AU2012267620B2 - Pressurized Vessel of Nitric Oxide (NO) - Google Patents
Pressurized Vessel of Nitric Oxide (NO) Download PDFInfo
- Publication number
- AU2012267620B2 AU2012267620B2 AU2012267620A AU2012267620A AU2012267620B2 AU 2012267620 B2 AU2012267620 B2 AU 2012267620B2 AU 2012267620 A AU2012267620 A AU 2012267620A AU 2012267620 A AU2012267620 A AU 2012267620A AU 2012267620 B2 AU2012267620 B2 AU 2012267620B2
- Authority
- AU
- Australia
- Prior art keywords
- nitric oxide
- gas flow
- gas
- delivery system
- pressure vessel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 403
- 239000007789 gas Substances 0.000 claims description 273
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 104
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 claims description 93
- 238000000034 method Methods 0.000 claims description 60
- 239000011261 inert gas Substances 0.000 claims description 55
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 51
- 239000003638 chemical reducing agent Substances 0.000 claims description 38
- 229910052757 nitrogen Inorganic materials 0.000 claims description 21
- 239000011149 active material Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 18
- 238000010438 heat treatment Methods 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 12
- 230000001105 regulatory effect Effects 0.000 claims description 10
- 241000124008 Mammalia Species 0.000 claims description 6
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 10
- 229940127557 pharmaceutical product Drugs 0.000 abstract description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 27
- 239000003963 antioxidant agent Substances 0.000 description 16
- 230000003078 antioxidant effect Effects 0.000 description 16
- 235000006708 antioxidants Nutrition 0.000 description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 235000010323 ascorbic acid Nutrition 0.000 description 12
- 239000011668 ascorbic acid Substances 0.000 description 12
- 229960005070 ascorbic acid Drugs 0.000 description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 12
- 239000001301 oxygen Substances 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 239000000741 silica gel Substances 0.000 description 11
- 229910002027 silica gel Inorganic materials 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 8
- WFPZPJSADLPSON-UHFFFAOYSA-N dinitrogen tetraoxide Chemical compound [O-][N+](=O)[N+]([O-])=O WFPZPJSADLPSON-UHFFFAOYSA-N 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000012047 saturated solution Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
- -1 Fe(II) Chemical class 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 229910001873 dinitrogen Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002664 inhalation therapy Methods 0.000 description 3
- 230000004962 physiological condition Effects 0.000 description 3
- 208000002815 pulmonary hypertension Diseases 0.000 description 3
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 description 2
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 2
- 108010024636 Glutathione Proteins 0.000 description 2
- 206010021143 Hypoxia Diseases 0.000 description 2
- 208000010378 Pulmonary Embolism Diseases 0.000 description 2
- 229910018503 SF6 Inorganic materials 0.000 description 2
- 229940087168 alpha tocopherol Drugs 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- BFGKITSFLPAWGI-UHFFFAOYSA-N chromium(3+) Chemical compound [Cr+3] BFGKITSFLPAWGI-UHFFFAOYSA-N 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 235000010382 gamma-tocopherol Nutrition 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 230000008570 general process Effects 0.000 description 2
- 239000011491 glass wool Substances 0.000 description 2
- 229960003180 glutathione Drugs 0.000 description 2
- 239000001307 helium Substances 0.000 description 2
- 229910052734 helium Inorganic materials 0.000 description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
- 230000007954 hypoxia Effects 0.000 description 2
- 229910052743 krypton Inorganic materials 0.000 description 2
