-H3 as depicted in SEQ ID NO: 783, CDR-L1 as depicted in SEQ ID NO: 784, 190 CDR-L2 as depicted in SEQ ID NO: 785 and CDR-L3 as depicted in SEQ ID NO: 786; (45) CDR-H1 as depicted in SEQ ID NO: 791, CDR-H2 as depicted in SEQ ID NO: 792, CDR-H3 as depicted in SEQ ID NO: 793, CDR-L1 as depicted in SEQ ID NO: 794, CDR-L2 as depicted in SEQ ID NO: 795 and CDR-L3 as depicted in SEQ ID NO: 796; (46) CDR-H1 as depicted in SEQ ID NO: 801, CDR-H2 as depicted in SEQ ID NO: 802, CDR-H3 as depicted in SEQ ID NO: 803, CDR-L1 as depicted in SEQ ID NO: 804, CDR-L2 as depicted in SEQ ID NO: 805 and CDR-L3 as depicted in SEQ ID NO: 806; (47) CDR-H1 as depicted in SEQ ID NO: 811, CDR-H2 as depicted in SEQ ID NO: 812, CDR-H3 as depicted in SEQ ID NO: 813, CDR-L1 as depicted in SEQ ID NO: 814, CDR-L2 as depicted in SEQ ID NO: 815 and CDR-L3 as depicted in SEQ ID NO: 816; (48) CDR-H1 as depicted in SEQ ID NO: 821, CDR-H2 as depicted in SEQ ID NO: 822, CDR-H3 as depicted in SEQ ID NO: 823, CDR-L1 as depicted in SEQ ID NO: 824, CDR-L2 as depicted in SEQ ID NO: 825 and CDR-L3 as depicted in SEQ ID NO: 826; (49) CDR-H1 as depicted in SEQ ID NO: 831, CDR-H2 as depicted in SEQ ID NO: 832, CDR-H3 as depicted in SEQ ID NO: 833, CDR-L1 as depicted in SEQ ID NO: 834, CDR-L2 as depicted in SEQ ID NO: 835 and CDR-L3 as depicted in SEQ ID NO: 836; (50) CDR-H1 as depicted in SEQ ID NO: 961, CDR-H2 as depicted in SEQ ID NO: 962, CDR-H3 as depicted in SEQ ID NO: 963, CDR-L1 as depicted in SEQ ID NO: 964, CDR-L2 as depicted in SEQ ID NO: 965 and CDR-L3 as depicted in SEQ ID NO: 966; (51) CDR-H1 as depicted in SEQ ID NO: 971, CDR-H2 as depicted in SEQ ID NO: 972, CDR-H3 as depicted in SEQ ID NO: 973, CDR-L1 as depicted in SEQ ID NO: 974, CDR-L2 as depicted in SEQ ID NO: 975 and CDR-L3 as depicted in SEQ ID NO: 976; (52) CDR-H1 as depicted in SEQ ID NO: 981, CDR-H2 as depicted in SEQ ID NO: 982, CDR-H3 as depicted in SEQ ID NO: 983, CDR-L1 as depicted in SEQ ID NO: 984, CDR-L2 as depicted in SEQ ID NO: 985 and CDR-L3 as depicted in SEQ ID NO: 986; and 191 (53) CDR-H1 as depicted in SEQ ID NO: 991, CDR-H2 as depicted in SEQ ID NO: 992, CDR-H3 as depicted in SEQ ID NO: 993, CDR-L1 as depicted in SEQ ID NO: 994, CDR-L2 as depicted in SEQ ID NO: 995 and CDR-L3 as depicted in SEQ ID NO: 996.

8. The binding molecule according to any one of the preceding claims, wherein the first binding domain comprises a VH region selected from the group consisting of VH regions as depicted in SEQ ID NO: 7, SEQ ID NO: 17, SEQ ID NO: 27, SEQ ID NO: 37, SEQ ID NO: 47, SEQ ID NO: 57, SEQ ID NO: 67, SEQ ID NO: 77, SEQ ID NO: 167, SEQ ID NO: 177, SEQ ID NO: 187, SEQ ID NO: 197, SEQ ID NO: 207, SEQ ID NO: 217, SEQ ID NO: 227, SEQ ID NO: 317, SEQ ID NO: 327, SEQ ID NO: 337, SEQ ID NO: 347, SEQ ID NO: 357, SEQ ID NO: 367, SEQ ID NO: 377, SEQ ID NO: 387, SEQ ID NO: 587, SEQ ID NO: 597, SEQ ID NO: 607, SEQ ID NO: 617, SEQ ID NO: 627, SEQ ID NO: 637, SEQ ID NO: 647, SEQ ID NO: 657, SEQ ID NO: 667, SEQ ID NO: 677, SEQ ID NO: 687, SEQ ID NO: 697, SEQ ID NO: 707, SEQ ID NO: 717, SEQ ID NO: 727, SEQ ID NO: 737, SEQ ID NO: 747, SEQ ID NO: 757, SEQ ID NO: 767, SEQ ID NO: 777, SEQ ID NO: 787, SEQ ID NO: 797, SEQ ID NO: 807, SEQ ID NO: 817, SEQ ID NO: 827, SEQ ID NO: 837, SEQ ID NO: 967, SEQ ID NO: 977, SEQ ID NO: 987, and SEQ ID NO: 997.

9. The binding molecule according to any one of the preceding claims, wherein the first binding domain comprises a VL region selected from the group consisting of VL regions as depicted in SEQ ID NO: 8, SEQ ID NO: 18, SEQ ID NO: 28, SEQ ID NO: 38, SEQ ID NO: 48, SEQ ID NO: 58, SEQ ID NO: 68, SEQ ID NO: 78, SEQ ID NO: 168, SEQ ID NO: 178, SEQ ID NO: 188, SEQ ID NO: 198, SEQ ID NO: 208, SEQ ID NO: 218, SEQ ID NO: 228, SEQ ID NO: 318, SEQ ID NO: 328, SEQ ID NO: 338, SEQ ID NO: 348, SEQ ID NO: 358, SEQ ID NO: 368, SEQ ID NO: 378, SEQ ID NO: 388, SEQ ID NO: 588, SEQ ID NO: 598, SEQ ID NO: 608, SEQ ID NO: 618, SEQ ID NO: 628, SEQ ID NO: 638, SEQ ID NO: 648, SEQ ID NO: 658, SEQ ID NO: 668, SEQ ID NO: 678, SEQ ID NO: 688, SEQ ID NO: 698, SEQ ID NO: 708, SEQ ID NO: 718, SEQ ID NO: 728, SEQ ID NO: 738, SEQ ID NO: 748, SEQ ID NO: 758, SEQ ID NO: 768, SEQ ID NO: 778, SEQ ID NO: 788, SEQ ID NO: 798, SEQ ID NO: 808, SEQ ID NO: 818, SEQ ID NO: 828, SEQ ID NO: 838, SEQ ID NO: 968, SEQ ID NO: 978, SEQ ID NO: 988, and SEQ ID NO: 998. 192

10. The binding molecule according to any one of the preceding claims, wherein the first binding domain comprises a VH region and a VL region selected from the group consisting of: (1) a VH region as depicted in SEQ ID NO: 7, and a VL region as depicted in SEQ ID NO: 8; (2) a VH region as depicted in SEQ ID NO: 17, and a VL region as depicted in SEQ ID NO: 18; (3) a VH region as depicted in SEQ ID NO: 27, and a VL region as depicted in SEQ ID NO: 28; (4) a VH region as depicted in SEQ ID NO: 37, and a VL region as depicted in SEQ ID NO: 38; (5) a VH region as depicted in SEQ ID NO: 47, and a VL region as depicted in SEQ ID NO: 48; (6) a VH region as depicted in SEQ ID NO: 57, and a VL region as depicted in SEQ ID NO: 58; (7) a VH region as depicted in SEQ ID NO: 67, and a VL region as depicted in SEQ ID NO: 68; (8) a VH region as depicted in SEQ ID NO: 77, and a VL region as depicted in SEQ ID NO: 78; (9) a VH region as depicted in SEQ ID NO: 167, and a VL region as depicted in SEQ ID NO: 168; (10) a VH region as depicted in SEQ ID NO: 177, and a VL region as depicted in SEQ ID NO: 178; (11) a VH region as depicted in SEQ ID NO: 187, and a VL region as depicted in SEQ ID NO: 188; (12) a VH region as depicted in SEQ ID NO: 197, and a VL region as depicted in SEQ ID NO: 198; (13) a VH region as depicted in SEQ ID NO: 207, and a VL region as depicted in SEQ ID NO: 208; (14) a VH region as depicted in SEQ ID NO: 217, and a VL region as depicted in SEQ ID NO: 218; (15) a VH region as depicted in SEQ ID NO: 227, and a VL region as depicted in SEQ ID NO: 228; (16) a VH region as depicted in SEQ ID NO: 317, and a VL region as depicted in SEQ ID NO: 318; 193 (17) a VH region as depicted in SEQ ID NO: 327, and a VL region as depicted in SEQ ID NO: 328; (18) a VH region as depicted in SEQ ID NO: 337, and a VL region as depicted in SEQ ID NO: 338; (19) a VH region as depicted in SEQ ID NO: 347, and a VL region as depicted in SEQ ID NO: 348; (20) a VH region as depicted in SEQ ID NO: 357, and a VL region as depicted in SEQ ID NO: 358; (21) a VH region as depicted in SEQ ID NO: 367, and a VL region as depicted in SEQ ID NO: 368; (22) a VH region as depicted in SEQ ID NO: 377, and a VL region as depicted in SEQ ID NO: 378; (23) a VH region as depicted in SEQ ID NO: 387, and a VL region as depicted in SEQ ID NO: 388; (24) a VH region as depicted in SEQ ID NO: 587, and a VL region as depicted in SEQ ID NO: 588; (25) a VH region as depicted in SEQ ID NO: 597, and a VL region as depicted in SEQ ID NO: 598; (26) a VH region as depicted in SEQ ID NO: 607, and a VL region as depicted in SEQ ID NO: 608; (27) a VH region as depicted in SEQ ID NO: 617, and a VL region as depicted in SEQ ID NO: 618; (28) a VH region as depicted in SEQ ID NO: 627, and a VL region as depicted in SEQ ID NO: 628; (29) a VH region as depicted in SEQ ID NO: 637, and a VL region as depicted in SEQ ID NO: 638; (30) a VH region as depicted in SEQ ID NO: 647, and a VL region as depicted in SEQ ID NO: 648; (31) a VH region as depicted in SEQ ID NO: 657, and a VL region as depicted in SEQ ID NO: 658; (32) a VH region as depicted in SEQ ID NO: 667, and a VL region as depicted in SEQ ID NO: 668; (33) a VH region as depicted in SEQ ID NO: 677, and a VL region as depicted in SEQ ID NO: 678; 194 (34) a VH region as depicted in SEQ ID NO: 687, and a VL region as depicted in SEQ ID NO: 688; (35) a VH region as depicted in SEQ ID NO: 697, and a VL region as depicted in SEQ ID NO: 698; (36) a VH region as depicted in SEQ ID NO: 707, and a VL region as depicted in SEQ ID NO: 708; (37) a VH region as depicted in SEQ ID NO: 717, and a VL region as depicted in SEQ ID NO: 718; (38) a VH region as depicted in SEQ ID NO: 727, and a VL region as depicted in SEQ ID NO: 728; (39) a VH region as depicted in SEQ ID NO: 737, and a VL region as depicted in SEQ ID NO: 738; (40) a VH region as depicted in SEQ ID NO: 747, and a VL region as depicted in SEQ ID NO: 748; (41) a VH region as depicted in SEQ ID NO: 757, and a VL region as depicted in SEQ ID NO: 758; (42) a VH region as depicted in SEQ ID NO: 767, and a VL region as depicted in SEQ ID NO: 768; (43) a VH region as depicted in SEQ ID NO: 777, and a VL region as depicted in SEQ ID NO: 778; (44) a VH region as depicted in SEQ ID NO: 787, and a VL region as depicted in SEQ ID NO: 788; (45) a VH region as depicted in SEQ ID NO: 797, and a VL region as depicted in SEQ ID NO: 798; (46) a VH region as depicted in SEQ ID NO: 807, and a VL region as depicted in SEQ ID NO: 808; (47) a VH region as depicted in SEQ ID NO: 817, and a VL region as depicted in SEQ ID NO: 818; (48) a VH region as depicted in SEQ ID NO: 827, and a VL region as depicted in SEQ ID NO: 828; (49) a VH region as depicted in SEQ ID NO: 837, and a VL region as depicted in SEQ ID NO: 838; (50) a VH region as depicted in SEQ ID NO: 967, and a VL region as depicted in SEQ ID NO: 968; 195 (51) a VH region as depicted in SEQ ID NO: 977, and a VL region as depicted in SEQ ID NO: 978; (52) a VH region as depicted in SEQ ID NO: 987, and a VL region as depicted in SEQ ID NO: 988; and (53) a VH region as depicted in SEQ ID NO: 997, and a VL region as depicted in SEQ ID NO: 998.

