AU2012324721A1 - Improvements to silicon nuclear implants - Google Patents

Improvements to silicon nuclear implants Download PDF

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Publication number
AU2012324721A1
AU2012324721A1 AU2012324721A AU2012324721A AU2012324721A1 AU 2012324721 A1 AU2012324721 A1 AU 2012324721A1 AU 2012324721 A AU2012324721 A AU 2012324721A AU 2012324721 A AU2012324721 A AU 2012324721A AU 2012324721 A1 AU2012324721 A1 AU 2012324721A1
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AU
Australia
Prior art keywords
core
nucleus
implant
vertebra
extensions
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Granted
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AU2012324721A
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AU2012324721B2 (en
Inventor
Adrien BILLON
Jean Yves Leroy
Alain Tornier
Guy Viart
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Clariance SAS
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Clariance SAS
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Publication of AU2012324721B2 publication Critical patent/AU2012324721B2/en
Ceased legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/441—Joints for the spine, e.g. vertebrae, spinal discs made of inflatable pockets or chambers filled with fluid, e.g. with hydrogel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238—Type of minimally invasive operation
    • A61B2017/00261—Discectomy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30065—Properties of materials and coating materials thermoplastic, i.e. softening or fusing when heated, and hardening and becoming rigid again when cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30069—Properties of materials and coating materials elastomeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30537—Special structural features of bone or joint prostheses not otherwise provided for adjustable
    • A61F2002/30548—Special structural features of bone or joint prostheses not otherwise provided for adjustable for adjusting fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30563—Special structural features of bone or joint prostheses not otherwise provided for having elastic means or damping means, different from springs, e.g. including an elastomeric core or shock absorbers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535—Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30581—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid
    • A61F2002/30583—Special structural features of bone or joint prostheses not otherwise provided for having a pocket filled with fluid, e.g. liquid filled with hardenable fluid, e.g. curable in-situ
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
    • A61F2002/30878—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
    • A61F2002/444—Intervertebral or spinal discs, e.g. resilient for replacing the nucleus pulposus

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The nuclear implant according to the present invention consists of a nucleus (10) arranged inside a nuclear space (Es) obtained after nucleotomy of the intervertebral disc (Di) and at least one extension (11) penetrating inside at least one channel (Co) formed in the vertebral body of the corresponding vertebra (Va, Vb) to strengthen and provide a link between the nuclear implant (1) and the bone body of the vertebra (Va) and/or (Vb), by diffusion or migration of the viscoelastic material forming said nuclear implant into the cancellous bone of said vertebra.

Description

1 Improved silicone nucleus implants 5 The present invention relates to a silicone nucleus implant, arranged between a superjacent vertebra and an underlying vertebra of a spinal segment, constituting an intervertebral bracing device that absorbs shocks and ensures the mobility of the functional unit formed by said vertebrae. 10 The deterioration of the nucleus is generally the first factor that leads to deterioration of the disk, and consequently of the joint facets. This deterioration can cause hernias, and this problem is often treated by nucleotomy. However, although the pain disappears in immediate post-op, the loss of height of 15 the disk and the hyper-mobility of the consecutive segment gradually accentuate the deterioration of the spinal segment, with pain reappearing and sometimes with deterioration of the adjacent stages. Early nucleus replacement for such patients may be an effective alternative to 20 total replacement of the disk or fusion of the segment. In fact, maintaining a sufficient intervertebral height with quasi-normal mobility may impart a certain degree of stability to the segment, thereby slowing or even stopping deterioration phenomena. 25 Known from international patent application WO 2009/130417, belonging to the applicant, is a nucleus implant having at least one filling element having at least one continuous filament which is arranged inside a nucleus pulposus space obtained after nucleotomy of the intervertebral disk, and which follows a ring 30 shaped profile, and of which the stack of spirals delimits a central inner space that is filled with a product such as a gel or paste, a fiber-based product, or an injectable viscoelastic material. It will be noted that this type of implant has problems with gradually migrating 35 toward the medullary channel during repeated extension flexion movements of said vertebrae of the spinal segment, since the implant is not connected or attached to the body of the corresponding vertebrae. The nucleus implant according to the present invention aims to improve the 40 nucleus implant by reducing the number of components it includes and guaranteeing a stable and effective connection between the implant and the vertebral bodies of the concerned spinal segment. The nucleus implant according to the present invention consists of a core 45 arranged inside a nucleus pulposus space obtained after nucleotomy of the 2 intervertebral disk and at least one extension penetrating inside at least one channel formed in the vertebral body of the corresponding vertebra to strengthen and ensure a connection between the nucleus implant and the bone body of the vertebra through the diffusion or migration of the viscoelastic material making up 5 said nucleus implant in the cancellous bone. The nucleus implant according to the present invention has a core comprising at least two extensions that extend on either side of the center of said core. 10 The nucleus implant according to the present invention has a core and extensions that are obtained from a fluid or organosiloxane-based paste composition, autopolymerizing at ambient temperature in permanently elastic silicone. The nucleus implant according to the present invention has a core and extensions 15 that are obtained from a polydimethylsiloxane-based composition. The nucleus implant according to the present invention has a core and extensions that are obtained from a composition containing platinum catalyst. 20 The nucleus implant according to the present invention has a core and extensions that are obtained from a composition containing a catalyst with a base of hydride functionalized siloxane and vinyl-functionalized siloxane. The following description, done in reference to the appended drawings, provided 25 as non-limiting examples, will make it possible to better understand the invention, the features thereof, and the advantages it may procure: Figure 1 is an exploded perspective view illustrating the nucleus implant according to the present invention, the core of which is obtained by injecting a silicone-based 30 material. Figure 2 is a cross-sectional view illustrating the nucleus implant according to the present invention, the core of which is obtained by injecting a silicone-based material. 35 Figure 3 is a perspective view diagrammatically illustrating the nucleus implant, the core of which for example has at least two cords extending on either side of the center of said core according to the present invention. 40 Figures 1 and 2 show a spinal segment Sr of a vertebral column whereof at least one of the superjacent Va and underlying Vb vertebrae will be pierced using a drilling device (not shown) with at least one bone channel having a curved profile Co so as to reach the upper surface of a damaged intervertebral disk Di. 45 Drilling the superjacent vertebra Va with a curved profile, for example, makes it possible to use a transosseous percutaneous surgical approach to reach the 3 nucleus of the intervertebral disk Di so as then to be able to perform the necessary operations on the damaged intervertebral disk until a nucleus pulposus space Es is obtained at the center of the "annulus fibrosis" AF. 5 The drilling of the superjacent Va and/or underlying Vb vertebrae with a curved profile is for example done using a drilling device described and protected in patent application FR1 1/00199, belonging to the applicant. When the bone channel with the curved profile Co is obtained, it allows the 10 insertion, using an injection device (not shown), of a viscoelastic material that autopolymerizes at ambient temperature, making it possible to produce a nucleus implant 1 inside the nucleic pulposus space Es. The nucleus implant 1 is made from silicone or a viscoelastic material that 15 autopolymerizes at ambient temperature. The nucleus implant 1 is made up of a core 10 having at least one extension 11 penetrating inside the channel(s) with a curved profile Co formed in the vertebral body of the corresponding vertebra. Each extension 11 extending from the core 10 makes it possible to provide a 20 connection between said core and the bone body of the corresponding vertebra Va and/or Vb, preventing any possibility of the nucleus implant 1 migrating relative to the "annulus fibrosis" AF and said vertebrae. Each extension 11 makes it possible to strengthen and ensure a connection 25 between the nucleus implant 1 and the bone body of the vertebra Va/Vb through the diffusion or migration of the viscoelastic material that autopolymerizes at ambient temperature in the cancellous bone of said vertebral body of the corresponding vertebra Va, Vb. 30 In fact, the connection produced by the extensions 11 makes it possible to keep the nucleus implant 1 in place between the vertebrae Va and/or Vb and thereby prevents the gradual migration of the latter toward the medullary channel during repeated extension flexion movements of said vertebrae Va and/or Vb of the spinal segment Sr. 35 Each extension 11 of the nucleus implant 1 also makes it possible to obstruct the corresponding curved bone channel Co to prevent any possibility of foreign body migration inside the intervertebral disk Di. 40 The nucleus implant 1 made up of the core 10 and the extensions 11 can be obtained from a fluid or organosiloxane-based paste composition autopolymerizing at ambient temperature in permanently elastic silicone.
4 The nucleus implant 1 made up of the core 10 and extensions 11 is obtained from a fluid or organosiloxane-based paste composition of the polydimethylsiloxane type autopolymerizing at ambient temperature in permanently elastic silicone. 5 The nucleus implant 1 made up of the core 10 and extensions 11 is obtained from a fluid or organosiloxane-based paste composition that may be of the polydimethylsiloxane type autopolymerizing at ambient temperature in permanently elastic silicone and containing platinum catalyst. 10 The nucleus implant 1 made up of the core 10 and extensions 11 is obtained from a fluid or organosiloxane-based paste composition that may be of the polydimethylsiloxane type autopolymerizing at ambient temperature in permanently elastic silicone and containing a catalyst with a base of hydride functionalized siloxane and vinyl-functionalized siloxane. 15 It must also be understood that the preceding description has been provided solely as an example and in no way limits the scope of the invention, and it would not go beyond the scope of the invention to replace the described details of the embodiments with any equivalent means. 20

Claims (6)

1. A nucleus implant arranged between a superjacent vertebra (Va) and an 5 underlying vertebra (Vb) of a spinal segment (Sr), constituting an intervertebral bracing device that absorbs shocks and ensures the mobility of the functional unit formed by said vertebrae, characterized in that it consists of a core (10) arranged inside a nucleus pulposus space (Es) obtained after nucleotomy of the intervertebral disk (Di) and at least one extension (11) penetrating inside at 10 least one channel (Co) formed in the vertebral body of the corresponding vertebra (Va, Vb) to strengthen and ensure a connection between the nucleus implant (1) and the bone body of the vertebra (Va) and/or (Vb) through the diffusion or migration of the viscoelastic material making up said nucleus implant in the cancellous bone of said vertebra. 15
2. The nucleus implant according to claim 1, characterized in that the core (10) comprises at least two extensions (11) that extend on either side of the center of said core. 20
3. The nucleus implant according to claim 2, characterized in that the core (10) and extensions (11) of said implant are obtained from a fluid or organosiloxane-based paste composition, autopolymerizing at ambient temperature in permanently elastic silicone. 25
4. The nucleus implant according to claim 3, characterized in that the core (10) and extensions (11) of said implant are obtained from a polydimethylsiloxane based composition.
5. The nucleus implant according to one of claims 3 and 4, characterized in that 30 the core (10) and extensions (11) of said implant are obtained from a composition containing platinum catalyst.
6. The nucleus implant according to one of claims 2 and 3, characterized in that the core (10) and extensions (11) of said implant are obtained from a 35 composition containing a catalyst with a base of hydride-functionalized siloxane and vinyl-functionalized siloxane.
AU2012324721A 2011-10-17 2012-10-05 Improvements to silicon nuclear implants Ceased AU2012324721B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR1159341 2011-10-17
FR1159341A FR2981263B1 (en) 2011-10-17 2011-10-17 IMPROVEMENTS TO NUCLEIC SILICONE IMPLANTS
PCT/FR2012/052258 WO2013057409A1 (en) 2011-10-17 2012-10-05 Improvements to silicon nuclear implants

Publications (2)

Publication Number Publication Date
AU2012324721A1 true AU2012324721A1 (en) 2014-04-24
AU2012324721B2 AU2012324721B2 (en) 2016-09-22

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AU2012324721A Ceased AU2012324721B2 (en) 2011-10-17 2012-10-05 Improvements to silicon nuclear implants

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EP (1) EP2768433B1 (en)
JP (1) JP2014531963A (en)
KR (1) KR20140090982A (en)
CN (1) CN103917195B (en)
AU (1) AU2012324721B2 (en)
BR (1) BR112014009167A2 (en)
ES (1) ES2602165T3 (en)
FR (1) FR2981263B1 (en)
WO (1) WO2013057409A1 (en)

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BR112014006615A2 (en) * 2011-09-20 2017-04-04 Abbott Lab nutritional powder formulations including spray dried vegetable protein

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FR1100199A (en) 1954-05-24 1955-09-16 Microcell Ltd Improvements to plastics and applications of these improvements
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US6264695B1 (en) * 1999-09-30 2001-07-24 Replication Medical, Inc. Spinal nucleus implant
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WO2005041793A2 (en) * 2003-10-23 2005-05-12 Trans1, Inc. Spinal mobility preservation apparatus and method
JP2008508980A (en) * 2004-08-09 2008-03-27 トランス１，インク． Nucleus nucleus prosthesis device and method
US20060253198A1 (en) * 2005-05-03 2006-11-09 Disc Dynamics, Inc. Multi-lumen mold for intervertebral prosthesis and method of using same
US7547319B2 (en) * 2005-06-15 2009-06-16 Ouroboros Medical Mechanical apparatus and method for artificial disc replacement
CN101304709A (en) * 2005-08-15 2008-11-12 蒂斯科动力学公司 Multi-lumen mold for intervertebral prosthesis and method of using same
CN101130106B (en) * 2007-09-28 2010-06-02 清华大学 Method of producing artificial prosthesis of disci intervertebrales nucleus pulposus
WO2009070607A1 (en) * 2007-11-27 2009-06-04 Transcorp, Inc. Methods and systems for repairing an intervertebral disc using a transcorporal approach
FR2929502B1 (en) * 2008-04-04 2011-04-08 Clariance NUCLEIC IMPLANT.
WO2010077359A1 (en) * 2008-12-30 2010-07-08 Mitchell Hardenbrook Expandable interbody implant and method

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Publication number Publication date
JP2014531963A (en) 2014-12-04
CN103917195A (en) 2014-07-09
FR2981263A1 (en) 2013-04-19
ES2602165T3 (en) 2017-02-17
BR112014009167A2 (en) 2017-04-11
EP2768433B1 (en) 2016-08-10
KR20140090982A (en) 2014-07-18
AU2012324721B2 (en) 2016-09-22
FR2981263B1 (en) 2013-11-15
CN103917195B (en) 2016-12-28
WO2013057409A1 (en) 2013-04-25
EP2768433A1 (en) 2014-08-27

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