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052754 neon Inorganic materials 0.000 description 2
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 229910052704 radon Inorganic materials 0.000 description 2
- SYUHGPGVQRZVTB-UHFFFAOYSA-N radon atom Chemical compound [Rn] SYUHGPGVQRZVTB-UHFFFAOYSA-N 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 2
- 229960000909 sulfur hexafluoride Drugs 0.000 description 2
- 150000003573 thiols Chemical class 0.000 description 2
- 229960000984 tocofersolan Drugs 0.000 description 2
- 229910052724 xenon Inorganic materials 0.000 description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 2
- 235000004835 α-tocopherol Nutrition 0.000 description 2
- 239000002076 α-tocopherol Substances 0.000 description 2
- 239000002478 γ-tocopherol Substances 0.000 description 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010001029 Acute pulmonary oedema Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 206010003504 Aspiration Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 208000003241 Fat Embolism Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000034388 Mountain sickness acute Diseases 0.000 description 1
- 101100400378 Mus musculus Marveld2 gene Proteins 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-N Nitrous acid Chemical compound ON=O IOVCWXUNBOPUCH-UHFFFAOYSA-N 0.000 description 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000005279 Status Asthmaticus Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 208000018315 acute mountain sickness Diseases 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000779 depleting effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229940042110 inomax Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940010287 nitric oxide / nitrogen Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 201000008312 primary pulmonary hypertension Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940048914 protamine Drugs 0.000 description 1
- 230000008695 pulmonary vasoconstriction Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2016204447A AU2016204447C1 (en) | 2011-06-10 | 2016-06-28 | Pressurized Vessel Of Nitric Oxide (NO) |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161495950P | 2011-06-10 | 2011-06-10 | |
| US61/495,950 | 2011-06-10 | ||
| PCT/US2012/041593 WO2012170843A1 (en) | 2011-06-10 | 2012-06-08 | Pressurized vessel of nitric oxide (no) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016204447A Division AU2016204447C1 (en) | 2011-06-10 | 2016-06-28 | Pressurized Vessel Of Nitric Oxide (NO) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012267620A1 AU2012267620A1 (en) | 2014-01-09 |
| AU2012267620B2 true AU2012267620B2 (en) | 2016-07-07 |
Family
ID=47296480
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012267620A Ceased AU2012267620B2 (en) | 2011-06-10 | 2012-06-08 | Pressurized Vessel of Nitric Oxide (NO) |
| AU2016204447A Ceased AU2016204447C1 (en) | 2011-06-10 | 2016-06-28 | Pressurized Vessel Of Nitric Oxide (NO) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016204447A Ceased AU2016204447C1 (en) | 2011-06-10 | 2016-06-28 | Pressurized Vessel Of Nitric Oxide (NO) |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP3391891A3 (enExample) |
| JP (2) | JP2014520113A (enExample) |
| AU (2) | AU2012267620B2 (enExample) |
| CA (1) | CA2838829A1 (enExample) |
| WO (1) | WO2012170843A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2890202A1 (en) * | 2012-11-05 | 2014-05-08 | Geno Llc | Method of mixing gases including nitric oxide |
| JP6041387B2 (ja) | 2013-03-27 | 2016-12-07 | 住友精化株式会社 | 一酸化窒素の品質維持方法 |
| US20210386944A1 (en) * | 2018-10-12 | 2021-12-16 | Sanotize Research Development Corp. | Gas-evolving compositions and container and delivery systems |
| JP6667817B1 (ja) * | 2019-03-13 | 2020-03-18 | 住友精化株式会社 | ガス組成物及びその製造方法、並びにガス製品 |
| EP4200003A4 (en) * | 2020-08-20 | 2025-01-01 | The UAB Research Foundation | NITRIC OXIDE GENERATION AND DELIVERY SYSTEMS |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003186A1 (en) * | 1996-07-18 | 1998-01-29 | Sumitomo Seika Chemicals Co., Ltd. | Mixed nitrogen monoxide gas for medical applications and process for preparing the same |