11. The binding molecule according to claim 10, wherein the first binding domain comprises an amino acid sequence selected from the group consisting of SEQ ID NO: 9, SEQ ID NO: 19, SEQ ID NO: 29, SEQ ID NO: 39, SEQ ID NO: 49, SEQ ID NO: 59, SEQ ID NO: 69, SEQ ID NO: 79, SEQ ID NO: 169, SEQ ID NO: 179, SEQ ID NO: 189, SEQ ID NO: 199, SEQ ID NO: 209, SEQ ID NO: 219, SEQ ID NO: 229, SEQ ID NO: 319, SEQ ID NO: 329, SEQ ID NO: 339, SEQ ID NO: 349, SEQ ID NO: 359, SEQ ID NO: 369, SEQ ID NO: 379, SEQ ID NO: 389, SEQ ID NO: 589, SEQ ID NO: 599, SEQ ID NO: 609, SEQ ID NO: 619, SEQ ID NO: 629, SEQ ID NO: 639, SEQ ID NO: 649, SEQ ID NO: 659, SEQ ID NO: 669, SEQ ID NO: 679, SEQ ID NO: 689, SEQ ID NO: 699, SEQ ID NO: 709, SEQ ID NO: 719, SEQ ID NO: 729, SEQ ID NO: 739, SEQ ID NO: 749, SEQ ID NO: 759, SEQ ID NO: 769, SEQ ID NO: 779, SEQ ID NO: 789, SEQ ID NO: 799, SEQ ID NO: 809, SEQ ID NO: 819, SEQ ID NO: 829, SEQ ID NO: 839, SEQ ID NO: 969, SEQ ID NO: 979, SEQ ID NO: 989, and SEQ ID NO: 999.

12. The binding molecule according to any one of claims 1-6 having the amino acid sequence shown in SEQ ID NO:340 or SEQ ID NO: 980.

13. The binding molecule according to any one of the preceding claims, characterized by an EC50 (pg/ml) of 350 or less, preferably 320 or less.

14. The binding molecule according to any one of the preceding claims, characterized by an EC50 (pg/mI) which equates to the EC50 (pg/ml) of any one of BC E5 33-B1 1-B8, BC 5G9 92-E10, BC 5G9 91-D2-B10, BC B12 33-A4-B2, BC 3A4 37-Al 1-G1, BC A7-27 C4 G7, BC C3 33-D7-B1, BC C3 33-F8-E6 B1.

15. A nucleic acid sequence encoding a binding molecule as defined in any one of claims 1 to 14 196

16. A vector comprising a nucleic acid sequence as defined in claim 15.

17. A host cell transformed or transfected with the nucleic acid sequence as defined in claim 15 or with the vector as defined in claim 16.

18. A process for the production of a binding molecule according to any one of claims 1 to 14, said process comprising culturing a host cell as defined in claim 17 under conditions allowing the expression of the binding molecule as defined in any one of claims 1 to 14 and recovering the produced binding molecule from the culture.

19. A pharmaceutical composition comprising a binding molecule according to any one of claims 1 to 14, or produced according to the process of claim 18.

20. The binding molecule according to any one of claims 1 to 14, or produced according to the process of claim 18 for use in the prevention, treatment or amelioration of a disease selected from the group consisting of plasma cell disorders, other B cell disorders that correlate with BCMA expression and autoimmune diseases.

21. A method for the treatment or amelioration of a disease selected from the group consisting of plasma cell disorders, other B cell disorders that correlate with BCMA expression and autoimmune diseases, comprising the step of administering to a subject in need thereof the binding molecule according to any one of claims 1 to 14, or produced according to the process of claim 18.

22. The method according to claim 21, wherein the plasma cell disorder is selected from the group consisting of multiple myeloma, plasmacytoma, plasma cell leukemia, macro globulinemia, amyloidosis, Waldenstrom's macroglobulinemia , solitary bone plasma cytoma, extramedullary plasmacytoma, osteosclerotic myeloma, heavy chain diseases, monoclonal gammopathy of undetermined significance, and smoldering multiple myeloma.

23. The method according to claim 21, wherein the autoimmune disease is systemic lupus erythematodes. 197

24. A kit comprising a binding molecule as defined in any one of claims 1 to 14, a nucleic acid molecule as defined in claim 15, a vector as defined in claim 16, and/or a host cell as defined in claim 17.

25. Use of epitope cluster 3 of BCMA for the generation of a binding molecule, preferably an antibody, which is capable of binding to BCMA, wherein epitope cluster 3 of BCMA corresponds to amino acid residues 24 to 41 of the sequence as depicted in SEQ ID NO: 1002.

26. A method for the generation of an antibody, preferably a bispecific binding molecule, which is capable of binding to BCMA, comprising (a) immunizing an animal with a polypeptide comprising epitope cluster 3 of BCMA, wherein epitope cluster 3 of BCMA corresponds to amino acid residues 24 to 41 of the sequence as depicted in SEQ ID NO: 1002, (b) obtaining said antibody, and (c) optionally converting said antibody into a bispecific binding molecule which is capable of binding to human BCMA and preferably to the T cell CD3 receptor complex. 198