| US6109260A (en) * | 1998-02-18 | 2000-08-29 | Datex-Ohmeda, Inc. | Nitric oxide administration device with timed pulse |
| US6749834B2 (en) * | 2001-06-19 | 2004-06-15 | World Precision Instruments, Inc. | Methods and apparatus for therapeutic treatment of respiratory, cardiac and other pathologies |
| US20060180147A1 (en) * | 2004-08-18 | 2006-08-17 | Cyterra Corporation | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US20070104653A1 (en) * | 2004-05-11 | 2007-05-10 | Miller Christopher C | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5426194B2 (enExample) * | 1973-09-03 | 1979-09-03 | ||
| US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| JP3986722B2 (ja) * | 2000-01-31 | 2007-10-03 | 帝人株式会社 | 呼吸用気体供給装置 |
| US6345730B1 (en) * | 2000-06-13 | 2002-02-12 | Mallinckrodt Inc. | Adhesively connected polymeric pressure chambers and method for making the same |
| MXPA03012031A (es) * | 2001-06-21 | 2005-07-01 | Univ Yale | El monoxido de carbono mejoraresultados en transplantes de tejido y organo y suprime apoptosis. |
| US6997347B2 (en) * | 2003-07-02 | 2006-02-14 | Industrial Scientific Corporation | Apparatus and method for generating calibration gas |
| US7560076B2 (en) | 2004-08-18 | 2009-07-14 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| JP3130513U (ja) * | 2007-01-16 | 2007-03-29 | 株式会社旭製作所 | 高圧ガスカートリッジ |
| CA2681308C (en) * | 2007-03-23 | 2015-11-24 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US20110245759A1 (en) * | 2008-07-30 | 2011-10-06 | Nitric Biotherapeutics, Inc. | Methods of Treating An Infection with Nitric Oxide |
| US8607785B2 (en) * | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| JP5995724B2 (ja) * | 2009-11-20 | 2016-09-21 | ゲノ エルエルシー | 一酸化窒素送達システム |
| ES2873089T3 (es) * | 2010-02-01 | 2021-11-03 | Vero Biotech LLC | Sistema de administración de óxido nítrico |
| AU2011245476B2 (en) * | 2010-04-26 | 2016-05-12 | VERO Biotech LLC. | Delivery of ultra pure nitric oxide (NO) |
-
2012
- 2012-06-08 EP EP17202129.7A patent/EP3391891A3/en not_active Withdrawn
- 2012-06-08 CA CA2838829A patent/CA2838829A1/en not_active Abandoned
- 2012-06-08 WO PCT/US2012/041593 patent/WO2012170843A1/en not_active Ceased
- 2012-06-08 AU AU2012267620A patent/AU2012267620B2/en not_active Ceased
- 2012-06-08 JP JP2014514889A patent/JP2014520113A/ja not_active Withdrawn
- 2012-06-08 EP EP12796066.4A patent/EP2717683A4/en not_active Withdrawn
-
2016
- 2016-06-28 AU AU2016204447A patent/AU2016204447C1/en not_active Ceased
-
2017
- 2017-05-09 JP JP2017092881A patent/JP2017197541A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998003186A1 (en) * | 1996-07-18 | 1998-01-29 | Sumitomo Seika Chemicals Co., Ltd. | Mixed nitrogen monoxide gas for medical applications and process for preparing the same |
| US6109260A (en) * | 1998-02-18 | 2000-08-29 | Datex-Ohmeda, Inc. | Nitric oxide administration device with timed pulse |
| US6749834B2 (en) * | 2001-06-19 | 2004-06-15 | World Precision Instruments, Inc. | Methods and apparatus for therapeutic treatment of respiratory, cardiac and other pathologies |
| US20070104653A1 (en) * | 2004-05-11 | 2007-05-10 | Miller Christopher C | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
| US20060180147A1 (en) * | 2004-08-18 | 2006-08-17 | Cyterra Corporation | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2838829A1 (en) | 2012-12-13 |
| AU2016204447B2 (en) | 2018-01-04 |
| AU2012267620A1 (en) | 2014-01-09 |
| EP2717683A1 (en) | 2014-04-16 |
| AU2016204447A1 (en) | 2016-07-21 |
| EP3391891A2 (en) | 2018-10-24 |
| AU2016204447C1 (en) | 2018-04-05 |
| EP3391891A3 (en) | 2019-01-02 |
| JP2014520113A (ja) | 2014-08-21 |
| JP2017197541A (ja) | 2017-11-02 |
| EP2717683A4 (en) | 2015-05-06 |
| WO2012170843A1 (en) | 2012-12-13 |
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Owner name: VERO BIOTECH LLC. Free format text: FORMER NAME(S): GENO LLC |
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| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |