AU2012201983A1

AU2012201983A1 - Nucleic acid sequences encoding proteins associated with abiotic stress response and plant cells and plants with increased tolerance to environmental stress

Info

Publication number: AU2012201983A1
Application number: AU2012201983A
Authority: AU
Inventors: Agnes Chardonnens; Ruoying Chen; Bryan Mckersie; Piotr Puzio; Rodrigo Sarria-Millan; Amber Shirley; Xi-Qing Wang
Original assignee: BASF Plant Science GmbH
Current assignee: BASF Plant Science GmbH
Priority date: 2003-04-15
Filing date: 2012-04-05
Publication date: 2012-05-24

Abstract

Abstract: This invention relates generally to nucleic acid sequences encoding proteins that are associated with abiotic stress responses and abiotic stress tolerance in plants. This invention further relates to transformed plant cells with altered metabolic activity compared to a corresponding non transformed wild type plant cell, wherein the metabolic activity is altered by transformation with a Stress-Related Protein (SRP) coding nucleic acid and results in increased tolerance and/or resistance to an environmental stress as compared to a corresponding non-transformed wild type plant cell.

Description

NUCLEIC ACID SEQUENCES ENCODING PROTEINS ASSOCIATED WITH ABIOTIC STRESS RESPONSE AND PLANT CELLS AND PLANTS WITH INCREASED TOLERANCE TO ENVIRONMENTAL STRESS 5 0001.0.1 This invention relates generally to nucleic acid sequences encoding proteins that are associated with abiotic stress responses and abiotic stress tolerance in plants. 0002.0.1 This invention further relates to transformed plant cells with altered metabolic activity compared to a corresponding non transformed wild type plant cell, 10 wherein the metabolic activity is altered by transformation with a Stress-Related Protein (SRP) coding nucleic acid and results in increased tolerance and/or resistance to an environmental stress as compared to a corresponding non-transformed wild type plant cell. 0003.0.1 In particular, this invention relates to nucleic acid sequences encoding 15 proteins that confer drought, heat, cold, and/or salt tolerance and/or resistance to plants, especially by altering the metabolic activity leading to drought, heat, cold, and/or salt tolerance and/or resistance to plants. The invention also deals with methods of producing, screening for and breeding such plant cells or plants and method of detecting stress in plants cells or plants. 20 0004.0.1 Abiotic environmental stresses such as drought stress, salinity stress, heat stress and cold stress, are major limiting factors of plant growth and productivity (Boyer. 1982. Science 218, 443-448). Crop losses and crop yield losses of major crops such as rice, maize (corn) and wheat caused by these stresses represent a significant economic and political factor and contribute to food shortages in many underdeveloped 25 countries. 0005.0.1 Plants are typically exposed during their life cycle to conditions of reduced environmental water content. Most plants have evolved strategies to protect themselves against these conditions of low water or desiccation (drought). However, if the severity and duration of the drought conditions are too great, the effects on plant 30 development, growth and yield of most crop plants are profound. Continuous exposure to drought causes major alterations in the plant metabolism. These great changes in metabolism ultimately lead to cell death and consequently yield losses. 0006.0.1 Developing stress-tolerant plants is a strategy that has the potential to solve or mediate at least some of these problems (McKersie and Leshem, 1994. Stress 35 and Stress Coping in Cultivated Plants, Kluwer Academic Publishers). However, traditional plant breeding strategies to develop new lines of plants that exhibit resistance (tolerance) to these types of stresses are relatively slow and require specific resistant lines for crossing with the desired line. Limited germplasm resources for stress tolerance and incompatibility in crosses between distantly related plant species represent significant problems encountered in conventional breeding. Additionally, the cellular processes leading to drought, cold and salt tolerance are complex in nature and involve multiple mechanisms of cellular adaptation and numerous metabolic 5 pathways (McKersie and Leshem, 1994. Stress and Stress Coping in Cultivated Plants, Kluwer Academic Publishers). This multi-component nature of stress tolerance has not only made breeding for tolerance largely unsuccessful, but has also limited the ability to genetically engineer stress tolerance plants using biotechnological methods. 0007.0.1 Drought, heat, cold and salt stresses have a common theme important 10 for plant growth and that is water availability. Plants are exposed during their entire life cycle to conditions of reduced environmental water content. Most plants have evolved strategies to protect themselves against these conditions. However, if the severity and duration of the drought conditions are too great, the effects on plant development, growth and yield of most crop plants are profound. Since high salt content in some soils 15 result in less available water for cell intake, its effect is similar to those observed under drought conditions. Additionally, under freezing temperatures, plant cells loose water as a result of ice formation that starts in the apoplast and withdraws water from the symplast (McKersie and Leshem, 1994. Stress and Stress Coping in Cultivated Plants, Kluwer Academic Publishers). Commonly, a plant's molecular response mechanisms to 20 each of these stress conditions are similar. 0008.0.1 The results of current research indicate that drought tolerance is a complex quantitative trait and that no real diagnostic marker is available yet. High salt concentrations or dehydration may cause damage at the cellular level during drought stress but the precise injury is not entirely clear (Bray, 1997. Trends Plant Sci. 2, 48 25 54). This lack of a mechanistic understanding makes it difficult to design a transgenic approach to improve drought tolerance. However, an important consequence of damage may be the production of reactive oxygen radicals that cause cellular injury, such as lipid peroxidation or protein and nucleic acid modification. Details of oxygen free radical chemistry and their reaction with cellular components such as cell 30 membranes have been described (McKersie and Leshem, 1994. Stress and Stress Coping in Cultivated Plants, Kluwer Academic Publishers). 0009.0.1 It is the object of this invention to identify new, unique genes capable of conferring stress tolerance to plants upon expression or over-expression. 0010.0.1 It is further object of this invention to identify, produce and breed new, 35 unique stress tolerant and/or resistant plant cells or plants and methods of inducing and detecting stress tolerance and/or resistance in plants or plant cells. It is a further object to identify new methods to detect stress tolerance and/or resistance in plants or plant cells. It is also the object of this invention to identify new, unique genes capable of conferring stress tolerance to plants upon expression or over expression. 0011.0.1 The present invention provides a transformed plant cell with altered 5 metabolic activity compared to a corresponding non transformed wild type plant cell, wherein the metabolic activity is altered by transformation with a Stress-Related Protein (SRP) coding nucleic acid and results in increased tolerance and/or resistance to an environmental stress as compared to a corresponding non-transformed wild type plant cell. 10 0012.0.2 The present invention provides a transgenic plant cell transformed by Stress-Related Protein (SRP) coding nucleic acid. selected from the group consisting of: a) nucleic acid molecule encoding one of the polypeptides shown in Fig. la, lb or 1c or a fragment thereof, which confers an altered metabolic activity 15 in an organism or a part thereof; b) nucleic acid molecule comprising one of the nucleic acid molecule shown in Fig. la, 1bor 1c; c) nucleic acid molecule whose sequence can be deduced from a polypeptide sequence encoded by a nucleic acid molecule of (a) or (b) as a result of the 20 degeneracy of the genetic code and conferring an altered metabolic activity in an organism or a part thereof; d) nucleic acid molecule which encodes a polypeptide which has at least 50% identity with the amino acid sequence of the polypeptide encoded by the nucleic acid molecule of (a) to (c) and conferring an altered metabolic 25 activity in an organism or a part thereof; e) nucleic acid molecule which hybridizes with a nucleic acid molecule of (a) to (c) under stringent hybridisation conditions and conferring an altered metabolic activity in an organism or a part thereof; f) nucleic acid molecule which encompasses a nucleic acid molecule which is 30 obtained by amplifying nucleic acid molecules from a cDNA library or a genomic library using the primers as shown in table 2 and conferring an altered metabolic activity in an organism or a part thereof; g) nucleic acid molecule encoding a polypeptide which is isolated with the aid of monoclonal antibodies against a polypeptide encoded by one of the 35 nucleic acid molecules of (a) to (f) and conferring an altered metabolic activity in an organism or a part thereof; h) nucleic acid molecule encoding a polypeptide comprising the consensus sequence shown in Fig. 2 and conferring an altered metabolic activity in an organism or a part thereof; and i) nucleic acid molecule which is obtainable by screening a suitable nucleic 5 acid library under stringent hybridization conditions with a probe comprising one of the sequences of the nucleic acid molecule of (a) to (h) or with a fragment thereof having at least 15 nt, preferably 20 nt, 30 nt, 50 nt, 100 nt, 200 nt or 500 nt of the nucleic acid molecule characterized in (a) to (h) and conferring an altered metabolic activity in an organism or a part thereof. 10 or comprising a sequence which is complementary thereto. 0012.1.0 For the purpose of the present invention the term Fig. 1a, 1b or 1c involves and means the SEQ ID NO: 1 to 556 and the term consensus sequence 15 shown in Fig. 2 means SEQ ID NO: 557 to 560. Particularly, the term Fig. 1a means SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35, 36, 37,38, 39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59, 60,61, 62,63,64, 65,66, 67,68, 69,70,71,72,73,74,75,76,77,78,79,80,81,82, 20 83,84,85,86,87,88,89, 90, 91,92, 93,94, 95,96,97, 98,99,100,101,102,103, 104, 105, 106,107,108,109,110, 111, 112,113,114,115,116,117,118,119,120, 121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136, 137, 138, 139, 140,141,142,143,144,145,146,147,148,149,150,151,152,153,154, 155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170, 171, 25 172, 173, 174,175,176,177,178, 179, 180, 181,182,183,184,185,186,187, 188, 189, 190, 191,192,193,194,195, 196, 197, 198,199,200,201,202,203,204,205, 206,207,208,209,210,211,212,213,214,215,216,217,218,219,220,221,222, 223,224,225,226,227,228,229,230,231,232,233,234,235,236,237,238,239, 240,241,242,243,244,245,246,247,248,249,250,251,252,253,254,255,256, 30 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269 and/or 270, the term Fig. lb means SEQ ID NO: 271, 272, 273, 274, 275, 276, 277, 278, 279, 280, 281, 282, 283, 284, 285, 286, 287, 288, 289 and/or 290, the term Fig. 1c means SEQ ID NO: 291, 292, 293, 294, 295, 296, 297, 298, 299, 300, 301, 302, 303,304,305,306,307, 308, 309, 310,311,312,313,314,315,316, 317, 35 318, 319, 320,321,322,323,324, 325, 326, 327,328,329,330,331,332,333, 334, 335, 336, 337,338,339,340,341, 342, 343, 344,345,346,347,348,349,350, 351, 352, 353, 354,355,356,357,358, 359, 360, 361,362,363,364,365,366,367, 368, 369, 370, 371,372,373,374,375, 376, 377, 378,379,380,381,382,383,384, 385, 386, 387, 388,389,390,391,392, 393, 394, 395,396,397,398,399,400,401,402, 403,404,405,406,407,408,409,410,411,412,413,414,415,416,417,418,419, 420,421,422,423,424,425,426,427,428,429,430,431,432,433,434,435,436, 5 437,438,439,440,441,442,443,444,445,446,447,448,449,450,451,452,453, 454,455,456,457,458,459,460,461,462,463,464,465,466,467,468,469,470, 471,472,473,474,475,476,477,478,479,480,481,482,483,484,485,486,487, 488,489,490,491,492,493,494,495,496,497,498,499,500,501,502,503,504, 505,506,507,508,509,510,511,512,513,514,515,516,517,518,519,520,521, 10 522,523,524,525,526,527,528,529,530,531,532,533,534,535,536,537,538, 539,540,541,542,543,544,545,546,547,548,549,550,551,552,553,554,555 and/or 556, and the term consensus sequence shown in Fig. 2 means SEQ ID NO: 557, 558, 559 and/or 560. 15 0012.2.0 More precisely, when polypeptides or proteins according to Fig. 1a are mentioned, then the SEQ ID NO 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32,34, 36,38,40,42,44,46,48,50,52,54,56,58,60, 62,64, 66,68,70,72,74,76, 78,80,82,84,86,88,90, 92, 94,96, 98,100,102, 104, 106, 108,110,112,114,116, 20 118,120,122,124,126,128,130,132,134,136,138,140,142,144,146,148,150, 152,154,156,158,160,162,164,166,168,170,172,174,176,178,180,182, 184, 186, 188, 190,192,194,196,198,200,202,204,206,208,210,212,214,216,218, 220,222,224,226,228,230,232,234,236,238,240,242,244,246,248,250,252, 254, 256, 258, 260, 262, 264, 266, 268 and/or 270 are meant; 25 when polypeptides or proteins according to Fig. 1b are mentioned, then the SEQ ID NO 272, 274, 276, 278, 280, 282, 284, 286, 288 and/or 290 are meant; when polypeptides or proteins according to Fig. 1c are mentioned, then the SEQ ID NO 292,294,296,298,300,302,304, 306, 308, 310,313,315,317,319,321,323, 325, 327, 329, 331,333,335,337,339, 341, 343, 345,347,349,351,353,355,357, 359, 30 361, 363, 365,367,369,371,373, 375, 377, 379,381,383,385,387,389,391, 393, 395, 397, 399,401,403,405,407,409,411,413,415,417,419,421,423,425,427, 429,431,433,435,437,439,441,443,445,447,449,451,453,455,457,459,461, 463,465,467,469,471,473,475,477,479,481,483,485,487,489,491,493,495, 497,499,501,503,505,507,509,511,513,515,517,519,521,523,526,528,530, 35 532, 534, 536, 538, 540, 542, 544, 546, 548, 550, 552, 554 and/or 556 are meant. More precisely, when polynucleotides or nucleic acid molecules according to Fig. 1a are mentioned, then the SEQ ID NO 1,3,5,7,9, 11, 13, 15, 17, 19,21,23,25,27,29, 31,33, 35,37,39,41,43,45,47,49,51,53,55,57,59, 61,63, 65,67, 69,71,73,75, 77,79,81,83,85,87,89,91,93,95,97,99,101,103,105,107,109,111,113,115, 117, 119, 121,123,125,127,129,131,133,135,137,139,141,143,145,147,149, 151,153,155,157,159,161,163,165,167,169,171,173,175,177,179,181,183, 5 185,187,189,191,193,195,197,199,201,203,205,207,209,211,213,215,217, 219,221,223,225,227,229,231,233,235,237,239,241,243,245,247,249,251, 253, 255, 257, 259, 261, 263, 265, 267 and/or 269 are meant; when polynucleotides or nucleic acid molecules according to Fig. lb are mentioned, then the SEQ ID NO 271, 273, 275, 277, 279, 281, 283, 285, 287 and/or 289 are 10 meant; when polynucleotides or nucleic acid molecules according to Fig. 1c are mentioned, then the SEQ ID NO 291, 293, 295, 297, 299, 301, 303, 305, 307, 309, 311, 312, 314, 316, 318, 320, 322, 324, 326, 328, 330, 332, 334, 336, 338, 340, 342, 344, 346, 348, 350, 352, 354, 356, 358, 360, 362, 364, 366, 368, 370, 372, 374, 376, 378, 380, 382, 15 384, 386, 388, 390, 392, 394, 396, 398, 400, 402, 404, 406, 408, 410, 412, 414, 416, 418, 420, 422, 424, 426, 428, 430, 432, 434, 436, 438, 440, 442, 444, 446, 448, 450, 452, 454, 456, 458, 460, 462, 464, 466, 468, 470, 472, 474, 476, 478, 480, 482, 484, 486, 488, 490, 492, 494, 496, 498, 500, 502, 504, 506, 508, 510, 512, 514, 516, 518, 520, 522, 524, 525, 527, 529, 531, 533, 535, 537, 539, 541, 543, 545, 547, 549, 551, 20 553 and/or 555 are meant. 0013.0.1 As used herein, the term "metabolite" refers to intermediate substances, preferably such of low molecular weight, which occur during anabolism and catabolism in a cell or plant, in other words a substance produced or consumed by metabolism. 25 0014.0.1 The term "altered metabolic activity" refers to the change (increase or decrease) of the amount, concentration or activity (meaning here the effective concentration for the purposes of chemical reactions and other mass action) of a metabolite in a specific volume relative to a corresponding volume (e.g. in an organism, a tissue, a cell or a cell compartment) of a control, reference or wild type, including the 30 de novo creation of the activity or expression, measured for example by one of the methods described herein below, which is changed (increased or decreased) as compared to a corresponding non transformed wild type plant cell. 0015.0.2 The terms "increased", "rised", "extended", "enhanced", "improved" or "amplified" relate to a corresponding change of a property in an organism, a part of an 35 organism such as a tissue, seed, root, leave, flower etc. or in a cell and are interchangeable. Preferably, the overall activity in the volume is increased or enhanced in cases if the increase or enhancement is related to the increase or enhancement of an activity of a gene product, independent whether the amount of gene product or the specific activity of the gene product or both is increased or enhanced or whether the amount, stability or translation efficacy of the nucleic acid sequence or gene encoding for the gene product is increased or enhanced. The terms "reduction", "decrease" or 5 "deletion" relate to a corresponding change of a property in an organism, a part of an organism such as a tissue, seed, root, leave, flower etc. or in a cell. Preferably, the overall activity in the volume is reduced, decreased or deleted in cases if the reduction, decrease or deletion is related to the reduction, decrease or deletion of an activity of a gene product, independent whether the amount of gene product or the specific activity 10 of the gene product or both is reduced, decreased or deleted or whether the amount, stability or translation efficacy of the nucleic acid sequence or gene encoding for the gene product is reduced, decreased or deleted. 0016.0.2 The terms "increase" or "decrease" relate to a corresponding change of a property in an organism or in a part of an organism, such as a tissue, seed, root, 15 leave, flower etc. or in a cell. Preferably, the overall activity in the volume is increased in cases the increase relates to the increase of an activity of a gene product, independent whether the amount of gene product or the specific activity of the gene product or both is increased or generated or whether the amount, stability or translation efficacy of the nucleic acid sequence or gene encoding for the gene product is 20 increased. 0017.0.2 Under "change of a property" it is understood that the activity, expression level or amount of a gene product or the metabolite content is changed in a specific volume relative to a corresponding volume of a control, reference or wild type, including the de novo creation of the activity or expression. 25 0018.0.2 The terms "increase" or "decrease" include the change of said property in only parts of the subject of the present invention, for example, the modification can be found in compartment of a cell, like a organelle, or in a part of a plant, like tissue, seed, root, leave, flower etc. but is not detectable if the overall subject, i.e. complete cell or plant, is tested. Preferably, the increase or decrease is found cellular, thus the 30 term "increase of an activity" or "increase of a metabolite content" relates to the cellular increase compared to the wild type cell. 0019.0.2 Accordingly, the term "increase" or "decrease" means that the specific activity of an enzyme as well as the amount of a compound or metabolite, e.g. of a polypeptide, a nucleic acid molecule or of the fine chemical of the invention or an 35 encoding mRNA or DNA, can be increased or decreased in a volume. 0020.0.2 The terms "wild type", "control" or "reference" are exchangeable and can be a cell or a part of organisms such as an organelle or a tissue, or an organism, in particular a microorganism or a plant, which was not modified or treated according to the herein described process according to the invention. Accordingly, the cell or a part of organisms such as an organelle or a tissue, or an organism, in particular a microorganism or a plant used as wild type, control or reference corresponds to the 5 cell, organism or part thereof as much as possible and is in any other property but in the result of the process of the invention as identical to the subject matter of the invention as possible. Thus, the wild type, control or reference is treated identically or as identical as possible, saying that only conditions or properties might be different which do not influence the quality of the tested property. 10 0021.0.2 Preferably, any comparison is carried out under analogous conditions. The term "analogous conditions" means that all conditions such as, for example, culture or growing conditions, assay conditions (such as buffer composition, temperature, substrates, pathogen strain, concentrations and the like) are kept identical between the experiments to be compared. 15 0022.0.2 The "reference", "control", or "wild type" is preferably a subject, e.g. an organelle, a cell, a tissue, an organism, in particular a plant or a microorganism, which was not modified or treated according to the herein described process of the invention and is in any other property as similar to the subject matter of the invention as possible. The reference, control or wild type is in its genome, transcriptome, proteome or 20 metabolome as similar as possible to the subject of the present invention. Preferably, the term "reference-" "control-" or "wild type-"-organelle, -cell, -tissue or -organism, in particular plant or microorganism, relates to an organelle, cell, tissue or organism, in particular plant or microorganism, which is nearly genetically identical to the organelle, cell, tissue or organism, in particular microorganism or plant, of the present invention or 25 a part thereof preferably 95%, more preferred are 98%, even more preferred are 99,00%, in particular 99,10%, 99,30%, 99,50%, 99,70%, 99,90%, 99,99%, 99, 999% or more. Most preferable the "reference", "control", or "wild type" is a subject, e.g. an organelle, a cell, a tissue, an organism, which is genetically identical to the organism, cell or organelle used according to the process of the invention except that the 30 responsible or activity conferring nucleic acid molecules or the gene product encoded by them are amended, manipulated, exchanged or introduced according to the inventive process. 0023.0.2 Preferably, the reference, control or wild type differs form the subject of the present invention only in the cellular activity of the polypeptide of the invention, e.g. 35 as result of an increase in the level of the nucleic acid molecule of the present invention or an increase of the specific activity of the polypeptide of the invention, e.g. by or in the expression level or activity of an protein having the activity of an Stress-Related Protein (SRP) or its homologs, its biochemical or genetical causes and the altered metabolic activity. 0024.0.2 In case, a control, reference or wild type differing from the subject of the present invention only by not being subject of the process of the invention can not be 5 provided, a control, reference or wild type can be an organism in which the cause for the modulation of an activity conferring the altered metabolic activity or expression of the nucleic acid molecule of the invention as described herein has been switched back or off, e.g. by knocking out the expression of responsible gene product, e.g. by antisense inhibition, by inactivation of an activator or agonist, by activation of an 10 inhibitor or antagonist, by inhibition through adding inhibitory antibodies, by adding active compounds as e.g. hormones, by introducing negative dominant mutants, etc. A gene production can for example be knocked out by introducing inactivating point mutations, which lead to an enzymatic activity inhibition or a destabilization or an inhibition of the ability to bind to cofactors etc. 15 0025.0.2 Accordingly, preferred reference subject is the starting subject of the present process of the invention. Preferably, the reference and the subject matter of the invention are compared after standardization and normalization, e.g. to the amount of total RNA, DNA, or protein or activity or expression of reference genes, like housekeeping genes, such as ubiquitin, actin or ribosomal proteins. 20 0026.0.2 A series of mechanisms exists via which a modification of the a protein, e.g. the polypeptide of the invention can directly or indirectly affect the yield, production and/or production efficiency of the amino acid. 0027.0.2 For example, the molecule number or the specific activity of the polypeptide or the nucleic acid molecule may be increased. Larger amounts of the fine 25 chemical can be produced if the polypeptide or the nucleic acid of the invention is expressed de novo in an organism lacking the activity of said protein. However, it is also possible to increase the expression of the gene which is naturally present in the organisms, for example by modifying the regulation of the gene, or by increasing the stability of the corresponding mRNA or of the corresponding gene product encoded by 30 the nucleic acid molecule of the invention, or by introducing homologous genes from other organisms which are differently regulated, eg. not feedback sensitive. 0028.0.2 This also applies analogously to the combined increased expression of the nucleic acid molecule of the present invention or its gene product with that of further enzymes of the amino acid biosynthesis pathways, e.g. which are useful for the 35 synthesis of the fine chemicals. 0029.0.2 The increase, decrease or modulation according to this invention can be constitutive, e.g. due to a stable permanent transgenic expression or to a stable mutation in the corresponding endogenous gene encoding the nucleic acid molecule of the invention or to a modulation of the expression or of the behaviour of a gene conferring the expression of the polypeptide of the invention, or transient, e.g. due to an transient transformation or temporary addition of a modulator such as a agonist or 5 antagonist or inducible, e.g. after transformation with a inducible construct carrying the nucleic acid molecule of the invention under control of a inducible promoter and adding the inducer, e.g. tetracycline or as described herein below. 0030.0.2 The increase in activity of the polypeptide amounts in a cell, a tissue, a organelle, an organ or an organism or a part thereof preferably to at least 5%, 10 preferably to at least 20% or at to least 50%, especially preferably to at least 70%, 80%, 90% or more, very especially preferably are to at least 200%, most preferably are to at least 500% or more in comparison to the control, reference or wild type. 0031.0.2 The specific activity of a polypeptide encoded by a nucleic acid molecule of the present invention or of the polypeptide of the present invention can be tested as 15 described in the examples. In particular, the expression of a protein in question in a cell, e.g. a plant cell or a microorganism and the detection of an increase the fine chemical level in comparison to a control is an easy test and can be performed as described in the state of the art. 0032.0.2 The term "increase" includes, that a compound or an activity is 20 introduced into a cell de novo or that the compound or the activity has not been detectable before, in other words it is "generated". 0033.0.2 Accordingly, in the following, the term "increasing" also comprises the term "generating" or "stimulating". The increased activity manifests itself in an increase of the fine chemical. 25 0034.0.1 The transformed plant cells are compared to the corresponding non transformed wild type of the same genus and species under otherwise identical conditions (such as, for example, culture conditions, age of the plants and the like). In this context, a change in metabolic activity of at least 10%, advantageously of at least 20%, preferably at least 30%, especially preferably of at least 40%, 50% or 60%, very 30 especially preferably of at least 70%, 80%, 90%, 95% or even 100% or more, in comparison with the non-transformed organism is advantageous. 0035.0.1 Preferably the change in metabolite concentration of the transformed plant cells is the changed compared to the corresponding non-transformed wild type. Preferably the change in metabolite concentration is measured by HPLC and 35 calculated by dividing the peak height or peak area of each analyte (metabolite) through the peak area of the respective internal standards. Data is normalised using the individual sample fresh weight. The resulting values are divided by the mean values found for wild type plants grown under control conditions and analysed in the same sequence, resulting in the so-called ratios, which represent values independent of the analytical sequence. These ratios indicate the behavior of the metabolite concentration of the transformed plants in comparison to the concentration in the wild type control 5 plants. 0036.0.1 According to this method, the change in at least one metabolite concentration of the transformed plant cells compared to the corresponding non transformed wild type is at least 10%, advantageously of at least 20%, preferably at least 40%, 60% or 80%, especially preferably of at least 90%, 100% or 200%, very 10 especially preferably of at least 700%, 800%, 900% 1000% or more. 0037.0.1 Data significance can be determinated by all statistical methods known by a person skilled in the art, preferably by a t-test, more preferably by the student t test. 0038.0.1 Altered metabolic activity also refers to metabolites that, compared to a 15 corresponding non transformed wild type plant cell, are not produced after transformation or are only produced after transformation. 0039.0.1 Preferred metabolites of the invention are 2,3-dimethyl-5-phytylquinol or 2-hydroxy-palmitic acid or 3,4-dihydroxyphenylalanine (= dopa) or 3-hydroxy-palmitic acid or 5-oxoproline or alanine or alpha linolenic acid (c18:3 (c9, c12, c15)) or alpha 20 tocopherol or aminoadipic acid or anhydroglucose or arginine or aspartic acid or beta apo-8' carotenal or beta-carotene or beta-sitosterol or beta-tocopherol or (delta-7 cis,10-cis)-hexadecadienic acid or hexadecatrienic acid or margaric acid or delta-15 cis-tetracosenic acid or ferulic acid or campesterol or cerotic acid (c26:0) or citrulline or cryptoxanthine or eicosenoic acid (20:1) or fructose or fumarate or galactose or 25 gamma-aminobutyric acid or gamma-tocopherol or gluconic acid or glucose or glutamic acid or glutamine or glycerate or glycerinaldehyd or glycerol or glycerol-3-phosphate or glycine or homoserine or inositol or isoleucine or iso-maltose or isopentenyl pyrophosphate or leucine or lignoceric acid (c24:0) or linoleic acid (c18:2 (c9, c12)) or luteine or lycopene or malate or mannose or methionine or methylgalactofuranoside or 30 methylgalactopyranoside or methylgalactopyranoside or palmitic acid (c16:0) or phenylalanine or phosphate or proline or putrescine or pyruvat or raffinose or ribonic acid or serine or shikimate or sinapine acid or stearic acid (c18:0) or succinate or sucrose or threonine or triacontanoic acid or tryptophane or tyrosine or ubichinone or udp-glucose or valine or zeaxanthine. 35 0040.0.1 Metabolic activity may also be altered concerning one or more derivates of one or more of the above metabolites.

0041.0.1 Preferably metabolic activity is altered concerning one or more metabolites selected from the group consisting of all of the above metabolites. 0042.0.1 Alternatively metabolic activity may be altered concerning one or more metabolites selected from the group consisting of mannose, inositol, phosphate, 5 aspartic acid, isoleucine, leucine, gamma-aminobutyric acid, glycerinaldehyd, sucrose, campesterol, valine, beta-tocopherol,. ubichinone, palmitic acid (c16:0), 2-hydroxy palmitic acid, 2,3-dimethyl-5-phytylquinol, beta-carotene, alpha-linolenic acid (c18:3 (c9, c12, c15)), lycopene. 0043.0.1 Alternatively metabolic activity may be altered concerning one or more 10 metabolites selected from the group consisting of methylgalactofuranoside, beta sitosterol, delta-15-cis-tetracosenic acid (c24:1 me), margaric acid (c17:0 me), stearic acid (c18:0), methylgalactopyranoside, gamma-tocopherol, linoleic acid (c18:2 (c9, c12)), hexadecatrienic acid (c16:3 me), shikimate, raffinose, glutamic acid, glutamine, udp-glucose, proline, threonine, isopentenyl pyrophosphate, 5-oxoproline, ferulic acid, 15 sinapine acid. 0044.0.1 Alternatively metabolic activity may be altered concerning one or more metabolites selected from the group consisting of tryptophane, citrulline, serine, alanine, glycerate, arginine, 3-hydroxy-palmitic acid, putrescine, 3,4 dihydroxyphenylalanine (=dopa), alpha-tocopherol, aminoadipic acid, anhydroglucose, 20 beta-apo-8' carotenal, delta-7-cis,10-cis-hexadecadienic acid (c16:2 me), cerotic acid (c26:0), cryptoxanthine, eicosenoic acid (20:1), fructose, fumarate. 0045.0.1 Alternatively metabolic activity may be altered concerning one or more metabolites selected from the group consisting of galactose, gluconic acid, glucose, glycerol, glycerol-3-phosphate, glycine, homoserine, iso-maltose, lignoceric acid 25 (c24:0), luteine, malate, triacontanoic acid, methionine, phenylalanine, pyruvate, ribonic acid, succinate, tyrosine, zeaxanthine. 0046.0.1 The present invention provides a transgenic plant cell, wherein expression of said nucleic acid sequence in the plant cell results altered metabolic activity leading to increased tolerance and/or resistance to environmental stress as 30 compared to a corresponding non-transformed wild type plant cell. One preferred wild type plant cell is a non-transformed Arabidopsis plant cell. An example here is the Arabidopsis wild type C24 (Nottingham Arabidopsis Stock Centre, UK; NASC Stock N906). 0047.0.1 Other preferred wild type plant cells are a non-transformed from plants 35 selected from the group consisting of maize, wheat, rye, oat, triticale, rice, barley, soybean, peanut, cotton, rapeseed, canola, manihot, pepper, sunflower, flax, borage, safflower, linseed, primrose, rapeseed, turnip rape, tagetes, solanaceous plants, potato, tobacco, eggplant, tomato, Vicia species, pea, alfalfa, coffee, cacao, tea, Salix species, oil palm, coconut, perennial grass and forage crops. 0048.0.1 More preferred wild type plant cells are a non-transformed Linum plant cell, preferably Linum usitatissimum, more preferably the variety Brigitta, Golda, Gold 5 Merchant, Helle, Juliel, Olpina, Livia, Marlin, Maedgold, Sporpion, Serenade, Linus, Taunus, Lifax or Liviola, a non-transformed Heliantus plant cell, preferably Heliantus annuus, more preferably the variety Aurasol, Capella, Flavia, Flores, Jazzy, Palulo, Pegasol, PIR64A54, Rigasol, Sariuca, Sideral, Sunny, Alenka, Candisol or Floyd, or a non-transformed Brassica plant cell, preferably Brassica napus, more preferably the 10 variety Dorothy, Evita, Heros, Hyola, Kimbar, Lambada, Licolly, Liconira, Licosmos, Lisonne, Mistral, Passat, Serator, Siapula, Sponsor, Star, Caviar, Hybridol, Baical, Olga, Lara, Doublol, Karola, Falcon, Spirit, Olymp, Zeus, Libero, Kyola, Licord, Lion, Lirajet, Lisbeth, Magnum, Maja, Mendel, Mica, Mohican, Olpop, Ontarion, Panthar, Prinoe, Pronio, Susanna, Talani, Titan, Transfer, Wiking, Woltan, Zeniah, Artus, 15 Contact or Smart. 0049.0.1 The expression of said nucleic acid sequence in the plant cell may directly or indirectly influence the metabolic activity of the transformed plant cells. Preferably they influence the activity of the above metabolites. 0050.0.1 Preferably metabolic activity may be altered by transformation with one 20 or more Stress-Related Protein (SRP) coding nucleic acid selected from the group comprising the nucleic acid of Fig. la, lb or 1c homologs of the afore mentioned sequences. 0051.0.1 It is within the scope of the invention to identify the genes encoded by a nucleic acid sequence selected from the group consisting of the nucleic acid of Fig. 1 a, 25 lb or 1c and/or homologs thereof in target plants, especially crop plants, and then express the corresponding gene to achieve the altered metabolic activity resulting in increased tolerance and/or resistance to environmental stress. Consequently the invention is not limited to a specific plant. 0052.0.2 A protein having an activity conferring an altered metabolic activity 30 preferably has the structure of the polypeptide described herein, in particular of the polypeptides comprising the consensus sequence shown in Fig. 2 or of the polypeptide as shown in Fig. 1a, 1b or 1c or the functional homologues thereof as described herein, or is encoded by the nucleic acid molecule characterized herein or the nucleic acid molecule according to the invention, for example by the nucleic acid molecule as 35 shown in Fig. 1a, lb or 1c or its herein described functional homologues and has the herein mentioned activity.

0053.0.1 It is further possible to detect environmental stress in plant cells or plants by screening the plant cells for altered metabolic activity as compared to non-stress conditions. This allows for monitoring of stress levels in plants, even when no symptoms are visible. Therefore counter action can be taken earlier and e.g. crop 5 losses minimized by timely watering. 0054.0.1 It is also within the scope of the invention to screen plant cells or plants for increased tolerance and/or resistance to environmental stress by screening the plant cells under stress conditions for altered metabolic activity as compared to non stress conditions. This allows selection of plants with increased tolerance and/or 10 resistance to environmental stress without the identification of genes or visual symptoms. 0055.0.1 With the invention it is further possible to breed plant cells or plants towards increased tolerance and/or resistance to environmental stress by screening the plant cells under stress conditions for altered metabolic activity as compared to 15 non-stress conditions and selecting those with increased tolerance and/or resistance to environmental stress. The screening for metabolite activity is faster and easier than e.g. screening for genes. 0056.0.1 Screening is well known to those skilled in the art and generally refers to the search for a particular attribute or trait. In the invention this trait in a plant or plant 20 cell is preferably the concentration of a metabolite, especially preferred the concentration of the above metabolites. The methods and devices for screening are familiar to those skilled in the art and include GC (gas chromatography), LC (liquid chromatography), HPLC (high performance (pressure) liquid chromatography), MS (mass spectrometry), NMR (nuclear magnetic resonance) spectroscopy, IR (infra red) 25 spectroscopy, photometric methods etc and combinations of these methods. 0057.0.1 Breeding is also customary knowledge for those skilled in the art. It is understood as the directed and stable incorporation of a particular attribute or trait into a plant or plant cell. 0058.0.1 The various breeding steps are characterized by well-defined human 30 intervention such as selecting the lines to be crossed, directing pollination of the parental lines, or selecting appropriate progeny plants. Different breeding measures can be taken, depending on the desired properties. All the techniques are well known by a person skilled in the art and include for example, but are not limited to hybridization, inbreeding, backcross breeding, multiline breeding, variety blend, 35 interspecific hybridization, aneuploid techniques, etc. Hybridization techniques also can include the sterilization of plants to yield male or female sterile plants by mechanical, chemical, or biochemical means. Cross pollination of a male sterile plant with pollen of a different line assures that the genome of the male sterile but female fertile plant will uniformly obtain properties of both of the parental lines. The transgenic seeds and plants according to the invention can therefor be used for the breeding of improved plant lines, which can increase the effectiveness of conventional methods such as 5 herbicide or pesticide treatment or which allow one to dispense with said methods due to their modified genetic properties. Alternatively new crops with improved stress tolerance, preferably drought and temperature, can be obtained, which, due to their optimized genetic "equipment", yield harvested product of better quality than products that were not able to tolerate comparable adverse developmental conditions. 10 0059.0.1 The invention provides that the environmental stress can be salinity, drought, temperature, metal, chemical, pathogenic and oxidative stresses, or combinations thereof, preferably drought and/or temperature. 0060.0.1 The object of the invention is a transgenic plant cell, wherein the SRP (=stress related protein) is selected preferably from yeast, preferably Saccharomyces 15 cerevisiae, or E. coli or a plant, preferably Brassica napus, Glycine max, or Oryza sativa. 0061.0.1 Object of the invention is also a transgenic plant cell, wherein the SRP coding nucleic acid is at least about 50 % homologous to one of the nucleic acid of Fig. la, 1b or 1c. 20 0062.0.1 In the transgenic plant cell of the invention, the expression of said nucleic acid results in increased tolerance to an environmental stress, which is preferably achieved by altering metabolic activity, as compared to a corresponding non-transformed wild type plant cell. Herein, the environmental stress is selected from the group consisting of salinity, drought, temperature, metal, chemical, pathogenic and 25 oxidative stresses, or combinations thereof, preferably drought and/or temperature. 0063.0.2 The term "expression" refers to the transcription and/or translation of a codogenic gene segment or gene. As a rule, the resulting product is an mRNA or a protein. However, expression products can also include functional RNAs such as, for example, antisense, nucleic acids, tRNAs, snRNAs, rRNAs, RNAi, siRNA, ribozymes 30 etc. Expression may be systemic, local or temporal, for example limited to certain cell types, tissue, organs or time periods. 0064.0.2 Unless otherwise specified, the terms "polynucleotides", "nucleic acid" and "nucleic acid molecule" are interchangeably in the present context. Unless otherwise specified, the terms "peptide", "polypeptide" and "protein" are 35 interchangeably in the present context. The term "sequence" may relate to polynucleotides, nucleic acids, nucleic acid molecules, peptides, polypeptides and proteins, depending on the context in which the term "sequence" is used. The terms "gene(s)", "polynucleotide", "nucleic acid sequence", "nucleotide sequence", or "nucleic acid molecule(s)" as used herein refers to a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides. The terms refer only to the primary structure of the molecule. 5 0065.0.2 Thus, the terms "gene(s)", "polynucleotide", "nucleic acid sequence", "nucleotide sequence", or "nucleic acid molecule(s)" as used herein include double and single-stranded DNA and RNA. They also include known types of modifications, for example, methylation, "caps", substitutions of one or more of the naturally occurring nucleotides with an analog. Preferably, the DNA or RNA sequence of the invention 10 comprises a coding sequence encoding the herein defined polypeptide. 0066.0.2 A "coding sequence" is a nucleotide sequence, which is transcribed into mRNA and/or translated into a polypeptide when placed under the control of appropriate regulatory sequences. The boundaries of the coding sequence are determined by a translation start codon at the 5'-terminus and a translation stop codon 15 at the 3'-terminus. A coding sequence can include, but is not limited to mRNA, cDNA, recombinant nucleotide sequences or genomic DNA, while introns may be present as well under certain circumstances. 0067.0.2 For the purposes of the invention, as a rule the plural is intended to encompass the singular and vice versa. 20 0068.0.1 Further, the transgenic plant cell is derived from a monocotyledonous plant. Alternativ, the transgenic plant cell is derived from a dicotyledonous plant. Preferably, the transgenic plant cell is selected from the group consisting of maize, wheat, rye, oat, triticale, rice, barley, soybean, peanut, cotton, rapeseed, canola, manihot, pepper, sunflower, flax, borage, sufflower, linseed, primrose, rapeseed, turnip 25 rape, tagetes, solanaceous plants, potato, tabacco, eggplant, tomato, Vicia species, pea, alfalfa, coffee, cacao, tea, Salix species, oil palm, coconut, perennial grass, forage crops and Arabidopsis thaliana. Moreover, the transgenic plant cell of the present invention can be derived from a gymnosperm plant. Preferably, the plant is selected from the group of spruce, pine and fir. 30 0069.0.1 The invention further provides a seed produced by a transgenic plant transformed by a SRP coding nucleic acid, wherein the plant is true breeding for increased tolerance to environmental stress, which is preferably achieved by altering metabolic activity, as compared to a wild type plant cell. The transgenic plant might be a monocot, a dicot or a gymnosperm plant. The invention further provides a seed 35 produced by a transgenic plant expressing an SRP wherein the plant is true breeding for increased tolerance to environmental stress, which is preferably achieved by altering metabolic activity, as compared to a wild type plant cell. The invention pertains to a seed produced by a transgenic plant, wherein the seed is genetically homozygous for a transgene conferring an increased tolerance to environmental stress, which is preferably achieved by altering metabolic activity, as compared to a wild type plant. 0070.0.1 The invention further provides an agricultural product produced by any of 5 the below-described transgenic plants, plant parts such as leafs, petal, anther, roots, tubers, stems, buds, flowers or seeds. The invention further provides a isolated recombinant expression vector comprising a SRP encoding nucleic acid. 0071.0.1 The invention further provides a method of producing a transgenic plant with a SRP coding nucleic acid, wherein expression of the nucleic acid in the plant 10 results in increased tolerance and/or resistance to an environmental stress, which is preferably achieved by altering metabolic activity, as compared to a corresponding non-transformed wild type plant cell, comprising a) transforming a plant cell with an expression vector including a SRP encoding nucleic acid selected from the group comprising the nucleic 15 acid of Fig. 1 a, 1b or 1 c and/or homologs or parts thereof and b) generating from the plant cell a transgenic plant with an increased tolerance to environmental stress as compared to a corresponding non transformed wild type plant. 0072.0.1 With regard to invention described here, "transformed or transgene" 20 means all those plants or parts thereof which have been brought about by genetic manipulation methods and in which either c) one or more genes, preferably encoded by one or more nucleic acid sequences as depicted in Fig. 1a, lb or 1c and/or a homolog thereof, or 25 d) a genetic regulatory element, for example a promoter, which is functionally linked e.g. to the nucleic acid sequence as depicted in Fig. 1 a, 1b or 1 c and/or a homolog thereof, or e) (a) and (b) is/are not present in its/their natural genetic environment or has/have been modified by 30 means of genetic manipulation methods, it being possible for the modification to be, by way of example, a substitution, addition, deletion, inversion or insertion of one or more nucleotide radicals. 0073.0.1 "Natural genetic environment" means the natural chromosomal locus in the organism of origin or the presence in a genomic library. In the case of a genomic 35 library, the natural, genetic environment of the nucleic acid sequence is preferably at least partially still preserved. The environment flanks the nucleic acid sequence at least on one side and has a sequence length of at least 50 bp, preferably at least 500 bp, particularly preferably at least 1000 bp, very particularly preferably at least 5000 bp. 0074.0.1 In said method for producing a transgenic plant comprising an SRP, the SRP coding nucleic acid is selected from the group comprising the nucleic acid of Fig. 5 la, lb or 1c and/or homologs of the afore mentioned sequences. Further, the SRP coding nucleic acid used in the said method is at least about 50% homologous to one of the nucleic acid of Fig. 1 a, 1b or 1 c. 0075.0.1 A plant or plant cell is considered "true breeding" for a particular trait if it is genetically homozygous for that trait to the extent that, when the true-breeding plant 10 is self-pollinated, a significant amount of independent segregation of the trait among the progeny is not observed. In the present invention, the trait arises from the transgenic expression of one or more DNA sequences introduced into a plant cell or plant. 0076.0.1 The present invention also provides methods of modifying stress 15 tolerance of a plant comprising, modifying the level of expression of a SRP nucleic acid in the plant. The invention provides one method of producing a transgenic plant with a synthetic, novel or modified transcription factor that acts by increasing the transcription of a SRP gene. Theoretically it is also possible to obtain a decrease in expression of the gene. 20 0077.0.1 A method of detecting environmental stress in plant cells or plants comprising screening the plant cells for altered metabolic activity as compared to non stress conditions is also in the scope of the invention. 0078.0.1 Further a method of screening plant cells or plants for increased tolerance and/or resistance to environmental stress comprising screening the plant 25 cells under stress conditions for altered metabolic activity as compared to non-stress conditions is encompassed in the invention. 0079.0.1 The present invention also encloses a method of breeding plant cells or plants towards increased tolerance and/or resistance to environmental stress comprising screening the plant cells under stress conditions for altered metabolic 30 activity as compared to non-stress conditions and selecting those with increased tolerance and/or resistance to environmental stress. 0080.0.1 In these methods metabolite activity is preferably altered concerning the above metabolites and groups of metabolites. 0081.0.1 The present invention also encompasses the use of altered metabolic 35 activity and/or a SRP encoding nucleic acid selected from the group comprising the nucleic acid of Fig. 1a, lb or 1c and/or homologs of the afore mentioned sequences or parts thereof as markers for selection of plants or plant cells with increased tolerance to environmental stress. 0082.0.1 The present invention further encompasses the use of altered metabolic activity and/or a SRP encoding nucleic acid selected from the group comprising the 5 nucleic acid of Fig. 1a, lb or 1c and/or homologs of the afore mentioned sequences or parts thereof as markers for detection of stress in plants or plant cells. 0083.0.1 The present invention also provides methods of modifying stress tolerance of a crop plant comprising utilizing a SRP coding nucleic acid sequence to identify individual plants in populations segregating for either increased or decreased 10 environmental stress tolerance (DNA marker). 0084.0.1 In the said method of modifying stress tolerance of a plant the SRP encoding nucleic acid may be selected from the group comprising the nucleic acid of Fig. 1 a, 1b or 1 c and/or homologs of the afore mentioned sequences. Further the SRP coding nucleic acid used therein may at least about 50% homologous to one of the 15 nucleic acid of Fig. 1a, 1b or 1c. Also an expression vector as described in the present invention might be used in the said method. 0085.0.1 In a variant method of said method of modifying stress tolerance, the plant is transformed with an inducible promoter that directs expression of the SRP. For example, the promoter is tissue specific. In a variant method, the used promoter is 20 developmentally regulated. 0086.0.2 In a further embodiment, the method of modifying stress tolerance comprises one or more of the following steps: a) stabilizing a protein conferring the increased expression of a protein encoded by the nucleic acid molecule of the invention or of the polypeptide 25 of the invention having the herein-mentioned activity of altering the metabolic activity; b) stabilizing a mRNA conferring the increased expression of a protein encoded by the nucleic acid molecule of the invention or its homologs or of a mRNA encoding the polypeptide of the present invention having the 30 herein-mentioned activity of altering the metabolic activity; c) increasing the specific activity of a protein conferring the increased expression of a protein encoded by the nucleic acid molecule of the invention or of the polypeptide of the present invention or decreasing the inhibitory regulation of the polypeptide of the invention; 35 d) generating or increasing the expression of an endogenous or artificial transcription factor mediating the expression of a protein conferring the increased expression of a protein encoded by the nucleic acid molecule of the invention or of the polypeptide of the invention having the herein mentioned activity of altering the metabolic activity; e) stimulating activity of a protein conferring the increased expression of a protein encoded by the nucleic acid molecule of the present invention or a 5 polypeptide of the present invention having the herein-mentioned activity of altering the metabolic activity by adding one or more exogenous inducing factors to the organisms or parts thereof; f) expressing a transgenic gene encoding a protein conferring the increased expression of a polypeptide encoded by the nucleic acid molecule of the 10 present invention or a polypeptide of the present invention, having the herein-mentioned activity of altering the metabolic activity; and/or g) increasing the copy number of a gene conferring the increased expression of a nucleic acid molecule encoding a polypeptide encoded by the nucleic acid molecule of the invention or the polypeptide of the invention having the 15 herein-mentioned activity of altering the metabolic activity; h) increasing the expression of the endogenous gene encoding the polypeptide of the invention or its homologs by adding positive expression or removing negative expression elements, e.g. homologous recombination can be used to either introduce positive regulatory elements like for plants 20 the 35S enhancer into the promoter or to remove repressor elements form regulatory regions. Further gene conversion methods can be used to disrupt repressor elements or to enhance to activity of positive elements positive elements can be randomly introduced in plants by T-DNA or transposon mutagenesis and lines can be identified in which the positive 25 elements have be integrated near to a gene of the invention, the expression of which is thereby enhanced; and/or i) modulating growth conditions of the plant in such a manner, that the expression or activity of the gene encoding the protein of the invention or 30 the protein itself is enhanced; j) selecting of organisms with especially high activity of the proteins of the invention from natural or from mutagenized resources and breeding them into the target organisms, eg the elite crops. 0087.0.2 Preferably, said mRNA is the nucleic acid molecule of the present 35 invention and/or the protein conferring the increased expression of a protein encoded by the nucleic acid molecule of the present invention or the polypeptide having the herein mentioned activity is the polypeptide of the present invention, e.g. conferring increased tolerance to environmental stress by altering the metabolic activity. 0088.0.2 In general, the amount of mRNA, polynucleotide or nucleic acid molecule in a cell or a compartment of an organism correlates with the amount of 5 encoded protein and thus with the overall activity of the encoded protein in said volume. Said correlation is not always linear, the activity in the volume is dependent on the stability of the molecules, the degradation of the molecules or the presence of activating or inhibiting co-factors. Further, product and educt inhibitions of enzymes are well known, e.g. Zinser et al. "Enzyminhibitoren / Enzyme inhibitors". 10 0089.0.2 The activity of the abovementioned proteins and/or polypeptide encoded by the nucleic acid molecule of the present invention can be increased in various ways. For example, the activity in an organism or in a part thereof, like a cell, is increased via increasing the gene product number, e.g. by increasing the expression rate, like introducing a stronger promoter, or by increasing the stability of the mRNA expressed, 15 thus increasing the translation rate, and/or increasing the stability of the gene product, thus reducing the proteins decayed. Further, the activity or turnover of enzymes can be influenced in such a way that a reduction or increase of the reaction rate or a modification (reduction or increase) of the affinity to the substrate results, is reached. A mutation in the catalytic centre of an polypeptide of the invention, e.g. as enzyme, can 20 modulate the turn over rate of the enzyme, e.g. a knock out of an essential amino acid can lead to a reduced or completely knock out activity of the enzyme, or the deletion or mutation of regulator binding sites can reduce a negative regulation like a feedback inhibition (or a substrate inhibition, if the substrate level is also increased). The specific activity of an enzyme of the present invention can be increased such that the turn over 25 rate is increased or the binding of a co-factor is improved. Improving the stability of the encoding mRNA or the protein can also increase the activity of a gene product. The stimulation of the activity is also under the scope of the term "increased activity". 0090.0.2 Moreover, the regulation of the abovementioned nucleic acid sequences may be modified so that gene expression is increased. This can be achieved 30 advantageously by means of heterologous regulatory sequences or by modifying, for example mutating, the natural regulatory sequences which are present. The advantageous methods may also be combined with each other. 0091.0.2 In general, an activity of a gene product in an organism or part thereof, in particular in a plant cell, a plant, or a plant tissue or a part thereof or in a 35 microorganism can be increased by increasing the amount of the specific encoding mRNA or the corresponding protein in said organism or part thereof. "Amount of protein or mRNA" is understood as meaning the molecule number of polypeptides or mRNA molecules in an organism, a tissue, a cell or a cell compartment. "Increase" in the amount of a protein means the quantitative increase of the molecule number of said protein in an organism, a tissue, a cell or a cell compartment or part thereof - for example by one of the methods described herein below - in comparison to a wild type, 5 control or reference. 0092.0.2 The increase in molecule number amounts preferably to at least 1%, preferably to more than 10%, more preferably to 30% or more, especially preferably to 50%, 70% or more, very especially preferably to 100%, most preferably to 500% or more. However, a de novo expression is also regarded as subject of the present 10 invention. 0093.0.2 A modification, i.e. an increase or decrease, can be caused by endogenous or exogenous factors. For example, an increase in activity in an organism or a part thereof can be caused by adding a gene product or a precursor or an activator or an agonist to the media or nutrition or can be caused by introducing said subjects 15 into a organism, transient or stable. 0094.0.2 In one embodiment the increase or decrease in metabolic activity in the plant or a part thereof, e.g. in a cell, a tissue, a organ, an organelle etc., is achieved by increasing the endogenous level of the polypeptide of the invention. Accordingly, in an embodiment of the present invention, the present invention relates to a process 20 wherein the gene copy number of a gene encoding the polynucleotide or nucleic acid molecule of the invention is increased. Further, the endogenous level of the polypeptide of the invention can for example be increased by modifying the transcriptional or translational regulation of the polypeptide. 0095.0.2 In one embodiment the metabolic activity in the plant or part thereof can 25 be altered by targeted or random mutagenesis of the endogenous genes of the invention. For example homologous recombination can be used to either introduce positive regulatory elements like for plants the 35S enhancer into the promoter or to remove repressor elements form regulatory regions. In addition gene conversion like methods described by Kochevenko and Willmitzer (Plant Physiol. 2003 30 May;132(1):174-84) and citations therein can be used to disrupt repressor elements or to enhance to activity of positive regulatory elements. Furthermore positive elements can be randomly introduced in (plant) genomes by T DNA or transposon mutagenesis and lines can be screened for, in which the positive elements has be integrated near to a gene of the invention, the expression of which is 35 thereby enhanced. The activation of plant genes by random integrations of enhancer elements has been described by Hayashi et al., 1992 (Science 258:1350-1353) or Weigel et al., 2000 (Plant Physiol. 122, 1003-1013) and others citied therein.

0096.0.2 Reverse genetic strategies to identify insertions (which eventually carrying the activation elements) near in genes of interest have been described for various cases eg. Krysan et al., 1999 (Plant Cell 1999, 11, 2283-2290); Sessions et al., 2002 (Plant Cell 2002, 14, 2985-2994); Young et al., 2001, (Plant Physiol. 2001, 125, 5 513-518); Koprek et al., 2000 (Plant J. 2000, 24, 253-263) ; Jeon et al., 2000 (Plant J. 2000, 22, 561-570) ; Tissier et al., 1999 (Plant Cell 1999, 11, 1841-1852); Speulmann et al., 1999 (Plant Cell 1999 ,11 , 1853-1866). Briefly material from all plants of a large T-DNA or transposon mutagenized plant population is harvested and genomic DNA prepared. Then the genomic DNA is pooled following specific architectures as 10 described for example in Krysan et al., 1999 (Plant Cell 1999, 11, 2283-2290). Pools of genomics DNAs are then screened by specific multiplex PCR reactions detecting the combination of the insertional mutagen (eg T-DNA or Transposon) and the gene of interest. Therefore PCR reactions are run on the DNA pools with specific combinations of T-DNA or transposon border primers and gene specific primers. General rules for 15 primer design can again be taken from Krysan et al., 1999 (Plant Cell 1999, 11, 2283 2290) Rescreening of lower levels DNA pools lead to the identification of individual plants in which the gene of interest is activated by the insertional mutagen. 0097.0.2 The enhancement of positive regulatory elements or the disruption or weaking of negative regulatory elements can also be achieved through common 20 mutagenesis techniques: The production of chemically or radiation mutated populations is a common technique and known to the skilled worker. Methods for plants are described by Koorneef et al. 1982 and the citations therein and by Lightner and Caspar in "Methods in Molecular Biology" Vol 82. These techniques usually induce point mutations that can be identified in any known gene using methods such as TILLING 25 (Colbert et al. 2001). 0098.0.2 Accordingly, the expression level can be increased if the endogenous genes encoding a polypeptide conferring an increased expression of the polypeptide of the present invention, in particular genes comprising the nucleic acid molecule of the present invention, are modified via homologous recombination, Tilling approaches or 30 gene conversion 0099.0.2 Regulatory sequences can be operatively linked to the coding region of an endogenous protein and control its transcription and translation or the stability or decay of the encoding mRNA or the expressed protein. In order to modify and control the expression, promoter, UTRs, splicing sites, processing signals, polyadenylation 35 sites, terminators, enhancers, repressors, post transcriptional or posttranslational modification sites can be changed, added or amended For example, the activation of plant genes by random integrations of enhancer elements has been described by Hayashi et al., 1992 (Science 258:1350-1353) or Weigel et al., 2000 (Plant Physiol. 122, 1003-1013) and others citied therein. For example, the expression level of the endogenous protein can be modulated by replacing the endogenous promoter with a stronger transgenic promoter or by replacing the endogenous 3'UTR with a 3'UTR, 5 which provides more stability without amending the coding region. Further, the transcriptional regulation can be modulated by introduction of a artificial transcription factor as described in the examples. Alternative promoters, terminators and UTRs are described below. 0100.0.2 The activation of an endogenous polypeptide having above-mentioned 10 activity, e.g. conferring an increased tolerance to environmental stress after altering the metabolic activity can also be increased by introducing a synthetic transcription factor, which binds close to the coding region of the protein of the invention encoding gene and activates its transcription. A chimeric zinc finger protein can be construed, which comprises a specific DNA-binding domain and an activation domain as e.g. the VP16 15 domain of Herpes Simplex virus. The specific binding domain can bind to the regulatory region of the protein coding region. The expression of the chimeric transcription factor in a plant leads to a specific expression of the protein of the invention, see e.g. in WOO1/52620, Oriz, Proc. NatI. Acad. Sci. USA, 2002, Vol. 99, 13290 or Guan, Proc. NatI. Acad. Sci. USA, 2002, Vol. 99, 13296. 20 0101.0.2 In one further embodiment of the method according to the invention, plants are used in which one of the abovementioned genes, or one of the abovementioned nucleic acids, is mutated in a way that the activity of the encoded gene products is less influenced by cellular factors, , or not at all, in comparison with the unmutated proteins. For example, well known regulation mechanism of enzymic 25 activity are substrate inhibition or feed back regulation mechanisms. Ways and techniques for the introduction of substitutions, deletions and additions of one or more bases, nucleotides or amino acids of a corresponding sequence are described herein below in the corresponding paragraphs and the references listed there, e.g. in Sambrook et al., Molecular Cloning, Cold Spring Habour, NY, 1989. The person skilled 30 in the art will be able to identify regulation domains and binding sites of regulators by comparing the sequence of the nucleic acid molecule of the present invention or the expression product thereof with the state of the art by computer software means which comprise algorithms for the identifying of binding sites and regulation domains or by introducing into a nucleic acid molecule or in a protein systematically mutations and 35 assaying for those mutations which will lead to an increased specificity activity or an increased activity per volume, in particular per cell.

0102.0.2 It is therefore advantageously to express in a plant a nucleic acid molecule of the invention or a polypeptide of the invention derived from a evolutionary distantly related organism, as e.g. using a prokaryotic gene in a eukaryotic host, as in these cases the regulation mechanism of the host cell may not weaken the activity 5 (cellular or specific) of the gene or its expression product 0103.0.2 The mutation is introduced in such a way that the production of the amino acids is not adversely affected.. 0104.0.2 Less influence on the regulation of a gene or its gene product is understood as meaning a reduced regulation of the enzymatic activity leading to an 10 increased specific or cellular activity of the gene or its product. An increase of the enzymatic activity is understood as meaning an enzymatic activity, which is increased by at least 10%, advantageously at least 20, 30 or 40%, especially advantageously by at least 50, 60 or 70% in comparison with the starting organism. 0105.0.1 The invention provides that the above methods can be performed such 15 that the stress tolerance is increased. It is also possible to obtain a decrease in stress tolerance. 0106.0.1 The invention is not limited to specific nucleic acids, specific polypeptides, specific cell types, specific host cells, specific conditions or specific methods etc. as such, but may vary and numerous modifications and variations therein 20 will be apparent to those skilled in the art. It is also to be understood that the terminology used herein is for the purpose of describing specific embodiments only and is not intended to be limiting. 0107.0.1 The present invention also relates to isolated Stress Related Proteins (SRP) which are selected from the group comprising the proteins of Fig. 1a, lb or 1c 25 and/or homologs thereof. Preferably, the isolated Stress Related Proteins (SRP) of the present invention are selected from yeast or E. coli. Further, the present invention is related to isolated Stress Related Protein (SRP) encoding nucleic acids selected from the group comprising the nucleic acid of Fig. la, lb or 1c and/or homologs thereof. Here, preferably, an isolated Stress Related Protein (SRP) encoding nucleic acid 30 encodes an SRP which is selected from yeast or E. coli. 0108.0.1 The present invention provides stress related gene sequences selected from the group consisting of the nucleic acid of Fig. 1a, lb or 1c of yeast, preferably from Saccharomyces cerevisiae or E. coli. 0109.0.1 Homologs of the aforementioned sequences can be isolated 35 advantageously from yeast, fungi, viruses, algae, bacteria, such as Acetobacter (subgen. Acetobacter) aceti; Acidithiobacillus ferrooxidans; Acinetobacter sp.; Actinobacillus sp; Aeromonas salmonicida; Agrobacterium tumefaciens; Aquifex aeolicus; Arcanobacterium pyogenes; Aster yellows phytoplasma; Bacillus sp.; Bifidobacterium sp.; Borrelia burgdorferi; Brevibacterium linens; Brucella melitensis; Buchnera sp.; Butyrivibrio fibrisolvens; Campylobacter jejuni; Caulobacter crescentus; Chlamydia sp.; Chlamydophila sp.; Chlorobium limicola; Citrobacter rodentium; 5 Clostridium sp.; Comamonas testosteroni; Corynebacterium sp.; Coxiella burnetii; Deinococcus radiodurans; Dichelobacter nodosus; Edwardsiella ictaluri; Enterobacter sp.; Erysipelothrix rhusiopathiae; Escherichia coli; Flavobacterium sp.; Francisella tularensis; Frankia sp. CpI 1; Fusobacterium nucleatum; Geobacillus stearothermophilus; Gluconobacter oxydans; Haemophilus sp.; Helicobacter pylori; 10 Klebsiella pneumoniae; Lactobacillus sp.; Lactococcus lactis; Listeria sp.; Mannheimia haemolytica; Mesorhizobium loti; Methylophaga thalassica; Microcystis aeruginosa; Microscilla sp. PRE1; Moraxella sp. TA144; Mycobacterium sp.; Mycoplasma sp.; Neisseria sp.; Nitrosomonas sp.; Nostoc sp. PCC 7120; Novosphingobium aromaticivorans; Oenococcus oeni; Pantoea citrea; Pasteurella multocida; 15 Pediococcus pentosaceus; Phormidium foveolarum; Phytoplasma sp.; Plectonema boryanum; Prevotella ruminicola; Propionibacterium sp.; Proteus vulgaris; Pseudomonas sp.; Ralstonia sp.; Rhizobium sp.; Rhodococcus equi; Rhodothermus marinus; Rickettsia sp.; Riemerella anatipestifer; Ruminococcus flavefaciens; Salmonella sp.; Selenomonas ruminantium; Serratia entomophila; Shigella sp.; 20 Sinorhizobium meliloti; Staphylococcus sp.; Streptococcus sp.; Streptomyces sp.; Synechococcus sp.; Synechocystis sp. PCC 6803; Thermotoga maritima; Treponema sp.; Ureaplasma urealyticum; Vibrio cholerae; Vibrio parahaemolyticus; Xylella fastidiosa; Yersinia sp.; Zymomonas mobilis, preferably Salmonella sp. or Escherichia coli or plants, preferably from yeasts such as from the genera Saccharomyces, Pichia, 25 Candida, Hansenula, Torulopsis or Schizosaccharomyces or plants such as Arabidopsis thaliana, maize, wheat, rye, oat, triticale, rice, barley, soybean, peanut, cotton, borage, sufflower, linseed, primrose, rapeseed, canola and turnip rape, manihot, pepper, sunflower, tagetes, solanaceous plant such as potato, tobacco, eggplant and tomato, Vicia species, pea, alfalfa, bushy plants such as coffee, cacao, 30 tea, Salix species, trees such as oil palm, coconut, perennial grass, such as ryegrass and fescue, and forage crops, such as alfalfa and clover and from spruce, pine or fir for example. More preferably homologs of aforementioned sequences can be isolated from Saccharomyces cerevisiae, E. coli or plants, preferably Brassica napus, Glycine max, or Oryza sativa. 35 0110.0.1 The stress related proteins of the present invention are preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the protein is cloned into an expression vector, for example in to a binary vector, the expression vector is introduced into a host cell, for example the Arabidopsis thaliana wild type NASC N906 or any other plant cell as described in the examples see below, and the stress related protein is expressed in said host cell. Examples for binary vectors are pBIN19, pBI101, pBinAR, pGPTV, pCAMBIA, pBIB-HYG, pBecks, 5 pGreen or pPZP (Hajukiewicz, P. et al., 1994, Plant Mol. Biol., 25: 989-994 and Hellens et al, Trends in Plant Science (2000) 5, 446-451.). 0111.0.1 Advantageously, the nucleic acid sequences according to the invention or the gene construct together with at least one reporter gene are cloned into an expression cassette, which is introduced into the organism via a vector or directly into 10 the genome. This reporter gene should allow easy detection via a growth, fluorescence, chemical, bioluminescence or resistance assay or via a photometric measurement. Examples of reporter genes which may be mentioned are antibiotic- or herbicide-resistance genes, hydrolase genes, fluorescence protein genes, bioluminescence genes, sugar or nucleotide metabolic genes or biosynthesis genes 15 such as the Ura3 gene, the llv2 gene, the luciferase gene, the p-galactosidase gene, the gfp gene, the 2-desoxyglucose-6-phosphate phosphatase gene, the . p glucuronidase gene, p-lactamase gene, the neomycin phosphotransferase gene, the hygromycin phosphotransferase gene or the BASTA (= gluphosinate-resistance) gene. These genes permit easy measurement and quantification of the transcription activity 20 and hence of the expression of the genes. In this way genome positions may be identified which exhibit differing productivity. 0112.0.1 In a preferred embodiment a nucleic acid contruct, for example an expression cassette, comprises upstream, i.e. at the 5' end of the encoding sequence, a promoter and downstream, i.e. at the 3' end, a polyadenylation signal and optionally 25 other regulatory elements which are operably linked to the intervening encoding sequence with the nucleic acid of Fig. 1 a, 1b or 1 c. By an operable linkage is meant the sequential arrangement of promoter, encoding sequence, terminator and optionally other regulatory elements in such a way that each of the regulatory elements can fulfill its function in the expression of the encoding sequence in due manner. The sequences 30 preferred for operable linkage are targeting sequences for ensuring subcellular localization in plastids. However, targeting sequences for ensuring subcellular localization in the mitochondrium, in the endoplasmic reticulum (= ER), in the nucleus, in oil corpuscles or other compartments may also be employed as well as translation promoters such as the 5' lead sequence in tobacco mosaic virus (Gallie et al., Nucl. 35 Acids Res. 15 (1987), 8693 -8711). 0113.0.1 A nucleic acid construct, for example an expression cassette may, for example, contain a constitutive promoter or a tissue-specific promoter (preferably the USP or napin promoter) the gene to be expressed and the ER retention signal. For the ER retention signal the KDEL amino acid sequence (lysine, aspartic acid, glutamic acid, leucine) or the KKX amino acid sequence (lysine-lysine-X-stop, wherein X means every other known amino acid) is preferably employed. 5 0114.0.1 For expression in a prokaryotic or eukaryotic host organism, for example a microorganism such as a fungus or a plant the expression cassette is advantageously inserted into a vector such as by way of example a plasmid, a phage or other DNA which allows optimum expression of the genes in the host organism. Examples of suitable plasmids are: in E. coli pLG338, pACYC184, pBR series such as 10 e.g. pBR322, pUC series such as pUC18 or pUC19, M113mp series, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-111 113 -B1, Agtl1 or pBdCI; in Streptomyces plJ101, pIJ364, pIJ702 or pIJ361; in Bacillus pUB110, pC194 or pBD214; in Corynebacterium pSA77 or pAJ667; in fungi pALS1, pIL2 or pBB116; other advantageous fungal vectors are described by Romanos, M.A. et al., [(1992) ,,Foreign 15 gene expression in yeast: a review", Yeast 8: 423-488] and by van den Hondel, C.A.M.J.J. et al. [(1991) ,Heterologous gene expression in filamentous fungi" as well as in More Gene Manipulations in Fungi [J.W. Bennet & L.L. Lasure, eds., pp. 396-428: Academic Press: San Diego] and in ,,Gene transfer systems and vector development for filamentous fungi" [van den Hondel, C.A.M.J.J. & Punt, P.J. (1991) in: Applied 20 Molecular Genetics of Fungi, Peberdy, J.F. et al., eds., pp. 1-28, Cambridge University Press: Cambridge]. Examples of advantageous yeast promoters are 2pM, pAG-1, YEp6, YEp13 or pEMBLYe23. Examples of algal or plant promoters are pLGV23, pGHlac*, pBIN19, pAK2004, pVKH or pDH51 (see Schmidt, R. and Willmitzer, L., 1988). The vectors identified above or derivatives of the vectors identified above are a 25 small selection of the possible plasmids. Further plasmids are well known to those skilled in the art and may be found, for example, in the book Cloning Vectors (Eds. Pouwels P.H. et al. Elsevier, Amsterdam-New York-Oxford, 1985 ISBN 0 444 904018). Suitable plant vectors are described inter alia in ,,Methods in Plant Molecular Biology and Biotechnology" (CRC Press), Ch. 6/7, pp. 71-119. 30 Advantageous vectors are known as shuttle vectors or binary vectors which replicate in E. coli and Agrobacterium. 0115.0.1 By vectors is meant with the exception of plasmids all other vectors known to those skilled in the art such as by way of example phages, viruses such as SV40, CMV, baculovirus, adenovirus, transposons, IS elements, phasmids, 35 phagemids, cosmids, linear or circular DNA. These vectors can be replicated autonomously in the host organism or be chromosomally replicated, chromosomal replication being preferred.

0116.0.1 In a further embodiment of the vector the expression cassette according to the invention may also advantageously be introduced into the organisms in the form of a linear DNA and be integrated into the genome of the host organism by way of heterologous or homologous recombination. This linear DNA may be composed of a 5 linearized plasmid or only of the expression cassette as vector or the nucleic acid sequences according to the invention. 0117.0.1 In a further advantageous embodiment the nucleic acid sequence according to the invention can also be introduced into an organism on its own. 0118.0.1 If in addition to the nucleic acid sequence according to the invention 10 further genes are to be introduced into the organism, all together with a reporter gene in a single vector or each single gene with a reporter gene in a vector in each case can be introduced into the organism, whereby the different vectors can be introduced simultaneously or successively. 0119.0.1 The vector advantageously contains at least one copy of the nucleic acid 15 sequences according to the invention and/or the expression cassette (= gene construct) according to the invention. 0120.0.3 The invention further provides an isolated recombinant expression vector comprising a SRP nucleic acid as described above, wherein expression of the vector in a host cell results in increased tolerance to environmental stress as compared 20 to a wild type variety of the host cell. As used herein, the term "vector" refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a "plasmid," which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. 25 Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are 30 capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as "expression vectors." In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, "plasmid" and "vector" can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such 35 other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses, and adeno-associated viruses), which serve equivalent functions.

0121.0.3 The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is 5 operatively linked to the nucleic acid sequence to be expressed. As used herein with respect to a recombinant expression vector, "operatively linked" is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner which allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system or in a host cell when the vector is introduced into the 10 host cell). The term "regulatory sequence" is intended to include promoters, enhancers, and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, CA (1990) and Gruber and Crosby, in: Methods in Plant Molecular Biology and Biotechnology, eds. 15 Glick and Thompson, Chapter 7, 89-108, CRC Press: Boca Raton, Florida, including the references therein. Regulatory sequences include those that direct constitutive expression of a nucleotide sequence in many types of host cells and those that direct expression of the nucleotide sequence only in certain host cells or under certain conditions. It will be appreciated by those skilled in the art that the design of the 20 expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of polypeptide desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce polypeptides or peptides, including fusion polypeptides or peptides, encoded by nucleic acids as described herein (e.g., SRPs, mutant forms of SRPs, fusion polypeptides, 25 etc.). 0122.0.3 The recombinant expression vectors of the invention can be designed for expression of SRPs in prokaryotic or eukaryotic cells. For example, SRP genes can be expressed in bacterial cells such as C. glutamicum, insect cells (using baculovirus expression vectors), yeast and other fungal cells (See Romanos, M.A. et al., 1992, 30 Foreign gene expression in yeast: a review, Yeast 8:423-488; van den Hondel, C.A.M.J.J. et al., 1991, Heterologous gene expression in filamentous fungi, in: More Gene Manipulations in Fungi, J.W. Bennet & L.L. Lasure, eds., p. 396-428: Academic Press: San Diego; and van den Hondel, C.A.M.J.J. & Punt, P.J., 1991, Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics 35 of Fungi, Peberdy, J.F. et al., eds., p. 1-28, Cambridge University Press: Cambridge), algae (Falciatore et al., 1999, Marine Biotechnology 1(3):239-251), ciliates of the types: Holotrichia, Peritrichia, Spirotrichia, Suctoria, Tetrahymena, Paramecium, Colpidium, Glaucoma, Platyophrya, Potomacus, Pseudocohnilembus, Euplotes, Engelmaniella, and Stylonychia, especially of the genus Stylonychia lemnae with vectors following a transformation method as described in PCT Application No. WO 98/01572, and multicellular plant cells (See Schmidt, R. and Willmitzer, L., 1988, High efficiency 5 Agrobacterium tumefaciens-mediated transformation of Arabidopsis thaliana leaf and cotyledon explants, Plant Cell Rep. 583-586; Plant Molecular Biology and Biotechnology, C Press, Boca Raton, Florida, chapter 6/7, S.71-119 (1993); F.F. White, B. Jenes et al., Techniques for Gene Transfer, in: Transgenic Plants, Vol. 1, Engineering and Utilization, eds. Kung und R. Wu, 128-43, Academic Press: 1993; 10 Potrykus, 1991, Annu. Rev. Plant Physiol. Plant Molec. Biol. 42:205-225 and references cited therein) or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press: San Diego, CA (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory 15 sequences and T7 polymerase. 0123.0.3 Expression of polypeptides in prokaryotes is most often carried out with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion polypeptides. Fusion vectors add a number of amino acids to a polypeptide encoded therein, usually to the amino terminus of the recombinant 20 polypeptide but also to the C-terminus or fused within suitable regions in the polypeptides. Such fusion vectors typically serve three purposes: 1) to increase expression of a recombinant polypeptide; 2) to increase the solubility of a recombinant polypeptide; and 3) to aid in the purification of a recombinant polypeptide by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage 25 site is introduced at the junction of the fusion moiety and the recombinant polypeptide to enable separation of the recombinant polypeptide from the fusion moiety subsequent to purification of the fusion polypeptide. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin, and enterokinase. 0124.0.1 By way of example the plant expression cassette can be installed in the 30 pRT transformation vector ((a) Toepfer et al., 1993, Methods Enzymol., 217: 66-78; (b) Toepfer et al. 1987, Nucl. Acids. Res. 15: 5890 ff.). 0125.0.1 Alternatively, a recombinant vector (= expression vector) can also be transcribed and translated in vitro, e.g. by using the T7 promoter and the T7 RNA polymerase. 35 0126.0.1 Expression vectors employed in prokaryotes frequently make use of inducible systems with and without fusion proteins or fusion oligopeptides, wherein these fusions can ensue in both N-terminal and C-terminal manner or in other useful domains of a protein. Such fusion vectors usually have the following purposes: i.) to increase the RNA expression rate; ii.) to increase the achievable protein synthesis rate; iii.) to increase the solubility of the protein; iv.) or to simplify purification by means of a binding sequence usable for affinity chromatography. Proteolytic cleavage points are 5 also frequently introduced via fusion proteins, which allow cleavage of a portion of the fusion protein and purification. Such recognition sequences for proteases are recognized, e.g. factor Xa, thrombin and enterokinase. 0127.0.1 Typical advantageous fusion and expression vectors are pGEX [Pharmacia Biotech Inc; Smith, D.B. and Johnson, K.S. (1988) Gene 67: 31-40], pMAL 10 (New England Biolabs, Beverly, MA) and pRIT5 (Pharmacia, Piscataway, NJ) which contains glutathione S-transferase (GST), maltose binding protein or protein A. 0128.0.3 In one embodiment, the coding sequence of the SRP is cloned into a pGEX expression vector to create a vector encoding a fusion polypeptide comprising, from the N-terminus to the C-terminus, GST-thrombin cleavage site-X polypeptide. The 15 fusion polypeptide can be purified by affinity chromatography using glutathione agarose resin. Recombinant PKSRP unfused to GST can be recovered by cleavage of the fusion polypeptide with thrombin. 0129.0.1 Other examples of E. coli expression vectors are pTrc [Amann et al., (1988) Gene 69:301-315] and pET vectors [Studier et al., Gene Expression 20 Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 60-89; Stratagene, Amsterdam, The Netherlands]. 0130.0.3 Target gene expression from the pTrc vector relies on host RNA polymerase transcription from a hybrid trp-lac fusion promoter. Target gene expression from the pET 11d vector relies on transcription from a T7 gn10-lac fusion promoter 25 mediated by a co-expressed viral RNA polymerase (T7 gnl). This viral polymerase is supplied by host strains BL21(DE3) or HMS174(DE3) from a resident X prophage harboring a T7 gnl gene under the transcriptional control of the lacUV 5 promoter. 0131.0.3 One strategy to maximize recombinant polypeptide expression is to express the polypeptide in a host bacteria with an impaired capacity to proteolytically 30 cleave the recombinant polypeptide (Gottesman, S., Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, California (1990) 119-128). Another strategy is to alter the sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in the bacterium chosen for expression, such as C. glutamicum 35 (Wada et al., 1992, Nucleic Acids Res. 20:2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.

0132.0.1 Other advantageous vectors for use in yeast are pYepSecl (Baldari, et al., (1987) Embo J. 6:229-234), pMFa (Kurjan and Herskowitz, (1982) Cell 30:933 943), pJRY88 (Schultz et al., (1987) Gene 54:113-123), and pYES derivatives (Invitrogen Corporation, San Diego, CA). Vectors for use in filamentous fungi are 5 described in: van den Hondel, C.A.M.J.J. & Punt, P.J. (1991) ,Gene transfer systems and vector development for filamentous fungi", in: Applied Molecular Genetics of Fungi, J.F. Peberdy, et al., eds., pp. 1-28, Cambridge University Press: Cambridge. 0133.0.1 Alternatively, insect cell expression vectors can also be advantageously utilized, e.g. for expression in Sf 9 cells. These are e.g. the vectors of the pAc series 10 (Smith et al. (1983) Mol. Cell Biol. 3:2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170:31-39). 0134.0.1 Furthermore, plant cells or algal cells can advantageously be used for gene expression. Examples of plant expression vectors may be found in Becker, D., et al. (1992) ,,New plant binary vectors with selectable markers located proximal to the left 15 border", Plant Mol. Biol. 20: 1195-1197 orin Bevan, M.W. (1984) ,Binary Agrobacterium vectors for plant transformation", Nucl. Acid. Res. 12: 8711-8721. 0135.0.1 Furthermore, the nucleic acid sequences may also be expressed in mammalian cells, advantageously in nonhuman mammalian cells. Examples of corresponding expression vectors are pCDM8 and pMT2PC referred to in: Seed, B. 20 (1987) Nature 329:840 or Kaufman et al. (1987) EMBO J. 6: 187-195). At the same time promoters preferred for use are of viral origin, such as by way of example promoters of polyoma, adenovirus 2, cytomegalovirus or simian virus 40. Other prokaryotic and eukaryotic expression systems are referred to in chapters 16 and 17 of Sambrook et al., Molecular Cloning: A Laboratory Manual. 2nd, ed., Cold Spring 25 Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989. 0136.0.3 In a preferred embodiment of the present invention, the SRPs are expressed in plants and plants cells such as unicellular plant cells (e.g. algae) (See Falciatore et al., 1999, Marine Biotechnology 1(3):239-251 and references therein) and 30 plant cells from higher plants (e.g., the spermatophytes, such as crop plants). A SRP may be "introduced" into a plant cell by any means, including transfection, transformation or transduction, electroporation, particle bombardment, agroinfection, and the like. One transformation method known to those of skill in the art is the dipping of a flowering plant into an Agrobacteria solution, wherein the Agrobacteria contains 35 the SRP nucleic acid, followed by breeding of the transformed gametes. 0137.0.3 Other suitable methods for transforming or transfecting host cells including plant cells can be found in Sambrook, et al., Molecular Cloning: A Laboratory Manual. 2 nd, ed., Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989, and other laboratory manuals such as Methods in Molecular Biology, 1995, Vol. 44, Agrobacterium protocols, ed: Gartland and Davey, Humana Press, Totowa, New Jersey. As biotic and abiotic stress tolerance is a 5 general trait wished to be inherited into a wide variety of plants like maize, wheat, rye, oat, triticale, rice, barley, soybean, peanut, cotton, rapeseed and canola, manihot, pepper, sunflower and tagetes, solanaceous plants like potato, tobacco, eggplant, and tomato, Vicia species, pea, alfalfa, bushy plants (coffee, cacao, tea), Salix species, trees (oil palm, coconut), perennial grasses, and forage crops, these crop plants are 10 also preferred target plants for a genetic engineering as one further embodiment of the present invention. Forage crops include, but are not limited to, Wheatgrass, Canarygrass, Bromegrass, Wildrye Grass, Bluegrass, Orchardgrass, Alfalfa, Salfoin, Birdsfoot Trefoil, Alsike Clover, Red Clover, and Sweet Clover. 0138.0.3 In one embodiment of the present invention, transfection of a SRP into a 15 plant is achieved by Agrobacterium mediated gene transfer. Agrobacterium mediated plant transformation can be performed using for example the GV3101(pMP90) (Koncz and Schell, 1986, Mol. Gen. Genet. 204:383-396) or LBA4404 (Clontech) Agrobacterium tumefaciens strain. Transformation can be performed by standard transformation and regeneration techniques (Deblaere et al., 1994, Nucl. Acids Res. 20 13:4777-4788; Gelvin, Stanton B. and Schilperoort, Robert A, Plant Molecular Biology Manual, 2 nd Ed. - Dordrecht : Kluwer Academic Publ., 1995. - in Sect., Ringbuc Zentrale Signatur: BT11-P ISBN 0-7923-2731-4; Glick, Bernard R.; Thompson, John E., Methods in Plant Molecular Biology and Biotechnology, Boca Raton : CRC Press, 1993 360 S., ISBN 0-8493-5164-2). For example, rapeseed can be transformed via 25 cotyledon or hypocotyl transformation (Moloney et al., 1989, Plant cell Report 8:238 242; De Block et al., 1989, Plant Physiol. 91:694-701). Use of antibiotics for Agrobacterium and plant selection depends on the binary vector and the Agrobacterium strain used for transformation. Rapeseed selection is normally performed using kanamycin as selectable plant marker. ,Agrobacterium mediated gene 30 transfer to flax can be performed using, for example, a technique described by Mlynarova et al., 1994, Plant Cell Report 13:282-285. Additionally, transformation of soybean can be performed using for example a technique described in European Patent No. 0424 047, U.S. Patent No. 5,322,783, European Patent No. 0397 687, U.S. Patent No. 5,376,543, or U.S. Patent No. 5,169,770. Transformation of maize can be 35 achieved by particle bombardment, polyethylene glycol mediated DNA uptake or via the silicon carbide fiber technique. (See, for example, Freeling and Walbot "The maize handbook" Springer Verlag: New York (1993) ISBN 3-540-97826-7). A specific n~ A example of maize transformation is found in U.S. Patent No. 5,990,387, and a specific example of wheat transformation can be found in PCT Application No. WO 93/07256. 0139.0.3 According to the present invention, the introduced SRP may be maintained in the plant cell stably if it is incorporated into a non-chromosomal 5 autonomous replicon or integrated into the plant chromosomes. Alternatively, the introduced SRP may be present on an extra-chromosomal non-replicating vector and be transiently expressed or transiently active. 0140.0.3 In one embodiment, a homologous recombinant microorganism can be created wherein the SRP is integrated into a chromosome, a vector is prepared which 10 contains at least a portion of a SRP gene into which a deletion, addition, or substitution has been introduced to thereby alter, e.g., functionally disrupt, the SRP gene. Preferably, the SRP gene is a yeast, E.coli, Brassica napus, Glycine max, or Oryza sativa SRP gene, but it can be a homolog from a related plant or even from a mammalian or insect source. In one embodiment, the vector is designed such that, 15 upon homologous recombination, the endogenous SRP gene is functionally disrupted (i.e., no longer encodes a functional polypeptide; also referred to as a knock-out vector). Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous SRP gene is mutated or otherwise altered but still encodes a functional polypeptide (e.g., the upstream regulatory region can be altered 20 to thereby alter the expression of the endogenous SRP). To create a point mutation via homologous recombination, DNA-RNA hybrids can be used in a technique known as chimeraplasty (Cole-Strauss et al., 1999, Nucleic Acids Research 27(5):1323-1330 and Kmiec, 1999 Gene therapy American Scientist. 87(3):240-247). Homologous recombination procedures in Physcomitrella patens are also well known in the art and 25 are contemplated for use herein. 0141.0.3 Whereas in the homologous recombination vector, the altered portion of the SRP gene is flanked at its 5' and 3' ends by an additional nucleic acid molecule of the SRP gene to allow for homologous recombination to occur between the exogenous SRP gene carried by the vector and an endogenous SRP gene, in a microorganism or 30 plant. The additional flanking SRP nucleic acid molecule is of sufficient length for successful homologous recombination with the endogenous gene. Typically, several hundreds of base pairs up to kilobases of flanking DNA (both at the 5' and 3' ends) are included in the vector. See, e.g., Thomas, K.R., and Capecchi, M.R., 1987, Cell 51:503 for a description of homologous recombination vectors or Strepp et al., 1998, 35 PNAS, 95 (8):4368-4373 for cDNA based recombination in Physcomitrella patens). The vector is introduced into a microorganism or plant cell (e.g., via polyethylene glycol mediated DNA), and cells in which the introduced PKSRP gene has homologously recombined with the endogenous PKSRP gene are selected using art-known techniques. 0142.0.3 In another embodiment, recombinant microorganisms can be produced that contain selected systems which allow for regulated expression of the introduced 5 gene. For example, inclusion of a SRP gene on a vector placing it under control of the lac operon permits expression of the SRP gene only in the presence of IPTG. Such regulatory systems are well known in the art. 0143.0.3 Whether present in an extra-chromosomal non-replicating vector or a vector that is integrated into a chromosome, the SRP polynucleotide preferably resides 10 in a plant expression cassette. A plant expression cassette preferably contains regulatory sequences capable of driving gene expression in plant cells that are operatively linked so that each sequence can fulfill its function, for example, termination of transcription by polyadenylation signals. Preferred polyadenylation signals are those originating from Agrobacterium tumefaciens t-DNA such as the gene 3 known as 15 octopine synthase of the Ti-plasmid pTiACH5 (Gielen et al., 1984, EMBO J. 3:835) or functional equivalents thereof but also all other terminators functionally active in plants are suitable. As plant gene expression is very often not limited on transcriptional levels, a plant expression cassette preferably contains other operatively linked sequences like translational enhancers such as the overdrive-sequence containing the 20 5'-untranslated leader sequence from tobacco mosaic virus enhancing the polypeptide per RNA ratio (Gallie et al., 1987, Nucl. Acids Research 15:8693-8711). Examples of plant expression vectors include those detailed in: Becker, D. et al., 1992, New plant binary vectors with selectable markers located proximal to the left border, Plant Mol. Biol. 20: 1195-1197; and Bevan, M.W., 1984, Binary Agrobacterium vectors for plant 25 transformation, Nucl. Acid. Res. 12:8711-8721; and Vectors for Gene Transfer in Higher Plants; in: Transgenic Plants, Vol. 1, Engineering and Utilization, eds.: Kung and R. Wu, Academic Press, 1993, S. 15-38. 0144.0.1 "Transformation" is defined herein as a process for introducing heterologous DNA into a plant cell, plant tissue, or plant. It may occur under natural or 30 artificial conditions using various methods well known in the art. Transformation may rely on any known method for the insertion of foreign nucleic acid sequences into aprokaryotic or eukaryotic host cell. The method is selected based on the host cell being transformed and may include, but is not limited to, viral infection, electroporation, lipofection, and particle bombardment. Such "transformed" cells include stably 35 transformed cells in which the inserted DNA is capable of replication either as an autonomously replicating plasmid or as part of the host chromosome. They also include cells which transiently express the inserted DNA or RNA for limited periods of time.

Transformed plant cells, plant tissue, or plants are understood to encompass not only the end product of a transformation process, but also transgenic progeny thereof. 0145.0.1 The terms "transformed," "transgenic," and "recombinant" refer to a host organism such as a bacterium or a plant into which a heterologous nucleic acid 5 molecule has been introduced. The nucleic acid molecule can be stably integrated into the genome of the host or the nucleic acid molecule can also be present as an extrachromosomal molecule. Such an extrachromosomal molecule can be auto replicating. Transformed cells, tissues, or plants are understood to encompass not only the end product of a transformation process, but also transgenic progeny thereof. A 10 "non-transformed," "non-transgenic," or "non-recombinant" host refers to a wild-type organism, e.g., a bacterium or plant, which does not contain the heterologous nucleic acid molecule. 0146.0.1 A "transgenic plant", as used herein, refers to a plant which contains a foreign nucleotide sequence inserted into either its nuclear genome or organellar 15 genome. It encompasses further the offspring generations i.e. the T1-, T2- and consecutively generations or BC1-, BC2- and consecutively generation as well as crossbreeds thereof with non-transgenic or other transgenic plants. 0147.0.1 The host organism (= transgenic organism) advantageously contains at least one copy of the nucleic acid according to the invention and/or of the nucleic acid 20 construct according to the invention. 0148.0.2 In principle all plants can be used as host organism. Preferred transgenic plants are, for example, selected from the families Aceraceae, Anacardiaceae, Apiaceae, Asteraceae, Brassicaceae, Cactaceae, Cucurbitaceae, Euphorbiaceae, Fabaceae, Malvaceae, Nymphaeaceae, Papaveraceae, Rosaceae, 25 Salicaceae, Solanaceae, Arecaceae, Bromeliaceae, Cyperaceae, Iridaceae, Liliaceae, Orchidaceae, Gentianaceae, Labiaceae, Magnoliaceae, Ranunculaceae, Carifolaceae, Rubiaceae, Scrophulariaceae, Caryophyllaceae, Ericaceae, Polygonaceae, Violaceae, Juncaceae or Poaceae and preferably from a plant selected from the group of the families Apiaceae, Asteraceae, Brassicaceae, Cucurbitaceae, Fabaceae, 30 Papaveraceae, Rosaceae, Solanaceae, Liliaceae or Poaceae. Preferred are crop plants such as plants advantageously selected from the group of the genus peanut, oilseed rape, canola, sunflower, safflower, olive, sesame, hazelnut, almond, avocado, bay, pumpkin/squash, linseed, soya, pistachio, borage, maize, wheat, rye, oats, sorghum and millet, triticale, rice, barley, cassava, potato, sugarbeet, egg plant, alfalfa, 35 and perennial grasses and forage plants, oil palm, vegetables (brassicas, root vegetables, tuber vegetables, pod vegetables, fruiting vegetables, onion vegetables, leafy vegetables and stem vegetables), buckwheat, Jerusalem artichoke, broad bean, vetches, lentil, dwarf bean, lupin, clover and Lucerne for mentioning only some of them. 0149.0.2 In one prefered embodiment, the host plant is selected from the families Aceraceae, Anacardiaceae, Apiaceae, Asteraceae, Brassicaceae, Cactaceae, 5 Cucurbitaceae, Euphorbiaceae, Fabaceae, Malvaceae, Nymphaeaceae, Papaveraceae, Rosaceae, Salicaceae, Solanaceae, Arecaceae, Bromeliaceae, Cyperaceae, Iridaceae, Liliaceae, Orchidaceae, Gentianaceae, Labiaceae, Magnoliaceae, Ranunculaceae, Carifolaceae, Rubiaceae, Scrophulariaceae, Caryophyllaceae, Ericaceae, Polygonaceae, Violaceae, Juncaceae or Poaceae and 10 preferably from a plant selected from the group of the families Apiaceae, Asteraceae, Brassicaceae, Cucurbitaceae, Fabaceae, Papaveraceae, Rosaceae, Solanaceae, Liliaceae or Poaceae. Preferred are crop plants and in particular plants mentioned herein above as host plants such as the families and genera mentioned above for example preferred the species Anacardium occidentale, Calendula officinalis, 15 Carthamus tinctorius, Cichorium intybus, Cynara scolymus, Helianthus annus, Tagetes lucida, Tagetes erecta, Tagetes tenuifolia; Daucus carota; Corylus avellana, Corylus colurna, Borago officinalis; Brassica napus, Brassica rapa ssp., Sinapis arvensis Brassica juncea, Brassica juncea var. juncea, Brassica juncea var. crispifolia, Brassica juncea var. foliosa, Brassica nigra, Brassica sinapioides, Melanosinapis communis, 20 Brassica oleracea, Arabidopsis thaliana, Anana comosus, Ananas ananas, Bromelia comosa, Carica papaya, Cannabis sative, Ipomoea batatus, Ipomoea pandurata, Convolvulus batatas, Convolvulus tiliaceus, Ipomoea fastigiata, Ipomoea tiliacea, Ipomoea triloba, Convolvulus panduratus, Beta vulgaris, Beta vulgaris var. altissima, Beta vulgaris var. vulgaris, Beta maritima, Beta vulgaris var. perennis, Beta vulgaris 25 var. conditiva, Beta vulgaris var. esculenta, Cucurbita maxima, Cucurbita mixta, Cucurbita pepo, Cucurbita moschata, Olea europaea, Manihot utilissima, Janipha manihot,, Jatropha manihot., Manihot aipil, Manihot dulcis, Manihot manihot, Manihot melanobasis, Manihot esculenta, Ricinus communis, Pisum sativum, Pisum arvense, Pisum humile, Medicago sativa, Medicago falcata, Medicago varia, Glycine max 30 Dolichos soja, Glycine gracilis, Glycine hispida, Phaseolus max, Soja hispida, Soja max, Cocos nucifera, Pelargonium grossularioides, Oleum cocoas, Laurus nobilis, Persea americana, Arachis hypogaea, Linum usitatissimum, Linum humile, Linum austriacum, Linum bienne, Linum angustifolium, Linum catharticum, Linum flavum, Linum grandiflorum, Adenolinum grandiflorum, Linum lewisii, Linum narbonense, Linum 35 perenne, Linum perenne var. lewisii, Linum pratense, Linum trigynum, Punica granatum, Gossypium hirsutum, Gossypium arboreum, Gossypium barbadense, Gossypium herbaceum, Gossypium thurberi, Musa nana, Musa acuminata, Musa paradisiaca, Musa spp., Elaeis guineensis, Papaver orientale, Papaver rhoeas, Papaver dubium, Sesamum indicum, Piper aduncum, Piper amalago, Piper angustifolium, Piper auritum, Piper betel, Piper cubeba, Piper longum, Piper nigrum, Piper retrofractum, Artanthe adunca, Artanthe elongata, Peperomia elongata, Piper 5 elongatum, Steffensia elongata, , Hordeum vulgare, Hordeum jubatum, Hordeum murinum, Hordeum secalinum, Hordeum distichon Hordeum aegiceras, Hordeum hexastichon., Hordeum hexastichum, Hordeum irregulare, Hordeum sativum, Hordeum secalinum, Avena sativa, Avena fatua, Avena byzantina, Avena fatua var. sativa, Avena hybrida, Sorghum bicolor, Sorghum halepense, Sorghum saccharatum, 10 Sorghum vulgare, Andropogon drummondii, Holcus bicolor, Holcus sorghum, Sorghum aethiopicum, Sorghum arundinaceum, Sorghum caffrorum, Sorghum cernuum, Sorghum dochna, Sorghum drummondii, Sorghum durra, Sorghum guineense, Sorghum lanceolatum, Sorghum nervosum, Sorghum saccharatum, Sorghum subglabrescens, Sorghum verticilliflorum, Sorghum vulgare, Holcus halepensis, 15 Sorghum miliaceum millet, Panicum militaceum, Zea mays, Triticum aestivum, Triticum durum, Triticum turgidum, Triticum hybernum, Triticum macha, Triticum sativum or Triticum vulgare, Cofea spp., Coffea arabica, Coffea canephora, Coffea liberica, Capsicum annuum, Capsicum annuum var. glabriusculum, Capsicum frutescens, Capsicum annuum, Nicotiana tabacum, Solanum tuberosum, Solanum melongena, 20 Lycopersicon esculentum, Lycopersicon lycopersicum., Lycopersicon pyriforme, Solanum integrifolium, Solanum lycopersicum Theobroma cacao or Camellia sinensis. 0150.0.2 Anacardiaceae such as the genera Pistacia, Mangifera, Anacardium e.g. the species Pistacia vera [pistachios, Pistazie], Mangifer indica [Mango] or Anacardium occidentale [Cashew]; Asteraceae such as the genera Calendula, Carthamus, Centaurea, 25 Cichorium, Cynara, Helianthus, Lactuca, Locusta, Tagetes, Valeriana e.g. the species Calendula officinalis [Marigold], Carthamus tinctorius [safflower], Centaurea cyanus [cornflower], Cichorium intybus [blue daisy], Cynara scolymus [Artichoke], Helianthus annus [sunflower], Lactuca sativa, Lactuca crispa, Lactuca esculenta, Lactuca scariola L. ssp. sativa, Lactuca scariola L. var. integrata, Lactuca scariola L. var. integrifolia, 30 Lactuca sativa subsp. romana, Locusta communis, Valeriana locusta [lettuce], Tagetes lucida, Tagetes erecta or Tagetes tenuifolia [Marigold]; Apiaceae such as the genera Daucus e.g. the species Daucus carota [carrot]; Betulaceae such as the genera Corylus e.g. the species Corylus avellana or Corylus colurna [hazelnut]; Boraginaceae such as the genera Borago e.g. the species Borago officinalis [borage]; Brassicaceae such as the 35 genera Brassica, Melanosinapis, Sinapis, Arabadopsis e.g. the species Brassica napus, Brassica rapa ssp. [canola, oilseed rape, turnip rape], Sinapis arvensis Brassicajuncea, n,% Brassica juncea var. juncea, Brassica juncea var. crispifolia, Brassica juncea var. foliosa, Brassica nigra, Brassica sinapioides, Melanosinapis communis [mustard], Brassica oleracea [fodder beet] or Arabidopsis thaliana; Bromeliaceae such as the genera Anana, Bromelia e.g. the species Anana comosus, Ananas ananas or Bromelia 5 comosa [pineapple]; Caricaceae such as the genera Carica e.g. the species Carica papaya [papaya]; Cannabaceae such as the genera Cannabis e.g. the species Cannabis sative [hemp], Convolvulaceae such as the genera Ipomea, Convolvulus e.g. the species Ipomoea batatus, Ipomoea pandurata, Convolvulus batatas, Convolvulus tiliaceus, Ipomoea fastigiata, Ipomoea tiliacea, Ipomoea triloba or Convolvulus panduratus 10 [sweet potato, Man of the Earth, wild potato], Chenopodiaceae such as the genera Beta, i.e. the species Beta vulgaris, Beta vulgaris var. altissima, Beta vulgaris var. Vulgaris, Beta maritima, Beta vulgaris var. perennis, Beta vulgaris var. conditiva or Beta vulgaris var. esculenta [sugar beet]; Cucurbitaceae such as the genera Cucubita e.g. the species Cucurbita maxima, Cucurbita mixta, Cucurbita pepo or Cucurbita moschata [pumpkin, 15 squash]; Elaeagnaceae such as the genera Elaeagnus e.g. the species Olea europaea [olive]; Ericaceae such as the genera Kalmia e.g. the species Kalmia latifolia, Kalmia angustifolia, Kalmia microphylla, Kalmia polifolia, Kalmia occidentalis, Cistus chamaerhodendros or Kalmia lucida [American laurel, broad-leafed laurel, calico bush, spoon wood, sheep laurel, alpine laurel, bog laurel, western bog-laurel, swamp-laurel]; 20 Euphorbiaceae such as the genera Manihot, Janipha, Jatropha, Ricinus e.g. the species Manihot utilissima, Janipha manihot,, Jatropha manihot., Manihot aipil, Manihot dulcis, Manihot manihot, Manihot melanobasis, Manihot esculenta [manihot, arrowroot, tapioca, cassava] or Ricinus communis [castor bean, Castor Oil Bush, Castor Oil Plant, Palma Christi, Wonder Tree]; Fabaceae such as the genera Pisum, Albizia, Cathormion, 25 Feuillea, Inga, Pithecolobium, Acacia, Mimosa, Medicajo, Glycine, Dolichos, Phaseolus, Soja e.g. the species Pisum sativum, Pisum arvense, Pisum humile [pea], Albizia berteriana, Albizia julibrissin, Albizia lebbeck, Acacia berteriana, Acacia littoralis, Albizia berteriana, Albizzia berteriana, Cathormion berteriana, Feuillea berteriana, Inga fragrans, Pithecellobium berterianum, Pithecellobium fragrans, 30 Pithecolobium berterianum, Pseudalbizzia berteriana, Acacia julibrissin, Acacia nemu, Albizia nemu, Feuilleea julibrissin, Mimosa julibrissin, Mimosa speciosa, Sericanrda julibrissin, Acacia lebbeck, Acacia macrophylla, Albizia lebbek, Feuilleea lebbeck, Mimosa lebbeck, Mimosa speciosa [bastard logwood, silk tree, East Indian Walnut], Medicago sativa, Medicago falcata, Medicago varia [alfalfa] Glycine max Dolichos 35 soja, Glycine gracilis, Glycine hispida, Phaseolus max, Soja hispida or Soja max [soybean]; Geraniaceae such as the genera Pelargonium, Cocos, Oleum e.g. the species Cocos nucifera, Pelargonium grossularioides or Oleum cocois [coconut]; Gramineae such as the genera Saccharum e.g. the species Saccharum officinarum; Juglandaceae such as the genera Juglans, Wallia e.g. the species Juglans regia, Juglans ailanthifolia, 5 Juglans sieboldiana, Juglans cinerea, Wallia cinerea, Juglans bixbyi, Juglans californica, Juglans hindsii, Juglans intermedia, Juglans jamaicensis, Juglans major, Juglans microcarpa, Juglans nigra or Wallia nigra [walnut, black walnut, common walnut, persian walnut, white walnut, butternut, black walnut]; Lauraceae such as the genera Persea, Laurus e.g. the species laurel Laurus nobilis [bay, laurel, bay laurel, 10 sweet bay], Persea americana Persea americana, Persea gratissima or Persea persea [avocado]; Leguminosae such as the genera Arachis e.g. the species Arachis hypogaea [peanut]; Linaceae such as the genera Linum, Adenolinum e.g. the species Linum usitatissimum, Linum humile, Linum austriacum, Linum bienne, Linum angustifolium, Linum catharticum, Linum flavum, Linum grandiflorum, Adenolinum grandiflorum, 15 Linum lewisii, Linum narbonense, Linum perenne, Linum perenne var. Jewisii, Linum pratense or Linum trigynum [flax, linseed]; Lythrarieae such as the genera Punica e.g. the species Punica granatum [pomegranate]; Malvaceae such as the genera Gossypium e.g. the species Gossypium hirsutum, Gossypium arboreum, Gossypium barbadense, Gossypium herbaceum or Gossypium thurberi [cotton]; Musaceae such as the genera 20 Musa e.g. the species Musa nana, Musa acuminata, Musa paradisiaca, Musa spp. [banana]; Onagraceae such as the genera Camissonia, Oenothera e.g. the species Oenothera biennis or Camissonia brevipes [primrose, evening primrose]; Palmae such as the genera Elacis e.g. the species Elaeis guineensis [oil plam]; Papaveraceae such as the genera Papaver e.g. the species Papaver orientale, Papaver rhoeas, Papaver dubium 25 [poppy, oriental poppy, corn poppy, field poppy, shirley poppies, field poppy, long headed poppy, long-pod poppy]; Pedaliaceae such as the genera Sesamum e.g. the species Sesamum indicum [sesame]; Piperaceae such as the genera Piper, Artanthe, Peperomia, Steffensia e.g. the species Piper aduncum, Piper amalago, Piper angustifolium, Piper auritum, Piper betel, Piper cubeba, Piper longum, Piper nigrum, 30 Piper retrofractum, Artanthe adunca, Artanthe elongata, Peperomia elongata, Piper elongatum, Steffensia elongata. [Cayenne pepper, wild pepper]; Poaceae such as the genera Hordeum, Secale, Avena, Sorghum, Andropogon, Holcus, Panicum, Oryza, Zea, Triticum e.g. the species Hordeum vulgare, Hordeum jubatum, Hordeum murinum, Hordeum secalinum, Hordeum distichon Hordeum aegiceras, Hordeum hexastichon., Hordeum hexastichum, Hordeum irregulare, Hordeum sativum, Hordeum secalinum [barley, pearl barley, foxtail barley, wall barley, meadow barley], Secale cereale [rye], Avena sativa, Avena fatua, Avena byzantina, Avena fatua var. sativa, Avena hybrida [oat], Sorghum bicolor, Sorghum halepense, Sorghum saccharatum, Sorghum vulgare, 5 Andropogon drummondii, Holcus bicolor, Holcus sorghum, Sorghum aethiopicum, Sorghum arundinaceum, Sorghum caffrorum, Sorghum cernuum, Sorghum dochna, Sorghum drummondii, Sorghum durra, Sorghum guineense, Sorghum lanceolatum, Sorghum nervosum, Sorghum saccharatum, Sorghum subglabrescens, Sorghum verticilliflorum, Sorghum vulgare, Holcus halepensis, Sorghum miliaceum millet, 10 Panicum militaceum [Sorghum, millet], Oryza sativa, Oryza latifolia [rice], Zea mays [corn, maize] Triticum aestivum, Triticum durum, Triticum turgidum, Triticum hybernum, Triticum macha, Triticum sativum or Triticum vulgare [wheat, bread wheat, common wheat], Proteaceae such as the genera Macadamia e.g. the species Macadamia intergrifolia [macadamia]; Rubiaceae such as the genera Coffea e.g. the species Cofea 15 spp., Coffea arabica, Coffea canephora or Coffea liberica [coffee]; Scrophulariaceae such as the genera Verbascum e.g. the species Verbascum blattaria, Verbascum chaixii, Verbascum densiflorum, Verbascum lagurus, Verbascum longifolium, Verbascum lychnitis, Verbascum nigrum, Verbascum olympicum, Verbascum phlomoides, Verbascum phoenicum, Verbascum pulverulentum or Verbascum thapsus [mullein, 20 white moth mullein, nettle-leaved mullein, dense-flowered mullein, silver mullein, long leaved mullein, white mullein, dark mullein, greek mullein, orange mullein, purple mullein, hoary mullein, great mullein]; Solanaceae such as the genera Capsicum, Nicotiana, Solanum, Lycopersicon e.g. the species Capsicum annuum, Capsicum annuum var. glabriusculum, Capsicum frutescens [pepper], Capsicum annuum 25 [paprika], Nicotiana tabacum, Nicotiana alata, Nicotiana attenuata, Nicotiana glauca, Nicotiana langsdorffii, Nicotiana obtusifolia, Nicotiana quadrivalvis, Nicotiana repanda, Nicotiana rustica, Nicotiana sylvestris [tobacco], Solanum tuberosum [potato], Solanum melongena [egg-plant] (Lycopersicon esculentum, Lycopersicon lycopersicum., Lycopersicon pyriforme, Solanum integrifolium or Solanum 30 lycopersicum [tomato]; Sterculiaceae such as the genera Theobroma e.g. the species Theobroma cacao [cacao]; Theaceae such as the genera Camellia e.g. the species Camellia sinensis) [tea]. 0151.0.1 The introduction of the nucleic acids according to the invention, the expression cassette or the vector into organisms, plants for example, can in principle be done by all of the methods known to those skilled in the art. The introduction of the nucleic acid sequences gives rise to recombinant or transgenic organisms. 0152.0.1 In the case of microorganisms, those skilled in the art can find appropriate methods in the textbooks by Sambrook, J. et al. (1989) Molecular cloning: 5 A laboratory manual, Cold Spring Harbor Laboratory Press, by F.M. Ausubel et al. (1994) Current protocols in molecular biology, John Wiley and Sons, by D.M. Glover et al., DNA Cloning Vol.1, (1995), IRL Press (ISBN 019-963476-9), by Kaiser et al. (1994) Methods in Yeast Genetics, Cold Spring Harbor Laboratory Press or Guthrie et al. Guide to Yeast Genetics and Molecular Biology, Methods in Enzymology, 1994, 10 Academic Press. 0153.0.1 The transfer of foreign genes into the genome of a plant is called transformation. In doing this the methods described for the transformation and regeneration of plants from plant tissues or plant cells are utilized for transient or stable transformation. Suitable methods are protoplast transformation by poly(ethylene 15 glycol)-induced DNA uptake, the ,biolistic" method using the gene cannon - referred to as the particle bombardment method, electroporation, the incubation of dry embryos in DNA solution, microinjection and gene transfer mediated by Agrobacterium. Said methods are described by way of example in B. Jenes et al., Techniques for Gene Transfer, in: Transgenic Plants, Vol. 1, Engineering and Utilization, eds. S.D. Kung and 20 R. Wu, Academic Press (1993) 128-143 and in Potrykus Annu. Rev. Plant Physiol. Plant Molec. Biol. 42 (1991) 205-225). The nucleic acids or the construct to be expressed is preferably cloned into a vector which is suitable for transforming Agrobacterium tumefaciens, for example pBin19 (Bevan et al., Nucl. Acids Res. 12 (1984) 8711). Agrobacteria transformed by such a vector can then be used in known 25 manner for the transformation of plants, in particular of crop plants such as by way of example tobacco plants, for example by bathing bruised leaves or chopped leaves in an agrobacterial solution and then culturing them in suitable media. The transformation of plants by means of Agrobacterium tumefaciens is described, for example, by Hbfgen and Willmitzer in Nucl. Acid Res. (1988) 16, 9877 or is known inter alia from F.F. White, 30 Vectors for Gene Transfer in Higher Plants; in Transgenic Plants, Vol. 1, Engineering and Utilization, eds. S.D. Kung and R. Wu, Academic Press, 1993, pp. 15-38. 0154.0.1 Agrobacteria transformed by an expression vector according to the invention may likewise be used in known manner for the transformation of plants such as test plants like Arabidopsis or crop plants such as cereal crops, corn, oats, rye, 35 barley, wheat, soybean, rice, cotton, sugar beet, canola, sunflower, flax, hemp, potatoes, tobacco, tomatoes, carrots, paprika, oilseed rape, tapioca, cassava, arrowroot, tagetes, alfalfa, lettuce and the various tree, nut and vine species, in particular of oil-containing crop plants such as soybean, peanut, castor oil plant, sunflower, corn, cotton, flax, oilseed rape, coconut, oil palm, safflower (Carthamus tinctorius) or cocoa bean, e.g. by bathing bruised leaves or chopped leaves in an agrobacterial solution and then culturing them in suitable media. 5 0155.0.1 The genetically modified plant cells may be regenerated by all of the methods known to those skilled in the art. Appropriate methods can be found in the publications referred to above by S.D. Kung and R. Wu, Potrykus or Hbfgen and Willmitzer. 0156.0.1 Accordingly, a further aspect of the invention relates to transgenic 10 organisms transformed by at least one nucleic acid sequence, expression cassette or vector according to the invention as well as cells, cell cultures, tissue, parts - such as, for example, leaves, roots, etc. in the case of plant organisms - or reproductive material derived from such organisms. The terms ,,host organism", ,,host cell", ,,recombinant (host) organism" and ,,transgenic (host) cell" are used here 15 interchangeably. Of course these terms relate not only to the particular host organism or the particular target cell but also to the descendants or potential descendants of these organisms or cells. Since, due to mutation or environmental effects certain modifications may arise in successive generations, these descendants need not necessarily be identical with the parental cell but nevertheless are still encompassed by 20 the term as used here. 0157.0.1 For the purposes of the invention ,,transgenic" or ,,recombinant" means with regard for example to a nucleic acid sequence, an expression cassette (= gene construct, nucleic acid construct) or a vector containing the nucleic acid sequence according to the invention or an organism transformed by the nucleic acid sequences, 25 expression cassette or vector according to the invention all those constructions produced by genetic engineering methods in which either a) the nucleic acid sequence depicted in Fig. 1a, lb or 1c or its derivatives or parts thereof or b) a genetic control sequence functionally linked to the nucleic acid 30 sequence described under (a), for example a 3'- and/or 5'- genetic control sequence such as a promoter or terminator, or c) (a) and (b) are not found in their natural, genetic environment or have been modified by genetic engineering methods, wherein the modification may by way of example be a 35 substitution, addition, deletion, inversion or insertion of one or more nucleotide residues. Natural genetic environment means the natural genomic or chromosomal locus in the organism of origin or inside the host organism or presence in a genomic library. In the case of a genomic library the natural genetic environment of the nucleic acid sequence is preferably retained at least in part. The environment borders the nucleic acid sequence at least on one side and has a sequence length of at least 50 bp, preferably at least 500 bp, particularly preferably at least 1,000 bp, most particularly 5 preferably at least 5,000 bp. A naturally occurring expression cassette - for example the naturally occurring combination of the natural promoter of the nucleic acid sequence according to the invention with the corresponding A-8-desaturase, A-9 elongase and/or A-5-desaturase gene - turns into a transgenic expression cassette when the latter is modified by unnatural, synthetic (,,artificial") methods such as by way 10 of example a mutagenation. Appropriate methods are described by way of example in US 5,565,350 or WO 00/15815. 0158.0.1 Suitable organisms or host organisms for the nucleic acid, expression cassette or vector according to the invention are advantageously in principle all organisms, which are suitable for the expression of recombinant genes as described 15 above. Further examples which may be mentioned are plants such as Arabidopsis, Asteraceae such as Calendula or crop plants such as soybean, peanut, castor oil plant, sunflower, flax, corn, cotton, flax, oilseed rape, coconut, oil palm, safflower (Carthamus tinctorius) or cocoa bean. 0159.0.1 A further object of the invention relates to the use of a nucleic acid 20 construct, e.g. an expression cassette, containing DNA sequences encoding polypeptides of Fig. la, lb or 1c or DNA sequences hybridizing therewith for the transformation of plant cells, tissues or parts of plants. 0160.0.1 In doing so, depending on the choice of promoter, the sequences Fig. la, lb or 1c can be expressed specifically in the leaves, in the seeds, the nodules, in 25 roots, in the stem or other parts of the plant. Those transgenic plants overproducing sequences of Fig. 1a, 1b or ic, the reproductive material thereof, together with the plant cells, tissues or parts thereof are a further object of the present invention. 0161.0.1 The expression cassette or the nucleic acid sequences or construct according to the invention containing sequences of Fig. la, lb or 1c can, moreover, 30 also be employed for the transformation of the organisms identified by way of example above such as bacteria, yeasts, filamentous fungi and plants. 0162.0.1 Within the framework of the present invention, altering metabolic activity means, for example, the artificially acquired trait of increased biosynthetic performance due to functional over expression of sequences of Fig. la, lb or 1c in the organisms 35 according to the invention, advantageously in the transgenic plants according to the invention, by comparison with the nongenetically modified initial plants at least for the duration of at least one plant generation.

0163.0.1 A constitutive expression of the exogenous sequences of the Fig. 1a, 1b or 1c is, moreover, advantageous. On the other hand, however, an inducible expression may also appear desirable. 0164.0.1 The efficiency of the expression of the sequences of the Fig. 1a, 1b or 5 1c can be determined, for example, in vitro by shoot meristem propagation. In addition, an expression of the sequences of Fig. 1 a, 1b or 1 c modified in nature and level and its effect on the metabolic pathways performance can be tested on test plants in greenhouse trials. 0165.0.1 An additional object of the invention comprises transgenic organisms 10 such as transgenic plants transformed by an expression cassette containing sequences of Fig. la, lb or 1c according to the invention or DNA sequences hybridizing therewith, as well as transgenic cells, tissue, parts and reproduction material of such plants. Particular preference is given in this case to transgenic crop plants such as by way of example barley, wheat, rye, oats, corn, soybean, rice, cotton, 15 sugar beet, oilseed rape and canola, sunflower, flax, hemp, thistle, potatoes, tobacco, tomatoes, tapioca, cassava, arrowroot, alfalfa, lettuce and the various tree, nut and vine species. 0166.0.1 For the purposes of the invention plants are mono- and dicotyledonous plants, mosses or algae. 20 0167.0.1 A further refinement according to the invention are transgenic plants as described above which contain a nucleic acid sequence or construct according to the invention or a expression cassette according to the invention. 0168.0.1 Furthermore, by derivatives is meant homologues of the sequences of Fig. la, lb or 1c, for example eukaryotic homologues, truncated sequences, single 25 stranded DNA of the encoding and nonencoding DNA sequence or RNA of the encoding and nonencoding DNA sequence. 0169.0.1 In addition, by homologues of the sequences of Fig. la, lb or 1c is meant derivatives such as by way of example promoter variants. These variants may be modified by one or more nucleotide exchanges, by insertion(s) and/or deletion(s) 30 without, however, adversely affecting the functionality or efficiency of the promoters. Furthermore, the promoters can have their efficiency increased by altering their sequence or be completely replaced by more effective promoters even of foreign organisms. 0170.0.1 By derivatives is also advantageously meant variants whose nucleotide 35 sequence has been altered in the region from -1 to -2000 ahead of the start codon in such a way that the gene expression and/or the protein expression is modified, preferably increased. Furthermore, by derivatives is also meant variants which have been modified at the 3' end. 0171.0.1 Suitable promoters in the expression cassette are in principle all promoters which can control the expression of foreign genes in organisms such as 5 microorganisms like protozoa such as ciliates, algae such as green, brown, red or blue algae such as Euglenia, bacteria such as gram-positive or gram-negative bacteria, yeasts such as Saccharomyces, Pichia or Schizosaccharomyces or fungi such as Mortierella, Thraustochytrium or Schizochytrium or plants, advantageously in plants or fungi. Use is preferably made in particular of plant promoters or promoters derived from 10 a plant virus. Advantageous regulation sequences for the method according to the invention are found for example in promoters such as cos, tac, trp, tet, trp-tet, Ipp, lac, Ipp-lac, laclq-, T7, T5, T3, gal, trc, ara, SP6, A-PR or in A-PL promoters which are employed advantageously in gram-negative bacteria. Other advantageous regulation sequences are found, for example, in the gram-positive promoters amy and SP02, in 15 the yeast or fungal promoters ADC1, MFa, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH or in the plant promoters CaMV/35S [Franck et al., Cell 21(1980) 285-294], SSU, OCS, lib4, STLS1, B33, nos (= Nopalin Synthase Promoter) or in the ubiquintin or phaseolin promoter. The expression cassette may also contain a chemically inducible promoter by means of which the expression of the exogenous sequences of the odd numbers of 20 SEQ. ID No. 1-269 in the organisms can be controlled advantageously in the plants at a particular time. Advantageous plant promoters of this type are by way of example the PRP1 promoter [Ward et al., Plant.Mol. Biol.22(1993), 361-366], a promoter inducible by benzenesulfonamide (EP 388 186), a promoter inducible by tetracycline [Gatz et al., (1992) Plant J. 2,397-404], a promoter inducible by salicylic acid (WO 95/19443), a 25 promoter inducible by abscisic acid (EP 335 528) and a promoter inducible by ethanol or cyclohexanone (WO93/21334). Other examples of plant promoters which can advantageously be used are the promoter of cytosolic FBPase from potato, the ST-LSI promoter from potato (Stockhaus et al., EMBO J. 8 (1989) 2445-245), the promoter of phosphoribosyl pyrophosphate amidotransferase from Glycine max (see also gene 30 bank accession number U87999) or a nodiene-specific promoter as described in EP 249 676. Particularly advantageous are those plant promoters which ensure expression in tissues or plant parts/organs in which fatty acid biosynthesis or the precursor stages thereof occurs, as in endosperm or in the developing embryo for example. Particularly noteworthy are advantageous promoters which ensure seed 35 specific expression such as by way of example the USP promoter or derivatives thereof, the LEB4 promoter, the phaseolin promoter or the napin promoter. The particularly advantageous USP promoter cited according to the invention or its derivatives mediate very early gene expression in seed development [Baeumlein et al., Mol Gen Genet, 1991, 225 (3): 459-67]. Other advantageous seed-specific promoters which may be used for monocotylodonous or dicotylodonous plants are the promoters suitable for dicotylodons such as napin gene promoters, likewise cited by way of 5 example, from oilseed rape (US 5,608,152), the oleosin promoter from Arabidopsis (WO 98/45461), the phaseolin promoter from Phaseolus vulgaris (US 5,504,200), the Bce4 promoter from Brassica (WO 91/13980) or the leguminous B4 promoter (LeB4, Baeumlein et al., Plant J., 2, 2, 1992: 233 - 239) or promoters suitable for monocotylodons such as the promoters of the Ipt2 or Ipt1 gene in barley (WO 95/15389 10 and WO 95/23230) or the promoters of the barley hordeine gene, the rice glutelin gene, the rice oryzin gene, the rice prolamin gene, the wheat gliadin gene, the white glutelin gene, the corn zein gene, the oats glutelin gene, the sorghum kasirin gene or the rye secalin gene which are described in WO99/16890. 0172.0.1 Furthermore, particularly preferred are those promoters, which ensure 15 the expression in tissues, or plant parts in which, for example, the biosynthesis of fatty acids, oils and lipids or the precursor stages thereof takes place. Particularly noteworthy are promoters, which ensure a seed-specific expression. Noteworthy are the promoter of the napin gene from oilseed rape (US 5,608,152), the USP promoter from Vicia faba (USP = unknown seed protein, Baeumlein et al., Mol Gen Genet, 1991, 20 225 (3): 459-67), the promoter of the oleosin gene from Arabidopsis (WO98/45461), the phaseolin promoter (US 5,504,200) or the promoter of the legumin B4 gene (LeB4; Baeumlein et al., 1992, Plant Journal, 2 (2): 233-9). Other promoters to be mentioned are that of the Ipt2 or Ipt1 gene from barley (WO95/15389 and WO95/23230) which mediate seed-specific expression in monocotyledonous plants. Other advantageous 25 seed specific promoters are promoters such as the promoters from rice, corn or wheat disclosed in WO 99/16890 or Amy32b, Amy6-6 or aleurain (US 5,677,474), Bce4 (rape, US 5,530,149), glycinin (soy bean, EP 571 741), phosphoenol pyruvat carboxylase (soy bean, JP 06/62870), ADR12-2 (soy bean, WO 98/08962), isocitratlyase (rape, US 5,689,040) or p-amylase (barley, EP 781 849). 30 0173.0.1 As described above, the expression construct (= gene construct, nucleic acid construct) may contain yet other genes, which are to be introduced into the organisms. These genes can be subject to separate regulation or be subject to the same regulation region as sequences Fig. 1a, lb or 1c. These genes are by way of example other biosynthesis genes, advantageously for fatty acid biosynthesis, vitamin 35 biosynthesis etc. that allow increased synthesis. 0174.0.1 In principle all natural promoters with their regulation sequences can be used like those named above for the expression cassette according to the invention and the method according to the invention. Over and above this, synthetic promoters may also advantageously be used. 0175.0.1 In the preparation of an expression cassette various DNA fragments can be manipulated in order to obtain a nucleotide sequence, which usefully reads in the 5 correct direction and is equipped with a correct reading raster. To connect the DNA fragments (= nucleic acids according to the invention) to one another adaptors or linkers may be attached to the fragments. 0176.0.1 The promoter and the terminator regions can usefully be provided in the transcription direction with a linker or polylinker containing one or more restriction 10 points for the insertion of this sequence. Generally, the linker has 1 to 10, mostly 1 to 8, preferably 2 to 6, restriction points. In general the size of the linker inside the regulatory region is less than 100 bp, frequently less than 60 bp, but at least 5 bp. The promoter may be both native or homologous as well as foreign or heterologous to the host organism, for example to the host plant. In the 5'-3' transcription direction the 15 expression cassette contains the promoter, a DNA sequence which encodes of Fig. 1a, lb or 1c gene and a region for transcription termination. Different termination regions can be exchanged for one another in any desired fashion. 0177.0.1 Furthermore, manipulations which provide suitable restriction interfaces or which remove excess DNA or restriction interfaces can be employed. Where 20 insertions, deletions or substitutions, such as transitions and transversions, come into consideration, in vitro mutagenesis, primer repair, restriction or ligation may be used. In suitable manipulations such as restriction, chewing back or filling of overhangs for blunt ends complementary ends of the fragments can be provided for the ligation. 0178.0.1 For an advantageous high expression the attachment of the specific ER 25 retention signal SEKDEL inter alia can be of importance (Schouten, A. et al., Plant Mol. Biol. 30 (1996), 781-792). In this way the average expression level is tripled or even quadrupled. Other retention signals which occur naturally in plant and animal proteins located in the ER may also be employed for the construction of the cassette. In another preferred embodiment a plastidial targeting sequence is used as described by Napier 30 J.A. [Targeting of foreign proteins to the chloroplast, Methods Mol. Biol., 49, 1995: 369 - 376]. A preferred used vector comprising said plastidial targeting sequence is disclosed by Colin Lazarus [Guerineau F., Woolston S., Brooks L., Mullineaux P. "An expression cassette for targeting foreign proteins into chloroplast; Nucleic. Acids Res., Dec 9, 16 (23), 1988: 11380]. 35 0179.0.1 Preferred polyadenylation signals are plant polyadenylation signals, preferably those which substantially correspond to T-DNA polyadenylation signals from Agrobacterium tumefaciens, in particular gene 3 of the T-DNA (octopin synthase) of the Ti plasmid pTiACH5 (Gielen et al., EMBO J.3 (1984), 835 et seq.) or corresponding functional equivalents. 0180.0.1 An expression cassette is produced by fusion of a suitable promoter with suitable sequences of Fig. la, lb or 1c together with a polyadenylation signal by 5 common recombination and cloning techniques as described, for example, in T. Maniatis, E.F. Fritsch and J. Sambrook, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1989) as well as in T.J. Silhavy, M.L. Berman and L.W. Enquist, Experiments with Gene Fusions, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (1984) and in Ausubel, F.M. et al., Current 10 Protocols in Molecular Biology, Greene Publishing Assoc. and Wiley-Interscience (1987). 0181.0.1 In the preparation of an expression cassette various DNA fragments can be manipulated to produce a nucleotide sequence which usefully reads in the correct direction and is equipped with a correct reading raster. Adapters or linkers can be 15 attached to the fragments for joining the DNA fragments. 0182.0.1 The promoter and the terminator regions can usefully be provided in the transcription direction with a linker or polylinker containing one or more restriction points for the insertion of this sequence. Generally, the linker has 1 to 10, mostly 1 to 8, preferably 2 to 6, restriction points. In general the size of the linker inside the regulatory 20 region is less than 100 bp, frequently less than 60 bp, but at least 5 bp. The promoter may be both native or homologous as well as foreign or heterologous to the host organism, for example to the host plant. In the 5'-3' transcription direction the expression cassette contains the promoter, a DNA sequence which either encodes gene of the odd numbers of SEQ. ID No. 1-269 and a region for transcription 25 termination. Different termination regions can be exchanged for one another in any desired fashion. 0183.0.1 In the preparation of an expression cassette various DNA fragments can be manipulated to produce a nucleotide sequence which usefully reads in the correct direction and is equipped with a correct reading raster. Adapters or linkers can be 30 attached to the fragments for joining the DNA fragments. 0184.0.1 The DNA sequences encoding the nucleic acid sequences used in the inventive processes such as the sequences of the Fig. 1a, lb or 1c contain all the sequence characteristics needed to achieve correct localization of respective biosynthesis. Accordingly, no further targeting sequences are needed per se. However, 35 such a localization may be desirable and advantageous and hence artificially modified or reinforced so that such fusion constructs are also a preferred advantageous embodiment of the invention.

0185.0.1 Particularly preferred are sequences which ensure targeting in plastids. Under certain circumstances targeting into other compartments (reported in: Kermode, Crit. Rev. Plant Sci. 15, 4 (1996), 285-423) may also be desirable, e.g. into vacuoles, the mitochondrium, the endoplasmic reticulum (ER), peroxisomes, lipid structures or 5 due to lack of corresponding operative sequences retention in the compartment of origin, the cytosol. 0186.0.1 As used herein, the term "environmental stress" refers to any sub optimal growing condition and includes, but is not limited to, sub-optimal conditions associated with salinity, drought, temperature, metal, chemical, pathogenic and 10 oxidative stresses, or combinations thereof. In preferred embodiments, the environmental stress can be salinity, drought, heat, or low temperature, or combinations thereof, and in particular, can be low water content or low temperature. Wherein drought stress means any environmental stress which leads to a lack of water in plants or reduction of water supply to plants, wherein low temperature stress means 15 freezing of plants below + 4 'C as well as chilling of plants below 15 'C and wherein high temperature stress means for example a temperature above 35 'C. The range of stress and stress response depends on the different plants which are used for the invention, i.e. it differs for example between a plant such as wheat and a plant such as Arabidopsis. A common response of plants to environmental stress is the loss of yield 20 or the loss of quality. It is also to be understood that as used in the specification and in the claims, "a" or "an" can mean one or more, depending upon the context in which it is used. Thus, for example, reference to "a cell" can mean that at least one cell can be utilized. 0187.0.1 As also used herein, the terms "nucleic acid" and "nucleic acid molecule" 25 are intended to include DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules (e.g., mRNA) and analogs of the DNA or RNA generated using nucleotide analogs. This term also encompasses untranslated sequence located at both the 3' and 5' ends of the coding region of the gene: at least about 1000 nucleotides of sequence upstream from the 5' end of the coding region and at least about 200 30 nucleotides of sequence downstream from the 3' end of the coding region of the gene. The nucleic acid molecule can be single-stranded or double-stranded, but preferably is double-stranded DNA. 0188.0.1 An "isolated" nucleic acid molecule is one that is substantially separated from other nucleic acid molecules, which are present in the natural source of the 35 nucleic acid. That means other nucleic acid molecules are present in an amount less than 5% based on weight of the amount of the desired nucleic acid, preferably less than 2% by weight, more preferably less than 1% by weight, most preferably less than 0.5% by weight. Preferably, an "isolated" nucleic acid is free of some of the sequences that naturally flank the nucleic acid (i.e., sequences located at the 5' and 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated stress related protein 5 encoding nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived. Moreover, an "isolated" nucleic acid molecule, such as a cDNA molecule, can be free from some of the other cellular material with which it is naturally associated, or culture medium 10 when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. 0189.0.1 A nucleic acid molecule of the present invention, e.g., a nucleic acid molecule encoding an SRP or a portion thereof which confers tolerance and/or resistance to environmental stress in plants, can be isolated using standard molecular 15 biological techniques and the sequence information provided herein. For example, a Arabidopsis thaliana stress related protein encoding cDNA can be isolated from a A. thaliana c-DNA library using all or portion of one of the sequences of Fig. 1a, lb or 1c. Moreover, a nucleic acid molecule encompassing all or a portion of one of the sequences of Fig. 1a, lb or 1c can be isolated by the polymerase chain reaction using 20 oligonucleotide primers designed based upon this sequence. For example, mRNA can be isolated from plant cells (e.g., by the guanidinium-thiocyanate extraction procedure of Chirgwin et al., 1979 Biochemistry 18:5294-5299) and cDNA can be prepared using reverse transcriptase (e.g., Moloney MLV reverse transcriptase, available from Gibco/BRL, Bethesda, MD; or AMV reverse transcriptase, available from Seikagaku 25 America, Inc., St. Petersburg, FL). Synthetic oligonucleotide primers for polymerase chain reaction amplification can be designed based upon one of the nucleotide sequences shown in Fig. 1a, lb or 1c. A nucleic acid molecule of the invention can be amplified using cDNA or, alternatively, genomic DNA, as a template and appropriate oligonucleotide primers according to standard PCR amplification techniques. The 30 nucleic acid molecule so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to a SRP encoding nucleotide sequence can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer. 0190.0.1 In a preferred embodiment, an isolated nucleic acid molecule of the 35 invention comprises one of the nucleotide sequences shown in sequences Fig. la, lb or 1 c encoding the SRP (i.e., the "coding region"), as well as 5' untranslated sequences and 3' untranslated sequences.

0191.0.1 Moreover, the nucleic acid molecule of the invention can comprise only a portion of the coding region of one of the sequences 6f the nucleic acid of Fig. 1 a, 1b or 1c, for example, a fragment which can be used as a probe or primer or a fragment encoding a biologically active portion of a SRP. 5 0192.0.1 Portions of proteins encoded by the SRP encoding nucleic acid molecules of the invention are preferably biologically active portions described herein. As used herein, the term "biologically active portion of" a SRP is intended to include a portion, e.g., a domain/motif, of stress related protein that participates in a stress tolerance and/or resistance response in a plant. To determine whether a SRP, or a 10 biologically active portion thereof, results in increased stress tolerance in a plant, a stress analysis of a plant comprising the SRP may be performed. Such analysis methods are well known to those skilled in the art, as detailed in the Examples. More specifically, nucleic acid fragments encoding biologically active portions of a SRP can be prepared by isolating a portion of one of the sequences of the nucleic acid of Fig. 15 la, lb or 1c expressing the encoded portion of the SRP or peptide (e.g., by recombinant expression in vitro) and assessing the activity of the encoded portion of the SRP or peptide. 0193.0.1 Biologically active portions of a SRP are encompassed by the present invention and include peptides comprising amino acid sequences derived from the 20 amino acid sequence of a SRP encoding gene, or the amino acid sequence of a protein homologous to a SRP, which include fewer amino acids than a full length SRP or the full length protein which is homologous to a SRP, and exhibits at least some enzymatic activity of a SRP. Typically, biologically active portions (e.g., peptides which are, for example, 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids 25 in length) comprise a domain or motif with at least one activity of a SRP. Moreover, other biologically active portions in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the activities described herein. Preferably, the biologically active portions of a SRP include one or more selected domains/motifs or portions thereof having biological activity. 30 0194.0.1 The term "biological active portion" or "biological activity" means a SRP or a portion of a SRP which still has at least 10 % or 20 %, preferably 20 %, 30 %, 40 % or 50 %, especially preferably 60 %, 70 % or 80 % of the enzymatic activity of the natural or starting enzyme. 0195.0.2 A nucleic acid molecule encompassing a complete sequence of the 35 nucleic acid molecules used in the process, for example the polynucleotide of the invention, or a part thereof may additionally be isolated by polymerase chain reaction, oligonucleotide primers based on this sequence or on parts thereof being used. For example, a nucleic acid molecule comprising the complete sequence or part thereof can be isolated by polymerase chain reaction using oligonucleotide primers which have been generated on the basis of this sequence-For example, mRNA can be isolated from cells (for example by means of the guanidinium thiocyanate extraction method of 5 Chirgwin et al. (1979) Biochemistry 18:5294-5299) and cDNA can be generated by means of reverse transcriptase (for example Moloney MLV reverse transcriptase, available from Gibco/BRL, Bethesda, MD, or AMV reverse transcriptase, obtainable from Seikagaku America, Inc., St.Petersburg, FL). 0196.0.2 Synthetic oligonucleotide primers for the amplification, e.g. as shown in 10 table 2, by means of polymerase chain reaction can be generated on the basis of a sequence shown herein, for example the sequence shown in Fig. 1a, lb or 1c or the sequences derived from polypeptides as shown in Fig. 1a, lb or 1c. 0197.0.2 Moreover, it is possible to identify conserved regions from various organisms by carrying out protein sequence alignments with the polypeptide used in 15 the process of the invention, in particular with sequences of the polypeptide of the invention, from which conserved regions, and in turn, degenerate primers can be derived. Conserved region for the polypeptide of the invention are indicated in the alignment shown in the figure Fig. la, lb or 1c. Conserved regions are those, which show a very little variation in the amino acid in one particular position of several 20 homologs from different origin. The consenus sequences shown in Fig. 2 are derived from said aligments. 0198.0.2 Degenerated primers can then be utilized by PCR for the amplification of fragments of novel proteins having above-mentioned activity, e.g. having an SPR activity or further functional homologs of the polypeptide of the invention from other 25 organisms. 0199.0.2 These fragments can then be utilized as hybridization probe for isolating the complete gene sequence. As an alternative, the missing 5' and 3' sequences can be isolated by means of RACE-PCR (rapid amplification of cDNA ends). A nucleic acid molecule according to the invention can be amplified using cDNA or, as an alternative, 30 genomic DNA as template and suitable oligonucleotide primers, following standard PCR amplification techniques. The nucleic acid molecule amplified thus can be cloned into a suitable vector and characterized by means of DNA sequence analysis. Oligonucleotides, which correspond to one of the nucleic acid molecules used in the process can be generated by standard synthesis methods, for example using an 35 automatic DNA synthesizer. 0200.0.2 Nucleic acid molecules which are advantageously for the process according to the invention can be isolated based on their homology to the nucleic acid molecules disclosed herein using the sequences or part thereof as hybridization probe and following standard hybridization techniques under stringent hybridization conditions. In this context, it is possible to use, for example, isolated nucleic acid molecules of at least 15, 20, 25, 30, 35, 40, 50, 60 or more nucleotides, preferably of at 5 least 15, 20 or 25 nucleotides in length which hybridize under stringent conditions with the above-described nucleic acid molecules, in particular with those which encompass a nucleotide sequence ofthe nucleic acid molecule used in the process of the invention or encoding a protein used in the invention or of the nucleic acid molecule of the invention. Nucleic acid molecules with 30, 50, 100, 250 or more nucleotides may also 10 be used. 0201.0.1 In addition to fragments of the SRP described herein, the present invention includes homologs and analogs of naturally occurring SRP and SRP encoding nucleic acids in a plant. 0202.0.1 "Homologs" are defined herein as two nucleic acids or proteins that have 15 similar, or "homologous", nucleotide or amino acid sequences, respectively. Homologs include allelic variants, orthologs, paralogs, agonists and antagonists of SRP as defined hereafter. The term "homolog" further encompasses nucleic acid molecules that differ from one of the nucleotide sequences shown in sequences with SEQ ID No. XXX (and portions thereof) due to degeneracy of the genetic code and thus encode the 20 same SRP as that encoded by the amino acid sequences shown in sequences with SEQ ID No. XXX. As used herein a "naturally occurring" SRP refers to a SRP amino acid sequence that occurs in nature. 0203.0.2 The term "homology" means that the respective nucleic acid molecules or encoded proteins are functionally and/or structurally equivalent. The nucleic acid 25 molecules that are homologous to the nucleic acid molecules described above and that are derivatives of said nucleic acid molecules are, for example, variations of said nucleic acid molecules which represent modifications having the same biological function, in particular encoding proteins with the same or substantially the same biological function. They may be naturally occurring variations, such as sequences 30 from other plant varieties or species, or mutations. These mutations may occur naturally or may be obtained by mutagenesis techniques. The allelic variations may be naturally occurring allelic variants as well as synthetically produced or genetically engineered variants. Structurally equivalents can, for example, be identified by testing the binding of said polypeptide to antibodies or computer based predictions. 35 Structurally equivalent have the similar immunological characteristic, e.g. comprise similar epitopes.

0204.0.2 Functional equivalents derived from one of the polypeptides as shown in SEQ ID NO: YYY according to the invention by substitution, insertion or deletion have at least 30%, 35%, 40%, 45% or 50%, preferably at least 55%, 60%, 65% or 70% by preference at least 80%, especially preferably at least 85% or 90%, 91%, 92%, 93% or 5 94%, very especially preferably at least 95%, 97%, 98% or 99% homology with one of the polypeptides as shown in Fig. la, lb or 1c according to the invention and are distinguished by essentially the same properties as the polypeptide as shown in Fig. la, 1b or 1c. 0205.0.2 Functional equivalents derived from the nucleic acid sequence as shown 10 in SEQ ID NO: YYY according to the invention by substitution, insertion or deletion have at least 30%, 35%, 40%, 45% or 50%, preferably at least 55%, 60%, 65% or 70% by preference at least 80%, especially preferably at least 85% or 90%, 91%, 92%, 93% or 94%, very especially preferably at least 95%, 97%, 98% or 99% homology with one of the polypeptides as shown in Fig. 1 a, 1b or 1 c according to the invention and encode 15 polypeptides having essentially the same properties as the polypeptide as shown in Fig. la, 1bor 1c. 0206.0.2 "Essentially the same properties" of a functional equivalent is above all understood as meaning that the functional equivalent has above mentioned acitivty, e.g conferring an increase in the fine chemical amount while increasing the amount of 20 protein, activity or function of said functional equivalent in an organism, e.g. a microorgansim, a plant or plant or animal tissue, plant or animal cells or a part of the same. 0207.0.2 By "hybridizing" it is meant that such nucleic acid molecules hybridize under conventional hybridization conditions, preferably under stringent conditions such 25 as described by, e.g., Sambrook (Molecular Cloning; A Laboratory Manual, 2nd Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989)) or in Current Protocols in Molecular Biology, John Wiley & Sons, N. Y. (1989), 6.3.1-6.3.6. 0208.0.2 According to the invention, DNA as well as RNA molecules of the nucleic acid of the invention can be used as probes. Further, as template for the 30 identification of functional homologues Northern blot assays as well as Southern blot assays can be performed. The Northern blot assay advantageously provides further informations about the expressed gene product: e.g. expression pattern, occurance of processing steps, like splicing and capping, etc. The Southern blot assay provides additional information about the chromosomal localization and organization of the gene 35 encoding the nucleic acid molecule of the invention. 0209.0.2 A preferred, nonlimiting example of stringent hydridization conditions are hybridizations in 6 x sodium chloride/sodium citrate (= SSC) at approximately 45'C, followed by one or more wash steps in 0.2 x SSC, 0.1% SDS at 50 to 65'C, for example at 50'C, 55'C or 60'C. The skilled worker knows that these hybridization conditions differ as a function of the type of the nucleic acid and, for example when organic solvents are present, with regard to the temperature and concentration of the 5 buffer. The temperature under "standard hybridization conditions" differs for example as a function of the type of the nucleic acid between 42'C and 58'C, preferably between 45'C and 50'C in an aqueous buffer with a concentration of 0.1 x 0.5 x, 1 x, 2x, 3x, 4x or 5 x SSC (pH 7.2). If organic solvent(s) is/are present in the abovementioned buffer, for example 50% formamide, the temperature under standard 10 conditions is approximately 40'C, 42'C or 45'C. The hybridization conditions for DNA:DNA hybrids are preferably for example 0.1 x SSC and 20'C, 25'C, 30'C, 35'C, 40'C or 45'C, preferably between 30'C and 45'C. The hybridization conditions for DNA:RNA hybrids are preferably for example 0.1 x SSC and 30'C, 35'C, 40'C, 45'C, 50'C or 55'C, preferably between 45'C and 55'C. The abovementioned hybridization 15 temperatures are determined for example for a nucleic acid approximately 100 bp (= base pairs) in length and a G + C content of 50% in the absence of formamide. The skilled worker knows to determine the hybridization conditions required with the aid of textbooks, for example the ones mentioned above, or from the following textbooks: Sambrook et al., "Molecular Cloning", Cold Spring Harbor Laboratory, 1989; Hames 20 and Higgins (Ed.) 1985, "Nucleic Acids Hybridization: A Practical Approach", IRL Press at Oxford University Press, Oxford; Brown (Ed.) 1991, "Essential Molecular Biology: A Practical Approach", IRL Press at Oxford University Press, Oxford. 0210.0.2 A further example of one such stringent hybridization condition is hybridization at 4XSSC at 65'C, followed by a washing in 0.1XSSC at 65'C for one 25 hour. Alternatively, an exemplary stringent hybridization condition is in 50 % formamide, 4XSSC at 42'C. Further, the conditions during the wash step can be selected from the range of conditions delimited by low-stringency conditions (approximately 2X SSC at 50'C) and high-stringency conditions (approximately 0.2X SSC at 50'C, preferably at 65'C) (20X SSC: 0.3M sodium citrate, 3M NaCl, pH 7.0). In 30 addition, the temperature during the wash step can be raised from low-stringency conditions at room temperature, approximately 22'C, to higher-stringency conditions at approximately 65'C. Both of the parameters salt concentration and temperature can be varied simultaneously, or else one of the two parameters can be kept constant while only the other is varied. Denaturants, for example formamide or SDS, may also be 35 employed during the hybridization. In the presence of 50% formamide, hybridization is preferably effected at 42'C. Relevant factors like i) length of treatment, ii) salt conditions, iii) detergent conditions, iv) competitor DNAs, v) temperature and vi) probe selection can be combined case by case so that not all possibilities can be mentioned herein. 0211.0.2 Thus, in a preferred embodiment, Northern blots are prehybridized with Rothi-Hybri-Quick buffer (Roth, Karlsruhe) at 68'C for 2h. Hybridzation with radioactive 5 labelled probe is done overnight at 68'C. Subsequent washing steps are performed at 68'C with 1xSSC. 0212.0.2 For Southern blot assays the membrane is prehybridized with Rothi Hybri-Quick buffer (Roth, Karlsruhe) at 68'C for 2h. The hybridzation with radioactive labelled probe is conducted over night at 68'C. Subsequently the hybridization buffer is 10 discarded and the filter shortly washed using 2xSSC; 0,1% SDS. After discarding the washing buffer new 2xSSC; 0,1% SDS buffer is added and incubated at 68'C for 15 minutes. This washing step is performed twice followed by an additional washing step using 1xSSC; 0,1% SDS at 68'C for 10 min. 0213.0.2 Some further examples of conditions for DNA hybridization (Southern 15 blot assays) and wash step are shown hereinbelow: (1) Hybridization conditions can be selected, for example, from the following conditions: a) 4X SSC at 65'C, b) 6X SSC at 45'C, 20 c) 6X SSC, 100 mg/ml denatured fragmented fish sperm DNA at 68'C, d) 6X SSC, 0.5% SDS, 100 mg/ml denatured salmon sperm DNA at 680C, e) 6X SSC, 0.5% SDS, 100 mg/ml denatured fragmented salmon sperm DNA, 50% formamide at 420C, 25 f) 50% formamide, 4X SSC at 420C, g) 50% (vol/vol) formamide, 0.1% bovine serum albumin, 0.1% Ficoll, 0.1% polyvinylpyrrolidone, 50 mM sodium phosphate buffer pH 6.5, 750 mM NaCl, 75 mM sodium citrate at 420C, h) 2X or 4X SSC at 500C (low-stringency condition), or 30 i) 30 to 40% formamide, 2X or 4X SSC at 420C (low-stringency condition). (2) Wash steps can be selected, for example, from the following conditions: a) 0.015 M NaCI/0.0015 M sodium citrate/0.1% SDS at 500C. b) 0.1X SSC at 650C. 35 c) 0.1X SSC, 0.5 % SDS at 68 0 C. d) 0.1X SSC, 0.5% SDS, 50% formamide at 420C. e) 0.2X SSC, 0.1% SDS at 420C.

f) 2X SSC at 650C (low-stringency condition). 0214.0.1 In an other embodiment is meant by standard conditions, for example, depending on the nucleic acid in question temperatures between 420C and 580C in an aqueous buffer solution having a concentration of between 0.1 and 5 x SSC (1 X SSC 5 = 0.15 M NaCl, 15 mM sodium citrate, pH 7.2) or additionally in the presence of 50 % formamide, such as by way of example 420C in 5 x SSC, 50 % formamide. Hybridization conditions for DNA:DNA hybrids are advantageously 0.1 x SSC and temperatures between approximately 200C and 450C, preferably between approximately 30 oC and 45 oC. For DNA:RNA hybrids the hybridization conditions are 10 advantageously 0.1 x SSC and temperatures between approximately 300C and 550C, preferably between approximately 450C and 550C. These specified temperatures for hybridization are melting temperature values calculated by way of example for a nucleic acid having a length of approximately 100 nucleotides and a G + C content of 50 % in the absence of formamide. The experimental conditions for DNA hybridization 15 are described in relevant genetics textbooks such as by way of example Sambrook et al., Molecular Cloning", Cold Spring Harbor Laboratory, 1989, and may be calculated by formulae known to those skilled in the art, for example as a function of the length of the nucleic acids, the nature of the hybrids or the G + C content. Those skilled in the art may draw on the following textbooks for further information on hybridization: Ausubel et 20 al. (eds), 1985, Current Protocols in Molecular Biology, John Wiley & Sons, New York; Hames and Higgins (eds), 1985, Nucleic Acids Hybridization: A Practical Approach, IRL Press at Oxford University Press, Oxford; Brown (ed), 1991, Essential Molecular Biology: A Practical Approach, IRL Press at Oxford University Press, Oxford. 0215.0.2 Polypeptides having above-mentioned activity, i.e. conferring the altered 25 metabolic activity, derived from other organisms, can be encoded by other DNA sequences which hybridize to the sequences shown in Fig. 1a, 1b or 1c under relaxed hybridization conditions and which code on expression for peptides confering an altered metabolic activity. 0216.0.2 Further, some applications have to be performed at low stringency 30 hybridisation conditions, without any consequences for the specificity of the hybridisation. For example, a Southern blot analysis of total DNA could be probed with a nucleic acid molecule of the present invention and washed at low stringency (55 0 C in 2xSSPE0,1% SDS). The hybridisation analysis could reveal a simple pattern of only genes encoding polypeptides of the present invention or used in the process of the 35 invention, e.g. having herein-mentioned activity of increasing the fine chemical . A further example of such low-stringent hybridization conditions is 4XSSC at 50 0 C or hybridization with 30 to 40% formamide at 42 0 C. Such molecules comprise those which are fragments, analogues or derivatives of the polypeptide of the invention or used in the process of the invention and differ, for example, by way of amino acid and/or nucleotide deletion(s), insertion(s), substitution (s), addition(s) and/or recombination (s) or any other modification(s) known in the art either alone or in combination from the 5 above-described amino acid sequences or their underlying nucleotide sequence(s). However, it is preferred to use high stringency hybridisation conditions. 0217.0.2 Hybridization should advantageously be carried out with fragments of at least 5, 10, 15, 20, 25, 30, 35 or 40 bp, advantageously at least 50, 60, 70 or 80 bp, preferably at least 90, 100 or 110 bp. Most preferably are fragments of at least 15, 20, 10 25 or 30 bp. Preferably are also hybridizations with at least 100 bp or 200, very especially preferably at least 400 bp in length. In an especially preferred embodiment, the hybridization should be carried out with the entire nucleic acid sequence with conditions described above. 0218.0.2 The terms "fragment", "fragment of a sequence" or "part of a sequence" 15 mean a truncated sequence of the original sequence referred to. The truncated sequence (nucleic acid or protein sequence) can vary widely in length; the minimum size being a sequence of sufficient size to provide a sequence with at least a comparable function and/or activity of the original sequence referred to or hybidizing with the nucleic acid molecule of the invention or used in the process of the invention 20 under stringend conditions, while the maximum size is not critical. In some applications, the maximum size usually is not substantially greater than that required to provide the desired activity and/or function(s) of the original sequence. 0219.0.3 In addition to fragments and fusion polypeptides of the SRPs described herein, the present invention includes homologs and analogs of naturally occurring 25 SRPs and SRP encoding nucleic acids in a plant. "Homologs" are defined herein as two nucleic acids or polypeptides that have similar, or substantially identical, nucleotide or amino acid sequences, respectively. Homologs include allelic variants, orthologs, paralogs, agonists and antagonists of SRPs as defined hereafter. The term "homolog" further encompasses nucleic acid molecules that differ from one of the nucleotide 30 sequences shown in Fig. la, lb or 1c (and portions thereof) due to degeneracy of the genetic code and thus encode the same SRP as that encoded by the nucleotide sequences shown in Fig. la, lb or 1c. As used herein a "naturally occurring" SRP refers to a SRP amino acid sequence that occurs in nature. Preferably, a naturally occurring SRP comprises an amino acid sequence selected from the group consisting 35 of polypeptides of Fig. 1a, 1b or 1c. 0220.0.3 An agonist of the SRP can retain substantially the same, or a subset, of the biological activities of the SRP. An antagonist of the SRP can inhibit one or more of the activities of the naturally occurring form of the SRP. For example, the SRP antagonist can competitively bind to a downstream or upstream member of the cell membrane component metabolic cascade that includes the SRP, or bind to a SRP that mediates transport of compounds across such membranes, thereby preventing 5 translocation from taking place. 0221.0.3 Nucleic acid molecules corresponding to natural allelic variants and analogs, orthologs and paralogs of a SRP cDNA can be isolated based on their identity to the Saccharomyces cerevisiae, E.coli, Brassica napus, Glycine max, or Oryza sativa 10 SRP nucleic acids described herein using SRP cDNAs, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions. In an alternative embodiment, homologs of the SRP can be identified by screening combinatorial libraries of mutants, e.g., truncation mutants, of the SRP for SRP agonist or antagonist activity. In one embodiment, a variegated library 15 of SRP variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of SRP variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential SRP sequences is expressible as individual polypeptides, or alternatively, as a set of larger 20 fusion polypeptides (e.g., for phage display) containing the set of SRP sequences therein. There are a variety of methods that can be used to produce libraries of potential SRP homologs from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene is then ligated into an appropriate expression 25 vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential SRP sequences. Methods for synthesizing degenerate oligonucleotides are known in the art. See, e.g., Narang, S.A., 1983, Tetrahedron 39:3; Itakura et al., 1984, Annu. Rev. Biochem. 53:323; Itakura et al., 1984, Science 198:1056; Ike et al., 1983, Nucleic Acid Res. 11:477. 30 0222.0.3 In addition, libraries of fragments of the SRP coding regions can be used to generate a variegated population of SRP fragments for screening and subsequent selection of homologs of a SRP. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of a SRP coding sequence with a nuclease under conditions wherein nicking occurs only 35 about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA, which can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with S1 nuclease, and ligating the resulting fragment library into an expression vector. By this method, an expression library can be derived which encodes N-terminal, C-terminal, and internal fragments of various sizes of the SRP. 0223.0.3 Several techniques are known in the art for screening gene products of 5 combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of SRP homologs. The most widely used techniques, which are amenable to high through-put analysis, for screening large gene libraries typically include cloning the 10 gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recursive ensemble mutagenesis (REM), a new technique that enhances the frequency of functional mutants in the libraries, can be 15 used in combination with the screening assays to identify SRP homologs (Arkin and Yourvan, 1992, PNAS 89:7811-7815; Delgrave et al., 1993, Polypeptide Engineering 6(3):327-331). In another embodiment, cell based assays can be exploited to analyze a variegated SRP library, using methods well known in the art. The present invention further provides a method of identifying a novel SRP, comprising (a) raising a specific 20 antibody response to a SRP, or a fragment thereof, as described herein; (b) screening putative SRP material with the antibody, wherein specific binding of the antibody to the material indicates the presence of a potentially novel SRP; and (c) analyzing the bound material in comparison to known SRP, to determine its novelty. 0224.0.3 As stated above, the present invention includes SRPs and homologs 25 thereof. To determine the percent sequence identity of two amino acid sequences (e.g., one of the sequences of Fig. la, lb or 1c, and a mutant form thereof), the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in the sequence of one polypeptide for optimal alignment with the other polypeptide or nucleic acid). The amino acid residues at corresponding amino acid positions are then 30 compared. When a position in one sequence (e.g., one of the sequences of Fig. 1a, 1b or 1c) is occupied by the same amino acid residue as the corresponding position in the other sequence (e.g., a mutant form of the sequence selected from the polypeptide of Fig. 1a, lb or 1c), then the molecules are identical at that position. The same type of comparison can be made between two nucleic acid sequences. 35 0225.0.3 The percent sequence identity between the two sequences is a function of the number of identical positions shared by the sequences (i.e., percent sequence identity = numbers of identical positions/total numbers of positions x 100). Preferably, the isolated amino acid homologs included in the present invention are at least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-75%, 75-80%, 80-85%, 85-90% or 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more identical to an entire amino acid sequence shown in Fig. 1a, 1b or 5 1c. In yet another embodiment, the isolated amino acid homologs included in the present invention are at least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-75%, 75-80%, 80-85%, 85-90% or 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more identical to an entire amino acid sequence encoded by a nucleic acid sequence shown in Fig. 1a, lb or 1c. In other 10 embodiments, the SRP amino acid homologs have sequence identity over at least 15 contiguous amino acid residues, more preferably at least 25 contiguous amino acid residues, and most preferably at least 35 contiguous amino acid residues of Fig. 1a, 1b or 1c. 0226.0.3 In another preferred embodiment, an isolated nucleic acid homolog of 15 the invention comprises a nucleotide sequence which is at least about 50-60%, preferably at least about 60-70%, more preferably at least about 70-75%, 75-80%, 80 85%, 85-90% or 90-95%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more identical to a nucleotide sequence shown Fig. 1a, lb or 1c, or to a portion comprising at least 20, 30, 40, 50, 60 consecutive nucleotides thereof. The 20 preferable length of sequence comparison for nucleic acids is at least 75 nucleotides, more preferably at least 100 nucleotides and most preferably the entire length of the coding region. 0227.0.3 It is further preferred that the isolated nucleic acid homolog of the invention encodes a SRP, or portion thereof, that is at least 85% identical to an amino 25 acid sequence of Fig. la, lb or 1c and that functions as a modulator of an environmental stress response in a plant. In a more preferred embodiment, overexpression of the nucleic acid homolog in a plant increases the tolerance of the plant to an environmental stress. 0228.0.3 For the purposes of the invention, the percent sequence identity 30 between two nucleic acid or polypeptide sequences is determined using the Vector NTI 6.0 (PC) software package (InforMax, 7600 Wisconsin Ave., Bethesda, MD 20814). A gap opening penalty of 15 and a gap extension penalty of 6.66 are used for determining the percent identity of two nucleic acids. A gap opening penalty of 10 and a gap extension penalty of 0.1 are used for determining the percent identity of two 35 polypeptides. All other parameters are set at the default settings. For purposes of a multiple alignment (Clustal W algorithm), the gap opening penalty is 10, and the gap extension penalty is 0.05 with blosum62 matrix. It is to be understood that for the purposes of determining sequence identity when comparing a DNA sequence to an RNA sequence, a thymidine nucleotide is equivalent to a uracil nucleotide. 0228.1.3 In another aspect, the invention provides an isolated nucleic acid comprising a polynucleotide that hybridizes to the polynucleotide of Fig. 1a, lb or 1c 5 under stringent conditions. More particularly, an isolated nucleic acid molecule of the invention is at least 15 nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising a nucleotide sequence of Fig. 1a, lb or 1c. In other embodiments, the nucleic acid is at least 30, 50, 100, 250 or more nucleotides in length. Preferably, an isolated nucleic acid homolog of the invention comprises a 10 nucleotide sequence which hybridizes under highly stringent conditions to the nucleotide sequence shown in Fig. 1a, 1b or 1c, and functions as a modulator of stress tolerance in a plant. In a further preferred embodiment, overexpression of the isolated nucleic acid homolog in a plant increases a plant's tolerance to an environmental stress. 15 0229.0.3 As used herein with regard to hybridization for DNA to DNA blot, the term "stringent conditions" refers in one embodiment to hybridization overnight at 600C in 1oX Denharts solution, 6X SSC, 0.5% SDS and 100 Vtg/ml denatured salmon sperm DNA. Blots are washed sequentially at 620C for 30 minutes each time in 3X SSC/0.1% SDS, followed by 1X SSC/0.1% SDS and finally 0.1X SSC/0.1% SDS. As also used 20 herein, "highly stringent conditions" refers to hybridization overnight at 650C in 1OX Denharts solution, 6X SSC, 0.5% SDS and 100 Vtg/ml denatured salmon sperm DNA. Blots are washed sequentially at 650C for 30 minutes each time in 3X SSC/O.1% SDS, followed by 1X SSC/0.1% SDS and finally 0.1X SSC/0.1% SDS. Methods for nucleic acid hybridizations are described in Meinkoth and Wahl, 1984, Anal. Biochem. 25 138:267-284; Ausubel et al. eds, 1995, Current Protocols in Molecular Biology, Chapter 2, Greene Publishing and Wiley-Interscience, New York; and Tijssen, 1993, Laboratory Techniques in Biochemistry and Molecular Biology: Hybridization with Nucleic Acid Probes, Part I, Chapter 2, Elsevier, New York. Preferably, an isolated nucleic acid molecule of the invention that hybridizes under stringent or highly stringent conditions 30 to a sequence of Fig. la, lb or 1c corresponds to a naturally occurring nucleic acid molecule. As used herein, a "naturally occurring" nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural polypeptide). In one embodiment, the nucleic acid encodes a naturally occurring Saccharomyces cerevisiae, E.coli, Brassica napus, Glycine max, or 35 Oryza sativa SRP. 0230.0.3 Using the above-described methods, and others known to those of skill in the art, one of ordinary skill in the art can isolate homologs of the SRPs comprising amino acid sequences shown in Fig. 1a, lb or 1c. One subset of these homologs are allelic variants. As used herein, the term "allelic variant" refers to a nucleotide sequence containing polymorphisms that lead to changes in the amino acid sequences of a SRP and that exist within a natural population (e.g., a plant species or variety). 5 Such natural allelic variations can typically result in 1-5% variance in a SRP nucleic acid. Allelic variants can be identified by sequencing the nucleic acid sequence of interest in a number of different plants, which can be readily carried out by using hybridization probes to identify the same SRP genetic locus in those plants. Any and all such nucleic acid variations and resulting amino acid polymorphisms or variations in 10 a SRP that are the result of natural allelic variation and that do not alter the functional activity of a SRP, are intended to be within the scope of the invention. 0231.0.3 An isolated nucleic acid molecule encoding a SRP having sequence identity with a polypeptide sequence of Fig. 1a, 1b or 1c can be created by introducing one or more nucleotide substitutions, additions or deletions into a nucleotide sequence 15 of Fig. la, lb or 1c, respectively, such that one or more amino acid substitutions, additions, or deletions are introduced into the encoded polypeptide. Mutations can be introduced into one of the sequences of Fig. 1a, 1b or 1c by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted non-essential 20 amino acid residues. A "conservative amino acid substitution" is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. 0232.0.3 Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), 25 uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in a SRP is 30 preferably replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of a SRP coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for a SRP activity described herein to identify mutants that retain SRP activity. Following mutagenesis of one of the sequences of 35 SEQ ID NO:XXX, the encoded polypeptide can be expressed recombinantly and the activity of the polypeptide can be determined by analyzing the stress tolerance of a plant expressing the polypeptide as described herein.

0233.0.3 Additionally, optimized SRP nucleic acids can be created. As used herein, "optimized" refers to a nucleic acid that is genetically engineered to increase its expression in a given plant or animal. To provide plant optimized SRP nucleic acids, the DNA sequence of the gene can be modified to 1) comprise codons preferred by 5 highly expressed plant genes; 2) comprise an A+T content in nucleotide base composition to that substantially found in plants; 3) form a plant initiation sequence; or 4) eliminate sequences that cause destabilization, inappropriate polyadenylation, degradation, and termination of RNA, or that form secondary structure hairpins or RNA splice sites. Increased expression of SRP nucleic acids in plants can be achieved by 10 utilizing the distribution frequency of codon usage in plants in general or a particular plant. Methods for optimizing nucleic acid expression in plants can be found in EPA 0359472; EPA 0385962; PCT Application No. WO 91/16432; U.S. Patent No. 5,380,831; U.S. Patent No. 5,436,391; Perlack et al., 1991, Proc. NatI. Acad. Sci. USA 88:3324-3328; and Murray et al., 1989, Nucleic Acids Res. 17:477-498. 15 0234.0.3 As used herein, "frequency of preferred codon usage" refers to the preference exhibited by a specific host cell in usage of nucleotide codons to specify a given amino acid. To determine the frequency of usage of a particular codon in a gene, the number of occurrences of that codon in the gene is divided by the total number of occurrences of all codons specifying the same amino acid in the gene. 20 Similarly, the frequency of preferred codon usage exhibited by a host cell can be calculated by averaging frequency of preferred codon usage in a large number of genes expressed by the host cell. It is preferable that this analysis be limited to genes that are highly expressed by the host cell. The percent deviation of the frequency of preferred codon usage for a synthetic gene from that employed by a host cell is 25 calculated first by determining the percent deviation of the frequency of usage of a single codon from that of the host cell followed by obtaining the average deviation over all codons. As defined herein, this calculation includes unique codons (i.e., ATG and TGG). In general terms, the overall average deviation of the codon usage of an optimized gene from that of a host cell is calculated using the equation 1A = n = 1 Z X, 30 - Y, X, times 100 Z where X, = frequency of usage for codon n in the host cell; Y, = frequency of usage for codon n in the synthetic gene; n represents an individual codon that specifies an amino acid; and the total number of codons is Z. The overall deviation of the frequency of codon usage, A, for all amino acids should preferably be less than about 25%, and more preferably less than about 10%. 35 0235.0.3 Hence, a SRP nucleic acid can be optimized such that its distribution frequency of codon usage deviates, preferably, no more than 25% from that of highly expressed plant genes and, more preferably, no more than about 10%. In addition, consideration is given to the percentage G+C content of the degenerate third base (monocotyledons appear to favor G+C in this position, whereas dicotyledons do not). It is also recognized that the XCG (where X is A, T, C, or G) nucleotide is the least preferred codon in dicots whereas the XTA codon is avoided in both monocots and 5 dicots. Optimized SRP nucleic acids of this invention also preferably have CG and TA doublet avoidance indices closely approximating those of the chosen host plant (i.e., Brassica napus, Glycine max, or Oryza sativa). More preferably these indices deviate from that of the host by no more than about 10-15%. 0236.0.3 In addition to the nucleic acid molecules encoding the SRPs described 10 above, another aspect of the invention pertains to isolated nucleic acid molecules that are antisense thereto. Antisense polynucleotides are thought to inhibit gene expression of a target polynucleotide by specifically binding the target polynucleotide and interfering with transcription, splicing, transport, translation, and/or stability of the target polynucleotide. Methods are described in the prior art for targeting the antisense 15 polynucleotide to the chromosomal DNA, to a primary RNA transcript, or to a processed mRNA. Preferably, the target regions include splice sites, translation initiation codons, translation termination codons, and other sequences within the open reading frame. 0237.0.3 The term "antisense," for the purposes of the invention, refers to a 20 nucleic acid comprising a polynucleotide that is sufficiently complementary to all or a portion of a gene, primary transcript, or processed mRNA, so as to interfere with expression of the endogenous gene. "Complementary" polynucleotides are those that are capable of base pairing according to the standard Watson-Crick complementarity rules. bpecifically, purines will base pair with pyrimidines to form a combination of 25 guanine paired with cytosine (G:C) and adenine paired with either thymine (A:T) in the case of DNA, or adenine paired with uracil (A:U) in the case of RNA. It is understood that two polynucleotides may hybridize to each other even if they are not completely complementary to each other, provided that each has at least one region that is substantially complementary to the other. The term "antisense nucleic acid" includes 30 single stranded RNA as well as double-stranded DNA expression cassettes that can be transcribed to produce an antisense RNA. "Active" antisense nucleic acids are antisense RNA molecules that are capable of selectively hybridizing with a primary transcript or mRNA encoding a polypeptide having at least 80% sequence identity with the polypeptide of Fig. 1a, 1b or 1c. 35 0238.0.3 The antisense nucleic acid can be complementary to an entire SRP coding strand, or to only a portion thereof. In one embodiment, an antisense nucleic acid molecule is antisense to a "coding region" of the coding strand of a nucleotide sequence encoding a SRP. The term "coding region" refers to the region of the nucleotide sequence comprising codons that are translated into amino acid residues. In another embodiment, the antisense nucleic acid molecule is antisense to a "noncoding region" of the coding strand of a nucleotide sequence encoding a SRP. The term 5 "noncoding region" refers to 5' and 3' sequences that flank the coding region that are not translated into amino acids (i.e., also referred to as 5' and 3' untranslated regions). The antisense nucleic acid molecule can be complementary to the entire coding region of SRP mRNA, but more preferably is an oligonucleotide which is antisense to only a portion of the coding or noncoding region of SRP mRNA. For example, the antisense 10 oligonucleotide can be complementary to the region surrounding the translation start site of PKSRP mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. Typically, the antisense molecules of the present invention comprise an RNA having 60-100% sequence identity with at least 14 consecutive nucleotides of one of the nucleic acid of Fig. 1a, 1b 15 or 1c. Preferably, the sequence identity will be at least 70%, more preferably at least 75%, 80%, 85%, 90%, 95%, 98% and most preferably 99%. 0239.0.3 An antisense nucleic acid of the invention can be constructed using chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be 20 chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Examples of modified nucleotides which can be used to generate the antisense 25 nucleic acid include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5 carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1 methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2 30 methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5 methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D mannosylqueosine, 5'-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N6 isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5 35 oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3 amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection). 0240.0.3 In yet another embodiment, the antisense nucleic acid molecule of the 5 invention is an a-anomeric nucleic acid molecule. An a-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual p-units, the strands run parallel to each other (Gaultier et al., 1987, Nucleic Acids. Res. 15:6625-6641). The antisense nucleic acid molecule can also comprise a 2'-o-methylribonucleotide (Inoue et al., 1987, Nucleic Acids Res. 15:6131-6148) or a 10 chimeric RNA-DNA analogue (Inoue et al., 1987, FEBS Lett. 215:327-330). 0241.0.3 The antisense nucleic acid molecules of the invention are typically administered to a cell or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a SRP to thereby inhibit expression of the polypeptide, e.g., by inhibiting transcription and/or translation. The hybridization 15 can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule which binds to DNA duplexes, through specific interactions in the major groove of the double helix. The antisense molecule can be modified such that it specifically binds to a receptor or an antigen expressed on a selected cell surface, e.g., by linking the antisense nucleic acid 20 molecule to a peptide or an antibody which binds to a cell surface receptor or antigen. The antisense nucleic acid molecule can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of the antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong prokaryotic, viral, or eukaryotic (including plant) promoter 25 are preferred. 0242.0.3 As an alternative to antisense polynucleotides, ribozymes, sense polynucleotides, or double stranded RNA (dsRNA) can be used to reduce expression of a SRP polypeptide. By "ribozyme" is meant a catalytic RNA-based enzyme with ribonuclease activity which is capable of cleaving a single-stranded nucleic acid, such 30 as an mRNA, to which it has a complementary region. Ribozymes (e.g., hammerhead ribozymes described in Haselhoff and Gerlach, 1988, Nature 334:585-591) can be used to catalytically cleave SRP mRNA transcripts to thereby inhibit translation of SRP mRNA. A ribozyme having specificity for a SRP-encoding nucleic acid can be designed based upon the nucleotide sequence of a SRP cDNA, as disclosed herein (i.e., Fig. la, 35 lb or 1c) or on the basis of a heterologous sequence to be isolated according to methods taught in this invention. For example, a derivative of a Tetrahymena L-1 9 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a SRP-encoding mRNA. See, e.g., U.S. Patent Nos. 4,987,071 and 5,116,742 to Cech et al. Alternatively, SRP mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel, D. and Szostak, J.W., 1993, Science 5 261:1411-1418. In preferred embodiments, the ribozyme will contain a portion having at least 7, 8, 9, 10, 12, 14, 16, 18 or 20 nucleotides, and more preferably 7 or 8 nucleotides, that have 100% complementarity to a portion of the target RNA. Methods for making ribozymes are known to those skilled in the art. See, e.g., U.S. Patent Nos. 6,025,167; 5,773,260; and 5,496,698. 10 0243.0.3 The term "dsRNA," as used herein, refers to RNA hybrids comprising two strands of RNA. The dsRNAs can be linear or circular in structure. In a preferred embodiment, dsRNA is specific for a polynucleotide encoding either the polypeptide of Fig. la, lb or 1c or a polypeptide having at least 70% sequence identity with a polypeptide of Fig. la, lb or 1c. The hybridizing RNAs may be substantially or 15 completely complementary. By "substantially complementary," is meant that when the two hybridizing RNAs are optimally aligned using the BLAST program as described above, the hybridizing portions are at least 95% complementary. Preferably, the dsRNA will be at least 100 base pairs in length. Typically, the hybridizing RNAs will be of identical length with no over hanging 5' or 3' ends and no gaps. However, dsRNAs 20 having 5' or 3' overhangs of up to 100 nucleotides may be used in the methods of the invention. 0244.0.3 The dsRNA may comprise ribonucleotides or ribonucleotide analogs, such as 2'-O-methyl ribosyl residues, or combinations thereof. See, e.g., U.S. Patent Nos. 4,130,641 and 4,024,222. A dsRNA polyriboinosinic acid:polyribocytidylic acid is 25 described in U.S. patent 4,283,393. Methods for making and using dsRNA are known in the art. One method comprises the simultaneous transcription of two complementary DNA strands, either in vivo, or in a single in vitro reaction mixture. See, e.g., U.S. Patent No. 5,795,715. In one embodiment, dsRNA can be introduced into a plant or plant cell directly by standard transformation procedures. Alternatively, 30 dsRNA can be expressed in a plant cell by transcribing two complementary RNAs. 0245.0.3 Other methods for the inhibition of endogenous gene expression, such as triple helix formation (Moser et al., 1987, Science 238:645-650 and Cooney et al., 1988, Science 241:456-459) and cosuppression (Napoli et al., 1990, The Plant Cell 2:279-289) are known in the art. Partial and full-length cDNAs have been used for the 35 cosuppression of endogenous plant genes. See, e.g., U.S. Patent Nos. 4,801,340, 5,034,323, 5,231,020, and 5,283,184; Van der Kroll et al., 1990, The Plant Cell 2:291- 299; Smith et al., 1990, Mol. Gen. Genetics 224:477-481 and Napoli et al., 1990, The Plant Cell 2:279-289. 0246.0.3 For sense suppression, it is believed that introduction of a sense polynucleotide blocks transcription of the corresponding target gene. The sense 5 polynucleotide will have at least 65% sequence identity with the target plant gene or RNA. Preferably, the percent identity is at least 80%, 90%, 95% or more. The introduced sense polynucleotide need not be full length relative to the target gene or transcript. Preferably, the sense polynucleotide will have at least 65% sequence identity with at least 100 consecutive nucleotides of one of the nucleic acids of Fig. 1a, 10 lb or 1c. The regions of identity can comprise introns and and/or exons and untranslated regions. The introduced sense polynucleotide may be present in the plant cell transiently, or may be stably integrated into a plant chromosome or extrachromosomal replicon. 0247.0.1 Moreover, nucleic acid molecules encoding SRP from the same or other 15 species such as SRP analogs, orthologs and paralogs, are intended to be within the scope of the present invention. As used herein, the term "analogs" refers to two nucleic acids that have the same or similar function, but that have evolved separately in unrelated organisms. As used herein, the term "orthologs" refers to two nucleic acids from different species that have evolved from a common ancestral gene by speciation. 20 Normally, orthologs encode proteins having the same or similar functions. As also used herein, the term "paralogs" refers to two nucleic acids that are related by duplication within a genome. Paralogs usually have different functions, but these functions may be related (Tatusov, R.L. et al. 1997 Science 278(5338):631-637). Analogs, orthologs and paralogs of a naturally occurring stress related protein can differ from the naturally 25 occurring stress related protein by post-translational modifications, by amino acid sequence differences, or by both. Post-translational modifications include in vivo and in vitro chemical derivatization of polypeptides e.g., acetylation, carboxylation, phosphorylation or glycosylation, and such modifications may occur during polypeptide synthesis or processing or following treatment with isolated modifying enzymes. In 30 particular, orthologs of the invention will generally exhibit at least 80-85%, more preferably 90%, 91%, 92%, 93%, 94%, and most preferably 95%, 96%, 97%, 98% or even 99% identity or homology with all or part of a naturally occurring stress related protein amino acid sequence and will exhibit a function similar to a stress related protein. Orthologs of the present invention are also preferably capable of participating 35 in the stress response in plants. 0248.0.1 In addition to naturally-occurring variants of a stress related protein sequence that may exist in the population, the skilled artisan will further appreciate that changes can be introduced by mutation into a nucleotide sequence of the Fig. 1a, 1b or 1c, thereby leading to changes in the amino acid sequence of the encoded stress related protein, without altering the functional ability of the stress related protein or enhancing the functional ability of the stress related protein. For example, nucleotide 5 substitutions leading to amino acid substitutions at "non-essential" amino acid residues can be made in a sequence of Fig 1. A "non-essential" amino acid residue is a residue that can be altered from the wild-type sequence of one of stress related proteins without altering the activity thereof, whereas an "essential" amino acid residue is required for stress related protein activity. Other amino acid residues, however, (e.g., 10 those that are not conserved or only semi-conserved in the domain having SRP activity) may not be essential for activity and thus are likely to be amenable to alteration without altering SRP activity. 0249.0.1 Accordingly, another aspect of the invention pertains to nucleic acid molecules encoding stress related proteins that contain changes in amino acid 15 residues that are not essential for stress related protein activity. Such SRP differ in amino acid sequence from a sequence Fig. 1a, lb or 1c, yet retain at least one of the stress related protein activities described herein. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 50% homologous to an 20 amino acid sequence of Fig. la, lb or 1c. Preferably, the protein encoded by the nucleic acid molecule is at least about 50-60% homologous to one of the sequences of the Fig. 1 a, 1b or 1 c, more preferably at least about 60 - 70% homologous to one of the sequences of the Fig. 1a, lb or 1c, even more preferably at least about 70 - 80%, 80 90%, more preferably 90%, 91%, 92%, 93%, 94% homologous to one of the 25 sequences of the Fig. 1a, lb or 1c and most preferably at least about 96%, 97%, 98%, or 99% homologous to one of the sequences of the Fig. 1a, lb or 1c. The preferred stress related protein homologs of the present invention are preferably capable of participating in the stress tolerance response in a plant. The homology (= identity) was calculated over the entire amino acid range. The program used was PileUp (J. Mol. 30 Evolution., 25 (1987), 351-360, Higgins et al., CABIOS, 5 1989: 151-153). 0250.0.1 Homologs of the sequences given in Fig. 1a, 1b or 1c are furthermore to be understood as meaning, for example, homologs, analogs, orthologs and paralogs which have at least 30% homology (= identity) at the derived amino acid level, preferably at least 50 %, 60 %, 70 % or 80 % homology, especially preferably at least 35 85 % homology, very especially preferably 90 % 91%, 92%, 93%, 94%homology, most preferably 95 %, 96 %, 97 %, 98 % or 99 % homology. The homology (= identity) was calculated over the entire amino acid range. The program used was PileUp (J. Mol.

Evolution., 25 (1987), 351 - 360, Higgens et al., CABIOS, 5 1989: 151 - 153) or the program Gap and BestFit [Needleman and Wunsch (J. Mol. Biol. 48; 443 - 453 (1970) and Smith and Waterman respectively (Adv. Apple. Math. 2; 482 - 489 (1981)] which are part of the GCG software package [Genetics Computer Group, 575 Science Drive, 5 Madison, Wisconsin, USA 53711 (1991)]. The above mentioned percentages of sequence homology are calculated with the program BestFit or Gap, preferably Gap, over the total sequence length with the following parameters used: Gap Weight: 8, Length Weight: 2. 0251.0.1 Variants shall also be encompassed, in particular, functional variants 10 which can be obtained from the sequence shown in the Fig. la, lb or 1c by means of deletion, insertion or substitution of nucleotides, the enzymatic activity of the derived synthetic proteins being retained or enhanced. 0252.0.1 An isolated nucleic acid molecule encoding a stress related protein homologous to a protein sequence of Fig. 1a, lb or 1c can be created by introducing 15 one or more nucleotide substitutions, additions or deletions into a nucleotide sequence of Fig. la, lb or 1c such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein. Mutations can be introduced into one of the sequences of Fig. la, lb or 1c by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Another route to the mutagenesis of 20 enzymes, disclosed in the European Publication EP-A-0 909 821, is a method using the specific Escherichia coli strain XL1-Red to generate mutants and altered the enzyme activity. 0253.0.1 Preferably, conservative amino acid substitutions are made at one or more predicted non-essential amino acid residues. A "conservative amino acid 25 substitution" is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. 0254.0.1 Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), 30 uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in a stress 35 related protein is preferably replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of a stress related protein coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for a stress related protein activity as described herein to identify mutants that retain stress related protein activity or show enhanced stress related protein activity. Following mutagenesis of one of the sequences of the nucleic acid of Fig. 1a, lb or 1c, the encoded protein can be 5 expressed recombinantly and the activity of the protein can be determined by analyzing the stress tolerance of a plant expressing the protein as described in the examples below. 0255.0.1 A useful method to ascertain the level of transcription of the gene (an indicator of the amount of mRNA available for translation to the gene product) is to 10 perform a Northern blot (for reference see, for example, Ausubel et al., 1988 Current Protocols in Molecular Biology, Wiley: New York). This information at least partially demonstrates the degree of transcription of the gene. Total cellular RNA can be prepared from cells, tissues or organs by several methods, all well-known in the art, such as that described in Bormann, E.R. et al., 1992 Mol. Microbiol. 6:317-326. To 15 assess the presence or relative quantity of protein translated from this mRNA, standard techniques, such as a Western blot, may be employed. These techniques are well known to one of ordinary skill in the art (see, for example, Ausubel et al., 1988 Current Protocols in Molecular Biology, Wiley: New York). 0256.0.1 The present invention also relates to a plant expression cassette 20 comprising a SRP coding nucleic acid selected from the group comprising sequences of SEQ IDs No. XXX and/or homologs or parts thereof operatively linked to regulatory sequences and/or targeting sequences. 0257.0.1 Further, object of the invention is an expression vector comprising a SRP encoding nucleic acid selected from the group comprising sequences of the 25 nucleic acid of Fig. 1a, 1b or 1c and/or homologs or parts thereof or a plant expression cassette as described above, whereby expression of the SRP coding nucleic acid in a host cell results in increased tolerance to environmental stress, which is preferably achieved by altering metabolic activity, as compared to a corresponding non transformed wild type host cell. 30 0258.0.1 The invention further provides an isolated recombinant expression vector comprising a stress related protein encoding nucleic acid as described above, wherein expression of the vector or stress related protein encoding nucleic acid, respectively in a host cell results in increased tolerance and/or resistance to environmental stress, which is preferably achieved by altering metabolic activity, as 35 compared to the corresponding non-transformed wild type of the host cell. As used herein, the term "vector" refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a "plasmid", which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Further types of vectors can be linearized nucleic acid sequences, such as transposons, which are pieces of DNA 5 which can copy and insert themselves. There have been 2 types of transposons found: simple transposons, known as Insertion Sequences and composite transposons, which can have several genes as well as the genes that are required for transposition. 0259.0.1 Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication 10 and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as "expression vectors". In general, expression 15 vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, "plasmid" and "vector" can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which 20 serve equivalent functions. 0260.0.1 A plant expression cassette preferably contains regulatory sequences capable of driving gene expression in plant cells and operably linked so that each sequence can fulfill its function, for example, termination of transcription by polyadenylation signals. Preferred polyadenylation signals are those originating from 25 Agrobacterium tumefaciens T-DNA such as the gene 3 known as octopine synthase of the Ti-plasmid pTiACH5 (Gielen et al., 1984 EMBO J. 3:835) or functional equivalents thereof but also all other terminators functionally active in plants are suitable. 0261.0.1 As plant gene expression is very often not limited on transcriptional levels, a plant expression cassette preferably contains other operably linked sequences 30 like translational enhancers such as the overdrive-sequence containing the 5' untranslated leader sequence from tobacco mosaic virus enhancing the protein per RNA ratio (Gallie et al., 1987 Nucl. Acids Research 15:8693-8711). 0262.0.1 Plant gene expression has to be operably linked to an appropriate promoter conferring gene expression in a timely, cell or tissue specific manner. 35 Preferred are promoters driving constitutive expression (Benfey et al., 1989 EMBO J. 8:2195-2202) like those derived from plant viruses like the 35S CaMV (Franck et al., 1980 Cell 21:285-294), the 19S CaMV (see also U.S. Patent No. 5352605 and PCT Application No. WO 8402913) or plant promoters like those from Rubisco small subunit described in U.S. Patent No. 4,962,028. 0263.0.1 Additional advantageous regulatory sequences are, for example, included in the plant promoters such as CaMV/35S [Franck et al., Cell 21 (1980) 285 5 294], PRP1 [Ward et al., Plant. Mol. Biol. 22 (1993)], SSU, OCS, lib4, usp, STLS1, B33, LEB4, nos or in the ubiquitin, napin or phaseolin promoter. Also advantageous in this connection are inducible promoters such as the promoters described in EP-A-0 388 186 (benzyl sulfonamide inducible), Plant J. 2, 1992: 397 - 404 (Gatz et al., Tetracyclin inducible), EP-A-0 335 528 (abscisic acid inducible) or WO 93/21334 10 (ethanol or cyclohexenol inducible). Additional useful plant promoters are the cytosolic FBPase promotor or ST-LSI promoter of the potato (Stockhaus et al., EMBO J. 8, 1989, 2445), the phosphorybosyl phyrophoshate amido transferase promoter of Glycine max (gene bank accession No. U87999) or the noden specific promoter described in EP-A-0 249 676. Additional particularly advantageous promoters are seed 15 specific promoters which can be used for monokotyledones or dikotyledones and are described in US 5,608,152 (napin promoter from rapeseed), WO 98/45461 (phaseolin promoter from Arobidopsis), US 5,504,200 (phaseolin promoter from Phaseolus vulgaris), WO 91/13980 (Bce4 promoter from Brassica) and Baeumlein et al., Plant J., 2, 2, 1992: 233-239 (LEB4 promoter from leguminosa). Said promoters are useful in 20 dikotyledones. The following promoters are useful for example in monokotyledones Ipt 2- or Ipt-1- promoter from barley (WO 95/15389 and WO 95/23230) or hordein promoter from barley. Other useful promoters are described in WO 99/16890. 0264.0.1 It is possible in principle to use all natural promoters with their regulatory sequences like those mentioned above for the novel process. It is also possible and 25 advantageous in addition to use synthetic promoters. 0265.0.1 The gene construct may also comprise further genes which are to be inserted into the organisms and which are for example involved in stress resistance. It is possible and advantageous to insert and express in host organisms regulatory genes such as genes for inducers, repressors or enzymes which intervene by their enzymatic 30 activity in the regulation, or one or more or all genes of a biosynthetic pathway. These genes can be heterologous or homologous in origin. The inserted genes may have their own promoter or else be under the control of same promoter as the sequences of the nucleic acid of Fig. 1a, 1b or 1c or their homologs. 0266.0.1 The gene construct advantageously comprises, for expression of the 35 other genes present, additionally 3' and/or 5' terminal regulatory sequences to enhance expression, which are selected for optimal expression depending on the selected host organism and gene or genes.

0267.0.1 These regulatory sequences are intended to make specific expression of the genes and protein expression possible as mentioned above. This may mean, depending on the host organism, for example that the gene is expressed or overexpressed only after induction, or that it is immediately expressed and/or 5 overexpressed. 0268.0.1 The regulatory sequences or factors may moreover preferably have a beneficial effect on expression of the introduced genes, and thus increase it. It is possible in this way for the regulatory elements to be enhanced advantageously at the transcription level by using strong transcription signals such as promoters and/or 10 enhancers. However, in addition, it is also possible to enhance translation by, for example, improving the stability of the mRNA. 0269.0.1 Other preferred sequences for use in plant gene expression cassettes are targeting-sequences necessary to direct the gene product in its appropriate cell compartment (for review see Kermode, 1996 Crit. Rev. Plant Sci. 15(4):285-423 and 15 references cited therein) such as the vacuole, the nucleus, all types of plastids like amyloplasts, chloroplasts, chromoplasts, the extracellular space, mitochondria, the endoplasmic reticulum, oil bodies, peroxisomes and other compartments of plant cells. 0270.0.1 Plant gene expression can also be facilitated via an inducible promoter (for review see Gatz, 1997 Annu. Rev. Plant Physiol. Plant Mol. Biol. 48:89-108). 20 Chemically inducible promoters are especially suitable if gene expression is wanted to occur in a time specific manner. 0271.0.1 Table 1 lists several examples of promoters that may be used to regulate transcription of the stress related protein nucleic acid coding sequences. 0272.0.1 Tab. 1: Examples of Tissue-specific and Stress inducible promoters in 25 plants Expression Reference Cor78- Cold, drought, Ishitani, et al., Plant Cell 9:1935-1949 (1997). salt, ABA, wounding inducible Yamaguchi-Shinozaki and Shinozaki, Plant Cell 6:251-264 (1994). Rci2A - Cold, Capel et al., Plant Physiol 115:569-576 (1997) dehydration-inducible Rd22 - Drought, salt Yamaguchi-Shinozaki and Shinozaki, Mol Gen Genet 238:17-25 (1993). Corl5A - Cold, Baker et al., Plant Mol. Biol. 24:701-713 (1994).

dehydration, ABA GH3- Auxin inducible Liu et al., Plant Cell 6:645-657 (1994) ARSK1-Root, salt Hwang and Goodman, Plant J 8:37-43 (1995). inducible PtxA - Root, salt GenBank accession X67427 inducible SbHRGP3 - Root Ahn et al., Plant Cell 8:1477-1490 (1998). specific KST1 - Guard cell Plesch et al., Plant Journal. 28(4):455-64, (2001) specific KAT1 - Guard cell Plesch et al., Gene 249:83-89 (2000) specific Nakamura et al., Plant Physiol. 109:371-374 (1995) salicylic acid PCT Application No. WO 95/19443 inducible tetracycline inducible Gatz et al. Plant J. 2:397-404 (1992) Ethanol inducible PCT Application No. WO 93/21334 pathogen inducible Ward et al., 1993 Plant. Mol. Biol. 22:361-366 PRP1 heat inducible hsp80 U.S. Patent No. 5187267 cold inducible alpha- PCT Application No. WO 96/12814 amylase Wound-inducible pinli European Patent No. 375091 RD29A - salt- Yamaguchi-Shinozalei et al. (1993) Mol. Gen. Genet. inducible 236:331-340 plastid-specific viral PCT Application No. WO 95/16783 and. WO RNA-polymerase 97/06250 0273.0.1 Other promotors, e.g. superpromotor (Ni et al,., Plant Journal 7, 1995: 661-676), Ubiquitin promotor (Callis et al., J. Biol. Chem., 1990, 265: 12486-12493; US 5,510,474; US 6,020,190; Kawalleck et al., Plant. Molecular Biology, 1993, 21: 673 684) or 34S promotor (GenBank Accession numbers M59930 and X16673) were similar useful for the present invention and are known to a person skilled in the art. 0274.0.3 Developmental stage-preferred promoters are preferentially expressed 5 at certain stages of development. Tissue and organ preferred promoters include those that are preferentially expressed in certain tissues or organs, such as leaves, roots, seeds, or xylem. Examples of tissue preferred and organ preferred promoters include, but are not limited to fruit-preferred, ovule-preferred, male tissue-preferred, seed preferred, integument-preferred, tuber-preferred, stalk-preferred, pericarp-preferred, 10 and leaf-preferred, stigma-preferred, pollen-preferred, anther-preferred, a petal preferred, sepal-preferred, pedicel-preferred, silique-preferred, stem-preferred, root preferred promoters, and the like. Seed preferred promoters are preferentially expressed during seed development and/or germination. For example, seed preferred promoters can be embryo-preferred, endosperm preferred, and seed coat-preferred. 15 See Thompson et al., 1989, BioEssays 10:108. Examples of seed preferred promoters include, but are not limited to, cellulose synthase (celA), Cim1, gamma-zein, globulin-1, maize 19 kD zein (cZ19B1), and the like. 0275.0.3 Other promoters useful in the expression cassettes of the invention include, but are not limited to, the major chlorophyll a/b binding protein promoter, 20 histone promoters, the Ap3 promoter, the p-conglycin promoter, the napin promoter, the soybean lectin promoter, the maize 15kD zein promoter, the 22kD zein promoter, the 27kD zein promoter, the g-zein promoter, the waxy, shrunken 1, shrunken 2 and bronze promoters, the Zm13 promoter (U.S. Patent No. 5,086,169), the maize polygalacturonase promoters (PG) (U.S. Patent Nos. 5,412,085 and 5,545,546), and 25 the SGB6 promoter (U.S. Patent No. 5,470,359), as well as synthetic or other natural promoters. 0276.0.3 Additional flexibility in controlling heterologous gene expression in plants may be obtained by using DNA binding domains and response elements from heterologous sources (i.e., DNA binding domains from non-plant sources). An 30 example of such a heterologous DNA binding domain is the LexA DNA binding domain (Brent and Ptashne, 1985, Cell 43:729-736). 0277.0.3 The invention further provides a recombinant expression vector comprising a SRP DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory 35 sequence in a manner that allows for expression (by transcription of the DNA molecule) of an RNA molecule that is antisense to a SRP mRNA. Regulatory sequences operatively linked to a nucleic acid molecule cloned in the antisense orientation can be chosen which direct the continuous expression of the antisense RNA molecule in a variety of cell types. For instance, viral promoters and/or enhancers, or regulatory sequences can be chosen which direct constitutive, tissue specific, or cell type specific expression of antisense RNA. The antisense expression vector can be in the form of a 5 recombinant plasmid, phagemid, or attenuated virus wherein antisense nucleic acids are produced under the control of a high efficiency regulatory region. The activity of the regulatory region can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes, see Weintraub, H. et al., 1986, Antisense RNA as a molecular tool for genetic 10 analysis, Reviews - Trends in Genetics, Vol. 1(1), and Mol et al., 1990, FEBS Letters 268:427-430. 0279.0.3 Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms "host cell" and "recombinant host cell" are used interchangeably herein. It is understood that 15 such terms refer not only to the particular subject cell but they also apply to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein. A host cell can be any prokaryotic or eukaryotic cell. 20 For example, a SRP can be expressed in bacterial cells such as C. glutamicum, yeast, E.coli, insect cells, fungal cells, or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells), algae, ciliates, plant cells, fungi, or other microorganisms like C. glutamicum. Other suitable host cells are known to those skilled in the art. 0280.0.3 A host cell of the invention, such as a prokaryotic or eukaryotic host cell 25 in culture, can be used to produce (i.e., express) a SRP. Accordingly, the invention further provides methods for producing SRPs using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding a SRP has been introduced, or into which genome has been introduced a gene encoding a wild-type or altered SRP) in a suitable 30 medium until SRP is produced. In another embodiment, the method further comprises isolating SRPs from the medium or the host cell. 0281.0.3 Another aspect of the invention pertains to isolated SRPs, and biologically active portions thereof. An "isolated" or "purified" polypeptide or biologically active portion thereof is free of some of the cellular material when produced by 35 recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. The language "substantially free of cellular material" includes preparations of SRP in which the polypeptide is separated from some of the cellular components of the cells in which it is naturally or recombinantly produced. In one embodiment, the language "substantially free of cellular material" includes preparations of a SRP having less than about 30% (by dry weight) of non-SRP material (also referred to herein as a "contaminating polypeptide"), more preferably less than about 5 20% of non-SRP material, still more preferably less than about 10% of non-SRP material, and most preferably less than about 5% non-PKSRP material. 0282.0.3 When the SRP or biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium 10 represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the polypeptide preparation. The language "substantially free of chemical precursors or other chemicals" includes preparations of SRP in which the polypeptide is separated from chemical precursors or other chemicals that are involved in the synthesis of the polypeptide. In one 15 embodiment, the language "substantially free of chemical precursors or other chemicals" includes preparations of a SRP having less than about 30% (by dry weight) of chemical precursors or non-SRP chemicals, more preferably less than about 20% chemical precursors or non-SRP chemicals, still more preferably less than about 10% chemical precursors or non-SRP chemicals, and most preferably less than about 5% 20 chemical precursors or non-SRP chemicals. In preferred embodiments, isolated polypeptides, or biologically active portions thereof, lack contaminating polypeptides from the same organism from which the SRP is derived. Typically, such polypeptides are produced by recombinant expression of, for example, a Saccharomyces cerevisiae, E.coli, Brassica napus, Glycine max, or Oryza sativa SRP in plants other than 25 Saccharomyces cerevisiae, E.coli, Brassica napus, Glycine max, or Oryza sativa, or microorganisms such as C. glutamicum, ciliates, algae or fungi. 0283.0.3 The nucleic acid molecules, polypeptides, polypeptide homologs, fusion polypeptides, primers, vectors, and host cells described herein can be used in one or more of the following methods: identification of Saccharomyces cerevisiae, E.coli, 30 Brassica napus, Glycine max, or Oryza sativa and related organisms; mapping of genomes of organisms related to Saccharomyces cerevisiae, E.coli, Brassica napus, Glycine max, or Oryza sativa; identification and localization of Saccharomyces cerevisiae, E.coli, Brassica napus, Glycine max, or Oryza sativa sequences of interest; evolutionary studies; determination of SRP regions required for function; modulation of 35 a SRP activity; modulation of the metabolism of one or more cell functions; modulation of the transmembrane transport of one or more compounds; modulation of stress resistance; and modulation of expression of SRP nucleic acids.

0284.0.3 The SRP nucleic acid molecules of the invention are also useful for evolutionary and polypeptide structural studies. The metabolic and transport processes in which the molecules of the invention participate are utilized by a wide variety of prokaryotic and eukaryotic cells; by comparing the sequences of the nucleic 5 acid molecules of the present invention to those encoding similar enzymes from other organisms, the evolutionary relatedness of the organisms can be assessed. Similarly, such a comparison permits an assessment of which regions of the sequence are conserved and which are not, which may aid in determining those regions of the polypeptide that are essential for the functioning of the enzyme. This type of 10 determination is of value for polypeptide engineering studies and may give an indication of what the polypeptide can tolerate in terms of mutagenesis without losing function. 0285.0.3 Manipulation of the SRP nucleic acid molecules of the invention may result in the production of SRPs having functional differences from the wild-type SRPs. 15 These polypeptides may be improved in efficiency or activity, may be present in greater numbers in the cell than is usual, or may be decreased in efficiency or activity. 0286.0.3 There are a number of mechanisms by which the alteration of a SRP of the invention may directly affect stress response and/or stress tolerance. In the case of plants expressing SRPs, increased transport can lead to improved salt and/or solute 20 partitioning within the plant tissue and organs. By either increasing the number or the activity of transporter molecules which export ionic molecules from the cell, it may be possible to affect the salt tolerance of the cell. 0287.0.3 The effect of the genetic modification in plants, C. glutamicum, fungi, algae, or ciliates on stress tolerance can be assessed by growing the modified 25 microorganism or plant under less than suitable conditions and then analyzing the growth characteristics and/or metabolism of the plant. Such analysis techniques are well known to one skilled in the art, and include dry weight, wet weight, polypeptide synthesis, carbohydrate synthesis, lipid synthesis, evapotranspiration rates, general plant and/or crop yield, flowering, reproduction, seed setting, root growth, respiration 30 rates, photosynthesis rates, etc. (Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17; Rehm et al., 1993 Biotechnology, vol. 3, Chapter III: Product recovery and purification, page 469-714, VCH: Weinheim; Belter, P.A. et al., 1988, Bioseparations: downstream processing for biotechnology, John Wiley and Sons; Kennedy, J.F. and Cabral, J.M.S., 1992, 35 Recovery processes for biological materials, John Wiley and Sons; Shaeiwitz, J.A. and Henry, J.D., 1988, Biochemical separations, in: Ulmann's Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim; and Dechow, F.J., 1989, Separation and purification techniques in biotechnology, Noyes Publications). 0288.0.3 For example, yeast expression vectors comprising the nucleic acids disclosed herein, or fragments thereof, can be constructed and transformed into 5 Saccharomyces cerevisiae using standard protocols. The resulting transgenic cells can then be assayed for fail or alteration of their tolerance to drought, salt, and temperature stress. Similarly, plant expression vectors comprising the nucleic acids disclosed herein, or fragments thereof, can be constructed and transformed into an appropriate plant cell such as Arabidopsis, soy, rape, maize, wheat, Medicago truncatula, etc., 10 using standard protocols. The resulting transgenic cells and/or plants derived therefrom can then be assayed for fail or alteration of their tolerance to drought, salt, temperature stress, and lodging. 0289.0.3 The engineering of one or more SRP genes of the invention may also result in SRPs having altered activities which indirectly impact the stress response 15 and/or stress tolerance of algae, plants, ciliates, or fungi, or other microorganisms like C. glutamicum. For example, the normal biochemical processes of metabolism result in the production of a variety of products (e.g., hydrogen peroxide and other reactive oxygen species) which may actively interfere with these same metabolic processes. For example, peroxynitrite is known to nitrate tyrosine side chains, thereby inactivating 20 some enzymes having tyrosine in the active site (Groves, J.T., 1999, Curr. Opin. Chem. Biol. 3(2):226-235). While these products are typically excreted, cells can be genetically altered to transport more products than is typical for a wild-type cell. By optimizing the activity of one or more PKSRPs of the invention which are involved in the export of specific molecules, such as salt molecules, it may be possible to improve 25 the stress tolerance of the cell. 0290.0.3 Additionally, the sequences disclosed herein, or fragments thereof, can be used to generate knockout mutations in the genomes of various organisms, such as bacteria, mammalian cells, yeast cells, and plant cells (Girke, T., 1998, The Plant Journal 15:39-48). The resultant knockout cells can then be evaluated for their ability 30 or capacity to tolerate various stress conditions, their response to various stress conditions, and the effect on the phenotype and/or genotype of the mutation. For other methods of gene inactivation, see U.S. Patent No. 6,004,804 "Non-Chimeric Mutational Vectors" and Puttaraju et al., 1999, Spliceosome-mediated RNA trans-splicing as a tool for gene therapy, Nature Biotechnology 17:246-252. 35 0291.0.3 The aforementioned mutagenesis strategies for SRPs resulting in increased stress resistance are not meant to be limiting; variations on these strategies will be readily apparent to one skilled in the art. Using such strategies, and incorporating the mechanisms disclosed herein, the nucleic acid and polypeptide molecules of the invention may be utilized to generate algae, ciliates, plants, fungi, or other microorganisms like C. glutamicum expressing mutated PKSRP nucleic acid and polypeptide molecules such that the stress tolerance is improved. 5 0292.0.3 The present invention also provides antibodies that specifically bind to a SRP, or a portion thereof, as encoded by a nucleic acid described herein. Antibodies can be made by many well-known methods (See, e.g. Harlow and Lane, "Antibodies; A Laboratory Manual," Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, (1988)). Briefly, purified antigen can be injected into an animal in an amount and in 10 intervals sufficient to elicit an immune response. Antibodies can either be purified directly, or spleen cells can be obtained from the animal. The cells can then fused with an immortal cell line and screened for antibody secretion. The antibodies can be used to screen nucleic acid clone libraries for cells secreting the antigen. Those positive clones can then be sequenced. See, for example, Kelly et al., 1992, Bio/Technology 15 10:163-167; Bebbington et al., 1992, Bio/Technology 10:169-175. 0293.0.3 The phrases "selectively binds" and "specifically binds" with the polypeptide refer to a binding reaction that is determinative of the presence of the polypeptide in a heterogeneous population of polypeptides and other biologics. Thus, under designated immunoassay conditions, the specified antibodies bound to a 20 particular polypeptide do not bind in a significant amount to other polypeptides present in the sample. Selective binding of an antibody under such conditions may require an antibody that is selected for its specificity for a particular polypeptide. A variety of immunoassay formats may be used to select antibodies that selectively bind with a particular polypeptide. For example, solid-phase ELISA immunoassays are routinely 25 used to select antibodies selectively immunoreactive with a polypeptide. See Harlow and Lane, "Antibodies, A Laboratory Manual," Cold Spring Harbor Publications, New York, (1988), for a description of immunoassay formats and conditions that could be used to determine selective binding. 0294.0.3 In some instances, it is desirable to prepare monoclonal antibodies from 30 various hosts. A description of techniques for preparing such monoclonal antibodies may be found in Stites et al., eds., "Basic and Clinical Immunology," (Lange Medical Publications, Los Altos, Calif., Fourth Edition) and references cited therein, and in Harlow and Lane, "Antibodies, A Laboratory Manual," Cold Spring Harbor Publications, New York, (1988). 35 0295.0.1 Gene expression in plants is regulated by the interaction of protein transcription factors with specific nucleotide sequences within the regulatory region of a gene. A common type of transcription factor contains zinc finger (ZF) motifs. Each ZF module is approximately 30 amino acids long folded around a zinc ion. The DNA recognition domain of a ZF protein is a a-helical structure that inserts into the major grove of the DNA double helix. The module contains three amino acids that bind to the DNA with each amino acid contacting a single base pair in the target DNA sequence. 5 ZF motifs are arranged in a modular repeating fashion to form a set of fingers that recognize a contiguous DNA sequence. For example, a three-fingered ZF motif will recognize 9 bp of DNA. Hundreds of proteins have been shown to contain ZF motifs with between 2 and 37 ZF modules in each protein (Isalan M, et al., 1998 Biochemistry 37(35):12026-33; Moore M, et al., 2001 Proc. NatI. Acad. Sci. USA 98(4):1432-1436 10 and 1437-1441; US patents US 6007988 and US 6013453). 0296.0.1 The regulatory region of a plant gene contains many short DNA sequences (cis-acting elements) that serve as recognition domains for transcription factors, including ZF proteins. Similar recognition domains in different genes allow the coordinate expression of several genes encoding enzymes in a metabolic pathway by 15 common transcription factors. Variation in the recognition domains among members of a gene family facilitates differences in gene expression within the same gene family, for example, among tissues and stages of development and in response to environmental conditions. 0297.0.1 Typical ZF proteins contain not only a DNA recognition domain but also 20 a functional domain that enables the ZF protein to activate or repress transcription of a specific gene. Experimentally, an activation domain has been used to activate transcription of the target gene (US patent 5789538 and patent application W09519431), but it is also possible to link a transcription repressor domain to the ZF and thereby inhibit transcription (patent applications WO00/47754 and 25 W02001002019). It has been reported that an enzymatic function such as nucleic acid cleavage can be linked to the ZF (patent application WO00/20622) 0298.0.1 The invention provides a method that allows one skilled in the art to isolate the regulatory region of one or more stress related protein encoding genes from the genome of a plant cell and to design zinc finger transcription factors linked to a 30 functional domain that will interact with the regulatory region of the gene. The interaction of the zinc finger protein with the plant gene can be designed in such a manner as to alter expression of the gene and preferably thereby alter metabolic activity to confer increased (or decreased) tolerance of abiotic stress such as drought. The invention provides a method of producing a transgenic plant with a transgene 35 encoding this designed transcription factor, or alternatively a natural transcription factor, that modifies transcription of the Stress-Related Protein, particularly stress related protein gene to provide increased tolerance of environmental stress, which is preferably achieved by altering metabolic activity. Such a regulation of plant genes by artificial polydactyl zinc fingers has been demonstrated by Ordiz et al.(Regulation of transgene Expression in plants with polydactyl zinc finger transcription factors, Ordiz et al., PNAS ,99 (20) 13290-13295, 2002) or Guan et al. (Hertiable endogenous gene 5 regulation in plants with designed polydactyl zinc finger transcription factos, PNAS, Vol. 99 (20), 13296-13301 (2002)). 0299.0.1 In particular, the invention provides a method of producing a transgenic plant with a stress related protein coding nucleic acid, wherein expression of the nucleic acid(s) in the plant results in increased tolerance to environmental stress, which 10 is preferably achieved by altering metabolic activity, as compared to a wild type plant comprising: (a) transforming a plant cell with an expression vector comprising a stress related protein encoding nucleic acid, and (b) generating from the plant cell a transgenic plant with an increased tolerance to environmental stress as compared to a wild type plant. For such plant transformation, binary vectors such as pBinAR can be 15 used (Hbfgen and Willmitzer, 1990 Plant Science 66:221-230). Moreover suitable binary vectors are for example pBIN19, pBI101, pGPTV or pPZP (Hajukiewicz, P. et al., 1994, Plant Mol. Biol., 25: 989-994). 0300.0.1 Construction of the binary vectors can be performed by ligation of the cDNA into the T-DNA. 5' to the cDNA a plant promoter activates transcription of the 20 cDNA. A polyadenylation sequence is located 3' to the cDNA. Tissue-specific expression can be achieved by using a tissue specific promoter as listed above. Also, any other promoter element can be used. For constitutive expression within the whole plant, the CaMV 35S promoter can be used. The expressed protein can be targeted to a cellular compartment using a signal peptide, for example for plastids, mitochondria or 25 endoplasmic reticulum (Kermode, 1996 Crit. Rev. Plant Sci. 4(15):285-423). The signal peptide is cloned 5' in frame to the cDNA to archive subcellular localization of the fusion protein. Additionally, promoters that are responsive to abiotic stresses can be used with, such as the Arabidopsis promoter RD29A. One skilled in the art will recognize that the promoter used should be operatively linked to the nucleic acid such 30 that the promoter causes transcription of the nucleic acid which results in the synthesis of a mRNA which encodes a polypeptide. 0301.0.1 Alternate methods of transfection include the direct transfer of DNA into developing flowers via electroporation or Agrobacterium mediated gene transfer. Agrobacterium mediated plant transformation can be performed using for example the 35 GV3101(pMP90) (Koncz and Schell, 1986 Mol. Gen. Genet. 204:383-396) or LBA4404 (Ooms et al., Plasmid, 1982, 7: 15-29; Hoekema et al., Nature, 1983, 303: 179-180) Agrobacterium tumefaciens strain. Transformation can be performed by standard transformation and regeneration techniques (Deblaere et al., 1994 Nucl. Acids. Res. 13:4777-4788; Gelvin and Schilperoort, Plant Molecular Biology Manual, 2nd Ed. Dordrecht : Kluwer Academic Publ., 1995. - in Sect., Ringbuc Zentrale Signatur: BT11 P ISBN 0-7923-2731-4; Glick, B R and Thompson, J E, Methods in Plant Molecular 5 Biology and Biotechnology, Boca Raton : CRC Press, 1993. - 360 S., ISBN 0-8493 5164-2). For example, rapeseed can be transformed via cotyledon or hypocotyl transformation (Moloney et al., 1989 Plant Cell Reports 8:238-242; De Block et al., 1989 Plant Physiol. 91:694-701). Use of antibiotics for Agrobacterium and plant selection depends on the binary vector and the Agrobacterium strain used for 10 transformation. Rapeseed selection is normally performed using kanamycin as selectable plant marker. Agrobacterium mediated gene transfer to flax can be performed using, for example, a technique described by Mlynarova et al., 1994 Plant Cell Report 13:282-285. Additionally, transformation of soybean can be performed using for example a technique described in European Patent No. 0424 047, U.S. 15 Patent No. 5,322,783, European Patent No. 0397 687, U.S. Patent No. 5,376,543 or U.S. Patent No. 5,169,770. Transformation of maize can be achieved by particle bombardment, polyethylene glycol mediated DNA uptake or via the silicon carbide fiber technique (see, for example, Freeling and Walbot "The maize handbook" Springer Verlag: New York (1993) ISBN 3-540-97826-7). A specific example of maize 20 transformation is found in U.S. Patent No. 5,990,387 and a specific example of wheat transformation can be found in PCT Application No. WO 93/07256. 0302.0.1 The stress related protein encoding nucleic acid molecules of the invention have a variety of uses. Most importantly, the nucleic acid and amino acid sequences of the present invention can be used to transform plant cells or plants, 25 thereby inducing tolerance to stresses such as drought, high salinity and cold. The present invention therefore provides a transgenic plant transformed by a stress related protein encoding nucleic acid (coding or antisense), wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type plant. The increased stress tolerance is apparent as an 30 increase in the yield or quality of the plant. The transgenic plant can be a monocot or a dicot or a gymnosperm plant. The invention further provides that the transgenic plant can be selected from maize, wheat, rye, oat, triticale, rice, barley, soybean, peanut, cotton, borage, sufflower, linseed, primrose, rapeseed, canola and turnip rape, manihot, pepper, sunflower, tagetes, solanaceous plant such as potato, tobacco, 35 eggplant and tomato, Vicia species, pea, alfalfa, bushy plants such as coffee, cacao, tea, Salix species, trees such as oil palm, coconut, perennial grass, such as ryegrass and fescue, and forage crops, such as alfalfa and clover and Arabidopsis thaliana. Further the transgenic plant can be selected from spruce, pine or fir for example. 0303.0.1 In particular, the present invention describes using the expression of stress related proteins to engineer drought-tolerant, salt-tolerant and/or cold-tolerant 5 plants. This strategy has herein been demonstrated for Arabidopsis thaliana, Ryegrass, Alfalfa, Rapeseed/Canola, Soybean, Corn and Wheat but its application is not restricted to these plants. Accordingly, the invention provides a transgenic plant containing a stress related protein encoding gene selected from the nucleic acid of Fig. la, lb or 1c and/or homologs of the afore mentioned sequences, wherein the 10 environmental stress is drought, increased salt or decreased or increased temperature but its application is not restricted to these adverse environments. Protection against other adverse conditions such as heat, air pollution, heavy metals and chemical toxicants, for example, may be obtained. In preferred embodiments, the environmental stress is drought. 15 0304.0.1 The present invention also provides methods of modifying stress tolerance of a plant comprising, modifying the expression of a stress related protein encoding gene in the plant. The invention provides that this method can be performed such that the stress tolerance is increased. This can for example be done by the use of transcription factors. In particular, the present invention provides methods of producing 20 a transgenic plant having an increased tolerance to environmental stress as compared to a wild type plant due to increased expression of a stress related protein in the plant. 0305.0.1 Growing the modified plants under stress conditions and then screening and analyzing the growth characteristics and/or metabolic activity assess the effect of the genetic modification in plants on stress tolerance and/or resistance. Such analysis 25 techniques are well known to one skilled in the art. They include next to screening (Rbmpp Lexikon Biotechnologie, Stuttgart/New York: Georg Thieme Verlag 1992, "screening" p. 701) dry weight, wet weight, protein synthesis, carbohydrate synthesis, lipid synthesis, evapotranspiration rates, general plant and/or crop yield, flowering, reproduction, seed setting, root growth, respiration rates, photosynthesis rates, etc. 30 (Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17; Rehm et al., 1993 Biotechnology, vol. 3, Chapter III: Product recovery and purification, page 469-714, VCH: Weinheim; Belter, P.A. et al., 1988 Bioseparations: downstream processing for biotechnology, John Wiley and Sons; Kennedy, J.F. and Cabral, J.M.S., 1992 Recovery processes for biological materials, 35 John Wiley and Sons; Shaeiwitz, J.A. and Henry, J.D., 1988 Biochemical separations, in: Ulmann's Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim; and Dechow, F.J. (1989) Separation and purification techniques in biotechnology, Noyes Publications). 0306.0.1 The engineering of one or more stress related protein encoding genes of the invention may also result in stress related proteins having altered activities which 5 indirectly impact the stress response and/or stress tolerance of plants. For example, the normal biochemical processes of metabolism result in the production of a variety of products (e.g., hydrogen peroxide and other reactive oxygen species) which may actively interfere with these same metabolic processes (for example, peroxynitrite is known to react with tyrosine side chains, thereby inactivating some enzymes having 10 tyrosine in the active site (Groves, J.T., 1999 Curr. Opin. Chem. Biol. 3(2):226-235). By optimizing the activity of one or more stress related proteins (enzymes) of the invention, it may be possible to improve the stress tolerance of the cell. 0307.0.1 Throughout this application, various publications are referenced. The disclosures of all of these publications and those references cited within those 15 publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains. 0308.0.1 It should also be understood that the foregoing relates to preferred embodiments of the present invention and that numerous changes and variations may be made therein without departing from the scope of the invention. The invention is 20 further illustrated by the following examples, which are not to be construed in any way as limiting. On the contrary, it is to be clearly understood that various other embodiments, modifications and equivalents thereof, which, after reading the description herein, may suggest themselves to those skilled in the art without departing from the spirit of the present invention and/or the scope of the claims. 25 0309.0.1 The invention also pertains to the use of SRP encoding nucleic acid selected form the group comprising the nucleic acid of Fig. la, lb or 1c and/or homologs of the afore mentioned sequences for preparing a plant cell with increased environmental stress tolerance, which is preferably achieved by altering metabolic activity. The said sequences can also be used for preparing a plant with increased 30 environmental stress tolerance. 0310.0.1 Object of the invention is further the use of altered metabolic activity and/or a SRP encoding nucleic acid selected form the group of sequences of the nucleic acid of Fig. 1a, lb or 1c and/or homologs of the afore mentioned sequences or parts thereof as markers for selection of plants with increased tolerance to 35 environmental stress or as markers for detection of stress in plants or plant cells. 0311.0.1 Example 1 0312.0.1 Engineering stress-tolerant Arabidopsis plants by over-expressing stress related protein genes. 0313.0.1 Gene cloning and transformation of Arabidopsis thaliana 0314.0.1 Amplification 5 0315.0.1 The standard protocol of Pfu DNA polymerase or a Pfu/Taq DNA polymerase mix (Herculase) was used for the amplification procedure. Amplified ORF fragments were analysed by gel electrophoresis. Each primer consists of a universal 5 'end and ORF specific 3' end whereby the universal sequences differ for the forward and reverse primers (forward primer sequence contains an EcoRI for yeast or Smal for 10 E.coli and the reverse primer sequence a Smal for yeast or Sacl for E.coli restriction site) allowing generally a unidirectional cloning success. 0316.0.1 Amplification using the protocol of Pfu or Herculase DNA polymerase (Stratagene). Conditions: 1x PCR buffer, 0.2 mM dNTP, 100 ng genomic DNA Saccharomyces cerevisiae (S288C) or 60 ng genomic DNA Escherichia coli K-12 15 (MG1655), 25 pmol forward primer, 25 pmol reverse primer, 2.5 u Pfu or Herculase DNA polymerase. 1st cycle for 3' for yeast of 2' for E.coli at 94 'C, followed by 25 cycles for 30' at 94 'C, 30' 55'C for yeast or 600C for E.coli and 5-6' 72 OC, followed by 1 cycle for 610' at 72 OC, final for 4 OC at oo. 0317.0.1 Table 2: Forward and reverse primer sequences used for ORF 20 amplification Gene Forward Seq YGL263W GGAATTCCAGCTGACCACCATGGATGGAGCCAAATTTGAAAATAC YGRO04W GGAATTCCAGCTGACCACCATGAGCGAAATAAATAATGAAAATCTAG YGRO14W GGAATTCCAGCTGACCACCATGCAGTTTCCATTCGCTTGTCTC YGL239C GGAATTCCAGCTGACCACCATGAAATTTTTGAAGAACAAAGCACC YBL060W GGAATTCCAGCTGACCACCATGTGCGCCAGTTTAAACGAGGTA YGL166W GGAATTCCAGCTGACCACCATGGTCGTAATTAACGGGGTCAAAT YDL202W GGAATTCCAGCTGACCACCATGTTGCAGCTAAGGTTTATGCCT YALO46C GGAATTCCAGCTGACCACCATGAAGCTCCCACAGACCATGCT YDR101C GGAATTCCAGCTGACCACCATGGCTCTAGCTATCTCCCACGA YDR108W GGAATTCCAGCTGACCACCATGGTTTTTTCTTATGAGCACTATATG YAL064W GGAATTCCAGCTGACCACCATGCGATATACTGCAACTTTTCGG YDR134C GGAATTCCAGCTGACCACCATGCAATTCTCTACCGTCGCTTCT YFLO31w GGAATTCCAGCTGACCACCATGAATAGCGAGTACGATTACCTGT YFL052W GGAATTCCAGCTGACCACCATGGCCCGCAATAGACAAGCGT YFLO42C GGAATTCCAGCTGACCACCATGTCGGATGTAGATAACTGGGAA YBR025C GGAATTCCAGCTGACCACCATGCCTCCAAAGAAGCAAGTCGAA YER174C GGAATTCCAGCTGACCACCATGACTGTGGTTGAAATAAAAAGCC YBR051W GGAATTCCAGCTGACCACCATGCACATTCTTTTCTTGTTTATTTTC YER175C GGAATTCCAGCTGACCACCATGTCTACCTTTTCTGCTTCTGATT YDR521W GGAATTCCAGCTGACCACCATGAAAGGTTCAAAATCGCACCTTG YER167W GGAATTCCAGCTGACCACCATGCCGAAGAATAGTCACCACCAT YER123W GGAATTCCAGCTGACCACCATGTCCCAACGATCTTCACAACAC YDR415C GGAATTCCAGCTGACCACCATGGCCGATGAGGAACGTTTAAAG YEL052W GGAATTCCAGCTGACCACCATGATCGCTTTGAAGCCCAATGCT YDR536W GGAATTCCAGCTGACCACCATGAAGGATTTAAAATTATCGAATTTCA YDR513W GGAATTCCAGCTGACCACCATGGAGACCAATTTTTCCTTCGACT YEL045C GGAATTCCAGCTGACCACCATGAAATGTCACGCGAAACGGAC YEL041W GGAATTCCAGCTGACCACCATGAAAACTGATAGATTACTGATTAAC YDL238C GGAATTCCAGCTGACCACCATGACAAAAAGTGATTTATTATTTGATAA YBR282W GGAATTCCAGCTGACCACCATGAAAGGCTCACCCATTTCTCAAT YBR258C GGAATTCCAGCTGACCACCATGGCGTATAATCAAGAAGATAGTAA YCLC01W-A GGAATTCCAGCTGACCACCATGACCTTTTTACAATTTATCAATAATAATA YBR274W GGAATTCCAGCTGACCACCATGAGTCTCTCGCAGGTGTCAC YHR090C GGAATTCCAGCTGACCACCATGGATCCAAGTTTAGTTTTAGAGC YGR121C GGAATTCCAGCTGACCACCATGGAGAGTCGAACTACAGGGC YGR127W GGAATTCCAGCTGACCACCATGTGCATTTTAATGGCCACAAGG YGR150C GGAATTCCAGCTGACCACCATGTACATGGCCAGATGTGGCC YKLO37W GGAATTCCAGCTGACCACCATGCAGACAATGGGCGGGGAG YKLO51W GGAATTCCAGCTGACCACCATGATTCAATTTAAAAGTCCAGGTAAC YKL120W GGAATTCCAGCTGACCACCATGTCATCTGACAACTCTAAACAAG YKLO11C GGAATTCCAGCTGACCACCATGTCGACAGCACAGAAAGCTAAG YKLO17C GGAATTCCAGCTGACCACCATGAACAAAGAATTGGCTTCTAAGTT YKLO49C GGAATTCCAGCTGACCACCATGGAAACTGAAGTACCTGCACCA YKL132C GGAATTCCAGCTGACCACCATGGATGATATAAGCGGAAGGCAAA YGR126W GGAATTCCAGCTGACCACCATGCCTGTCCCATCTGTTACTGT YKL070W GGAATTCCAGCTGACCACCATGTACATTCCTAAACATTTTGAGTC YKLO58W GGAATTCCAGCTGACCACCATGGCAGTACCCGGGTATTACGA YHR130C GGAATTCCAGCTGACCACCATGACTAAAAGTATATATATTATCATCG YIL070C GGAATTCCAGCTGACCACCATGTTCTTAAGAAGCGTTAACCGTG YHR195W GGAATTCCAGCTGACCACCATGACTCGTCCCCCATTGGTTC YIR022W GGAATTCCAGCTGACCACCATGAATCTAAGATTTGAATTGCAGAAA YJL089W GGAATTCCAGCTGACCACCATGGCCAAGAGGAAATATGGCAG YJL172W GGAATTCCAGCTGACCACCATGATCGCCTTACCAGTAGAGAAG YHR1 13W GGAATTCCAGCTGACCACCATGTTCAGGATACAACTGAGAACTA YHR175W GGAATTCCAGCTGACCACCATGGATGATAAGAAAACATGGAGTAC YGR212W GGAATTCCAGCTGACCACCATGAATCTTAAACTTTCTGCTATTGAA YJL024C GGAATTCCAGCTGACCACCATGATTCATGCAGTTCTAATATGTATG YGR180c GGAATTCCAGCTGACCACCATGGAAGCACATAACCAATTTTTGAA YJL179W GGAATTCCAGCTGACCACCATGTCACAGATAGCACAAGAAATGA YJL001W GGAATTCCAGCTGACCACCATGAATGGAATTCAAGTGGACATCA YJL208C GGAATTCCAGCTGACCACCATGTGCAGTAGGATACTCTTGTCC YJL152W GGAATTCCAGCTGACCACCATGCCGCATTTAGCCGCCGAAG YJL131C GGAATTCCAGCTGACCACCATGTTAAAAGTTCCTTTGAGTGATGT YJL151C GGAATTCCAGCTGACCACCATGGACAGAGACCATATTAATGACC YLR441 C GGAATTCCAGCTGACCACCATGGCTGTCGGAAAGAATAAGAGA YLR415C GGAATTCCAGCTGACCACCATGTATCTCAGTGCCCAGCTTATG YLR212C GGAATTCCAGCTGACCACCATGGGTGGAGAAATTATTACTTTGC YLR029C GGAATTCCAGCTGACCACCATGGGTGCCTACAAATATTTGGAAG YLLO41C GGAATTCCAGCTGACCACCATGTTGAACGTGCTATTGAGAAGGA YLR105C GGAATTCCAGCTGACCACCATGTCTAAAGGGAGGGTCAATCAG YIL136W GGAATTCCAGCTGACCACCATGTCATCAAGAATAATTGTCGGCA YLR215C GGAATTCCAGCTGACCACCATGTCCTCACAAGAATATACAACTTT YLR321C GGAATTCCAGCTGACCACCATGTCGCACCAAAACCAGCTTATT YMR260C GGAATTCCAGCTGACCACCATGGGTAAGAAAAACACTAAAGGTG YNL120C GGAATTCCAGCTGACCACCATGATAAAAGTCGATACTTCCGATG YLR407W GGAATTCCAGCTGACCACCATGACTGTTTCTACTTCCAAGACC YMR197C GGAATTCCAGCTGACCACCATGAGTTCCCTATTAATATCATACGA YMR10OW GGAATTCCAGCTGACCACCATGAGAGACTCTAATCATCGATCAT YMR21oW GGAATTCCAGCTGACCACCATGCGTCTAAAAGAATTGTTACCTAA YMR318C GGAATTCCAGCTGACCACCATGTCTTATCCTGAGAAATTTGAAGG YMR069W GGAATTCCAGCTGACCACCATGCGTTCTTCGGTATATAGTGAGA YNL076W GGAATTCCAGCTGACCACCATGTCGCGGGAGGCATTTGATGT YNL024C GGAATTCCAGCTGACCACCATGGAGAGTATATTTGGTGGGTTTG YNL125C GGAATTCCAGCTGACCACCATGTCAACGCACTCAAACGACTAC YNL029C GGAATTCCAGCTGACCACCATGTTGCTAATAAGAAGGACGATAAA YMR1 15W GGAATTCCAGCTGACCACCATGCTTTTACAAGGAATGCGTTTATC YNL244C GGAATTCCAGCTGACCACCATGTCCATTGAGAATCTGAAATCATT YNL334C GGAATTCCAGCTGACCACCATGACCGTCGTTATCGGAGTCTT YNRO18W GGAATTCCAGCTGACCACCATGAAGATTTTAACCCAAGACGAAAT YNL277W GGAATTCCAGCTGACCACCATGTCGCATACTTTAAAATCGAAAAC YOL1 18C GGAATTCCAGCTGACCACCATGTCTTTTAGAAAGAAAAAACTCAAAC YOL123W GGAATTCCAGCTGACCACCATGAGCTCTGACGAAGAAGATTTCA YOR020C GGAATTCCAGCTGACCACCATGTCCACCCTTTTGAAGTCTGCT YOL 116W GGAATTCCAGCTGACCACCATGGCAAGTAACCAGCACATAGGA YOR305w GGAATTCCAGCTGACCACCATGATAAAAAACTATTTGGGACGAAG YPL267W GGAATTCCAGCTGACCACCATGATATCACCATCAAAAAAGAGAAC YPL229w GGAATTCCAGCTGACCACCATGATGCCCTACAACACCCCTC YPLO38W GGAATTCCAGCTGACCACCATGAAACTGGCGCAAGACATGAAT YPR047W GGAATTCCAGCTGACCACCATGGAGGTAACTTCAATGTTTCTCA YPL011C GGAATTCCAGCTGACCACCATGACTACAAATAATGACTTCTATTTTG YPR148C GGAATTCCAGCTGACCACCATGTCTGGTTATTTTTCAGGGTTTTC YOL103W GGAATTCCAGCTGACCACCATGGCTGAAATGAAGAATTCGACAG YOR016C GGAATTCCAGCTGACCACCATGCGCGTTTTTACTTTGATTGCGA YPLO79W GGAATTCCAGCTGACCACCATGGGTAAATCGTATGTCCATATAAC YOR260W GGAATTCCAGCTGACCACCATGTCAATTCAGGCTTTTGTCTTTTG YOR360C GGAATTCCAGCTGACCACCATGTCCACCCTTTTTCTGATTGGAA YDL060W GGAATTCCAGCTGACCACCATGGCAGGTCATTCACACAGGTC YDL005C GGAATTCCAGCTGACCACCATGGTAGTACAAAATAGCCCAGTTT YPL210C GGAATTCCAGCTGACCACCATGAAAGAAAGCAAAAAAATGGCTAAA YMR1 18C GGAATTCCAGCTGACCACCATGAAAGCAACCATTCAAAGAGTAAC YPRO52C GGAATTCCAGCTGACCACCATGGTCACCCCAAGAGAACCTAA YLR224W GGAATTCCAGCTGACCACCATGAATCAGAGCGATAGCAGCTTG YLR275W GGAATTCCAGCTGACCACCATGTCGTATGTTTGATCTTAACCATT YMR154C GGAATTCCAGCTGACCACCATGAATGATTGGCATGAGTTCAATG YDR205w GGAATTCCAGCTGACCACCATGGATAGAGGCAGGTGGTGTTT YPR037C GGAATTCCAGCTGACCACCATGAAACAGATAGTCAAAAGAAGCC YNRO08W GGAATTCCAGCTGACCACCATGGGCACACTGTTTCGAAGAAAT YOR084W GGAATTCCAGCTGACCACCATGGAACAGAACAGGTTCAAGAAAG YGRO54W GGAATTCCAGCTGACCACCATGTCATCTCAGTTTTTCCTGAAAAC YGL106W GGAATTCCAGCTGACCACCATGTCAGCCACCAGAGCCAATAAA YAL067C GGAATTCCAGCTGACCACCATGTATTCAATTGTTAAAGAGATTATTG YIL023c GGAATTCCAGCTGACCACCATGAAGGCGTCGCACATTTGCTC YBR064W GGAATTCCAGCTGACCACCATGGATATGGTATCACCAGTCTTGA bOO19 TTGCTCTTCCATGAAACATCTGCATCGATTCTTTAG b2148 TTGCTCTTCCATGAGTGCGTTAAATAAGAAAAG b2796 TTGCTCTTCCATGGAAACGACTCAAACCAGCAC b2082 TTGCTCTTCCATGTTTCATTGTCCTTTATGCCAGC b0124 TTGCTCTTCCATGGCAATTAACAATACAGGCTCG b3116 TTGCTCTTCCATGAGTACTTCAGATAGCATTGTATC b1830 TTGCTCTTCCATGAACATGTTTTTTAGGCTTACC b1453 TTGCTCTTCCATGTTCATGGCAACTTATATGACTTTT b2664 TTGCTCTTCCATGATCAGGAGTCACACCATGA b2799 TTGCTCTTCCATGATGGCTAACAGAATGATTCTGA b3327 TTGCTCTTCCATGAATTATCGCTATCGCGCCA b0970 TTGCTCTTCCATGGATCGTATTGTTAGTTCTTCAC YER003C GGAATTCCAGCTGACCACCATGTCCAACAAGCTGTTCAGGTTA YCLO27W GGAATTCCAGCTGACCACCATGGTAGCAACAATAATGCAGACGA YBR1 12C GGAATTCCAGCTGACCACCATGAATCCGGGCGGTGAACAAAC YNL079C GGAATTCCAGCTGACCACCATGGACAAAATCAGAGAAAAGCTAAG YFRO42W GGAATTCCAGCTGACCACCATGGCAGGTATCAAGTTGACGCAT YER137C GGAATTCCAGCTGACCACCATGTGTGAATCATCAAATAAGACTGA YKL103C GGAATTCCAGCTGACCACCATGGAGGAACAACGTGAAATACTG YNL090W GGAATTCCAGCTGACCACCATGTCTGAAAAGGCCGTTAGAAGG YGR161C GGAATTCCAGCTGACCACCATGATCGCTACCTCCAGAGCCG YDR071 C GGAATTCCAGCTGACCACCATGGCCTCCTCAAGTAGCACGC Gene Reverse Seq YGL263W GATCCCCGGGAATTGCCATGTTACACATCATTGCAAGCTGATTGT YGRO04W GATCCCCGGGAATTGCCATGTTATAGAGAAGGAGACATTGAAACAT YGRO14W GATCCCCGGGAATTGCCATGTCAAACTTCGTTCCAACCCAGGG YGL239C GATCCCCGGGAATTGCCATGTCAATTGCAGGGATTATGGAATAAAA YBL060W GATCCCCGGGAATTGCCATGTTAGAACTGAACAGAACCCATGGC YGL166W GATCCCCGGGAATTGCCATGTTATTGTGAATGTGAGTTATGCGAAG YDL202W GATCCCCGGGAATTGCCATGTTACTTTGATCCCTTCGATTCTGCA YAL046C GATCCCCGGGAATTGCCATGTCATGATGATGCCGGACCCTTC YDR101C GATCCCCGGGAATTGCCATGCTACATTTTCATGGTTTCTTCAACTC YDR108W GATCCCCGGGAATTGCCATGTCATCCAATAAAGCTAACACTTGTTC YAL064W GATCCCCGGGAATTGCCATGCTATGGTTCGCTATTCAATATTAGAA YDR134C GATCCCCGGGAATTGCCATGTTACAACAATAAAGCGGCAGCACC YFL031w GATCCCCGGGAATTGCCATGTCAACAGCAGCCCCCACCGGT YFL052W GATCCCCGGGAATTGCCATGTTAAGGAAGCGCATCTACATCTTCT YFL042C GATCCCCGGGAATTGCCATGTCAACCATACCTTTGATCCAACTG YBR025C GATCCCCGGGAATTGCCATGTCAATTCTTACCAGCACCAGCTCT YER174C GATCCCCGGGAATTGCCATGTTACTGTAGAGCATGTTGGAAATATT YBR051W GATCCCCGGGAATTGCCATGTTATATATGGCATGTCTTCGCATGT YER175C GATCCCCGGGAATTGCCATGTCAGACCCTTTTGCCAAGTTTGTAA YDR521W GATCCCCGGGAATTGCCATGTTACTCACCATTAAAACATCTTTCCC YER167W GATCCCCGGGAATTGCCATGTTAGTTGCTATTATCAAAATAAAAAGAC YER123W GATCCCCGGGAATTGCCATGTCAAAAAAAAAAAGGAAAAAGAGAAAAG YDR415C GATCCCCGGGAATTGCCATGTCACATTTTTCTAAATTCACTTAGCAC YEL052W GATCCCCGGGAATTGCCATGTTAGTATGTAGGCTTAGTAACCCAA YDR536W GATCCCCGGGAATTGCCATGTCAACCCTCAAAATTTGCTTTATCG YDR513W GATCCCCGGGAATTGCCATGCTATTGAAATACCGGCTTCAATATTT YEL045C GATCCCCGGGAATTGCCATGCTAGGAAAGGAGGTGGTTACGAA YEL041W GATCCCCGGGAATTGCCATGTTAGATTGCAAAATGAGCCTGACGA YDL238C GATCCCCGGGAATTGCCATGCTAAATCTGGTAGACTTGCTGGC YBR282W GATCCCCGGGAATTGCCATGTTATCCACGCTCCTTATAACATGAA YBR258C GATCCCCGGGAATTGCCATGTTACGTACTTCCATTTGCTTCCTCT YCL001W-A GATCCCCGGGAATTGCCATGTCAGTTCATCAAAATTGAAATTTCTAACCA YBR274W GATCCCCGGGAATTGCCATGTCAGTTGGGAATTAGGATAATATCC YHR090C GATCCCCGGGAATTGCCATGTCAGTTACGTTTTCTTTTCAGTTTGT YGR121C GATCCCCGGGAATTGCCATGTTACCTATTGGCAGGATCTTCTTGA YGR127W GATCCCCGGGAATTGCCATGTTACAATTTGAATTTAAACCTTTTTTCC YGR150C GATCCCCGGGAATTGCCATGCTACATGTTAAGTTCTTGTTCCTCC YKL037W GATCCCCGGGAATTGCCATGTTATATACTCAATCCAAAACAGGGAA YKL051W GATCCCCGGGAATTGCCATGTCATACGACTACTTGAATAGATTCG YKL120W GATCCCCGGGAATTGCCATGTTAATTATGGCCTAAAACTCTCGAC YKL011C GATCCCCGGGAATTGCCATGTTAGTCATTGTTGTAAGTGTTCTGC YKLO17C GATCCCCGGGAATTGCCATGTTACAAATAATCGTCAATGTTGGGG YKLO49C GATCCCCGGGAATTGCCATGCTAAATAAACTGTCCCCTGATTCTT YKL132C GATCCCCGGGAATTGCCATGCTATACTGGCAAGTGACAGTTGTG YGR126W GATCCCCGGGAATTGCCATGTTAATCGAAAATTCTATGAAAAAACCC YKL070W GATCCCCGGGAATTGCCATGTCAGAAACGCTCCACTTTACTTCG YKLO58W GATCCCCGGGAATTGCCATGTTACTCGCTCTTTTTTGAGTTACATG YHR130C GATCCCCGGGAATTGCCATGCTAATTCCTGATGCCAAGTAACGA YIL070C GATCCCCGGGAATTGCCATGTTAGTGGAAAAACTTCTTCATCTTTTC YHR195W GATCCCCGGGAATTGCCATGTTAGTATCTAAATGGTTGAGAGTATG YIR022W GATCCCCGGGAATTGCCATGCTACTCGCCCCCCAGCAGAG YJL089W GATCCCCGGGAATTGCCATGTTAGAAGGTCGAGTTCAAAATATTCT YJL172W GATCCCCGGGAATTGCCATGTTAAGCGTATTCGTTAACATTAACGA YHR1 13W GATCCCCGGGAATTGCCATGTTAGACAACAATTTCAGATTCTATGG YHR175W GATCCCCGGGAATTGCCATGTTAATGGCAGGCGAGGGAGCTG YGR212W GATCCCCGGGAATTGCCATGCTAGTATAAATTTAAGTAATCTTTCATAT YJL024C GATCCCCGGGAATTGCCATGTTATTGCCCCGTTGCCCATTGTG YGR180c GATCCCCGGGAATTGCCATGTTAGAAGTCATCATCAAAGTTAATTTC YJL179W GATCCCCGGGAATTGCCATGTTAATTCTTCATCAATGCCTTTAGATT YJL001W GATCCCCGGGAATTGCCATGTTATAGTTGTTCATATTCATCAGGGT YJL208C GATCCCCGGGAATTGCCATGTCAATTCCTTTTTTTTGGAGGAGGT YJL152W GATCCCCGGGAATTGCCATGTCACGCAGACATGCGACTGCG YJL131C GATCCCCGGGAATTGCCATGTTACATTTCATTCATTTTTTTTCTCTGA YJL151C GATCCCCGGGAATTGCCATGCTAAGTACGGCCGGAAGAGAGC YLR441C GATCCCCGGGAATTGCCATGTTACACAGTTTCCAAGACTTCGTC YLR415C GATCCCCGGGAATTGCCATGCTACTTCCAAACAACTGGTCCAGA YLR212C GATCCCCGGGAATTGCCATGTTATACTAATTTATGATCACCGTCGG YLR029C GATCCCCGGGAATTGCCATGTTATTTTCTGTATCTCCACAAGGAC YLLO41C GATCCCCGGGAATTGCCATGCTAGGCAAATGCCAAAGATTTCTTA YLR105C GATCCCCGGGAATTGCCATGCTAGTCTCTATTTCTTCCGGGAAC YIL136W GATCCCCGGGAATTGCCATGCTAGTCCTTTTTCGAGCTCCAGAA YLR215C GATCCCCGGGAATTGCCATGCTAAGTTTCATTCTCACTATCACTG YLR321C GATCCCCGGGAATTGCCATGCTACATTCTCATTGTGGTTTCTAAG YMR260C GATCCCCGGGAATTGCCATGTTAATCATAAATAGTTTCATAAGTGTGT YNL120C GATCCCCGGGAATTGCCATGTCACTTCCTATGCAAAATGCTTAATA YLR407W GATCCCCGGGAATTGCCATGTCAGTCATGGCATGCCTTGGCA YMR197C GATCCCCGGGAATTGCCATGCTAAAATGAAGACAGCCACAATCTG YMR100W GATCCCCGGGAATTGCCATGCTATTGATTGTTTGTTCCACGGACT YMR21 OW GATCCCCGGGAATTGCCATGTTATGAAGTCCATGGTAAATTCGTG YMR318C GATCCCCGGGAATTGCCATGTTACATGAGGTTCATGTTCATGTTAG YMR069W GATCCCCGGGAATTGCCATGTTATTTTTTACTTAATTTCATCCATTTAG YNL076W GATCCCCGGGAATTGCCATGTTATGTATCACAACTATTAAATTCAGTT YNL024C GATCCCCGGGAATTGCCATGTTAATCTCTTTCAAAACAGACAGCAA YNL125C GATCCCCGGGAATTGCCATGCTATTTTTCACTTTGGCTGTTGCC YNL029C GATCCCCGGGAATTGCCATGTTAACTCTCTTGTCCCGATTTCTC YMR1 15W GATCCCCGGGAATTGCCATGTTAGTTTCTCAAGTGACTATTGTGAA YNL244C GATCCCCGGGAATTGCCATGTTACGAATCAGTCCGATTGGACTT YNL334C GATCCCCGGGAATTGCCATGTTAAGCTGGAAGAGCCAATCTCTT YNRO18W GATCCCCGGGAATTGCCATGTTATTTCAAAGTCTTCAACAATTTTTCT YNL277W GATCCCCGGGAATTGCCATGTTAGTCTTCATGCTTATCACAGAAC YOL1 18C GATCCCCGGGAATTGCCATGTCACTTCAAAGTCTCTGGAATATGA YOL123W GATCCCCGGGAATTGCCATGTTATTCGTCTTCTTCCAAAGTTTGAG YOR020C GATCCCCGGGAATTGCCATGCTATGAGCGATCCCGTTTTGTGAA YOL1 16W GATCCCCGGGAATTGCCATGTTAATAATTGAATTTAATTTTACTTCTGTT YOR305w GATCCCCGGGAATTGCCATGTCACCGACTCATTTTGTTAAGCTTG YPL267W GATCCCCGGGAATTGCCATGTTACTCATCTTCATAGACGTGGAAG YPL229w GATCCCCGGGAATTGCCATGCTAACATTTCTTATTATCTCTATATATC YPL038W GATCCCCGGGAATTGCCATGCTAACTGCTTTTTTCGTGTTGAGTA YPR047W GATCCCCGGGAATTGCCATGTCATTTTTGTCCCTTTATATCAATTTTT YPL011C GATCCCCGGGAATTGCCATGTTAGCGTTTTTTTTTGCCCTTCTTC YPR148C GATCCCCGGGAATTGCCATGCTAAATTTCCAAACCATTTAGAACTTT YOL103W GATCCCCGGGAATTGCCATGCTAAGACTTGAAATTAATTAATTCGGG YOR016C GATCCCCGGGAATTGCCATGTCACTGTATCTCGCTGTCACAATC YPLO79W GATCCCCGGGAATTGCCATGCTATTGTAATTCCCTTATAGTGTTCA YOR26OW GATCCCCGGGAATTGCCATGTTATTTAAGCTCGAAATGGCTATTGA YOR360C GATCCCCGGGAATTGCCATGTCATTGTGGAAGAGGTCTTCTAGG YDL060W GATCCCCGGGAATTGCCATGTTACATACCATTCCAAGGTAACGAA YDLO05C GATCCCCGGGAATTGCCATGCTATATATTGAAGCCGCTGAGGTC YPL210C GATCCCCGGGAATTGCCATGCTACTTACGTACTAAAATAGTCTCTT YMR1 18C GATCCCCGGGAATTGCCATGTTACTGAGCCAGTAAATACGTTCCT YPRO52C GATCCCCGGGAATTGCCATGCTAAGCCAAAGTGGCGTTATATAAC YLR224W GATCCCCGGGAATTGCCATGTCATCTTCGAAGATAAGGGGTATTC YLR275W GATCCCCGGGAATTGCCATGTTACTCAACAGGGGTTTTTAACACA YMR154C GATCCCCGGGAATTGCCATGTTATTTTGGTATCACATCATCGGAG YDR205w GATCCCCGGGAATTGCCATGTCAATTTGCTATAGGCTGTAGCGG YPR037C GATCCCCGGGAATTGCCATGTTAGAACTGAATTATTTCACATTGTCT YNRO08W GATCCCCGGGAATTGCCATGTTACATTGGGAAGGGCATCTGAGA YOR084W GATCCCCGGGAATTGCCATGTTACAGTTTTTGTTTAGTCGTTTTAAC YGRO54W GATCCCCGGGAATTGCCATGTTATTCATCCTTCCAACCCAACTTT YGL106W GATCCCCGGGAATTGCCATGTCATTGTCTCAAAACATCTTCGATG YAL067C GATCCCCGGGAATTGCCATGTTATTTTTCATCAGATACTGATAAGGT YILO23c GATCCCCGGGAATTGCCATGTCAATGCTCATCCATGAGCGCCA YBR064W GATCCCCGGGAATTGCCATGCTAAAATATGGAGGAACTAGGTTTAA bOO19 TTGCTCTTCGTTAAACTGATGGACGCAAACGAACG b2148 TTGCTCTTCGTTATTTCTTACGCGCGTATTTCAGTG b2796 TTGCTCTTCGTTAGCTGAACAGAGAGTAGAAGATT b2082 TTGCTCTTCGTTACATCCACATAATTTGCTGCCC b0124 TTGCTCTTCGTTACTTCACATCATCCGGCAGCG b3116 TTGCTCTTCGTTAAAACAGTTTGTATACGATGTTCAG b1830 TTGCTCTTCGTTACTTGACGGGAGCGGGTTGT b1453 TTGCTCTTCGTTAACTCGCCGTTTCAGGCTTAAA b2664 TTGCTCTTCGTTAATTGCCAGCCATCGCCTG b2799 TTGCTCTTCGTTACCAGGCGGTATGGTAAAGCT b3327 TTGCTCTTCGTTAATTAATCATTGAGTTAAGTTGAAGA b0970 TTGCTCTTCGTTAATCGCGGCTAGCGAAGCCC YER003C GATCCCCGGGAATTGCCATGCTAATTTGGTTCCACAAAGGCTCTA YCLO27W GATCCCCGGGAATTGCCATGTCAGTCGTATTCTTGGAGACAGTC YBR1 12C GATCCCCGGGAATTGCCATGTTAGTCGTCGTAGTTTTCATCTTCT YNL079C GATCCCCGGGAATTGCCATGTCACAAGTTTTCCAGAGATGCAGC YFRO42W GATCCCCGGGAATTGCCATGTCATTTTGTTAATAGTTTTTTGTATGCT YER137C GATCCCCGGGAATTGCCATGTTATTTCTTGGGTATAACTGTCAGTC YKL103C GATCCCCGGGAATTGCCATGTCACAACTCGCCGAATTCATCGTA YNL090W GATCCCCGGGAATTGCCATGTTATAAAATTATGCAACAGTTAGCCC YGR161C GATCCCCGGGAATTGCCATGCTATTTCAATGAACCAGTTTGGAATC YDR071 C GATCCCCGGGAATTGCCATGCTAGTTGTCGTATTCTTCCTTAATTA 0318.0.1 Vector preparation 0319.0.1 The preferred binary vector 1bxbigResgen for yeast and 1bxSuperCoLic for E.coli, which is based on the modified pPZP binary vector backbone (comprising 5 the kanamycin-gene for bacterial selection; Hajukiewicz, P. et al., 1994, Plant Mol. Biol., 25: 989-994) carried the selection marker bar-gene (De Block et al., 1987, EMBO J. 6, 2513-2518) driven by the masl'promotor (Velten et al., 1984, EMBO J. 3, 2723 2730; Mengiste, Amedeo and Paszkowski, 1997, Plant J., 12, 945-948) on its T-DNA. In addition the T-DNA contained the strong double 35S(Kay et al., 1987, Science 236, 10 1299-1302) for yeast or Super promotor (Ni et al., 1995, Plant Journal 7, 661-676) for E.coli in front of a cloning cassette followed by the nos-terminator (Depicker A. Stachel S. Dhaese P. Zambryski P. Goodman HM. Nopaline synthase: transcript mapping and DNA sequence. Journal of Molecular & Applied Genetics. 1(6):561-73, 1982.). The cloning cassette consists of the following sequence: 15 0320.0.1 'Yeast: 5'-GGAATTCCAGCTGACCACCATGGCAATTCCCGGGGATC 3 or 0321.0.1 E.coli: 5'-TTG CTC TTC CAT GGC AAT GAT TAA TTA ACG AAG AGC AA-3', respectively. 0322.0.1 Other selection marker systems, like the AHAS marker or other 20 promotors, e.g. superpromotor (see above), 35S promotor (see above) , Ubiquitin promotor (Callis et al., J. Biol. Chem., 1990, 265: 12486-12493; US 5,510,474; US 6,020,190; Kawalleck et al., Plant. Molecular Biology, 1993, 21: 673-684) or 34S promotor (GenBank Accession numbers M59930 and X16673) were similar useful for the instant invention and are known to a person skilled in the art. The vector was 25 linearised with EcoR and Smal for yeast or Smal and Sac for E.coli using the standard protocol provided by the supplier (MBI Fermentas, Germany) and purified using Qiagen columns (Qiagen, Hilden, Germany). 0323.0.1 Ligation and transformation 0324.0.1 Present ORF fragments (- 100 ng) were digested by EcoRI and Smal 30 for yeast and Smal and Sac for E.coli using the standard protocol provided by the supplier (MBI Fermentas, Germany), purified using Qiagen columns (Qiagen, Hilden, Germany) and were ligated into the cloning cassette of the binary vector systems (- 30 ng) using standard procedures (Maniatis et al.). 0325.0.1 In the case of internal EcoRI, Smal and Sac restriction sites a blunt end 35 cloning procedure was applied. The undigested ORF fragments were directly purified and ligated into the cloning cassette of the binary vector. In this case the EcoRI site was refilled by Klenow reaction and the Sacl site blunted Pfu DNA polymerase. 0326.0.1 Ligation products were transformed into E.coli (DH5alpha) using a standard heat shock protocol (Maniatis et al.). Transformed colonies were grown on LB 5 media and selected by respective antibiotica (Km) for 16h at 37 'C. Positive clones were identified by control PCR reactions using a combination of a vector specific and the respective ORF specific primers. 0327.0.1 Plasmidpreparation 0328.0.1 Plasmid DNA was prepared from positive clones using standard 10 protocols (Qiagen Hilden, Germany). 0329.0.1 Transformation of Agrobacteria 0330.0.1 Plasmids were transformed into Agrobacterium tumefaciens (GV3101pMP90; Koncz and Schell, 1986, Mol. Gen. Genet. 204: 383-396) using heat 15 shock or electroporation protocols. Transformed colonies were grown on YEP media and selected by respective antibiotics (Rif/Gent/Km) for 2d at 28 'C. These Agrobacterium cultures were used for the plant transformation. 0331.0.1 Arabidopsis thaliana was grown and transformed according to standard conditions Bechtold 1993 (Bechtold, N., Ellis, J., Pelletier, G. 1993. In planta 20 Agrobacterium mediated gene transfer by infiltration of Arabidopsis thaliana plantsC.R. Acad.Sci.Paris. 316:1194-1199); Bent et al. 1994 (Bent, A., Kunkel, B.N., Dahlbeck, D., Brown, K.L., Schmidt, R., Giraudat, J., Leung, J., and Staskawicz, B.J. 1994; PPCS2 of Arabidopsis thaliana: A leucin-rich repeat class of plant disease resistant genes; Science 265: 1856-1860). 25 0332.0.1 Transgenic A. thaliana plants were grown individually in pots containing a 4:1 (v/v) mixture of soil and quartz sand in a York growth chamber. Standard growth conditions were: photoperiod of 16 h light and 8 h dark, 20 'C, 60% relative humidity, and a photon flux density of 150 pE. To induce germination, sown seeds were kept at 4 0C, in the dark, for 3 days. Plants were watered daily until they were approximately 3 30 weeks old at which time drought was imposed by withholding water. Parallely, the relative humidity was reduced in 10% increments every second day to 20%. After approximately 12 days of withholding water, most plants showed visual symptoms of injury, such as wilting and leaf browning, whereas tolerant plants were identified as being visually turgid and healthy green in color. Plants were scored for symptoms of 35 drought injury in comparison to neighbouring plants for 3 days in succession. 0333.0.1 Three successive experiments were conducted. In the first experiment, 10 independent T2 lines were sown for each gene being tested. The percentage of plants not showing visual symptoms of injury was determined. In the second experiment, the lines that had been scored as tolerant in the first experiment were put through a confirmation screen according to the same experimental procedures. In this experiment, plants of each tolerant line were grown and treated as before. In the third 5 experiment, at least 7 replicates of the most tolerant line were grown and treated as before. The average and maximum number of days of drought survival after wild-type control had visually died were determined. Additionally measurements of chlorophyll fluorescence were made in stressed and non-stressed plants using a Mini-PAM (Heinz Walz GmbH, Effeltrich, Germany). 10 0334.0.1 In the first experiment, after 12 days of drought, the control, non transgenic Arabidopsis thaliana and most transgenic lines expressing other transgenes in the test showed extreme visual symptoms of stress including necrosis and cell death. Several plants expressing the genes retained viability as shown by their turgid appearance and maintenance of green color. 15 0335.0.1 The second experiment compared a smaller number of independent transgenic lines for each gene but a greater number of progeny within each independent transformation event. This experiment confirmed the previous results. Those lines containing the specific SRP encoding yeast genes survived longer than the controls. In some cases the transgenic line survived more than 3 days after the controls 20 had died. 0336.0.1 According to the results of the first and second experiments some major lines containing the specific SRP encoding yeast genes were identified, which showed the best results with regard to the average days of survival after wild type and/or the hit percentage. 25 0337.0.1 In a third experiment these major lines were tested with multiple replicates (4-80 plants per line). The average number of days the plants of the major line survived longer than wild-type was measured. I.e., the number '1' means that, on average, the plants overexpressing this ORF, on averaged survived 1 day longer than wild-type. The value for WT in this column is '0'. The results are summmarised in table 30 3. 0338.0.1 Table 3: Drought tolerance of transgenic Arabidopsis thaliana expressing the various SRP encoding genes from Saccharomyces cerevisiae or E. coli after imposition of drought stress on 3 week old plants in a third experiment using several plants from one transgenic line (experiment 3). Drought tolerance is measured 35 for the indicated number of transgenic plants (Plants tested) as the average number of days (Average days of survival after WT) that the transgenic plants survived after the control (untransformed wild type). The hit percentage indicates the fraction of the tested plants of the major line that was actually resistant, i.e. the number '50' indicates that half of the tested plants were resistant (survived longer than WT). For WT, this column has the value '0'. Sequ. ID Gene Plants Average days of survival No. tested after WT 1 YGL263W 12 1,17 3 YGR004W 11 1,36 5 YGR014W 11 0,82 7 YGL239C 13 2,4 9 YBL060W 14 1,6 11 YGL166W 14 1,07 13 YDL202W 15 0,47 15 YAL046C 14 1,9 17 YDR101C 14 3,57 19 YDR108W 14 0,5 21 YAL064W 33 2,29 23 YDR134C 13 0,8 26 YFLO31w 13 1,3 28 YFL052W 14 1,1 30 YFLO42C 11 1,3 32 YBR025C 11 1,4 34 YER174C 22 1,05 36 YBR051W 10 1,2 38 YER175C 11 1,7 40 YDR521W 14 0,5 42 YER167W 35 0,66 44 YER123W 11 2,2 46 YDR415C 7 2,71 48 YELO52W 4 1,5 50 YDR536W 14 1,5 52 YDR513W 7 3,14 54 YELO45C 14 1,64 56 YELO41W 13 1,77 58 YDR415C 7 2,71 60 YDL238C 35 1,2 62 YBR282W 14 1,79 64 YBR258C 9 3,4 66 YCL001W-A 36 1,78 68 YBR274W 14 2 70 YHR090C 8 4,5 72 YGR121C 40 1,6 74 YGR127W 8 1,4 76 YGR150C 12 2,6 78 YKL037W 14 0,79 80 YKL051W 16 2,4 82 YKL120W 14 0,64 84 YKLO11C 12 1,9 86 YKL017C 10 1,8 88 YKL049C 80 1,92 90 YKL132C 33 1,82 92 YGR126W 8 2,3 94 YKL070W 14 2,1 96 YKL058W 9 1,44 98 YHR130C 9 1,8 100 YIL070C 13 0,69 102 YHR195W 14 1,9 104 YlR022W 14 1,07 106 YJL089W 14 0,86 108 YJL172W 11 0,82 110 YHR113W 15 2 112 YHR175W 9 0,78 114 YJL024C 13 0,69 116 YGR180c 14 2,9 118 YJL179W 18 1,3 120 YJL001W 14 1,6 122 YJL208C 12 1,4 124 YJL152W 13 1,3 126 YJL131C 14 0,6 128 YJL151C 14 1,9 130 YLR441C 10 2 132 YLR415C 14 1,6 134 YLR212C 13 0,64 136 YLR029C 14 1,56 137 YLLO41C 13 0,92 139 YLR105C 14 0,86 141 YIL136W 8 2,25 143 YLR215C 13 1,77 145 YLR321C 14 1,29 147 YMR260C 11 2,09 149 YNL120C 7 2 151 YLR407W 12 1,17 153 YMR197C 14 0,57 155 YMR100W 12 1,25 157 YMR21OW 10 1,1 159 YMR318C 13 0,85 161 YMR069W 8 1,25 163 YNL076W 13 1,31 165 YNL024C 13 1,08 167 YNL125C 4 1,75 169 YNL029C 13 1,92 171 YMR115W 12 0,75 173 YNL244C 11 1,55 175 YNL334C 14 1,5 177 YNR018W 14 1,29 179 YNL277W 14 1,14 181 YOL118C 14 1,71 183 YOL123W 14 0,71 185 YOR020C 12 1,83 187 YOL116W 13 1,08 189 YOR305w 15 1,2 191 YPL267W 6 2,5 193 YPL229w 5 2 195 YPLO38W 10 1,3 197 YPR047W 11 1 199 YPLO11C 12 0,75 201 YPR148C 10 1,1 203 YOL103W 12 0,75 205 YORO16C 14 0,79 207 YPLO79W 15 1,33 209 YOR26OW 7 1,29 211 YOR360C 15 1,53 213 YDL060W 15 0,67 215 YDLO05C 15 1 217 YPL210C 15 1,13 219 YMR118C 14 1,14 221 YPR052C 14 1,07 223 YLR224W 10 2,1 225 YLR275W 9 2,44 227 YMR154C 15 1,27 229 YDR205w 12 1,08 231 YPR037C 12 2,17 233 YNRO08W 14 2,29 235 YOR084W 10 2,2 237 YGR054W 14 1,5 239 YGL106W 13 3,46 241 YAL067C 13 1,62 243 YIL023c 15 1,73 245 YBR064W 15 1,13 247 b0020 13 0,78 249 b2148 15 3,13 251 b2796 15 2,33 253 b2082 14 2,43 255 b0124 15 2,87 257 b3116 15 1,07 259 b1830 15 2,07 261 b1453 14 2,29 263 b2664 13 1,85 265 b2799 15 1,87 267 b3327 15 1,47 269 b0970 15 1,33 271 YER003C 5 1 273 YCL027W 9 0.56 275 YBR112C 10 0.5 277 YNL079C 9 0.67 279 YFR042W 9 0.78 281 YER137C 3 0 283 YKL103C 9 1 285 YNL090W 6 0.83 287 YGR161C 7 0.86 289 YDR071C 9 0.78 0339.0.1 In a further experiment, for individual major lines, other lines containing the same gene contruct, but resulting from a different transformation event were tested. In these lines, the specific SRP encoding yeast genes is incorporated at a different site 5 in the plant genom. The results are summmarised in table 4 in accordance to table 3. The resuls demonstrate the dependence of the stress tolerance and/or resistance in plants on the expression of the SRP, rather than the insertion event. 0340.0.1 Table 4: Drought tolerance of transgenic Arabidopsis thaliana expressing selected SRP encoding genes from Saccharomyces cerevisiae or E. coli 10 after imposition of drought stress on 3 week old plants in a third experiment using one plant from severalindependent transgenic lines each (experiment 3). Drought tolerance is measured for the indicated number of transgenic plants (Plants tested) as the average number of days (Average days of survival after WT) that the transgenic plants survived after the control (untransformed wild type). The hit percentage indicates the fraction of the tested plants of the major line that was actually resistant, i.e. the number 5 '50' indicates that half of the tested plants were resistant (survived longer than WT). For WT, this column has the value '0'. Sequ. Number Sequ. umberAverage days of ID No. Gene other lines survival after WT tested 1 YGL263W 7 1,43 3 YGR004W 8 1 5 YGR014W 8 0,75 7 YGL239C 5 1 9 YBL060W 8 2 11 YGL166W 8 0,63 13 YDL202W 8 0,25 15 YAL046C 7 1,3 17 YDR101C 9 1,1 19 YDR108W 9 0,22 21 YAL064W 8 3 23 YDR134C 6 2,2 26 YFL031w 9 2,3 28 YFL052W 5 1,4 32 YBR025C 5 1,2 34 YER1 74C 9 0,5 36 YBR051W 6 1,3 38 YER175C 4 1,4 40 YDR521W 3 0,7 44 YER123W 6 0,3 46 YDR415C 7 1,4 48 YELO52W 3 1,33 50 YDR536W 8 1,25 52 YDR513W 4 1,5 54 YELO45C 5 1,2 56 YELO41W 8 0,88 60 YDL238C 6 0,17 62 YBR282W 9 2,2 64 YBR258C 7 1,7 66 YCL001W-A 7 0,57 68 YBR274W 9 0,78 70 YHR090C 6 2,7 72 YGR121C 9 0,8 74 YGR127W 6 2,5 76 YGR150C 5 3 78 YKL037W 9 0,78 80 YKL051W 5 1,8 82 YKL120W 8 0,63 84 YKL011C 5 1,4 86 YKL017C 5 0,6 88 YKL049C 9 1,4 90 YKL132C 7 0,7 92 YGR126W 6 1,3 94 YKL070W 6 2 96 YKL058W 8 0,88 98 YHR130C 9 2,1 100 YIL070C 7 0,71 102 YHR195W 9 2,1 104 YIR022W 9 1,22 106 YJL089W 7 0,6 108 YJL172W 4 1 110 YHR113W 7 1,6 112 YHR175W 3 1 114 YJL024C 6 1,33 116 YGR180c 8 2,7 118 YJL179W 8 1,8 120 YJL001W 9 0,7 122 YJL208C 6 1,7 124 YJL152W 8 0,3 126 YJL131C 6 1 128 YJL151C 8 1,6 130 YLR441C 7 2,6 132 YLR415C 9 0,3 134 YLR212C 7 2,14 136 YLR029C 8 0,25 137 YLLO41C 7 0,86 139 YLR105C 7 0,29 141 YIL136W 9 1,75 143 YLR215C 8 1,25 145 YLR321C 7 0,86 147 YMR260C 8 0,88 149 YNL120C 9 1,56 151 YLR407W 5 0,4 153 YMR197C 9 1,22 155 YMR100W 8 0,88 157 YMR210W 8 0,88 159 YMR318C 8 0,63 161 YMR069W 9 0,44 163 YNL076W 4 1,75 165 YNL024C 9 1,78 167 YNL125C 7 2,14 169 YNL029C 9 1,88 171 YMR115W 9 1,44 173 YNL244C 8 0,25 175 YNL334C 9 1,33 177 YNRO18W 9 1,22 179 YNL277W 8 1 181 YOL118C 9 0,89 183 YOL123W 8 0,88 185 YOR020C 9 0,44 187 YOL116W 9 1,67 189 YOR305w 7 0,28 191 YPL267W 4 0,75 193 YPL229w 5 1,6 195 YPLO38W 5 0,4 197 YPR047W 2 1 199 YPLO11C 6 0,5 201 YPR148C 9 0,33 203 YOL103W 9 0,33 205 YORO16C 9 0,56 211 YOR360C 8 0,38 213 YDL060W 8 0,5 215 YDLO05C 9 0,44 217 YPL210C 8 1,5 219 YMR118C 10 1,1 221 YPR052C 7 0,86 223 YLR224W 9 1,22 225 YLR275W 8 1,75 227 YMR154C 9 1,11 229 YDR205w 4 1 231 YPR037C 5 3,4 233 YNRO08W 8 0,75 235 YOR084W 6 0,5 239 YGL106W 7 2,14 241 YAL067C 6 1,83 243 YIL023c 1 3 245 YBR064W 7 0,71 247 b0020 4 1,5 249 b2148 10 0,1 251 b2796 11 0,72 253 b2082 9 1,22 255 b0124 9 3,3 257 b3116 8 1 259 b1830 7 1,71 261 b1453 8 1,13 263 b2664 9 1 267 b3327 10 0,8 269 b0970 8 1,5 271 YER003C 12 2,08 273 YCLO27W 14 2,14 275 YBR112C 11 3,3 277 YNL079C 13 2,69 279 YFRO42W 7 2,3 281 YER137C 13 2,2 283 YKL103C 10 2,8 285 YNL090W 12 4,33 287 YGR161C 12 2,7 289 YDR071C 11 3 0341.0.1 Chlorophyll fluorescence measurements of photosynthetic yield confirmed that severe drought stress completely inhibited photosynthesis in the control 5 plants, but the transgenic major lines maintained photosynthetic function longer (Table 5). 0342.0.1 Table 5: Drought tolerance of transgenic Arabidopsis thaliana expressing the various SRP encoding genes from Saccharomyces cerevisiae or E. coli after imposition of drought stress on 3 week old plants in a third experiment using 10 several plants from one transgenic line (experiment 3). Drought tolerance is reported as photosynthetic yield measured by chlorophyll fluorescence measured at three different time point during the drought stress experiment, and compared to the untransformed wild type control. For each transgenic line, the average of 5 replicate plants is indicated, the wild type value is the average of 20-25 plants measured in the 15 same experiment. A r%-7 Photosynthetic Photosynthetic Photosynthetic Sequ. yield 6 days wild yield 10 wild yield 14 days wild ID No. Gene after final type days after type after final type watering watering watering 1 YGL263W 751 766 765 654 264 106 3 YGRO04W 759 766 755 654 246 106 5 YGRO14W 759 766 752 654 7 YGL239C 782 757 786 610 9 YBL060W 743 757 782 610 108 16 11 YGL166W 752 736 747 709 13 YDL202W 790 766 508 548 15 YALO46C 788 760 756 549 216 20 19 YDR108W 756 736 739 709 0 20 23 YDR1 34C 757 760 765 549 273 20 26 YFLO31w 763 760 766 549 784 20 28 YFL052W 757 757 753 610 30 YFL042C 743 757 780 610 32 YBR025C 763 760 762 549 631 20 36 YBR051W 741 760 696 549 456 20 38 YER175C 749 757 627 610 140 16 44 YER123W 767 757 780 610 147 16 48 YEL052W 750 736 773 710 177 20 50 YDR536W 753 736 772 709 293 20 52 YDR513W 782 794 660 413 411 54 54 YEL045C 755 736 553 709 147 20 56 YEL041W 758 736 769 709 129 20 62 YBR282W 759 760 724 549 221 20 64 YBR258C 759 757 772 610 144 16 68 YBR274W 749 736 769 709 146 20 70 YHR090C 749 760 765 549 620 20 74 YGR127W 740 549 576 20 76 YGR150C 771 760 742 549 618 20 78 YKLO37W 761 736 760 709 134 20 80 YKL051W 733 760 740 549 153 20 82 YKL120W 759 736 518 709 84 YKLO11C 750 760 694 549 434 20 86 YKLO17C 744 549 734 549 754 20 92 YGR126W 784 760 750 549 159 20 94 YKL070W 774 760 734 549 244 20 96 YKL058W 752 766 765 654 495 20 98 YHR130C 772 760 756 549 147 20 100 YILO70C 768 766 755 654 102 YHR195W 753 757 693 610 141 16 104 YlR022W 761 736 771 709 108 YJL172W 756 766 758 654 293 20 110 YHR113W 749 760 754 549 142 20 112 YHR175W 768 766 758 654 465 106 114 YJL024C 762 766 758 654 736 106 116 YGR180c 763 757 779 610 118 YJL179W 744 760 606 549 310 20 120 YJL001W 748 757 519 610 135 16 122 YJL208C 685 549 49 20 124 YJL152W 754 757 726 610 126 YJL131C 750 757 758 610 128 YJL151C 755 760 764 549 152 20 130 YLR441C 745 760 762 549 277 20 132 YLR415C 739 757 503 610 144 16 134 YLR212C 740 736 759 709 103 20 136 YLR029C 746 736 780 709 292 20 139 YLR105C 751 736 764 709 141 YIL136W 749 736 779 710 422 20 143 YLR215C 752 736 774 709 151 20 145 YLR321C 749 736 767 709 145 20 147 YMR260C 774 766 763 654 691 106 149 YNL120C 764 766 740 654 298 20 151 YLR407W 774 766 640 654 138 106 153 YMR197C 751 736 723 709 63 20 155 YMR100W 770 766 596 654 171 20 157 YMR21OW 753 766 755 654 733 20 159 YMR318C 761 736 780 709 135 20 161 YMR069W 756 766 750 654 519 20 163 YNL076W 765 766 757 654 244 20 165 YNL024C 767 766 761 654 279 20 167 YNL125C 761 766 750 654 283 20 169 YNL029C 764 766 758 654 171 YMR115W 755 736 739 709 173 YNL244C 774 766 696 654 94 20 175 YNL334C 751 736 756 709 177 YNRO18W 756 736 749 709 181 YOL118C 727 736 756 709 280 20 183 YOL123W 747 736 140 20 185 YOR020C 764 766 748 654 207 20 187 YOL116W 774 766 735 654 135 20 189 YOR305w 773 769 565 245 191 YPL267W 757 767 756 548 193 YPL229w 781 769 752 245 197 YPR047W 761 769 597 245 199 YPLO11C 766 769 582 245 201 YPR148C 771 769 401 245 203 YOL103W 789 769 237 245 205 YOR016C 770 769 523 245 211 YOR360C 771 769 651 245 215 YDL005C 782 769 702 245 217 YPL210C 794 769 735 245 219 YMR118C 777 768 499 272 221 YPR052C 772 768 298 272 223 YLR224W 767 768 434 272 225 YLR275W 741 768 780 272 227 YMR154C 760 768 734 272 229 YDR205w 787 768 241 272 231 YPR037C 759 768 740 272 233 YNR008W 746 768 782 272 235 YOR084W 758 768 765 272 237 YGR054W 766 768 140 272 239 YGL106W 760 768 477 272 241 YAL067C 759 768 681 272 243 YILO23c 769 814 245 YBR064W 745 750 770 576 117 31 249 b2148 736 768 740 272 251 b2796 761 768 319 272 253 b2082 756 768 706 272 255 b0124 756 768 571 272 257 b3116 765 768 600 272 259 b1830 757 768 772 272 261 b1453 750 768 648 272 263 b2664 764 768 521 272 265 b2799 763 768 615 272 267 b3327 766 768 499 272 269 b0970 764 768 560 272 271 YER003C 758 760 769 549 729 20 273 YCLO27W 749 760 770 549 145 20 275 YBR112C 760 760 760 549 731 20 277 YNL079C 763 766 762 654 216 20 279 YFRO42W 789 760 739 549 232 20 281 YER137C 760 760 728 549 458 20 283 YKL103C 747 760 763 549 791 20 285 YNL090W 757 760 783 549 403 20 287 YGR161C 742 760 753 549 225 20 289 YDR071C 737 757 793 610 707 16 0343.0.4 Metabolic analysis of transgenic plants The described metabolic changes in transgenic plants were identified using the following experimental procedure: 5 0344.0.4 a) Growth and treatment of plants 0345.0.4 Plants were grown in climate chambers under standard conditions on pot soil for three weeks (see above). Eight days prior to harvest, water was withheld for part of the plants (8-day treatment). Four days prior to harvest, water was withheld for another group of plants (4-day treatment). The plants of "control treatment" were 10 normally watered throughout the growth period. Plants due to be analysed in the same analytical sequence were grown side-by-side to avoid environmental influences. 0346.0.4 b) Sampling and storage of samples 03470.4 Sampling took place in the climate chamber. Green parts were cut with a pair of scissors, quickly weighed, and immediately put into a liquid nitrogen pre-cooled 15 extraction thimble. Racks with extraction thimbles were stored at -80'C until extraction. 0348.0.4 c) Freeze-drying Plants were not allowed to thaw or reach temperatures > -40'C until either the first contact with solvents or the removal of water by freeze-drying. 0349.0.4 The sample rack with extraction thimbles was put into the pre-cooled ( 20 40'C) freeze-dryer. The starting temperature for the main drying phase was -35'C, pressure was 0.120 mbar. For the drying process, parameters were changed according to a pressure and temperature program. The final temperature (after 12 hours) was +30'C, pressure was 0.001 - 0.004 mbar. After shutting down the vacuum pump and cooling machine, the system was aired with dried air or Argon. 25 0350.0.4 d) Extraction 0351.0.4 Extraction thimbles with plant material were transferred to 5 mL extraction cells on the ASE (Accelerated Solvent Extractor ASE 200 with Solvent Controller and AutoASE-Software (DION EX)) immediately after freeze-drying. 0352.0.4 Polar substances were extracted with approximately 10 mL 30 Methanol/Water (80/20, v/v) at T = 70 'C und p = 140 bar, 5 min heating phase, 1 min static Extraction. Lipid substances were extracted with approximately 10 mL Methanol/Dichlormethan (40/60, v/v) at T = 70 'C und p = 140 bar, 5 min heating phase, 1 min static Extraction. Both extracts were collected in one extraction vial (Centrifuge tubes, 50 mL with screw-on lid and Septum for ASE (DIONEX)).

0353.0.4 The following internal standards were added to the extracts: LC Standards L-Methionine-d3, Boc-Ala-Gly-Gly-Gly-OH, L-Tryptophan-d5, Arginine 3 C615N 4 , CoEnzyme Q1,2,4 and ribitol, L-glycine-2,2-d2. L-alanine-2,3,3,3-d4, alpha-methyl-glucopyranoside, nonadecanoic acid methyl ester, undecanoic acid 5 methyl ester, tridecanoic acid, pentadecanoic acid, nonacosanoic acid. To the resulting mixture, 8 mL water were added. The solid residues of plant and extraction thimble were discarded. 0354.0.4 The extract was centrifuged at 1400 g for 5-10 minutes to speed-up phase-separation. For GC and LC analysis, 1 mL each was taken from the colourless 10 methanol/water upper (polar) phase. The remaining upper phase was discarded. Of the dark-green, organic bottom phase 0.5 mL was taken for GC and LC analysis, respectively. All sample aliquots were evaporated using a IR-Dancer Infrared vacuum evaporator (Hettich), using a temperature maximum of 400C and a maximum pressure of 10 mbar. 15 0355.0.4 e) LC/MS- and LC/MS/MS-Analysis HPLC mobile phase was added to the lipid and polar residues, respectively (volume adjusted to the weighted sample) and an HPLC analysis using gradient elution was performed. 0356.0.4 f) Derivatisation of the lipid phase for GC/MS-Analysis 20 0357.0.4 For transmethanolysis, a mixture of 140 pl chloroform, 38 pL HCI (37% HCI in water), 320 pl methanol and 20 pl toluol was added to the residue. The sample container was carefully closed and reaction was carried out at 1000C for 2 hours. Subsequently, the solution was evaporated and the pellet was dried completely. 0358.0.4 The methoximation of carbonyl groups was achieved by a reaction with 25 100 pL methoxyamine-hydrochloride (5 mg/mL in Pyridine) for 1.5 hours at 600C, in a closed vial. 20 pL of a mixture of linear, odd-numbered fatty acids was added to provide a time standard. Finally, derivatisation with 100 pL N-Methyl-N-(trimethylsilyl) 2,2,2-trifluoracetamide (MSTFA) took place in a closed vial for 30 minutes at 600C. The final volume for GC injection was 220 pl. 30 0359.0.4 g) Derivatisation of the polar phase for GC/MS-Analysis 0360.0.4 The methoximation of carbonyl groups was achieved by a reaction with 50 pL methoxyamine-hydrochloride (5 mg/mL in Pyridine) for 1.5 hours at 600C, in a closed vial. 10 pL of a mixture of linear, odd-numbered fatty acids was added to provide a time standard. Finally, derivatisation with 50 pL N-methyl-N-(trimethylsilyl) 35 2,2,2-trifluoracetamide (MSTFA) took place in a closed vial for 30 minutes at 600C. The final volume for GC injection was 110 pl. 0361.0.4 h) Analysis of different plant samples 0362.0.4 Samples were measured in sequences of 20. Each sequence contained 5 wild type and 5 transgenic plants grown under control conditions, as well as 5 wild type and 5 transgenic plants from either the 4 day or 8 day drought treatment. 0363.0.4 The peak height or peak area of each analyte (metabolite) was divided 5 through the peak area of the respective internal standards. Data was normalised using the individual sample fresh weight. The resulting values were divided by the mean values found for wild type plants grown under control conditions and analysed in the same sequence, resulting in the so-called X-folds or ratios (see table 7 - 14), which represent values independent of the analytical sequence. These ratios indicate the 10 behavior of the metabolite concentration of the target plants in comparison to the concentration in the wild type control plants. 0364.0.4 In table 6 the results of the metabolite screening for the plants transformed in genes YCLO27W, YBR112C, YNL079C, YER137C, YKL103C, YNL090W, YGR161C, YDR071C are shown. 15 0365.0.4 Tables 6: Details on screening of metabolic activity. wild type YDR071C metabolite control 4 days 8 days control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 2-hydroxy-palmitic acid 1,00 1,11 1,25 1,18 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 alanine 1,00 0,64 0,64 alpha linolenic acid (c18:3 (c9, c12, c15)) 1,00 1,24 1,40 alpha-tocopherol 1,00 1,05 1,14 aminoadipic acid 1,00 1,73 1,65 anhydroglucose 1,00 1,02 1,16 arginine 1,00 0,39 0,33 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 beta-sitosterol 1,00 1,39 1,51 beta-tocopherol 1,00 0,54 0,60 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid (c16:2 me) 1,00 1,01 1,04 hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 cerotic acid (c26:0) 1,00 0,74 1,00 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 galactose 1,00 1,29 1,42 0,98 g-aminobutyric acid 1,00 1,16 1,32 gamma-tocopherol 1,00 0,54 0,60 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 isoleucine 1,00 1,28 1,66 iso-maltose 1,00 2,63 3,02 isopentenyl pyrophosphate 1,00 1,80 2,62 leucine 1,00 1,34 1,74 lignoceric acid (c24:0) 1,00 0,91 1,02 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 malate 1,00 2,91 3,46 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 ornithine palmitic acid (c16:0) 1,00 1,16 1,38 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 proline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 sinapine acid 1,00 2,74 3,44 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 zeaxanthine 1,00 1,27 1,34 wild type YER137C metabolite Control 4 days 8 days Control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 2,15 5,57 2-hydroxy-palmitic acid 1,00 1,11 1,25 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 1,55 1,73 alanine 1,00 0,64 0,64 1,32 0,94 alpha linolenic acid (c18:3 (c9, c12, c15)) 1,00 1,24 1,40 alpha-tocopherol 1,00 1,05 1,14 aminoadipic acid 1,00 1,73 1,65 anhydroglucose 1,00 1,02 1,16 1,26 0,63 arginine 1,00 0,39 0,33 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 beta-sitosterol 1,00 1,39 1,51 0,88 1,17 1,35 beta-tocopherol 1,00 0,54 0,60 2,78 5,83 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid (c16:2 me) 1,00 1,01 1,04 hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 1,10 1,28 cerotic acid (c26:0) 1,00 0,74 1,00 3,24 1,78 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 galactose 1,00 1,29 1,42 g-aminobutyric acid 1,00 1,16 1,32 4,44 10,51 gamma-tocopherol 1,00 0,54 0,60 2,78 5,83 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 1,17 2,32 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 1,12 1,57 2,05 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 isoleucine 1,00 1,28 1,66 iso-maltose 1,00 2,63 3,02 isopentenyl pyrophosphate 1,00 1,80 2,62 leucine 1,00 1,34 1,74 lignoceric acid (c24:0) 1,00 0,91 1,02 2,01 1,74 2,03 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 malate 1,00 2,91 3,46 1,67 5,70 6,01 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 ornithine palmitic acid (c16:0) 1,00 1,16 1,38 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 proline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 1,40 1,50 sinapine acid 1,00 2,74 3,44 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 zeaxanthine 1,00 1,27 1,34 wild type YBR112C metabolite Control 4 days 8 days Control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 0,63 2-hydroxy-palmitic acid 1,00 1,11 1,25 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 alanine 1,00 0,64 0,64 alpha linolenic acid (c18:3 (c9, c12, c15)) 1,00 1,24 1,40 1,12 1,42 alpha-tocopherol 1,00 1,05 1,14 aminoadipic acid 1,00 1,73 1,65 3,90 12,95 anhydroglucose 1,00 1,02 1,16 arginine 1,00 0,39 0,33 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 1,35 beta-sitosterol 1,00 1,39 1,51 1,19 beta-tocopherol 1,00 0,54 0,60 0,70 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid (c16:2 me) 1,00 1,01 1,04 hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 1,42 cerotic acid (c26:0) 1,00 0,74 1,00 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 1,20 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 galactose 1,00 1,29 1,42 g-aminobutyric acid 1,00 1,16 1,32 gamma-tocopherol 1,00 0,54 0,60 0,70 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 isoleucine 1,00 1,28 1,66 iso-maltose 1,00 2,63 3,02 isopentenyl pyrophosphate 1,00 1,80 2,62 leucine 1,00 1,34 1,74 lignoceric acid (c24:0) 1,00 0,91 1,02 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 1,17 malate 1,00 2,91 3,46 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 ornithine palmitic acid (c16:0) 1,00 1,16 1,38 1,11 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 proline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 sinapine acid 1,00 2,74 3,44 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 zeaxanthine 1,00 1,27 1,34 wild type YGR161C metabolite Control 4 days 8 days Control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 2-hydroxy-palmitic acid 1,00 1,11 1,25 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 alanine 1,00 0,64 0,64 alpha linolenic acid (c18:3 (c9, c12, c15)) 1,00 1,24 1,40 alpha-tocopherol 1,00 1,05 1,14 aminoadipic acid 1,00 1,73 1,65 anhydroglucose 1,00 1,02 1,16 arginine 1,00 0,39 0,33 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 beta-sitosterol 1,00 1,39 1,51 beta-tocopherol 1,00 0,54 0,60 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid (c16:2 me) 1,00 1,01 1,04 1,14 hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 1,22 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 cerotic acid (c26:0) 1,00 0,74 1,00 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 galactose 1,00 1,29 1,42 1,15 g-aminobutyric acid 1,00 1,16 1,32 gamma-tocopherol 1,00 0,54 0,60 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 isoleucine 1,00 1,28 1,66 iso-maltose 1,00 2,63 3,02 isopentenyl pyrophosphate 1,00 1,80 2,62 leucine 1,00 1,34 1,74 lignoceric acid (c24:0) 1,00 0,91 1,02 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 malate 1,00 2,91 3,46 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 1,18 ornithine palmitic acid (c16:0) 1,00 1,16 1,38 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 proline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 sinapine acid 1,00 2,74 3,44 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 zeaxanthine 1,00 1,27 1,34 YKL1 03C metabolite Control 4 days 8 days Control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 2-hydroxy-palmitic acid 1,00 1,11 1,25 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 alanine 1,00 0,64 0,64 alpha linolenic acid (c18:3 (c9, c12, c15)) 1,00 1,24 1,40 alpha-tocopherol 1,00 1,05 1,14 aminoadipic acid 1,00 1,73 1,65 anhydroglucose 1,00 1,02 1,16 arginine 1,00 0,39 0,33 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 beta-sitosterol 1,00 1,39 1,51 beta-tocopherol 1,00 0,54 0,60 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid (c16:2 me) 1,00 1,01 1,04 1,18 1,16 1,30 hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 cerotic acid (c26:0) 1,00 0,74 1,00 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 galactose 1,00 1,29 1,42 g-aminobutyric acid 1,00 1,16 1,32 gamma-tocopherol 1,00 0,54 0,60 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 isoleucine 1,00 1,28 1,66 iso-maltose 1,00 2,63 3,02 isopentenyl pyrophosphate 1,00 1,80 2,62 leucine 1,00 1,34 1,74 lignoceric acid (c24:0) 1,00 0,91 1,02 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 malate 1,00 2,91 3,46 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 ornithine 1,70 1,52 palmitic acid (c16:0) 1,00 1,16 1,38 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 praline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 sinapine acid 1,00 2,74 3,44 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 zeaxanthine 1,00 1,27 1,34 YCL027W metabolite Control 4 days 8 days Control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 2-hydroxy-palmitic acid 1,00 1,11 1,25 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 alanine 1,00 0,64 0,64 alpha linolenic acid (c18:3 (c9, c12, c15)) 1,00 1,24 1,40 alpha-tocopherol 1,00 1,05 1,14 aminoadipic acid 1,00 1,73 1,65 anhydroglucose 1,00 1,02 1,16 arginine 1,00 0,39 0,33 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 beta-sitosterol 1,00 1,39 1,51 beta-tocopherol 1,00 0,54 0,60 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid (c16:2 me) 1,00 1,01 1,04 hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 cerotic acid (c26:0) 1,00 0,74 1,00 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 0,79 0,74 0,80 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 galactose 1,00 1,29 1,42 g-aminobutyric acid 1,00 1,16 1,32 gamma-tocopherol 1,00 0,54 0,60 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 isoleucine 1,00 1,28 1,66 iso-maltose 1,00 2,63 3,02 isopentenyl pyrophosphate 1,00 1,80 2,62 leucine 1,00 1,34 1,74 lignoceric acid (c24:0) 1,00 0,91 1,02 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 malate 1,00 2,91 3,46 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 ornithine palmitic acid (c16:0) 1,00 1,16 1,38 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 praline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 sinapine acid 1,00 2,74 3,44 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 zeaxanthine 1,00 1,27 1,34 YNL079C metabolite Control 4 days 8 days Control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 0,59 2-hydroxy-palmitic acid 1,00 1,11 1,25 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 alanine 1,00 0,64 0,64 alpha linolenic acid (c18:3 (c9, c12, c15)) 1,00 1,24 1,40 1,53 1,56 alpha-tocopherol 1,00 1,05 1,14 2,64 3,66 aminoadipic acid 1,00 1,73 1,65 anhydroglucose 1,00 1,02 1,16 arginine 1,00 0,39 0,33 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 1,26 1,20 beta-sitosterol 1,00 1,39 1,51 beta-tocopherol 1,00 0,54 0,60 0,73 0,56 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid (c16:2 me) 1,00 1,01 1,04 hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 1,22 1,53 1,36 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 1,79 1,82 cerotic acid (c26:0) 1,00 0,74 1,00 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 galactose 1,00 1,29 1,42 g-aminobutyric acid 1,00 1,16 1,32 gamma-tocopherol 1,00 0,54 0,60 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 4,73 6,12 isoleucine 1,00 1,28 1,66 iso-maltose 1,00 2,63 3,02 4,42 4,93 isopentenyl pyrophosphate 1,00 1,80 2,62 leucine 1,00 1,34 1,74 1,51 2,19 lignoceric acid (c24:0) 1,00 0,91 1,02 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 malate 1,00 2,91 3,46 1,49 5,72 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 ornithine palmitic acid (c16:0) 1,00 1,16 1,38 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 praline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 sinapine acid 1,00 2,74 3,44 3,89 2,79 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 2,68 2,98 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 0,88 1,02 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 zeaxanthine 1,00 1,27 1,34 wild type YNL090W metabolite Control 4 days 8 days Control 4 days 8 days 2,3-dimethyl-5-phytylquinol 1,00 0,50 0,54 2-hydroxy-palmitic acid 1,00 1,11 1,25 1,15 1,25 3,4-dihydroxyphenylalanine (=dopa) 1,00 1,83 3,37 3-hydroxy-palmitic acid 1,00 5-oxoproline 1,00 1,56 1,81 alanine 1,00 0,64 0,64 alpha linolenic acid (c1 8:3 (c9, c1 2, c1 5)) 1,00 1,24 1,40 alpha-tocopherol 1,00 1,05 1,14 1,30 5,28 aminoadipic acid 1,00 1,73 1,65 anhydroglucose 1,00 1,02 1,16 arginine 1,00 0,39 0,33 0,85 aspartic acid 1,00 2,72 2,96 beta-apo-8' carotenal 1,00 1,21 1,22 beta-carotene 1,00 1,25 1,26 1,15 1,91 beta-sitosterol 1,00 1,39 1,51 beta-tocopherol 1,00 0,54 0,60 palmitic acid 1,00 1,07 1,25 delta-7-cis, 1 0-cis-hexadecadienic acid 1,00 1,01 1,04 (c16:2 me) hexadecatrienic acid (c16:3 me) 1,00 1,19 1,29 margaric acid (c17:0 me) 1,00 1,19 1,28 delta-15-cis-tetracosenic acid (c24:1 me) 1,00 1,16 1,34 campesterol 1,00 1,32 1,65 cerotic acid (c26:0) 1,00 0,74 1,00 2,98 3,93 citrulline 1,00 0,51 0,33 cryptoxanthine 1,00 1,00 0,90 eicosenoic acid (20:1) 1,00 0,81 0,81 ferulic acid 1,00 1,37 1,47 fructose 1,00 14,10 19,78 fumarate 1,00 5,19 9,33 0,76 galactose 1,00 1,29 1,42 g-aminobutyric acid 1,00 1,16 1,32 gamma-tocopherol 1,00 0,54 0,60 1,69 gluconic acid 1,00 2,24 3,08 glucose 1,00 14,97 20,73 glutamine 1,00 0,98 1,17 glutamic acid 1,00 2,01 2,69 glycerate 1,00 1,87 2,04 glycerinaldehyd 1,00 1,11 1,12 glycerol 1,00 1,22 1,29 glycerol-3-phosphate 1,00 1,86 2,41 glycine 1,00 0,25 0,26 homoserine 1,00 0,61 0,69 inositol 1,00 4,19 6,32 1,46 9,70 isoleucine 1,00 1,28 1,66 3,54 4,86 iso-maltose 1,00 2,63 3,02 3,59 20,72 14,65 isopentenyl pyrophosphate 1,00 1,80 2,62 1,79 leucine 1,00 1,34 1,74 lignoceric acid (c24:0) 1,00 0,91 1,02 linoleic acid (c18:2 (c9, c12)) 1,00 1,19 1,38 luteine 1,00 1,26 1,33 malate 1,00 2,91 3,46 2,12 14,49 mannose 1,00 16,40 17,80 triacontanoic acid 1,00 1,26 1,23 methionine 1,00 1,13 1,12 methylgalactofuranoside 1,00 1,24 1,49 methylgalactopyranoside 1,00 1,25 1,36 ornithine palmitic acid (c16:0) 1,00 1,16 1,38 phenylalanine 1,00 0,92 1,10 phosphate 1,00 2,15 2,73 proline 1,00 1,23 4,77 putrescine 1,00 0,39 pyruvate 1,00 1,30 1,21 raffinose 1,00 17,04 74,78 ribonic acid 1,00 2,32 3,43 serine 1,00 0,98 1,13 shikimate 1,00 1,11 1,07 sinapine acid 1,00 2,74 3,44 stearic acid (c18:0) 1,00 1,18 1,35 succinate 1,00 2,98 3,49 sucrose 1,00 1,42 1,70 threonine 1,00 1,26 1,68 tryptophane 1,00 1,13 1,89 tyrosine 1,00 1,56 2,01 ubichinone 1,00 1,02 1,20 udp-glucose 1,00 1,53 1,94 valine 1,00 0,98 1,18 1,13 1,55 1,80 zeaxanthine 1,00 1,27 1,34 0366.0.1 Example 2 0367.0.1 Engineering stress-tolerant Arabidopsis plants by over-expressing stress related protein encoding genes from Saccharomyces cereviesae or E. coli 5 or Brassica napus, Glycine max, and Oryza sativa using stress-inducible and tissue-specific promoters. 0368.0.1 Transgenic Arabidopsis plants were created as in example 1 to express the stress related protein encoding transgenes under the control of either a tissue specific or stress-inducible promoter. Constitutive expression of a transgene may 10 cause deleterious side effects. Stress inducible expression was achieved using promoters selected from those listed above in Table 1. 0369.0.1 T2 generation plants were produced and treated with drought stress in two experiments. For the first drought experiment, the plants were deprived of water until the plant and soil were desiccated. At various times after withholding water, a 15 normal watering schedule was resumed and the plants were grown to maturity. Seed yield was determined as seeds per plant. At an equivalent degree of drought stress, tolerant plants were able to resume normal growth and produced more seeds than non transgenic control plants. Proline content of the leaves and stomatal aperture were also measured at various times during the drought stress. Tolerant plants maintained a 20 lower proline content and a greater stomatal aperture than the non-transgenic control plants. 0370.0.1 An alternative method to impose water stress on the transgenic plants was by treatment with water containing an osmolyte such as polyethylene glycol (PEG) at specific water potential. Since PEG may be toxic, the plants were given only a short term exposure and then normal watering was resumed. As above, seed yields were measured from the mature plants. The response was measured during the stress period by physical measurements, such as stomatal aperture or osmotic potential, or biochemical measurements, such as accumulation of proline. Tolerant plants had 5 higher seed yields, maintained their stomatal aperture and showed only slight changes in osmotic potential and proline levels, whereas the susceptible non-transgenic control plants closed their stomata and exhibited increased osmotic potential and proline levels. 0371.0.1 The transgenic plants with a constitutive promoter controlling 10 transcription of the transgene were compared to those plants with a drought-inducible promoter in the absence of stress. The results indicated that the metabolite and gene expression changes did not occur when plants with the stress-inducible promoter were grown in the absence of stress. These plants also had higher seed yields than those with the constitutive promoter. 15 0372.0.1 Example 3 0373.0.1 Over-expression of stress related genes from Saccharomyces cerevisiae or E. coli or Brassica napus, Glycine max, and Oryza sativa provides tolerance of multiple abiotic stresses. 0374.0.1 Plants that exhibit tolerance of one abiotic stress often exhibit tolerance 20 of another environmental stress or an oxygen free radical generating herbicide. This phenomenon of cross-tolerance is not understood at a mechanistic level (McKersie and Leshem, 1994). Nonetheless, it is reasonable to expect that plants exhibiting enhanced drought tolerance due to the expression of a transgene might also exhibit tolerance of low temperatures, freezing, salt, air pollutants such as ozone, and other abiotic 25 stresses. In support of this hypothesis, the expression of several genes are up or down-regulated by multiple abiotic stress factors including cold, salt, osmoticum, ABA, etc (e.g. Hong et al. (1992) Developmental and organ-specific expression of an ABA and stress-induced protein in barley. Plant Mol Biol 18: 663-674; Jagendorf and Takabe (2001) Inducers of glycinebetaine synthesis in barley. Plant Physiol 127: 1827 30 1835); Mizoguchi et al. (1996) A gene encoding a mitogen-activated protein kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana. Proc Natl Acad Sci U S A 93: 765-769; Zhu (2001) Cell signaling under salt, water and cold stresses. Curr Opin Plant Biol 4: 401-406). 35 0375.0.1 To determine salt tolerance, seeds of Arabidopsis thaliana were sterilized (100% bleach, 0.1% TritonX for five minutes two times and rinsed five times with ddH2O). Seeds were plated on non-selection media (1/2 MS, 0.6% phytagar, 0.5g/L MES, 1% sucrose, 2 pg/ml benamyl). Seeds are allowed to germinate for approximately ten days. At the 4-5 leaf stage, transgenic plants were potted into 5.5cm diameter pots and allowed to grow (22 'C, continuous light) for approximately seven days, watering as needed. To begin the assay, two liters of 100 mM NaCl and 1/8 MS 5 was added to the tray under the pots. To the tray containing the control plants, three liters of 1/8 MS was added. The concentrations of NaCl supplementation were increased stepwise by 50 mM every 4 days up to 200 mM. After the salt treatment with 200 mM, fresh and dry weights of the plants as well as seed yields were determined. 0376.0.1 To determine cold tolerance, seeds of the transgenic and cold lines were 10 germinated and grown for approximately 10 days to the 4-5 leaf stage as above. The plants were then transferred to cold temperatures (5 'C) and grown through the flowering and seed set stages of development. Photosynthesis was measured using chlorophyll fluorescence as an indicator of photosynthetic fitness and integrity of the photosystems. Seed yield and plant dry weight were measured as an indictor of plant 15 biomass production. 0377.0.1 Plants that had tolerance to salinity or cold had higher seed yields, photosynthesis and dry matter production than susceptible plants. 0378.0.1 Example 4 0379.0.1 Engineering stress-tolerant alfalfa plants by over-expressing stress 20 related genes from Saccharomyces cerevisiae or E. coli or Brassica napus, Glycine max, and Oryza sativa 0380.0.1 A regenerating clone of alfalfa (Medicago sativa) was transformed using the method of (McKersie et al., 1999 Plant Physiol 119: 839-847). Regeneration and transformation of alfalfa is genotype dependent and therefore a regenerating plant is 25 required. Methods to obtain regenerating plants have been described. For example, these can be selected from the cultivar Rangelander (Agriculture Canada) or any other commercial alfalfa variety as described by Brown DCW and A Atanassov (1985. Plant Cell Tissue Organ Culture 4: 111-112). Alternatively, the RA3 variety (University of Wisconsin) has been selected for use in tissue culture (Walker et al., 1978 Am J Bot 30 65:654-659). 0381.0.1 Petiole explants were cocultivated with an overnight culture of Agrobacterium tumefaciens C58C1 pMP90 (McKersie et al., 1999 Plant Physiol 119: 839-847) or LBA4404 containing a binary vector. Many different binary vector systems have been described for plant transformation (e.g. An, G. in Agrobacterium Protocols. 35 Methods in Molecular Biology vol 44, pp 47-62, Gartland KMA and MR Davey eds. Humana Press, Totowa, New Jersey). Many are based on the vector pBIN19 described by Bevan (Nucleic Acid Research. 1984. 12:8711-8721) that includes a plant gene expression cassette flanked by the left and right border sequences from the Ti plasmid of Agrobacterium tumefaciens. A plant gene expression cassette consists of at least two genes - a selection marker gene and a plant promoter regulating the transcription of the cDNA or genomic DNA of the trait gene. Various selection marker genes can be 5 used including the Arabidopsis gene encoding a mutated acetohydroxy acid synthase (AHAS) enzyme (US patents 57673666 and 6225105). Similarly, various promoters can be used to regulate the trait gene that provides constitutive, developmental, tissue or environmental regulation of gene transcription. In this example, the 34S promoter (GenBank Accession numbers M59930 and X16673) was used to provide constitutive 10 expression of the trait gene. 0382.0.1 The explants were cocultivated for 3 d in the dark on SH induction medium containing 288 mg/ L Pro, 53 mg/ L thioproline, 4.35 g/ L K2SO4, and 100 pm acetosyringinone. The explants were washed in half-strength Murashige-Skoog medium (Murashige and Skoog, 1962) and plated on the same SH induction medium 15 without acetosyringinone but with a suitable selection agent and suitable antibiotic to inhibit Agrobacterium growth. After several weeks, somatic embryos were transferred to BOi2Y development medium containing no growth regulators, no antibiotics, and 50 g/ L sucrose. Somatic embryos were subsequently germinated on half-strength Murashige-Skoog medium. Rooted seedlings were transplanted into pots and grown in 20 a greenhouse. 0383.0.1 The TO transgenic plants were propagated by node cuttings and rooted in Turface growth medium. The plants were defoliated and grown to a height of about 10 cm (approximately 2 weeks after defoliation). The plants were then subjected to drought stress in two experiments. 25 0384.0.1 For the first drought experiment, the seedlings received no water for a period up to 3 weeks at which time the plant and soil were desiccated. At various times after withholding water, a normal watering schedule was resumed. At one week after resuming watering, the fresh and dry weights of the shoots was determined. At an equivalent degree of drought stress, tolerant plants were able to resume normal growth 30 whereas susceptible plants had died or suffered significant injury resulting in less dry matter. Proline content of the leaves and stomatal aperture were also measured at various times during the drought stress. Tolerant plants maintained a lower proline content and a greater stomatal aperture than the non-transgenic control plants. 0385.0.1 An alternative method to impose water stress on the transgenic plants 35 was by treatment with a solution at specific water potential, containing an osmolyte such as polyethylene glycol (PEG). The PEG treatment was given to either detached leaves (e.g. Djilianov et al., 1997 Plant Science 129: 147-156) or to the roots (Wakabayashi et al., 1997 Plant Physiol 113: 967-973). Since PEG may be toxic, the plants were given only a short term exposure. The response was measured as physical measurements such as stomatal aperture or osmotic potential, or biochemical measurements such as accumulation of proline. Tolerant plants maintained their 5 stomatal aperture and showed only slight changes in osmotic potential, whereas the susceptible non-transgenic control plants closed their stomata and exhibited increased osmotic potential. In addition the changes in proline and other metabolites were less in the tolerant transgenic plants than in the non-transgenic control plants. 0386.0.1 Tolerance of salinity and cold were measured using methods as 10 described in example 3. Plants that had tolerance to salinity or cold had higher seed yields, photosynthesis and dry matter production than susceptible plants. 0387.0.1 Example 5 0388.0.1 Engineering stress-tolerant ryegrass plants by over-expressing stress related genes from Saccharomyces cerevisiae or E. coli or Brassica napus, 15 Glycine max, and Oryza sativa 0389.0.1 Seeds of several different ryegrass varieties may be used as explant sources for transformation, including the commercial variety Gunne available from Svalof Weibull seed company or the variety Affinity. Seeds were surface-sterilized sequentially with 1% Tween-20 for 1 minute, 100 % bleach for 60 minutes, 3 rinses 20 with 5 minutes each with de-ionized and distilled H20, and then germinated for 3-4 days on moist, sterile filter paper in the dark. Seedlings were further sterilized for 1 minute with 1% Tween-20, 5 minutes with 75% bleach, and rinsed 3 times with ddH2O, 5 min each. 0390.0.1 Surface-sterilized seeds were placed on the callus induction medium 25 containing Murashige and Skoog basal salts and vitamins, 20 g/I sucrose, 150 mg/I asparagine, 500 mg/I casein hydrolysate, 3 g/I Phytagel, 10 mg/I BAP, and 5 mg/I dicamba. Plates were incubated in the dark at 25C for 4 weeks for seed germination and embryogenic callus induction. 0391.0.1 After 4 weeks on the callus induction medium, the shoots and roots of 30 the seedlings were trimmed away, the callus was transferred to fresh media, maintained in culture for another 4 weeks, and then transferred to MSO medium in light for 2 weeks. Several pieces of callus (11-17 weeks old) were either strained through a 10 mesh sieve and put onto callus induction medium, or cultured in 100 ml of liquid ryegrass callus induction media (same medium as for callus induction with agar) in a 35 250 ml flask. The flask was wrapped in foil and shaken at 175 rpm in the dark at 23 C for 1 week. Sieving the liquid culture with a 40-mesh sieve collected the cells. The fraction collected on the sieve was plated and cultured on solid ryegrass callus induction medium for 1 week in the dark at 25C. The callus was then transferred to and cultured on MS medium containing 1 % sucrose for 2 weeks. 0392.0.1 Transformation can be accomplished with either Agrobacterium of with particle bombardment methods. An expression vector is created containing a 5 constitutive plant promoter and the cDNA of the gene in a pUC vector. The plasmid DNA was prepared from E. coli cells using with Qiagen kit according to manufacturer's instruction. Approximately 2 g of embryogenic callus was spread in the center of a sterile filter paper in a Petri dish. An aliquot of liquid MSO with 10 g/I sucrose was added to the filter paper. Gold particles (1.0 pm in size) were coated with plasmid DNA 10 according to method of Sanford et al., 1993 and delivered to the embryogenic callus with the following parameters: 500 pg particles and 2 pg DNA per shot, 1300 psi and a target distance of 8.5 cm from stopping plate to plate of callus and 1 shot per plate of callus. 0393.0.1 After the bombardment, calli were transferred back to the fresh callus 15 development medium and maintained in the dark at room temperature for a 1-week period. The callus was then transferred to growth conditions in the light at 25 'C to initiate embryo differentiation with the appropriate selection agent, e.g. 250 nM Arsenal, 5 mg/I PPT or 50 mg/L kanamycin. Shoots resistant to the selection agent appeared and once rotted were transferred to soil. 20 0394.0.1 Samples of the primary transgenic plants (TO) are analyzed by PCR to confirm the presence of T-DNA. These results are confirmed by Southern hybridization in which DNA is electrophoresed on a 1% agarose gel and transferred to a positively charged nylon membrane (Roche Diagnostics). The PCR DIG Probe Synthesis Kit (Roche Diagnostics) is used to prepare a digoxigenin-labelled probe by PCR, and used 25 as recommended by the manufacturer. 0395.0.1 Transgenic TO ryegrass plants were propagated vegetatively by excising tillers. The transplanted tillers were maintained in the greenhouse for 2 months until well established. The shoots were defoliated and allowed to grow for 2 weeks. 0396.0.1 The first drought experiment was conducted in a manner similar to that 30 described in example 3. The seedlings received no water for a period up to 3 weeks at which time the plant and soil were desiccated. At various times after withholding water, a normal watering schedule was resumed. At one week after resuming watering, the lengths of leaf blades, and the fresh and dry weights of the shoots was determined. At an equivalent degree of drought stress, tolerant plants were able to resume normal 35 growth whereas susceptible plants had died or suffered significant injury resulting in shorter leaves and less dry matter. Proline content of the leaves and stomatal aperture were also measured at various times during the drought stress. Tolerant plants maintained a lower proline content and a greater stomatal aperture than the non transgenic control plants. 0397.0.1 A second experiment imposing drought stress on the transgenic plants was by treatment with a solution of PEG as described in the previous examples. 5 Tolerance of salinity and cold were measured using methods as described in example 3. Plants that had tolerance to salinity or cold had higher seed yields, photosynthesis and dry matter production than susceptible plants. 0398.0.1 Example 6 0399.0.1 Engineering stress-tolerant soybean plants by over-expressing 10 stress related genes from Saccharomyces cerevisiae or E. coli or Brassica napus, Glycine max, and Oryza sativa 0400.0.1 Soybean was transformed according to the following modification of the method described in the Texas A&M patent US 5,164,310. Several commercial soybean varieties are amenable to transformation by this method. The cultivar Jack 15 (available from the Illinois Seed Foundation) is a commonly used for transformation. Seeds were sterilized by immersion in 70% (v/v) ethanol for 6 min and in 25 % commercial bleach (NaOCI) supplemented with 0.1% (v/v) Tween for 20 min, followed by rinsing 4 times with sterile double distilled water. Seven-day seedlings were propagated by removing the radical, hypocotyl and one cotyledon from each seedling. 20 Then, the epicotyl with one cotyledon was transferred to fresh germination media in petri dishes and incubated at 25 'C under a 16-hr photoperiod (approx. 100 VtE-m-2s-1) for three weeks. Axillary nodes (approx. 4 mm in length) were cut from 3 - 4 week-old plants. Axillary nodes were excised and incubated in Agrobacterium LBA4404 culture. 0401.0.1 Many different binary vector systems have been described for plant 25 transformation (e.g. An, G. in Agrobacterium Protocols. Methods in Molecular Biology vol 44, pp 47-62, Gartland KMA and MR Davey eds. Humana Press, Totowa, New Jersey). Many are based on the vector pBIN19 described by Bevan (Nucleic Acid Research. 1984. 12:8711-8721) that includes a plant gene expression cassette flanked by the left and right border sequences from the Ti plasmid of Agrobacterium 30 tumefaciens. A plant gene expression cassette consists of at least two genes - a selection marker gene and a plant promoter regulating the transcription of the cDNA or genomic DNA of the trait gene. Various selection marker genes can be used including the Arabidopsis gene encoding a mutated acetohydroxy acid synthase (AHAS) enzyme (US patents 57673666 and 6225105). Similarly, various promoters can be used to 35 regulate the trait gene to provide constitutive, developmental, tissue or environmental regulation of gene transcription. In this example, the 34S promoter (GenBank Accession numbers M59930 and X16673) was used to provide constitutive expression of the trait gene. 0402.0.1 After the co-cultivation treatment, the explants were washed and transferred to selection media supplemented with 500 mg/L timentin. Shoots were 5 excised and placed on a shoot elongation medium. Shoots longer than 1 cm were placed on rooting medium for two to four weeks prior to transplanting to soil. 0403.0.1 The primary transgenic plants (TO) were analyzed by PCR to confirm the presence of T-DNA. These results were confirmed by Southern hybridization in which DNA is electrophoresed on a 1 % agarose gel and transferred to a positively charged 10 nylon membrane (Roche Diagnostics). The PCR DIG Probe Synthesis Kit (Roche Diagnostics) is used to prepare a digoxigenin-labelled probe by PCR, and used as recommended by the manufacturer. 0404.0.1 Tolerant plants had higher seed yields, maintained their stomatal aperture and showed only slight changes in osmotic potential and proline levels, 15 whereas the susceptible non-transgenic control plants closed their stomata and exhibited increased osmotic potential and proline levels. 0405.0.1 Tolerance of drought, salinity and cold were measured using methods as described in example3. Plants that had tolerance to salinity or cold had higher seed yields, photosynthesis and dry matter production than susceptible plants. 20 0406.0.1 Example 7 0407.0.1 Engineering stress-tolerant Rapeseed/Canola plants by over expressing stress related genes from Saccharomyces cerevisiae or E. coli or Brassica napus, Glycine max, and Oryza sativa 0408.0.1 Cotyledonary petioles and hypocotyls of 5-6 day-old young seedlings 25 were used as explants for tissue culture and transformed according to Babic et al.(1998, Plant Cell Rep 17: 183-188). The commercial cultivar Westar (Agriculture Canada) is the standard variety used for transformation, but other varieties can be used. 0409.0.1 Agrobacterium tumefaciens LBA4404 containing a binary vector was 30 used for canola transformation. Many different binary vector systems have been described for plant transformation (e.g. An, G. in Agrobacterium Protocols. Methods in Molecular Biology vol 44, pp 47-62, Gartland KMA and MR Davey eds. Humana Press, Totowa, New Jersey). Many are based on the vector pBIN19 described by Bevan (Nucleic Acid Research. 1984. 12:8711-8721) that includes a plant gene expression 35 cassette flanked by the left and right border sequences from the Ti plasmid of Agrobacterium tumefaciens. A plant gene expression cassette consists of at least two genes - a selection marker gene and a plant promoter regulating the transcription of the cDNA or genomic DNA of the trait gene. Various selection marker genes can be used including the Arabidopsis gene encoding a mutated acetohydroxy acid synthase (AHAS) enzyme (US patents 57673666 and 6225105). Similarly, various promoters can be used to regulate the trait gene to provide constitutive, developmental, tissue or 5 environmental regulation of gene transcription. In this example, the 34S promoter (GenBank Accession numbers M59930 and X16673) was used to provide constitutive expression of the trait gene. 0410.0.1 Canola seeds were surface-sterilized in 70% ethanol for 2 min., and then in 30% Clorox with a drop of Tween-20 for 10 min, followed by three rinses with 10 sterilized distilled water. Seeds were then germinated in vitro 5 days on half strength MS medium without hormones, 1% sucrose, 0.7% Phytagar at 23oC, 16 hr. light. The cotyledon petiole explants with the cotyledon attached were excised from the in vitro seedlings, and inoculated with Agrobacterium by dipping the cut end of the petiole explant into the bacterial suspension. The explants were then cultured for 2 days on 15 MSBAP-3 medium containing 3 mg/I BAP, 3 % sucrose, 0.7 % Phytagar at 23 'C, 16 hr light. After two days of co-cultivation with Agrobacterium, the petiole explants were transferred to MSBAP-3 medium containing 3 mg/I BAP, cefotaxime, carbenicillin, or timentin (300 mg/I) for 7 days, and then cultured on MSBAP-3 medium with cefotaxime, carbenicillin, or timentin and selection agent until shoot regeneration. When the shoots 20 were 5 - 10 mm in length, they were cut and transferred to shoot elongation medium (MSBAP-0.5, containing 0.5 mg/I BAP). Shoots of about 2 cm in length were transferred to the rooting medium (MSO) for root induction. 0411.0.1 Samples of the primary transgenic plants (TO) were analyzed by PCR to confirm the presence of T-DNA. These results were confirmed by Southern 25 hybridization in which DNA is electrophoresed on a 1 % agarose gel and transferred to a positively charged nylon membrane (Roche Diagnostics). The PCR DIG Probe Synthesis Kit (Roche Diagnostics) is used to prepare a digoxigenin-labelled probe by PCR, and used as recommended by the manufacturer. 0412.0.1 The transgenic plants were then evaluated for their improved stress 30 tolerance according to the method described in Example 3. Tolerant plants had higher seed yields, maintained their stomatal aperture and showed only slight changes in osmotic potential and proline levels, whereas the susceptible non-transgenic control plants closed their stomata and exhibited increased osmotic potential and proline levels. 35 0413.0.1 Tolerance of drought, salinity and cold were measured using methods as described in the previous example 3. Plants that had tolerance to salinity or cold had higher seed yields, photosynthesis and dry matter production than susceptible plants.

0414.0.1 Example 8 0415.0.1 Engineering stress-tolerant corn plants by over-expressing stress related genes from Saccharomyces cerevisiae or E. coli or Brassica napus, Glycine max, and Oryza sativa 5 0416.0.1 Transformation of maize (Zea Mays L.) is performed with a modification of the method described by Ishida et al. (1996. Nature Biotech 14745-50). Transformation is genotype-dependent in corn and only specific genotypes are amenable to transformation and regeneration. The inbred line A188 (University of Minnesota) or hybrids with A188 as a parent are good sources of donor material for 10 transformation (Fromm et al. 1990 Biotech 8:833-839), but other genotypes can be used successfully as well. Ears are harvested from corn plants at approximately 11 days after pollination (DAP) when the length of immature embryos is about 1 to 1.2 mm. Immature embryos are co-cultivated with Agrobacterium tumefaciens that carry "super binary" vectors and transgenic plants are recovered through organogenesis. 15 The super binary vector system of Japan Tobacco is described in WO patents W094/00977 and W095/06722. Vectors were constructed as described. Various selection marker genes can be used including the maize gene encoding a mutated acetohydroxy acid synthase (AHAS) enzyme (US patent 6025541). Similarly, various promoters can be used to regulate the trait gene to provide constitutive, developmental, 20 tissue or environmental regulation of gene transcription. In this example, the 34S promoter (GenBank Accession numbers M59930 and X16673) was used to provide constitutive expression of the trait gene. 0417.0.1 Excised embryos are grown on callus induction medium, then maize regeneration medium, containing imidazolinone as a selection agent. The Petri plates 25 are incubated in the light at 25 'C for 2-3 weeks, or until shoots develop. The green shoots are transferred from each embryo to maize rooting medium and incubated at 25 'C for 2-3 weeks, until roots develop. The rooted shoots are transplanted to soil in the greenhouse. T1 seeds are produced from plants that exhibit tolerance to the imidazolinone herbicides and which are PCR positive for the transgenes. 30 0418.0.1 The T1 transgenic plants were then evaluated for their improved stress tolerance according to the method described in Example 3. The T1 generation of single locus insertions of the T-DNA will segregate for the transgene in a 3:1 ratio. Those progeny containing one or two copies of the transgene are tolerant of the imidazolinone herbicide, and exhibit greater tolerance of drought stress than those progeny lacking 35 the transgenes. Tolerant plants had higher seed yields, maintained their stomatal aperture and showed only slight changes in osmotic potential and proline levels, whereas the susceptible non-transgenic control plants closed their stomata and exhibited increased osmotic potential and proline levels. Homozygous T2 plants exhibited similar phenotypes. Hybrid plants (F1 progeny) of homozygous transgenic plants and non-transgenic plants also exhibited increased environmental stress tolerance. 5 0419.0.1 Tolerance of salinity and cold were measured using methods as described in the previous example 3. Plants that had tolerance to drought, salinity or cold had higher seed yields, photosynthesis and dry matter production than susceptible plants. 0420.0.1 Example 9 10 0421.0.1 Engineering stress-tolerant wheat plants by over-expressing stress related genes from Saccharomyces cerevisiae or E. coli, Brassica napus, Glycine max, or Oryza sativa 0422.0.1 Transformation of wheat is performed with the method described by Ishida et al. (1996 Nature Biotech. 14745-50). The cultivar Bobwhite (available from 15 CYMMIT, Mexico) is commonly used in transformation. Immature embryos are co cultivated with Agrobacterium tumefaciens that carry "super binary" vectors, and transgenic plants are recovered through organogenesis. The super binary vector system of Japan Tobacco is described in WO patents W094/00977 and W095/06722. Vectors were constructed as described. Various selection marker genes can be used 20 including the maize gene encoding a mutated acetohydroxy acid synthase (AHAS) enzyme (US patent 6025541). Similarly, various promoters can be used to regulate the trait gene to provide constitutive, developmental, tissue or environmental regulation of gene transcription. In this example, the 34S promoter (GenBank Accession numbers M59930 and X1 6673) was used to provide constitutive expression of the trait gene. 25 0423.0.1 After incubation with Agrobacterium, the embryos are grown on callus induction medium, then regeneration medium, containing imidazolinone as a selection agent. The Petri plates are incubated in the light at 25 'C for 2-3 weeks, or until shoots develop. The green shoots are transferred from each embryo to rooting medium and incubated at 25 'C for 2-3 weeks, until roots develop. The rooted shoots are 30 transplanted to soil in the greenhouse. T1 seeds are produced from plants that exhibit tolerance to the imidazolinone herbicides and which are PCR positive for the transgenes. 0424.0.1 The T1 transgenic plants were then evaluated for their improved stress tolerance according to the method described in the previous example 3. The T1 35 generation of single locus insertions of the T-DNA will segregate for the transgene in a 3:1 ratio. Those progeny containing one or two copies of the transgene are tolerant of the imidazolinone herbicide, and exhibit greater tolerance of drought stress than those progeny lacking the transgenes. Tolerant plants had higher seed yields, maintained their stomatal aperture and showed only slight changes in osmotic potential and proline levels, whereas the susceptible non-transgenic control plants closed their stomata and exhibited increased osmotic potential and proline levels. Homozygous T2 plants 5 exhibited similar phenotypes. Tolerance of salinity and cold were measured using methods as described in the previous examples. Plants that had tolerance to drought, salinity or cold had higher seed yields, photosynthesis and dry matter production than susceptible plants. 0425.0.3 Example 14 10 0426.0.3 Identification of Identical and Heterologous Genes 0427.0.3 Gene sequences can be used to identify identical or heterologous genes from cDNA or genomic libraries. Identical genes (e. g. full-length cDNA clones) can be isolated via nucleic acid hybridization using for example cDNA libraries. Depending on the abundance of the gene of interest, 100,000 up to 1,000,000 recombinant 15 bacteriophages are plated and transferred to nylon membranes. After denaturation with alkali, DNA is immobilized on the membrane by e. g. UV cross linking. Hybridization is carried out at high stringency conditions. In aqueous solution, hybridization and washing is performed at an ionic strength of 1 M NaCl and a temperature of 68'C. Hybridization probes are generated by e.g. radioactive ( P) nick transcription labeling 20 (High Prime, Roche, Mannheim, Germany). Signals are detected by autoradiography. 0428.0.3 Partially identical or heterologous genes that are related but not identical can be identified in a manner analogous to the above-described procedure using low stringency hybridization and washing conditions. For aqueous hybridization, the ionic strength is normally kept at 1 M NaCl while the temperature is progressively lowered 25 from 68 to 42'C. 0429.0.3 Isolation of gene sequences with homology (or sequence identity/similarity) only in a distinct domain of (for example 10-20 amino acids) can be carried out by using synthetic radio labeled oligonucleotide probes. Radiolabeled oligonucleotides are prepared by phosphorylation of the 5-prime end of two 30 complementary oligonucleotides with T4 polynucleotide kinase. The complementary oligonucleotides are annealed and ligated to form concatemers. The double stranded concatemers are than radiolabeled by, for example, nick transcription. Hybridization is normally performed at low stringency conditions using high oligonucleotide concentrations. 35 Oligonucleotide hybridization solution: 6 x SSC 0.01 M sodium phosphate 1 mM EDTA (pH 8) 0.5 % SDS 100 pg/ml denatured salmon sperm DNA 0.1 % nonfat dried milk 0430.0.3 During hybridization, temperature is lowered stepwise to 5-10'C below 5 the estimated oligonucleotide Tm or down to room temperature followed by washing steps and autoradiography. Washing is performed with low stringency such as 3 washing steps using 4 x SSC. Further details are described by Sambrook, J. et al., 1989, "Molecular Cloning: A Laboratory Manual," Cold Spring Harbor Laboratory Press or Ausubel, F.M. et al., 1994, "Current Protocols in Molecular Biology," John Wiley & 10 Sons. 0431.0.3 Example 15 0432.0.3 Identification of Identical Genes by Screening Expression Libraries with Antibodies 0433.0.3 c-DNA clones can be used to produce recombinant polypeptide for 15 example in E. coli (e.g. Qiagen QlAexpress pQE system). Recombinant polypeptides are then normally affinity purified via Ni-NTA affinity chromatography (Qiagen). Recombinant polypeptides are then used to produce specific antibodies for example by using standard techniques for rabbit immunization. Antibodies are affinity purified using a Ni-NTA column saturated with the recombinant antigen as described by Gu et 20 al., 1994, BioTechniques 17:257-262. The antibody can than be used to screen expression cDNA libraries to identify identical or heterologous genes via an immunological screening (Sambrook, J. et al., 1989, "Molecular Cloning: A Laboratory Manual," Cold Spring Harbor Laboratory Press or Ausubel, F.M. et al., 1994, "Current Protocols in Molecular Biology", John Wiley & Sons). 25 0434.0.3 Example 16 0435.0.3 In vivo Mutagenesis 0436.0.3 In vivo mutagenesis of microorganisms can be performed by passage of plasmid (or other vector) DNA through E. coli or other microorganisms (e.g. Bacillus spp. or yeasts such as Saccharomyces cerevisiae) which are impaired in their 30 capabilities to maintain the integrity of their genetic information. Typical mutator strains have mutations in the genes for the DNA repair system (e.g., mutHLS, mutD, mutT, etc.; for reference, see Rupp, W.D., 1996, DNA repair mechanisms, in: Escherichia co/i and Salmonella, p. 2277-2294, ASM: Washington.) Such strains are well known to those skilled in the art. The use of such strains is illustrated, for example, in Greener, 35 A. and Callahan, M., 1994, Strategies 7: 32-34. Transfer of mutated DNA molecules into plants is preferably done after selection and testing in microorganisms. Transgenic plants are generated according to various examples within the exemplification of this document.

0437.0.3 Example 17 0438.0.3 Identification and Analysis of YNL090W Homologs 0439.0.3 Transgenic Arabidopsis plants overexpressing YNL 090W (ORF 3165) lived 4.33 days longer than the wild type control under drought conditions. The protein 5 sequence of YNL090W was used to identify related gene sequences of expressed sequence tags (ESTs) proprietary libraries constructed from Oryza sativa cv. Noppon Brarre (a japonica rice), Brassica napus cv. "AC Excel" "Quantum" and "Cresor" (canola), and Glycine max cv. Resuick (soybean) by Blast analysis (Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. 1990 J Mol Biol 21593:403-10). 10 0440.0.3 The plant cDNA sequences were translated into a predicated amino acid sequences, and relationship among the amino acids sequences was determined by sequence alignment using the clustal W alogorithm in Vector NTI Version 7 (Figure 1 1). They have 75% similarity overall. In general, proteins having conserved domains 15 referred to as I (GXXXGKT), II (DXXG), III (VGTK), IV (EXSS), and E (FXXXYXX), are classified as small GTPases. All five domains in the proteins in Figure 1 are more conserved than in other known small GTPases, particularly Domain I (KXVXXGDXXXGKT) (SEQ ID NO: 557), Domain E (FXXXYXXTV) (SEQ ID NO: 558), Domain II (WDTAGQE) (SEQ ID NO: 559) and Domain III (VGTKXDL) (SEQ ID NO: 20 560). In addition, polybasic amino acids in C terminus are shown in the Figure 1-1, as well as a C-terminal CAAL domain (wherein A is an aliphatic amino acid), which is the signature sequence for post translational modification by the enzyme geranylgeranyltransferase 1. Another important Rho-specific feature was shown in most proteins in Figure 1-1 is the highly conserved amino acids between Domain II and 25 Domain III.

Claims

1. An isolated plant cell with increased tolerance and/or resistance to an environmental stress as compared to a corresponding wild type plant cell, 5 wherein said isolated plant cell overexpresses a Stress-Related Protein (SRP) coding nucleic acid molecule selected from the group consisting of: a) a nucleic acid molecule encoding a polypeptide shown in SEQ ID NO: 4, 6,8,10,12,14,16,18,20,22,24,26,28, 30,32, 34,36, 38,40,42,44, 46,48,50,52,54,56,58, 60,62, 64,66,68,70,72,74,76,78,80,82, 10 84,86,88,90,92,94,96,98,100,102,104,106,108,110,112,114, 116, 118, 120, 122,124,126,128,130,132,134,136,138,140,142, 144,146,148,150,152,154,156,158,160,162,164,166,168,170, 172, 174, 176, 178, 180,182,184,186, 188, 190, 192, 194, 196,198, 200,202,204,206,208,210,212,214,216,218,220,222,224,226, 15 228,230,232,234,236,238,240,242,244,246,248,250,252,254, 256,258,260,262,264,266,268,270,272,274,276,278,280,282, 284,286,288,290,292,294,296,298, 300, 302, 304, 306, 308,310, 313, 315, 317, 319, 321,323,325,327, 329, 331, 333, 335, 337,339, 341, 343, 345, 347, 349,351,353,355, 357, 359, 361, 363, 365,367, 20 369, 371, 373, 375, 377,379,381,383, 385, 387, 389, 391, 393,395, 397, 399,401,403,405,407,409,411,413,415,417,419,421,423, 425,427,429,431,433,435,437,439,441,443,445,447,449,451, 453,455,457,459,461,463,465,467,469,471,473,475,477,479, 481,483,485,487,489,491,493,495,497,499,501,503,505,507, 25 509,511,513,515,517,519,521,523,526,528,530,532,534,536, 538, 540, 542, 544, 546, 548, 550, 552, 554 and/or 556, or a fragment thereof; b) a nucleic acid molecule comprising a nucleic acid molecule shown in SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 30 37,39,41,43,45,47,49,51,53,55,57,59, 61,63, 65,67, 69,71,73, 75,77,79,81,83,85,87,89,91, 93,95, 97,99, 101,103,105, 107, 109, 111, 113, 115,117,119,121,123,125,127,129,131,133,135, 137, 139, 141,143,145,147,149,151,153,155,157,159,161,163, 165, 167, 169, 171, 173,175,177,179, 181, 183, 185, 187, 189,191, 35 193,195,197,199,201,203,205,207,209,211,213,215,217,219, 221,223,225,227,229,231,233,235,237,239,241,243,245,247, 249,251,253,255,257,259,261,263,265,267,269,271,273,275, 277,279,281,283,285,287,289,291,293,295,297,299, 301,303, 305, 307, 309, 311, 312,314,316,318, 320, 322, 324, 326, 328,330, 332, 334, 336, 338, 340,342,344,346, 348, 350, 352, 354, 356,358, 360, 362, 364, 366, 368,370,372,374, 376, 378, 380, 382, 384,386, 5 388, 390, 392, 394, 396,398,400,402,404,406,408,410,412,414, 416,418,420,422,424,426,428,430,432,434,436,438,440,442, 444,446,448,450,452,454,456,458,460,462,464,466,468,470, 472,474,476,478,480,482,484,486,488,490,492,494,496,498, 500,502,504,506,508,510,512,514,516,518,520,522,524,525, 10 527,529,531,533,535,537,539,541,543,545,547,549,551,553 and/or 555; c) a nucleic acid molecule whose sequence can be deduced from a polypeptide sequence encoded by a nucleic acid molecule of (a) or (b) as a result of the degeneracy of the genetic code; 15 d) a nucleic acid molecule which encodes a polypeptide which has at least 80% identity with an amino acid sequence of a polypeptide encoded by a nucleic acid molecule of (a) to (c); e) a nucleic acid molecule, or complement thereof, which hybridises with a nucleic acid molecule of (a) to (c) under stringent hybridisation 20 conditions ; f) a nucleic acid molecule which encompasses a nucleic acid molecule which is obtained by amplifying nucleic acid molecules from a cDNA library or a genomic library using the primers in table 2 and conferring an altered metabolic activity in an organism or a part thereof; 25 g) a nucleic acid molecule, or a complement thereof, encoding a polypeptide which is isolated with the aid of a monoclonal antibody raised against a polypeptide encoded by one of the nucleic acid molecules of (a) to (f); and h) a nucleic acid molecule which is obtained by screening a suitable nucleic 30 acid library under stringent hybridisation conditions with a probe comprising the sequence of a nucleic acid molecule of (a) to (g) or with a fragment thereof having at least 15 nt, preferably 20 nt, 30 nt, 50 nt, 100 nt, 200 nt or 500 nt of a nucleic acid molecule characterised in (a) to (g). 35

2. The isolated plant cell of claim 1 derived from a monocotyledonous plant or from a dicotyledonous plant.

3. The isolated plant cell of claim 1 derived from a gymnosperm plant.

4. A plant generated from an isolated plant cell according to claim 1 or 2 which is a monocot or dicot plant. 5

5. A plant generated from an isolated plant cell according to claim 1 or 3 and which is a gymnosperm plant.

6. A seed produced by a plant of claims 4 or 5, wherein the seed is genetically 10 homozygous for a nucleic acid sequence conferring an increased tolerance and/or resistance to environmental stress as compared to plant from which the seed is derived.

7. An agricultural product produced from an isolated plant cell according to any one 15 of claims 1 to 3, the plant of claim 4 or 5, or seed according to claim 6.

8. An isolated nucleic acid molecule when used to confer to a plant cell an increased tolerance and/or resistance to environmental stress when compared to a wild type plant cell, wherein said isolated nucleic acid molecule comprises a 20 nucleic acid molecule selected from the group consisting of: a) a nucleic acid molecule encoding a polypeptide shown in SEQ ID NO: 4, 6,8,10,12,14,16,18,20,22,24,26,28, 30,32, 34,36, 38,40,42,44, 46,48,50,52,54,56,58, 60,62, 64,66,68,70,72,74,76,78,80,82, 84,86,88,90, 92, 94,96, 98,100,102, 104, 106,108,110,112,114, 25 116,118,120,122,124,126,128,130,132,134,136,138,140,142, 144,146,148,150,152,154,156,158,160,162,164,166,168,170, 172, 174, 176, 178, 180,182,184,186, 188, 190, 192, 194, 196,198, 200,202,204,206,208,210,212,214,216,218,220,222,224,226, 228,230,232,234,236,238,240,242,244,246,248,250,252,254, 30 256,258,260,262,264,266,268,270,272,274,276,278,280,282, 284,286,288,290,292,294,296,298, 300, 302, 304, 306, 308,310, 313, 315, 317, 319, 321,323,325,327, 329, 331, 333, 335, 337,339, 341, 343, 345, 347, 349,351,353,355, 357, 359, 361, 363, 365,367, 369, 371, 373, 375, 377,379,381,383, 385, 387, 389, 391, 393,395, 35 397,399,401,403,405,407,409,411,413,415,417,419,421,423, 425,427,429,431,433,435,437,439,441,443,445,447,449,451, 453,455,457,459,461,463,465,467,469,471,473,475,477,479, 481,483,485,487,489,491,493,495,497,499,501,503,505,507, 509,511,513,515,517,519,521,523,526,528,530,532,534,536, 538, 540, 542, 544, 546, 548, 550, 552, 554 and/or 556, or a fragment thereof; 5 b) a nucleic acid molecule comprising a nucleic acid molecule shown in SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37,39,41,43,45,47,49,51,53,55,57,59, 61,63, 65,67, 69,71,73, 75,77,79,81,83,85,87,89,91, 93,95,97, 99,101, 103, 105, 107, 109, 111, 113,115,117,119,121,123,125,127,129,131,133,135, 10 137,139,141,143,145,147,149,151,153,155,157,159,161,163, 165, 167, 169, 171, 173,175,177,179, 181, 183, 185, 187, 189,191, 193,195,197,199,201,203,205,207,209,211,213,215,217,219, 221,223,225,227,229,231,233,235,237,239,241,243,245,247, 249,251,253,255,257,259,261,263,265,267,269,271,273,275, 15 277,279,281,283,285,287,289,291,293,295,297,299,301,303, 305, 307, 309, 311, 312,314,316,318, 320, 322, 324, 326, 328,330, 332, 334, 336, 338, 340,342,344,346, 348, 350, 352, 354, 356,358, 360, 362, 364, 366, 368,370,372,374, 376, 378, 380, 382, 384,386, 388, 390, 392, 394, 396,398,400,402,404,406,408,410,412,414, 20 416,418,420,422,424,426,428,430,432,434,436,438,440,442, 444,446,448,450,452,454,456,458,460,462,464,466,468,470, 472,474,476,478,480,482,484,486,488,490,492,494,496,498, 500,502,504,506,508,510,512,514,516,518,520,522,524,525, 527,529,531,533,535,537,539,541,543,545,547,549,551,553 25 and/or 555; c) a nucleic acid molecule whose sequence can be deduced from a polypeptide sequence encoded by a nucleic acid molecule of (a) or (b) as a result of the degeneracy of the genetic code; d) a nucleic acid molecule which encodes a polypeptide which has at least 30 80% identity with an amino acid sequence of a polypeptide encoded by a nucleic acid molecule of (a) to (c); e) a nucleic acid molecule, or complement thereof, which hybridises with a nucleic acid molecule of (a) to (c) under stringent hybridisation conditions ; 35 f) a nucleic acid molecule which encompasses a nucleic acid molecule which is obtained by amplifying nucleic acid molecules from a cDNA library or a genomic library using the primers in table 2 and conferring an altered metabolic activity in an organism or a part thereof; g) a nucleic acid molecule, or a complement thereof, encoding a polypeptide which is isolated with the aid of a monoclonal antibody 5 raised against a polypeptide encoded by one of the nucleic acid molecules of (a) to (f); and h) a nucleic acid molecule which is obtained by screening a suitable nucleic acid library under stringent hybridisation conditions with a probe comprising the sequence of a nucleic acid molecule of (a) to (g) or with a 10 fragment thereof having at least 15 nt, preferably 20 nt, 30 nt, 50 nt, 100 nt, 200 nt or 500 nt of a nucleic acid molecule characterised in (a) to (g).

9. An isolated nucleic acid construct when used to confer the expression of the isolated nucleic acid molecule according to claim 8, said construct comprising 15 one or more regulatory elements, whereby expression of said construct in a plant or plant cell results in an increased tolerance and/or resistance to environmental stress when compared to a wild type plant or plant cell.

10. A vector comprising the nucleic acid molecule as claimed in claim 8 or the 20 isolated nucleic acid construct of claim 9, whereby the expression of said vector in a plant or plant cell results in an increased tolerance and/or resistance to environmental stress when compared to a wild type plant or plant cell.

11. An isolated plant cell comprising an isolated nucleic acid molecule according to 25 claim 8, a nucleic acid construct according to claims 9 or a vector according to claim 10, whereby the expression of said isolated nucleic acid molecule, nucleic acid construct or vector in said plant cell results in an increased tolerance and/or resistance to environmental stress when compared to a wild type plant cell. 30

12. An isolated SRP which is encoded by SEQ ID NO: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 35 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, 196, 198, 200, 202, 204, 206, 208, 210, 212,214, 216, 218, 220, 222, 224, 226, 228, 230, 232, 234, 236, 238, 240, 242, 244,246, 248, 250, 252, 254, 256, 258, 260, 262, 264, 266, 268, 270, 272, 274, 276, 278, 280, 282, 284, 286, 288, 290, 292, 294, 296, 298, 300, 302, 304, 306, 308, 310, 313, 315, 317, 319, 321, 323, 325, 327, 329, 331, 333, 335, 337, 339, 341, 343, 345, 347, 349, 351, 353, 355, 357, 359, 361, 363, 365, 367, 369, 371, 373, 375, 377, 379, 381, 383, 385, 387, 389, 391, 5 393, 395, 397, 399, 401, 403, 405, 407, 409, 411, 413, 415, 417, 419, 421, 423, 425, 427, 429, 431, 433, 435, 437, 439, 441, 443, 445, 447, 449, 451, 453, 455, 457, 459, 461, 463, 465, 467, 469, 471, 473, 475, 477, 479, 481, 483, 485, 487, 489, 491, 493, 495, 497, 499, 501, 503, 505, 507, 509, 511, 513, 515, 517, 519, 521, 523, 526, 528, 530, 532, 534, 536, 538, 540, 542, 544, 546, 548, 550, 552, 10 554 and/or 556, and/or homologs thereof, when used to increase tolerance and/or resistance to environmental stress in a plant or plant cell when compared to a wild type plant or plant cell.

13. Use of an isolated nucleic acid molecule according to claim 8, a nucleic acid 15 construct according to claims 9, a vector according to claim 10 or SRP according to claim 12 in producing a plant or isolated plant cell having an increased tolerance and/or resistance to environmental stress when compared to said wild type plant or plant cell. 20

14. A method of modifying a plant or an isolated plant cell's tolerance and/or resistance to an environmental stress, said method comprising modifying the level of expression of an SRP coding nucleic acid molecule in the plant or isolated plant cell, said nucleic acid molecule selected from the group consisting of: 25 a) a nucleic acid molecule encoding a polypeptide shown in SEQ ID NO: 4, 6,8,10,12,14,16,18,20,22,24,26,28, 30,32, 34,36, 38,40,42,44, 46,48,50,52,54,56,58, 60,62, 64,66,68,70,72,74,76,78,80,82, 84,86,88,90, 92, 94,96, 98,100,102, 104, 106,108,110,112,114, 116, 118, 120,122,124,126,128,130,132,134,136,138,140,142, 30 144,146,148,150,152,154,156,158,160,162,164,166,168,170, 172, 174, 176, 178, 180,182,184,186, 188, 190, 192, 194, 196,198, 200,202,204,206,208,210,212,214,216,218,220,222,224,226, 228,230,232,234,236,238,240,242,244,246,248,250,252,254, 256,258,260,262,264,266,268,270,272,274,276,278,280,282, 35 284,286,288,290,292,294,296,298,300,302,304,306,308,310, 313, 315, 317, 319, 321,323,325,327, 329, 331, 333, 335, 337,339, 341, 343, 345, 347, 349,351,353,355, 357, 359, 361, 363, 365,367, 369, 371, 373, 375, 377,379,381,383, 385, 387, 389, 391, 393,395, 397, 399,401,403,405,407,409,411,413,415,417,419,421,423, 425,427,429,431,433,435,437,439,441,443,445,447,449,451, 453,455,457,459,461,463,465,467,469,471,473,475,477,479, 5 481,483,485,487,489,491,493,495,497,499,501,503,505,507, 509,511,513,515,517,519,521,523,526,528,530,532,534,536, 538, 540, 542, 544, 546, 548, 550, 552, 554 and/or 556, or a fragment thereof; b) a nucleic acid molecule comprising a nucleic acid molecule shown in 10 SEQ ID NO: 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37,39,41,43,45,47,49,51,53,55,57,59, 61,63, 65,67, 69,71,73, 75,77,79,81,83,85,87,89,91, 93,95,97, 99,101, 103, 105, 107, 109, 111, 113,115,117,119,121,123,125,127,129,131,133,135, 137, 139, 141,143,145,147,149,151,153,155,157,159,161,163, 15 165,167,169,171,173,175,177,179,181,183,185,187,189,191, 193,195,197,199,201,203,205,207,209,211,213,215,217,219, 221,223,225,227,229,231,233,235,237,239,241,243,245,247, 249,251,253,255,257,259,261,263,265,267,269,271,273,275, 277,279,281,283,285,287,289,291,293,295,297,299, 301,303, 20 305, 307, 309, 311, 312,314,316,318, 320, 322, 324, 326, 328,330, 332, 334, 336, 338, 340,342,344,346, 348, 350, 352, 354, 356,358, 360, 362, 364, 366, 368,370,372,374, 376, 378, 380, 382, 384,386, 388, 390, 392, 394, 396,398,400,402,404,406,408,410,412,414, 416,418,420,422,424,426,428,430,432,434,436,438,440,442, 25 444,446,448,450,452,454,456,458,460,462,464,466,468,470, 472,474,476,478,480,482,484,486,488,490,492,494,496,498, 500,502,504,506,508,510,512,514,516,518,520,522,524,525, 527,529,531,533,535,537,539,541,543,545,547,549,551,553 and/or 555; 30 c) a nucleic acid molecule whose sequence can be deduced from a polypeptide sequence encoded by a nucleic acid molecule of (a) or (b) as a result of the degeneracy of the genetic code; d) a nucleic acid molecule which encodes a polypeptide which has at least 80% identity with an amino acid sequence of a polypeptide encoded by a 35 nucleic acid molecule of (a) to (c); e) a nucleic acid molecule, or complement thereof, which hybridises with a nucleic acid molecule of (a) to (c) under stringent hybridisation conditions ; f) a nucleic acid molecule which encompasses a nucleic acid molecule 5 which is obtained by amplifying nucleic acid molecules from a cDNA library or a genomic library using the primers in table 2 and conferring an altered metabolic activity in an organism or a part thereof; g) a nucleic acid molecule, or a complement thereof, encoding a polypeptide which is isolated with the aid of a monoclonal antibody 10 raised against a polypeptide encoded by one of the nucleic acid molecules of (a) to (f); and h) a nucleic acid molecule which is obtained by screening a suitable nucleic acid library under stringent hybridisation conditions with a probe comprising the sequence of a nucleic acid molecule of (a) to (g) or with a 15 fragment thereof having at least 15 nt, preferably 20 nt, 30 nt, 50 nt, 100 nt, 200 nt or 500 nt of a nucleic acid molecule characterised in (a) to (g).

15. The method of claim 14,wherein a nucleic acid construct according to claim 9 or a vector according to claim 10 is used. 20

16. The method of 14, wherein the stress tolerance is increased.

17. Use of a SRP encoding nucleic acid as shown in SEQ ID NO: 1, and/or homologs or parts thereof, as markers for selecting plants or isolated plant cells with 25 increased tolerance to environmental stress.

18. Use of a SRP encoding nucleic acid as shown in SEQ ID NO: 1, and/or homologs or parts thereof, as markers for detecting stress in plants or isolated plant cells. 30

19. A plant comprising an isolated plant cell according to claim 11, wherein said plant overexpresses a SRP coding nucleic acid resulting in an increased tolerance and/or resistance to environmental stress when compared to said wild type plant.

20. An isolated plant cell according to any one of claims 1 to 3 or 11, a plant according to claim 4 or 5, a seed according to claim 6, an agricultural product according to claim 7, an isolated nucleic acid molecule according to claim 8, an 5 isolated nucleic acid construct according to claim 9, a vector according to claim 10, the use according to any one of claims 13, 17 or 18, a method according to any one of claims 14 to 16, substantially as hereinbefore described. 10 BASF PLANT SCIENCE GMBH WATERMARK PATENT & TRADE MARK ATTORNEYS 15 P26155AU00 20051006 e pf54437-SEQUENCES LISTING 949788.txt SEQUENCES <110> BASF PLANT SCIENCE <120> Nucleic acid sequences encoding proteins associated with abiotic stress response and plant cells and plants with increased tolerance to environmental stress <130> PF 54437 <140> PCT/US2004/011888 <141> CCYY MM DD <160> 850 <170> Biomax PatentTool according to PatentIN 3.1 format and PatentIN 3.1 <210> 1 <211> 1143 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1143) <400> 1 atg gat gga gcc aaa ttt gaa aat act gta gct ttt tta cca tct gaa 48 Met Asp Gly Ala Lys Phe Glu Asn Thr Val Ala Phe Leu Pro Ser Glu 1 5 10 15 ata ttt gat tgc tac aat tcc acg cta ccc aag aat gta ttc cga agt 96 Ile Phe Asp Cys Tyr Asn Ser Thr Leu Pro Lys Asn Val Phe Arg Ser 20 25 30 ttt gtt acc tgg tcc tgc tat gag aaa ttc aat tcc tta gaa ttc cgc 144 Phe Val Thr Trp Ser Cys Tyr Glu Lys Phe Asn Ser Leu Glu Phe Arg 35 40 45 act tgg cta tta atg tgg tta cca ctc att att gcg tgg aaa ata cgt 192 Thr Trp Leu Leu Met Trp Leu Pro Leu Ile Ile Ala Trp Lys Ile Arg 50 55 60 ggt aaa aga cac tat ctc gtt atc gtt act gct ctt atg ttt gaa gtg 240 Gly Lys Arg His Tyr Leu Val Ile Val Thr Ala Leu Met Phe Glu Val 65 70 75 80 ctg tat ttc tta tgg aca tat tcg tac ata ttc cga gaa cgc acc tta 288 Leu Tyr Phe Leu Trp Thr Tyr Ser Tyr Ile Phe Arg Glu Arg Thr Leu 85 90 95 gga aag caa gtt tct caa ttt gct aaa gag atc att aca aat act ccg 336 Gly Lys Gln Val Ser Gln Phe Ala Lys Glu Ile Ile Thr Asn Thr Pro 100 105 110 ggt ata gac act gaa gac tgg gaa cgt gtt gca gta aat ttc aat tct 384 Gly Ile Asp Thr Glu Asp Trp Glu Arg Val Ala Val Asn Phe Asn Ser 115 120 125 tat tta tat gaa aat aaa ctt tgg aat act gag tac ttt ttt ttt gat 432 Tyr Leu Tyr Glu Asn Lys Leu Trp Asn Thr Glu Tyr Phe Phe Phe Asp 130 135 140 Page 1 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggt tcc agc tgc caa gaa gcg ttc aga aag atg ctt ctt gag cca ttt 480 Gly Ser Ser Cys Gln Glu Ala Phe Arg Lys Met Leu Leu Glu Pro Phe 145 150 155 160 tcc ttg aaa aaa aat gac ttt gct aat gcc aag gta cct gac gga tct 528 Ser Leu Lys Lys Asn Asp Phe Ala Asn Ala Lys Val Pro Asp Gly Ser 165 170 175 gtt tgt tac act gaa aaa gct ttg cag gtt tat ttt aca cag ata gag 576 Val Cys Tyr Thr Glu Lys Ala Leu Gln Val Tyr Phe Thr Gln Ile Glu 180 185 190 aga aaa tgg cac tgg att aat tct gaa gga ttt tta cac aat aaa acc 624 Arg Lys Trp His Trp Ile Asn Ser Glu Gly Phe Leu His Asn Lys Thr 195 200 205 aca cag agt gtt caa ttt tcg aaa cat ggt tac ggt tcc aaa ctt ctc 672 Thr Gln Ser Val Gln Phe Ser Lys His Gly Tyr Gly Ser Lys Leu Leu 210 215 220 tgg gct ttc aag gaa gtg aca ata atg aat tca cgc ttt gcg ttc ttc 720 Trp Ala Phe Lys Glu Val Thr Ile Met Asn Ser Arg Phe Ala Phe Phe 225 230 235 240 agt att gct tac tta aac ggt ctc ctt act ata cca aga cta aga aat 768 Ser Ile Ala Tyr Leu Asn Gly Leu Leu Thr Ile Pro Arg Leu Arg Asn 245 250 255 tca ctg cat atc ctc tat gta tgt gca gtt ctt tca tct atg ata att 816 Ser Leu His Ile Leu Tyr Val Cys Ala Val Leu Ser Ser Met Ile Ile 260 265 270 gaa tat tta ata ggg atc gac aaa ttc agg ttc aaa tca atg aat ctg 864 Glu Tyr Leu Ile Gly Ile Asp Lys Phe Arg Phe Lys Ser Met Asn Leu 275 280 285 ata cat aaa cta cag ttc ttg tca tat att aca tgt gga cac gag aag 912 Ile His Lys Leu Gln Phe Leu Ser Tyr Ile Thr Cys Gly His Glu Lys 290 295 300 tct gat gca act aat tgg tct caa att gcg aag agg acg aat act tac 960 Ser Asp Ala Thr Asn Trp Ser Gln Ile Ala Lys Arg Thr Asn Thr Tyr 305 310 315 320 atg ttt gag cag aaa att tgg aat tcg cca ata ctg ttc tca gat ggt 1008 Met Phe Glu Gln Lys Ile Trp Asn Ser Pro Ile Leu Phe Ser Asp Gly 325 330 335 att gat tgt gaa aag ttt ttt aaa tgg tat ttc agt acc cct gta tct 1056 Ile Asp Cys Glu Lys Phe Phe Lys Trp Tyr Phe Ser Thr Pro Val Ser 340 345 350 tcg caa gcg tct ttg tca gtt ggt tcc act gat ttt gaa ctc tgg cca 1104 Ser Gln Ala Ser Leu Ser Val Gly Ser Thr Asp Phe Glu Leu Trp Pro 355 360 365 tat ata aaa gaa gca caa tca gct tgc aat gat gtg taa 1143 Tyr Ile Lys Glu Ala Gln Ser Ala Cys Asn Asp Val 370 375 380 <210> 2 <211> 380 <212> PRT <213> Saccharomyces cerevisiae <400> 2 Page 2 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Asp Gly Ala Lys Phe Glu Asn Thr Val Ala Phe Leu Pro Ser Glu 1 5 10 15 Ile Phe Asp Cys Tyr Asn Ser Thr Leu Pro Lys Asn Val Phe Arg Ser 20 25 30 Phe Val Thr Trp Ser Cys Tyr Glu Lys Phe Asn Ser Leu Glu Phe Arg 35 40 45 Thr Trp Leu Leu Met Trp Leu Pro Leu Ile Ile Ala Trp Lys Ile Arg 50 55 60 Gly Lys Arg His Tyr Leu Val Ile Val Thr Ala Leu Met Phe Glu Val 65 70 75 80 Leu Tyr Phe Leu Trp Thr Tyr Ser Tyr Ile Phe Arg Glu Arg Thr Leu 85 90 95 Gly Lys Gln Val Ser Gln Phe Ala Lys Glu Ile Ile Thr Asn Thr Pro 100 105 110 Gly Ile Asp Thr Glu Asp Trp Glu Arg Val Ala Val Asn Phe Asn Ser 115 120 125 Tyr Leu Tyr Glu Asn Lys Leu Trp Asn Thr Glu Tyr Phe Phe Phe Asp 130 135 140 Gly Ser Ser Cys Gln Glu Ala Phe Arg Lys Met Leu Leu Glu Pro Phe 145 150 155 160 Ser Leu Lys Lys Asn Asp Phe Ala Asn Ala Lys Val Pro Asp Gly Ser 165 170 175 Val Cys Tyr Thr Glu Lys Ala Leu Gln Val Tyr Phe Thr Gln Ile Glu 180 185 190 Arg Lys Trp His Trp Ile Asn Ser Glu Gly Phe Leu His Asn Lys Thr 195 200 205 Thr Gln Ser Val Gln Phe Ser Lys His Gly Tyr Gly Ser Lys Leu Leu 210 215 220 Trp Ala Phe Lys Glu Val Thr Ile Met Asn Ser Arg Phe Ala Phe Phe 225 230 235 240 Ser Ile Ala Tyr Leu Asn Gly Leu Leu Thr Ile Pro Arg Leu Arg Asn 245 250 255 Ser Leu His Ile Leu Tyr Val Cys Ala Val Leu Ser Ser Met Ile Ile 260 265 270 Glu Tyr Leu Ile Gly Ile Asp Lys Phe Arg Phe Lys Ser Met Asn Leu 275 280 285 Ile His Lys Leu Gln Phe Leu Ser Tyr Ile Thr Cys Gly His Glu Lys 290 295 300 Ser Asp Ala Thr Asn Trp Ser Gln Ile Ala Lys Arg Thr Asn Thr Tyr 305 310 315 320 Met Phe Glu Gln Lys Ile Trp Asn Ser Pro Ile Leu Phe Ser Asp Gly 325 330 335 Ile Asp Cys Glu Lys Phe Phe Lys Trp Tyr Phe Ser Thr Pro Val Ser 340 345 350 Ser Gln Ala Ser Leu Ser Val Gly Ser Thr Asp Phe Glu Leu Trp Pro 355 360 365 Page 3 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Tyr Ile Lys Glu Ala Gln Ser Ala Cys Asn Asp Val 370 375 380 <210> 3 <211> 1389 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1389) <400> 3 atg agc gaa ata aat aat gaa aat cta gag cca acc tca agt aca gta 48 Met Ser Glu Ile Asn Asn Glu Asn Leu Glu Pro Thr Ser Ser Thr Val 1 5 10 15 gct gag tct aca gaa agc aag aat aaa cac att cgt agc gct tta aga 96 Ala Glu Ser Thr Glu Ser Lys Asn Lys His Ile Arg Ser Ala Leu Arg 20 25 30 aaa cga aga ggt aaa tta agc gcc caa act tat gag gaa gat caa gag 144 Lys Arg Arg Gly Lys Leu Ser Ala Gln Thr Tyr Glu Glu Asp Gln Glu 35 40 45 gct att tta tca tct cct tta ttg act tca aca cct aaa aca gtc tcc 192 Ala Ile Leu Ser Ser Pro Leu Leu Thr Ser Thr Pro Lys Thr Val Ser 50 55 60 agg tca tta gtg agg tta tac cca tat tta att gtt gtg gat aac ttt 240 Arg Ser Leu Val Arg Leu Tyr Pro Tyr Leu Ile Val Val Asp Asn Phe 65 70 75 80 cta agt atc atc act tgg tcc aat gac aat gtc tct gca aac ttg ctt 288 Leu Ser Ile Ile Thr Trp Ser Asn Asp Asn Val Ser Ala Asn Leu Leu 85 90 95 gga ata ttc tta ttt acg gtt tgt gtt cta tat ttt gga ttt att aca 336 Gly Ile Phe Leu Phe Thr Val Cys Val Leu Tyr Phe Gly Phe Ile Thr 100 105 110 agg tat ttt gga cat tta atg atc gtt ggt ata ata tgg gta tat ctt 384 Arg Tyr Phe Gly His Leu Met Ile Val Gly Ile Ile Trp Val Tyr Leu 115 120 125 tta att gac aag cac gtt caa gaa aca atg gca tct tgc cct tca ttg 432 Leu Ile Asp Lys His Val Gln Glu Thr Met Ala Ser Cys Pro Ser Leu 130 135 140 gat gat ata ata cac gtt atg gat agg gtt tct atg aaa tct agc gct 480 Asp Asp Ile Ile His Val Met Asp Arg Val Ser Met Lys Ser Ser Ala 145 150 155 160 gtg tta tct cct att acg att ttg agc gct cag gat gtt aga aga ctg 528 Val Leu Ser Pro Ile Thr Ile Leu Ser Ala Gln Asp Val Arg Arg Leu 165 170 175 tta ttt acc att gcc ttc cta tcc cca gtt tat att ttt cta aca gtg 576 Leu Phe Thr Ile Ala Phe Leu Ser Pro Val Tyr Ile Phe Leu Thr Val 180 185 190 ttt gtg cta tct cca aac tat tta atg tta ata ggg ggt ctg tat gtg 624 Phe Val Leu Ser Pro Asn Tyr Leu Met Leu Ile Gly Gly Leu Tyr Val 195 200 205 Page 4 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ctt acg tac cat tct aaa cta atc cga aga atg aga aga tac ttg tgg 672 Leu Thr Tyr His Ser Lys Leu Ile Arg Arg Met Arg Arg Tyr Leu Trp 210 215 220 aaa ttt cgc gtt gtt aga tta ctt gta ttt ttc ata aca gga tta gac 720 Lys Phe Arg Val Val Arg Leu Leu Val Phe Phe Ile Thr Gly Leu Asp 225 230 235 240 ctt ggt gga cca gat aat aat agg cgc ttg ttt gct tct gtc aat aag 768 Leu Gly Gly Pro Asp Asn Asn Arg Arg Leu Phe Ala Ser Val Asn Lys 245 250 255 aaa ata agg tcc ttt gtt tgg aat gag gta ggg aac aca tct aac act 816 Lys Ile Arg Ser Phe Val Trp Asn Glu Val Gly Asn Thr Ser Asn Thr 260 265 270 aaa aag act gta ctt ttc aag gtt gct ctg ttt gaa aac cag cgc cgc 864 Lys Lys Thr Val Leu Phe Lys Val Ala Leu Phe Glu Asn Gln Arg Arg 275 280 285 tgg ctt ggc atc gga tgg aca tca act atg ttg agt tat gag cgc gca 912 Trp Leu Gly Ile Gly Trp Thr Ser Thr Met Leu Ser Tyr Glu Arg Ala 290 295 300 tct tgg aca gat gaa ttc cta aat act tct cca agc cca gaa gtg ttt 960 Ser Trp Thr Asp Glu Phe Leu Asn Thr Ser Pro Ser Pro Glu Val Phe 305 310 315 320 act tta cca gag gag cag tcg gga atg gct tgg gaa tgg cac gat aaa 1008 Thr Leu Pro Glu Glu Gln Ser Gly Met Ala Trp Glu Trp His Asp Lys 325 330 335 gat tgg atg ctt gac cta aca aat gat ggg atc att caa ctt cct gct 1056 Asp Trp Met Leu Asp Leu Thr Asn Asp Gly Ile Ile Gln Leu Pro Ala 340 345 350 tct gct gct aag aca aaa gtt aag cca ggt gca gat gaa ggt ttc ata 1104 Ser Ala Ala Lys Thr Lys Val Lys Pro Gly Ala Asp Glu Gly Phe Ile 355 360 365 tat tat gat aac acc tgg aat aat ccc tct gca acg gac aca tat aaa 1152 Tyr Tyr Asp Asn Thr Trp Asn Asn Pro Ser Ala Thr Asp Thr Tyr Lys 370 375 380 aag tac aca aga aga agg agg tgg atc agg act gca aca gta aca aca 1200 Lys Tyr Thr Arg Arg Arg Arg Trp Ile Arg Thr Ala Thr Val Thr Thr 385 390 395 400 acg tat gac gat gag ccc act gta gaa aaa gct aca ccg aat tct cat 1248 Thr Tyr Asp Asp Glu Pro Thr Val Glu Lys Ala Thr Pro Asn Ser His 405 410 415 gct ctg aag agt gaa gaa aat aat aga gtt aga aaa aga aaa gtg tca 1296 Ala Leu Lys Ser Glu Glu Asn Asn Arg Val Arg Lys Arg Lys Val Ser 420 425 430 ttt agt aca gca aat gaa gtg cat atc ata cct tcc tcg gac agt agc 1344 Phe Ser Thr Ala Asn Glu Val His Ile Ile Pro Ser Ser Asp Ser Ser 435 440 445 aaa tta ata caa ata tct gat gtt tca atg tct cct tct cta taa 1389 Lys Leu Ile Gln Ile Ser Asp Val Ser Met Ser Pro Ser Leu 450 455 460 <210> 4 <211> 462 <212> PRT Page 5 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Saccharomyces cerevisiae <400> 4 Met Ser Glu Ile Asn Asn Glu Asn Leu Glu Pro Thr Ser Ser Thr Val 1 5 10 15 Ala Glu Ser Thr Glu Ser Lys Asn Lys His Ile Arg Ser Ala Leu Arg 20 25 30 Lys Arg Arg Gly Lys Leu Ser Ala Gln Thr Tyr Glu Glu Asp Gln Glu 35 40 45 Ala Ile Leu Ser Ser Pro Leu Leu Thr Ser Thr Pro Lys Thr Val Ser 50 55 60 Arg Ser Leu Val Arg Leu Tyr Pro Tyr Leu Ile Val Val Asp Asn Phe 65 70 75 80 Leu Ser Ile Ile Thr Trp Ser Asn Asp Asn Val Ser Ala Asn Leu Leu 85 90 95 Gly Ile Phe Leu Phe Thr Val Cys Val Leu Tyr Phe Gly Phe Ile Thr 100 105 110 Arg Tyr Phe Gly His Leu Met Ile Val Gly Ile Ile Trp Val Tyr Leu 115 120 125 Leu Ile Asp Lys His Val Gln Glu Thr Met Ala Ser Cys Pro Ser Leu 130 135 140 Asp Asp Ile Ile His Val Met Asp Arg Val Ser Met Lys Ser Ser Ala 145 150 155 160 Val Leu Ser Pro Ile Thr Ile Leu Ser Ala Gln Asp Val Arg Arg Leu 165 170 175 Leu Phe Thr Ile Ala Phe Leu Ser Pro Val Tyr Ile Phe Leu Thr Val 180 185 190 Phe Val Leu Ser Pro Asn Tyr Leu Met Leu Ile Gly Gly Leu Tyr Val 195 200 205 Leu Thr Tyr His Ser Lys Leu Ile Arg Arg Met Arg Arg Tyr Leu Trp 210 215 220 Lys Phe Arg Val Val Arg Leu Leu Val Phe Phe Ile Thr Gly Leu Asp 225 230 235 240 Leu Gly Gly Pro Asp Asn Asn Arg Arg Leu Phe Ala Ser Val Asn Lys 245 250 255 Lys Ile Arg Ser Phe Val Trp Asn Glu Val Gly Asn Thr Ser Asn Thr 260 265 270 Lys Lys Thr Val Leu Phe Lys Val Ala Leu Phe Glu Asn Gln Arg Arg 275 280 285 Trp Leu Gly Ile Gly Trp Thr Ser Thr Met Leu Ser Tyr Glu Arg Ala 290 295 300 Ser Trp Thr Asp Glu Phe Leu Asn Thr Ser Pro Ser Pro Glu Val Phe 305 310 315 320 Thr Leu Pro Glu Glu Gln Ser Gly Met Ala Trp Glu Trp His Asp Lys 325 330 335 Asp Trp Met Leu Asp Leu Thr Asn Asp Gly Ile Ile Gln Leu Pro Ala Page 6 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 340 345 350 Ser Ala Ala Lys Thr Lys Val Lys Pro Gly Ala Asp Glu Gly Phe Ile 355 360 365 Tyr Tyr Asp Asn Thr Trp Asn Asn Pro Ser Ala Thr Asp Thr Tyr Lys 370 375 380 Lys Tyr Thr Arg Arg Arg Arg Trp Ile Arg Thr Ala Thr Val Thr Thr 385 390 395 400 Thr Tyr Asp Asp Glu Pro Thr Val Glu Lys Ala Thr Pro Asn Ser His 405 410 415 Ala Leu Lys Ser Glu Glu Asn Asn Arg Val Arg Lys Arg Lys Val Ser 420 425 430 Phe Ser Thr Ala Asn Glu Val His Ile Ile Pro Ser Ser Asp Ser Ser 435 440 445 Lys Leu Ile Gln Ile Ser Asp Val Ser Met Ser Pro Ser Leu 450 455 460 <210> 5 <211> 3921 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(3921) <400> 5 atg cag ttt cca ttc gct tgt ctc cta tcg acc ctt gta att agt ggg 48 Met Gln Phe Pro Phe Ala Cys Leu Leu Ser Thr Leu Val Ile Ser Gly 1 5 10 15 tca ttg gcc cgg gcc agc ccc ttc gac ttt ata ttc ggc aat gga acg 96 Ser Leu Ala Arg Ala Ser Pro Phe Asp Phe Ile Phe Gly Asn Gly Thr 20 25 30 caa caa gct cag agc caa agc gag agt caa ggt caa gtt tct ttc acc 144 Gln Gln Ala Gln Ser Gln Ser Glu Ser Gln Gly Gln Val Ser Phe Thr 35 40 45 aat gaa gct tct cag gat agt tcc acc acc tct ttg gta aca gcc tat 192 Asn Glu Ala Ser Gln Asp Ser Ser Thr Thr Ser Leu Val Thr Ala Tyr 50 55 60 tct caa ggt gtt cat tcg cac cag tct gca aca ata gtg agt gcc aca 240 Ser Gln Gly Val His Ser His Gln Ser Ala Thr Ile Val Ser Ala Thr 65 70 75 80 atc tct tcc ctc cca tct act tgg tat gat gcg agc tcc act tcc cag 288 Ile Ser Ser Leu Pro Ser Thr Trp Tyr Asp Ala Ser Ser Thr Ser Gln 85 90 95 act tct gtg tca tat gcc agt caa gaa tcc gac tat gcc gtt aat caa 336 Thr Ser Val Ser Tyr Ala Ser Gln Glu Ser Asp Tyr Ala Val Asn Gln 100 105 110 aac tct tgg agc gcg tct act aat caa ctg cca tct acc agt acg aca 384 Asn Ser Trp Ser Ala Ser Thr Asn Gln Leu Pro Ser Thr Ser Thr Thr 115 120 125 agc tac tat gcg cca acc ttc agt aca tcg gcc gat ttt gct gct tct 432 Page 7 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Tyr Tyr Ala Pro Thr Phe Ser Thr Ser Ala Asp Phe Ala Ala Ser 130 135 140 agt gta aat gca gct tct gat gtc tcc act gcc agt gtt ccc att gat 480 Ser Val Asn Ala Ala Ser Asp Val Ser Thr Ala Ser Val Pro Ile Asp 145 150 155 160 acg agt gct aat tct atc cct ttc aca act aca agt aac ata gag act 528 Thr Ser Ala Asn Ser Ile Pro Phe Thr Thr Thr Ser Asn Ile Glu Thr 165 170 175 aca acg agt gca cct ctc act tcg gac act cca ctt att tcc act agt 576 Thr Thr Ser Ala Pro Leu Thr Ser Asp Thr Pro Leu Ile Ser Thr Ser 180 185 190 acg atg tcc gca gct gat aac gta ttt tcg tca gca aac cct att tct 624 Thr Met Ser Ala Ala Asp Asn Val Phe Ser Ser Ala Asn Pro Ile Ser 195 200 205 gcc tcc cta aca acc acc gat agt tca gaa agt ttt gac caa act tcg 672 Ala Ser Leu Thr Thr Thr Asp Ser Ser Glu Ser Phe Asp Gln Thr Ser 210 215 220 act gct ggt gcc att ccg gtg caa agt tca gca gat ttt agt agt tct 720 Thr Ala Gly Ala Ile Pro Val Gln Ser Ser Ala Asp Phe Ser Ser Ser 225 230 235 240 agt gaa att tta gta caa agt tcg gcg gat ttc agt agc cct agt tct 768 Ser Glu Ile Leu Val Gln Ser Ser Ala Asp Phe Ser Ser Pro Ser Ser 245 250 255 cca act act acc gat ata tcg cta tca gct gcc cca ctg caa aca agt 816 Pro Thr Thr Thr Asp Ile Ser Leu Ser Ala Ala Pro Leu Gln Thr Ser 260 265 270 gaa tca agc agt ttt acc act gca tca gca gct cta cca gta agt tca 864 Glu Ser Ser Ser Phe Thr Thr Ala Ser Ala Ala Leu Pro Val Ser Ser 275 280 285 aca gac gtt gat ggc tca agc gcc tca cct gta gtg agc atg agc gcc 912 Thr Asp Val Asp Gly Ser Ser Ala Ser Pro Val Val Ser Met Ser Ala 290 295 300 gca gga caa ata gct agc tca agc agc aca gat aat cca act atg tca 960 Ala Gly Gln Ile Ala Ser Ser Ser Ser Thr Asp Asn Pro Thr Met Ser 305 310 315 320 gaa acc ttt tcg tta aca tct aca gaa gtt gat ggt tcc gat gtt tca 1008 Glu Thr Phe Ser Leu Thr Ser Thr Glu Val Asp Gly Ser Asp Val Ser 325 330 335 tca aca gtg agc gca tta tta tcg gct cct ttt tta caa aca agt act 1056 Ser Thr Val Ser Ala Leu Leu Ser Ala Pro Phe Leu Gln Thr Ser Thr 340 345 350 tcc aac agt ttc agc att gtt agc cca tcg gta tct ttt gtt cca tca 1104 Ser Asn Ser Phe Ser Ile Val Ser Pro Ser Val Ser Phe Val Pro Ser 355 360 365 cag agt tcc tca gac gtt gct agc tcc agt act gca aat gta gtt agt 1152 Gln Ser Ser Ser Asp Val Ala Ser Ser Ser Thr Ala Asn Val Val Ser 370 375 380 tca tcc ttt tct gat att cca ccg caa act agt acc tca ggg agc gta 1200 Ser Ser Phe Ser Asp Ile Pro Pro Gln Thr Ser Thr Ser Gly Ser Val 385 390 395 400 gtt tcg gta gcg caa tcc gca tct gcc ctc gca ttt caa agt tca aca 1248 Page 8 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Ser Val Ala Gln Ser Ala Ser Ala Leu Ala Phe Gln Ser Ser Thr 405 410 415 gag gta tat ggt gcc agt gcc tcg agc aca atg agt tca tta tta tca 1296 Glu Val Tyr Gly Ala Ser Ala Ser Ser Thr Met Ser Ser Leu Leu Ser 420 425 430 act act tcg cta cag tct act act ttg gat agc tca agt tta gct agc 1344 Thr Thr Ser Leu Gln Ser Thr Thr Leu Asp Ser Ser Ser Leu Ala Ser 435 440 445 tcc tct gcg tcg agt tca gac ctt aca gat tat ggc gtc tcc agt aca 1392 Ser Ser Ala Ser Ser Ser Asp Leu Thr Asp Tyr Gly Val Ser Ser Thr 450 455 460 gca agc ata ccg ctg ttg tca gcc tca gaa caa gca agt act tcc agc 1440 Ala Ser Ile Pro Leu Leu Ser Ala Ser Glu Gln Ala Ser Thr Ser Ser 465 470 475 480 agt ttt agc gtt gtt agc cct tcg gta tct ttt gtt cca tca caa agt 1488 Ser Phe Ser Val Val Ser Pro Ser Val Ser Phe Val Pro Ser Gln Ser 485 490 495 tcc tca gat gtt gct agc acc agt gct cca agt gta gtt agt tca tcc 1536 Ser Ser Asp Val Ala Ser Thr Ser Ala Pro Ser Val Val Ser Ser Ser 500 505 510 ttt tct tat act tca ctg caa gca ggt ggc tct agc atg acc aat ccc 1584 Phe Ser Tyr Thr Ser Leu Gln Ala Gly Gly Ser Ser Met Thr Asn Pro 515 520 525 tct tca tca act ata gta tat tca agt agt act ggc agt tct gag gaa 1632 Ser Ser Ser Thr Ile Val Tyr Ser Ser Ser Thr Gly Ser Ser Glu Glu 530 535 540 tcc gct gca tct aca gct tct gca aca ctg tcg ggc tcc tcg tct act 1680 Ser Ala Ala Ser Thr Ala Ser Ala Thr Leu Ser Gly Ser Ser Ser Thr 545 550 555 560 tat atg gca gga aat ttg caa tca cag cct cca tcc act tca agt ttg 1728 Tyr Met Ala Gly Asn Leu Gln Ser Gln Pro Pro Ser Thr Ser Ser Leu 565 570 575 ctt tcg gag tct caa gct aca agc act tca gct gtg cta gct agc agt 1776 Leu Ser Glu Ser Gln Ala Thr Ser Thr Ser Ala Val Leu Ala Ser Ser 580 585 590 tct gtt tct aca act tca ccc tat acc act gca ggt ggt gca tct aca 1824 Ser Val Ser Thr Thr Ser Pro Tyr Thr Thr Ala Gly Gly Ala Ser Thr 595 600 605 gag gcc tca tcc ctc ata tca tct aca tct gcg gaa act tcc cag gta 1872 Glu Ala Ser Ser Leu Ile Ser Ser Thr Ser Ala Glu Thr Ser Gln Val 610 615 620 agt tat tca caa agc aca act gca ttg caa act tcc tca ttc gca tcg 1920 Ser Tyr Ser Gln Ser Thr Thr Ala Leu Gln Thr Ser Ser Phe Ala Ser 625 630 635 640 tct tca aca aca gaa gga agt gaa aca tct agt caa ggt ttt tct acc 1968 Ser Ser Thr Thr Glu Gly Ser Glu Thr Ser Ser Gln Gly Phe Ser Thr 645 650 655 agc tct gtt tta gtt caa atg cct tct tcg att tcc agc gaa ttc tca 2016 Ser Ser Val Leu Val Gln Met Pro Ser Ser Ile Ser Ser Glu Phe Ser 660 665 670 ccc tct cag acg aca act caa atg aat tct gca agc tca tca tct cag 2064 Page 9 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Ser Gln Thr Thr Thr Gln Met Asn Ser Ala Ser Ser Ser Ser Gln 675 680 685 tac act ata tca tcc act ggt ata ctt tct cag gtt tca gac aca tcg 2112 Tyr Thr Ile Ser Ser Thr Gly Ile Leu Ser Gln Val Ser Asp Thr Ser 690 695 700 gtg tct tat aca act tca agt tcg tct gtt tct caa gtt tca gac aca 2160 Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val Ser Asp Thr 705 710 715 720 cca gtt tct tat aca act tca agt tcg tct gtt tct caa gtt tca gac 2208 Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val Ser Asp 725 730 735 aca ccg gtt tct tat aca act tca agt tcg tct gtt tct caa gtt tca 2256 Thr Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val Ser 740 745 750 gac aca cca gtt tct tat aca act tca agt tca tct gtt tct caa gtt 2304 Asp Thr Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val 755 760 765 tca gac aca ccg gtt tct tat aca act tca agt tcg tcc gtt tct caa 2352 Ser Asp Thr Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln 770 775 780 gtt tca gac acg tca gta cct tct aca agt tcc aga tcg tcc gtt tct 2400 Val Ser Asp Thr Ser Val Pro Ser Thr Ser Ser Arg Ser Ser Val Ser 785 790 795 800 caa gtc tca gac act ccg gtg cct tct aca agt tca agg tcg tcc gtt 2448 Gln Val Ser Asp Thr Pro Val Pro Ser Thr Ser Ser Arg Ser Ser Val 805 810 815 tct caa aca tct agc tca cta cag ccc acc act aca tcc tcc caa cgt 2496 Ser Gln Thr Ser Ser Ser Leu Gln Pro Thr Thr Thr Ser Ser Gln Arg 820 825 830 ttc acc att tcc act cat gga gcg ctt tct gaa agt agt tct gtt agc 2544 Phe Thr Ile Ser Thr His Gly Ala Leu Ser Glu Ser Ser Ser Val Ser 835 840 845 caa caa gct tct gag att act agc tca atc aat gca aca gct tcc gaa 2592 Gln Gln Ala Ser Glu Ile Thr Ser Ser Ile Asn Ala Thr Ala Ser Glu 850 855 860 tac cat agc atc cag aca acc gcg gct act caa tcc aca act cta tct 2640 Tyr His Ser Ile Gln Thr Thr Ala Ala Thr Gln Ser Thr Thr Leu Ser 865 870 875 880 ttt acc gac gca aac agc agt tct gct tcc gct cca ttg gaa gtg gca 2688 Phe Thr Asp Ala Asn Ser Ser Ser Ala Ser Ala Pro Leu Glu Val Ala 885 890 895 acg tct acg cca acc cca tct tca aag gca tcc tct ctg ttg ctt aca 2736 Thr Ser Thr Pro Thr Pro Ser Ser Lys Ala Ser Ser Leu Leu Leu Thr 900 905 910 cca tca aca tcc tct tta agt cag gtt gct aca aat act aat gta cag 2784 Pro Ser Thr Ser Ser Leu Ser Gln Val Ala Thr Asn Thr Asn Val Gln 915 920 925 acg agt tta aca acg gaa tcg acg acc gtt tta gaa cca tca acg act 2832 Thr Ser Leu Thr Thr Glu Ser Thr Thr Val Leu Glu Pro Ser Thr Thr 930 935 940 aac agt tcc agt acg ttt agt ctg gtc act tca agt gac aac aat tgg 2880 Page 10 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Ser Ser Ser Thr Phe Ser Leu Val Thr Ser Ser Asp Asn Asn Trp 945 950 955 960 tgg att cca act gag tta atc acg cag gca cca gaa gct gca tcc act 2928 Trp Ile Pro Thr Glu Leu Ile Thr Gln Ala Pro Glu Ala Ala Ser Thr 965 970 975 gca tct tct acc gtt gga gga aca caa act atg act ttg ccc cat gca 2976 Ala Ser Ser Thr Val Gly Gly Thr Gln Thr Met Thr Leu Pro His Ala 980 985 990 att gca gcc gcg aca caa gtt ccc gag cct gag ggc tac acc cta atc 3024 Ile Ala Ala Ala Thr Gln Val Pro Glu Pro Glu Gly Tyr Thr Leu Ile 995 1000 1005 aca ata ggg ttc aaa aaa gct ttg aac tac gaa ttt gtt gta tca 3069 Thr Ile Gly Phe Lys Lys Ala Leu Asn Tyr Glu Phe Val Val Ser 1010 1015 1020 gaa cca aaa tca tcg gct caa atc ttc gga tac ttg cct gaa gct 3114 Glu Pro Lys Ser Ser Ala Gln Ile Phe Gly Tyr Leu Pro Glu Ala 1025 1030 1035 ctg aac aca cct ttt aag aac gta ttc aca aac att acg gta cta 3159 Leu Asn Thr Pro Phe Lys Asn Val Phe Thr Asn Ile Thr Val Leu 1040 1045 1050 caa ata gtg cca tta cag gat gac tca ctc aac tac tta gta agt 3204 Gln Ile Val Pro Leu Gln Asp Asp Ser Leu Asn Tyr Leu Val Ser 1055 1060 1065 gtt gct gaa gta tac ttt cca act gca gaa ata gag gag ctg tca 3249 Val Ala Glu Val Tyr Phe Pro Thr Ala Glu Ile Glu Glu Leu Ser 1070 1075 1080 aat cta att acc aac tct tca agc gct ttt tac acg gat gga atg 3294 Asn Leu Ile Thr Asn Ser Ser Ser Ala Phe Tyr Thr Asp Gly Met 1085 1090 1095 ggt aca gca aaa tct atg gct gca atg gtt gat tcc tca ata ccg 3339 Gly Thr Ala Lys Ser Met Ala Ala Met Val Asp Ser Ser Ile Pro 1100 1105 1110 cta acg ggc ctc tta cac gat agt aac agc aac tct ggc gga tct 3384 Leu Thr Gly Leu Leu His Asp Ser Asn Ser Asn Ser Gly Gly Ser 1115 1120 1125 tcg gac gga tcc tcc tcc agt aat tcg aac tca gga tct tca ggt 3429 Ser Asp Gly Ser Ser Ser Ser Asn Ser Asn Ser Gly Ser Ser Gly 1130 1135 1140 tca gga tct aat tcg aac tcc ggt gtg tct tca tct tcc gga aat 3474 Ser Gly Ser Asn Ser Asn Ser Gly Val Ser Ser Ser Ser Gly Asn 1145 1150 1155 tcc tat caa gat gcc ggt act ttg gaa tat tca tcc aaa tct aac 3519 Ser Tyr Gln Asp Ala Gly Thr Leu Glu Tyr Ser Ser Lys Ser Asn 1160 1165 1170 tcc aac gta tcc act tct agc aaa tca aag aaa aaa atc att ggt 3564 Ser Asn Val Ser Thr Ser Ser Lys Ser Lys Lys Lys Ile Ile Gly 1175 1180 1185 tta gtt atc ggc gtt gtt gtt ggt gga tgc tta tat att tta ttc 3609 Leu Val Ile Gly Val Val Val Gly Gly Cys Leu Tyr Ile Leu Phe 1190 1195 1200 atg att ttt gct ttc aag tat atc ata aga agg cgg att caa agt 3654 Page 11 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Ile Phe Ala Phe Lys Tyr Ile Ile Arg Arg Arg Ile Gln Ser 1205 1210 1215 caa gaa att atc aag aac cca gaa att tcc agt atc agt tca agt 3699 Gln Glu Ile Ile Lys Asn Pro Glu Ile Ser Ser Ile Ser Ser Ser 1220 1225 1230 gaa ttt ggt gga gag aaa aat tac aat aat gaa aag aga atg agc 3744 Glu Phe Gly Gly Glu Lys Asn Tyr Asn Asn Glu Lys Arg Met Ser 1235 1240 1245 gtt caa gaa tcc ata aca caa tct atg cga att caa aat tgg atg 3789 Val Gln Glu Ser Ile Thr Gln Ser Met Arg Ile Gln Asn Trp Met 1250 1255 1260 gat gat agt tac tat ggt cac ggg ttg aca aat aat gac tca act 3834 Asp Asp Ser Tyr Tyr Gly His Gly Leu Thr Asn Asn Asp Ser Thr 1265 1270 1275 cca acc agg cac aat aca tcg agt tcc ata cca aaa att tca aga 3879 Pro Thr Arg His Asn Thr Ser Ser Ser Ile Pro Lys Ile Ser Arg 1280 1285 1290 cca att gct agc caa aac tcc ctg ggt tgg aac gaa gtt tga 3921 Pro Ile Ala Ser Gln Asn Ser Leu Gly Trp Asn Glu Val 1295 1300 1305 <210> 6 <211> 1306 <212> PRT <213> Saccharomyces cerevisiae <400> 6 Met Gln Phe Pro Phe Ala Cys Leu Leu Ser Thr Leu Val Ile Ser Gly 1 5 10 15 Ser Leu Ala Arg Ala Ser Pro Phe Asp Phe Ile Phe Gly Asn Gly Thr 20 25 30 Gln Gln Ala Gln Ser Gln Ser Glu Ser Gln Gly Gln Val Ser Phe Thr 35 40 45 Asn Glu Ala Ser Gln Asp Ser Ser Thr Thr Ser Leu Val Thr Ala Tyr 50 55 60 Ser Gln Gly Val His Ser His Gln Ser Ala Thr Ile Val Ser Ala Thr 65 70 75 80 Ile Ser Ser Leu Pro Ser Thr Trp Tyr Asp Ala Ser Ser Thr Ser Gln 85 90 95 Thr Ser Val Ser Tyr Ala Ser Gln Glu Ser Asp Tyr Ala Val Asn Gln 100 105 110 Asn Ser Trp Ser Ala Ser Thr Asn Gln Leu Pro Ser Thr Ser Thr Thr 115 120 125 Ser Tyr Tyr Ala Pro Thr Phe Ser Thr Ser Ala Asp Phe Ala Ala Ser 130 135 140 Ser Val Asn Ala Ala Ser Asp Val Ser Thr Ala Ser Val Pro Ile Asp 145 150 155 160 Thr Ser Ala Asn Ser Ile Pro Phe Thr Thr Thr Ser Asn Ile Glu Thr 165 170 175 Page 12 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Thr Ser Ala Pro Leu Thr Ser Asp Thr Pro Leu Ile Ser Thr Ser 180 185 190 Thr Met Ser Ala Ala Asp Asn Val Phe Ser Ser Ala Asn Pro Ile Ser 195 200 205 Ala Ser Leu Thr Thr Thr Asp Ser Ser Glu Ser Phe Asp Gln Thr Ser 210 215 220 Thr Ala Gly Ala Ile Pro Val Gln Ser Ser Ala Asp Phe Ser Ser Ser 225 230 235 240 Ser Glu Ile Leu Val Gln Ser Ser Ala Asp Phe Ser Ser Pro Ser Ser 245 250 255 Pro Thr Thr Thr Asp Ile Ser Leu Ser Ala Ala Pro Leu Gln Thr Ser 260 265 270 Glu Ser Ser Ser Phe Thr Thr Ala Ser Ala Ala Leu Pro Val Ser Ser 275 280 285 Thr Asp Val Asp Gly Ser Ser Ala Ser Pro Val Val Ser Met Ser Ala 290 295 300 Ala Gly Gln Ile Ala Ser Ser Ser Ser Thr Asp Asn Pro Thr Met Ser 305 310 315 320 Glu Thr Phe Ser Leu Thr Ser Thr Glu Val Asp Gly Ser Asp Val Ser 325 330 335 Ser Thr Val Ser Ala Leu Leu Ser Ala Pro Phe Leu Gln Thr Ser Thr 340 345 350 Ser Asn Ser Phe Ser Ile Val Ser Pro Ser Val Ser Phe Val Pro Ser 355 360 365 Gln Ser Ser Ser Asp Val Ala Ser Ser Ser Thr Ala Asn Val Val Ser 370 375 380 Ser Ser Phe Ser Asp Ile Pro Pro Gln Thr Ser Thr Ser Gly Ser Val 385 390 395 400 Val Ser Val Ala Gln Ser Ala Ser Ala Leu Ala Phe Gln Ser Ser Thr 405 410 415 Glu Val Tyr Gly Ala Ser Ala Ser Ser Thr Met Ser Ser Leu Leu Ser 420 425 430 Thr Thr Ser Leu Gln Ser Thr Thr Leu Asp Ser Ser Ser Leu Ala Ser 435 440 445 Ser Ser Ala Ser Ser Ser Asp Leu Thr Asp Tyr Gly Val Ser Ser Thr 450 455 460 Ala Ser Ile Pro Leu Leu Ser Ala Ser Glu Gln Ala Ser Thr Ser Ser 465 470 475 480 Ser Phe Ser Val Val Ser Pro Ser Val Ser Phe Val Pro Ser Gln Ser 485 490 495 Ser Ser Asp Val Ala Ser Thr Ser Ala Pro Ser Val Val Ser Ser Ser 500 505 510 Phe Ser Tyr Thr Ser Leu Gln Ala Gly Gly Ser Ser Met Thr Asn Pro 515 520 525 Ser Ser Ser Thr Ile Val Tyr Ser Ser Ser Thr Gly Ser Ser Glu Glu 530 535 540 Page 13 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Ala Ala Ser Thr Ala Ser Ala Thr Leu Ser Gly Ser Ser Ser Thr 545 550 555 560 Tyr Met Ala Gly Asn Leu Gln Ser Gln Pro Pro Ser Thr Ser Ser Leu 565 570 575 Leu Ser Glu Ser Gln Ala Thr Ser Thr Ser Ala Val Leu Ala Ser Ser 580 585 590 Ser Val Ser Thr Thr Ser Pro Tyr Thr Thr Ala Gly Gly Ala Ser Thr 595 600 605 Glu Ala Ser Ser Leu Ile Ser Ser Thr Ser Ala Glu Thr Ser Gln Val 610 615 620 Ser Tyr Ser Gln Ser Thr Thr Ala Leu Gln Thr Ser Ser Phe Ala Ser 625 630 635 640 Ser Ser Thr Thr Glu Gly Ser Glu Thr Ser Ser Gln Gly Phe Ser Thr 645 650 655 Ser Ser Val Leu Val Gln Met Pro Ser Ser Ile Ser Ser Glu Phe Ser 660 665 670 Pro Ser Gln Thr Thr Thr Gln Met Asn Ser Ala Ser Ser Ser Ser Gln 675 680 685 Tyr Thr Ile Ser Ser Thr Gly Ile Leu Ser Gln Val Ser Asp Thr Ser 690 695 700 Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val Ser Asp Thr 705 710 715 720 Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val Ser Asp 725 730 735 Thr Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val Ser 740 745 750 Asp Thr Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln Val 755 760 765 Ser Asp Thr Pro Val Ser Tyr Thr Thr Ser Ser Ser Ser Val Ser Gln 770 775 780 Val Ser Asp Thr Ser Val Pro Ser Thr Ser Ser Arg Ser Ser Val Ser 785 790 795 800 Gln Val Ser Asp Thr Pro Val Pro Ser Thr Ser Ser Arg Ser Ser Val 805 810 815 Ser Gln Thr Ser Ser Ser Leu Gln Pro Thr Thr Thr Ser Ser Gln Arg 820 825 830 Phe Thr Ile Ser Thr His Gly Ala Leu Ser Glu Ser Ser Ser Val Ser 835 840 845 Gln Gln Ala Ser Glu Ile Thr Ser Ser Ile Asn Ala Thr Ala Ser Glu 850 855 860 Tyr His Ser Ile Gln Thr Thr Ala Ala Thr Gln Ser Thr Thr Leu Ser 865 870 875 880 Phe Thr Asp Ala Asn Ser Ser Ser Ala Ser Ala Pro Leu Glu Val Ala 885 890 895 Thr Ser Thr Pro Thr Pro Ser Ser Lys Ala Ser Ser Leu Leu Leu Thr Page 14 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 900 905 910 Pro Ser Thr Ser Ser Leu Ser Gln Val Ala Thr Asn Thr Asn Val Gln 915 920 925 Thr Ser Leu Thr Thr Glu Ser Thr Thr Val Leu Glu Pro Ser Thr Thr 930 935 940 Asn Ser Ser Ser Thr Phe Ser Leu Val Thr Ser Ser Asp Asn Asn Trp 945 950 955 960 Trp Ile Pro Thr Glu Leu Ile Thr Gln Ala Pro Glu Ala Ala Ser Thr 965 970 975 Ala Ser Ser Thr Val Gly Gly Thr Gln Thr Met Thr Leu Pro His Ala 980 985 990 Ile Ala Ala Ala Thr Gln Val Pro Glu Pro Glu Gly Tyr Thr Leu Ile 995 1000 1005 Thr Ile Gly Phe Lys Lys Ala Leu Asn Tyr Glu Phe Val Val Ser 1010 1015 1020 Glu Pro Lys Ser Ser Ala Gln Ile Phe Gly Tyr Leu Pro Glu Ala 1025 1030 1035 Leu Asn Thr Pro Phe Lys Asn Val Phe Thr Asn Ile Thr Val Leu 1040 1045 1050 Gln Ile Val Pro Leu Gln Asp Asp Ser Leu Asn Tyr Leu Val Ser 1055 1060 1065 Val Ala Glu Val Tyr Phe Pro Thr Ala Glu Ile Glu Glu Leu Ser 1070 1075 1080 Asn Leu Ile Thr Asn Ser Ser Ser Ala Phe Tyr Thr Asp Gly Met 1085 1090 1095 Gly Thr Ala Lys Ser Met Ala Ala Met Val Asp Ser Ser Ile Pro 1100 1105 1110 Leu Thr Gly Leu Leu His Asp Ser Asn Ser Asn Ser Gly Gly Ser 1115 1120 1125 Ser Asp Gly Ser Ser Ser Ser Asn Ser Asn Ser Gly Ser Ser Gly 1130 1135 1140 Ser Gly Ser Asn Ser Asn Ser Gly Val Ser Ser Ser Ser Gly Asn 1145 1150 1155 Ser Tyr Gln Asp Ala Gly Thr Leu Glu Tyr Ser Ser Lys Ser Asn 1160 1165 1170 Ser Asn Val Ser Thr Ser Ser Lys Ser Lys Lys Lys Ile Ile Gly 1175 1180 1185 Leu Val Ile Gly Val Val Val Gly Gly Cys Leu Tyr Ile Leu Phe 1190 1195 1200 Met Ile Phe Ala Phe Lys Tyr Ile Ile Arg Arg Arg Ile Gln Ser 1205 1210 1215 Gln Glu Ile Ile Lys Asn Pro Glu Ile Ser Ser Ile Ser Ser Ser 1220 1225 1230 Glu Phe Gly Gly Glu Lys Asn Tyr Asn Asn Glu Lys Arg Met Ser 1235 1240 1245 Page 15 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Gln Glu Ser Ile Thr Gln Ser Met Arg Ile Gln Asn Trp Met 1250 1255 1260 Asp Asp Ser Tyr Tyr Gly His Gly Leu Thr Asn Asn Asp Ser Thr 1265 1270 1275 Pro Thr Arg His Asn Thr Ser Ser Ser Ile Pro Lys Ile Ser Arg 1280 1285 1290 Pro Ile Ala Ser Gln Asn Ser Leu Gly Trp Asn Glu Val 1295 1300 1305 <210> 7 <211> 315 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(315) <400> 7 atg aaa ttt ttg aag aac aaa gca cct gct aat ctg gtg gat aac ggc 48 Met Lys Phe Leu Lys Asn Lys Ala Pro Ala Asn Leu Val Asp Asn Gly 1 5 10 15 agg ttt gtg gaa gca ata acg tgc aat aaa gtt aaa ccg aat cca tct 96 Arg Phe Val Glu Ala Ile Thr Cys Asn Lys Val Lys Pro Asn Pro Ser 20 25 30 tgc gtc tcc aac tgc ctc aaa ttt ctt tcc gaa gtt tta gcg gta gaa 144 Cys Val Ser Asn Cys Leu Lys Phe Leu Ser Glu Val Leu Ala Val Glu 35 40 45 gca ata act gat tcg gcc aga aat tta gct acg gtt tcc aaa tcg gac 192 Ala Ile Thr Asp Ser Ala Arg Asn Leu Ala Thr Val Ser Lys Ser Asp 50 55 60 atc cta cta ttt tct ctt cta caa ttg agt agc aat aaa cag agc ggg 240 Ile Leu Leu Phe Ser Leu Leu Gln Leu Ser Ser Asn Lys Gln Ser Gly 65 70 75 80 tcc tct ttg cca ctt ttt gat ctt gtg ttt ata cta ctt tca act ttt 288 Ser Ser Leu Pro Leu Phe Asp Leu Val Phe Ile Leu Leu Ser Thr Phe 85 90 95 ttt tta ttc cat aat ccc tgc aat tga 315 Phe Leu Phe His Asn Pro Cys Asn 100 <210> 8 <211> 104 <212> PRT <213> Saccharomyces cerevisiae <400> 8 Met Lys Phe Leu Lys Asn Lys Ala Pro Ala Asn Leu Val Asp Asn Gly 1 5 10 15 Arg Phe Val Glu Ala Ile Thr Cys Asn Lys Val Lys Pro Asn Pro Ser 20 25 30 Page 16 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Cys Val Ser Asn Cys Leu Lys Phe Leu Ser Glu Val Leu Ala Val Glu 35 40 45 Ala Ile Thr Asp Ser Ala Arg Asn Leu Ala Thr Val Ser Lys Ser Asp 50 55 60 Ile Leu Leu Phe Ser Leu Leu Gln Leu Ser Ser Asn Lys Gln Ser Gly 65 70 75 80 Ser Ser Leu Pro Leu Phe Asp Leu Val Phe Ile Leu Leu Ser Thr Phe 85 90 95 Phe Leu Phe His Asn Pro Cys Asn 100 <210> 9 <211> 2064 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2064) <400> 9 atg tgc gcc agt tta aac gag gta aaa aag aat gac acc tat ggg gtc 48 Met Cys Ala Ser Leu Asn Glu Val Lys Lys Asn Asp Thr Tyr Gly Val 1 5 10 15 tca caa aag ggc tac aat gac aat ttc agt gaa agt gag ggc gtc ctt 96 Ser Gln Lys Gly Tyr Asn Asp Asn Phe Ser Glu Ser Glu Gly Val Leu 20 25 30 cat ggt agt aag tcg atg ccc act agc atg aaa aat atg cta cag tct 144 His Gly Ser Lys Ser Met Pro Thr Ser Met Lys Asn Met Leu Gln Ser 35 40 45 ccc acg atg gtc aac atg tgt gat att tta caa aac aag gaa gct gct 192 Pro Thr Met Val Asn Met Cys Asp Ile Leu Gln Asn Lys Glu Ala Ala 50 55 60 aat gac gaa aaa cct gtg ata cct act acg gat acc gcc act gcg ggg 240 Asn Asp Glu Lys Pro Val Ile Pro Thr Thr Asp Thr Ala Thr Ala Gly 65 70 75 80 act ggt act gaa gat att agc tcc act caa tcc gag gaa act gat cag 288 Thr Gly Thr Glu Asp Ile Ser Ser Thr Gln Ser Glu Glu Thr Asp Gln 85 90 95 aat agt cat ctt att gcc tca gag atc ttg gaa ggc act ttc aaa gat 336 Asn Ser His Leu Ile Ala Ser Glu Ile Leu Glu Gly Thr Phe Lys Asp 100 105 110 gta tct tac aag gaa tat gca aat ttc ttg gga aac gat aac aat aat 384 Val Ser Tyr Lys Glu Tyr Ala Asn Phe Leu Gly Asn Asp Asn Asn Asn 115 120 125 caa gtc ttg act gag ttt gta aag tta ttg agt cct ttg ccg tcg tca 432 Gln Val Leu Thr Glu Phe Val Lys Leu Leu Ser Pro Leu Pro Ser Ser 130 135 140 cta tta gaa acg ctt ttc aat tta tcg aaa agt ata tat ttc att gca 480 Leu Leu Glu Thr Leu Phe Asn Leu Ser Lys Ser Ile Tyr Phe Ile Ala 145 150 155 160 Page 17 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa gcg caa aat atc gac cgg ata cta gag tgc ttg agc ata gaa tgg 528 Glu Ala Gln Asn Ile Asp Arg Ile Leu Glu Cys Leu Ser Ile Glu Trp 165 170 175 ata gct tgc cac ccg aac aca cat tgg aag tca ggc tat aag tca tgt 576 Ile Ala Cys His Pro Asn Thr His Trp Lys Ser Gly Tyr Lys Ser Cys 180 185 190 cat ata gtc tta ttt tcc ctg ttg atc ctt aat tcg gat ttg cac aac 624 His Ile Val Leu Phe Ser Leu Leu Ile Leu Asn Ser Asp Leu His Asn 195 200 205 aac ttt caa gtt gac cat aaa aag att aag ttt tcc atg gtt gca ttt 672 Asn Phe Gln Val Asp His Lys Lys Ile Lys Phe Ser Met Val Ala Phe 210 215 220 atc aac aat aca ctg agg gca cta aga gag gaa aat gaa tac gaa gaa 720 Ile Asn Asn Thr Leu Arg Ala Leu Arg Glu Glu Asn Glu Tyr Glu Glu 225 230 235 240 ttg aaa ata tac tcc cgc gaa cat ttg atc atc gaa gaa ctt tcc gaa 768 Leu Lys Ile Tyr Ser Arg Glu His Leu Ile Ile Glu Glu Leu Ser Glu 245 250 255 tac tat aaa acg tta aat gaa acg cct tta ccg tta tgc aca gaa tct 816 Tyr Tyr Lys Thr Leu Asn Glu Thr Pro Leu Pro Leu Cys Thr Glu Ser 260 265 270 aga aca tca ata aat ata tca gat aac caa tct tcc ttg aaa agg ttc 864 Arg Thr Ser Ile Asn Ile Ser Asp Asn Gln Ser Ser Leu Lys Arg Phe 275 280 285 tct act cta gga tca cgg gaa ttt agt aca tca aat tta cgt agt gtt 912 Ser Thr Leu Gly Ser Arg Glu Phe Ser Thr Ser Asn Leu Arg Ser Val 290 295 300 aac tct aat tct act aca cta tat tca aga gat ggt caa gta tct gta 960 Asn Ser Asn Ser Thr Thr Leu Tyr Ser Arg Asp Gly Gln Val Ser Val 305 310 315 320 cga gaa atg agc gca aaa tca aat aaa aac ttt cac aat aat cac ccc 1008 Arg Glu Met Ser Ala Lys Ser Asn Lys Asn Phe His Asn Asn His Pro 325 330 335 atg gat gca ctc tac ctt aaa gag tct ttt gat gac ggt tta att acc 1056 Met Asp Ala Leu Tyr Leu Lys Glu Ser Phe Asp Asp Gly Leu Ile Thr 340 345 350 gaa aac ggc tcc agt tgg ttc atg gac gat tta att ctt ata agc aag 1104 Glu Asn Gly Ser Ser Trp Phe Met Asp Asp Leu Ile Leu Ile Ser Lys 355 360 365 aaa tct tta cca cgt aaa tat tct aaa aga gac aaa gat caa gtg gcg 1152 Lys Ser Leu Pro Arg Lys Tyr Ser Lys Arg Asp Lys Asp Gln Val Ala 370 375 380 gca cca aaa atg acc tct aag aga aac aaa tcg ttc ttc gga tgg cta 1200 Ala Pro Lys Met Thr Ser Lys Arg Asn Lys Ser Phe Phe Gly Trp Leu 385 390 395 400 aaa cca tct aaa acg act aca ctt att gag cac aca tct aga agg act 1248 Lys Pro Ser Lys Thr Thr Thr Leu Ile Glu His Thr Ser Arg Arg Thr 405 410 415 tct tta tcg tat ttg aat aag gat tct gaa tgg gag agg gtg aaa ata 1296 Page 18 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Leu Ser Tyr Leu Asn Lys Asp Ser Glu Trp Glu Arg Val Lys Ile 420 425 430 cag gtc aag gag ggc aga att ttt att ttc aaa att aaa cca gat gtt 1344 Gln Val Lys Glu Gly Arg Ile Phe Ile Phe Lys Ile Lys Pro Asp Val 435 440 445 aag gat atc atc caa tca agt gaa aca gac agt gct acc atc gac tat 1392 Lys Asp Ile Ile Gln Ser Ser Glu Thr Asp Ser Ala Thr Ile Asp Tyr 450 455 460 ttc aaa gat atc agt agc tct tat ttt gct tac tca ctg ctt gaa gct 1440 Phe Lys Asp Ile Ser Ser Ser Tyr Phe Ala Tyr Ser Leu Leu Glu Ala 465 470 475 480 gaa gca cat gtc gtg caa gat aat ata att ata ggt agt gga gca atg 1488 Glu Ala His Val Val Gln Asp Asn Ile Ile Ile Gly Ser Gly Ala Met 485 490 495 aaa tca aat gtg tgt aac aaa aac acc aag agg aaa agt ggc aac ttt 1536 Lys Ser Asn Val Cys Asn Lys Asn Thr Lys Arg Lys Ser Gly Asn Phe 500 505 510 acc gtt agt ttt cca gag aat atc aac gga cca aag ctt gtt ctg gag 1584 Thr Val Ser Phe Pro Glu Asn Ile Asn Gly Pro Lys Leu Val Leu Glu 515 520 525 ttc cag acg aga agt gtt gaa gaa gcc cac aag ttt atg gac tgt atc 1632 Phe Gln Thr Arg Ser Val Glu Glu Ala His Lys Phe Met Asp Cys Ile 530 535 540 aac ttc tgg gca ggt agg att tct cca gtt cct tta aca caa ttc gaa 1680 Asn Phe Trp Ala Gly Arg Ile Ser Pro Val Pro Leu Thr Gln Phe Glu 545 550 555 560 gcc gta tct aac gca gaa tat gga tgg agt gac aag atc ttg aca gag 1728 Ala Val Ser Asn Ala Glu Tyr Gly Trp Ser Asp Lys Ile Leu Thr Glu 565 570 575 cac gct tcc ctc aat ctt aaa aat att gtt gta agt gaa tgg aag cca 1776 His Ala Ser Leu Asn Leu Lys Asn Ile Val Val Ser Glu Trp Lys Pro 580 585 590 cta ttg ggg cta gag cta cta tac gaa gat gcg aaa gat gta gag atg 1824 Leu Leu Gly Leu Glu Leu Leu Tyr Glu Asp Ala Lys Asp Val Glu Met 595 600 605 gtc gaa cta aaa gaa agg cta aag gaa ttg atg aac ttc acc aga cag 1872 Val Glu Leu Lys Glu Arg Leu Lys Glu Leu Met Asn Phe Thr Arg Gln 610 615 620 ctt ggt ata tgg ata gat aaa cat aac gaa ata aag gat aag ctg gtc 1920 Leu Gly Ile Trp Ile Asp Lys His Asn Glu Ile Lys Asp Lys Leu Val 625 630 635 640 gaa att tgg agc ttt gac gat aac tat ttt gaa gca gtc atg aat aat 1968 Glu Ile Trp Ser Phe Asp Asp Asn Tyr Phe Glu Ala Val Met Asn Asn 645 650 655 tgg aat tcg aga tat ttg tat atg aat aat caa tat aag aaa cga ctg 2016 Trp Asn Ser Arg Tyr Leu Tyr Met Asn Asn Gln Tyr Lys Lys Arg Leu 660 665 670 agc tac ttg aaa gct ttg caa aaa gcc atg ggt tct gtt cag ttc taa 2064 Ser Tyr Leu Lys Ala Leu Gln Lys Ala Met Gly Ser Val Gln Phe 675 680 685 Page 19 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 10 <211> 687 <212> PRT <213> Saccharomyces cerevisiae <400> 10 Met Cys Ala Ser Leu Asn Glu Val Lys Lys Asn Asp Thr Tyr Gly Val 1 5 10 15 Ser Gln Lys Gly Tyr Asn Asp Asn Phe Ser Glu Ser Glu Gly Val Leu 20 25 30 His Gly Ser Lys Ser Met Pro Thr Ser Met Lys Asn Met Leu Gln Ser 35 40 45 Pro Thr Met Val Asn Met Cys Asp Ile Leu Gln Asn Lys Glu Ala Ala 50 55 60 Asn Asp Glu Lys Pro Val Ile Pro Thr Thr Asp Thr Ala Thr Ala Gly 65 70 75 80 Thr Gly Thr Glu Asp Ile Ser Ser Thr Gln Ser Glu Glu Thr Asp Gln 85 90 95 Asn Ser His Leu Ile Ala Ser Glu Ile Leu Glu Gly Thr Phe Lys Asp 100 105 110 Val Ser Tyr Lys Glu Tyr Ala Asn Phe Leu Gly Asn Asp Asn Asn Asn 115 120 125 Gln Val Leu Thr Glu Phe Val Lys Leu Leu Ser Pro Leu Pro Ser Ser 130 135 140 Leu Leu Glu Thr Leu Phe Asn Leu Ser Lys Ser Ile Tyr Phe Ile Ala 145 150 155 160 Glu Ala Gln Asn Ile Asp Arg Ile Leu Glu Cys Leu Ser Ile Glu Trp 165 170 175 Ile Ala Cys His Pro Asn Thr His Trp Lys Ser Gly Tyr Lys Ser Cys 180 185 190 His Ile Val Leu Phe Ser Leu Leu Ile Leu Asn Ser Asp Leu His Asn 195 200 205 Asn Phe Gln Val Asp His Lys Lys Ile Lys Phe Ser Met Val Ala Phe 210 215 220 Ile Asn Asn Thr Leu Arg Ala Leu Arg Glu Glu Asn Glu Tyr Glu Glu 225 230 235 240 Leu Lys Ile Tyr Ser Arg Glu His Leu Ile Ile Glu Glu Leu Ser Glu 245 250 255 Tyr Tyr Lys Thr Leu Asn Glu Thr Pro Leu Pro Leu Cys Thr Glu Ser 260 265 270 Arg Thr Ser Ile Asn Ile Ser Asp Asn Gln Ser Ser Leu Lys Arg Phe 275 280 285 Ser Thr Leu Gly Ser Arg Glu Phe Ser Thr Ser Asn Leu Arg Ser Val 290 295 300 Asn Ser Asn Ser Thr Thr Leu Tyr Ser Arg Asp Gly Gln Val Ser Val 305 310 315 320 Page 20 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Glu Met Ser Ala Lys Ser Asn Lys Asn Phe His Asn Asn His Pro 325 330 335 Met Asp Ala Leu Tyr Leu Lys Glu Ser Phe Asp Asp Gly Leu Ile Thr 340 345 350 Glu Asn Gly Ser Ser Trp Phe Met Asp Asp Leu Ile Leu Ile Ser Lys 355 360 365 Lys Ser Leu Pro Arg Lys Tyr Ser Lys Arg Asp Lys Asp Gln Val Ala 370 375 380 Ala Pro Lys Met Thr Ser Lys Arg Asn Lys Ser Phe Phe Gly Trp Leu 385 390 395 400 Lys Pro Ser Lys Thr Thr Thr Leu Ile Glu His Thr Ser Arg Arg Thr 405 410 415 Ser Leu Ser Tyr Leu Asn Lys Asp Ser Glu Trp Glu Arg Val Lys Ile 420 425 430 Gln Val Lys Glu Gly Arg Ile Phe Ile Phe Lys Ile Lys Pro Asp Val 435 440 445 Lys Asp Ile Ile Gln Ser Ser Glu Thr Asp Ser Ala Thr Ile Asp Tyr 450 455 460 Phe Lys Asp Ile Ser Ser Ser Tyr Phe Ala Tyr Ser Leu Leu Glu Ala 465 470 475 480 Glu Ala His Val Val Gln Asp Asn Ile Ile Ile Gly Ser Gly Ala Met 485 490 495 Lys Ser Asn Val Cys Asn Lys Asn Thr Lys Arg Lys Ser Gly Asn Phe 500 505 510 Thr Val Ser Phe Pro Glu Asn Ile Asn Gly Pro Lys Leu Val Leu Glu 515 520 525 Phe Gln Thr Arg Ser Val Glu Glu Ala His Lys Phe Met Asp Cys Ile 530 535 540 Asn Phe Trp Ala Gly Arg Ile Ser Pro Val Pro Leu Thr Gln Phe Glu 545 550 555 560 Ala Val Ser Asn Ala Glu Tyr Gly Trp Ser Asp Lys Ile Leu Thr Glu 565 570 575 His Ala Ser Leu Asn Leu Lys Asn Ile Val Val Ser Glu Trp Lys Pro 580 585 590 Leu Leu Gly Leu Glu Leu Leu Tyr Glu Asp Ala Lys Asp Val Glu Met 595 600 605 Val Glu Leu Lys Glu Arg Leu Lys Glu Leu Met Asn Phe Thr Arg Gln 610 615 620 Leu Gly Ile Trp Ile Asp Lys His Asn Glu Ile Lys Asp Lys Leu Val 625 630 635 640 Glu Ile Trp Ser Phe Asp Asp Asn Tyr Phe Glu Ala Val Met Asn Asn 645 650 655 Trp Asn Ser Arg Tyr Leu Tyr Met Asn Asn Gln Tyr Lys Lys Arg Leu 660 665 670 Ser Tyr Leu Lys Ala Leu Gln Lys Ala Met Gly Ser Val Gln Phe Page 21 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 675 680 685 <210> 11 <211> 678 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(678) <400> 11 atg gtc gta att aac ggg gtc aaa tat gcc tgt gaa acg tgt atc agg 48 Met Val Val Ile Asn Gly Val Lys Tyr Ala Cys Glu Thr Cys Ile Arg 1 5 10 15 ggt cac agg gcg gcg cag tgt act cac act gat ggt ccg cta cag atg 96 Gly His Arg Ala Ala Gln Cys Thr His Thr Asp Gly Pro Leu Gln Met 20 25 30 atc aga cgc aag gga aga cca tcg acc aca tgt ggc cat tgt aaa gag 144 Ile Arg Arg Lys Gly Arg Pro Ser Thr Thr Cys Gly His Cys Lys Glu 35 40 45 ctg aga aga acc aag aac ttc aac cca tcc ggt ggg tgc atg tgt gcc 192 Leu Arg Arg Thr Lys Asn Phe Asn Pro Ser Gly Gly Cys Met Cys Ala 50 55 60 tct gca cga cgg cca gct gtt ggc agc aag gaa gat gaa aca cga tgt 240 Ser Ala Arg Arg Pro Ala Val Gly Ser Lys Glu Asp Glu Thr Arg Cys 65 70 75 80 cgt tgt gat gag ggt gaa cct tgt aaa tgt cat acc aag agg aaa agc 288 Arg Cys Asp Glu Gly Glu Pro Cys Lys Cys His Thr Lys Arg Lys Ser 85 90 95 agc cgg aaa tca aag gga ggg tca tgc cac aga agg gca aat gat gaa 336 Ser Arg Lys Ser Lys Gly Gly Ser Cys His Arg Arg Ala Asn Asp Glu 100 105 110 gca gcg cat gtc aat ggt ctc ggt att gca gat ctg gac gtt ctt ttg 384 Ala Ala His Val Asn Gly Leu Gly Ile Ala Asp Leu Asp Val Leu Leu 115 120 125 ggc cta aat ggt cgc tcg tcg gat gta gac atg aca acc aca ttg ccg 432 Gly Leu Asn Gly Arg Ser Ser Asp Val Asp Met Thr Thr Thr Leu Pro 130 135 140 agt ttg aag cca cct ctg caa aac gga gaa att aag gcc gac agc att 480 Ser Leu Lys Pro Pro Leu Gln Asn Gly Glu Ile Lys Ala Asp Ser Ile 145 150 155 160 gac aat ctt gat ttg gct tcc ctc gat ccg ctt gag caa agc cct agt 528 Asp Asn Leu Asp Leu Ala Ser Leu Asp Pro Leu Glu Gln Ser Pro Ser 165 170 175 ata tct atg gaa cct gtt agt atc aat gaa aca gga agc gca tat aca 576 Ile Ser Met Glu Pro Val Ser Ile Asn Glu Thr Gly Ser Ala Tyr Thr 180 185 190 act acg aac aca gca cta aac gat att gac att cca ttc tcc atc aat 624 Thr Thr Asn Thr Ala Leu Asn Asp Ile Asp Ile Pro Phe Ser Ile Asn 195 200 205 Page 22 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gag ttg aac gag cta tac aaa caa gta tct tcg cat aac tca cat tca 672 Glu Leu Asn Glu Leu Tyr Lys Gln Val Ser Ser His Asn Ser His Ser 210 215 220 caa taa 678 Gln 225 <210> 12 <211> 225 <212> PRT <213> Saccharomyces cerevisiae <400> 12 Met Val Val Ile Asn Gly Val Lys Tyr Ala Cys Glu Thr Cys Ile Arg 1 5 10 15 Gly His Arg Ala Ala Gln Cys Thr His Thr Asp Gly Pro Leu Gln Met 20 25 30 Ile Arg Arg Lys Gly Arg Pro Ser Thr Thr Cys Gly His Cys Lys Glu 35 40 45 Leu Arg Arg Thr Lys Asn Phe Asn Pro Ser Gly Gly Cys Met Cys Ala 50 55 60 Ser Ala Arg Arg Pro Ala Val Gly Ser Lys Glu Asp Glu Thr Arg Cys 65 70 75 80 Arg Cys Asp Glu Gly Glu Pro Cys Lys Cys His Thr Lys Arg Lys Ser 85 90 95 Ser Arg Lys Ser Lys Gly Gly Ser Cys His Arg Arg Ala Asn Asp Glu 100 105 110 Ala Ala His Val Asn Gly Leu Gly Ile Ala Asp Leu Asp Val Leu Leu 115 120 125 Gly Leu Asn Gly Arg Ser Ser Asp Val Asp Met Thr Thr Thr Leu Pro 130 135 140 Ser Leu Lys Pro Pro Leu Gln Asn Gly Glu Ile Lys Ala Asp Ser Ile 145 150 155 160 Asp Asn Leu Asp Leu Ala Ser Leu Asp Pro Leu Glu Gln Ser Pro Ser 165 170 175 Ile Ser Met Glu Pro Val Ser Ile Asn Glu Thr Gly Ser Ala Tyr Thr 180 185 190 Thr Thr Asn Thr Ala Leu Asn Asp Ile Asp Ile Pro Phe Ser Ile Asn 195 200 205 Glu Leu Asn Glu Leu Tyr Lys Gln Val Ser Ser His Asn Ser His Ser 210 215 220 Gln 225 <210> 13 <211> 750 <212> DNA <213> Saccharomyces cerevisiae Page 23 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(750) <400> 13 atg ttg cag cta agg ttt atg cct gga tgg gtc ccc aga aat ggt ttt 48 Met Leu Gln Leu Arg Phe Met Pro Gly Trp Val Pro Arg Asn Gly Phe 1 5 10 15 ttt ggt ttg aag gag aca att ggt aca gta cat aag aga ttt tat gct 96 Phe Gly Leu Lys Glu Thr Ile Gly Thr Val His Lys Arg Phe Tyr Ala 20 25 30 ctg gct tct gaa caa ccc tca aga aag aca gta aag ccg ctg gac tcg 144 Leu Ala Ser Glu Gln Pro Ser Arg Lys Thr Val Lys Pro Leu Asp Ser 35 40 45 agg aag acg ttt ctc atc gat aca tac aag cat tta atg gag aac agt 192 Arg Lys Thr Phe Leu Ile Asp Thr Tyr Lys His Leu Met Glu Asn Ser 50 55 60 tct atg att ttt ttt gtc cat tac aat aat ctt tcc aaa aca gaa gat 240 Ser Met Ile Phe Phe Val His Tyr Asn Asn Leu Ser Lys Thr Glu Asp 65 70 75 80 cac cat ttc aga ttc aag att aaa cag aca gga ggg aaa ctc aca aaa 288 His His Phe Arg Phe Lys Ile Lys Gln Thr Gly Gly Lys Leu Thr Lys 85 90 95 gta aga aac aac ctg ttc gaa gtc tac ttg aga aat tcg cat ctg ccc 336 Val Arg Asn Asn Leu Phe Glu Val Tyr Leu Arg Asn Ser His Leu Pro 100 105 110 gac cca tgt gga ttc gtg aag cgt aaa gag caa aac tgg aaa cat cca 384 Asp Pro Cys Gly Phe Val Lys Arg Lys Glu Gln Asn Trp Lys His Pro 115 120 125 ctc ttg cca cta ctg aag ggt cct acg gcc aca att aca tac gaa gac 432 Leu Leu Pro Leu Leu Lys Gly Pro Thr Ala Thr Ile Thr Tyr Glu Asp 130 135 140 acc aac cct caa caa gta gcc aag cta ttg aag gtt ctg cag tca gca 480 Thr Asn Pro Gln Gln Val Ala Lys Leu Leu Lys Val Leu Gln Ser Ala 145 150 155 160 caa gac aag ctg atg gtg att ggt gca aaa gta gaa aac gaa gtt ttg 528 Gln Asp Lys Leu Met Val Ile Gly Ala Lys Val Glu Asn Glu Val Leu 165 170 175 aat gtg gaa aaa ata aac act ttt aag act ctc ccc aca aag ccg gaa 576 Asn Val Glu Lys Ile Asn Thr Phe Lys Thr Leu Pro Thr Lys Pro Glu 180 185 190 atg cag tcg cag tta gtc agc gtt ttg caa atg cta agt ggg ttg ggt 624 Met Gln Ser Gln Leu Val Ser Val Leu Gln Met Leu Ser Gly Leu Gly 195 200 205 ttg gtt cgt acg ttg gaa aac agt tca aat gca ttg tat tta aca cta 672 Leu Val Arg Thr Leu Glu Asn Ser Ser Asn Ala Leu Tyr Leu Thr Leu 210 215 220 aaa tct cac aat gac aac caa aaa cct aaa gag gat gtg gag tca act 720 Lys Ser His Asn Asp Asn Gln Lys Pro Lys Glu Asp Val Glu Ser Thr 225 230 235 240 aca gat gca gaa tcg aag gga tca aag taa 750 Thr Asp Ala Glu Ser Lys Gly Ser Lys Page 24 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 245 <210> 14 <211> 249 <212> PRT <213> Saccharomyces cerevisiae <400> 14 Met Leu Gln Leu Arg Phe Met Pro Gly Trp Val Pro Arg Asn Gly Phe 1 5 10 15 Phe Gly Leu Lys Glu Thr Ile Gly Thr Val His Lys Arg Phe Tyr Ala 20 25 30 Leu Ala Ser Glu Gln Pro Ser Arg Lys Thr Val Lys Pro Leu Asp Ser 35 40 45 Arg Lys Thr Phe Leu Ile Asp Thr Tyr Lys His Leu Met Glu Asn Ser 50 55 60 Ser Met Ile Phe Phe Val His Tyr Asn Asn Leu Ser Lys Thr Glu Asp 65 70 75 80 His His Phe Arg Phe Lys Ile Lys Gln Thr Gly Gly Lys Leu Thr Lys 85 90 95 Val Arg Asn Asn Leu Phe Glu Val Tyr Leu Arg Asn Ser His Leu Pro 100 105 110 Asp Pro Cys Gly Phe Val Lys Arg Lys Glu Gln Asn Trp Lys His Pro 115 120 125 Leu Leu Pro Leu Leu Lys Gly Pro Thr Ala Thr Ile Thr Tyr Glu Asp 130 135 140 Thr Asn Pro Gln Gln Val Ala Lys Leu Leu Lys Val Leu Gln Ser Ala 145 150 155 160 Gln Asp Lys Leu Met Val Ile Gly Ala Lys Val Glu Asn Glu Val Leu 165 170 175 Asn Val Glu Lys Ile Asn Thr Phe Lys Thr Leu Pro Thr Lys Pro Glu 180 185 190 Met Gln Ser Gln Leu Val Ser Val Leu Gln Met Leu Ser Gly Leu Gly 195 200 205 Leu Val Arg Thr Leu Glu Asn Ser Ser Asn Ala Leu Tyr Leu Thr Leu 210 215 220 Lys Ser His Asn Asp Asn Gln Lys Pro Lys Glu Asp Val Glu Ser Thr 225 230 235 240 Thr Asp Ala Glu Ser Lys Gly Ser Lys 245 <210> 15 <211> 357 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS Page 25 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(357) <400> 15 atg aag ctc cca cag acc atg cta cgt tct ata tct gtg aag cat gtc 48 Met Lys Leu Pro Gln Thr Met Leu Arg Ser Ile Ser Val Lys His Val 1 5 10 15 cgg tgg cca agg att ctg acg ggc tca aag ctt tgg tac tca acg cag 96 Arg Trp Pro Arg Ile Leu Thr Gly Ser Lys Leu Trp Tyr Ser Thr Gln 20 25 30 atg gca atg act ccg gag gag aag atg atc acc gat aaa cta caa cag 144 Met Ala Met Thr Pro Glu Glu Lys Met Ile Thr Asp Lys Leu Gln Gln 35 40 45 gaa ctg gaa cct gaa gtg tgt aaa gtg caa gac gtt tcc ggt ggc tgc 192 Glu Leu Glu Pro Glu Val Cys Lys Val Gln Asp Val Ser Gly Gly Cys 50 55 60 gga tcc atg ttt gct atc aac ata aca agc aag aag ttc aac gga ctg 240 Gly Ser Met Phe Ala Ile Asn Ile Thr Ser Lys Lys Phe Asn Gly Leu 65 70 75 80 agt ctc atc aag cag cac cag ctg gtg aac aga att ttg agg gac gat 288 Ser Leu Ile Lys Gln His Gln Leu Val Asn Arg Ile Leu Arg Asp Asp 85 90 95 att tcc aga tgg cat ggc cta caa ttg acc act aag aag tca act ggg 336 Ile Ser Arg Trp His Gly Leu Gln Leu Thr Thr Lys Lys Ser Thr Gly 100 105 110 aag ggt ccg gca tca tca tga 357 Lys Gly Pro Ala Ser Ser 115 <210> 16 <211> 118 <212> PRT <213> Saccharomyces cerevisiae <400> 16 Met Lys Leu Pro Gln Thr Met Leu Arg Ser Ile Ser Val Lys His Val 1 5 10 15 Arg Trp Pro Arg Ile Leu Thr Gly Ser Lys Leu Trp Tyr Ser Thr Gln 20 25 30 Met Ala Met Thr Pro Glu Glu Lys Met Ile Thr Asp Lys Leu Gln Gln 35 40 45 Glu Leu Glu Pro Glu Val Cys Lys Val Gln Asp Val Ser Gly Gly Cys 50 55 60 Gly Ser Met Phe Ala Ile Asn Ile Thr Ser Lys Lys Phe Asn Gly Leu 65 70 75 80 Ser Leu Ile Lys Gln His Gln Leu Val Asn Arg Ile Leu Arg Asp Asp 85 90 95 Ile Ser Arg Trp His Gly Leu Gln Leu Thr Thr Lys Lys Ser Thr Gly Page 26 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 100 105 110 Lys Gly Pro Ala Ser Ser 115 <210> 17 <211> 1782 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1782) <400> 17 atg gct cta gct atc tcc cac gag gat act cag att ttg cta aag gac 48 Met Ala Leu Ala Ile Ser His Glu Asp Thr Gln Ile Leu Leu Lys Asp 1 5 10 15 aaa aat att cta cag gaa tcg gtc ttg aac aaa tac aga act gct gga 96 Lys Asn Ile Leu Gln Glu Ser Val Leu Asn Lys Tyr Arg Thr Ala Gly 20 25 30 caa atc gca caa act gct ttg aaa tat gtt act tct ttg atc aat gat 144 Gln Ile Ala Gln Thr Ala Leu Lys Tyr Val Thr Ser Leu Ile Asn Asp 35 40 45 tca tat cac tct aag acc aca cag cgc caa tta acc gtg cca gag cta 192 Ser Tyr His Ser Lys Thr Thr Gln Arg Gln Leu Thr Val Pro Glu Leu 50 55 60 tgt ttg ctt acc gat tct ttt att ttg acc cgg ttg gaa caa tat tat 240 Cys Leu Leu Thr Asp Ser Phe Ile Leu Thr Arg Leu Glu Gln Tyr Tyr 65 70 75 80 aaa aac aaa gtt aat gaa aga ggt att gcc att cca acc act att gat 288 Lys Asn Lys Val Asn Glu Arg Gly Ile Ala Ile Pro Thr Thr Ile Asp 85 90 95 atc gac caa att tct ggt gga tgg tgc ccc gaa ata gat gat act caa 336 Ile Asp Gln Ile Ser Gly Gly Trp Cys Pro Glu Ile Asp Asp Thr Gln 100 105 110 aat ttg tta aac tgg aat aag ggg aaa gac tcc act ttt gca tca tct 384 Asn Leu Leu Asn Trp Asn Lys Gly Lys Asp Ser Thr Phe Ala Ser Ser 115 120 125 gtc act ggg act ttg aga ccg ggg gat tta gtc aag att aca cta ggt 432 Val Thr Gly Thr Leu Arg Pro Gly Asp Leu Val Lys Ile Thr Leu Gly 130 135 140 gtt cat att gat ggt tac acc tct gaa gtt tct cat act atg gtt att 480 Val His Ile Asp Gly Tyr Thr Ser Glu Val Ser His Thr Met Val Ile 145 150 155 160 tac ccc gtt gat gaa acc aaa cct att ctt caa ccc act ggg cca cta 528 Tyr Pro Val Asp Glu Thr Lys Pro Ile Leu Gln Pro Thr Gly Pro Leu 165 170 175 cta ggt ggt aaa gcg gat gct gta gct gct gct cac att gct atg gaa 576 Leu Gly Gly Lys Ala Asp Ala Val Ala Ala Ala His Ile Ala Met Glu 180 185 190 Page 27 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aca gtt gtt gct tta tta gcc tgt gct ctg act cca gaa aag ctt cct 624 Thr Val Val Ala Leu Leu Ala Cys Ala Leu Thr Pro Glu Lys Leu Pro 195 200 205 gcc tca ctg gga gga act tca agt ggt atc aca ggc caa ttg att aga 672 Ala Ser Leu Gly Gly Thr Ser Ser Gly Ile Thr Gly Gln Leu Ile Arg 210 215 220 act ata gtg gat act att gcc aga tct tat aac tgt ggc gtt gtt cct 720 Thr Ile Val Asp Thr Ile Ala Arg Ser Tyr Asn Cys Gly Val Val Pro 225 230 235 240 ggt tct cgt gta aga agg att aga aga ttc ctg gca ggc caa aac gaa 768 Gly Ser Arg Val Arg Arg Ile Arg Arg Phe Leu Ala Gly Gln Asn Glu 245 250 255 ggt att gtt gcc gaa agg gaa tat aag ggt gtt gtt tgg aca gag tcc 816 Gly Ile Val Ala Glu Arg Glu Tyr Lys Gly Val Val Trp Thr Glu Ser 260 265 270 cat caa gaa gca gat ttg cta tct aat act gat gcc aag gat tta aca 864 His Gln Glu Ala Asp Leu Leu Ser Asn Thr Asp Ala Lys Asp Leu Thr 275 280 285 gtg gta gat cgt gga caa tcg act cca ttc act aat gtt tct gct att 912 Val Val Asp Arg Gly Gln Ser Thr Pro Phe Thr Asn Val Ser Ala Ile 290 295 300 cca agt gat gat ttc gtt gtt caa tca ggt gaa gtg tat tta att gat 960 Pro Ser Asp Asp Phe Val Val Gln Ser Gly Glu Val Tyr Leu Ile Asp 305 310 315 320 ttg aaa atg gca tct ttg gag cat tgt acc aaa aag ggt tta gta act 1008 Leu Lys Met Ala Ser Leu Glu His Cys Thr Lys Lys Gly Leu Val Thr 325 330 335 tta gaa acc gtt gac tct tac aca ggt aaa tct cat aag gct gga gaa 1056 Leu Glu Thr Val Asp Ser Tyr Thr Gly Lys Ser His Lys Ala Gly Glu 340 345 350 ttg att gca aga ccc ggt gca tat gtt aga gat ttt gct caa acc cat 1104 Leu Ile Ala Arg Pro Gly Ala Tyr Val Arg Asp Phe Ala Gln Thr His 355 360 365 att ctt aaa tta aaa act tct aga caa tta tta act aaa atc gat aaa 1152 Ile Leu Lys Leu Lys Thr Ser Arg Gln Leu Leu Thr Lys Ile Asp Lys 370 375 380 caa ggc gtt tat cca ttc aag tta tct cat tta tct tct aac ttt cct 1200 Gln Gly Val Tyr Pro Phe Lys Leu Ser His Leu Ser Ser Asn Phe Pro 385 390 395 400 ttc gtt cac gaa aat gaa gaa gaa ctc caa agc tta aag aaa gat ttg 1248 Phe Val His Glu Asn Glu Glu Glu Leu Gln Ser Leu Lys Lys Asp Leu 405 410 415 aaa tca ttt aga ctt ggg atg agt gag att tcc aac aac tac tta tgt 1296 Lys Ser Phe Arg Leu Gly Met Ser Glu Ile Ser Asn Asn Tyr Leu Cys 420 425 430 gtg gaa agt cca ata caa att gct aga tgg gtt cca tgg gac cat att 1344 Val Glu Ser Pro Ile Gln Ile Ala Arg Trp Val Pro Trp Asp His Ile 435 440 445 tta aag gct acc aat cca aac ggt aat tta agt tat gat gca acc tct 1392 Leu Lys Ala Thr Asn Pro Asn Gly Asn Leu Ser Tyr Asp Ala Thr Ser Page 28 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 450 455 460 aca tta aca tta cct ggg cat gag tta cct tta cca aaa ttg ggt gtt 1440 Thr Leu Thr Leu Pro Gly His Glu Leu Pro Leu Pro Lys Leu Gly Val 465 470 475 480 tca gcc atc aag ctt aaa tcc tta atg aat tca acc aag gaa tcg att 1488 Ser Ala Ile Lys Leu Lys Ser Leu Met Asn Ser Thr Lys Glu Ser Ile 485 490 495 tct tta cca gtt gct cgt gaa tgt aat acc atc gta tta tgt gac tct 1536 Ser Leu Pro Val Ala Arg Glu Cys Asn Thr Ile Val Leu Cys Asp Ser 500 505 510 agt gta agt aca acg gac aga ccc gaa tta ttg aga tta act ggt ggt 1584 Ser Val Ser Thr Thr Asp Arg Pro Glu Leu Leu Arg Leu Thr Gly Gly 515 520 525 tct aag acc tgt caa ccg agc tgg att cac tct cag cac gaa tta aat 1632 Ser Lys Thr Cys Gln Pro Ser Trp Ile His Ser Gln His Glu Leu Asn 530 535 540 cca caa gat tca att gtt caa ggg atc ttt caa tta gct act ttg gcc 1680 Pro Gln Asp Ser Ile Val Gln Gly Ile Phe Gln Leu Ala Thr Leu Ala 545 550 555 560 aag gat aag agg ttc ggt cta tta tta aag gaa acg cag cca atg aag 1728 Lys Asp Lys Arg Phe Gly Leu Leu Leu Lys Glu Thr Gln Pro Met Lys 565 570 575 cag aag agt gtt gag aca tca aat ggc gga gtt gaa gaa acc atg aaa 1776 Gln Lys Ser Val Glu Thr Ser Asn Gly Gly Val Glu Glu Thr Met Lys 580 585 590 atg tag 1782 Met <210> 18 <211> 593 <212> PRT <213> Saccharomyces cerevisiae <400> 18 Met Ala Leu Ala Ile Ser His Glu Asp Thr Gln Ile Leu Leu Lys Asp 1 5 10 15 Lys Asn Ile Leu Gln Glu Ser Val Leu Asn Lys Tyr Arg Thr Ala Gly 20 25 30 Gln Ile Ala Gln Thr Ala Leu Lys Tyr Val Thr Ser Leu Ile Asn Asp 35 40 45 Ser Tyr His Ser Lys Thr Thr Gln Arg Gln Leu Thr Val Pro Glu Leu 50 55 60 Cys Leu Leu Thr Asp Ser Phe Ile Leu Thr Arg Leu Glu Gln Tyr Tyr 65 70 75 80 Lys Asn Lys Val Asn Glu Arg Gly Ile Ala Ile Pro Thr Thr Ile Asp Page 29 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Ile Asp Gln Ile Ser Gly Gly Trp Cys Pro Glu Ile Asp Asp Thr Gln 100 105 110 Asn Leu Leu Asn Trp Asn Lys Gly Lys Asp Ser Thr Phe Ala Ser Ser 115 120 125 Val Thr Gly Thr Leu Arg Pro Gly Asp Leu Val Lys Ile Thr Leu Gly 130 135 140 Val His Ile Asp Gly Tyr Thr Ser Glu Val Ser His Thr Met Val Ile 145 150 155 160 Tyr Pro Val Asp Glu Thr Lys Pro Ile Leu Gln Pro Thr Gly Pro Leu 165 170 175 Leu Gly Gly Lys Ala Asp Ala Val Ala Ala Ala His Ile Ala Met Glu 180 185 190 Thr Val Val Ala Leu Leu Ala Cys Ala Leu Thr Pro Glu Lys Leu Pro 195 200 205 Ala Ser Leu Gly Gly Thr Ser Ser Gly Ile Thr Gly Gln Leu Ile Arg 210 215 220 Thr Ile Val Asp Thr Ile Ala Arg Ser Tyr Asn Cys Gly Val Val Pro 225 230 235 240 Gly Ser Arg Val Arg Arg Ile Arg Arg Phe Leu Ala Gly Gln Asn Glu 245 250 255 Gly Ile Val Ala Glu Arg Glu Tyr Lys Gly Val Val Trp Thr Glu Ser 260 265 270 His Gln Glu Ala Asp Leu Leu Ser Asn Thr Asp Ala Lys Asp Leu Thr 275 280 285 Val Val Asp Arg Gly Gln Ser Thr Pro Phe Thr Asn Val Ser Ala Ile 290 295 300 Pro Ser Asp Asp Phe Val Val Gln Ser Gly Glu Val Tyr Leu Ile Asp 305 310 315 320 Leu Lys Met Ala Ser Leu Glu His Cys Thr Lys Lys Gly Leu Val Thr 325 330 335 Leu Glu Thr Val Asp Ser Tyr Thr Gly Lys Ser His Lys Ala Gly Glu 340 345 350 Leu Ile Ala Arg Pro Gly Ala Tyr Val Arg Asp Phe Ala Gln Thr His Page 30 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 355 360 365 Ile Leu Lys Leu Lys Thr Ser Arg Gln Leu Leu Thr Lys Ile Asp Lys 370 375 380 Gln Gly Val Tyr Pro Phe Lys Leu Ser His Leu Ser Ser Asn Phe Pro 385 390 395 400 Phe Val His Glu Asn Glu Glu Glu Leu Gln Ser Leu Lys Lys Asp Leu 405 410 415 Lys Ser Phe Arg Leu Gly Met Ser Glu Ile Ser Asn Asn Tyr Leu Cys 420 425 430 Val Glu Ser Pro Ile Gln Ile Ala Arg Trp Val Pro Trp Asp His Ile 435 440 445 Leu Lys Ala Thr Asn Pro Asn Gly Asn Leu Ser Tyr Asp Ala Thr Ser 450 455 460 Thr Leu Thr Leu Pro Gly His Glu Leu Pro Leu Pro Lys Leu Gly Val 465 470 475 480 Ser Ala Ile Lys Leu Lys Ser Leu Met Asn Ser Thr Lys Glu Ser Ile 485 490 495 Ser Leu Pro Val Ala Arg Glu Cys Asn Thr Ile Val Leu Cys Asp Ser 500 505 510 Ser Val Ser Thr Thr Asp Arg Pro Glu Leu Leu Arg Leu Thr Gly Gly 515 520 525 Ser Lys Thr Cys Gln Pro Ser Trp Ile His Ser Gln His Glu Leu Asn 530 535 540 Pro Gln Asp Ser Ile Val Gln Gly Ile Phe Gln Leu Ala Thr Leu Ala 545 550 555 560 Lys Asp Lys Arg Phe Gly Leu Leu Leu Lys Glu Thr Gln Pro Met Lys 565 570 575 Gln Lys Ser Val Glu Thr Ser Asn Gly Gly Val Glu Glu Thr Met Lys 580 585 590 Met <210> 19 <211> 2097 <212> DNA <213> Saccharomyces cerevisiae Page 31 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(2097) <400> 19 atg gtt ttt tct tat gag cac tat atg aat ctc ctt ttc cat ttg gat 48 Met Val Phe Ser Tyr Glu His Tyr Met Asn Leu Leu Phe His Leu Asp 1 5 10 15 aac agt aaa gaa acg gtg cct cca gag att gca aaa aga ata att tca 96 Asn Ser Lys Glu Thr Val Pro Pro Glu Ile Ala Lys Arg Ile Ile Ser 20 25 30 aat gct ata gct cct gta ata aca gtt act tca act cct ctc ttc gac 144 Asn Ala Ile Ala Pro Val Ile Thr Val Thr Ser Thr Pro Leu Phe Asp 35 40 45 aaa cat att caa gaa acg tac aaa gta gat tct ctc tat atg ctg ctg 192 Lys His Ile Gln Glu Thr Tyr Lys Val Asp Ser Leu Tyr Met Leu Leu 50 55 60 cga ttc ttt ggc ggt tgt gtc tct gat aga gat caa gcc aat gaa gcg 240 Arg Phe Phe Gly Gly Cys Val Ser Asp Arg Asp Gln Ala Asn Glu Ala 65 70 75 80 aag gtt gga cag cat gag cat gag gtt tgt gat gca agt gac tcg acg 288 Lys Val Gly Gln His Glu His Glu Val Cys Asp Ala Ser Asp Ser Thr 85 90 95 gat tca att ccc aaa aat aaa aat ttg gaa gtg ccc aat tta tca aag 336 Asp Ser Ile Pro Lys Asn Lys Asn Leu Glu Val Pro Asn Leu Ser Lys 100 105 110 aaa ggt agt cgc agt agg tcg aat agt ctt ttc cag agg gat tca acg 384 Lys Gly Ser Arg Ser Arg Ser Asn Ser Leu Phe Gln Arg Asp Ser Thr 115 120 125 caa tct caa tat atc agg ttt aca agg cca tta ggt gac ttg atc gaa 432 Gln Ser Gln Tyr Ile Arg Phe Thr Arg Pro Leu Gly Asp Leu Ile Glu 130 135 140 aca aga gat gca aat gat atg tta ttc aat tac cat tct tta gag gta 480 Thr Arg Asp Ala Asn Asp Met Leu Phe Asn Tyr His Ser Leu Glu Val 145 150 155 160 ttc tta gat aat tat ttg aaa ttg gtt gca gca aat act gat gaa atg 528 Phe Leu Asp Asn Tyr Leu Lys Leu Val Ala Ala Asn Thr Asp Glu Met 165 170 175 gtt cct cat aat ctt ctt aag aaa tcc att tat cat agt ttc ttt tca 576 Val Pro His Asn Leu Leu Lys Lys Ser Ile Tyr His Ser Phe Phe Ser 180 185 190 cta gca att tca tcc aca aat aac tta tcg ccc tat gaa act ttt aat 624 Leu Ala Ile Ser Ser Thr Asn Asn Leu Ser Pro Tyr Glu Thr Phe Asn 195 200 205 cac cct att ctt tcc ttg att gct tta gat ata tca aat ggc gaa gtt 672 His Pro Ile Leu Ser Leu Ile Ala Leu Asp Ile Ser Asn Gly Glu Val 210 215 220 tat gag gat gca aga gat ctt tta gtc aat ttc aag aat ctt aat cat 720 Tyr Glu Asp Ala Arg Asp Leu Leu Val Asn Phe Lys Asn Leu Asn His 225 230 235 240 aat act gaa aac ttt cct atc ttc atg aat aca aat gaa atg ctt cca 768 Page 32 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Thr Glu Asn Phe Pro Ile Phe Met Asn Thr Asn Glu Met Leu Pro 245 250 255 gtt ttc tta ctc tgc tac aat gac gat tcc caa gaa gaa ttc gaa aaa 816 Val Phe Leu Leu Cys Tyr Asn Asp Asp Ser Gln Glu Glu Phe Glu Lys 260 265 270 tgc cag gcg tta gct aag aaa cta aag aag cag ttg ttt gtt gag agt 864 Cys Gln Ala Leu Ala Lys Lys Leu Lys Lys Gln Leu Phe Val Glu Ser 275 280 285 atc tta cta gca ctc tgg aag gat tct ttt att tac gac gaa aat tca 912 Ile Leu Leu Ala Leu Trp Lys Asp Ser Phe Ile Tyr Asp Glu Asn Ser 290 295 300 gtc ata cag tta cac caa cca gta atg tca tcg ctt gaa gaa att ctc 960 Val Ile Gln Leu His Gln Pro Val Met Ser Ser Leu Glu Glu Ile Leu 305 310 315 320 ttc ttc ctt caa gct cca act caa aca aca ctc tct ctg gct ttg ata 1008 Phe Phe Leu Gln Ala Pro Thr Gln Thr Thr Leu Ser Leu Ala Leu Ile 325 330 335 aac tcg atc tat gat atg ctt gat tat ttg gtt tat gat tta atg ata 1056 Asn Ser Ile Tyr Asp Met Leu Asp Tyr Leu Val Tyr Asp Leu Met Ile 340 345 350 cca ttc atg aaa aga aaa gtg tca ttc tgg gaa gag aca att tta cag 1104 Pro Phe Met Lys Arg Lys Val Ser Phe Trp Glu Glu Thr Ile Leu Gln 355 360 365 cca aga aag tcg cta ttt aat ggt gca aag ttt ttc aaa aaa ttt atg 1152 Pro Arg Lys Ser Leu Phe Asn Gly Ala Lys Phe Phe Lys Lys Phe Met 370 375 380 aat aaa aat cct gtc aat ggt aat cac caa cat aat tct cta acg aga 1200 Asn Lys Asn Pro Val Asn Gly Asn His Gln His Asn Ser Leu Thr Arg 385 390 395 400 gac agc cag gga aat gaa tac ttc gca tcg tca tct tct gag ttt ttg 1248 Asp Ser Gln Gly Asn Glu Tyr Phe Ala Ser Ser Ser Ser Glu Phe Leu 405 410 415 atg aga aag tta gca gat tgg tct atg atg cta tcc gac ttc aaa act 1296 Met Arg Lys Leu Ala Asp Trp Ser Met Met Leu Ser Asp Phe Lys Thr 420 425 430 gct tat tcc aca tac gaa tcg ctt atg gat gac cta gat gca ttt cca 1344 Ala Tyr Ser Thr Tyr Glu Ser Leu Met Asp Asp Leu Asp Ala Phe Pro 435 440 445 aag tac ctg gca tca tgc atc gaa tgg tgc gcg gta tca cta ttg atg 1392 Lys Tyr Leu Ala Ser Cys Ile Glu Trp Cys Ala Val Ser Leu Leu Met 450 455 460 ggt gcg cag agc ata gtc acc gtg aaa atg atc aaa aac gat ata aat 1440 Gly Ala Gln Ser Ile Val Thr Val Lys Met Ile Lys Asn Asp Ile Asn 465 470 475 480 cct ctt atc gaa agg gca tta gcc aca tac gaa aac tgc tca cga ata 1488 Pro Leu Ile Glu Arg Ala Leu Ala Thr Tyr Glu Asn Cys Ser Arg Ile 485 490 495 caa cgt ggt aaa ggc aaa gaa tca aac tct ttg gat gtt aca gag cca 1536 Gln Arg Gly Lys Gly Lys Glu Ser Asn Ser Leu Asp Val Thr Glu Pro 500 505 510 Page 33 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gtg cgt tcg tat gag aca cgt tgt atg att ttg gca tct gaa ttg ttt 1584 Val Arg Ser Tyr Glu Thr Arg Cys Met Ile Leu Ala Ser Glu Leu Phe 515 520 525 tta tct tta agc aat acg tgg aca tct acc cca tac gct atc caa tat 1632 Leu Ser Leu Ser Asn Thr Trp Thr Ser Thr Pro Tyr Ala Ile Gln Tyr 530 535 540 tta gaa aca att cta gac gag tgc aag ttg gga cct tgt tca cag ata 1680 Leu Glu Thr Ile Leu Asp Glu Cys Lys Leu Gly Pro Cys Ser Gln Ile 545 550 555 560 atg gtt tgg gaa agg ctt agt gac tgc tat aat ttg aga gtt gac cct 1728 Met Val Trp Glu Arg Leu Ser Asp Cys Tyr Asn Leu Arg Val Asp Pro 565 570 575 aga atc aaa cat aga gtt gga gca atg aag aag gac gct aaa gac acc 1776 Arg Ile Lys His Arg Val Gly Ala Met Lys Lys Asp Ala Lys Asp Thr 580 585 590 gaa gat ctc cga ggt gag cat aag tat agc aca gat cat ttc aca gac 1824 Glu Asp Leu Arg Gly Glu His Lys Tyr Ser Thr Asp His Phe Thr Asp 595 600 605 gag gac ata tta tcg gaa ggg tta aca aga aga cgc aag gca gct ttt 1872 Glu Asp Ile Leu Ser Glu Gly Leu Thr Arg Arg Arg Lys Ala Ala Phe 610 615 620 ttt agg tta ata gca gct aag aag tgg gca gag caa aaa caa tgg aga 1920 Phe Arg Leu Ile Ala Ala Lys Lys Trp Ala Glu Gln Lys Gln Trp Arg 625 630 635 640 cag gtt tct tgg tgc tta aaa gat att gaa agt acc tat tca gag atc 1968 Gln Val Ser Trp Cys Leu Lys Asp Ile Glu Ser Thr Tyr Ser Glu Ile 645 650 655 aaa ttt ttg cat ggt aac ggt tta att tta agc aaa cta aaa aat caa 2016 Lys Phe Leu His Gly Asn Gly Leu Ile Leu Ser Lys Leu Lys Asn Gln 660 665 670 ctc aat tta aag gac gtg gat tct gca cca cgg ccc tcc gaa aag aat 2064 Leu Asn Leu Lys Asp Val Asp Ser Ala Pro Arg Pro Ser Glu Lys Asn 675 680 685 ctt aca aga aca agt gtt agc ttt att gga tga 2097 Leu Thr Arg Thr Ser Val Ser Phe Ile Gly 690 695 <210> 20 <211> 698 <212> PRT <213> Saccharomyces cerevisiae <400> 20 Met Val Phe Ser Tyr Glu His Tyr Met Asn Leu Leu Phe His Leu Asp 1 5 10 15 Asn Ser Lys Glu Thr Val Pro Pro Glu Ile Ala Lys Arg Ile Ile Ser 20 25 30 Asn Ala Ile Ala Pro Val Ile Thr Val Thr Ser Thr Pro Leu Phe Asp 35 40 45 Page 34 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys His Ile Gln Glu Thr Tyr Lys Val Asp Ser Leu Tyr Met Leu Leu 50 55 60 Arg Phe Phe Gly Gly Cys Val Ser Asp Arg Asp Gln Ala Asn Glu Ala 65 70 75 80 Lys Val Gly Gln His Glu His Glu Val Cys Asp Ala Ser Asp Ser Thr 85 90 95 Asp Ser Ile Pro Lys Asn Lys Asn Leu Glu Val Pro Asn Leu Ser Lys 100 105 110 Lys Gly Ser Arg Ser Arg Ser Asn Ser Leu Phe Gln Arg Asp Ser Thr 115 120 125 Gln Ser Gln Tyr Ile Arg Phe Thr Arg Pro Leu Gly Asp Leu Ile Glu 130 135 140 Thr Arg Asp Ala Asn Asp Met Leu Phe Asn Tyr His Ser Leu Glu Val 145 150 155 160 Phe Leu Asp Asn Tyr Leu Lys Leu Val Ala Ala Asn Thr Asp Glu Met 165 170 175 Val Pro His Asn Leu Leu Lys Lys Ser Ile Tyr His Ser Phe Phe Ser 180 185 190 Leu Ala Ile Ser Ser Thr Asn Asn Leu Ser Pro Tyr Glu Thr Phe Asn 195 200 205 His Pro Ile Leu Ser Leu Ile Ala Leu Asp Ile Ser Asn Gly Glu Val 210 215 220 Tyr Glu Asp Ala Arg Asp Leu Leu Val Asn Phe Lys Asn Leu Asn His 225 230 235 240 Asn Thr Glu Asn Phe Pro Ile Phe Met Asn Thr Asn Glu Met Leu Pro 245 250 255 Val Phe Leu Leu Cys Tyr Asn Asp Asp Ser Gln Glu Glu Phe Glu Lys 260 265 270 Cys Gln Ala Leu Ala Lys Lys Leu Lys Lys Gln Leu Phe Val Glu Ser 275 280 285 Ile Leu Leu Ala Leu Trp Lys Asp Ser Phe Ile Tyr Asp Glu Asn Ser 290 295 300 Val Ile Gln Leu His Gln Pro Val Met Ser Ser Leu Glu Glu Ile Leu 305 310 315 320 Page 35 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Phe Leu Gln Ala Pro Thr Gln Thr Thr Leu Ser Leu Ala Leu Ile 325 330 335 Asn Ser Ile Tyr Asp Met Leu Asp Tyr Leu Val Tyr Asp Leu Met Ile 340 345 350 Pro Phe Met Lys Arg Lys Val Ser Phe Trp Glu Glu Thr Ile Leu Gln 355 360 365 Pro Arg Lys Ser Leu Phe Asn Gly Ala Lys Phe Phe Lys Lys Phe Met 370 375 380 Asn Lys Asn Pro Val Asn Gly Asn His Gln His Asn Ser Leu Thr Arg 385 390 395 400 Asp Ser Gln Gly Asn Glu Tyr Phe Ala Ser Ser Ser Ser Glu Phe Leu 405 410 415 Met Arg Lys Leu Ala Asp Trp Ser Met Met Leu Ser Asp Phe Lys Thr 420 425 430 Ala Tyr Ser Thr Tyr Glu Ser Leu Met Asp Asp Leu Asp Ala Phe Pro 435 440 445 Lys Tyr Leu Ala Ser Cys Ile Glu Trp Cys Ala Val Ser Leu Leu Met 450 455 460 Gly Ala Gln Ser Ile Val Thr Val Lys Met Ile Lys Asn Asp Ile Asn 465 470 475 480 Pro Leu Ile Glu Arg Ala Leu Ala Thr Tyr Glu Asn Cys Ser Arg Ile 485 490 495 Gln Arg Gly Lys Gly Lys Glu Ser Asn Ser Leu Asp Val Thr Glu Pro 500 505 510 Val Arg Ser Tyr Glu Thr Arg Cys Met Ile Leu Ala Ser Glu Leu Phe 515 520 525 Leu Ser Leu Ser Asn Thr Trp Thr Ser Thr Pro Tyr Ala Ile Gln Tyr 530 535 540 Leu Glu Thr Ile Leu Asp Glu Cys Lys Leu Gly Pro Cys Ser Gln Ile 545 550 555 560 Met Val Trp Glu Arg Leu Ser Asp Cys Tyr Asn Leu Arg Val Asp Pro 565 570 575 Arg Ile Lys His Arg Val Gly Ala Met Lys Lys Asp Ala Lys Asp Thr 580 585 590 Page 36 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Asp Leu Arg Gly Glu His Lys Tyr Ser Thr Asp His Phe Thr Asp 595 600 605 Glu Asp Ile Leu Ser Glu Gly Leu Thr Arg Arg Arg Lys Ala Ala Phe 610 615 620 Phe Arg Leu Ile Ala Ala Lys Lys Trp Ala Glu Gln Lys Gln Trp Arg 625 630 635 640 Gln Val Ser Trp Cys Leu Lys Asp Ile Glu Ser Thr Tyr Ser Glu Ile 645 650 655 Lys Phe Leu His Gly Asn Gly Leu Ile Leu Ser Lys Leu Lys Asn Gln 660 665 670 Leu Asn Leu Lys Asp Val Asp Ser Ala Pro Arg Pro Ser Glu Lys Asn 675 680 685 Leu Thr Arg Thr Ser Val Ser Phe Ile Gly 690 695 <210> 21 <211> 327 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(327) <400> 21 atg cga tat act gca act ttt cgg cct ttg caa cga ttt gta atg aat 48 Met Arg Tyr Thr Ala Thr Phe Arg Pro Leu Gln Arg Phe Val Met Asn 1 5 10 15 cct ttt gca tcg cta gaa gga caa gat aat att tct tct gtt ttt ttt 96 Pro Phe Ala Ser Leu Glu Gly Gln Asp Asn Ile Ser Ser Val Phe Phe 20 25 30 tta cat atg caa caa ttt gaa agt cag gtc aaa gac aga ttc cgg ttc 144 Leu His Met Gln Gln Phe Glu Ser Gln Val Lys Asp Arg Phe Arg Phe 35 40 45 ccc ata ttc aga ttg gag aga aaa act ttt ggc aac tca tgt tac caa 192 Pro Ile Phe Arg Leu Glu Arg Lys Thr Phe Gly Asn Ser Cys Tyr Gln 50 55 60 gtc gag acg ctt aaa gtt aag tgt cgg cca aga cac gca aaa tct tgt 240 Val Glu Thr Leu Lys Val Lys Cys Arg Pro Arg His Ala Lys Ser Cys 65 70 75 80 aat ctt tta acg ctg ctc ttc aaa tca cgg acg caa tca gta ctt gta 288 Asn Leu Leu Thr Leu Leu Phe Lys Ser Arg Thr Gln Ser Val Leu Val 85 90 95 cct aat ttt ggt ttt cta ata ttg aat agc gaa cca tag 327 Pro Asn Phe Gly Phe Leu Ile Leu Asn Ser Glu Pro Page 37 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 100 105 <210> 22 <211> 108 <212> PRT <213> Saccharomyces cerevisiae <400> 22 Met Arg Tyr Thr Ala Thr Phe Arg Pro Leu Gln Arg Phe Val Met Asn 1 5 10 15 Pro Phe Ala Ser Leu Glu Gly Gln Asp Asn Ile Ser Ser Val Phe Phe 20 25 30 Leu His Met Gln Gln Phe Glu Ser Gln Val Lys Asp Arg Phe Arg Phe 35 40 45 Pro Ile Phe Arg Leu Glu Arg Lys Thr Phe Gly Asn Ser Cys Tyr Gln 50 55 60 Val Glu Thr Leu Lys Val Lys Cys Arg Pro Arg His Ala Lys Ser Cys 65 70 75 80 Asn Leu Leu Thr Leu Leu Phe Lys Ser Arg Thr Gln Ser Val Leu Val 85 90 95 Pro Asn Phe Gly Phe Leu Ile Leu Asn Ser Glu Pro 100 105 <210> 23 <211> 411 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(411) <400> 23 atg caa ttc tct acc gtc gct tct atc gct gct att gcc gct gtt gcc 48 Met Gln Phe Ser Thr Val Ala Ser Ile Ala Ala Ile Ala Ala Val Ala 1 5 10 15 tcc gcc gct tct aac att acc act gct act gtc aca gaa gaa tct acc 96 Ser Ala Ala Ser Asn Ile Thr Thr Ala Thr Val Thr Glu Glu Ser Thr 20 25 30 act ttg gtc act atc act tct tgt gag gac cac gtt tgt tct gaa aca 144 Thr Leu Val Thr Ile Thr Ser Cys Glu Asp His Val Cys Ser Glu Thr 35 40 45 gtt tcc cca gct ttg gtt tcc act gct acc gtc acc gta aat gac gtt 192 Val Ser Pro Ala Leu Val Ser Thr Ala Thr Val Thr Val Asn Asp Val 50 55 60 atc act taa tac acc acc tgg tgt cca ttg cca acc act gaa gca cca 240 Ile Thr Tyr Thr Thr Trp Cys Pro Leu Pro Thr Thr Glu Ala Pro 65 70 75 Page 38 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag aat acc act tct cca gct cca act gaa aag cca acc gaa aag cca 288 Lys Asn Thr Thr Ser Pro Ala Pro Thr Glu Lys Pro Thr Glu Lys Pro 80 85 90 95 act gaa aag cca acc caa caa ggt tct agc act caa act gtt acc tcc 336 Thr Glu Lys Pro Thr Gln Gln Gly Ser Ser Thr Gln Thr Val Thr Ser 100 105 110 tac act ggt gcc gct gtt aag gct ttg cca gct gcc ggt gct ttg ttg 384 Tyr Thr Gly Ala Ala Val Lys Ala Leu Pro Ala Ala Gly Ala Leu Leu 115 120 125 gct ggt gct gcc gct tta ttg ttg taa 411 Ala Gly Ala Ala Ala Leu Leu Leu 130 135 <210> 24 <211> 66 <212> PRT <213> Saccharomyces cerevisiae <400> 24 Met Gln Phe Ser Thr Val Ala Ser Ile Ala Ala Ile Ala Ala Val Ala 1 5 10 15 Ser Ala Ala Ser Asn Ile Thr Thr Ala Thr Val Thr Glu Glu Ser Thr 20 25 30 Thr Leu Val Thr Ile Thr Ser Cys Glu Asp His Val Cys Ser Glu Thr 35 40 45 Val Ser Pro Ala Leu Val Ser Thr Ala Thr Val Thr Val Asn Asp Val 50 55 60 Ile Thr 65 <210> 25 <211> 69 <212> PRT <213> Saccharomyces cerevisiae <400> 25 Tyr Thr Thr Trp Cys Pro Leu Pro Thr Thr Glu Ala Pro Lys Asn Thr 1 5 10 15 Thr Ser Pro Ala Pro Thr Glu Lys Pro Thr Glu Lys Pro Thr Glu Lys 20 25 30 Pro Thr Gln Gln Gly Ser Ser Thr Gln Thr Val Thr Ser Tyr Thr Gly 35 40 45 Ala Ala Val Lys Ala Leu Pro Ala Ala Gly Ala Leu Leu Ala Gly Ala 50 55 60 Page 39 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Ala Leu Leu Leu 65 <210> 26 <211> 693 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(693) <400> 26 atg gaa atg act gat ttt gaa cta act agt aat tcg caa tcg aac ttg 48 Met Glu Met Thr Asp Phe Glu Leu Thr Ser Asn Ser Gln Ser Asn Leu 1 5 10 15 gct atc cct acc aac ttc aag tcg act ctg cct cca agg aaa aga gcc 96 Ala Ile Pro Thr Asn Phe Lys Ser Thr Leu Pro Pro Arg Lys Arg Ala 20 25 30 aag aca aaa gag gaa aag gaa cag cga agg atc gag cgt att ttg aga 144 Lys Thr Lys Glu Glu Lys Glu Gln Arg Arg Ile Glu Arg Ile Leu Arg 35 40 45 aac aga aga gct gct cac cag agc aga gag aaa aaa aga cta cat ctg 192 Asn Arg Arg Ala Ala His Gln Ser Arg Glu Lys Lys Arg Leu His Leu 50 55 60 cag tat ctc gag aga aaa tgt tct ctt ttg gaa aat tta ctg aac agc 240 Gln Tyr Leu Glu Arg Lys Cys Ser Leu Leu Glu Asn Leu Leu Asn Ser 65 70 75 80 gtc aac ctt gaa aaa ctg gct gac cac gaa gac gcg ttg act tgc agc 288 Val Asn Leu Glu Lys Leu Ala Asp His Glu Asp Ala Leu Thr Cys Ser 85 90 95 cac gac gct ttt gtt gct tct ctt gac gag tac agg gat ttc cag agc 336 His Asp Ala Phe Val Ala Ser Leu Asp Glu Tyr Arg Asp Phe Gln Ser 100 105 110 acg agg ggc gct tca ctg gac acc agg gcc agt tcg cac tcg tcg tct 384 Thr Arg Gly Ala Ser Leu Asp Thr Arg Ala Ser Ser His Ser Ser Ser 115 120 125 gat acg ttc aca cct tca cct ctg aac tgt aca atg gag cct gcg act 432 Asp Thr Phe Thr Pro Ser Pro Leu Asn Cys Thr Met Glu Pro Ala Thr 130 135 140 ttg tcg ccc aag agt atg cgc gat tcc gcg tcg gac caa gag act tca 480 Leu Ser Pro Lys Ser Met Arg Asp Ser Ala Ser Asp Gln Glu Thr Ser 145 150 155 160 tgg gag ctg cag atg ttt aag acg gaa aat gta cca gag tcg acg acg 528 Trp Glu Leu Gln Met Phe Lys Thr Glu Asn Val Pro Glu Ser Thr Thr 165 170 175 cta cct gcc gta gac aac aac aat ttg ttt gat gcg gtg gcc tcg ccg 576 Leu Pro Ala Val Asp Asn Asn Asn Leu Phe Asp Ala Val Ala Ser Pro 180 185 190 ttg gca gac cca ctc tgc gac gat ata gcg gga aac agt cta ccc ttt 624 Leu Ala Asp Pro Leu Cys Asp Asp Ile Ala Gly Asn Ser Leu Pro Phe 195 200 205 gac aat tca att gat ctt gac aat tgg cgt aat cca gcc gtg att acg 672 Page 40 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Asn Ser Ile Asp Leu Asp Asn Trp Arg Asn Pro Ala Val Ile Thr 210 215 220 atg acc agg aaa cta cag tga 693 Met Thr Arg Lys Leu Gln 225 230 <210> 27 <211> 230 <212> PRT <213> Saccharomyces cerevisiae <400> 27 Met Glu Met Thr Asp Phe Glu Leu Thr Ser Asn Ser Gln Ser Asn Leu 1 5 10 15 Ala Ile Pro Thr Asn Phe Lys Ser Thr Leu Pro Pro Arg Lys Arg Ala 20 25 30 Lys Thr Lys Glu Glu Lys Glu Gln Arg Arg Ile Glu Arg Ile Leu Arg 35 40 45 Asn Arg Arg Ala Ala His Gln Ser Arg Glu Lys Lys Arg Leu His Leu 50 55 60 Gln Tyr Leu Glu Arg Lys Cys Ser Leu Leu Glu Asn Leu Leu Asn Ser 65 70 75 80 Val Asn Leu Glu Lys Leu Ala Asp His Glu Asp Ala Leu Thr Cys Ser 85 90 95 His Asp Ala Phe Val Ala Ser Leu Asp Glu Tyr Arg Asp Phe Gln Ser 100 105 110 Thr Arg Gly Ala Ser Leu Asp Thr Arg Ala Ser Ser His Ser Ser Ser 115 120 125 Asp Thr Phe Thr Pro Ser Pro Leu Asn Cys Thr Met Glu Pro Ala Thr 130 135 140 Leu Ser Pro Lys Ser Met Arg Asp Ser Ala Ser Asp Gln Glu Thr Ser 145 150 155 160 Trp Glu Leu Gln Met Phe Lys Thr Glu Asn Val Pro Glu Ser Thr Thr 165 170 175 Leu Pro Ala Val Asp Asn Asn Asn Leu Phe Asp Ala Val Ala Ser Pro 180 185 190 Leu Ala Asp Pro Leu Cys Asp Asp Ile Ala Gly Asn Ser Leu Pro Phe 195 200 205 Asp Asn Ser Ile Asp Leu Asp Asn Trp Arg Asn Pro Ala Val Ile Thr Page 41 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 210 215 220 Met Thr Arg Lys Leu Gln 225 230 <210> 28 <211> 1398 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1398) <400> 28 atg gcc cgc aat aga caa gcg tgc gac tgt tgt tgc att cgt cga gta 48 Met Ala Arg Asn Arg Gln Ala Cys Asp Cys Cys Cys Ile Arg Arg Val 1 5 10 15 aag tgt gat cgt aaa aaa cca tgt aaa tgt tgt ctt caa cac aat ctg 96 Lys Cys Asp Arg Lys Lys Pro Cys Lys Cys Cys Leu Gln His Asn Leu 20 25 30 caa tgt aca tat ctt cga cct ttg aag aaa aga ggt cca aaa ccc gtc 144 Gln Cys Thr Tyr Leu Arg Pro Leu Lys Lys Arg Gly Pro Lys Pro Val 35 40 45 aag gtg aga aat tta aag aaa gta gat gat gta cag gta ttt agt aaa 192 Lys Val Arg Asn Leu Lys Lys Val Asp Asp Val Gln Val Phe Ser Lys 50 55 60 agt agt agt ggt ggc ata atg aag gtt cca aag gca cta att gat cag 240 Ser Ser Ser Gly Gly Ile Met Lys Val Pro Lys Ala Leu Ile Asp Gln 65 70 75 80 tgt ctg cgg ctc tat aat gat aag ttg tat gtg atc tgg cct ttg ctg 288 Cys Leu Arg Leu Tyr Asn Asp Lys Leu Tyr Val Ile Trp Pro Leu Leu 85 90 95 tgt tat gat gat ctt tac gaa ctt tta gag aaa aga tat gac gaa acc 336 Cys Tyr Asp Asp Leu Tyr Glu Leu Leu Glu Lys Arg Tyr Asp Glu Thr 100 105 110 tgt gtg tat tgg ttc ctg gta tct ctt tct gcc gcc acg ctt agc gat 384 Cys Val Tyr Trp Phe Leu Val Ser Leu Ser Ala Ala Thr Leu Ser Asp 115 120 125 ttg cag act gaa att gag tcg gaa gga ggg gtt acc ttt act ggg ata 432 Leu Gln Thr Glu Ile Glu Ser Glu Gly Gly Val Thr Phe Thr Gly Ile 130 135 140 cag tta tcc agt ttc tgc atg tca tca cgc caa gaa ttt gac gat ttt 480 Gln Leu Ser Ser Phe Cys Met Ser Ser Arg Gln Glu Phe Asp Asp Phe 145 150 155 160 aac ggt agt gat ata ttc aag att atg acg tac tat tgt cta aac cgc 528 Asn Gly Ser Asp Ile Phe Lys Ile Met Thr Tyr Tyr Cys Leu Asn Arg 165 170 175 tgc tac gca cag atg tcc aac tca aga act tcg tat cgg ctt tct tgt 576 Cys Tyr Ala Gln Met Ser Asn Ser Arg Thr Ser Tyr Arg Leu Ser Cys 180 185 190 gaa gcc gtg ggg ctc att aag ttg gcg ggg ttc cat cgc gag gaa act 624 Glu Ala Val Gly Leu Ile Lys Leu Ala Gly Phe His Arg Glu Glu Thr Page 42 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 195 200 205 ttg aaa ctt ctt cct ttc gat gag cag cag ctt gga agg aaa gtt tat 672 Leu Lys Leu Leu Pro Phe Asp Glu Gln Gln Leu Gly Arg Lys Val Tyr 210 215 220 tat ttg ctt ctc tta acg gaa aga tac ttt tct gtg tat acg cat tgc 720 Tyr Leu Leu Leu Leu Thr Glu Arg Tyr Phe Ser Val Tyr Thr His Cys 225 230 235 240 gcc acg agc ctg gat acc acg att gct cca cca caa ccg gag aac gta 768 Ala Thr Ser Leu Asp Thr Thr Ile Ala Pro Pro Gln Pro Glu Asn Val 245 250 255 acg gac ccc cga cta tct ctc gac agc ttc ttg gag atg att agg gta 816 Thr Asp Pro Arg Leu Ser Leu Asp Ser Phe Leu Glu Met Ile Arg Val 260 265 270 ttt act gta ccg gga aaa tgc ttc ttt gat gct cta gct acc gac tct 864 Phe Thr Val Pro Gly Lys Cys Phe Phe Asp Ala Leu Ala Thr Asp Ser 275 280 285 gct aat gta acc tgt act gaa gac tcc ctt aaa aag ata tgg agg gaa 912 Ala Asn Val Thr Cys Thr Glu Asp Ser Leu Lys Lys Ile Trp Arg Glu 290 295 300 ctt cat acg gtg cca ctt gag ata gaa cca tgg tct tac ggc tat gta 960 Leu His Thr Val Pro Leu Glu Ile Glu Pro Trp Ser Tyr Gly Tyr Val 305 310 315 320 gac ata tct ttt tca cgg cat tgg att aga aca ctt gct tgg aag cta 1008 Asp Ile Ser Phe Ser Arg His Trp Ile Arg Thr Leu Ala Trp Lys Leu 325 330 335 gtg ctt caa ata agc ggt atg cga atc agt ttc ctt tca aat agc aag 1056 Val Leu Gln Ile Ser Gly Met Arg Ile Ser Phe Leu Ser Asn Ser Lys 340 345 350 aat acg cat att cca gta gaa att gct aga gac atg tta gaa gac aca 1104 Asn Thr His Ile Pro Val Glu Ile Ala Arg Asp Met Leu Glu Asp Thr 355 360 365 ttt tta atc cca aaa aat ctt tat gca gtt cac ggt cca ggg ata tca 1152 Phe Leu Ile Pro Lys Asn Leu Tyr Ala Val His Gly Pro Gly Ile Ser 370 375 380 gtg aaa gca cta gaa ata gcc gac gca ttg gta gat gtt gtg aat cag 1200 Val Lys Ala Leu Glu Ile Ala Asp Ala Leu Val Asp Val Val Asn Gln 385 390 395 400 tac gat caa aat gca gag tcg gag gct tgg aat ttt ttg ttc gat ata 1248 Tyr Asp Gln Asn Ala Glu Ser Glu Ala Trp Asn Phe Leu Phe Asp Ile 405 410 415 tcc aaa ttt gtc ttc tct ctt aag cat tgt gat agc aca tta gtt gat 1296 Ser Lys Phe Val Phe Ser Leu Lys His Cys Asp Ser Thr Leu Val Asp 420 425 430 aag ttt acg aca aag tgt cag tgt gcg ctt atc acg ctt cct ctt tct 1344 Lys Phe Thr Thr Lys Cys Gln Cys Ala Leu Ile Thr Leu Pro Leu Ser 435 440 445 aat ccg ctt gaa tcg aca gat ggt tct aaa gaa gat gta gat gcg ctt 1392 Asn Pro Leu Glu Ser Thr Asp Gly Ser Lys Glu Asp Val Asp Ala Leu 450 455 460 cct taa 1398 Pro Page 43 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 465 <210> 29 <211> 465 <212> PRT <213> Saccharomyces cerevisiae <400> 29 Met Ala Arg Asn Arg Gln Ala Cys Asp Cys Cys Cys Ile Arg Arg Val 1 5 10 15 Lys Cys Asp Arg Lys Lys Pro Cys Lys Cys Cys Leu Gln His Asn Leu 20 25 30 Gln Cys Thr Tyr Leu Arg Pro Leu Lys Lys Arg Gly Pro Lys Pro Val 35 40 45 Lys Val Arg Asn Leu Lys Lys Val Asp Asp Val Gln Val Phe Ser Lys 50 55 60 Ser Ser Ser Gly Gly Ile Met Lys Val Pro Lys Ala Leu Ile Asp Gln 65 70 75 80 Cys Leu Arg Leu Tyr Asn Asp Lys Leu Tyr Val Ile Trp Pro Leu Leu 85 90 95 Cys Tyr Asp Asp Leu Tyr Glu Leu Leu Glu Lys Arg Tyr Asp Glu Thr 100 105 110 Cys Val Tyr Trp Phe Leu Val Ser Leu Ser Ala Ala Thr Leu Ser Asp 115 120 125 Leu Gln Thr Glu Ile Glu Ser Glu Gly Gly Val Thr Phe Thr Gly Ile 130 135 140 Gln Leu Ser Ser Phe Cys Met Ser Ser Arg Gln Glu Phe Asp Asp Phe 145 150 155 160 Asn Gly Ser Asp Ile Phe Lys Ile Met Thr Tyr Tyr Cys Leu Asn Arg 165 170 175 Cys Tyr Ala Gln Met Ser Asn Ser Arg Thr Ser Tyr Arg Leu Ser Cys 180 185 190 Glu Ala Val Gly Leu Ile Lys Leu Ala Gly Phe His Arg Glu Glu Thr 195 200 205 Leu Lys Leu Leu Pro Phe Asp Glu Gln Gln Leu Gly Arg Lys Val Tyr 210 215 220 Tyr Leu Leu Leu Leu Thr Glu Arg Tyr Phe Ser Val Tyr Thr His Cys 225 230 235 240 Page 44 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Thr Ser Leu Asp Thr Thr Ile Ala Pro Pro Gln Pro Glu Asn Val 245 250 255 Thr Asp Pro Arg Leu Ser Leu Asp Ser Phe Leu Glu Met Ile Arg Val 260 265 270 Phe Thr Val Pro Gly Lys Cys Phe Phe Asp Ala Leu Ala Thr Asp Ser 275 280 285 Ala Asn Val Thr Cys Thr Glu Asp Ser Leu Lys Lys Ile Trp Arg Glu 290 295 300 Leu His Thr Val Pro Leu Glu Ile Glu Pro Trp Ser Tyr Gly Tyr Val 305 310 315 320 Asp Ile Ser Phe Ser Arg His Trp Ile Arg Thr Leu Ala Trp Lys Leu 325 330 335 Val Leu Gln Ile Ser Gly Met Arg Ile Ser Phe Leu Ser Asn Ser Lys 340 345 350 Asn Thr His Ile Pro Val Glu Ile Ala Arg Asp Met Leu Glu Asp Thr 355 360 365 Phe Leu Ile Pro Lys Asn Leu Tyr Ala Val His Gly Pro Gly Ile Ser 370 375 380 Val Lys Ala Leu Glu Ile Ala Asp Ala Leu Val Asp Val Val Asn Gln 385 390 395 400 Tyr Asp Gln Asn Ala Glu Ser Glu Ala Trp Asn Phe Leu Phe Asp Ile 405 410 415 Ser Lys Phe Val Phe Ser Leu Lys His Cys Asp Ser Thr Leu Val Asp 420 425 430 Lys Phe Thr Thr Lys Cys Gln Cys Ala Leu Ile Thr Leu Pro Leu Ser 435 440 445 Asn Pro Leu Glu Ser Thr Asp Gly Ser Lys Glu Asp Val Asp Ala Leu 450 455 460 Pro 465 <210> 30 <211> 2025 <212> DNA <213> Saccharomyces cerevisiae Page 45 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(2025) <400> 30 atg tcg gat gta gat aac tgg gaa ccc gta tca gat aat gag gac agt 48 Met Ser Asp Val Asp Asn Trp Glu Pro Val Ser Asp Asn Glu Asp Ser 1 5 10 15 act gat tct gtg aaa caa ttg ggt ccc ccc ttt gag cat gca agt aac 96 Thr Asp Ser Val Lys Gln Leu Gly Pro Pro Phe Glu His Ala Ser Asn 20 25 30 aat gac aat gcc ggc gat act gaa gct gag tca ctg caa gaa gtg ccc 144 Asn Asp Asn Ala Gly Asp Thr Glu Ala Glu Ser Leu Gln Glu Val Pro 35 40 45 cta aat aca gag acc aac gac gta cgc aag aat tta gta gtg att aca 192 Leu Asn Thr Glu Thr Asn Asp Val Arg Lys Asn Leu Val Val Ile Thr 50 55 60 aac caa agt gcc gcc gat gaa cac cct aca gag atc aag cac gat caa 240 Asn Gln Ser Ala Ala Asp Glu His Pro Thr Glu Ile Lys His Asp Gln 65 70 75 80 tca agg act tct tcg acg tcc tcg ttc ttc agt gga atg atc tct tcg 288 Ser Arg Thr Ser Ser Thr Ser Ser Phe Phe Ser Gly Met Ile Ser Ser 85 90 95 ttt aag tca aac gtg cca tcc cca gtt tct aga tca act acg cca act 336 Phe Lys Ser Asn Val Pro Ser Pro Val Ser Arg Ser Thr Thr Pro Thr 100 105 110 tcg cca gtt tcg caa cca agc att ata tca cat aga agg gag cct tcc 384 Ser Pro Val Ser Gln Pro Ser Ile Ile Ser His Arg Arg Glu Pro Ser 115 120 125 atg ggg tcc aaa aga aga tca agc cgc cgt atc agt aat gcc aca att 432 Met Gly Ser Lys Arg Arg Ser Ser Arg Arg Ile Ser Asn Ala Thr Ile 130 135 140 gct gaa ata ggc tct ccc ttg caa cag gtg gaa aag cct gat gag gtc 480 Ala Glu Ile Gly Ser Pro Leu Gln Gln Val Glu Lys Pro Asp Glu Val 145 150 155 160 aag aca aga ctc act cct tcc caa atg aaa gaa gac aat tac gat cat 528 Lys Thr Arg Leu Thr Pro Ser Gln Met Lys Glu Asp Asn Tyr Asp His 165 170 175 aga cga ttc gtg gaa gaa cgt tac atg gac aca cct tat cac tat gcg 576 Arg Arg Phe Val Glu Glu Arg Tyr Met Asp Thr Pro Tyr His Tyr Ala 180 185 190 tct gag caa aga aat aaa gac ttt cat gag aca ttc aag tcc gtt cct 624 Ser Glu Gln Arg Asn Lys Asp Phe His Glu Thr Phe Lys Ser Val Pro 195 200 205 aaa gat gac aga cta ctg gat gat ttt aat tgt ggg ctg aat aga gag 672 Lys Asp Asp Arg Leu Leu Asp Asp Phe Asn Cys Gly Leu Asn Arg Glu 210 215 220 ctg ctt tac cag ggg aaa cta tac ata aca gaa acg cat ctc tgc ttc 720 Leu Leu Tyr Gln Gly Lys Leu Tyr Ile Thr Glu Thr His Leu Cys Phe 225 230 235 240 aac tcc aat gtt ctt ggt tgg att gct aaa gta ctg att gcg ttc gaa 768 Asn Ser Asn Val Leu Gly Trp Ile Ala Lys Val Leu Ile Ala Phe Glu Page 46 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 245 250 255 gat gtc acg ttt atg gaa aaa act tct gct gct ggg ttg ttc ccc agc 816 Asp Val Thr Phe Met Glu Lys Thr Ser Ala Ala Gly Leu Phe Pro Ser 260 265 270 gca ata tcc atc gaa aca aag atg ggc aaa act ctc ttt aat ggt ttt 864 Ala Ile Ser Ile Glu Thr Lys Met Gly Lys Thr Leu Phe Asn Gly Phe 275 280 285 ata tcc agg gat gct gca ttt gga tta atg aaa gaa gtg tgg tca aga 912 Ile Ser Arg Asp Ala Ala Phe Gly Leu Met Lys Glu Val Trp Ser Arg 290 295 300 acc ttg ttg cag aag gac atg gcc agc gaa aac atc aat act aaa gca 960 Thr Leu Leu Gln Lys Asp Met Ala Ser Glu Asn Ile Asn Thr Lys Ala 305 310 315 320 gaa aag tca gga aat ggc aaa gag att gat gat gca ata aac tcc atc 1008 Glu Lys Ser Gly Asn Gly Lys Glu Ile Asp Asp Ala Ile Asn Ser Ile 325 330 335 gat gag gaa aac aat gat aaa gac gct aat gat aat gac act aat gaa 1056 Asp Glu Glu Asn Asn Asp Lys Asp Ala Asn Asp Asn Asp Thr Asn Glu 340 345 350 aat gac gat gaa aat atc tct aca aat gag act acc ccc aat agt acg 1104 Asn Asp Asp Glu Asn Ile Ser Thr Asn Glu Thr Thr Pro Asn Ser Thr 355 360 365 agt tcc tcg ccg gat aaa gaa aaa gag aaa gcg tat aaa ctg cgt gcc 1152 Ser Ser Ser Pro Asp Lys Glu Lys Glu Lys Ala Tyr Lys Leu Arg Ala 370 375 380 gat tcc tcg tat cag tat gat ggt cca ata tat cat cat tca aca agc 1200 Asp Ser Ser Tyr Gln Tyr Asp Gly Pro Ile Tyr His His Ser Thr Ser 385 390 395 400 ttt ccg gct gaa cct atg gcc aat aac gag ttt gtt ctc aag gag tta 1248 Phe Pro Ala Glu Pro Met Ala Asn Asn Glu Phe Val Leu Lys Glu Leu 405 410 415 cca ttc gat tgt gca cct ggt ata ctt ttt gag atc atg ttc aac tca 1296 Pro Phe Asp Cys Ala Pro Gly Ile Leu Phe Glu Ile Met Phe Asn Ser 420 425 430 gag caa aac gaa ttt ctt cta gat ttt tta cgg ggt caa gaa ggt tca 1344 Glu Gln Asn Glu Phe Leu Leu Asp Phe Leu Arg Gly Gln Glu Gly Ser 435 440 445 caa att acc act att cca aat ttc acg agc att gac gga tct tcc atg 1392 Gln Ile Thr Thr Ile Pro Asn Phe Thr Ser Ile Asp Gly Ser Ser Met 450 455 460 act ttg aag cgt gag tat tca tac gag aaa gca ttg cac ttt cct gcg 1440 Thr Leu Lys Arg Glu Tyr Ser Tyr Glu Lys Ala Leu His Phe Pro Ala 465 470 475 480 ggg ccc aag tcc acg aca tgt tat gtt gct gag gta ata aag aga aaa 1488 Gly Pro Lys Ser Thr Thr Cys Tyr Val Ala Glu Val Ile Lys Arg Lys 485 490 495 gat cct gat act tac tat gag gtt atc agt agc ata cgc act ccg aac 1536 Asp Pro Asp Thr Tyr Tyr Glu Val Ile Ser Ser Ile Arg Thr Pro Asn 500 505 510 gtg ccc agt ggt ggt agt ttc tca act aag aca agg tat cta atc cgt 1584 Val Pro Ser Gly Gly Ser Phe Ser Thr Lys Thr Arg Tyr Leu Ile Arg Page 47 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 515 520 525 tgg aat gac gaa ata acg tgt ctg tta cgg gta tcc ttt tgg gtg gaa 1632 Trp Asn Asp Glu Ile Thr Cys Leu Leu Arg Val Ser Phe Trp Val Glu 530 535 540 tgg act ggt tcc agt tgg atc aaa ggt atg gtt gaa aat gga tgc aag 1680 Trp Thr Gly Ser Ser Trp Ile Lys Gly Met Val Glu Asn Gly Cys Lys 545 550 555 560 aat ggt caa ttg gag gct gcg caa tta atg gag cgt att ctt tcc aag 1728 Asn Gly Gln Leu Glu Ala Ala Gln Leu Met Glu Arg Ile Leu Ser Lys 565 570 575 ttc atc aag aac aat gtc gaa gag tgc caa att act atc agc aag gag 1776 Phe Ile Lys Asn Asn Val Glu Glu Cys Gln Ile Thr Ile Ser Lys Glu 580 585 590 gaa gag gag caa gat gat aaa gaa gta aaa aat aag ttg aaa gag gtt 1824 Glu Glu Glu Gln Asp Asp Lys Glu Val Lys Asn Lys Leu Lys Glu Val 595 600 605 gac ctt gaa caa cca aga gaa gcg gtt gtt acg gct ccc gca att gca 1872 Asp Leu Glu Gln Pro Arg Glu Ala Val Val Thr Ala Pro Ala Ile Ala 610 615 620 gag cag caa ggt ctc aag gtc acc atg gaa aca tgg ttg ttc tta tac 1920 Glu Gln Gln Gly Leu Lys Val Thr Met Glu Thr Trp Leu Phe Leu Tyr 625 630 635 640 ttg att gtg gtc gtt ttg cta ttg ttt aat ctg ttc tac ata cgt tca 1968 Leu Ile Val Val Val Leu Leu Leu Phe Asn Leu Phe Tyr Ile Arg Ser 645 650 655 att gct gtc tca tta cat caa ctg gtg aag ctg caa ttg gta gaa ctg 2016 Ile Ala Val Ser Leu His Gln Leu Val Lys Leu Gln Leu Val Glu Leu 660 665 670 aag ttg tga 2025 Lys Leu <210> 31 <211> 674 <212> PRT <213> Saccharomyces cerevisiae <400> 31 Met Ser Asp Val Asp Asn Trp Glu Pro Val Ser Asp Asn Glu Asp Ser 1 5 10 15 Thr Asp Ser Val Lys Gln Leu Gly Pro Pro Phe Glu His Ala Ser Asn 20 25 30 Asn Asp Asn Ala Gly Asp Thr Glu Ala Glu Ser Leu Gln Glu Val Pro 35 40 45 Leu Asn Thr Glu Thr Asn Asp Val Arg Lys Asn Leu Val Val Ile Thr 50 55 60 Asn Gln Ser Ala Ala Asp Glu His Pro Thr Glu Ile Lys His Asp Gln Page 48 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 65 70 75 80 Ser Arg Thr Ser Ser Thr Ser Ser Phe Phe Ser Gly Met Ile Ser Ser 85 90 95 Phe Lys Ser Asn Val Pro Ser Pro Val Ser Arg Ser Thr Thr Pro Thr 100 105 110 Ser Pro Val Ser Gln Pro Ser Ile Ile Ser His Arg Arg Glu Pro Ser 115 120 125 Met Gly Ser Lys Arg Arg Ser Ser Arg Arg Ile Ser Asn Ala Thr Ile 130 135 140 Ala Glu Ile Gly Ser Pro Leu Gln Gln Val Glu Lys Pro Asp Glu Val 145 150 155 160 Lys Thr Arg Leu Thr Pro Ser Gln Met Lys Glu Asp Asn Tyr Asp His 165 170 175 Arg Arg Phe Val Glu Glu Arg Tyr Met Asp Thr Pro Tyr His Tyr Ala 180 185 190 Ser Glu Gln Arg Asn Lys Asp Phe His Glu Thr Phe Lys Ser Val Pro 195 200 205 Lys Asp Asp Arg Leu Leu Asp Asp Phe Asn Cys Gly Leu Asn Arg Glu 210 215 220 Leu Leu Tyr Gln Gly Lys Leu Tyr Ile Thr Glu Thr His Leu Cys Phe 225 230 235 240 Asn Ser Asn Val Leu Gly Trp Ile Ala Lys Val Leu Ile Ala Phe Glu 245 250 255 Asp Val Thr Phe Met Glu Lys Thr Ser Ala Ala Gly Leu Phe Pro Ser 260 265 270 Ala Ile Ser Ile Glu Thr Lys Met Gly Lys Thr Leu Phe Asn Gly Phe 275 280 285 Ile Ser Arg Asp Ala Ala Phe Gly Leu Met Lys Glu Val Trp Ser Arg 290 295 300 Thr Leu Leu Gln Lys Asp Met Ala Ser Glu Asn Ile Asn Thr Lys Ala 305 310 315 320 Glu Lys Ser Gly Asn Gly Lys Glu Ile Asp Asp Ala Ile Asn Ser Ile 325 330 335 Asp Glu Glu Asn Asn Asp Lys Asp Ala Asn Asp Asn Asp Thr Asn Glu Page 49 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 340 345 350 Asn Asp Asp Glu Asn Ile Ser Thr Asn Glu Thr Thr Pro Asn Ser Thr 355 360 365 Ser Ser Ser Pro Asp Lys Glu Lys Glu Lys Ala Tyr Lys Leu Arg Ala 370 375 380 Asp Ser Ser Tyr Gln Tyr Asp Gly Pro Ile Tyr His His Ser Thr Ser 385 390 395 400 Phe Pro Ala Glu Pro Met Ala Asn Asn Glu Phe Val Leu Lys Glu Leu 405 410 415 Pro Phe Asp Cys Ala Pro Gly Ile Leu Phe Glu Ile Met Phe Asn Ser 420 425 430 Glu Gln Asn Glu Phe Leu Leu Asp Phe Leu Arg Gly Gln Glu Gly Ser 435 440 445 Gln Ile Thr Thr Ile Pro Asn Phe Thr Ser Ile Asp Gly Ser Ser Met 450 455 460 Thr Leu Lys Arg Glu Tyr Ser Tyr Glu Lys Ala Leu His Phe Pro Ala 465 470 475 480 Gly Pro Lys Ser Thr Thr Cys Tyr Val Ala Glu Val Ile Lys Arg Lys 485 490 495 Asp Pro Asp Thr Tyr Tyr Glu Val Ile Ser Ser Ile Arg Thr Pro Asn 500 505 510 Val Pro Ser Gly Gly Ser Phe Ser Thr Lys Thr Arg Tyr Leu Ile Arg 515 520 525 Trp Asn Asp Glu Ile Thr Cys Leu Leu Arg Val Ser Phe Trp Val Glu 530 535 540 Trp Thr Gly Ser Ser Trp Ile Lys Gly Met Val Glu Asn Gly Cys Lys 545 550 555 560 Asn Gly Gln Leu Glu Ala Ala Gln Leu Met Glu Arg Ile Leu Ser Lys 565 570 575 Phe Ile Lys Asn Asn Val Glu Glu Cys Gln Ile Thr Ile Ser Lys Glu 580 585 590 Glu Glu Glu Gln Asp Asp Lys Glu Val Lys Asn Lys Leu Lys Glu Val 595 600 605 Page 50 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Leu Glu Gln Pro Arg Glu Ala Val Val Thr Ala Pro Ala Ile Ala 610 615 620 Glu Gln Gln Gly Leu Lys Val Thr Met Glu Thr Trp Leu Phe Leu Tyr 625 630 635 640 Leu Ile Val Val Val Leu Leu Leu Phe Asn Leu Phe Tyr Ile Arg Ser 645 650 655 Ile Ala Val Ser Leu His Gln Leu Val Lys Leu Gln Leu Val Glu Leu 660 665 670 Lys Leu <210> 32 <211> 1185 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1185) <400> 32 atg cct cca aag aag caa gtc gaa gaa aaa aag gtc tta ttg ggt cgt 48 Met Pro Pro Lys Lys Gln Val Glu Glu Lys Lys Val Leu Leu Gly Arg 1 5 10 15 cca ggt aat aac ttg aaa gcc ggt att gtc ggt ttg gcc aat gtt ggt 96 Pro Gly Asn Asn Leu Lys Ala Gly Ile Val Gly Leu Ala Asn Val Gly 20 25 30 aag tct acc ttt ttc caa gcc atc act aga tgt cca ttg ggt aac cca 144 Lys Ser Thr Phe Phe Gln Ala Ile Thr Arg Cys Pro Leu Gly Asn Pro 35 40 45 gct aac tat cca ttc gct acc att gat cca gaa gaa gcc cgt gtt att 192 Ala Asn Tyr Pro Phe Ala Thr Ile Asp Pro Glu Glu Ala Arg Val Ile 50 55 60 gtc cca tct cca aga ttt gat aag ttg tgt gaa atc tac aag aag aca 240 Val Pro Ser Pro Arg Phe Asp Lys Leu Cys Glu Ile Tyr Lys Lys Thr 65 70 75 80 gct tcg gaa gtt cca gct cat ttg acc gtt tac gat att gct ggt ttg 288 Ala Ser Glu Val Pro Ala His Leu Thr Val Tyr Asp Ile Ala Gly Leu 85 90 95 act aag ggt gcc tct gct ggt gaa ggt ttg ggt aat gct ttc ttg tct 336 Thr Lys Gly Ala Ser Ala Gly Glu Gly Leu Gly Asn Ala Phe Leu Ser 100 105 110 cac atc aga tca gtc gat tct atc tac caa gtc gtt cgt tgt ttc gat 384 His Ile Arg Ser Val Asp Ser Ile Tyr Gln Val Val Arg Cys Phe Asp 115 120 125 gat gct gaa att atc cac gtt gag ggt gac gtt gat cca gtt cgt gat 432 Asp Ala Glu Ile Ile His Val Glu Gly Asp Val Asp Pro Val Arg Asp 130 135 140 tta gaa att att aac caa gaa cta aga ttg aaa gat att gaa ttc gca 480 Page 51 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Glu Ile Ile Asn Gln Glu Leu Arg Leu Lys Asp Ile Glu Phe Ala 145 150 155 160 caa aag gct ttg gaa ggt gct gaa aag att gcc aaa aga ggt ggt caa 528 Gln Lys Ala Leu Glu Gly Ala Glu Lys Ile Ala Lys Arg Gly Gly Gln 165 170 175 tct ttg gaa gtc aaa caa aag aag gaa gaa atg gat ttg att acg aaa 576 Ser Leu Glu Val Lys Gln Lys Lys Glu Glu Met Asp Leu Ile Thr Lys 180 185 190 atc att aaa ttg cta gag agt ggt caa aga gtt gct aat cac tcc tgg 624 Ile Ile Lys Leu Leu Glu Ser Gly Gln Arg Val Ala Asn His Ser Trp 195 200 205 act tca aaa gaa gtt gaa att atc aac tcc atg ttc ttg ttg act gct 672 Thr Ser Lys Glu Val Glu Ile Ile Asn Ser Met Phe Leu Leu Thr Ala 210 215 220 aag cca tgt atc tat ttg att aat tta tct gaa aga gat tac atc aga 720 Lys Pro Cys Ile Tyr Leu Ile Asn Leu Ser Glu Arg Asp Tyr Ile Arg 225 230 235 240 aag aaa aac aag cat ctg cta aga atc aag gaa tgg gta gac aag tac 768 Lys Lys Asn Lys His Leu Leu Arg Ile Lys Glu Trp Val Asp Lys Tyr 245 250 255 tct cca ggt gac ttg atc att cca ttc agt gtt tct cta gaa gaa aga 816 Ser Pro Gly Asp Leu Ile Ile Pro Phe Ser Val Ser Leu Glu Glu Arg 260 265 270 cta tct cat atg tcc cca gaa gat gct gaa gaa gaa ttg aag aaa ctg 864 Leu Ser His Met Ser Pro Glu Asp Ala Glu Glu Glu Leu Lys Lys Leu 275 280 285 cag aca ata tct gcc ttg cca aag att atc act acc atg aga caa aag 912 Gln Thr Ile Ser Ala Leu Pro Lys Ile Ile Thr Thr Met Arg Gln Lys 290 295 300 tta gat ttg att tcc ttt ttc acc tgc ggt cca gat gaa gtt cgt gaa 960 Leu Asp Leu Ile Ser Phe Phe Thr Cys Gly Pro Asp Glu Val Arg Glu 305 310 315 320 tgg acc atc aga aga ggt act aaa gct cca caa gct gct ggt gtt att 1008 Trp Thr Ile Arg Arg Gly Thr Lys Ala Pro Gln Ala Ala Gly Val Ile 325 330 335 cat aac gat tta atg aat acc ttt att ttg gct caa gtt atg aaa tgt 1056 His Asn Asp Leu Met Asn Thr Phe Ile Leu Ala Gln Val Met Lys Cys 340 345 350 gaa gat gtc ttc gaa tat aag gac gat tct gcc atc aag gcc gct ggt 1104 Glu Asp Val Phe Glu Tyr Lys Asp Asp Ser Ala Ile Lys Ala Ala Gly 355 360 365 aag ttg atg caa aag ggt aaa gac tat gtc gtt gaa gac ggt gat atc 1152 Lys Leu Met Gln Lys Gly Lys Asp Tyr Val Val Glu Asp Gly Asp Ile 370 375 380 att tac ttc aga gct ggt gct ggt aag aat tga 1185 Ile Tyr Phe Arg Ala Gly Ala Gly Lys Asn 385 390 <210> 33 <211> 394 <212> PRT <213> Saccharomyces cerevisiae Page 52 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 33 Met Pro Pro Lys Lys Gln Val Glu Glu Lys Lys Val Leu Leu Gly Arg 1 5 10 15 Pro Gly Asn Asn Leu Lys Ala Gly Ile Val Gly Leu Ala Asn Val Gly 20 25 30 Lys Ser Thr Phe Phe Gln Ala Ile Thr Arg Cys Pro Leu Gly Asn Pro 35 40 45 Ala Asn Tyr Pro Phe Ala Thr Ile Asp Pro Glu Glu Ala Arg Val Ile 50 55 60 Val Pro Ser Pro Arg Phe Asp Lys Leu Cys Glu Ile Tyr Lys Lys Thr 65 70 75 80 Ala Ser Glu Val Pro Ala His Leu Thr Val Tyr Asp Ile Ala Gly Leu 85 90 95 Thr Lys Gly Ala Ser Ala Gly Glu Gly Leu Gly Asn Ala Phe Leu Ser 100 105 110 His Ile Arg Ser Val Asp Ser Ile Tyr Gln Val Val Arg Cys Phe Asp 115 120 125 Asp Ala Glu Ile Ile His Val Glu Gly Asp Val Asp Pro Val Arg Asp 130 135 140 Leu Glu Ile Ile Asn Gln Glu Leu Arg Leu Lys Asp Ile Glu Phe Ala 145 150 155 160 Gln Lys Ala Leu Glu Gly Ala Glu Lys Ile Ala Lys Arg Gly Gly Gln 165 170 175 Ser Leu Glu Val Lys Gln Lys Lys Glu Glu Met Asp Leu Ile Thr Lys 180 185 190 Ile Ile Lys Leu Leu Glu Ser Gly Gln Arg Val Ala Asn His Ser Trp 195 200 205 Thr Ser Lys Glu Val Glu Ile Ile Asn Ser Met Phe Leu Leu Thr Ala 210 215 220 Lys Pro Cys Ile Tyr Leu Ile Asn Leu Ser Glu Arg Asp Tyr Ile Arg 225 230 235 240 Lys Lys Asn Lys His Leu Leu Arg Ile Lys Glu Trp Val Asp Lys Tyr 245 250 255 Page 53 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Pro Gly Asp Leu Ile Ile Pro Phe Ser Val Ser Leu Glu Glu Arg 260 265 270 Leu Ser His Met Ser Pro Glu Asp Ala Glu Glu Glu Leu Lys Lys Leu 275 280 285 Gln Thr Ile Ser Ala Leu Pro Lys Ile Ile Thr Thr Met Arg Gln Lys 290 295 300 Leu Asp Leu Ile Ser Phe Phe Thr Cys Gly Pro Asp Glu Val Arg Glu 305 310 315 320 Trp Thr Ile Arg Arg Gly Thr Lys Ala Pro Gln Ala Ala Gly Val Ile 325 330 335 His Asn Asp Leu Met Asn Thr Phe Ile Leu Ala Gln Val Met Lys Cys 340 345 350 Glu Asp Val Phe Glu Tyr Lys Asp Asp Ser Ala Ile Lys Ala Ala Gly 355 360 365 Lys Leu Met Gln Lys Gly Lys Asp Tyr Val Val Glu Asp Gly Asp Ile 370 375 380 Ile Tyr Phe Arg Ala Gly Ala Gly Lys Asn 385 390 <210> 34 <211> 735 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(735) <400> 34 atg act gtg gtt gaa ata aaa agc cag gac caa ttt acg caa cta acc 48 Met Thr Val Val Glu Ile Lys Ser Gln Asp Gln Phe Thr Gln Leu Thr 1 5 10 15 act aca aac gct gct aat aaa ctc att gtc tta tat ttt aaa gct caa 96 Thr Thr Asn Ala Ala Asn Lys Leu Ile Val Leu Tyr Phe Lys Ala Gln 20 25 30 tgg gct gat cct tgc aaa act atg agc cag gtg cta gaa gct gtt agt 144 Trp Ala Asp Pro Cys Lys Thr Met Ser Gln Val Leu Glu Ala Val Ser 35 40 45 gaa aaa gtt agg caa gag gat gtc cgg ttt tta tca ata gat gca gac 192 Glu Lys Val Arg Gln Glu Asp Val Arg Phe Leu Ser Ile Asp Ala Asp 50 55 60 gaa cat cca gaa ata tca gac ctt ttt gag att gca gcc gta cca tac 240 Glu His Pro Glu Ile Ser Asp Leu Phe Glu Ile Ala Ala Val Pro Tyr 65 70 75 80 ttc gtc ttc att caa aat ggt act att gta aaa gaa ata tca gcc gca 288 Page 54 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Val Phe Ile Gln Asn Gly Thr Ile Val Lys Glu Ile Ser Ala Ala 85 90 95 gat cct aag gag ttt gtg aaa agc tta gaa att ctt tcg aat gct tct 336 Asp Pro Lys Glu Phe Val Lys Ser Leu Glu Ile Leu Ser Asn Ala Ser 100 105 110 gcc tca cta gcg aac aat gcc aag ggt cct aaa tct acg tct gat gag 384 Ala Ser Leu Ala Asn Asn Ala Lys Gly Pro Lys Ser Thr Ser Asp Glu 115 120 125 gaa agc agc ggg tct tcc gat gat gaa gag gac gaa act gaa gaa gaa 432 Glu Ser Ser Gly Ser Ser Asp Asp Glu Glu Asp Glu Thr Glu Glu Glu 130 135 140 ata aat gct agg ctg gtg aag cta gta caa gct gca cct gtg atg cta 480 Ile Asn Ala Arg Leu Val Lys Leu Val Gln Ala Ala Pro Val Met Leu 145 150 155 160 ttc atg aaa gga agc cca tca gaa cct aaa tgc gga ttt tct aga cag 528 Phe Met Lys Gly Ser Pro Ser Glu Pro Lys Cys Gly Phe Ser Arg Gln 165 170 175 tta gtt ggt atc ctc aga gaa cac caa ata agg ttc gga ttt ttt gat 576 Leu Val Gly Ile Leu Arg Glu His Gln Ile Arg Phe Gly Phe Phe Asp 180 185 190 ata tta aga gac gaa aac gtt aga caa agc ttg aag aag ttt tct gat 624 Ile Leu Arg Asp Glu Asn Val Arg Gln Ser Leu Lys Lys Phe Ser Asp 195 200 205 tgg cct act ttt cct cag tta tat atc aat ggg gag ttc cag gga ggt 672 Trp Pro Thr Phe Pro Gln Leu Tyr Ile Asn Gly Glu Phe Gln Gly Gly 210 215 220 ttg gat att atc aag gaa tct ata gaa gaa gat cct gaa tat ttc caa 720 Leu Asp Ile Ile Lys Glu Ser Ile Glu Glu Asp Pro Glu Tyr Phe Gln 225 230 235 240 cat gct cta cag taa 735 His Ala Leu Gln <210> 35 <211> 244 <212> PRT <213> Saccharomyces cerevisiae <400> 35 Met Thr Val Val Glu Ile Lys Ser Gln Asp Gln Phe Thr Gln Leu Thr 1 5 10 15 Thr Thr Asn Ala Ala Asn Lys Leu Ile Val Leu Tyr Phe Lys Ala Gln 20 25 30 Trp Ala Asp Pro Cys Lys Thr Met Ser Gln Val Leu Glu Ala Val Ser 35 40 45 Glu Lys Val Arg Gln Glu Asp Val Arg Phe Leu Ser Ile Asp Ala Asp 50 55 60 Page 55 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu His Pro Glu Ile Ser Asp Leu Phe Glu Ile Ala Ala Val Pro Tyr 65 70 75 80 Phe Val Phe Ile Gln Asn Gly Thr Ile Val Lys Glu Ile Ser Ala Ala 85 90 95 Asp Pro Lys Glu Phe Val Lys Ser Leu Glu Ile Leu Ser Asn Ala Ser 100 105 110 Ala Ser Leu Ala Asn Asn Ala Lys Gly Pro Lys Ser Thr Ser Asp Glu 115 120 125 Glu Ser Ser Gly Ser Ser Asp Asp Glu Glu Asp Glu Thr Glu Glu Glu 130 135 140 Ile Asn Ala Arg Leu Val Lys Leu Val Gln Ala Ala Pro Val Met Leu 145 150 155 160 Phe Met Lys Gly Ser Pro Ser Glu Pro Lys Cys Gly Phe Ser Arg Gln 165 170 175 Leu Val Gly Ile Leu Arg Glu His Gln Ile Arg Phe Gly Phe Phe Asp 180 185 190 Ile Leu Arg Asp Glu Asn Val Arg Gln Ser Leu Lys Lys Phe Ser Asp 195 200 205 Trp Pro Thr Phe Pro Gln Leu Tyr Ile Asn Gly Glu Phe Gln Gly Gly 210 215 220 Leu Asp Ile Ile Lys Glu Ser Ile Glu Glu Asp Pro Glu Tyr Phe Gln 225 230 235 240 His Ala Leu Gln <210> 36 <211> 351 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(351) <400> 36 atg cac att ctt ttc ttg ttt att ttc cac tgt ttg gca ttc aaa gac 48 Met His Ile Leu Phe Leu Phe Ile Phe His Cys Leu Ala Phe Lys Asp 1 5 10 15 ttg att ttt ttt aag caa tac gta cca ttt gca gcg gcg gga gga tat 96 Leu Ile Phe Phe Lys Gln Tyr Val Pro Phe Ala Ala Ala Gly Gly Tyr 20 25 30 ccc ata tcg ttt cta ttc atc aaa gtt ctg acc gcc tca acg aat tta 144 Page 56 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Ile Ser Phe Leu Phe Ile Lys Val Leu Thr Ala Ser Thr Asn Leu 35 40 45 cta ctt tct tct tcc tct gga ggg tcc tgg aat aag tta tcc aaa gag 192 Leu Leu Ser Ser Ser Ser Gly Gly Ser Trp Asn Lys Leu Ser Lys Glu 50 55 60 tcg caa tta ctc aaa gtc att ctc aca cac ttt ctt gtt cct att ttt 240 Ser Gln Leu Leu Lys Val Ile Leu Thr His Phe Leu Val Pro Ile Phe 65 70 75 80 ttt ttc tta ttc caa tat att att tta tca gaa gac aga cag caa gaa 288 Phe Phe Leu Phe Gln Tyr Ile Ile Leu Ser Glu Asp Arg Gln Gln Glu 85 90 95 cga cag cct aag ttt cga gac aac gct aaa ttt gac gga cat gcg aag 336 Arg Gln Pro Lys Phe Arg Asp Asn Ala Lys Phe Asp Gly His Ala Lys 100 105 110 aca tgc cat ata taa 351 Thr Cys His Ile 115 <210> 37 <211> 116 <212> PRT <213> Saccharomyces cerevisiae <400> 37 Met His Ile Leu Phe Leu Phe Ile Phe His Cys Leu Ala Phe Lys Asp 1 5 10 15 Leu Ile Phe Phe Lys Gln Tyr Val Pro Phe Ala Ala Ala Gly Gly Tyr 20 25 30 Pro Ile Ser Phe Leu Phe Ile Lys Val Leu Thr Ala Ser Thr Asn Leu 35 40 45 Leu Leu Ser Ser Ser Ser Gly Gly Ser Trp Asn Lys Leu Ser Lys Glu 50 55 60 Ser Gln Leu Leu Lys Val Ile Leu Thr His Phe Leu Val Pro Ile Phe 65 70 75 80 Phe Phe Leu Phe Gln Tyr Ile Ile Leu Ser Glu Asp Arg Gln Gln Glu 85 90 95 Arg Gln Pro Lys Phe Arg Asp Asn Ala Lys Phe Asp Gly His Ala Lys 100 105 110 Thr Cys His Ile 115 <210> 38 <211> 900 <212> DNA <213> Saccharomyces cerevisiae Page 57 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(900) <400> 38 atg tct acc ttt tct gct tct gat ttc aac tca gaa aga tat tca tct 48 Met Ser Thr Phe Ser Ala Ser Asp Phe Asn Ser Glu Arg Tyr Ser Ser 1 5 10 15 tca aga cct tct tat ccc tcc gat ttt tac aag atg att gat gaa tac 96 Ser Arg Pro Ser Tyr Pro Ser Asp Phe Tyr Lys Met Ile Asp Glu Tyr 20 25 30 cac gac gga gaa agg aaa tta ctc gta gat gtt ggc tgt gga cca ggt 144 His Asp Gly Glu Arg Lys Leu Leu Val Asp Val Gly Cys Gly Pro Gly 35 40 45 act gcc act tta caa atg gct cag gag tta aaa cca ttc gaa caa att 192 Thr Ala Thr Leu Gln Met Ala Gln Glu Leu Lys Pro Phe Glu Gln Ile 50 55 60 atc gga agc gat ctc tcc gct acc atg att aag act gca gaa gta ata 240 Ile Gly Ser Asp Leu Ser Ala Thr Met Ile Lys Thr Ala Glu Val Ile 65 70 75 80 aag gaa gga agt cct gat aca tac aaa aac gtt tca ttt aag att tct 288 Lys Glu Gly Ser Pro Asp Thr Tyr Lys Asn Val Ser Phe Lys Ile Ser 85 90 95 tca agt gat gat ttt aaa ttc cta ggc gcg gat tca gta gac aaa cag 336 Ser Ser Asp Asp Phe Lys Phe Leu Gly Ala Asp Ser Val Asp Lys Gln 100 105 110 aaa att gat atg att acc gca gta gaa tgt gct cat tgg ttc gat ttc 384 Lys Ile Asp Met Ile Thr Ala Val Glu Cys Ala His Trp Phe Asp Phe 115 120 125 gaa aaa ttt cag cga tct gct tat gcc aat ttg aga aaa gat ggt act 432 Glu Lys Phe Gln Arg Ser Ala Tyr Ala Asn Leu Arg Lys Asp Gly Thr 130 135 140 atc gct att tgg ggt tat gcg gac cca att ttc ccg gac tac cct gaa 480 Ile Ala Ile Trp Gly Tyr Ala Asp Pro Ile Phe Pro Asp Tyr Pro Glu 145 150 155 160 ttt gat gat ctg atg att gaa gtt cct tac ggg aag caa gga ctg gga 528 Phe Asp Asp Leu Met Ile Glu Val Pro Tyr Gly Lys Gln Gly Leu Gly 165 170 175 ccc tat tgg gaa caa ccg ggg aga tct cgc ctt cgt aat atg ctg aaa 576 Pro Tyr Trp Glu Gln Pro Gly Arg Ser Arg Leu Arg Asn Met Leu Lys 180 185 190 gac tct cac tta gac cca gaa ctt ttc cat gat ata caa gtt tca tat 624 Asp Ser His Leu Asp Pro Glu Leu Phe His Asp Ile Gln Val Ser Tyr 195 200 205 ttt tgt gca gaa gat gtg aga gac aaa gta aaa ctc cac cag cat aca 672 Phe Cys Ala Glu Asp Val Arg Asp Lys Val Lys Leu His Gln His Thr 210 215 220 aag aag cca ttg cta atc aga aag cag gtc acc cta gtg gag ttt gca 720 Lys Lys Pro Leu Leu Ile Arg Lys Gln Val Thr Leu Val Glu Phe Ala 225 230 235 240 gat tat gtc aga acc tgg agc gct tac cat cag tgg aag cag gat cca 768 Page 58 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Tyr Val Arg Thr Trp Ser Ala Tyr His Gln Trp Lys Gln Asp Pro 245 250 255 aag aac aaa gat aaa gaa gat gta gca gat tgg ttt att aaa gag tca 816 Lys Asn Lys Asp Lys Glu Asp Val Ala Asp Trp Phe Ile Lys Glu Ser 260 265 270 cta agg agg agg ccg gaa ctt tcc acc aac acc aaa att gaa gtt gtt 864 Leu Arg Arg Arg Pro Glu Leu Ser Thr Asn Thr Lys Ile Glu Val Val 275 280 285 tgg aat act ttt tac aaa ctt ggc aaa agg gtc tga 900 Trp Asn Thr Phe Tyr Lys Leu Gly Lys Arg Val 290 295 <210> 39 <211> 299 <212> PRT <213> Saccharomyces cerevisiae <400> 39 Met Ser Thr Phe Ser Ala Ser Asp Phe Asn Ser Glu Arg Tyr Ser Ser 1 5 10 15 Ser Arg Pro Ser Tyr Pro Ser Asp Phe Tyr Lys Met Ile Asp Glu Tyr 20 25 30 His Asp Gly Glu Arg Lys Leu Leu Val Asp Val Gly Cys Gly Pro Gly 35 40 45 Thr Ala Thr Leu Gln Met Ala Gln Glu Leu Lys Pro Phe Glu Gln Ile 50 55 60 Ile Gly Ser Asp Leu Ser Ala Thr Met Ile Lys Thr Ala Glu Val Ile 65 70 75 80 Lys Glu Gly Ser Pro Asp Thr Tyr Lys Asn Val Ser Phe Lys Ile Ser 85 90 95 Ser Ser Asp Asp Phe Lys Phe Leu Gly Ala Asp Ser Val Asp Lys Gln 100 105 110 Lys Ile Asp Met Ile Thr Ala Val Glu Cys Ala His Trp Phe Asp Phe 115 120 125 Glu Lys Phe Gln Arg Ser Ala Tyr Ala Asn Leu Arg Lys Asp Gly Thr 130 135 140 Ile Ala Ile Trp Gly Tyr Ala Asp Pro Ile Phe Pro Asp Tyr Pro Glu 145 150 155 160 Phe Asp Asp Leu Met Ile Glu Val Pro Tyr Gly Lys Gln Gly Leu Gly 165 170 175 Pro Tyr Trp Glu Gln Pro Gly Arg Ser Arg Leu Arg Asn Met Leu Lys Page 59 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 180 185 190 Asp Ser His Leu Asp Pro Glu Leu Phe His Asp Ile Gln Val Ser Tyr 195 200 205 Phe Cys Ala Glu Asp Val Arg Asp Lys Val Lys Leu His Gln His Thr 210 215 220 Lys Lys Pro Leu Leu Ile Arg Lys Gln Val Thr Leu Val Glu Phe Ala 225 230 235 240 Asp Tyr Val Arg Thr Trp Ser Ala Tyr His Gln Trp Lys Gln Asp Pro 245 250 255 Lys Asn Lys Asp Lys Glu Asp Val Ala Asp Trp Phe Ile Lys Glu Ser 260 265 270 Leu Arg Arg Arg Pro Glu Leu Ser Thr Asn Thr Lys Ile Glu Val Val 275 280 285 Trp Asn Thr Phe Tyr Lys Leu Gly Lys Arg Val 290 295 <210> 40 <211> 336 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(336) <400> 40 atg aaa ggt tca aaa tcg cac ctt gtc ttc act ctc ctg caa gta tca 48 Met Lys Gly Ser Lys Ser His Leu Val Phe Thr Leu Leu Gln Val Ser 1 5 10 15 caa cta aat gtt ttt ctt ttc ttt cta ggt ttt ttg ttg cca tta ttc 96 Gln Leu Asn Val Phe Leu Phe Phe Leu Gly Phe Leu Leu Pro Leu Phe 20 25 30 tta gga ctg ttc gtt tca ctg cgc tct ttg gct ctt gca cta tcc tct 144 Leu Gly Leu Phe Val Ser Leu Arg Ser Leu Ala Leu Ala Leu Ser Ser 35 40 45 ggg tgg ttt att atg gat ctg ata cta ttt cgc acc ttt cca gaa gca 192 Gly Trp Phe Ile Met Asp Leu Ile Leu Phe Arg Thr Phe Pro Glu Ala 50 55 60 gaa tta tat cca gca gtc atc ggt aaa cca tct ggt ctg ggg ctt act 240 Glu Leu Tyr Pro Ala Val Ile Gly Lys Pro Ser Gly Leu Gly Leu Thr 65 70 75 80 gag gca ttt gag ttt ata tcc att ttt ttc cct gat gtt cag caa acc 288 Glu Ala Phe Glu Phe Ile Ser Ile Phe Phe Pro Asp Val Gln Gln Thr 85 90 95 gaa aga aat ata aaa tac aac tgg gaa aga tgt ttt aat ggt gag taa 336 Glu Arg Asn Ile Lys Tyr Asn Trp Glu Arg Cys Phe Asn Gly Glu Page 60 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 100 105 110 <210> 41 <211> 111 <212> PRT <213> Saccharomyces cerevisiae <400> 41 Met Lys Gly Ser Lys Ser His Leu Val Phe Thr Leu Leu Gln Val Ser 1 5 10 15 Gln Leu Asn Val Phe Leu Phe Phe Leu Gly Phe Leu Leu Pro Leu Phe 20 25 30 Leu Gly Leu Phe Val Ser Leu Arg Ser Leu Ala Leu Ala Leu Ser Ser 35 40 45 Gly Trp Phe Ile Met Asp Leu Ile Leu Phe Arg Thr Phe Pro Glu Ala 50 55 60 Glu Leu Tyr Pro Ala Val Ile Gly Lys Pro Ser Gly Leu Gly Leu Thr 65 70 75 80 Glu Ala Phe Glu Phe Ile Ser Ile Phe Phe Pro Asp Val Gln Gln Thr 85 90 95 Glu Arg Asn Ile Lys Tyr Asn Trp Glu Arg Cys Phe Asn Gly Glu 100 105 110 <210> 42 <211> 2556 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2556) <400> 42 atg ccg aag aat agt cac cac cat cgt tcc agt tcg gtt aat tcc aca 48 Met Pro Lys Asn Ser His His His Arg Ser Ser Ser Val Asn Ser Thr 1 5 10 15 aag agt cgt tct acg gaa tct acg aat aaa tgg aaa att ccg cac tat 96 Lys Ser Arg Ser Thr Glu Ser Thr Asn Lys Trp Lys Ile Pro His Tyr 20 25 30 tat cgc aga tcc gct agc ggc agc aca caa gct tcg ccg gac agg aac 144 Tyr Arg Arg Ser Ala Ser Gly Ser Thr Gln Ala Ser Pro Asp Arg Asn 35 40 45 tcc tca aca ggc tca tgt agc act cca gta tta cct act atg aat gtt 192 Ser Ser Thr Gly Ser Cys Ser Thr Pro Val Leu Pro Thr Met Asn Val 50 55 60 atg tct agc ccg aaa aaa gtt ttg cta gag gat ccc aga gac aac cat 240 Met Ser Ser Pro Lys Lys Val Leu Leu Glu Asp Pro Arg Asp Asn His 65 70 75 80 Page 61 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt act aag gcg aag aag agt agt aga aag aaa tca ggt gaa atg gtc ttc 288 Thr Lys Ala Lys Lys Ser Ser Arg Lys Lys Ser Gly Glu Met Val Phe 85 90 95 gtc aat tat act gta cag gac acg gct aac gaa aat gat act gac ttg 336 Val Asn Tyr Thr Val Gln Asp Thr Ala Asn Glu Asn Asp Thr Asp Leu 100 105 110 caa acc cag ccg gtt tct gtg cca gca cca aag gcg aaa tta aag aag 384 Gln Thr Gln Pro Val Ser Val Pro Ala Pro Lys Ala Lys Leu Lys Lys 115 120 125 aaa tcc tcc aaa agg aga atg ctg aag ata ttt gga tcg tca aag aac 432 Lys Ser Ser Lys Arg Arg Met Leu Lys Ile Phe Gly Ser Ser Lys Asn 130 135 140 gaa cac ata gag gac atc gtt gaa gag caa cca atg gtg ctt caa atg 480 Glu His Ile Glu Asp Ile Val Glu Glu Gln Pro Met Val Leu Gln Met 145 150 155 160 gat tca gaa tct aaa ccc ctt tcg gga acc cct atc tca gaa agc gga 528 Asp Ser Glu Ser Lys Pro Leu Ser Gly Thr Pro Ile Ser Glu Ser Gly 165 170 175 atc gac gcc tcg tca cta aca acc aaa aga tct tat aac tcg ttc tta 576 Ile Asp Ala Ser Ser Leu Thr Thr Lys Arg Ser Tyr Asn Ser Phe Leu 180 185 190 aaa cac aat agg cta aac ggt aaa act ccg ttc tct gga aac ttg tcc 624 Lys His Asn Arg Leu Asn Gly Lys Thr Pro Phe Ser Gly Asn Leu Ser 195 200 205 ttt cca tca tta aac atg atg ggt aac act act gat ctg cct att gac 672 Phe Pro Ser Leu Asn Met Met Gly Asn Thr Thr Asp Leu Pro Ile Asp 210 215 220 aat aac gat ttt tgt tcc gag aaa gaa gtc gtt ccg aaa tca act cat 720 Asn Asn Asp Phe Cys Ser Glu Lys Glu Val Val Pro Lys Ser Thr His 225 230 235 240 gat cct tca cta gca aaa ccg cca tca agg ttc act gaa agc gaa aca 768 Asp Pro Ser Leu Ala Lys Pro Pro Ser Arg Phe Thr Glu Ser Glu Thr 245 250 255 aat tct act ccc aac tta tca agt ata cct ctc atg aac aca aaa aat 816 Asn Ser Thr Pro Asn Leu Ser Ser Ile Pro Leu Met Asn Thr Lys Asn 260 265 270 aca aga ttg aag tac aat aaa gtg gcg cct cag agt tca gac cga caa 864 Thr Arg Leu Lys Tyr Asn Lys Val Ala Pro Gln Ser Ser Asp Arg Gln 275 280 285 aag tca cag gaa agt ggg cta tat cat tct acc gaa tca ttc aac ttc 912 Lys Ser Gln Glu Ser Gly Leu Tyr His Ser Thr Glu Ser Phe Asn Phe 290 295 300 aaa gat caa aac tac agt aac aat aaa tcc tct tta agt ctg aac tcc 960 Lys Asp Gln Asn Tyr Ser Asn Asn Lys Ser Ser Leu Ser Leu Asn Ser 305 310 315 320 gat tta agt aca ccc cac ttt gca aag cat tca cct gat tca cca aga 1008 Asp Leu Ser Thr Pro His Phe Ala Lys His Ser Pro Asp Ser Pro Arg 325 330 335 act tca aga tct ttc aac tgc gga gac tca caa agt aaa gtt aaa tta 1056 Thr Ser Arg Ser Phe Asn Cys Gly Asp Ser Gln Ser Lys Val Lys Leu 340 345 350 Page 62 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ccg gaa gaa aat gac gct tct att gca ttt agt aag atg ttt act aga 1104 Pro Glu Glu Asn Asp Ala Ser Ile Ala Phe Ser Lys Met Phe Thr Arg 355 360 365 aaa cga gcc aac act ggc ggg tcc acg tgt tcg cta gcc tca ccc act 1152 Lys Arg Ala Asn Thr Gly Gly Ser Thr Cys Ser Leu Ala Ser Pro Thr 370 375 380 att gca caa act att cag caa tca aat ata aaa gtt aat aaa ttg cca 1200 Ile Ala Gln Thr Ile Gln Gln Ser Asn Ile Lys Val Asn Lys Leu Pro 385 390 395 400 act cag cga acc act tca gtt ggc tca tta tca tcc atg tca aat cgt 1248 Thr Gln Arg Thr Thr Ser Val Gly Ser Leu Ser Ser Met Ser Asn Arg 405 410 415 tat tca cca ata aga gtt gca tcg cca gga aga gca aga tcc gca act 1296 Tyr Ser Pro Ile Arg Val Ala Ser Pro Gly Arg Ala Arg Ser Ala Thr 420 425 430 cgt ggg tct tcc ctt tat aga tta tcc aga gac ctt aat tct tta cca 1344 Arg Gly Ser Ser Leu Tyr Arg Leu Ser Arg Asp Leu Asn Ser Leu Pro 435 440 445 agc gtc act gat cta cca gaa atg gat agt aca acc cca gtt aac gaa 1392 Ser Val Thr Asp Leu Pro Glu Met Asp Ser Thr Thr Pro Val Asn Glu 450 455 460 ata ttc ttg gat ggc caa cca cag cat aaa agt ggc agt gtc aaa gga 1440 Ile Phe Leu Asp Gly Gln Pro Gln His Lys Ser Gly Ser Val Lys Gly 465 470 475 480 ggg cat agg aag aaa caa gaa tct atc tct gat gct caa aga att caa 1488 Gly His Arg Lys Lys Gln Glu Ser Ile Ser Asp Ala Gln Arg Ile Gln 485 490 495 cat tct aat tcg tac att aca aca cct tca tct tct ctg gtg act cct 1536 His Ser Asn Ser Tyr Ile Thr Thr Pro Ser Ser Ser Leu Val Thr Pro 500 505 510 cct tac tac atg aca ggt tac aca tta cca agt tct gca tct gct tct 1584 Pro Tyr Tyr Met Thr Gly Tyr Thr Leu Pro Ser Ser Ala Ser Ala Ser 515 520 525 tca act cca aat gtg ctt gaa aca cac aat atg aac ttt gtt cca agt 1632 Ser Thr Pro Asn Val Leu Glu Thr His Asn Met Asn Phe Val Pro Ser 530 535 540 acc agt act gtt aca agt tat cgc cca tct agc aat ttt tcc tca ttt 1680 Thr Ser Thr Val Thr Ser Tyr Arg Pro Ser Ser Asn Phe Ser Ser Phe 545 550 555 560 gac aaa gaa tac agt aac gaa aac gac gct agt ggg gaa ttc tct gct 1728 Asp Lys Glu Tyr Ser Asn Glu Asn Asp Ala Ser Gly Glu Phe Ser Ala 565 570 575 ttc aat act cca atg gag aat ata ccg gca cta aaa ggt ata cct aga 1776 Phe Asn Thr Pro Met Glu Asn Ile Pro Ala Leu Lys Gly Ile Pro Arg 580 585 590 tcc acg tta gaa gaa aat gaa gaa gag gat gtc cta gta caa gat att 1824 Ser Thr Leu Glu Glu Asn Glu Glu Glu Asp Val Leu Val Gln Asp Ile 595 600 605 ccg aat acg gca cac ttc caa aga agg gat att atg ggg atg gat act 1872 Pro Asn Thr Ala His Phe Gln Arg Arg Asp Ile Met Gly Met Asp Thr 610 615 620 Page 63 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cac aga aag gat gac agt tta gat ttt aac tct ttg atg cca cac ggt 1920 His Arg Lys Asp Asp Ser Leu Asp Phe Asn Ser Leu Met Pro His Gly 625 630 635 640 agt aca act agt agc agc atc gta gat tct gtt atg acg aac tca ata 1968 Ser Thr Thr Ser Ser Ser Ile Val Asp Ser Val Met Thr Asn Ser Ile 645 650 655 tcc act aca aca agc aac gcg acc gga aac tac ttt caa gat caa gat 2016 Ser Thr Thr Thr Ser Asn Ala Thr Gly Asn Tyr Phe Gln Asp Gln Asp 660 665 670 aag tat aca ttg gta aat acg gga ttg gga ttg agt gat gca aac ctc 2064 Lys Tyr Thr Leu Val Asn Thr Gly Leu Gly Leu Ser Asp Ala Asn Leu 675 680 685 gat cat ttt att aga tct caa tgg aaa cac gct tct cga tca gaa tcc 2112 Asp His Phe Ile Arg Ser Gln Trp Lys His Ala Ser Arg Ser Glu Ser 690 695 700 aat aat aat acc gga aat cgc gtt tct tac agt ggc tca aca cca aac 2160 Asn Asn Asn Thr Gly Asn Arg Val Ser Tyr Ser Gly Ser Thr Pro Asn 705 710 715 720 aat gtt gat aca aca aag act aat ttg caa gtg tat acc gag ttc gat 2208 Asn Val Asp Thr Thr Lys Thr Asn Leu Gln Val Tyr Thr Glu Phe Asp 725 730 735 ttt gaa aac cca gag tcg ttt ttc cat gag caa tcg aag cta cta ggt 2256 Phe Glu Asn Pro Glu Ser Phe Phe His Glu Gln Ser Lys Leu Leu Gly 740 745 750 gag atg ggc cac agc aat aac aac agc aac agc gcc atc aac atg aat 2304 Glu Met Gly His Ser Asn Asn Asn Ser Asn Ser Ala Ile Asn Met Asn 755 760 765 gaa ccc aag tct gcg gat aca tac att gga aat ata tct ccg gat act 2352 Glu Pro Lys Ser Ala Asp Thr Tyr Ile Gly Asn Ile Ser Pro Asp Thr 770 775 780 tca gca act gtt tca tta ggc gac ctg atg ggc tca aac gtt tca aac 2400 Ser Ala Thr Val Ser Leu Gly Asp Leu Met Gly Ser Asn Val Ser Asn 785 790 795 800 aac agt gaa aga aat ttt tac gat ggt cat act ttc gtt cca cag tat 2448 Asn Ser Glu Arg Asn Phe Tyr Asp Gly His Thr Phe Val Pro Gln Tyr 805 810 815 cag gcg aac tca tct gtg gaa aac tca aat aat caa aat gca gca cca 2496 Gln Ala Asn Ser Ser Val Glu Asn Ser Asn Asn Gln Asn Ala Ala Pro 820 825 830 att gca aat aac gac att gat aat aat tta cag tct ttt tat ttt gat 2544 Ile Ala Asn Asn Asp Ile Asp Asn Asn Leu Gln Ser Phe Tyr Phe Asp 835 840 845 aat agc aac taa 2556 Asn Ser Asn 850 <210> 43 <211> 851 <212> PRT <213> Saccharomyces cerevisiae <400> 43 Page 64 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Pro Lys Asn Ser His His His Arg Ser Ser Ser Val Asn Ser Thr 1 5 10 15 Lys Ser Arg Ser Thr Glu Ser Thr Asn Lys Trp Lys Ile Pro His Tyr 20 25 30 Tyr Arg Arg Ser Ala Ser Gly Ser Thr Gln Ala Ser Pro Asp Arg Asn 35 40 45 Ser Ser Thr Gly Ser Cys Ser Thr Pro Val Leu Pro Thr Met Asn Val 50 55 60 Met Ser Ser Pro Lys Lys Val Leu Leu Glu Asp Pro Arg Asp Asn His 65 70 75 80 Thr Lys Ala Lys Lys Ser Ser Arg Lys Lys Ser Gly Glu Met Val Phe 85 90 95 Val Asn Tyr Thr Val Gln Asp Thr Ala Asn Glu Asn Asp Thr Asp Leu 100 105 110 Gln Thr Gln Pro Val Ser Val Pro Ala Pro Lys Ala Lys Leu Lys Lys 115 120 125 Lys Ser Ser Lys Arg Arg Met Leu Lys Ile Phe Gly Ser Ser Lys Asn 130 135 140 Glu His Ile Glu Asp Ile Val Glu Glu Gln Pro Met Val Leu Gln Met 145 150 155 160 Asp Ser Glu Ser Lys Pro Leu Ser Gly Thr Pro Ile Ser Glu Ser Gly 165 170 175 Ile Asp Ala Ser Ser Leu Thr Thr Lys Arg Ser Tyr Asn Ser Phe Leu 180 185 190 Lys His Asn Arg Leu Asn Gly Lys Thr Pro Phe Ser Gly Asn Leu Ser 195 200 205 Phe Pro Ser Leu Asn Met Met Gly Asn Thr Thr Asp Leu Pro Ile Asp 210 215 220 Asn Asn Asp Phe Cys Ser Glu Lys Glu Val Val Pro Lys Ser Thr His 225 230 235 240 Asp Pro Ser Leu Ala Lys Pro Pro Ser Arg Phe Thr Glu Ser Glu Thr 245 250 255 Asn Ser Thr Pro Asn Leu Ser Ser Ile Pro Leu Met Asn Thr Lys Asn 260 265 270 Page 65 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Arg Leu Lys Tyr Asn Lys Val Ala Pro Gln Ser Ser Asp Arg Gln 275 280 285 Lys Ser Gln Glu Ser Gly Leu Tyr His Ser Thr Glu Ser Phe Asn Phe 290 295 300 Lys Asp Gln Asn Tyr Ser Asn Asn Lys Ser Ser Leu Ser Leu Asn Ser 305 310 315 320 Asp Leu Ser Thr Pro His Phe Ala Lys His Ser Pro Asp Ser Pro Arg 325 330 335 Thr Ser Arg Ser Phe Asn Cys Gly Asp Ser Gln Ser Lys Val Lys Leu 340 345 350 Pro Glu Glu Asn Asp Ala Ser Ile Ala Phe Ser Lys Met Phe Thr Arg 355 360 365 Lys Arg Ala Asn Thr Gly Gly Ser Thr Cys Ser Leu Ala Ser Pro Thr 370 375 380 Ile Ala Gln Thr Ile Gln Gln Ser Asn Ile Lys Val Asn Lys Leu Pro 385 390 395 400 Thr Gln Arg Thr Thr Ser Val Gly Ser Leu Ser Ser Met Ser Asn Arg 405 410 415 Tyr Ser Pro Ile Arg Val Ala Ser Pro Gly Arg Ala Arg Ser Ala Thr 420 425 430 Arg Gly Ser Ser Leu Tyr Arg Leu Ser Arg Asp Leu Asn Ser Leu Pro 435 440 445 Ser Val Thr Asp Leu Pro Glu Met Asp Ser Thr Thr Pro Val Asn Glu 450 455 460 Ile Phe Leu Asp Gly Gln Pro Gln His Lys Ser Gly Ser Val Lys Gly 465 470 475 480 Gly His Arg Lys Lys Gln Glu Ser Ile Ser Asp Ala Gln Arg Ile Gln 485 490 495 His Ser Asn Ser Tyr Ile Thr Thr Pro Ser Ser Ser Leu Val Thr Pro 500 505 510 Pro Tyr Tyr Met Thr Gly Tyr Thr Leu Pro Ser Ser Ala Ser Ala Ser 515 520 525 Ser Thr Pro Asn Val Leu Glu Thr His Asn Met Asn Phe Val Pro Ser 530 535 540 Page 66 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Ser Thr Val Thr Ser Tyr Arg Pro Ser Ser Asn Phe Ser Ser Phe 545 550 555 560 Asp Lys Glu Tyr Ser Asn Glu Asn Asp Ala Ser Gly Glu Phe Ser Ala 565 570 575 Phe Asn Thr Pro Met Glu Asn Ile Pro Ala Leu Lys Gly Ile Pro Arg 580 585 590 Ser Thr Leu Glu Glu Asn Glu Glu Glu Asp Val Leu Val Gln Asp Ile 595 600 605 Pro Asn Thr Ala His Phe Gln Arg Arg Asp Ile Met Gly Met Asp Thr 610 615 620 His Arg Lys Asp Asp Ser Leu Asp Phe Asn Ser Leu Met Pro His Gly 625 630 635 640 Ser Thr Thr Ser Ser Ser Ile Val Asp Ser Val Met Thr Asn Ser Ile 645 650 655 Ser Thr Thr Thr Ser Asn Ala Thr Gly Asn Tyr Phe Gln Asp Gln Asp 660 665 670 Lys Tyr Thr Leu Val Asn Thr Gly Leu Gly Leu Ser Asp Ala Asn Leu 675 680 685 Asp His Phe Ile Arg Ser Gln Trp Lys His Ala Ser Arg Ser Glu Ser 690 695 700 Asn Asn Asn Thr Gly Asn Arg Val Ser Tyr Ser Gly Ser Thr Pro Asn 705 710 715 720 Asn Val Asp Thr Thr Lys Thr Asn Leu Gln Val Tyr Thr Glu Phe Asp 725 730 735 Phe Glu Asn Pro Glu Ser Phe Phe His Glu Gln Ser Lys Leu Leu Gly 740 745 750 Glu Met Gly His Ser Asn Asn Asn Ser Asn Ser Ala Ile Asn Met Asn 755 760 765 Glu Pro Lys Ser Ala Asp Thr Tyr Ile Gly Asn Ile Ser Pro Asp Thr 770 775 780 Ser Ala Thr Val Ser Leu Gly Asp Leu Met Gly Ser Asn Val Ser Asn 785 790 795 800 Asn Ser Glu Arg Asn Phe Tyr Asp Gly His Thr Phe Val Pro Gln Tyr Page 67 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 805 810 815 Gln Ala Asn Ser Ser Val Glu Asn Ser Asn Asn Gln Asn Ala Ala Pro 820 825 830 Ile Ala Asn Asn Asp Ile Asp Asn Asn Leu Gln Ser Phe Tyr Phe Asp 835 840 845 Asn Ser Asn 850 <210> 44 <211> 1575 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1575) <400> 44 atg tcc caa cga tct tca caa cac att gta ggt att cat tat gct gta 48 Met Ser Gln Arg Ser Ser Gln His Ile Val Gly Ile His Tyr Ala Val 1 5 10 15 gga cct aag att ggc gaa ggg tct ttc gga gta ata ttt gag gga gag 96 Gly Pro Lys Ile Gly Glu Gly Ser Phe Gly Val Ile Phe Glu Gly Glu 20 25 30 aac att ctt cat tct tgt caa gcg cag acc ggt agc aag agg gac tct 144 Asn Ile Leu His Ser Cys Gln Ala Gln Thr Gly Ser Lys Arg Asp Ser 35 40 45 agt ata ata atg gcg aac gag cca gtc gca att aaa ttc gaa ccg cga 192 Ser Ile Ile Met Ala Asn Glu Pro Val Ala Ile Lys Phe Glu Pro Arg 50 55 60 cat tcg gac gca ccc cag ttg cgt gac gaa ttt aga gcc tat agg ata 240 His Ser Asp Ala Pro Gln Leu Arg Asp Glu Phe Arg Ala Tyr Arg Ile 65 70 75 80 ttg aat ggc tgc gtt gga att ccc cat gct tat tat ttt ggt caa gaa 288 Leu Asn Gly Cys Val Gly Ile Pro His Ala Tyr Tyr Phe Gly Gln Glu 85 90 95 ggt atg cac aac atc ttg att atc gat tta cta ggg cca tca ttg gaa 336 Gly Met His Asn Ile Leu Ile Ile Asp Leu Leu Gly Pro Ser Leu Glu 100 105 110 gat ctc ttt gag tgg tgt ggt aga aaa ttt tca gtg aaa aca acc tgt 384 Asp Leu Phe Glu Trp Cys Gly Arg Lys Phe Ser Val Lys Thr Thr Cys 115 120 125 atg gtt gcc aag caa atg att gat aga gtt aga gca att cat gat cac 432 Met Val Ala Lys Gln Met Ile Asp Arg Val Arg Ala Ile His Asp His 130 135 140 gac tta atc tat cgc gat att aaa ccc gat aac ttt tta att tct caa 480 Asp Leu Ile Tyr Arg Asp Ile Lys Pro Asp Asn Phe Leu Ile Ser Gln 145 150 155 160 tat caa aga att tca cct gaa gga aaa gtc att aaa tca tgt gcc tcc 528 Tyr Gln Arg Ile Ser Pro Glu Gly Lys Val Ile Lys Ser Cys Ala Ser Page 68 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 165 170 175 tct tct aat aat gat ccc aat tta ata tac atg gtt gac ttt ggt atg 576 Ser Ser Asn Asn Asp Pro Asn Leu Ile Tyr Met Val Asp Phe Gly Met 180 185 190 gca aaa caa tat aga gat cca aga acg aaa caa cat ata cca tac cgt 624 Ala Lys Gln Tyr Arg Asp Pro Arg Thr Lys Gln His Ile Pro Tyr Arg 195 200 205 gaa cga aaa tca ttg agc ggt acc gcc aga tat atg tct att aat act 672 Glu Arg Lys Ser Leu Ser Gly Thr Ala Arg Tyr Met Ser Ile Asn Thr 210 215 220 cat ttt gga aga gaa cag tca cgt agg gat gat tta gaa tcg cta ggt 720 His Phe Gly Arg Glu Gln Ser Arg Arg Asp Asp Leu Glu Ser Leu Gly 225 230 235 240 cac gtt ttt ttt tat ttc ttg agg gga tcc ttg cca tgg caa ggt ttg 768 His Val Phe Phe Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu 245 250 255 aaa gca cca aac aac aaa ctg aag tat gaa aag att ggt atg act aaa 816 Lys Ala Pro Asn Asn Lys Leu Lys Tyr Glu Lys Ile Gly Met Thr Lys 260 265 270 cag aaa ttg aat cct gat gat ctt tta ttg aat aat gct att cct tat 864 Gln Lys Leu Asn Pro Asp Asp Leu Leu Leu Asn Asn Ala Ile Pro Tyr 275 280 285 cag ttt gcc aca tat tta aaa tat gca cgt tcc ttg aag ttc gac gaa 912 Gln Phe Ala Thr Tyr Leu Lys Tyr Ala Arg Ser Leu Lys Phe Asp Glu 290 295 300 gat ccg gat tat gac tat tta atc tcg tta atg gat gac gct ttg aga 960 Asp Pro Asp Tyr Asp Tyr Leu Ile Ser Leu Met Asp Asp Ala Leu Arg 305 310 315 320 tta aac gac tta aag gat gat gga cac tat gac tgg atg gat ttg aat 1008 Leu Asn Asp Leu Lys Asp Asp Gly His Tyr Asp Trp Met Asp Leu Asn 325 330 335 ggt ggt aaa ggc tgg aat atc aag att aat aga aga gct aac ttg cat 1056 Gly Gly Lys Gly Trp Asn Ile Lys Ile Asn Arg Arg Ala Asn Leu His 340 345 350 ggt tac gga aat cca aat cca aga gtc aat ggc aat act gca aga aac 1104 Gly Tyr Gly Asn Pro Asn Pro Arg Val Asn Gly Asn Thr Ala Arg Asn 355 360 365 aat gtg aat acg aat tca aag aca cga aat aca acg cca gtt gcg aca 1152 Asn Val Asn Thr Asn Ser Lys Thr Arg Asn Thr Thr Pro Val Ala Thr 370 375 380 cct aag caa caa gct caa aac agt tat aac aag gac aat tcg aaa tcc 1200 Pro Lys Gln Gln Ala Gln Asn Ser Tyr Asn Lys Asp Asn Ser Lys Ser 385 390 395 400 aga att tct tcg aac ccg cag agc ttt act aaa caa caa cac gtc ttg 1248 Arg Ile Ser Ser Asn Pro Gln Ser Phe Thr Lys Gln Gln His Val Leu 405 410 415 aaa aaa atc gaa ccc aat agt aaa tat att cct gaa aca cat tca aat 1296 Lys Lys Ile Glu Pro Asn Ser Lys Tyr Ile Pro Glu Thr His Ser Asn 420 425 430 ctt caa cgg cca att aaa agt caa agt caa acg tac gac tcc atc agt 1344 Leu Gln Arg Pro Ile Lys Ser Gln Ser Gln Thr Tyr Asp Ser Ile Ser Page 69 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 435 440 445 cat aca caa aat tca cca ttt gta cca tat tca agt tct aaa gct aac 1392 His Thr Gln Asn Ser Pro Phe Val Pro Tyr Ser Ser Ser Lys Ala Asn 450 455 460 cct aaa aga agt aat aat gag cac aac tta cca aac cac tac aca aac 1440 Pro Lys Arg Ser Asn Asn Glu His Asn Leu Pro Asn His Tyr Thr Asn 465 470 475 480 ctt gca aat aag aat atc aat tat caa agt caa cga aat tac gaa caa 1488 Leu Ala Asn Lys Asn Ile Asn Tyr Gln Ser Gln Arg Asn Tyr Glu Gln 485 490 495 gaa aat gat gct tat tct gat gac gag aat gat aca ttt tgt tct aaa 1536 Glu Asn Asp Ala Tyr Ser Asp Asp Glu Asn Asp Thr Phe Cys Ser Lys 500 505 510 ata tac aaa tat tgt tgt tgc tgt ttt tgt tgc tgt tga 1575 Ile Tyr Lys Tyr Cys Cys Cys Cys Phe Cys Cys Cys 515 520 <210> 45 <211> 524 <212> PRT <213> Saccharomyces cerevisiae <400> 45 Met Ser Gln Arg Ser Ser Gln His Ile Val Gly Ile His Tyr Ala Val 1 5 10 15 Gly Pro Lys Ile Gly Glu Gly Ser Phe Gly Val Ile Phe Glu Gly Glu 20 25 30 Asn Ile Leu His Ser Cys Gln Ala Gln Thr Gly Ser Lys Arg Asp Ser 35 40 45 Ser Ile Ile Met Ala Asn Glu Pro Val Ala Ile Lys Phe Glu Pro Arg 50 55 60 His Ser Asp Ala Pro Gln Leu Arg Asp Glu Phe Arg Ala Tyr Arg Ile 65 70 75 80 Leu Asn Gly Cys Val Gly Ile Pro His Ala Tyr Tyr Phe Gly Gln Glu 85 90 95 Gly Met His Asn Ile Leu Ile Ile Asp Leu Leu Gly Pro Ser Leu Glu 100 105 110 Asp Leu Phe Glu Trp Cys Gly Arg Lys Phe Ser Val Lys Thr Thr Cys 115 120 125 Met Val Ala Lys Gln Met Ile Asp Arg Val Arg Ala Ile His Asp His 130 135 140 Page 70 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Leu Ile Tyr Arg Asp Ile Lys Pro Asp Asn Phe Leu Ile Ser Gln 145 150 155 160 Tyr Gln Arg Ile Ser Pro Glu Gly Lys Val Ile Lys Ser Cys Ala Ser 165 170 175 Ser Ser Asn Asn Asp Pro Asn Leu Ile Tyr Met Val Asp Phe Gly Met 180 185 190 Ala Lys Gln Tyr Arg Asp Pro Arg Thr Lys Gln His Ile Pro Tyr Arg 195 200 205 Glu Arg Lys Ser Leu Ser Gly Thr Ala Arg Tyr Met Ser Ile Asn Thr 210 215 220 His Phe Gly Arg Glu Gln Ser Arg Arg Asp Asp Leu Glu Ser Leu Gly 225 230 235 240 His Val Phe Phe Tyr Phe Leu Arg Gly Ser Leu Pro Trp Gln Gly Leu 245 250 255 Lys Ala Pro Asn Asn Lys Leu Lys Tyr Glu Lys Ile Gly Met Thr Lys 260 265 270 Gln Lys Leu Asn Pro Asp Asp Leu Leu Leu Asn Asn Ala Ile Pro Tyr 275 280 285 Gln Phe Ala Thr Tyr Leu Lys Tyr Ala Arg Ser Leu Lys Phe Asp Glu 290 295 300 Asp Pro Asp Tyr Asp Tyr Leu Ile Ser Leu Met Asp Asp Ala Leu Arg 305 310 315 320 Leu Asn Asp Leu Lys Asp Asp Gly His Tyr Asp Trp Met Asp Leu Asn 325 330 335 Gly Gly Lys Gly Trp Asn Ile Lys Ile Asn Arg Arg Ala Asn Leu His 340 345 350 Gly Tyr Gly Asn Pro Asn Pro Arg Val Asn Gly Asn Thr Ala Arg Asn 355 360 365 Asn Val Asn Thr Asn Ser Lys Thr Arg Asn Thr Thr Pro Val Ala Thr 370 375 380 Pro Lys Gln Gln Ala Gln Asn Ser Tyr Asn Lys Asp Asn Ser Lys Ser 385 390 395 400 Arg Ile Ser Ser Asn Pro Gln Ser Phe Thr Lys Gln Gln His Val Leu 405 410 415 Page 71 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Lys Ile Glu Pro Asn Ser Lys Tyr Ile Pro Glu Thr His Ser Asn 420 425 430 Leu Gln Arg Pro Ile Lys Ser Gln Ser Gln Thr Tyr Asp Ser Ile Ser 435 440 445 His Thr Gln Asn Ser Pro Phe Val Pro Tyr Ser Ser Ser Lys Ala Asn 450 455 460 Pro Lys Arg Ser Asn Asn Glu His Asn Leu Pro Asn His Tyr Thr Asn 465 470 475 480 Leu Ala Asn Lys Asn Ile Asn Tyr Gln Ser Gln Arg Asn Tyr Glu Gln 485 490 495 Glu Asn Asp Ala Tyr Ser Asp Asp Glu Asn Asp Thr Phe Cys Ser Lys 500 505 510 Ile Tyr Lys Tyr Cys Cys Cys Cys Phe Cys Cys Cys 515 520 <210> 46 <211> 1125 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1125) <400> 46 atg agg ata cag tcg ctt ttt gtt tta ttt aat gtt gcc atc atc gca 48 Met Arg Ile Gln Ser Leu Phe Val Leu Phe Asn Val Ala Ile Ile Ala 1 5 10 15 tgg tca tat cca tat gag cct tta agg gtt tta caa gta gga gag aat 96 Trp Ser Tyr Pro Tyr Glu Pro Leu Arg Val Leu Gln Val Gly Glu Asn 20 25 30 gag gta atg gag gtt ccc gaa tca gaa aag cta aac tta cga aga aga 144 Glu Val Met Glu Val Pro Glu Ser Glu Lys Leu Asn Leu Arg Arg Arg 35 40 45 ggt gtc aaa ttc ttt gat gtg acc aaa cac act tct ttc tta cct ttc 192 Gly Val Lys Phe Phe Asp Val Thr Lys His Thr Ser Phe Leu Pro Phe 50 55 60 ttt aac aag gag gaa gag cca aca gta cca acg tat aac tat cct cct 240 Phe Asn Lys Glu Glu Glu Pro Thr Val Pro Thr Tyr Asn Tyr Pro Pro 65 70 75 80 gag ata tcg aac aaa gaa gta gtg gat gat tcg att aag aat ata gac 288 Glu Ile Ser Asn Lys Glu Val Val Asp Asp Ser Ile Lys Asn Ile Asp 85 90 95 aag ggc tct atg cac aag aac ttg gca aag ttt aca agt ttt tac acc 336 Lys Gly Ser Met His Lys Asn Leu Ala Lys Phe Thr Ser Phe Tyr Thr 100 105 110 Page 72 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cgt tac tac aag tcc gat cac ggc ttt gaa tct gcc gag tgg tta gct 384 Arg Tyr Tyr Lys Ser Asp His Gly Phe Glu Ser Ala Glu Trp Leu Ala 115 120 125 gca act atc gct aat att aca aaa gat att ccg caa gat acg ttg act 432 Ala Thr Ile Ala Asn Ile Thr Lys Asp Ile Pro Gln Asp Thr Leu Thr 130 135 140 att gaa cat ttt gat cac aaa gaa tgg aag caa tat tca att ata gtc 480 Ile Glu His Phe Asp His Lys Glu Trp Lys Gln Tyr Ser Ile Ile Val 145 150 155 160 cgt gtc acg gga tct act acg cca gaa gat att ata ata att ggt tct 528 Arg Val Thr Gly Ser Thr Thr Pro Glu Asp Ile Ile Ile Ile Gly Ser 165 170 175 cat caa gat tct atc aat ctg cta ctg cca tcc ata atg gca gct cca 576 His Gln Asp Ser Ile Asn Leu Leu Leu Pro Ser Ile Met Ala Ala Pro 180 185 190 ggt gcg gac gac aat ggg tca ggc acg gtg act aat atg gag gct ctc 624 Gly Ala Asp Asp Asn Gly Ser Gly Thr Val Thr Asn Met Glu Ala Leu 195 200 205 aga tta tat acg gaa aat ttt ttg aag aga gga ttt aga cct aac aac 672 Arg Leu Tyr Thr Glu Asn Phe Leu Lys Arg Gly Phe Arg Pro Asn Asn 210 215 220 act gtg gaa ttt cac ttt tat tcc gcc gaa gag ggg gga ttg ttg ggt 720 Thr Val Glu Phe His Phe Tyr Ser Ala Glu Glu Gly Gly Leu Leu Gly 225 230 235 240 tct ctt gat gtt ttt aca gct tat gcc aaa cag aaa aag cat gtg aga 768 Ser Leu Asp Val Phe Thr Ala Tyr Ala Lys Gln Lys Lys His Val Arg 245 250 255 gcg atg ctt cag caa gac atg acg gga tat gtt tct gat cca gaa gat 816 Ala Met Leu Gln Gln Asp Met Thr Gly Tyr Val Ser Asp Pro Glu Asp 260 265 270 gaa cat gtg ggg att gtc acc gac tac act act ccc gca tta act gat 864 Glu His Val Gly Ile Val Thr Asp Tyr Thr Thr Pro Ala Leu Thr Asp 275 280 285 ttt ata aaa cta att atc aac tct tat cta tcc att cct tac agg gat 912 Phe Ile Lys Leu Ile Ile Asn Ser Tyr Leu Ser Ile Pro Tyr Arg Asp 290 295 300 aca caa tgt ggc tat gct tgt agc gat cat ggg agt gcc acc aga aac 960 Thr Gln Cys Gly Tyr Ala Cys Ser Asp His Gly Ser Ala Thr Arg Asn 305 310 315 320 gga ttt cca ggc tcc ttc gtg att gaa agt gag ttc aaa aag act aac 1008 Gly Phe Pro Gly Ser Phe Val Ile Glu Ser Glu Phe Lys Lys Thr Asn 325 330 335 aag tat att cac agc acc atg gat act ttg gac aga tta agt ctc gct 1056 Lys Tyr Ile His Ser Thr Met Asp Thr Leu Asp Arg Leu Ser Leu Ala 340 345 350 cat atg gcg gaa cac aca aaa att gta tta ggg gta atc att gaa ctc 1104 His Met Ala Glu His Thr Lys Ile Val Leu Gly Val Ile Ile Glu Leu 355 360 365 ggg tca tgg tcc gct tgg taa 1125 Gly Ser Trp Ser Ala Trp 370 Page 73 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 47 <211> 374 <212> PRT <213> Saccharomyces cerevisiae <400> 47 Met Arg Ile Gln Ser Leu Phe Val Leu Phe Asn Val Ala Ile Ile Ala 1 5 10 15 Trp Ser Tyr Pro Tyr Glu Pro Leu Arg Val Leu Gln Val Gly Glu Asn 20 25 30 Glu Val Met Glu Val Pro Glu Ser Glu Lys Leu Asn Leu Arg Arg Arg 35 40 45 Gly Val Lys Phe Phe Asp Val Thr Lys His Thr Ser Phe Leu Pro Phe 50 55 60 Phe Asn Lys Glu Glu Glu Pro Thr Val Pro Thr Tyr Asn Tyr Pro Pro 65 70 75 80 Glu Ile Ser Asn Lys Glu Val Val Asp Asp Ser Ile Lys Asn Ile Asp 85 90 95 Lys Gly Ser Met His Lys Asn Leu Ala Lys Phe Thr Ser Phe Tyr Thr 100 105 110 Arg Tyr Tyr Lys Ser Asp His Gly Phe Glu Ser Ala Glu Trp Leu Ala 115 120 125 Ala Thr Ile Ala Asn Ile Thr Lys Asp Ile Pro Gln Asp Thr Leu Thr 130 135 140 Ile Glu His Phe Asp His Lys Glu Trp Lys Gln Tyr Ser Ile Ile Val 145 150 155 160 Arg Val Thr Gly Ser Thr Thr Pro Glu Asp Ile Ile Ile Ile Gly Ser 165 170 175 His Gln Asp Ser Ile Asn Leu Leu Leu Pro Ser Ile Met Ala Ala Pro 180 185 190 Gly Ala Asp Asp Asn Gly Ser Gly Thr Val Thr Asn Met Glu Ala Leu 195 200 205 Arg Leu Tyr Thr Glu Asn Phe Leu Lys Arg Gly Phe Arg Pro Asn Asn 210 215 220 Thr Val Glu Phe His Phe Tyr Ser Ala Glu Glu Gly Gly Leu Leu Gly 225 230 235 240 Page 74 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Leu Asp Val Phe Thr Ala Tyr Ala Lys Gln Lys Lys His Val Arg 245 250 255 Ala Met Leu Gln Gln Asp Met Thr Gly Tyr Val Ser Asp Pro Glu Asp 260 265 270 Glu His Val Gly Ile Val Thr Asp Tyr Thr Thr Pro Ala Leu Thr Asp 275 280 285 Phe Ile Lys Leu Ile Ile Asn Ser Tyr Leu Ser Ile Pro Tyr Arg Asp 290 295 300 Thr Gln Cys Gly Tyr Ala Cys Ser Asp His Gly Ser Ala Thr Arg Asn 305 310 315 320 Gly Phe Pro Gly Ser Phe Val Ile Glu Ser Glu Phe Lys Lys Thr Asn 325 330 335 Lys Tyr Ile His Ser Thr Met Asp Thr Leu Asp Arg Leu Ser Leu Ala 340 345 350 His Met Ala Glu His Thr Lys Ile Val Leu Gly Val Ile Ile Glu Leu 355 360 365 Gly Ser Trp Ser Ala Trp 370 <210> 48 <211> 1530 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1530) <400> 48 atg atc gct ttg aag ccc aat gct gtt cga acc ttc cga caa gtg cag 48 Met Ile Ala Leu Lys Pro Asn Ala Val Arg Thr Phe Arg Gln Val Gln 1 5 10 15 cat tgc agc ttt cgc att tgt cgg tat caa tct acg aag tca aat aag 96 His Cys Ser Phe Arg Ile Cys Arg Tyr Gln Ser Thr Lys Ser Asn Lys 20 25 30 tgt ctg acg ccc ttg caa gag tac gac aga ctg gtg aag ttg ggg aag 144 Cys Leu Thr Pro Leu Gln Glu Tyr Asp Arg Leu Val Lys Leu Gly Lys 35 40 45 cta cgg gat gat aca tat cag cgt ggt atc atc tct tcc tta ggg gat 192 Leu Arg Asp Asp Thr Tyr Gln Arg Gly Ile Ile Ser Ser Leu Gly Asp 50 55 60 ttg tat gat tca ctg gtt aaa tat gta cct ccg gtt gtc aag aca ccc 240 Leu Tyr Asp Ser Leu Val Lys Tyr Val Pro Pro Val Val Lys Thr Pro 65 70 75 80 Page 75 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aat gct gtc gac caa gtt ggc ggt tgg ttg aat ggt ctt aaa tcc gta 288 Asn Ala Val Asp Gln Val Gly Gly Trp Leu Asn Gly Leu Lys Ser Val 85 90 95 ttt agc cgt ggc aaa cct aag aac att ggg gcg tat gtg gat gta tcc 336 Phe Ser Arg Gly Lys Pro Lys Asn Ile Gly Ala Tyr Val Asp Val Ser 100 105 110 aaa att ggt aac tcg ata cct cga gga gtt tac cta tat gga gat gtt 384 Lys Ile Gly Asn Ser Ile Pro Arg Gly Val Tyr Leu Tyr Gly Asp Val 115 120 125 ggc tgc gga aag aca atg ttg atg gac ctt ttt tat act aca att ccc 432 Gly Cys Gly Lys Thr Met Leu Met Asp Leu Phe Tyr Thr Thr Ile Pro 130 135 140 aat cat tta aca aaa aag aga ata cat ttt cac cag ttt atg caa tat 480 Asn His Leu Thr Lys Lys Arg Ile His Phe His Gln Phe Met Gln Tyr 145 150 155 160 gtt cac aaa agg tcg cat gaa att gtt aga gag caa aat ttg aaa gaa 528 Val His Lys Arg Ser His Glu Ile Val Arg Glu Gln Asn Leu Lys Glu 165 170 175 cta ggt gat gca aaa gga aaa gag atc gat acg gtt cca ttt ttg gcc 576 Leu Gly Asp Ala Lys Gly Lys Glu Ile Asp Thr Val Pro Phe Leu Ala 180 185 190 gca gag att gca aat aat tcg cat gtt ctt tgt ttt gac gag ttt caa 624 Ala Glu Ile Ala Asn Asn Ser His Val Leu Cys Phe Asp Glu Phe Gln 195 200 205 gtc act gac gtg gca gat gca atg ata ttg aga agg ctg atg act gcc 672 Val Thr Asp Val Ala Asp Ala Met Ile Leu Arg Arg Leu Met Thr Ala 210 215 220 tta cta tcc gat gat tat ggt gtc gta ctt ttc gca acc tcg aat aga 720 Leu Leu Ser Asp Asp Tyr Gly Val Val Leu Phe Ala Thr Ser Asn Arg 225 230 235 240 cat cca gat gag ttg tat atc aac ggt gtt caa aga caa tca ttt att 768 His Pro Asp Glu Leu Tyr Ile Asn Gly Val Gln Arg Gln Ser Phe Ile 245 250 255 cct tgt att gaa ctg ata aag cat aga act aag gtt atc ttc ttg aat 816 Pro Cys Ile Glu Leu Ile Lys His Arg Thr Lys Val Ile Phe Leu Asn 260 265 270 tcg cca aca gat tac cgt aag att cca aga cct gtg tcc tca gtt tac 864 Ser Pro Thr Asp Tyr Arg Lys Ile Pro Arg Pro Val Ser Ser Val Tyr 275 280 285 tat ttc cca tcc gat acg agc ata aaa tac gca tca aag gaa tgt aaa 912 Tyr Phe Pro Ser Asp Thr Ser Ile Lys Tyr Ala Ser Lys Glu Cys Lys 290 295 300 acc cgt cga gaa act cat att aag gaa tgg tat aac tat ttc gca cag 960 Thr Arg Arg Glu Thr His Ile Lys Glu Trp Tyr Asn Tyr Phe Ala Gln 305 310 315 320 gct tcc cac acc gat gat tcc act gat tca cac acg gtg cat aag aca 1008 Ala Ser His Thr Asp Asp Ser Thr Asp Ser His Thr Val His Lys Thr 325 330 335 ttt tat gat tat cca tta act att tgg ggg aga gag ttc aaa gtc cct 1056 Phe Tyr Asp Tyr Pro Leu Thr Ile Trp Gly Arg Glu Phe Lys Val Pro 340 345 350 Page 76 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag tgt acc cca cct cga gtc gcg cag ttt act ttc aag cag ttg tgt 1104 Lys Cys Thr Pro Pro Arg Val Ala Gln Phe Thr Phe Lys Gln Leu Cys 355 360 365 ggt gag cct ttg gcc gca gga gat tac ttg acg ttg gca aaa aat ttt 1152 Gly Glu Pro Leu Ala Ala Gly Asp Tyr Leu Thr Leu Ala Lys Asn Phe 370 375 380 gaa gcc ttt ata gtg acc gat att cca tat ttg tcc att tac gtt cgt 1200 Glu Ala Phe Ile Val Thr Asp Ile Pro Tyr Leu Ser Ile Tyr Val Arg 385 390 395 400 gat gaa gtg aga aga ttt att aca ttt tta gat gct gta tat gac agt 1248 Asp Glu Val Arg Arg Phe Ile Thr Phe Leu Asp Ala Val Tyr Asp Ser 405 410 415 ggc ggg aaa ctg gcc act acg ggt gca gcg gat ttt tct tcc ttg ttt 1296 Gly Gly Lys Leu Ala Thr Thr Gly Ala Ala Asp Phe Ser Ser Leu Phe 420 425 430 gtg gaa cct gaa cag ata ctt aat gat ttt gag tta cgc cca aca acc 1344 Val Glu Pro Glu Gln Ile Leu Asn Asp Phe Glu Leu Arg Pro Thr Thr 435 440 445 aaa gaa cct gat agc gtc gat act ggt atg gta gat gag atg gtt gag 1392 Lys Glu Pro Asp Ser Val Asp Thr Gly Met Val Asp Glu Met Val Glu 450 455 460 aaa cac ggt ttt tcg aaa gag att gcc aag aaa tcg cag atg ttt gct 1440 Lys His Gly Phe Ser Lys Glu Ile Ala Lys Lys Ser Gln Met Phe Ala 465 470 475 480 ctt gat gaa gaa aga ttt gcc ttt gcc cgt gcc tta agc agg ctg tca 1488 Leu Asp Glu Glu Arg Phe Ala Phe Ala Arg Ala Leu Ser Arg Leu Ser 485 490 495 cag atg agc tcc acc gat tgg gtt act aag cct aca tac taa 1530 Gln Met Ser Ser Thr Asp Trp Val Thr Lys Pro Thr Tyr 500 505 <210> 49 <211> 509 <212> PRT <213> Saccharomyces cerevisiae <400> 49 Met Ile Ala Leu Lys Pro Asn Ala Val Arg Thr Phe Arg Gln Val Gln 1 5 10 15 His Cys Ser Phe Arg Ile Cys Arg Tyr Gln Ser Thr Lys Ser Asn Lys 20 25 30 Cys Leu Thr Pro Leu Gln Glu Tyr Asp Arg Leu Val Lys Leu Gly Lys 35 40 45 Leu Arg Asp Asp Thr Tyr Gln Arg Gly Ile Ile Ser Ser Leu Gly Asp 50 55 60 Leu Tyr Asp Ser Leu Val Lys Tyr Val Pro Pro Val Val Lys Thr Pro 65 70 75 80 Page 77 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Ala Val Asp Gln Val Gly Gly Trp Leu Asn Gly Leu Lys Ser Val 85 90 95 Phe Ser Arg Gly Lys Pro Lys Asn Ile Gly Ala Tyr Val Asp Val Ser 100 105 110 Lys Ile Gly Asn Ser Ile Pro Arg Gly Val Tyr Leu Tyr Gly Asp Val 115 120 125 Gly Cys Gly Lys Thr Met Leu Met Asp Leu Phe Tyr Thr Thr Ile Pro 130 135 140 Asn His Leu Thr Lys Lys Arg Ile His Phe His Gln Phe Met Gln Tyr 145 150 155 160 Val His Lys Arg Ser His Glu Ile Val Arg Glu Gln Asn Leu Lys Glu 165 170 175 Leu Gly Asp Ala Lys Gly Lys Glu Ile Asp Thr Val Pro Phe Leu Ala 180 185 190 Ala Glu Ile Ala Asn Asn Ser His Val Leu Cys Phe Asp Glu Phe Gln 195 200 205 Val Thr Asp Val Ala Asp Ala Met Ile Leu Arg Arg Leu Met Thr Ala 210 215 220 Leu Leu Ser Asp Asp Tyr Gly Val Val Leu Phe Ala Thr Ser Asn Arg 225 230 235 240 His Pro Asp Glu Leu Tyr Ile Asn Gly Val Gln Arg Gln Ser Phe Ile 245 250 255 Pro Cys Ile Glu Leu Ile Lys His Arg Thr Lys Val Ile Phe Leu Asn 260 265 270 Ser Pro Thr Asp Tyr Arg Lys Ile Pro Arg Pro Val Ser Ser Val Tyr 275 280 285 Tyr Phe Pro Ser Asp Thr Ser Ile Lys Tyr Ala Ser Lys Glu Cys Lys 290 295 300 Thr Arg Arg Glu Thr His Ile Lys Glu Trp Tyr Asn Tyr Phe Ala Gln 305 310 315 320 Ala Ser His Thr Asp Asp Ser Thr Asp Ser His Thr Val His Lys Thr 325 330 335 Phe Tyr Asp Tyr Pro Leu Thr Ile Trp Gly Arg Glu Phe Lys Val Pro 340 345 350 Page 78 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Cys Thr Pro Pro Arg Val Ala Gln Phe Thr Phe Lys Gln Leu Cys 355 360 365 Gly Glu Pro Leu Ala Ala Gly Asp Tyr Leu Thr Leu Ala Lys Asn Phe 370 375 380 Glu Ala Phe Ile Val Thr Asp Ile Pro Tyr Leu Ser Ile Tyr Val Arg 385 390 395 400 Asp Glu Val Arg Arg Phe Ile Thr Phe Leu Asp Ala Val Tyr Asp Ser 405 410 415 Gly Gly Lys Leu Ala Thr Thr Gly Ala Ala Asp Phe Ser Ser Leu Phe 420 425 430 Val Glu Pro Glu Gln Ile Leu Asn Asp Phe Glu Leu Arg Pro Thr Thr 435 440 445 Lys Glu Pro Asp Ser Val Asp Thr Gly Met Val Asp Glu Met Val Glu 450 455 460 Lys His Gly Phe Ser Lys Glu Ile Ala Lys Lys Ser Gln Met Phe Ala 465 470 475 480 Leu Asp Glu Glu Arg Phe Ala Phe Ala Arg Ala Leu Ser Arg Leu Ser 485 490 495 Gln Met Ser Ser Thr Asp Trp Val Thr Lys Pro Thr Tyr 500 505 <210> 50 <211> 1710 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1710) <400> 50 atg aag gat tta aaa tta tcg aat ttc aaa ggc aaa ttt ata agc aga 48 Met Lys Asp Leu Lys Leu Ser Asn Phe Lys Gly Lys Phe Ile Ser Arg 1 5 10 15 acc agt cac tgg gga ctt acg ggt aag aag ttg cgg tat ttc atc act 96 Thr Ser His Trp Gly Leu Thr Gly Lys Lys Leu Arg Tyr Phe Ile Thr 20 25 30 atc gca tct atg acg ggc ttc tcc ctg ttt gga tac gac caa ggg ttg 144 Ile Ala Ser Met Thr Gly Phe Ser Leu Phe Gly Tyr Asp Gln Gly Leu 35 40 45 atg gca agt cta att act ggt aaa cag ttc aac tat gaa ttt cca gca 192 Met Ala Ser Leu Ile Thr Gly Lys Gln Phe Asn Tyr Glu Phe Pro Ala 50 55 60 Page 79 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt acc aaa gaa aat ggc gat cat gac aga cac gca act gta gtg cag ggc 240 Thr Lys Glu Asn Gly Asp His Asp Arg His Ala Thr Val Val Gln Gly 65 70 75 80 gct aca acc tcc tgt tat gaa tta ggt tgt ttc gca ggt tct cta ttc 288 Ala Thr Thr Ser Cys Tyr Glu Leu Gly Cys Phe Ala Gly Ser Leu Phe 85 90 95 gtt atg ttc tgc ggt gaa aga att ggt aga aaa cca tta atc ctg atg 336 Val Met Phe Cys Gly Glu Arg Ile Gly Arg Lys Pro Leu Ile Leu Met 100 105 110 ggt tcc gta ata acc atc att ggt gcc gtt att tct aca tgc gca ttt 384 Gly Ser Val Ile Thr Ile Ile Gly Ala Val Ile Ser Thr Cys Ala Phe 115 120 125 cgt ggt tac tgg gca tta ggc cag ttt atc atc gga aga gtc gtc acc 432 Arg Gly Tyr Trp Ala Leu Gly Gln Phe Ile Ile Gly Arg Val Val Thr 130 135 140 ggt gtt gga aca ggg ttg aat aca tct act att ccc gtt tgg caa tca 480 Gly Val Gly Thr Gly Leu Asn Thr Ser Thr Ile Pro Val Trp Gln Ser 145 150 155 160 gaa atg tca aaa gct gaa aat aga ggg ttg ctg gtc aat tta gaa ggt 528 Glu Met Ser Lys Ala Glu Asn Arg Gly Leu Leu Val Asn Leu Glu Gly 165 170 175 tcc aca att gct ttt ggt act atg att gct tat tgg att gat ttt ggg 576 Ser Thr Ile Ala Phe Gly Thr Met Ile Ala Tyr Trp Ile Asp Phe Gly 180 185 190 ttg tct tat acc aac agt tct gtt cag tgg aga ttc ccc gtg tca atg 624 Leu Ser Tyr Thr Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ser Met 195 200 205 caa atc gtt ttt gct ctc ttc ctg ctt gct ttc atg att aaa cta cct 672 Gln Ile Val Phe Ala Leu Phe Leu Leu Ala Phe Met Ile Lys Leu Pro 210 215 220 gaa tcg cca cgt tgg ctg att tct caa agt cga aca gaa gaa gct cgc 720 Glu Ser Pro Arg Trp Leu Ile Ser Gln Ser Arg Thr Glu Glu Ala Arg 225 230 235 240 tac ttg gta gga aca cta gac gac gcg gat cca aat gat gag gaa gtt 768 Tyr Leu Val Gly Thr Leu Asp Asp Ala Asp Pro Asn Asp Glu Glu Val 245 250 255 ata aca gaa gtt gct atg ctt cac gat gct gtt aac agg acc aaa cac 816 Ile Thr Glu Val Ala Met Leu His Asp Ala Val Asn Arg Thr Lys His 260 265 270 gag aaa cat tca ctg tca agt ttg ttc tcc aga ggc agg tcc caa aat 864 Glu Lys His Ser Leu Ser Ser Leu Phe Ser Arg Gly Arg Ser Gln Asn 275 280 285 ctt cag agg gct ttg att gca gct tca acg caa ttt ttc cag caa ttt 912 Leu Gln Arg Ala Leu Ile Ala Ala Ser Thr Gln Phe Phe Gln Gln Phe 290 295 300 act ggt tgt aac gct gcc ata tac tac tct act gta tta ttc aac aaa 960 Thr Gly Cys Asn Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Asn Lys 305 310 315 320 aca att aaa tta gac tat aga tta tca atg atc ata ggt ggg gtc ttc 1008 Thr Ile Lys Leu Asp Tyr Arg Leu Ser Met Ile Ile Gly Gly Val Phe 325 330 335 Page 80 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gca aca atc tac gcc tta tct act att ggt tca ttt ttt cta att gaa 1056 Ala Thr Ile Tyr Ala Leu Ser Thr Ile Gly Ser Phe Phe Leu Ile Glu 340 345 350 aag cta ggt aga cgt aag ctg ttt tta tta ggt gcc aca ggt caa gca 1104 Lys Leu Gly Arg Arg Lys Leu Phe Leu Leu Gly Ala Thr Gly Gln Ala 355 360 365 gtt tca ttc aca att aca ttt gca tgc ttg gtc aaa gaa aat aaa gaa 1152 Val Ser Phe Thr Ile Thr Phe Ala Cys Leu Val Lys Glu Asn Lys Glu 370 375 380 aac gca aga ggt gct gcc gtc ggc tta ttt ttg ttc att aca ttc ttt 1200 Asn Ala Arg Gly Ala Ala Val Gly Leu Phe Leu Phe Ile Thr Phe Phe 385 390 395 400 ggt ttg tct ttg cta tca tta cca tgg ata tac cca cca gaa att gca 1248 Gly Leu Ser Leu Leu Ser Leu Pro Trp Ile Tyr Pro Pro Glu Ile Ala 405 410 415 tca atg aaa gtt cgt gca tca aca aac gct ttc tcc aca tgt act aat 1296 Ser Met Lys Val Arg Ala Ser Thr Asn Ala Phe Ser Thr Cys Thr Asn 420 425 430 tgg ttg tgt aac ttt gcg gtt gtc atg ttc acc cca ata ttt att gga 1344 Trp Leu Cys Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Gly 435 440 445 cag tcc ggt tgg ggt tgc tac tta ttt ttt gct gtt atg aat tat tta 1392 Gln Ser Gly Trp Gly Cys Tyr Leu Phe Phe Ala Val Met Asn Tyr Leu 450 455 460 tac att cca gtt atc ttc ttt ttc tac cct gaa acc gcc gga aga agt 1440 Tyr Ile Pro Val Ile Phe Phe Phe Tyr Pro Glu Thr Ala Gly Arg Ser 465 470 475 480 ttg gag gaa atc gac atc atc ttt gct aaa gca tac gag gat ggc act 1488 Leu Glu Glu Ile Asp Ile Ile Phe Ala Lys Ala Tyr Glu Asp Gly Thr 485 490 495 caa cca tgg aga gtt gct aac cat ttg ccc aag tta tcc cta caa gaa 1536 Gln Pro Trp Arg Val Ala Asn His Leu Pro Lys Leu Ser Leu Gln Glu 500 505 510 gtc gaa gat cat gcc aat gca ttg ggc tct tat gac gac gaa atg gaa 1584 Val Glu Asp His Ala Asn Ala Leu Gly Ser Tyr Asp Asp Glu Met Glu 515 520 525 aaa gag gac ttt ggt gaa gat aga gta gaa gac acc tat aac caa att 1632 Lys Glu Asp Phe Gly Glu Asp Arg Val Glu Asp Thr Tyr Asn Gln Ile 530 535 540 aac ggc gat aat tcg tct agt tct tca aac atc aaa aat gaa gat aca 1680 Asn Gly Asp Asn Ser Ser Ser Ser Ser Asn Ile Lys Asn Glu Asp Thr 545 550 555 560 gtg aac gat aaa gca aat ttt gag ggt tga 1710 Val Asn Asp Lys Ala Asn Phe Glu Gly 565 <210> 51 <211> 569 <212> PRT <213> Saccharomyces cerevisiae <400> 51 Page 81 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Lys Asp Leu Lys Leu Ser Asn Phe Lys Gly Lys Phe Ile Ser Arg 1 5 10 15 Thr Ser His Trp Gly Leu Thr Gly Lys Lys Leu Arg Tyr Phe Ile Thr 20 25 30 Ile Ala Ser Met Thr Gly Phe Ser Leu Phe Gly Tyr Asp Gln Gly Leu 35 40 45 Met Ala Ser Leu Ile Thr Gly Lys Gln Phe Asn Tyr Glu Phe Pro Ala 50 55 60 Thr Lys Glu Asn Gly Asp His Asp Arg His Ala Thr Val Val Gln Gly 65 70 75 80 Ala Thr Thr Ser Cys Tyr Glu Leu Gly Cys Phe Ala Gly Ser Leu Phe 85 90 95 Val Met Phe Cys Gly Glu Arg Ile Gly Arg Lys Pro Leu Ile Leu Met 100 105 110 Gly Ser Val Ile Thr Ile Ile Gly Ala Val Ile Ser Thr Cys Ala Phe 115 120 125 Arg Gly Tyr Trp Ala Leu Gly Gln Phe Ile Ile Gly Arg Val Val Thr 130 135 140 Gly Val Gly Thr Gly Leu Asn Thr Ser Thr Ile Pro Val Trp Gln Ser 145 150 155 160 Glu Met Ser Lys Ala Glu Asn Arg Gly Leu Leu Val Asn Leu Glu Gly 165 170 175 Ser Thr Ile Ala Phe Gly Thr Met Ile Ala Tyr Trp Ile Asp Phe Gly 180 185 190 Leu Ser Tyr Thr Asn Ser Ser Val Gln Trp Arg Phe Pro Val Ser Met 195 200 205 Gln Ile Val Phe Ala Leu Phe Leu Leu Ala Phe Met Ile Lys Leu Pro 210 215 220 Glu Ser Pro Arg Trp Leu Ile Ser Gln Ser Arg Thr Glu Glu Ala Arg 225 230 235 240 Tyr Leu Val Gly Thr Leu Asp Asp Ala Asp Pro Asn Asp Glu Glu Val 245 250 255 Ile Thr Glu Val Ala Met Leu His Asp Ala Val Asn Arg Thr Lys His 260 265 270 Page 82 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Lys His Ser Leu Ser Ser Leu Phe Ser Arg Gly Arg Ser Gln Asn 275 280 285 Leu Gln Arg Ala Leu Ile Ala Ala Ser Thr Gln Phe Phe Gln Gln Phe 290 295 300 Thr Gly Cys Asn Ala Ala Ile Tyr Tyr Ser Thr Val Leu Phe Asn Lys 305 310 315 320 Thr Ile Lys Leu Asp Tyr Arg Leu Ser Met Ile Ile Gly Gly Val Phe 325 330 335 Ala Thr Ile Tyr Ala Leu Ser Thr Ile Gly Ser Phe Phe Leu Ile Glu 340 345 350 Lys Leu Gly Arg Arg Lys Leu Phe Leu Leu Gly Ala Thr Gly Gln Ala 355 360 365 Val Ser Phe Thr Ile Thr Phe Ala Cys Leu Val Lys Glu Asn Lys Glu 370 375 380 Asn Ala Arg Gly Ala Ala Val Gly Leu Phe Leu Phe Ile Thr Phe Phe 385 390 395 400 Gly Leu Ser Leu Leu Ser Leu Pro Trp Ile Tyr Pro Pro Glu Ile Ala 405 410 415 Ser Met Lys Val Arg Ala Ser Thr Asn Ala Phe Ser Thr Cys Thr Asn 420 425 430 Trp Leu Cys Asn Phe Ala Val Val Met Phe Thr Pro Ile Phe Ile Gly 435 440 445 Gln Ser Gly Trp Gly Cys Tyr Leu Phe Phe Ala Val Met Asn Tyr Leu 450 455 460 Tyr Ile Pro Val Ile Phe Phe Phe Tyr Pro Glu Thr Ala Gly Arg Ser 465 470 475 480 Leu Glu Glu Ile Asp Ile Ile Phe Ala Lys Ala Tyr Glu Asp Gly Thr 485 490 495 Gln Pro Trp Arg Val Ala Asn His Leu Pro Lys Leu Ser Leu Gln Glu 500 505 510 Val Glu Asp His Ala Asn Ala Leu Gly Ser Tyr Asp Asp Glu Met Glu 515 520 525 Lys Glu Asp Phe Gly Glu Asp Arg Val Glu Asp Thr Tyr Asn Gln Ile 530 535 540 Page 83 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Gly Asp Asn Ser Ser Ser Ser Ser Asn Ile Lys Asn Glu Asp Thr 545 550 555 560 Val Asn Asp Lys Ala Asn Phe Glu Gly 565 <210> 52 <211> 432 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(432) <400> 52 atg gag acc aat ttt tcc ttc gac tcg aat tta att gtt att atc att 48 Met Glu Thr Asn Phe Ser Phe Asp Ser Asn Leu Ile Val Ile Ile Ile 1 5 10 15 atc acg ttg ttt gcc aca aga att att gct aaa aga ttt tta tct act 96 Ile Thr Leu Phe Ala Thr Arg Ile Ile Ala Lys Arg Phe Leu Ser Thr 20 25 30 cca aaa atg gta tcc cag gaa aca gtt gct cac gta aag gat ctg att 144 Pro Lys Met Val Ser Gln Glu Thr Val Ala His Val Lys Asp Leu Ile 35 40 45 ggc caa aag gaa gtg ttt gtt gca gca aag aca tac tgc cct tac tgt 192 Gly Gln Lys Glu Val Phe Val Ala Ala Lys Thr Tyr Cys Pro Tyr Cys 50 55 60 aaa gct act ttg tct acc ctc ttc caa gaa ttg aac gtt ccc aaa tcc 240 Lys Ala Thr Leu Ser Thr Leu Phe Gln Glu Leu Asn Val Pro Lys Ser 65 70 75 80 aag gcc ctt gtg ttg gaa tta gat gaa atg agc aat ggc tca gag att 288 Lys Ala Leu Val Leu Glu Leu Asp Glu Met Ser Asn Gly Ser Glu Ile 85 90 95 caa gac gct tta gaa gaa atc tcg ggc caa aaa act gta cct aac gta 336 Gln Asp Ala Leu Glu Glu Ile Ser Gly Gln Lys Thr Val Pro Asn Val 100 105 110 tac atc aat ggc aag cac att ggt ggt aac agc gat ttg gaa act ttg 384 Tyr Ile Asn Gly Lys His Ile Gly Gly Asn Ser Asp Leu Glu Thr Leu 115 120 125 aag aaa aat ggc aag tta gct gaa ata ttg aag ccg gta ttt caa tag 432 Lys Lys Asn Gly Lys Leu Ala Glu Ile Leu Lys Pro Val Phe Gln 130 135 140 <210> 53 <211> 143 <212> PRT <213> Saccharomyces cerevisiae <400> 53 Met Glu Thr Asn Phe Ser Phe Asp Ser Asn Leu Ile Val Ile Ile Ile 1 5 10 15 Page 84 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Thr Leu Phe Ala Thr Arg Ile Ile Ala Lys Arg Phe Leu Ser Thr 20 25 30 Pro Lys Met Val Ser Gln Glu Thr Val Ala His Val Lys Asp Leu Ile 35 40 45 Gly Gln Lys Glu Val Phe Val Ala Ala Lys Thr Tyr Cys Pro Tyr Cys 50 55 60 Lys Ala Thr Leu Ser Thr Leu Phe Gln Glu Leu Asn Val Pro Lys Ser 65 70 75 80 Lys Ala Leu Val Leu Glu Leu Asp Glu Met Ser Asn Gly Ser Glu Ile 85 90 95 Gln Asp Ala Leu Glu Glu Ile Ser Gly Gln Lys Thr Val Pro Asn Val 100 105 110 Tyr Ile Asn Gly Lys His Ile Gly Gly Asn Ser Asp Leu Glu Thr Leu 115 120 125 Lys Lys Asn Gly Lys Leu Ala Glu Ile Leu Lys Pro Val Phe Gln 130 135 140 <210> 54 <211> 426 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(426) <400> 54 atg aaa tgt cac gcg aaa cgg acc ctt gcc ttt ttg gcg acg gca ctt 48 Met Lys Cys His Ala Lys Arg Thr Leu Ala Phe Leu Ala Thr Ala Leu 1 5 10 15 ccc cta tct gga aaa agc cga gca tgc acc cgt acc cca caa agc ttc 96 Pro Leu Ser Gly Lys Ser Arg Ala Cys Thr Arg Thr Pro Gln Ser Phe 20 25 30 gct tcc ggt ttc cgg gca gca gcg ccg ttt ctt ttt tcc cgc tgc ttc 144 Ala Ser Gly Phe Arg Ala Ala Ala Pro Phe Leu Phe Ser Arg Cys Phe 35 40 45 gcc ctt tgt att act cat tgc gca ctt ttt cac ttg cca tat tcg ttc 192 Ala Leu Cys Ile Thr His Cys Ala Leu Phe His Leu Pro Tyr Ser Phe 50 55 60 acc ggt ttt tct ttt tat ttc ttc gtc ttt ttt cgt ctt ttt ctt cac 240 Thr Gly Phe Ser Phe Tyr Phe Phe Val Phe Phe Arg Leu Phe Leu His 65 70 75 80 tgg ata tac gct ttt tgc att tgc aat agc aca tat gtg tat ata tat 288 Trp Ile Tyr Ala Phe Cys Ile Cys Asn Ser Thr Tyr Val Tyr Ile Tyr 85 90 95 aag caa gtg ttg agc ttg cct gtc aaa tcc tcc atg tgt cct tct cgt 336 Page 85 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Gln Val Leu Ser Leu Pro Val Lys Ser Ser Met Cys Pro Ser Arg 100 105 110 cta tct tgt tct gtc tgg tat aga gta ata ctt aca tac ata tac gta 384 Leu Ser Cys Ser Val Trp Tyr Arg Val Ile Leu Thr Tyr Ile Tyr Val 115 120 125 cat tgt ttc cgc tgg cta gtt cgt aac cac ctc ctt tcc tag 426 His Cys Phe Arg Trp Leu Val Arg Asn His Leu Leu Ser 130 135 140 <210> 55 <211> 141 <212> PRT <213> Saccharomyces cerevisiae <400> 55 Met Lys Cys His Ala Lys Arg Thr Leu Ala Phe Leu Ala Thr Ala Leu 1 5 10 15 Pro Leu Ser Gly Lys Ser Arg Ala Cys Thr Arg Thr Pro Gln Ser Phe 20 25 30 Ala Ser Gly Phe Arg Ala Ala Ala Pro Phe Leu Phe Ser Arg Cys Phe 35 40 45 Ala Leu Cys Ile Thr His Cys Ala Leu Phe His Leu Pro Tyr Ser Phe 50 55 60 Thr Gly Phe Ser Phe Tyr Phe Phe Val Phe Phe Arg Leu Phe Leu His 65 70 75 80 Trp Ile Tyr Ala Phe Cys Ile Cys Asn Ser Thr Tyr Val Tyr Ile Tyr 85 90 95 Lys Gln Val Leu Ser Leu Pro Val Lys Ser Ser Met Cys Pro Ser Arg 100 105 110 Leu Ser Cys Ser Val Trp Tyr Arg Val Ile Leu Thr Tyr Ile Tyr Val 115 120 125 His Cys Phe Arg Trp Leu Val Arg Asn His Leu Leu Ser 130 135 140 <210> 56 <211> 1488 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1488) <400> 56 atg aaa act gat aga tta ctg att aac gct tcc ccg gag aca tgt acc 48 Page 86 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Lys Thr Asp Arg Leu Leu Ile Asn Ala Ser Pro Glu Thr Cys Thr 1 5 10 15 aag gga gat gct gag atg gat act atg gat act att gac aga atg aca 96 Lys Gly Asp Ala Glu Met Asp Thr Met Asp Thr Ile Asp Arg Met Thr 20 25 30 tca gtt aaa gtt tta gcg gaa ggc aag gta tta agc aac ttc gaa gaa 144 Ser Val Lys Val Leu Ala Glu Gly Lys Val Leu Ser Asn Phe Glu Glu 35 40 45 ccg ggc tta atg agg tgc ggt tat cat gat gca aaa aac tgg gtc aga 192 Pro Gly Leu Met Arg Cys Gly Tyr His Asp Ala Lys Asn Trp Val Arg 50 55 60 aga tta tcg agc gaa aca att gtc ggt gag gac acg agt aat tta tac 240 Arg Leu Ser Ser Glu Thr Ile Val Gly Glu Asp Thr Ser Asn Leu Tyr 65 70 75 80 cca ttt tat gtt gat act gca tac gat gta agg cgt ttg aga aag gat 288 Pro Phe Tyr Val Asp Thr Ala Tyr Asp Val Arg Arg Leu Arg Lys Asp 85 90 95 ctt ata aat gct aag gtt gac ttg cag gtt gaa aac ctg ata ata atc 336 Leu Ile Asn Ala Lys Val Asp Leu Gln Val Glu Asn Leu Ile Ile Ile 100 105 110 tgc aat att aat gat att tcc act gta ttt ctc atg aga gaa gtg gtg 384 Cys Asn Ile Asn Asp Ile Ser Thr Val Phe Leu Met Arg Glu Val Val 115 120 125 gaa tgg atc tta cgc aat ttc cat tca ata act gta tat gta caa gat 432 Glu Trp Ile Leu Arg Asn Phe His Ser Ile Thr Val Tyr Val Gln Asp 130 135 140 att ttt aaa aag tca act cag ttt gct gtt ggt gac ctc tgc aaa gac 480 Ile Phe Lys Lys Ser Thr Gln Phe Ala Val Gly Asp Leu Cys Lys Asp 145 150 155 160 agc aat tgc agt aaa aac aga gta aag tat tgg tca aaa gaa ttt gtt 528 Ser Asn Cys Ser Lys Asn Arg Val Lys Tyr Trp Ser Lys Glu Phe Val 165 170 175 aaa aaa cac gat tca ttc ttt gac ttg atg att aca cta ggg ggt gat 576 Lys Lys His Asp Ser Phe Phe Asp Leu Met Ile Thr Leu Gly Gly Asp 180 185 190 gga act gtc ctt ttt gct tca tct ata ttc acg aaa gat gtt ccg ccg 624 Gly Thr Val Leu Phe Ala Ser Ser Ile Phe Thr Lys Asp Val Pro Pro 195 200 205 att gtt cca ttt gcc ctt gga tca tta gga ttt cta aca aat ttt gaa 672 Ile Val Pro Phe Ala Leu Gly Ser Leu Gly Phe Leu Thr Asn Phe Glu 210 215 220 ttt caa aat ttc aaa gaa acg ttg aaa cat atc tta aca gat gag gtt 720 Phe Gln Asn Phe Lys Glu Thr Leu Lys His Ile Leu Thr Asp Glu Val 225 230 235 240 cgt att aat tta cga atg agg ttg caa tgc aaa ctc tac cgt aga aat 768 Arg Ile Asn Leu Arg Met Arg Leu Gln Cys Lys Leu Tyr Arg Arg Asn 245 250 255 aaa cca gaa att gat gcc gca act ggg aga aaa ata tgt tac atc gat 816 Lys Pro Glu Ile Asp Ala Ala Thr Gly Arg Lys Ile Cys Tyr Ile Asp 260 265 270 ttc atc tcc gaa cat cac gta ttg aac gaa gta acc ata gat aga ggt 864 Page 87 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Ile Ser Glu His His Val Leu Asn Glu Val Thr Ile Asp Arg Gly 275 280 285 cca gct cct tgt tta tcc cta tta gaa ctc tat gga aac gac tca cta 912 Pro Ala Pro Cys Leu Ser Leu Leu Glu Leu Tyr Gly Asn Asp Ser Leu 290 295 300 atg act aag gtt cag gga gat gga ttg att gtt gcc acg cct acg gga 960 Met Thr Lys Val Gln Gly Asp Gly Leu Ile Val Ala Thr Pro Thr Gly 305 310 315 320 tcc acg gca tac tca ttg agt gca gga ggc tct tta ata tcg cca agc 1008 Ser Thr Ala Tyr Ser Leu Ser Ala Gly Gly Ser Leu Ile Ser Pro Ser 325 330 335 gta aat gcc ata gcg gtg acg cct ata tgt cct cat act ttg agc ttt 1056 Val Asn Ala Ile Ala Val Thr Pro Ile Cys Pro His Thr Leu Ser Phe 340 345 350 agg cct ata att tta cca gat agc atg gaa tta aaa gtt aga gta gat 1104 Arg Pro Ile Ile Leu Pro Asp Ser Met Glu Leu Lys Val Arg Val Asp 355 360 365 atg aac tca aga ggg acg tcg tgg gtg aat ttt gac gga aaa gat aga 1152 Met Asn Ser Arg Gly Thr Ser Trp Val Asn Phe Asp Gly Lys Asp Arg 370 375 380 gtt gaa ttg aaa cag ggt gac tat gtt gtg ata act gca agc ccc tat 1200 Val Glu Leu Lys Gln Gly Asp Tyr Val Val Ile Thr Ala Ser Pro Tyr 385 390 395 400 tcg gta ccg act atc gag tca tct gcc agt gaa ttt ttt gaa agt atc 1248 Ser Val Pro Thr Ile Glu Ser Ser Ala Ser Glu Phe Phe Glu Ser Ile 405 410 415 agt aaa aat ctt aat tgg aat gac cgc gaa gag cag aag cca ttt gca 1296 Ser Lys Asn Leu Asn Trp Asn Asp Arg Glu Glu Gln Lys Pro Phe Ala 420 425 430 cat att ctc tcg cca aaa aat caa gaa aaa tat aga tta gac tca tcg 1344 His Ile Leu Ser Pro Lys Asn Gln Glu Lys Tyr Arg Leu Asp Ser Ser 435 440 445 aaa aat gga aac gac acc ata agt aat ccc ctc gag agt tca tgc ata 1392 Lys Asn Gly Asn Asp Thr Ile Ser Asn Pro Leu Glu Ser Ser Cys Ile 450 455 460 agc tca gat gca caa gat gag gag agg aaa tcc gta acg gaa aca gaa 1440 Ser Ser Asp Ala Gln Asp Glu Glu Arg Lys Ser Val Thr Glu Thr Glu 465 470 475 480 aca gaa ata gtt gtt gaa cgg act cgt cag gct cat ttt gca atc taa 1488 Thr Glu Ile Val Val Glu Arg Thr Arg Gln Ala His Phe Ala Ile 485 490 495 <210> 57 <211> 495 <212> PRT <213> Saccharomyces cerevisiae <400> 57 Met Lys Thr Asp Arg Leu Leu Ile Asn Ala Ser Pro Glu Thr Cys Thr 1 5 10 15 Lys Gly Asp Ala Glu Met Asp Thr Met Asp Thr Ile Asp Arg Met Thr Page 88 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 Ser Val Lys Val Leu Ala Glu Gly Lys Val Leu Ser Asn Phe Glu Glu 35 40 45 Pro Gly Leu Met Arg Cys Gly Tyr His Asp Ala Lys Asn Trp Val Arg 50 55 60 Arg Leu Ser Ser Glu Thr Ile Val Gly Glu Asp Thr Ser Asn Leu Tyr 65 70 75 80 Pro Phe Tyr Val Asp Thr Ala Tyr Asp Val Arg Arg Leu Arg Lys Asp 85 90 95 Leu Ile Asn Ala Lys Val Asp Leu Gln Val Glu Asn Leu Ile Ile Ile 100 105 110 Cys Asn Ile Asn Asp Ile Ser Thr Val Phe Leu Met Arg Glu Val Val 115 120 125 Glu Trp Ile Leu Arg Asn Phe His Ser Ile Thr Val Tyr Val Gln Asp 130 135 140 Ile Phe Lys Lys Ser Thr Gln Phe Ala Val Gly Asp Leu Cys Lys Asp 145 150 155 160 Ser Asn Cys Ser Lys Asn Arg Val Lys Tyr Trp Ser Lys Glu Phe Val 165 170 175 Lys Lys His Asp Ser Phe Phe Asp Leu Met Ile Thr Leu Gly Gly Asp 180 185 190 Gly Thr Val Leu Phe Ala Ser Ser Ile Phe Thr Lys Asp Val Pro Pro 195 200 205 Ile Val Pro Phe Ala Leu Gly Ser Leu Gly Phe Leu Thr Asn Phe Glu 210 215 220 Phe Gln Asn Phe Lys Glu Thr Leu Lys His Ile Leu Thr Asp Glu Val 225 230 235 240 Arg Ile Asn Leu Arg Met Arg Leu Gln Cys Lys Leu Tyr Arg Arg Asn 245 250 255 Lys Pro Glu Ile Asp Ala Ala Thr Gly Arg Lys Ile Cys Tyr Ile Asp 260 265 270 Phe Ile Ser Glu His His Val Leu Asn Glu Val Thr Ile Asp Arg Gly 275 280 285 Pro Ala Pro Cys Leu Ser Leu Leu Glu Leu Tyr Gly Asn Asp Ser Leu Page 89 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 290 295 300 Met Thr Lys Val Gln Gly Asp Gly Leu Ile Val Ala Thr Pro Thr Gly 305 310 315 320 Ser Thr Ala Tyr Ser Leu Ser Ala Gly Gly Ser Leu Ile Ser Pro Ser 325 330 335 Val Asn Ala Ile Ala Val Thr Pro Ile Cys Pro His Thr Leu Ser Phe 340 345 350 Arg Pro Ile Ile Leu Pro Asp Ser Met Glu Leu Lys Val Arg Val Asp 355 360 365 Met Asn Ser Arg Gly Thr Ser Trp Val Asn Phe Asp Gly Lys Asp Arg 370 375 380 Val Glu Leu Lys Gln Gly Asp Tyr Val Val Ile Thr Ala Ser Pro Tyr 385 390 395 400 Ser Val Pro Thr Ile Glu Ser Ser Ala Ser Glu Phe Phe Glu Ser Ile 405 410 415 Ser Lys Asn Leu Asn Trp Asn Asp Arg Glu Glu Gln Lys Pro Phe Ala 420 425 430 His Ile Leu Ser Pro Lys Asn Gln Glu Lys Tyr Arg Leu Asp Ser Ser 435 440 445 Lys Asn Gly Asn Asp Thr Ile Ser Asn Pro Leu Glu Ser Ser Cys Ile 450 455 460 Ser Ser Asp Ala Gln Asp Glu Glu Arg Lys Ser Val Thr Glu Thr Glu 465 470 475 480 Thr Glu Ile Val Val Glu Arg Thr Arg Gln Ala His Phe Ala Ile 485 490 495 <210> 58 <211> 1125 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1125) <400> 58 atg agg ata cag tcg ctt ttt gtt tta ttt aat gtt gcc atc atc gca 48 Met Arg Ile Gln Ser Leu Phe Val Leu Phe Asn Val Ala Ile Ile Ala 1 5 10 15 tgg tca tat cca tat gag cct tta agg gtt tta caa gta gga gag aat 96 Page 90 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Trp Ser Tyr Pro Tyr Glu Pro Leu Arg Val Leu Gln Val Gly Glu Asn 20 25 30 gag gta atg gag gtt ccc gaa tca gaa aag cta aac tta cga aga aga 144 Glu Val Met Glu Val Pro Glu Ser Glu Lys Leu Asn Leu Arg Arg Arg 35 40 45 ggt gtc aaa ttc ttt gat gtg acc aaa cac act tct ttc tta cct ttc 192 Gly Val Lys Phe Phe Asp Val Thr Lys His Thr Ser Phe Leu Pro Phe 50 55 60 ttt aac aag gag gaa gag cca aca gta cca acg tat aac tat cct cct 240 Phe Asn Lys Glu Glu Glu Pro Thr Val Pro Thr Tyr Asn Tyr Pro Pro 65 70 75 80 gag ata tcg aac aaa gaa gta gtg gat gat tcg att aag aat ata gac 288 Glu Ile Ser Asn Lys Glu Val Val Asp Asp Ser Ile Lys Asn Ile Asp 85 90 95 aag ggc tct atg cac aag aac ttg gca aag ttt aca agt ttt tac acc 336 Lys Gly Ser Met His Lys Asn Leu Ala Lys Phe Thr Ser Phe Tyr Thr 100 105 110 cgt tac tac aag tcc gat cac ggc ttt gaa tct gcc gag tgg tta gct 384 Arg Tyr Tyr Lys Ser Asp His Gly Phe Glu Ser Ala Glu Trp Leu Ala 115 120 125 gca act atc gct aat att aca aaa gat att ccg caa gat acg ttg act 432 Ala Thr Ile Ala Asn Ile Thr Lys Asp Ile Pro Gln Asp Thr Leu Thr 130 135 140 att gaa cat ttt gat cac aaa gaa tgg aag caa tat tca att ata gtc 480 Ile Glu His Phe Asp His Lys Glu Trp Lys Gln Tyr Ser Ile Ile Val 145 150 155 160 cgt gtc acg gga tct act acg cca gaa gat att ata ata att ggt tct 528 Arg Val Thr Gly Ser Thr Thr Pro Glu Asp Ile Ile Ile Ile Gly Ser 165 170 175 cat caa gat tct atc aat ctg cta ctg cca tcc ata atg gca gct cca 576 His Gln Asp Ser Ile Asn Leu Leu Leu Pro Ser Ile Met Ala Ala Pro 180 185 190 ggt gcg gac gac aat ggg tca ggc acg gtg act aat atg gag gct ctc 624 Gly Ala Asp Asp Asn Gly Ser Gly Thr Val Thr Asn Met Glu Ala Leu 195 200 205 aga tta tat acg gaa aat ttt ttg aag aga gga ttt aga cct aac aac 672 Arg Leu Tyr Thr Glu Asn Phe Leu Lys Arg Gly Phe Arg Pro Asn Asn 210 215 220 act gtg gaa ttt cac ttt tat tcc gcc gaa gag ggg gga ttg ttg ggt 720 Thr Val Glu Phe His Phe Tyr Ser Ala Glu Glu Gly Gly Leu Leu Gly 225 230 235 240 tct ctt gat gtt ttt aca gct tat gcc aaa cag aaa aag cat gtg aga 768 Ser Leu Asp Val Phe Thr Ala Tyr Ala Lys Gln Lys Lys His Val Arg 245 250 255 gcg atg ctt cag caa gac atg acg gga tat gtt tct gat cca gaa gat 816 Ala Met Leu Gln Gln Asp Met Thr Gly Tyr Val Ser Asp Pro Glu Asp 260 265 270 gaa cat gtg ggg att gtc acc gac tac act act ccc gca tta act gat 864 Glu His Val Gly Ile Val Thr Asp Tyr Thr Thr Pro Ala Leu Thr Asp 275 280 285 ttt ata aaa cta att atc aac tct tat cta tcc att cct tac agg gat 912 Page 91 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Ile Lys Leu Ile Ile Asn Ser Tyr Leu Ser Ile Pro Tyr Arg Asp 290 295 300 aca caa tgt ggc tat gct tgt agc gat cat ggg agt gcc acc aga aac 960 Thr Gln Cys Gly Tyr Ala Cys Ser Asp His Gly Ser Ala Thr Arg Asn 305 310 315 320 gga ttt cca ggc tcc ttc gtg att gaa agt gag ttc aaa aag act aac 1008 Gly Phe Pro Gly Ser Phe Val Ile Glu Ser Glu Phe Lys Lys Thr Asn 325 330 335 aag tat att cac agc acc atg gat act ttg gac aga tta agt ctc gct 1056 Lys Tyr Ile His Ser Thr Met Asp Thr Leu Asp Arg Leu Ser Leu Ala 340 345 350 cat atg gcg gaa cac aca aaa att gta tta ggg gta atc att gaa ctc 1104 His Met Ala Glu His Thr Lys Ile Val Leu Gly Val Ile Ile Glu Leu 355 360 365 ggg tca tgg tcc gct tgg taa 1125 Gly Ser Trp Ser Ala Trp 370 <210> 59 <211> 374 <212> PRT <213> Saccharomyces cerevisiae <400> 59 Met Arg Ile Gln Ser Leu Phe Val Leu Phe Asn Val Ala Ile Ile Ala 1 5 10 15 Trp Ser Tyr Pro Tyr Glu Pro Leu Arg Val Leu Gln Val Gly Glu Asn 20 25 30 Glu Val Met Glu Val Pro Glu Ser Glu Lys Leu Asn Leu Arg Arg Arg 35 40 45 Gly Val Lys Phe Phe Asp Val Thr Lys His Thr Ser Phe Leu Pro Phe 50 55 60 Phe Asn Lys Glu Glu Glu Pro Thr Val Pro Thr Tyr Asn Tyr Pro Pro 65 70 75 80 Glu Ile Ser Asn Lys Glu Val Val Asp Asp Ser Ile Lys Asn Ile Asp 85 90 95 Lys Gly Ser Met His Lys Asn Leu Ala Lys Phe Thr Ser Phe Tyr Thr 100 105 110 Arg Tyr Tyr Lys Ser Asp His Gly Phe Glu Ser Ala Glu Trp Leu Ala 115 120 125 Ala Thr Ile Ala Asn Ile Thr Lys Asp Ile Pro Gln Asp Thr Leu Thr 130 135 140 Ile Glu His Phe Asp His Lys Glu Trp Lys Gln Tyr Ser Ile Ile Val Page 92 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 Arg Val Thr Gly Ser Thr Thr Pro Glu Asp Ile Ile Ile Ile Gly Ser 165 170 175 His Gln Asp Ser Ile Asn Leu Leu Leu Pro Ser Ile Met Ala Ala Pro 180 185 190 Gly Ala Asp Asp Asn Gly Ser Gly Thr Val Thr Asn Met Glu Ala Leu 195 200 205 Arg Leu Tyr Thr Glu Asn Phe Leu Lys Arg Gly Phe Arg Pro Asn Asn 210 215 220 Thr Val Glu Phe His Phe Tyr Ser Ala Glu Glu Gly Gly Leu Leu Gly 225 230 235 240 Ser Leu Asp Val Phe Thr Ala Tyr Ala Lys Gln Lys Lys His Val Arg 245 250 255 Ala Met Leu Gln Gln Asp Met Thr Gly Tyr Val Ser Asp Pro Glu Asp 260 265 270 Glu His Val Gly Ile Val Thr Asp Tyr Thr Thr Pro Ala Leu Thr Asp 275 280 285 Phe Ile Lys Leu Ile Ile Asn Ser Tyr Leu Ser Ile Pro Tyr Arg Asp 290 295 300 Thr Gln Cys Gly Tyr Ala Cys Ser Asp His Gly Ser Ala Thr Arg Asn 305 310 315 320 Gly Phe Pro Gly Ser Phe Val Ile Glu Ser Glu Phe Lys Lys Thr Asn 325 330 335 Lys Tyr Ile His Ser Thr Met Asp Thr Leu Asp Arg Leu Ser Leu Ala 340 345 350 His Met Ala Glu His Thr Lys Ile Val Leu Gly Val Ile Ile Glu Leu 355 360 365 Gly Ser Trp Ser Ala Trp 370 <210> 60 <211> 1470 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS Page 93 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(1470) <400> 60 atg aca aaa agt gat tta tta ttt gat aaa ttc aac gac aaa cat gga 48 Met Thr Lys Ser Asp Leu Leu Phe Asp Lys Phe Asn Asp Lys His Gly 1 5 10 15 aag ttt cta gtt ttt ttt ggt acc ttt gta gat acc cct aaa tta gga 96 Lys Phe Leu Val Phe Phe Gly Thr Phe Val Asp Thr Pro Lys Leu Gly 20 25 30 gag ctg aga atc aga gag aaa aca tct gtt gga gtt ctc aac gga atc 144 Glu Leu Arg Ile Arg Glu Lys Thr Ser Val Gly Val Leu Asn Gly Ile 35 40 45 atc agg ttt gtg aac aga aat tca ctc gat cct gtc aaa gat tgt tta 192 Ile Arg Phe Val Asn Arg Asn Ser Leu Asp Pro Val Lys Asp Cys Leu 50 55 60 gat cac gat agt agc tta tca cca gag gat gtc acg gtg gtt gac ata 240 Asp His Asp Ser Ser Leu Ser Pro Glu Asp Val Thr Val Val Asp Ile 65 70 75 80 att gga aaa gac aag act cga aat aac agc ttt tat ttt cca ggt ttt 288 Ile Gly Lys Asp Lys Thr Arg Asn Asn Ser Phe Tyr Phe Pro Gly Phe 85 90 95 gtt gac acg cat aac cat gtc tcg caa tat cca aat gtc ggc gta ttt 336 Val Asp Thr His Asn His Val Ser Gln Tyr Pro Asn Val Gly Val Phe 100 105 110 ggg aat tct acc ctg ctg gat tgg cta gag aag tat acc ttc ccc ata 384 Gly Asn Ser Thr Leu Leu Asp Trp Leu Glu Lys Tyr Thr Phe Pro Ile 115 120 125 gaa gcc gca cta gca aac gaa aat att gcg aga gaa gtt tac aat aag 432 Glu Ala Ala Leu Ala Asn Glu Asn Ile Ala Arg Glu Val Tyr Asn Lys 130 135 140 gta ata agt aag acg ctt tct cac ggt aca acg act gtg gct tac tat 480 Val Ile Ser Lys Thr Leu Ser His Gly Thr Thr Thr Val Ala Tyr Tyr 145 150 155 160 aat acc att gat ctc aag tcc act aag ctc ttg gct caa cta agc tcc 528 Asn Thr Ile Asp Leu Lys Ser Thr Lys Leu Leu Ala Gln Leu Ser Ser 165 170 175 tta ttg ggg cag cgt gtt ctt gtt gga aaa gtg tgc atg gat acc aat 576 Leu Leu Gly Gln Arg Val Leu Val Gly Lys Val Cys Met Asp Thr Asn 180 185 190 ggt ccc gag tat tat att gaa gat act aaa act tcc ttt gaa agc act 624 Gly Pro Glu Tyr Tyr Ile Glu Asp Thr Lys Thr Ser Phe Glu Ser Thr 195 200 205 gtg aaa gtt gtt aag tac ata cgg gaa acc att tgt gat ccc ctc gta 672 Val Lys Val Val Lys Tyr Ile Arg Glu Thr Ile Cys Asp Pro Leu Val 210 215 220 aat cct ata gtg aca cca agg ttc gcg ccc tct tgt tct aga gaa cta 720 Asn Pro Ile Val Thr Pro Arg Phe Ala Pro Ser Cys Ser Arg Glu Leu 225 230 235 240 atg caa cag ttg tcc aag cta gtc aag gat gaa aac ata cac gtt caa 768 Met Gln Gln Leu Ser Lys Leu Val Lys Asp Glu Asn Ile His Val Gln 245 250 255 acc cac ttg tcg gaa aat aag gag gag ata cag tgg gtt caa gat tta 816 Page 94 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr His Leu Ser Glu Asn Lys Glu Glu Ile Gln Trp Val Gln Asp Leu 260 265 270 ttt ccc gaa tgt gag agc tat act gat gta tac gac aaa tat ggg ctg 864 Phe Pro Glu Cys Glu Ser Tyr Thr Asp Val Tyr Asp Lys Tyr Gly Leu 275 280 285 ctc aca gaa aaa aca gta ttg gca cat tgt att cat cta aca gat gcc 912 Leu Thr Glu Lys Thr Val Leu Ala His Cys Ile His Leu Thr Asp Ala 290 295 300 gaa gcg cgt gtg att aaa cag cgt cgc tgt ggt ata tct cat tgt ccc 960 Glu Ala Arg Val Ile Lys Gln Arg Arg Cys Gly Ile Ser His Cys Pro 305 310 315 320 att tcc aac tcc tct ctg act tct gga gag tgt agg gtt cga tgg ttg 1008 Ile Ser Asn Ser Ser Leu Thr Ser Gly Glu Cys Arg Val Arg Trp Leu 325 330 335 ctg gac cag ggc ata aag gtt ggt cta ggc acc gac gtt tca gcc ggt 1056 Leu Asp Gln Gly Ile Lys Val Gly Leu Gly Thr Asp Val Ser Ala Gly 340 345 350 cat tct tgt agc ata ctc acc acc gga agg cag gcc ttt gca gtt tca 1104 His Ser Cys Ser Ile Leu Thr Thr Gly Arg Gln Ala Phe Ala Val Ser 355 360 365 agg cat ttg gca atg aga gaa act gat cat gca aaa ctt tca gtc tcc 1152 Arg His Leu Ala Met Arg Glu Thr Asp His Ala Lys Leu Ser Val Ser 370 375 380 gag tgc cta ttt ctt gct aca atg ggc gga gca caa gtc ttg cgt atg 1200 Glu Cys Leu Phe Leu Ala Thr Met Gly Gly Ala Gln Val Leu Arg Met 385 390 395 400 gat gag acc ttg ggg act ttt gac gtc ggt aag cag ttt gac gct caa 1248 Asp Glu Thr Leu Gly Thr Phe Asp Val Gly Lys Gln Phe Asp Ala Gln 405 410 415 atg atc gat acc aat gct ccc ggc tca aac gtg gat atg ttt cat tgg 1296 Met Ile Asp Thr Asn Ala Pro Gly Ser Asn Val Asp Met Phe His Trp 420 425 430 cag cta aag gag aag gat caa atg caa gag caa gag caa gag caa ggg 1344 Gln Leu Lys Glu Lys Asp Gln Met Gln Glu Gln Glu Gln Glu Gln Gly 435 440 445 caa gac cct tat aag aac cca ccg ctg ctt act aat gaa gac ata atc 1392 Gln Asp Pro Tyr Lys Asn Pro Pro Leu Leu Thr Asn Glu Asp Ile Ile 450 455 460 gca aaa tgg ttc ttt aac ggt gat gat cgc aac acc act aaa gtt tgg 1440 Ala Lys Trp Phe Phe Asn Gly Asp Asp Arg Asn Thr Thr Lys Val Trp 465 470 475 480 gta gcc ggc cag caa gtc tac cag att tag 1470 Val Ala Gly Gln Gln Val Tyr Gln Ile 485 <210> 61 <211> 489 <212> PRT <213> Saccharomyces cerevisiae <400> 61 Met Thr Lys Ser Asp Leu Leu Phe Asp Lys Phe Asn Asp Lys His Gly Page 95 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 Lys Phe Leu Val Phe Phe Gly Thr Phe Val Asp Thr Pro Lys Leu Gly 20 25 30 Glu Leu Arg Ile Arg Glu Lys Thr Ser Val Gly Val Leu Asn Gly Ile 35 40 45 Ile Arg Phe Val Asn Arg Asn Ser Leu Asp Pro Val Lys Asp Cys Leu 50 55 60 Asp His Asp Ser Ser Leu Ser Pro Glu Asp Val Thr Val Val Asp Ile 65 70 75 80 Ile Gly Lys Asp Lys Thr Arg Asn Asn Ser Phe Tyr Phe Pro Gly Phe 85 90 95 Val Asp Thr His Asn His Val Ser Gln Tyr Pro Asn Val Gly Val Phe 100 105 110 Gly Asn Ser Thr Leu Leu Asp Trp Leu Glu Lys Tyr Thr Phe Pro Ile 115 120 125 Glu Ala Ala Leu Ala Asn Glu Asn Ile Ala Arg Glu Val Tyr Asn Lys 130 135 140 Val Ile Ser Lys Thr Leu Ser His Gly Thr Thr Thr Val Ala Tyr Tyr 145 150 155 160 Asn Thr Ile Asp Leu Lys Ser Thr Lys Leu Leu Ala Gln Leu Ser Ser 165 170 175 Leu Leu Gly Gln Arg Val Leu Val Gly Lys Val Cys Met Asp Thr Asn 180 185 190 Gly Pro Glu Tyr Tyr Ile Glu Asp Thr Lys Thr Ser Phe Glu Ser Thr 195 200 205 Val Lys Val Val Lys Tyr Ile Arg Glu Thr Ile Cys Asp Pro Leu Val 210 215 220 Asn Pro Ile Val Thr Pro Arg Phe Ala Pro Ser Cys Ser Arg Glu Leu 225 230 235 240 Met Gln Gln Leu Ser Lys Leu Val Lys Asp Glu Asn Ile His Val Gln 245 250 255 Thr His Leu Ser Glu Asn Lys Glu Glu Ile Gln Trp Val Gln Asp Leu 260 265 270 Page 96 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Pro Glu Cys Glu Ser Tyr Thr Asp Val Tyr Asp Lys Tyr Gly Leu 275 280 285 Leu Thr Glu Lys Thr Val Leu Ala His Cys Ile His Leu Thr Asp Ala 290 295 300 Glu Ala Arg Val Ile Lys Gln Arg Arg Cys Gly Ile Ser His Cys Pro 305 310 315 320 Ile Ser Asn Ser Ser Leu Thr Ser Gly Glu Cys Arg Val Arg Trp Leu 325 330 335 Leu Asp Gln Gly Ile Lys Val Gly Leu Gly Thr Asp Val Ser Ala Gly 340 345 350 His Ser Cys Ser Ile Leu Thr Thr Gly Arg Gln Ala Phe Ala Val Ser 355 360 365 Arg His Leu Ala Met Arg Glu Thr Asp His Ala Lys Leu Ser Val Ser 370 375 380 Glu Cys Leu Phe Leu Ala Thr Met Gly Gly Ala Gln Val Leu Arg Met 385 390 395 400 Asp Glu Thr Leu Gly Thr Phe Asp Val Gly Lys Gln Phe Asp Ala Gln 405 410 415 Met Ile Asp Thr Asn Ala Pro Gly Ser Asn Val Asp Met Phe His Trp 420 425 430 Gln Leu Lys Glu Lys Asp Gln Met Gln Glu Gln Glu Gln Glu Gln Gly 435 440 445 Gln Asp Pro Tyr Lys Asn Pro Pro Leu Leu Thr Asn Glu Asp Ile Ile 450 455 460 Ala Lys Trp Phe Phe Asn Gly Asp Asp Arg Asn Thr Thr Lys Val Trp 465 470 475 480 Val Ala Gly Gln Gln Val Tyr Gln Ile 485 <210> 62 <211> 441 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(441) <400> 62 atg aaa ggc tca ccc att tct caa ttt agt aag acc tct att aat gct 48 Page 97 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Lys Gly Ser Pro Ile Ser Gln Phe Ser Lys Thr Ser Ile Asn Ala 1 5 10 15 ctt acc agg cct tgg aag aaa tac aga gat ggt gaa tta ttt tat ggg 96 Leu Thr Arg Pro Trp Lys Lys Tyr Arg Asp Gly Glu Leu Phe Tyr Gly 20 25 30 tta tca aaa gtt ggg aat aaa aga gtg ccg ttg acc acg aag caa ggt 144 Leu Ser Lys Val Gly Asn Lys Arg Val Pro Leu Thr Thr Lys Gln Gly 35 40 45 aac aag acg atg tac aaa ggg aca aga gct tca ggg att ggt aga cat 192 Asn Lys Thr Met Tyr Lys Gly Thr Arg Ala Ser Gly Ile Gly Arg His 50 55 60 aca aaa ttc ggt ggt tat gtg ata aac tgg aag aaa gtc aga acc tat 240 Thr Lys Phe Gly Gly Tyr Val Ile Asn Trp Lys Lys Val Arg Thr Tyr 65 70 75 80 gtt acc cca gat atg gtt aat ttc gaa tta aag ccc tac gtt aac gca 288 Val Thr Pro Asp Met Val Asn Phe Glu Leu Lys Pro Tyr Val Asn Ala 85 90 95 aat gta cca cct cta aaa cac gaa ttt aaa gga ttt agc ggc ggc cca 336 Asn Val Pro Pro Leu Lys His Glu Phe Lys Gly Phe Ser Gly Gly Pro 100 105 110 tta gat cct cgt tta cag tta tta aag ata aaa gaa tac ata gta aac 384 Leu Asp Pro Arg Leu Gln Leu Leu Lys Ile Lys Glu Tyr Ile Val Asn 115 120 125 ggg agg gta caa agc gaa ggg gcc acc gac act tca tgt tat aag gag 432 Gly Arg Val Gln Ser Glu Gly Ala Thr Asp Thr Ser Cys Tyr Lys Glu 130 135 140 cgt gga taa 441 Arg Gly 145 <210> 63 <211> 146 <212> PRT <213> Saccharomyces cerevisiae <400> 63 Met Lys Gly Ser Pro Ile Ser Gln Phe Ser Lys Thr Ser Ile Asn Ala 1 5 10 15 Leu Thr Arg Pro Trp Lys Lys Tyr Arg Asp Gly Glu Leu Phe Tyr Gly 20 25 30 Leu Ser Lys Val Gly Asn Lys Arg Val Pro Leu Thr Thr Lys Gln Gly 35 40 45 Asn Lys Thr Met Tyr Lys Gly Thr Arg Ala Ser Gly Ile Gly Arg His 50 55 60 Thr Lys Phe Gly Gly Tyr Val Ile Asn Trp Lys Lys Val Arg Thr Tyr 65 70 75 80 Val Thr Pro Asp Met Val Asn Phe Glu Leu Lys Pro Tyr Val Asn Ala Page 98 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Asn Val Pro Pro Leu Lys His Glu Phe Lys Gly Phe Ser Gly Gly Pro 100 105 110 Leu Asp Pro Arg Leu Gln Leu Leu Lys Ile Lys Glu Tyr Ile Val Asn 115 120 125 Gly Arg Val Gln Ser Glu Gly Ala Thr Asp Thr Ser Cys Tyr Lys Glu 130 135 140 Arg Gly 145 <210> 64 <211> 429 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(429) <400> 64 atg gcg tat aat caa gaa gat agt aaa aga cta tca gac aag tat aag 48 Met Ala Tyr Asn Gln Glu Asp Ser Lys Arg Leu Ser Asp Lys Tyr Lys 1 5 10 15 aag gag gga cat ttt gac aag ttg aaa aga gaa ata ttg tct aac cca 96 Lys Glu Gly His Phe Asp Lys Leu Lys Arg Glu Ile Leu Ser Asn Pro 20 25 30 tgg aat aat aca gaa gag aat agt gaa tct ttt gaa caa gcg ctt cgg 144 Trp Asn Asn Thr Glu Glu Asn Ser Glu Ser Phe Glu Gln Ala Leu Arg 35 40 45 aaa aga gtt gcc agt act gtt aaa gaa atg gtt aac gaa gat gaa gaa 192 Lys Arg Val Ala Ser Thr Val Lys Glu Met Val Asn Glu Asp Glu Glu 50 55 60 tta ata ttt aaa aac aga ggg cta acc agt gca ttg att gaa tca caa 240 Leu Ile Phe Lys Asn Arg Gly Leu Thr Ser Ala Leu Ile Glu Ser Gln 65 70 75 80 ttg gtc aag gac aac tac cta aag ctg ggt agt aaa atg gag ggg gat 288 Leu Val Lys Asp Asn Tyr Leu Lys Leu Gly Ser Lys Met Glu Gly Asp 85 90 95 aat ggt gat ggt gag aag aaa ttt gac ttg gat gtc tat gta cgg tct 336 Asn Gly Asp Gly Glu Lys Lys Phe Asp Leu Asp Val Tyr Val Arg Ser 100 105 110 aag tta cag gat ccc aaa cta ttg gaa atg ata aag gga caa ctt cag 384 Lys Leu Gln Asp Pro Lys Leu Leu Glu Met Ile Lys Gly Gln Leu Gln 115 120 125 gaa aca ctg aac tct tat gaa gag gaa gca aat gga agt acg taa 429 Glu Thr Leu Asn Ser Tyr Glu Glu Glu Ala Asn Gly Ser Thr 130 135 140 <210> 65 Page 99 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 142 <212> PRT <213> Saccharomyces cerevisiae <400> 65 Met Ala Tyr Asn Gln Glu Asp Ser Lys Arg Leu Ser Asp Lys Tyr Lys 1 5 10 15 Lys Glu Gly His Phe Asp Lys Leu Lys Arg Glu Ile Leu Ser Asn Pro 20 25 30 Trp Asn Asn Thr Glu Glu Asn Ser Glu Ser Phe Glu Gln Ala Leu Arg 35 40 45 Lys Arg Val Ala Ser Thr Val Lys Glu Met Val Asn Glu Asp Glu Glu 50 55 60 Leu Ile Phe Lys Asn Arg Gly Leu Thr Ser Ala Leu Ile Glu Ser Gln 65 70 75 80 Leu Val Lys Asp Asn Tyr Leu Lys Leu Gly Ser Lys Met Glu Gly Asp 85 90 95 Asn Gly Asp Gly Glu Lys Lys Phe Asp Leu Asp Val Tyr Val Arg Ser 100 105 110 Lys Leu Gln Asp Pro Lys Leu Leu Glu Met Ile Lys Gly Gln Leu Gln 115 120 125 Glu Thr Leu Asn Ser Tyr Glu Glu Glu Ala Asn Gly Ser Thr 130 135 140 <210> 66 <211> 462 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(462) <400> 66 atg acc ttt tta caa ttt atc aat aat aat aga caa gaa gga caa ggt 48 Met Thr Phe Leu Gln Phe Ile Asn Asn Asn Arg Gln Glu Gly Gln Gly 1 5 10 15 tat att tca gaa aaa tta ttc aaa act aag aag aat gag atg ata aga 96 Tyr Ile Ser Glu Lys Leu Phe Lys Thr Lys Lys Asn Glu Met Ile Arg 20 25 30 aaa aca gtt acc aat tta gta gct gta aga tta aaa aac tta tcc cac 144 Lys Thr Val Thr Asn Leu Val Ala Val Arg Leu Lys Asn Leu Ser His 35 40 45 gaa ttt gat gta ata gag aat tat ctg cgc tat ata gct agc acc agt 192 Glu Phe Asp Val Ile Glu Asn Tyr Leu Arg Tyr Ile Ala Ser Thr Ser 50 55 60 Page 100 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa cat cta ttt act gct att aag cgc cac ttt aac aaa tgt gcc aga 240 Glu His Leu Phe Thr Ala Ile Lys Arg His Phe Asn Lys Cys Ala Arg 65 70 75 80 aaa ctt ttg aaa gaa gca atc gac tcc aaa tca aac tca gaa act gct 288 Lys Leu Leu Lys Glu Ala Ile Asp Ser Lys Ser Asn Ser Glu Thr Ala 85 90 95 acg gtg gtt ctg caa gaa gga ttt tct ggc att tgc tta ttg aaa gcg 336 Thr Val Val Leu Gln Glu Gly Phe Ser Gly Ile Cys Leu Leu Lys Ala 100 105 110 tct tca att ata tta aaa cta aaa ttg aag ttt cca aaa aag aaa gat 384 Ser Ser Ile Ile Leu Lys Leu Lys Leu Lys Phe Pro Lys Lys Lys Asp 115 120 125 aga act gat att agc aaa ttg tgt gac aag aaa gaa cgg atg aca cag 432 Arg Thr Asp Ile Ser Lys Leu Cys Asp Lys Lys Glu Arg Met Thr Gln 130 135 140 tgg tta gaa att tca att ttg atg aac tga 462 Trp Leu Glu Ile Ser Ile Leu Met Asn 145 150 <210> 67 <211> 153 <212> PRT <213> Saccharomyces cerevisiae <400> 67 Met Thr Phe Leu Gln Phe Ile Asn Asn Asn Arg Gln Glu Gly Gln Gly 1 5 10 15 Tyr Ile Ser Glu Lys Leu Phe Lys Thr Lys Lys Asn Glu Met Ile Arg 20 25 30 Lys Thr Val Thr Asn Leu Val Ala Val Arg Leu Lys Asn Leu Ser His 35 40 45 Glu Phe Asp Val Ile Glu Asn Tyr Leu Arg Tyr Ile Ala Ser Thr Ser 50 55 60 Glu His Leu Phe Thr Ala Ile Lys Arg His Phe Asn Lys Cys Ala Arg 65 70 75 80 Lys Leu Leu Lys Glu Ala Ile Asp Ser Lys Ser Asn Ser Glu Thr Ala 85 90 95 Thr Val Val Leu Gln Glu Gly Phe Ser Gly Ile Cys Leu Leu Lys Ala 100 105 110 Ser Ser Ile Ile Leu Lys Leu Lys Leu Lys Phe Pro Lys Lys Lys Asp 115 120 125 Arg Thr Asp Ile Ser Lys Leu Cys Asp Lys Lys Glu Arg Met Thr Gln 130 135 140 Page 101 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Trp Leu Glu Ile Ser Ile Leu Met Asn 145 150 <210> 68 <211> 1584 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1584) <400> 68 atg agt ctc tcg cag gtg tca cct tta ccc cat atc aag gat gtt gtt 48 Met Ser Leu Ser Gln Val Ser Pro Leu Pro His Ile Lys Asp Val Val 1 5 10 15 tta gga gat aca gta ggc caa ggc gca ttc gcc tgc gtt aaa aat gct 96 Leu Gly Asp Thr Val Gly Gln Gly Ala Phe Ala Cys Val Lys Asn Ala 20 25 30 cat ctt caa atg gat ccc tcc att att cta gct gtt aaa ttc att cat 144 His Leu Gln Met Asp Pro Ser Ile Ile Leu Ala Val Lys Phe Ile His 35 40 45 gtt ccc act tgc aaa aaa atg gga ctc agt gac aag gat atc aca aaa 192 Val Pro Thr Cys Lys Lys Met Gly Leu Ser Asp Lys Asp Ile Thr Lys 50 55 60 gag gtt gtt ttg caa tcg aag tgt tct aag cat cct aat gtt ttg aga 240 Glu Val Val Leu Gln Ser Lys Cys Ser Lys His Pro Asn Val Leu Arg 65 70 75 80 ctt atc gat tgt aat gtc tct aaa gaa tat atg tgg ata att ctg gag 288 Leu Ile Asp Cys Asn Val Ser Lys Glu Tyr Met Trp Ile Ile Leu Glu 85 90 95 atg gca gat ggt ggt gat cta ttt gat aag att gag cct gac gtt gga 336 Met Ala Asp Gly Gly Asp Leu Phe Asp Lys Ile Glu Pro Asp Val Gly 100 105 110 gtt gat tcc gac gtg gcc caa ttt tac ttt caa cag ctc gtt agt gct 384 Val Asp Ser Asp Val Ala Gln Phe Tyr Phe Gln Gln Leu Val Ser Ala 115 120 125 att aat tat ctg cat gta gaa tgt gga gtt gct cac aga gac atc aag 432 Ile Asn Tyr Leu His Val Glu Cys Gly Val Ala His Arg Asp Ile Lys 130 135 140 cct gaa aac atc tta ctc gat aag aac gga aat ctg aag cta gct gat 480 Pro Glu Asn Ile Leu Leu Asp Lys Asn Gly Asn Leu Lys Leu Ala Asp 145 150 155 160 ttt ggg ctc gcc tct caa ttt agg agg aaa gat ggt aca tta cgt gta 528 Phe Gly Leu Ala Ser Gln Phe Arg Arg Lys Asp Gly Thr Leu Arg Val 165 170 175 tcc atg gat caa agg ggt tct cca ccc tac atg gct cct gaa gta tta 576 Ser Met Asp Gln Arg Gly Ser Pro Pro Tyr Met Ala Pro Glu Val Leu 180 185 190 tat tct gaa gag ggt tat tac gca gat cga aca gat ata tgg tct att 624 Tyr Ser Glu Glu Gly Tyr Tyr Ala Asp Arg Thr Asp Ile Trp Ser Ile 195 200 205 Page 102 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggc atc ctc ttg ttc gta ttg ttg act ggt caa acg cct tgg gaa tta 672 Gly Ile Leu Leu Phe Val Leu Leu Thr Gly Gln Thr Pro Trp Glu Leu 210 215 220 cct tca tta gag aac gaa gat ttc gtc ttt ttt att gaa aat gat gga 720 Pro Ser Leu Glu Asn Glu Asp Phe Val Phe Phe Ile Glu Asn Asp Gly 225 230 235 240 aat tta aac tgg gga ccc tgg tca aag ata gaa ttt act cac ttg aac 768 Asn Leu Asn Trp Gly Pro Trp Ser Lys Ile Glu Phe Thr His Leu Asn 245 250 255 cta ctc cga aaa att tta caa cct gac cca aat aag agg gtg aca ttg 816 Leu Leu Arg Lys Ile Leu Gln Pro Asp Pro Asn Lys Arg Val Thr Leu 260 265 270 aag gct tta aag tta cat cct tgg gta tta cgt cga gct tca ttt tct 864 Lys Ala Leu Lys Leu His Pro Trp Val Leu Arg Arg Ala Ser Phe Ser 275 280 285 ggg gat gat ggt ctc tgt aat gac cct gaa ctc ttg gct aag aaa ctg 912 Gly Asp Asp Gly Leu Cys Asn Asp Pro Glu Leu Leu Ala Lys Lys Leu 290 295 300 ttt tct cac tta aaa gtc tca ctg agt aac gaa aat tat ttg aaa ttc 960 Phe Ser His Leu Lys Val Ser Leu Ser Asn Glu Asn Tyr Leu Lys Phe 305 310 315 320 act caa gat aca aac tct aat aat agg tac att tct act cag cca att 1008 Thr Gln Asp Thr Asn Ser Asn Asn Arg Tyr Ile Ser Thr Gln Pro Ile 325 330 335 ggt aac gaa ttg gct gag ctt gaa cac gac tca atg cat ttc cag aca 1056 Gly Asn Glu Leu Ala Glu Leu Glu His Asp Ser Met His Phe Gln Thr 340 345 350 gtt tcg aat aca caa cgt gca ttt acc tcg tat gat tca aat acg aac 1104 Val Ser Asn Thr Gln Arg Ala Phe Thr Ser Tyr Asp Ser Asn Thr Asn 355 360 365 tat aat agc gga aca ggt atg aca caa gag gct aag tgg acg caa ttc 1152 Tyr Asn Ser Gly Thr Gly Met Thr Gln Glu Ala Lys Trp Thr Gln Phe 370 375 380 ata agc tat gat atc gct gcc tta cag ttt cat tct gat gaa aat gat 1200 Ile Ser Tyr Asp Ile Ala Ala Leu Gln Phe His Ser Asp Glu Asn Asp 385 390 395 400 tgt aat gaa tta gta aaa cga cat tta caa ttt aat ccg aat aaa ctt 1248 Cys Asn Glu Leu Val Lys Arg His Leu Gln Phe Asn Pro Asn Lys Leu 405 410 415 acc aag ttc tac acg ttg caa cct atg gat gtt ttg tta ccg att ttg 1296 Thr Lys Phe Tyr Thr Leu Gln Pro Met Asp Val Leu Leu Pro Ile Leu 420 425 430 gag aaa gcc ttg aat tta tca caa att aga gta aaa ccc gac ctt ttt 1344 Glu Lys Ala Leu Asn Leu Ser Gln Ile Arg Val Lys Pro Asp Leu Phe 435 440 445 gcg aat ttt gaa aga ttg tgc gaa tta ttg ggt tat gat aac gtt ttc 1392 Ala Asn Phe Glu Arg Leu Cys Glu Leu Leu Gly Tyr Asp Asn Val Phe 450 455 460 cca ctt att ata aat att aaa acc aaa agt aat ggg ggt tat caa tta 1440 Pro Leu Ile Ile Asn Ile Lys Thr Lys Ser Asn Gly Gly Tyr Gln Leu 465 470 475 480 Page 103 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tgc ggt agc att tcc atc ata aag att gaa gaa gag ttg aaa agt gtc 1488 Cys Gly Ser Ile Ser Ile Ile Lys Ile Glu Glu Glu Leu Lys Ser Val 485 490 495 gga ttt gaa aga aaa act ggt gat cct tta gaa tgg aga aga ttg ttc 1536 Gly Phe Glu Arg Lys Thr Gly Asp Pro Leu Glu Trp Arg Arg Leu Phe 500 505 510 aag aaa att tca act atc tgt agg gat att atc cta att ccc aac tga 1584 Lys Lys Ile Ser Thr Ile Cys Arg Asp Ile Ile Leu Ile Pro Asn 515 520 525 <210> 69 <211> 527 <212> PRT <213> Saccharomyces cerevisiae <400> 69 Met Ser Leu Ser Gln Val Ser Pro Leu Pro His Ile Lys Asp Val Val 1 5 10 15 Leu Gly Asp Thr Val Gly Gln Gly Ala Phe Ala Cys Val Lys Asn Ala 20 25 30 His Leu Gln Met Asp Pro Ser Ile Ile Leu Ala Val Lys Phe Ile His 35 40 45 Val Pro Thr Cys Lys Lys Met Gly Leu Ser Asp Lys Asp Ile Thr Lys 50 55 60 Glu Val Val Leu Gln Ser Lys Cys Ser Lys His Pro Asn Val Leu Arg 65 70 75 80 Leu Ile Asp Cys Asn Val Ser Lys Glu Tyr Met Trp Ile Ile Leu Glu 85 90 95 Met Ala Asp Gly Gly Asp Leu Phe Asp Lys Ile Glu Pro Asp Val Gly 100 105 110 Val Asp Ser Asp Val Ala Gln Phe Tyr Phe Gln Gln Leu Val Ser Ala 115 120 125 Ile Asn Tyr Leu His Val Glu Cys Gly Val Ala His Arg Asp Ile Lys 130 135 140 Pro Glu Asn Ile Leu Leu Asp Lys Asn Gly Asn Leu Lys Leu Ala Asp 145 150 155 160 Phe Gly Leu Ala Ser Gln Phe Arg Arg Lys Asp Gly Thr Leu Arg Val 165 170 175 Ser Met Asp Gln Arg Gly Ser Pro Pro Tyr Met Ala Pro Glu Val Leu 180 185 190 Page 104 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Tyr Ser Glu Glu Gly Tyr Tyr Ala Asp Arg Thr Asp Ile Trp Ser Ile 195 200 205 Gly Ile Leu Leu Phe Val Leu Leu Thr Gly Gln Thr Pro Trp Glu Leu 210 215 220 Pro Ser Leu Glu Asn Glu Asp Phe Val Phe Phe Ile Glu Asn Asp Gly 225 230 235 240 Asn Leu Asn Trp Gly Pro Trp Ser Lys Ile Glu Phe Thr His Leu Asn 245 250 255 Leu Leu Arg Lys Ile Leu Gln Pro Asp Pro Asn Lys Arg Val Thr Leu 260 265 270 Lys Ala Leu Lys Leu His Pro Trp Val Leu Arg Arg Ala Ser Phe Ser 275 280 285 Gly Asp Asp Gly Leu Cys Asn Asp Pro Glu Leu Leu Ala Lys Lys Leu 290 295 300 Phe Ser His Leu Lys Val Ser Leu Ser Asn Glu Asn Tyr Leu Lys Phe 305 310 315 320 Thr Gln Asp Thr Asn Ser Asn Asn Arg Tyr Ile Ser Thr Gln Pro Ile 325 330 335 Gly Asn Glu Leu Ala Glu Leu Glu His Asp Ser Met His Phe Gln Thr 340 345 350 Val Ser Asn Thr Gln Arg Ala Phe Thr Ser Tyr Asp Ser Asn Thr Asn 355 360 365 Tyr Asn Ser Gly Thr Gly Met Thr Gln Glu Ala Lys Trp Thr Gln Phe 370 375 380 Ile Ser Tyr Asp Ile Ala Ala Leu Gln Phe His Ser Asp Glu Asn Asp 385 390 395 400 Cys Asn Glu Leu Val Lys Arg His Leu Gln Phe Asn Pro Asn Lys Leu 405 410 415 Thr Lys Phe Tyr Thr Leu Gln Pro Met Asp Val Leu Leu Pro Ile Leu 420 425 430 Glu Lys Ala Leu Asn Leu Ser Gln Ile Arg Val Lys Pro Asp Leu Phe 435 440 445 Ala Asn Phe Glu Arg Leu Cys Glu Leu Leu Gly Tyr Asp Asn Val Phe 450 455 460 Page 105 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Leu Ile Ile Asn Ile Lys Thr Lys Ser Asn Gly Gly Tyr Gln Leu 465 470 475 480 Cys Gly Ser Ile Ser Ile Ile Lys Ile Glu Glu Glu Leu Lys Ser Val 485 490 495 Gly Phe Glu Arg Lys Thr Gly Asp Pro Leu Glu Trp Arg Arg Leu Phe 500 505 510 Lys Lys Ile Ser Thr Ile Cys Arg Asp Ile Ile Leu Ile Pro Asn 515 520 525 <210> 70 <211> 849 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(849) <400> 70 atg gat cca agt tta gtt tta gag caa acg ata caa gat gtg tcc aac 48 Met Asp Pro Ser Leu Val Leu Glu Gln Thr Ile Gln Asp Val Ser Asn 1 5 10 15 ctc cca tca gaa ttt cgt tac ctc tta gag gag atc ggt tca aat gat 96 Leu Pro Ser Glu Phe Arg Tyr Leu Leu Glu Glu Ile Gly Ser Asn Asp 20 25 30 ttg aag ctc atc gaa gaa aaa aag aaa tac gag caa aaa gaa tca caa 144 Leu Lys Leu Ile Glu Glu Lys Lys Lys Tyr Glu Gln Lys Glu Ser Gln 35 40 45 ata cac aaa ttt ata aga cag caa ggc tca ata ccg aaa cat cca cag 192 Ile His Lys Phe Ile Arg Gln Gln Gly Ser Ile Pro Lys His Pro Gln 50 55 60 gaa gat ggg ctt gac aaa gaa ata aaa gaa tca ctt ttg aaa tgt cag 240 Glu Asp Gly Leu Asp Lys Glu Ile Lys Glu Ser Leu Leu Lys Cys Gln 65 70 75 80 tct ttg caa aga gaa aaa tgc gtt ctg gcg aac act gcc ttg ttt cta 288 Ser Leu Gln Arg Glu Lys Cys Val Leu Ala Asn Thr Ala Leu Phe Leu 85 90 95 att gct aga cac ttg aat aag ttg gaa aaa aac atc gct tta ttg gag 336 Ile Ala Arg His Leu Asn Lys Leu Glu Lys Asn Ile Ala Leu Leu Glu 100 105 110 gaa gat ggt gtt cta gcc ccc gtg gaa gaa gat gga gac atg gat agc 384 Glu Asp Gly Val Leu Ala Pro Val Glu Glu Asp Gly Asp Met Asp Ser 115 120 125 gct gct gaa gcc tct aga gaa agt tca gtt gtg agt aac agt agc gtg 432 Ala Ala Glu Ala Ser Arg Glu Ser Ser Val Val Ser Asn Ser Ser Val 130 135 140 aaa aag aga aga gct gca tca agc tca gga tcc gtt cca ccc act ttg 480 Lys Lys Arg Arg Ala Ala Ser Ser Ser Gly Ser Val Pro Pro Thr Leu 145 150 155 160 Page 106 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aaa aag aaa aaa act agt cga aca tct aaa ctg caa aat gaa att gac 528 Lys Lys Lys Lys Thr Ser Arg Thr Ser Lys Leu Gln Asn Glu Ile Asp 165 170 175 gtt tct tca aga gaa aag tct gtt act cca gtg agc cca agc att gaa 576 Val Ser Ser Arg Glu Lys Ser Val Thr Pro Val Ser Pro Ser Ile Glu 180 185 190 aag aag att gca aga aca aaa gaa ttc aaa aac agt aga aat ggt aaa 624 Lys Lys Ile Ala Arg Thr Lys Glu Phe Lys Asn Ser Arg Asn Gly Lys 195 200 205 ggc caa aac ggt tcc cct gaa aac gag gaa gag gac aaa act tta tac 672 Gly Gln Asn Gly Ser Pro Glu Asn Glu Glu Glu Asp Lys Thr Leu Tyr 210 215 220 tgc ttc tgt caa aga gtt tcg ttt gga gaa atg gtt gca tgt gat gga 720 Cys Phe Cys Gln Arg Val Ser Phe Gly Glu Met Val Ala Cys Asp Gly 225 230 235 240 ccc aac tgt aaa tat gaa tgg ttt cat tat gat tgt gta aat tta aaa 768 Pro Asn Cys Lys Tyr Glu Trp Phe His Tyr Asp Cys Val Asn Leu Lys 245 250 255 gaa cct ccg aaa gga aca tgg tac tgt ccc gaa tgt aaa att gag atg 816 Glu Pro Pro Lys Gly Thr Trp Tyr Cys Pro Glu Cys Lys Ile Glu Met 260 265 270 gaa aaa aac aaa ctg aaa aga aaa cgt aac tga 849 Glu Lys Asn Lys Leu Lys Arg Lys Arg Asn 275 280 <210> 71 <211> 282 <212> PRT <213> Saccharomyces cerevisiae <400> 71 Met Asp Pro Ser Leu Val Leu Glu Gln Thr Ile Gln Asp Val Ser Asn 1 5 10 15 Leu Pro Ser Glu Phe Arg Tyr Leu Leu Glu Glu Ile Gly Ser Asn Asp 20 25 30 Leu Lys Leu Ile Glu Glu Lys Lys Lys Tyr Glu Gln Lys Glu Ser Gln 35 40 45 Ile His Lys Phe Ile Arg Gln Gln Gly Ser Ile Pro Lys His Pro Gln 50 55 60 Glu Asp Gly Leu Asp Lys Glu Ile Lys Glu Ser Leu Leu Lys Cys Gln 65 70 75 80 Ser Leu Gln Arg Glu Lys Cys Val Leu Ala Asn Thr Ala Leu Phe Leu 85 90 95 Ile Ala Arg His Leu Asn Lys Leu Glu Lys Asn Ile Ala Leu Leu Glu 100 105 110 Page 107 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Asp Gly Val Leu Ala Pro Val Glu Glu Asp Gly Asp Met Asp Ser 115 120 125 Ala Ala Glu Ala Ser Arg Glu Ser Ser Val Val Ser Asn Ser Ser Val 130 135 140 Lys Lys Arg Arg Ala Ala Ser Ser Ser Gly Ser Val Pro Pro Thr Leu 145 150 155 160 Lys Lys Lys Lys Thr Ser Arg Thr Ser Lys Leu Gln Asn Glu Ile Asp 165 170 175 Val Ser Ser Arg Glu Lys Ser Val Thr Pro Val Ser Pro Ser Ile Glu 180 185 190 Lys Lys Ile Ala Arg Thr Lys Glu Phe Lys Asn Ser Arg Asn Gly Lys 195 200 205 Gly Gln Asn Gly Ser Pro Glu Asn Glu Glu Glu Asp Lys Thr Leu Tyr 210 215 220 Cys Phe Cys Gln Arg Val Ser Phe Gly Glu Met Val Ala Cys Asp Gly 225 230 235 240 Pro Asn Cys Lys Tyr Glu Trp Phe His Tyr Asp Cys Val Asn Leu Lys 245 250 255 Glu Pro Pro Lys Gly Thr Trp Tyr Cys Pro Glu Cys Lys Ile Glu Met 260 265 270 Glu Lys Asn Lys Leu Lys Arg Lys Arg Asn 275 280 <210> 72 <211> 1479 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1479) <400> 72 atg gag agt cga act aca ggg cct tta acg act gaa acc tac gat ggc 48 Met Glu Ser Arg Thr Thr Gly Pro Leu Thr Thr Glu Thr Tyr Asp Gly 1 5 10 15 ccc act gtg gcc ttc atg ata tta ggt gcc gcc cta gta ttt ttt atg 96 Pro Thr Val Ala Phe Met Ile Leu Gly Ala Ala Leu Val Phe Phe Met 20 25 30 gtg ccc gga ttg gga ttc ttg tac tcc gga ttg gca aga agg aag tct 144 Val Pro Gly Leu Gly Phe Leu Tyr Ser Gly Leu Ala Arg Arg Lys Ser 35 40 45 Page 108 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gca cta gca cta atc tgg gtt gta tta atg gcg act ttg gtc ggt ata 192 Ala Leu Ala Leu Ile Trp Val Val Leu Met Ala Thr Leu Val Gly Ile 50 55 60 ctg caa tgg tat ttc tgg ggt tac tct cta gct ttt tca aag tcc gct 240 Leu Gln Trp Tyr Phe Trp Gly Tyr Ser Leu Ala Phe Ser Lys Ser Ala 65 70 75 80 ccg aat aat aaa ttc att ggg aat cta gat tcg ttt ggc ttt aga aac 288 Pro Asn Asn Lys Phe Ile Gly Asn Leu Asp Ser Phe Gly Phe Arg Asn 85 90 95 gtg tac gga aaa aaa ttc gat gaa gat gcc tac cct gag ctc gcg tat 336 Val Tyr Gly Lys Lys Phe Asp Glu Asp Ala Tyr Pro Glu Leu Ala Tyr 100 105 110 gca acc ttc caa atg atg ttt tcg tgc gtc aac tta agt att atc gct 384 Ala Thr Phe Gln Met Met Phe Ser Cys Val Asn Leu Ser Ile Ile Ala 115 120 125 ggc gcc act gcc gaa aga ggc agg ctg cta ccg cac atg gtt ttt ctc 432 Gly Ala Thr Ala Glu Arg Gly Arg Leu Leu Pro His Met Val Phe Leu 130 135 140 ttt att cta gct acc att gga tat tgt cca gtg acg tat tgg att tgg 480 Phe Ile Leu Ala Thr Ile Gly Tyr Cys Pro Val Thr Tyr Trp Ile Trp 145 150 155 160 tca cca ggt ggt tgg gca tac caa tgg gga gtc ctc gat tgg gca ggc 528 Ser Pro Gly Gly Trp Ala Tyr Gln Trp Gly Val Leu Asp Trp Ala Gly 165 170 175 ggc ggc aac att gaa ata tta agc gct gtt tcc ggg ttt gtt tac tct 576 Gly Gly Asn Ile Glu Ile Leu Ser Ala Val Ser Gly Phe Val Tyr Ser 180 185 190 tgg ttt ttg ggc aaa aga aat gaa aag tta ctg ata aat ttc agg cct 624 Trp Phe Leu Gly Lys Arg Asn Glu Lys Leu Leu Ile Asn Phe Arg Pro 195 200 205 cat aat gtt tca ttg gtc act cta ggc aca tcc ata ctg tgg ttt ggc 672 His Asn Val Ser Leu Val Thr Leu Gly Thr Ser Ile Leu Trp Phe Gly 210 215 220 tgg ctg cta ttt aat tct gca tcc tca tta tcc cca aat ttg agg tca 720 Trp Leu Leu Phe Asn Ser Ala Ser Ser Leu Ser Pro Asn Leu Arg Ser 225 230 235 240 gtt tat gca ttc atg aat aca tgt ctc agt gcc att act ggt ggg atg 768 Val Tyr Ala Phe Met Asn Thr Cys Leu Ser Ala Ile Thr Gly Gly Met 245 250 255 acg tgg tgt ctt ctg gat tac aga tcg gag aag aaa tgg tcg aca gtt 816 Thr Trp Cys Leu Leu Asp Tyr Arg Ser Glu Lys Lys Trp Ser Thr Val 260 265 270 ggt ctg tgc tcc ggt atc att tct ggg ctg gtg gct gca acg cca agc 864 Gly Leu Cys Ser Gly Ile Ile Ser Gly Leu Val Ala Ala Thr Pro Ser 275 280 285 tca ggc tgt ata acc ctt tac ggt tca ctt att caa ggc att gtg gcg 912 Ser Gly Cys Ile Thr Leu Tyr Gly Ser Leu Ile Gln Gly Ile Val Ala 290 295 300 ggg gta gtg tgt aac ttt gcg acg aag ttg aaa tac tac gct aaa gta 960 Gly Val Val Cys Asn Phe Ala Thr Lys Leu Lys Tyr Tyr Ala Lys Val 305 310 315 320 Page 109 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gat gat gcc atg gac att cta gct gag cac ggg gtt gca ggc gta ata 1008 Asp Asp Ala Met Asp Ile Leu Ala Glu His Gly Val Ala Gly Val Ile 325 330 335 gga cta att ttc aat gcc ctt ttt gga gca gac tgg gtc att ggt atg 1056 Gly Leu Ile Phe Asn Ala Leu Phe Gly Ala Asp Trp Val Ile Gly Met 340 345 350 gat ggc act aca gag cac gag ggc ggc tgg gta act cac aat tac aag 1104 Asp Gly Thr Thr Glu His Glu Gly Gly Trp Val Thr His Asn Tyr Lys 355 360 365 caa atg tat aag cag atc gct tac att gcc gca tcc att ggg tac act 1152 Gln Met Tyr Lys Gln Ile Ala Tyr Ile Ala Ala Ser Ile Gly Tyr Thr 370 375 380 gct gct gta act gca ata atc tgc ttt gtg ctc ggc tac ata ccc ggt 1200 Ala Ala Val Thr Ala Ile Ile Cys Phe Val Leu Gly Tyr Ile Pro Gly 385 390 395 400 atg agg cta aga ata tca gaa gag gca gag gag gcg ggt atg gac gaa 1248 Met Arg Leu Arg Ile Ser Glu Glu Ala Glu Glu Ala Gly Met Asp Glu 405 410 415 gat caa att ggc gaa ttt gcg tac gat tat gtg gaa gtg aga aga gat 1296 Asp Gln Ile Gly Glu Phe Ala Tyr Asp Tyr Val Glu Val Arg Arg Asp 420 425 430 tac tat cta tgg ggt gta gac gaa gat tca caa cgc tct gat gta aat 1344 Tyr Tyr Leu Trp Gly Val Asp Glu Asp Ser Gln Arg Ser Asp Val Asn 435 440 445 cac cgg gtg aac aac gct cat ttg gcc gct gaa cgt agc agt agc ggt 1392 His Arg Val Asn Asn Ala His Leu Ala Ala Glu Arg Ser Ser Ser Gly 450 455 460 act aat agt tcc tcg gat ggg aat gga gaa atg att caa tcc gaa aag 1440 Thr Asn Ser Ser Ser Asp Gly Asn Gly Glu Met Ile Gln Ser Glu Lys 465 470 475 480 atc cta cca att cat caa gaa gat cct gcc aat agg taa 1479 Ile Leu Pro Ile His Gln Glu Asp Pro Ala Asn Arg 485 490 <210> 73 <211> 492 <212> PRT <213> Saccharomyces cerevisiae <400> 73 Met Glu Ser Arg Thr Thr Gly Pro Leu Thr Thr Glu Thr Tyr Asp Gly 1 5 10 15 Pro Thr Val Ala Phe Met Ile Leu Gly Ala Ala Leu Val Phe Phe Met 20 25 30 Val Pro Gly Leu Gly Phe Leu Tyr Ser Gly Leu Ala Arg Arg Lys Ser 35 40 45 Ala Leu Ala Leu Ile Trp Val Val Leu Met Ala Thr Leu Val Gly Ile 50 55 60 Page 110 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Gln Trp Tyr Phe Trp Gly Tyr Ser Leu Ala Phe Ser Lys Ser Ala 65 70 75 80 Pro Asn Asn Lys Phe Ile Gly Asn Leu Asp Ser Phe Gly Phe Arg Asn 85 90 95 Val Tyr Gly Lys Lys Phe Asp Glu Asp Ala Tyr Pro Glu Leu Ala Tyr 100 105 110 Ala Thr Phe Gln Met Met Phe Ser Cys Val Asn Leu Ser Ile Ile Ala 115 120 125 Gly Ala Thr Ala Glu Arg Gly Arg Leu Leu Pro His Met Val Phe Leu 130 135 140 Phe Ile Leu Ala Thr Ile Gly Tyr Cys Pro Val Thr Tyr Trp Ile Trp 145 150 155 160 Ser Pro Gly Gly Trp Ala Tyr Gln Trp Gly Val Leu Asp Trp Ala Gly 165 170 175 Gly Gly Asn Ile Glu Ile Leu Ser Ala Val Ser Gly Phe Val Tyr Ser 180 185 190 Trp Phe Leu Gly Lys Arg Asn Glu Lys Leu Leu Ile Asn Phe Arg Pro 195 200 205 His Asn Val Ser Leu Val Thr Leu Gly Thr Ser Ile Leu Trp Phe Gly 210 215 220 Trp Leu Leu Phe Asn Ser Ala Ser Ser Leu Ser Pro Asn Leu Arg Ser 225 230 235 240 Val Tyr Ala Phe Met Asn Thr Cys Leu Ser Ala Ile Thr Gly Gly Met 245 250 255 Thr Trp Cys Leu Leu Asp Tyr Arg Ser Glu Lys Lys Trp Ser Thr Val 260 265 270 Gly Leu Cys Ser Gly Ile Ile Ser Gly Leu Val Ala Ala Thr Pro Ser 275 280 285 Ser Gly Cys Ile Thr Leu Tyr Gly Ser Leu Ile Gln Gly Ile Val Ala 290 295 300 Gly Val Val Cys Asn Phe Ala Thr Lys Leu Lys Tyr Tyr Ala Lys Val 305 310 315 320 Asp Asp Ala Met Asp Ile Leu Ala Glu His Gly Val Ala Gly Val Ile 325 330 335 Page 111 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Leu Ile Phe Asn Ala Leu Phe Gly Ala Asp Trp Val Ile Gly Met 340 345 350 Asp Gly Thr Thr Glu His Glu Gly Gly Trp Val Thr His Asn Tyr Lys 355 360 365 Gln Met Tyr Lys Gln Ile Ala Tyr Ile Ala Ala Ser Ile Gly Tyr Thr 370 375 380 Ala Ala Val Thr Ala Ile Ile Cys Phe Val Leu Gly Tyr Ile Pro Gly 385 390 395 400 Met Arg Leu Arg Ile Ser Glu Glu Ala Glu Glu Ala Gly Met Asp Glu 405 410 415 Asp Gln Ile Gly Glu Phe Ala Tyr Asp Tyr Val Glu Val Arg Arg Asp 420 425 430 Tyr Tyr Leu Trp Gly Val Asp Glu Asp Ser Gln Arg Ser Asp Val Asn 435 440 445 His Arg Val Asn Asn Ala His Leu Ala Ala Glu Arg Ser Ser Ser Gly 450 455 460 Thr Asn Ser Ser Ser Asp Gly Asn Gly Glu Met Ile Gln Ser Glu Lys 465 470 475 480 Ile Leu Pro Ile His Gln Glu Asp Pro Ala Asn Arg 485 490 <210> 74 <211> 939 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(939) <400> 74 atg tgc att tta atg gcc aca agg gca cat cct gac tat gaa ctc atc 48 Met Cys Ile Leu Met Ala Thr Arg Ala His Pro Asp Tyr Glu Leu Ile 1 5 10 15 tta ata tct aac aga gac gaa ttc ttg gca aga aaa aca cat gct aca 96 Leu Ile Ser Asn Arg Asp Glu Phe Leu Ala Arg Lys Thr His Ala Thr 20 25 30 tgc tgg cat aac aat gat ttt atc ctt tca ccc tac gat ctg gcc aaa 144 Cys Trp His Asn Asn Asp Phe Ile Leu Ser Pro Tyr Asp Leu Ala Lys 35 40 45 acc tca gca gaa aaa caa ata ttt ggc act tgg tct ggc ata aat aaa 192 Thr Ser Ala Glu Lys Gln Ile Phe Gly Thr Trp Ser Gly Ile Asn Lys 50 55 60 Page 112 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa gga aaa tta gcc act att ctt aat tta aaa ctt gac aat gag caa 240 Glu Gly Lys Leu Ala Thr Ile Leu Asn Leu Lys Leu Asp Asn Glu Gln 65 70 75 80 aat aat acg aaa tca aga tcc cgt ggt ctg tta cca ttt ata ttt ttg 288 Asn Asn Thr Lys Ser Arg Ser Arg Gly Leu Leu Pro Phe Ile Phe Leu 85 90 95 tcg atc cat aaa gca gat ttt gaa gat tgg gat aat tac aaa aag ttt 336 Ser Ile His Lys Ala Asp Phe Glu Asp Trp Asp Asn Tyr Lys Lys Phe 100 105 110 gaa ggt cac tat gat ggg ttg aag tcc aca ggt gat ttt aat ttt ttt 384 Glu Gly His Tyr Asp Gly Leu Lys Ser Thr Gly Asp Phe Asn Phe Phe 115 120 125 tac ggc gac gtt atc aaa aag caa tat aaa gtt att gat tct cta gga 432 Tyr Gly Asp Val Ile Lys Lys Gln Tyr Lys Val Ile Asp Ser Leu Gly 130 135 140 aga act ttt gat gtg ttg agt tct acc tgt agg aaa gat ctt gat tct 480 Arg Thr Phe Asp Val Leu Ser Ser Thr Cys Arg Lys Asp Leu Asp Ser 145 150 155 160 tac atg gtt gtt tct aat ggt aaa ttt tat gac agc tcc agt ata cca 528 Tyr Met Val Val Ser Asn Gly Lys Phe Tyr Asp Ser Ser Ser Ile Pro 165 170 175 ggg cag gct tgg gaa aaa gta aag gta gca cgt gat agt tta gaa aat 576 Gly Gln Ala Trp Glu Lys Val Lys Val Ala Arg Asp Ser Leu Glu Asn 180 185 190 cta gtt tta gag aat att gaa tca gat gag gag aaa ata ata tca agt 624 Leu Val Leu Glu Asn Ile Glu Ser Asp Glu Glu Lys Ile Ile Ser Ser 195 200 205 tgc ttt caa ctc gcc tcg aag tct tcc ctt cca agc act att tca aac 672 Cys Phe Gln Leu Ala Ser Lys Ser Ser Leu Pro Ser Thr Ile Ser Asn 210 215 220 cca gat gtc ttg cag atg gta gat cca aat gta acc atg aat acc ata 720 Pro Asp Val Leu Gln Met Val Asp Pro Asn Val Thr Met Asn Thr Ile 225 230 235 240 tac gta cca cct tta cgg agg cct ccc agg gat gac tta ggt gcc tca 768 Tyr Val Pro Pro Leu Arg Arg Pro Pro Arg Asp Asp Leu Gly Ala Ser 245 250 255 att cct gat ggt gat tac tac gga act cgc tct caa ata gtt tta ctc 816 Ile Pro Asp Gly Asp Tyr Tyr Gly Thr Arg Ser Gln Ile Val Leu Leu 260 265 270 gtg agt aag gat tca acg aga gtt acc ttt ata gaa agg gtc ctt tat 864 Val Ser Lys Asp Ser Thr Arg Val Thr Phe Ile Glu Arg Val Leu Tyr 275 280 285 agc tca gat gaa gac gtg cgc aag tat tcg gta acc tca cct aag gag 912 Ser Ser Asp Glu Asp Val Arg Lys Tyr Ser Val Thr Ser Pro Lys Glu 290 295 300 gaa aaa agg ttt aaa ttc aaa ttg taa 939 Glu Lys Arg Phe Lys Phe Lys Leu 305 310 <210> 75 <211> 312 Page 113 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> PRT <213> Saccharomyces cerevisiae <400> 75 Met Cys Ile Leu Met Ala Thr Arg Ala His Pro Asp Tyr Glu Leu Ile 1 5 10 15 Leu Ile Ser Asn Arg Asp Glu Phe Leu Ala Arg Lys Thr His Ala Thr 20 25 30 Cys Trp His Asn Asn Asp Phe Ile Leu Ser Pro Tyr Asp Leu Ala Lys 35 40 45 Thr Ser Ala Glu Lys Gln Ile Phe Gly Thr Trp Ser Gly Ile Asn Lys 50 55 60 Glu Gly Lys Leu Ala Thr Ile Leu Asn Leu Lys Leu Asp Asn Glu Gln 65 70 75 80 Asn Asn Thr Lys Ser Arg Ser Arg Gly Leu Leu Pro Phe Ile Phe Leu 85 90 95 Ser Ile His Lys Ala Asp Phe Glu Asp Trp Asp Asn Tyr Lys Lys Phe 100 105 110 Glu Gly His Tyr Asp Gly Leu Lys Ser Thr Gly Asp Phe Asn Phe Phe 115 120 125 Tyr Gly Asp Val Ile Lys Lys Gln Tyr Lys Val Ile Asp Ser Leu Gly 130 135 140 Arg Thr Phe Asp Val Leu Ser Ser Thr Cys Arg Lys Asp Leu Asp Ser 145 150 155 160 Tyr Met Val Val Ser Asn Gly Lys Phe Tyr Asp Ser Ser Ser Ile Pro 165 170 175 Gly Gln Ala Trp Glu Lys Val Lys Val Ala Arg Asp Ser Leu Glu Asn 180 185 190 Leu Val Leu Glu Asn Ile Glu Ser Asp Glu Glu Lys Ile Ile Ser Ser 195 200 205 Cys Phe Gln Leu Ala Ser Lys Ser Ser Leu Pro Ser Thr Ile Ser Asn 210 215 220 Pro Asp Val Leu Gln Met Val Asp Pro Asn Val Thr Met Asn Thr Ile 225 230 235 240 Tyr Val Pro Pro Leu Arg Arg Pro Pro Arg Asp Asp Leu Gly Ala Ser 245 250 255 Page 114 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Pro Asp Gly Asp Tyr Tyr Gly Thr Arg Ser Gln Ile Val Leu Leu 260 265 270 Val Ser Lys Asp Ser Thr Arg Val Thr Phe Ile Glu Arg Val Leu Tyr 275 280 285 Ser Ser Asp Glu Asp Val Arg Lys Tyr Ser Val Thr Ser Pro Lys Glu 290 295 300 Glu Lys Arg Phe Lys Phe Lys Leu 305 310 <210> 76 <211> 2595 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2595) <400> 76 atg tac atg gcc aga tgt ggc ccc aag aat aat gtg ctg tgt ttc cca 48 Met Tyr Met Ala Arg Cys Gly Pro Lys Asn Asn Val Leu Cys Phe Pro 1 5 10 15 ttt caa ctt tcc ttt cta ttt tca aaa cga cta ata aat aag cgt ttc 96 Phe Gln Leu Ser Phe Leu Phe Ser Lys Arg Leu Ile Asn Lys Arg Phe 20 25 30 aag tat acc cta caa act gaa gat gaa aag aat atg atg ggg agt tta 144 Lys Tyr Thr Leu Gln Thr Glu Asp Glu Lys Asn Met Met Gly Ser Leu 35 40 45 agt aaa aat aaa ata ata aca cct gaa gac gtt gag ttc aaa tta gca 192 Ser Lys Asn Lys Ile Ile Thr Pro Glu Asp Val Glu Phe Lys Leu Ala 50 55 60 caa tta cga gaa ttt tct aat act tta aaa gaa cgc att cac aac act 240 Gln Leu Arg Glu Phe Ser Asn Thr Leu Lys Glu Arg Ile His Asn Thr 65 70 75 80 aaa tcg gtg aat tca gat ggc cac caa agc aat agt atc gca cca atc 288 Lys Ser Val Asn Ser Asp Gly His Gln Ser Asn Ser Ile Ala Pro Ile 85 90 95 tca gaa gac tca agg aat gtt aat gtc acc aaa aca tca tct gtt cct 336 Ser Glu Asp Ser Arg Asn Val Asn Val Thr Lys Thr Ser Ser Val Pro 100 105 110 aat gaa gaa aaa tcc aaa aat cta tca gat ttg att cat tct tcg ttt 384 Asn Glu Glu Lys Ser Lys Asn Leu Ser Asp Leu Ile His Ser Ser Phe 115 120 125 tta gaa aaa atg gat cac ctc gta cca aaa gtt ata aga gaa aga gta 432 Leu Glu Lys Met Asp His Leu Val Pro Lys Val Ile Arg Glu Arg Val 130 135 140 gca gac gac gac ata ctt gca aaa aac ctt ttt gat aga tca cac agt 480 Ala Asp Asp Asp Ile Leu Ala Lys Asn Leu Phe Asp Arg Ser His Ser 145 150 155 160 Page 115 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aat tgg gca cct gtc ata gat agg ctt tat gtc agt gag aaa cgg ttc 528 Asn Trp Ala Pro Val Ile Asp Arg Leu Tyr Val Ser Glu Lys Arg Phe 165 170 175 atg gat att gat tcc aga gaa ttt tct gtt tgg tta aat ggt aca gtc 576 Met Asp Ile Asp Ser Arg Glu Phe Ser Val Trp Leu Asn Gly Thr Val 180 185 190 aaa tat ttg cca ttt cat agt ata cta cac ttg gat gaa atg cta tta 624 Lys Tyr Leu Pro Phe His Ser Ile Leu His Leu Asp Glu Met Leu Leu 195 200 205 gaa caa atc aat gga gat gtt gta aaa ttt aat acc cac atg tac gaa 672 Glu Gln Ile Asn Gly Asp Val Val Lys Phe Asn Thr His Met Tyr Glu 210 215 220 tgt atc ttt aac aac tta gga aat tta aaa cca act aat ttt aat cag 720 Cys Ile Phe Asn Asn Leu Gly Asn Leu Lys Pro Thr Asn Phe Asn Gln 225 230 235 240 gat ggt act aac gat aaa gtt atc ctc aaa atg aaa gag ttg tta gag 768 Asp Gly Thr Asn Asp Lys Val Ile Leu Lys Met Lys Glu Leu Leu Glu 245 250 255 agg tat gat aag gca tta aaa ata act gaa gaa aga att aac aaa aaa 816 Arg Tyr Asp Lys Ala Leu Lys Ile Thr Glu Glu Arg Ile Asn Lys Lys 260 265 270 gaa gga ttc cct tcc aaa gta cca aag atg acg caa gca ata ctt aat 864 Glu Gly Phe Pro Ser Lys Val Pro Lys Met Thr Gln Ala Ile Leu Asn 275 280 285 aat tgt tta aaa tac tcg acc aag tgt tca agc ttt cac gac atg gat 912 Asn Cys Leu Lys Tyr Ser Thr Lys Cys Ser Ser Phe His Asp Met Asp 290 295 300 tat ttt att aca aaa ttc aga gat gat tat ggc ata act cct aat aag 960 Tyr Phe Ile Thr Lys Phe Arg Asp Asp Tyr Gly Ile Thr Pro Asn Lys 305 310 315 320 caa aac cta act act gta ata caa ttc tac tct agg aag gaa atg act 1008 Gln Asn Leu Thr Thr Val Ile Gln Phe Tyr Ser Arg Lys Glu Met Thr 325 330 335 aag caa gcc tgg aat act ttt gac acc atg aaa ttt tta tct aca aag 1056 Lys Gln Ala Trp Asn Thr Phe Asp Thr Met Lys Phe Leu Ser Thr Lys 340 345 350 cat ttc cct gat atc tgc aca tat aac aca atg ctg cga ata tgc gag 1104 His Phe Pro Asp Ile Cys Thr Tyr Asn Thr Met Leu Arg Ile Cys Glu 355 360 365 aag gaa cgg aat ttt cct aag gct ttg gat tta ttt caa gaa att caa 1152 Lys Glu Arg Asn Phe Pro Lys Ala Leu Asp Leu Phe Gln Glu Ile Gln 370 375 380 gac cac aat ata aag cct aca aca aac act tac ata atg atg gca aga 1200 Asp His Asn Ile Lys Pro Thr Thr Asn Thr Tyr Ile Met Met Ala Arg 385 390 395 400 gtg ttg gct tct tcg agc agt aat gcc gtt gtc agt gag ggt aaa tca 1248 Val Leu Ala Ser Ser Ser Ser Asn Ala Val Val Ser Glu Gly Lys Ser 405 410 415 gac tct cta aga tta ctg gga tgg aaa tac ctt cat gag ttg gag gac 1296 Asp Ser Leu Arg Leu Leu Gly Trp Lys Tyr Leu His Glu Leu Glu Asp 420 425 430 Page 116 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag aat ctt tac aga cat aaa aaa gat gac tta aat tta ttt ttg gct 1344 Lys Asn Leu Tyr Arg His Lys Lys Asp Asp Leu Asn Leu Phe Leu Ala 435 440 445 atg atg gca tta gcc gcg ttt gat ggt gat att gaa tta agt aga gct 1392 Met Met Ala Leu Ala Ala Phe Asp Gly Asp Ile Glu Leu Ser Arg Ala 450 455 460 cta tat tac ttg ttc atc gcg aaa aag tac aaa act ttg tgc gca aat 1440 Leu Tyr Tyr Leu Phe Ile Ala Lys Lys Tyr Lys Thr Leu Cys Ala Asn 465 470 475 480 tgg aaa gga aac att ctc gta gat caa gat aca att tgg aag tca act 1488 Trp Lys Gly Asn Ile Leu Val Asp Gln Asp Thr Ile Trp Lys Ser Thr 485 490 495 tta atg cca gaa atg ctg aat tat ttg atg ctt gct tat gca aga ttt 1536 Leu Met Pro Glu Met Leu Asn Tyr Leu Met Leu Ala Tyr Ala Arg Phe 500 505 510 gat ccc aga aat ttg cca gtc tta tcc ggt tat gaa aaa ggc att gaa 1584 Asp Pro Arg Asn Leu Pro Val Leu Ser Gly Tyr Glu Lys Gly Ile Glu 515 520 525 ttg aga aga aaa ttt ctt cgc gaa ttt gat tcc tcc atg agg tta gat 1632 Leu Arg Arg Lys Phe Leu Arg Glu Phe Asp Ser Ser Met Arg Leu Asp 530 535 540 gat aca gac aaa ttg gtc aaa ttt aaa tta cca ttt ctt cca att agt 1680 Asp Thr Asp Lys Leu Val Lys Phe Lys Leu Pro Phe Leu Pro Ile Ser 545 550 555 560 gac cta aat tcg gag gca caa gta ttg gcg gaa tct aac gca atc tgg 1728 Asp Leu Asn Ser Glu Ala Gln Val Leu Ala Glu Ser Asn Ala Ile Trp 565 570 575 agt ttc aat atg gaa aat gga gga acg cgc aat aca ttg aca tct tca 1776 Ser Phe Asn Met Glu Asn Gly Gly Thr Arg Asn Thr Leu Thr Ser Ser 580 585 590 aat gaa gcg gcg ttg gag gat atc aaa aaa tat agg caa tta ctt gat 1824 Asn Glu Ala Ala Leu Glu Asp Ile Lys Lys Tyr Arg Gln Leu Leu Asp 595 600 605 tcg ttt gcg caa gaa gca gag gat ttc aac gag ttt aag ttt aaa gtt 1872 Ser Phe Ala Gln Glu Ala Glu Asp Phe Asn Glu Phe Lys Phe Lys Val 610 615 620 atg tac gaa gtg acg aaa atg caa aga gaa agt att aat gtg aac gtc 1920 Met Tyr Glu Val Thr Lys Met Gln Arg Glu Ser Ile Asn Val Asn Val 625 630 635 640 ttc aat aaa att tca cta cac aca tat ttg tca att ccc att aac tta 1968 Phe Asn Lys Ile Ser Leu His Thr Tyr Leu Ser Ile Pro Ile Asn Leu 645 650 655 aaa caa cag aag gaa ttc ttg cga agg ttg acg ttc ttc act ttc caa 2016 Lys Gln Gln Lys Glu Phe Leu Arg Arg Leu Thr Phe Phe Thr Phe Gln 660 665 670 caa cac gaa ttt gaa gct gtc ata aag cgt ttg tat gaa gga tac cgt 2064 Gln His Glu Phe Glu Ala Val Ile Lys Arg Leu Tyr Glu Gly Tyr Arg 675 680 685 aat att cct tcg tcc cat acg cgt gac caa aat tca ata tca act gaa 2112 Asn Ile Pro Ser Ser His Thr Arg Asp Gln Asn Ser Ile Ser Thr Glu 690 695 700 Page 117 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gcc atc tca gta tcc aaa cct gag acc acg gaa gac ctc aac tta ata 2160 Ala Ile Ser Val Ser Lys Pro Glu Thr Thr Glu Asp Leu Asn Leu Ile 705 710 715 720 atg cat gat ata tgg tat att aca tgt ttg agg cac aaa atc atg atg 2208 Met His Asp Ile Trp Tyr Ile Thr Cys Leu Arg His Lys Ile Met Met 725 730 735 gac acc acg tta tat gag ctg gtg atg aaa gcc gct ata gaa ttt caa 2256 Asp Thr Thr Leu Tyr Glu Leu Val Met Lys Ala Ala Ile Glu Phe Gln 740 745 750 aat gag gac tta gca aag aaa gta tgg aat gat agg ggt aaa ttt agg 2304 Asn Glu Asp Leu Ala Lys Lys Val Trp Asn Asp Arg Gly Lys Phe Arg 755 760 765 acg act gta ccg ttt ctg aaa atg gac caa aga ata aga ata gca aag 2352 Thr Thr Val Pro Phe Leu Lys Met Asp Gln Arg Ile Arg Ile Ala Lys 770 775 780 gat cag aaa ttt gcc cat cta atg gtt gaa ttc ttc aca aag caa gga 2400 Asp Gln Lys Phe Ala His Leu Met Val Glu Phe Phe Thr Lys Gln Gly 785 790 795 800 aag tat tcg gac gca ata gct atc ata ttg tct tca aaa aat cgc ttc 2448 Lys Tyr Ser Asp Ala Ile Ala Ile Ile Leu Ser Ser Lys Asn Arg Phe 805 810 815 aat tgg act tat tcc atg gtt agg aat ttg cat aaa gca tta gaa gaa 2496 Asn Trp Thr Tyr Ser Met Val Arg Asn Leu His Lys Ala Leu Glu Glu 820 825 830 atc gag gat aga aat agc gtt gaa atc tta ctg gat gta gta aac aaa 2544 Ile Glu Asp Arg Asn Ser Val Glu Ile Leu Leu Asp Val Val Asn Lys 835 840 845 aag tca cac gca aag gcc ctg aag tgg gag gaa caa gaa ctt aac atg 2592 Lys Ser His Ala Lys Ala Leu Lys Trp Glu Glu Gln Glu Leu Asn Met 850 855 860 tag 2595 <210> 77 <211> 864 <212> PRT <213> Saccharomyces cerevisiae <400> 77 Met Tyr Met Ala Arg Cys Gly Pro Lys Asn Asn Val Leu Cys Phe Pro 1 5 10 15 Phe Gln Leu Ser Phe Leu Phe Ser Lys Arg Leu Ile Asn Lys Arg Phe 20 25 30 Lys Tyr Thr Leu Gln Thr Glu Asp Glu Lys Asn Met Met Gly Ser Leu 35 40 45 Ser Lys Asn Lys Ile Ile Thr Pro Glu Asp Val Glu Phe Lys Leu Ala 50 55 60 Gln Leu Arg Glu Phe Ser Asn Thr Leu Lys Glu Arg Ile His Asn Thr 65 70 75 80 Page 118 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Ser Val Asn Ser Asp Gly His Gln Ser Asn Ser Ile Ala Pro Ile 85 90 95 Ser Glu Asp Ser Arg Asn Val Asn Val Thr Lys Thr Ser Ser Val Pro 100 105 110 Asn Glu Glu Lys Ser Lys Asn Leu Ser Asp Leu Ile His Ser Ser Phe 115 120 125 Leu Glu Lys Met Asp His Leu Val Pro Lys Val Ile Arg Glu Arg Val 130 135 140 Ala Asp Asp Asp Ile Leu Ala Lys Asn Leu Phe Asp Arg Ser His Ser 145 150 155 160 Asn Trp Ala Pro Val Ile Asp Arg Leu Tyr Val Ser Glu Lys Arg Phe 165 170 175 Met Asp Ile Asp Ser Arg Glu Phe Ser Val Trp Leu Asn Gly Thr Val 180 185 190 Lys Tyr Leu Pro Phe His Ser Ile Leu His Leu Asp Glu Met Leu Leu 195 200 205 Glu Gln Ile Asn Gly Asp Val Val Lys Phe Asn Thr His Met Tyr Glu 210 215 220 Cys Ile Phe Asn Asn Leu Gly Asn Leu Lys Pro Thr Asn Phe Asn Gln 225 230 235 240 Asp Gly Thr Asn Asp Lys Val Ile Leu Lys Met Lys Glu Leu Leu Glu 245 250 255 Arg Tyr Asp Lys Ala Leu Lys Ile Thr Glu Glu Arg Ile Asn Lys Lys 260 265 270 Glu Gly Phe Pro Ser Lys Val Pro Lys Met Thr Gln Ala Ile Leu Asn 275 280 285 Asn Cys Leu Lys Tyr Ser Thr Lys Cys Ser Ser Phe His Asp Met Asp 290 295 300 Tyr Phe Ile Thr Lys Phe Arg Asp Asp Tyr Gly Ile Thr Pro Asn Lys 305 310 315 320 Gln Asn Leu Thr Thr Val Ile Gln Phe Tyr Ser Arg Lys Glu Met Thr 325 330 335 Lys Gln Ala Trp Asn Thr Phe Asp Thr Met Lys Phe Leu Ser Thr Lys 340 345 350 Page 119 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt His Phe Pro Asp Ile Cys Thr Tyr Asn Thr Met Leu Arg Ile Cys Glu 355 360 365 Lys Glu Arg Asn Phe Pro Lys Ala Leu Asp Leu Phe Gln Glu Ile Gln 370 375 380 Asp His Asn Ile Lys Pro Thr Thr Asn Thr Tyr Ile Met Met Ala Arg 385 390 395 400 Val Leu Ala Ser Ser Ser Ser Asn Ala Val Val Ser Glu Gly Lys Ser 405 410 415 Asp Ser Leu Arg Leu Leu Gly Trp Lys Tyr Leu His Glu Leu Glu Asp 420 425 430 Lys Asn Leu Tyr Arg His Lys Lys Asp Asp Leu Asn Leu Phe Leu Ala 435 440 445 Met Met Ala Leu Ala Ala Phe Asp Gly Asp Ile Glu Leu Ser Arg Ala 450 455 460 Leu Tyr Tyr Leu Phe Ile Ala Lys Lys Tyr Lys Thr Leu Cys Ala Asn 465 470 475 480 Trp Lys Gly Asn Ile Leu Val Asp Gln Asp Thr Ile Trp Lys Ser Thr 485 490 495 Leu Met Pro Glu Met Leu Asn Tyr Leu Met Leu Ala Tyr Ala Arg Phe 500 505 510 Asp Pro Arg Asn Leu Pro Val Leu Ser Gly Tyr Glu Lys Gly Ile Glu 515 520 525 Leu Arg Arg Lys Phe Leu Arg Glu Phe Asp Ser Ser Met Arg Leu Asp 530 535 540 Asp Thr Asp Lys Leu Val Lys Phe Lys Leu Pro Phe Leu Pro Ile Ser 545 550 555 560 Asp Leu Asn Ser Glu Ala Gln Val Leu Ala Glu Ser Asn Ala Ile Trp 565 570 575 Ser Phe Asn Met Glu Asn Gly Gly Thr Arg Asn Thr Leu Thr Ser Ser 580 585 590 Asn Glu Ala Ala Leu Glu Asp Ile Lys Lys Tyr Arg Gln Leu Leu Asp 595 600 605 Ser Phe Ala Gln Glu Ala Glu Asp Phe Asn Glu Phe Lys Phe Lys Val Page 120 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 610 615 620 Met Tyr Glu Val Thr Lys Met Gln Arg Glu Ser Ile Asn Val Asn Val 625 630 635 640 Phe Asn Lys Ile Ser Leu His Thr Tyr Leu Ser Ile Pro Ile Asn Leu 645 650 655 Lys Gln Gln Lys Glu Phe Leu Arg Arg Leu Thr Phe Phe Thr Phe Gln 660 665 670 Gln His Glu Phe Glu Ala Val Ile Lys Arg Leu Tyr Glu Gly Tyr Arg 675 680 685 Asn Ile Pro Ser Ser His Thr Arg Asp Gln Asn Ser Ile Ser Thr Glu 690 695 700 Ala Ile Ser Val Ser Lys Pro Glu Thr Thr Glu Asp Leu Asn Leu Ile 705 710 715 720 Met His Asp Ile Trp Tyr Ile Thr Cys Leu Arg His Lys Ile Met Met 725 730 735 Asp Thr Thr Leu Tyr Glu Leu Val Met Lys Ala Ala Ile Glu Phe Gln 740 745 750 Asn Glu Asp Leu Ala Lys Lys Val Trp Asn Asp Arg Gly Lys Phe Arg 755 760 765 Thr Thr Val Pro Phe Leu Lys Met Asp Gln Arg Ile Arg Ile Ala Lys 770 775 780 Asp Gln Lys Phe Ala His Leu Met Val Glu Phe Phe Thr Lys Gln Gly 785 790 795 800 Lys Tyr Ser Asp Ala Ile Ala Ile Ile Leu Ser Ser Lys Asn Arg Phe 805 810 815 Asn Trp Thr Tyr Ser Met Val Arg Asn Leu His Lys Ala Leu Glu Glu 820 825 830 Ile Glu Asp Arg Asn Ser Val Glu Ile Leu Leu Asp Val Val Asn Lys 835 840 845 Lys Ser His Ala Lys Ala Leu Lys Trp Glu Glu Gln Glu Leu Asn Met 850 855 860 <210> 78 <211> 357 <212> DNA <213> Saccharomyces cerevisiae Page 121 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(357) <400> 78 atg cag aca atg ggc ggg gag cac ctt ctt ctt tca cag cta aag ggg 48 Met Gln Thr Met Gly Gly Glu His Leu Leu Leu Ser Gln Leu Lys Gly 1 5 10 15 tct ttc ttt ctc cta ctt ttg gca tac ttt ttc agg ggc aga agt cct 96 Ser Phe Phe Leu Leu Leu Leu Ala Tyr Phe Phe Arg Gly Arg Ser Pro 20 25 30 tat tac gca cgt tgc tac cgc cgg ctt gct gtt aca cct ggt gcc atc 144 Tyr Tyr Ala Arg Cys Tyr Arg Arg Leu Ala Val Thr Pro Gly Ala Ile 35 40 45 act att gcc att gcc att gct aca gat tca att ccg gcg ctt gca aag 192 Thr Ile Ala Ile Ala Ile Ala Thr Asp Ser Ile Pro Ala Leu Ala Lys 50 55 60 tcc aaa gtt ctg gtg tcg gtt tgt tct cac aca gat ccc tgt aca gcg 240 Ser Lys Val Leu Val Ser Val Cys Ser His Thr Asp Pro Cys Thr Ala 65 70 75 80 tct tgt aac ctg atc ccc ttc ccc cgc ccc ttc tcg aac agc ctg acg 288 Ser Cys Asn Leu Ile Pro Phe Pro Arg Pro Phe Ser Asn Ser Leu Thr 85 90 95 cgc ttc ctc ttt tgt ttg ggc tcg gcc cgt ttt tgc att tcc ttt ccc 336 Arg Phe Leu Phe Cys Leu Gly Ser Ala Arg Phe Cys Ile Ser Phe Pro 100 105 110 tgt ttt gga ttg agt ata taa 357 Cys Phe Gly Leu Ser Ile 115 <210> 79 <211> 118 <212> PRT <213> Saccharomyces cerevisiae <400> 79 Met Gln Thr Met Gly Gly Glu His Leu Leu Leu Ser Gln Leu Lys Gly 1 5 10 15 Ser Phe Phe Leu Leu Leu Leu Ala Tyr Phe Phe Arg Gly Arg Ser Pro 20 25 30 Tyr Tyr Ala Arg Cys Tyr Arg Arg Leu Ala Val Thr Pro Gly Ala Ile 35 40 45 Thr Ile Ala Ile Ala Ile Ala Thr Asp Ser Ile Pro Ala Leu Ala Lys 50 55 60 Ser Lys Val Leu Val Ser Val Cys Ser His Thr Asp Pro Cys Thr Ala 65 70 75 80 Ser Cys Asn Leu Ile Pro Phe Pro Arg Pro Phe Ser Asn Ser Leu Thr 85 90 95 Page 122 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Phe Leu Phe Cys Leu Gly Ser Ala Arg Phe Cys Ile Ser Phe Pro 100 105 110 Cys Phe Gly Leu Ser Ile 115 <210> 80 <211> 1062 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1062) <400> 80 atg att caa ttt aaa agt cca ggt aac tgg ctg ttc ata gta ccc tgg 48 Met Ile Gln Phe Lys Ser Pro Gly Asn Trp Leu Phe Ile Val Pro Trp 1 5 10 15 att gcc ttc att cca tgg tat ggt atg ctg ata gcc atg ctt att tgc 96 Ile Ala Phe Ile Pro Trp Tyr Gly Met Leu Ile Ala Met Leu Ile Cys 20 25 30 tgg gcc agt caa ggc cat ccc ata tat tgg ttc atg cac tcg gag caa 144 Trp Ala Ser Gln Gly His Pro Ile Tyr Trp Phe Met His Ser Glu Gln 35 40 45 ttc cct gtg tac att tca gat ata ggt gcc act aat tta agg cca ctg 192 Phe Pro Val Tyr Ile Ser Asp Ile Gly Ala Thr Asn Leu Arg Pro Leu 50 55 60 ttt ata tcg tgc gcc ggc tgg cag ggt cta ggc tat gta atc act gtt 240 Phe Ile Ser Cys Ala Gly Trp Gln Gly Leu Gly Tyr Val Ile Thr Val 65 70 75 80 gcc ctt gag ttt ttt caa aga tcc ggc tat ctg cct ttc caa ctg aaa 288 Ala Leu Glu Phe Phe Gln Arg Ser Gly Tyr Leu Pro Phe Gln Leu Lys 85 90 95 aaa aaa gac cct tct atc tct gat tcc aca tct tat gct gag aaa ttg 336 Lys Lys Asp Pro Ser Ile Ser Asp Ser Thr Ser Tyr Ala Glu Lys Leu 100 105 110 cac agc ggt aaa tac tta atg cct cca tat tac aca aag gat gaa cgg 384 His Ser Gly Lys Tyr Leu Met Pro Pro Tyr Tyr Thr Lys Asp Glu Arg 115 120 125 aac ctg att ttc gca gct ttt gtt ctc ggc agc att ggt gaa cta gcc 432 Asn Leu Ile Phe Ala Ala Phe Val Leu Gly Ser Ile Gly Glu Leu Ala 130 135 140 ctt tta ttc agt tcc atc ttc tca acc gcc ctg tac cat cgc gtt cac 480 Leu Leu Phe Ser Ser Ile Phe Ser Thr Ala Leu Tyr His Arg Val His 145 150 155 160 att gct atg gtc tct gtt ttc gtc gtc ttc atg ttc cta tcc act tgc 528 Ile Ala Met Val Ser Val Phe Val Val Phe Met Phe Leu Ser Thr Cys 165 170 175 tgc ttg att gca gag tat ttc ctc atg gga agg cac tat gcc tca gtc 576 Cys Leu Ile Ala Glu Tyr Phe Leu Met Gly Arg His Tyr Ala Ser Val 180 185 190 Page 123 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cac ccc cta gcc agc cct cat ttc aat cct caa tca tct gaa aaa agc 624 His Pro Leu Ala Ser Pro His Phe Asn Pro Gln Ser Ser Glu Lys Ser 195 200 205 ttt aac caa gat tat aac act gtg gat gag ctg cct tgg tat aaa tgg 672 Phe Asn Gln Asp Tyr Asn Thr Val Asp Glu Leu Pro Trp Tyr Lys Trp 210 215 220 aaa ggc cat gta tgg aat aaa ttt acc atc agt gca act cta aaa gtt 720 Lys Gly His Val Trp Asn Lys Phe Thr Ile Ser Ala Thr Leu Lys Val 225 230 235 240 ata tgg tta act ctc gca gtt gta tgg gcc att tgt ttt ggt gct atc 768 Ile Trp Leu Thr Leu Ala Val Val Trp Ala Ile Cys Phe Gly Ala Ile 245 250 255 aat gat aga tct aag agt gct tgt ttc gaa tgg ttg cta gca ttt tgg 816 Asn Asp Arg Ser Lys Ser Ala Cys Phe Glu Trp Leu Leu Ala Phe Trp 260 265 270 ttt ggt atc ata ttt atg att ctt tcc gcc gac ttt tat tta ggt gga 864 Phe Gly Ile Ile Phe Met Ile Leu Ser Ala Asp Phe Tyr Leu Gly Gly 275 280 285 aga tac aga caa tcc cgc tat ttc aac cac gtg gaa tca ttt tcg ggt 912 Arg Tyr Arg Gln Ser Arg Tyr Phe Asn His Val Glu Ser Phe Ser Gly 290 295 300 tat tac aag tat gac aag gcg cta ggc ctc tac cac agt gaa gac gtt 960 Tyr Tyr Lys Tyr Asp Lys Ala Leu Gly Leu Tyr His Ser Glu Asp Val 305 310 315 320 ttg cct tcg gac gat aac gcc ggc gtg att gcc aca gaa aca gca tct 1008 Leu Pro Ser Asp Asp Asn Ala Gly Val Ile Ala Thr Glu Thr Ala Ser 325 330 335 tca aat att tac aat aat tcc tct tcc aac gaa tct att caa gta gtc 1056 Ser Asn Ile Tyr Asn Asn Ser Ser Ser Asn Glu Ser Ile Gln Val Val 340 345 350 gta tga 1062 Val <210> 81 <211> 353 <212> PRT <213> Saccharomyces cerevisiae <400> 81 Met Ile Gln Phe Lys Ser Pro Gly Asn Trp Leu Phe Ile Val Pro Trp 1 5 10 15 Ile Ala Phe Ile Pro Trp Tyr Gly Met Leu Ile Ala Met Leu Ile Cys 20 25 30 Trp Ala Ser Gln Gly His Pro Ile Tyr Trp Phe Met His Ser Glu Gln 35 40 45 Phe Pro Val Tyr Ile Ser Asp Ile Gly Ala Thr Asn Leu Arg Pro Leu 50 55 60 Page 124 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Ile Ser Cys Ala Gly Trp Gln Gly Leu Gly Tyr Val Ile Thr Val 65 70 75 80 Ala Leu Glu Phe Phe Gln Arg Ser Gly Tyr Leu Pro Phe Gln Leu Lys 85 90 95 Lys Lys Asp Pro Ser Ile Ser Asp Ser Thr Ser Tyr Ala Glu Lys Leu 100 105 110 His Ser Gly Lys Tyr Leu Met Pro Pro Tyr Tyr Thr Lys Asp Glu Arg 115 120 125 Asn Leu Ile Phe Ala Ala Phe Val Leu Gly Ser Ile Gly Glu Leu Ala 130 135 140 Leu Leu Phe Ser Ser Ile Phe Ser Thr Ala Leu Tyr His Arg Val His 145 150 155 160 Ile Ala Met Val Ser Val Phe Val Val Phe Met Phe Leu Ser Thr Cys 165 170 175 Cys Leu Ile Ala Glu Tyr Phe Leu Met Gly Arg His Tyr Ala Ser Val 180 185 190 His Pro Leu Ala Ser Pro His Phe Asn Pro Gln Ser Ser Glu Lys Ser 195 200 205 Phe Asn Gln Asp Tyr Asn Thr Val Asp Glu Leu Pro Trp Tyr Lys Trp 210 215 220 Lys Gly His Val Trp Asn Lys Phe Thr Ile Ser Ala Thr Leu Lys Val 225 230 235 240 Ile Trp Leu Thr Leu Ala Val Val Trp Ala Ile Cys Phe Gly Ala Ile 245 250 255 Asn Asp Arg Ser Lys Ser Ala Cys Phe Glu Trp Leu Leu Ala Phe Trp 260 265 270 Phe Gly Ile Ile Phe Met Ile Leu Ser Ala Asp Phe Tyr Leu Gly Gly 275 280 285 Arg Tyr Arg Gln Ser Arg Tyr Phe Asn His Val Glu Ser Phe Ser Gly 290 295 300 Tyr Tyr Lys Tyr Asp Lys Ala Leu Gly Leu Tyr His Ser Glu Asp Val 305 310 315 320 Leu Pro Ser Asp Asp Asn Ala Gly Val Ile Ala Thr Glu Thr Ala Ser 325 330 335 Page 125 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Asn Ile Tyr Asn Asn Ser Ser Ser Asn Glu Ser Ile Gln Val Val 340 345 350 Val <210> 82 <211> 975 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(975) <400> 82 atg tca tct gac aac tct aaa caa gat aaa caa att gaa aaa aca gcc 48 Met Ser Ser Asp Asn Ser Lys Gln Asp Lys Gln Ile Glu Lys Thr Ala 1 5 10 15 gcc cag aag ata tcg aag ttt ggt tcg ttt gtg gct ggt ggg cta gca 96 Ala Gln Lys Ile Ser Lys Phe Gly Ser Phe Val Ala Gly Gly Leu Ala 20 25 30 gca tgt ata gct gtt aca gtt act aat ccg atc gaa ttg att aaa atc 144 Ala Cys Ile Ala Val Thr Val Thr Asn Pro Ile Glu Leu Ile Lys Ile 35 40 45 aga atg cag ctt caa ggt gaa atg tca gca tca gct gca aaa gtt tat 192 Arg Met Gln Leu Gln Gly Glu Met Ser Ala Ser Ala Ala Lys Val Tyr 50 55 60 aaa aat cca atc caa ggt atg gcg gta att ttc aaa aac gaa ggt ata 240 Lys Asn Pro Ile Gln Gly Met Ala Val Ile Phe Lys Asn Glu Gly Ile 65 70 75 80 aaa ggt ctg caa aaa ggg tta aat gct gct tat atc tat caa att ggg 288 Lys Gly Leu Gln Lys Gly Leu Asn Ala Ala Tyr Ile Tyr Gln Ile Gly 85 90 95 cta aat ggt tcc aga tta ggg ttt tat gag cca atc aga tca tca tta 336 Leu Asn Gly Ser Arg Leu Gly Phe Tyr Glu Pro Ile Arg Ser Ser Leu 100 105 110 aat cag ctt ttc ttc cca gat caa gag cca cat aag gta cag agc gtc 384 Asn Gln Leu Phe Phe Pro Asp Gln Glu Pro His Lys Val Gln Ser Val 115 120 125 gga gtt aac gtc ttt tct ggt gcc gca tct ggt ata att ggt gca gtc 432 Gly Val Asn Val Phe Ser Gly Ala Ala Ser Gly Ile Ile Gly Ala Val 130 135 140 att ggc tct cca tta ttc ttg gtg aaa aca aga ctt caa tca tat tcc 480 Ile Gly Ser Pro Leu Phe Leu Val Lys Thr Arg Leu Gln Ser Tyr Ser 145 150 155 160 gag ttt ata aaa att ggt gaa caa acg cac tac acc ggt gtt tgg aac 528 Glu Phe Ile Lys Ile Gly Glu Gln Thr His Tyr Thr Gly Val Trp Asn 165 170 175 ggg tta gta acc att ttt aaa acc gaa ggt gtt aag ggt cta ttc aga 576 Gly Leu Val Thr Ile Phe Lys Thr Glu Gly Val Lys Gly Leu Phe Arg 180 185 190 Page 126 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggt att gat gcg gca att tta agg aca ggt gct ggt tcc tct gtt caa 624 Gly Ile Asp Ala Ala Ile Leu Arg Thr Gly Ala Gly Ser Ser Val Gln 195 200 205 cta cct atc tac aac aca gca aag aac att ttg gtc aaa aat gat ctg 672 Leu Pro Ile Tyr Asn Thr Ala Lys Asn Ile Leu Val Lys Asn Asp Leu 210 215 220 atg aaa gat ggc cca gca tta cat tta act gct agt act atc tct ggg 720 Met Lys Asp Gly Pro Ala Leu His Leu Thr Ala Ser Thr Ile Ser Gly 225 230 235 240 tta ggt gtt gcc gtc gtt atg aac cca tgg gat gtc att ttg aca aga 768 Leu Gly Val Ala Val Val Met Asn Pro Trp Asp Val Ile Leu Thr Arg 245 250 255 atc tat aat caa aaa ggt gac ttg tac aag gga cct ata gat tgt ttg 816 Ile Tyr Asn Gln Lys Gly Asp Leu Tyr Lys Gly Pro Ile Asp Cys Leu 260 265 270 gtc aaa act gtt aga atc gaa ggt gta acc gct ttg tat aag ggt ttt 864 Val Lys Thr Val Arg Ile Glu Gly Val Thr Ala Leu Tyr Lys Gly Phe 275 280 285 gca gct caa gtg ttc aga atc gca cct cat aca atc atg tgt ttg acc 912 Ala Ala Gln Val Phe Arg Ile Ala Pro His Thr Ile Met Cys Leu Thr 290 295 300 ttc atg gaa cag aca atg aaa cta gtt tat tcg ata gag tcg aga gtt 960 Phe Met Glu Gln Thr Met Lys Leu Val Tyr Ser Ile Glu Ser Arg Val 305 310 315 320 tta ggc cat aat taa 975 Leu Gly His Asn <210> 83 <211> 324 <212> PRT <213> Saccharomyces cerevisiae <400> 83 Met Ser Ser Asp Asn Ser Lys Gln Asp Lys Gln Ile Glu Lys Thr Ala 1 5 10 15 Ala Gln Lys Ile Ser Lys Phe Gly Ser Phe Val Ala Gly Gly Leu Ala 20 25 30 Ala Cys Ile Ala Val Thr Val Thr Asn Pro Ile Glu Leu Ile Lys Ile 35 40 45 Arg Met Gln Leu Gln Gly Glu Met Ser Ala Ser Ala Ala Lys Val Tyr 50 55 60 Lys Asn Pro Ile Gln Gly Met Ala Val Ile Phe Lys Asn Glu Gly Ile 65 70 75 80 Lys Gly Leu Gln Lys Gly Leu Asn Ala Ala Tyr Ile Tyr Gln Ile Gly 85 90 95 Page 127 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Asn Gly Ser Arg Leu Gly Phe Tyr Glu Pro Ile Arg Ser Ser Leu 100 105 110 Asn Gln Leu Phe Phe Pro Asp Gln Glu Pro His Lys Val Gln Ser Val 115 120 125 Gly Val Asn Val Phe Ser Gly Ala Ala Ser Gly Ile Ile Gly Ala Val 130 135 140 Ile Gly Ser Pro Leu Phe Leu Val Lys Thr Arg Leu Gln Ser Tyr Ser 145 150 155 160 Glu Phe Ile Lys Ile Gly Glu Gln Thr His Tyr Thr Gly Val Trp Asn 165 170 175 Gly Leu Val Thr Ile Phe Lys Thr Glu Gly Val Lys Gly Leu Phe Arg 180 185 190 Gly Ile Asp Ala Ala Ile Leu Arg Thr Gly Ala Gly Ser Ser Val Gln 195 200 205 Leu Pro Ile Tyr Asn Thr Ala Lys Asn Ile Leu Val Lys Asn Asp Leu 210 215 220 Met Lys Asp Gly Pro Ala Leu His Leu Thr Ala Ser Thr Ile Ser Gly 225 230 235 240 Leu Gly Val Ala Val Val Met Asn Pro Trp Asp Val Ile Leu Thr Arg 245 250 255 Ile Tyr Asn Gln Lys Gly Asp Leu Tyr Lys Gly Pro Ile Asp Cys Leu 260 265 270 Val Lys Thr Val Arg Ile Glu Gly Val Thr Ala Leu Tyr Lys Gly Phe 275 280 285 Ala Ala Gln Val Phe Arg Ile Ala Pro His Thr Ile Met Cys Leu Thr 290 295 300 Phe Met Glu Gln Thr Met Lys Leu Val Tyr Ser Ile Glu Ser Arg Val 305 310 315 320 Leu Gly His Asn <210> 84 <211> 1062 <212> DNA <213> Saccharomyces cerevisiae <220> Page 128 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <221> CDS <222> (1)..(1062) <400> 84 atg tcg aca gca cag aaa gct aag ata ttg caa ctc atc gat tcc tgc 48 Met Ser Thr Ala Gln Lys Ala Lys Ile Leu Gln Leu Ile Asp Ser Cys 1 5 10 15 tgc caa aat gca aaa agc aca caa ctg aaa tct tta tca ttt gtt att 96 Cys Gln Asn Ala Lys Ser Thr Gln Leu Lys Ser Leu Ser Phe Val Ile 20 25 30 gga gca gta aat ggc acg acg aaa gaa gct aaa aga acc tac att caa 144 Gly Ala Val Asn Gly Thr Thr Lys Glu Ala Lys Arg Thr Tyr Ile Gln 35 40 45 gaa cag tgt gaa ttt ttg gag aag tta cga caa caa aag ata aga gag 192 Glu Gln Cys Glu Phe Leu Glu Lys Leu Arg Gln Gln Lys Ile Arg Glu 50 55 60 gga aga att aac ata ttg tct atg gat gct ggt gtt tct aac ttt gct 240 Gly Arg Ile Asn Ile Leu Ser Met Asp Ala Gly Val Ser Asn Phe Ala 65 70 75 80 ttc tct aag atg caa ttg ctc aat aat gat ccg ctc cct aaa gta cta 288 Phe Ser Lys Met Gln Leu Leu Asn Asn Asp Pro Leu Pro Lys Val Leu 85 90 95 gac tgg caa aag ata aat cta gag gag aaa ttt ttt caa aac ctc aaa 336 Asp Trp Gln Lys Ile Asn Leu Glu Glu Lys Phe Phe Gln Asn Leu Lys 100 105 110 aag tta agc ttg aat cct gct gaa act tct gag ctt gta ttt aac ctt 384 Lys Leu Ser Leu Asn Pro Ala Glu Thr Ser Glu Leu Val Phe Asn Leu 115 120 125 acg gag tat tta ttt gaa tct atg ccg ata cca gat atg ttt aca att 432 Thr Glu Tyr Leu Phe Glu Ser Met Pro Ile Pro Asp Met Phe Thr Ile 130 135 140 gaa agg caa cgt acc aga act atg tct tcg agg cat att tta gac cca 480 Glu Arg Gln Arg Thr Arg Thr Met Ser Ser Arg His Ile Leu Asp Pro 145 150 155 160 att tta aaa gtg aat att ctc gaa cag att ctt ttc tct aac ttg gaa 528 Ile Leu Lys Val Asn Ile Leu Glu Gln Ile Leu Phe Ser Asn Leu Glu 165 170 175 aat aaa atg aag tat acg aat aaa ata ccg aat acg tcc aag ttg agg 576 Asn Lys Met Lys Tyr Thr Asn Lys Ile Pro Asn Thr Ser Lys Leu Arg 180 185 190 tat atg gta tgt tcg tcc gat cca cat cgg atg act tca tat tgg tgc 624 Tyr Met Val Cys Ser Ser Asp Pro His Arg Met Thr Ser Tyr Trp Cys 195 200 205 att cca aga gaa gag aca ccg acc agt tca aaa aag tta aaa tct aac 672 Ile Pro Arg Glu Glu Thr Pro Thr Ser Ser Lys Lys Leu Lys Ser Asn 210 215 220 aaa cat agc aaa gat tct cga ata aag cta gtg aaa aaa ata ctt tca 720 Lys His Ser Lys Asp Ser Arg Ile Lys Leu Val Lys Lys Ile Leu Ser 225 230 235 240 acc tca ata cta gaa ggt aat tca act agt tct aca aaa ctg gtc gag 768 Thr Ser Ile Leu Glu Gly Asn Ser Thr Ser Ser Thr Lys Leu Val Glu 245 250 255 Page 129 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttc ata gga gtt tgg aat aat agg ata aga aat gcc ctt acc aaa aaa 816 Phe Ile Gly Val Trp Asn Asn Arg Ile Arg Asn Ala Leu Thr Lys Lys 260 265 270 aaa agt ttc aag cta tgt gat ata cta gag atc caa gat aat tcg ggg 864 Lys Ser Phe Lys Leu Cys Asp Ile Leu Glu Ile Gln Asp Asn Ser Gly 275 280 285 gtg aga aaa gat gac gat ttg gca gat tca ttc ctc cat tgt ttg tct 912 Val Arg Lys Asp Asp Asp Leu Ala Asp Ser Phe Leu His Cys Leu Ser 290 295 300 tgg atg gag tgg tta aaa aat tat gaa agt att act gaa ctc ttg aat 960 Trp Met Glu Trp Leu Lys Asn Tyr Glu Ser Ile Thr Glu Leu Leu Asn 305 310 315 320 tca aaa aca ctg gtt aaa aca cag ttc gga cag gtg ttt gaa ttt tgt 1008 Ser Lys Thr Leu Val Lys Thr Gln Phe Gly Gln Val Phe Glu Phe Cys 325 330 335 gaa aat aag gta caa aag ctg aaa ttt ttg cag aac act tac aac aat 1056 Glu Asn Lys Val Gln Lys Leu Lys Phe Leu Gln Asn Thr Tyr Asn Asn 340 345 350 gac taa 1062 Asp <210> 85 <211> 353 <212> PRT <213> Saccharomyces cerevisiae <400> 85 Met Ser Thr Ala Gln Lys Ala Lys Ile Leu Gln Leu Ile Asp Ser Cys 1 5 10 15 Cys Gln Asn Ala Lys Ser Thr Gln Leu Lys Ser Leu Ser Phe Val Ile 20 25 30 Gly Ala Val Asn Gly Thr Thr Lys Glu Ala Lys Arg Thr Tyr Ile Gln 35 40 45 Glu Gln Cys Glu Phe Leu Glu Lys Leu Arg Gln Gln Lys Ile Arg Glu 50 55 60 Gly Arg Ile Asn Ile Leu Ser Met Asp Ala Gly Val Ser Asn Phe Ala 65 70 75 80 Phe Ser Lys Met Gln Leu Leu Asn Asn Asp Pro Leu Pro Lys Val Leu 85 90 95 Asp Trp Gln Lys Ile Asn Leu Glu Glu Lys Phe Phe Gln Asn Leu Lys 100 105 110 Lys Leu Ser Leu Asn Pro Ala Glu Thr Ser Glu Leu Val Phe Asn Leu 115 120 125 Page 130 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Glu Tyr Leu Phe Glu Ser Met Pro Ile Pro Asp Met Phe Thr Ile 130 135 140 Glu Arg Gln Arg Thr Arg Thr Met Ser Ser Arg His Ile Leu Asp Pro 145 150 155 160 Ile Leu Lys Val Asn Ile Leu Glu Gln Ile Leu Phe Ser Asn Leu Glu 165 170 175 Asn Lys Met Lys Tyr Thr Asn Lys Ile Pro Asn Thr Ser Lys Leu Arg 180 185 190 Tyr Met Val Cys Ser Ser Asp Pro His Arg Met Thr Ser Tyr Trp Cys 195 200 205 Ile Pro Arg Glu Glu Thr Pro Thr Ser Ser Lys Lys Leu Lys Ser Asn 210 215 220 Lys His Ser Lys Asp Ser Arg Ile Lys Leu Val Lys Lys Ile Leu Ser 225 230 235 240 Thr Ser Ile Leu Glu Gly Asn Ser Thr Ser Ser Thr Lys Leu Val Glu 245 250 255 Phe Ile Gly Val Trp Asn Asn Arg Ile Arg Asn Ala Leu Thr Lys Lys 260 265 270 Lys Ser Phe Lys Leu Cys Asp Ile Leu Glu Ile Gln Asp Asn Ser Gly 275 280 285 Val Arg Lys Asp Asp Asp Leu Ala Asp Ser Phe Leu His Cys Leu Ser 290 295 300 Trp Met Glu Trp Leu Lys Asn Tyr Glu Ser Ile Thr Glu Leu Leu Asn 305 310 315 320 Ser Lys Thr Leu Val Lys Thr Gln Phe Gly Gln Val Phe Glu Phe Cys 325 330 335 Glu Asn Lys Val Gln Lys Leu Lys Phe Leu Gln Asn Thr Tyr Asn Asn 340 345 350 Asp <210> 86 <211> 2052 <212> DNA <213> Saccharomyces cerevisiae <220> Page 131 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <221> CDS <222> (1)..(2052) <400> 86 atg aac aaa gaa ttg gct tct aag ttt tta tca agc atc aag cat gaa 48 Met Asn Lys Glu Leu Ala Ser Lys Phe Leu Ser Ser Ile Lys His Glu 1 5 10 15 cgt gaa caa gac att caa aca act tct agg cta tta aca acg cta tct 96 Arg Glu Gln Asp Ile Gln Thr Thr Ser Arg Leu Leu Thr Thr Leu Ser 20 25 30 atc caa caa ttg gtg caa aat ggc ttg gca ata aac aac ata cat cta 144 Ile Gln Gln Leu Val Gln Asn Gly Leu Ala Ile Asn Asn Ile His Leu 35 40 45 gaa aac ata aga tcc ggt ctc att ggc aaa tta tat atg gaa ctg gga 192 Glu Asn Ile Arg Ser Gly Leu Ile Gly Lys Leu Tyr Met Glu Leu Gly 50 55 60 cct aac ttg gcg gtt aac gac aaa att caa agg ggt gat att aag gtt 240 Pro Asn Leu Ala Val Asn Asp Lys Ile Gln Arg Gly Asp Ile Lys Val 65 70 75 80 ggt gat att gtt ttg gta cgc cct gca aaa acc aaa gta aat acc aag 288 Gly Asp Ile Val Leu Val Arg Pro Ala Lys Thr Lys Val Asn Thr Lys 85 90 95 act aag ccc aaa gtc aaa aag gtg tct gaa gac tcc aat ggc gag caa 336 Thr Lys Pro Lys Val Lys Lys Val Ser Glu Asp Ser Asn Gly Glu Gln 100 105 110 gcg gaa tgc tca ggc gtt gtc tac aaa atg agt gat act caa atc acc 384 Ala Glu Cys Ser Gly Val Val Tyr Lys Met Ser Asp Thr Gln Ile Thr 115 120 125 ata gct cta gaa gaa tct caa gat gtt att gct acc aca ttt tat tct 432 Ile Ala Leu Glu Glu Ser Gln Asp Val Ile Ala Thr Thr Phe Tyr Ser 130 135 140 tat agc aaa ctt tac att tta aag act acc aat gtc gtc acg tat aat 480 Tyr Ser Lys Leu Tyr Ile Leu Lys Thr Thr Asn Val Val Thr Tyr Asn 145 150 155 160 aga atg gaa tcc aca atg aga aaa ctg tct gaa att agt tca ccc ata 528 Arg Met Glu Ser Thr Met Arg Lys Leu Ser Glu Ile Ser Ser Pro Ile 165 170 175 caa gac aaa att ata caa tac ttg gta aac gaa cgc ccc ttc atc ccc 576 Gln Asp Lys Ile Ile Gln Tyr Leu Val Asn Glu Arg Pro Phe Ile Pro 180 185 190 aat aca aac agc ttt caa aac att aaa tct ttt tta aac ccg aat ctg 624 Asn Thr Asn Ser Phe Gln Asn Ile Lys Ser Phe Leu Asn Pro Asn Leu 195 200 205 aat gac tcc cag aaa act gcc att aat ttt gcc att aac aat gac ttg 672 Asn Asp Ser Gln Lys Thr Ala Ile Asn Phe Ala Ile Asn Asn Asp Leu 210 215 220 acc att ata cat ggt cct cct ggt acg ggt aaa aca ttc aca tta att 720 Thr Ile Ile His Gly Pro Pro Gly Thr Gly Lys Thr Phe Thr Leu Ile 225 230 235 240 gaa ttg atc cag caa ttg cta att aaa aat cct gag gag aga atc tta 768 Glu Leu Ile Gln Gln Leu Leu Ile Lys Asn Pro Glu Glu Arg Ile Leu 245 250 255 Page 132 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt att tgt ggg cct tcc aat att tct gtg gat acg att ctg gag agg cta 816 Ile Cys Gly Pro Ser Asn Ile Ser Val Asp Thr Ile Leu Glu Arg Leu 260 265 270 acg cct ctt gtg ccg aat aat tta tta tta aga atc ggt cat cct gct 864 Thr Pro Leu Val Pro Asn Asn Leu Leu Leu Arg Ile Gly His Pro Ala 275 280 285 agg cta tta gac tct aat aaa aga cac tct ctt gat ata ctt agt aaa 912 Arg Leu Leu Asp Ser Asn Lys Arg His Ser Leu Asp Ile Leu Ser Lys 290 295 300 aag aat act att gtg aag gac att tcc cag gag att gac aaa tta att 960 Lys Asn Thr Ile Val Lys Asp Ile Ser Gln Glu Ile Asp Lys Leu Ile 305 310 315 320 cag gag aat aaa aaa cta aaa aac tat aag caa cgt aaa gaa aac tgg 1008 Gln Glu Asn Lys Lys Leu Lys Asn Tyr Lys Gln Arg Lys Glu Asn Trp 325 330 335 aac gaa att aaa ctg ctg cgc aaa gat tta aag aaa aga gag ttc aaa 1056 Asn Glu Ile Lys Leu Leu Arg Lys Asp Leu Lys Lys Arg Glu Phe Lys 340 345 350 acc att aag gac tta ata ata caa tcg aga ata gtc gtc acc act tta 1104 Thr Ile Lys Asp Leu Ile Ile Gln Ser Arg Ile Val Val Thr Thr Leu 355 360 365 cac ggt tca tca tcg aga gaa cta tgc tcc ctt tat aga gat gat cca 1152 His Gly Ser Ser Ser Arg Glu Leu Cys Ser Leu Tyr Arg Asp Asp Pro 370 375 380 aat ttc cag ctt ttc gat acc ttg atc atc gat gaa gtc tca cag gcc 1200 Asn Phe Gln Leu Phe Asp Thr Leu Ile Ile Asp Glu Val Ser Gln Ala 385 390 395 400 atg gaa cca caa tgc tgg atc cca cta att gca cat caa aat cag ttc 1248 Met Glu Pro Gln Cys Trp Ile Pro Leu Ile Ala His Gln Asn Gln Phe 405 410 415 cac aaa cta gtc ctt gct ggt gac aat aaa caa ttg cca ccc aca atc 1296 His Lys Leu Val Leu Ala Gly Asp Asn Lys Gln Leu Pro Pro Thr Ile 420 425 430 aaa aca gaa gac gac aaa aat gtc att cac aat ttg gaa acc aca cta 1344 Lys Thr Glu Asp Asp Lys Asn Val Ile His Asn Leu Glu Thr Thr Leu 435 440 445 ttt gac aga ata atc aaa ata ttc ccg aaa agg gat atg gta aaa ttt 1392 Phe Asp Arg Ile Ile Lys Ile Phe Pro Lys Arg Asp Met Val Lys Phe 450 455 460 ctt aac gtt caa tac agg atg aat caa aaa att atg gaa ttt cca tcg 1440 Leu Asn Val Gln Tyr Arg Met Asn Gln Lys Ile Met Glu Phe Pro Ser 465 470 475 480 cac tca atg tat aat ggg aaa cta ttg gcc gat gca acg gtc gcg aac 1488 His Ser Met Tyr Asn Gly Lys Leu Leu Ala Asp Ala Thr Val Ala Asn 485 490 495 aga ctt ttg ata gac cta ccg acc gtc gat gct acg cca tct gag gat 1536 Arg Leu Leu Ile Asp Leu Pro Thr Val Asp Ala Thr Pro Ser Glu Asp 500 505 510 gat gac gat aca aaa att cct tta att tgg tat gat acg caa ggt gat 1584 Asp Asp Asp Thr Lys Ile Pro Leu Ile Trp Tyr Asp Thr Gln Gly Asp 515 520 525 Page 133 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa ttt caa gag act gca gat gaa gct act atc ctt gga tct aag tat 1632 Glu Phe Gln Glu Thr Ala Asp Glu Ala Thr Ile Leu Gly Ser Lys Tyr 530 535 540 aat gag ggc gaa att gcc att gta aaa gaa cac att gag aat tta agg 1680 Asn Glu Gly Glu Ile Ala Ile Val Lys Glu His Ile Glu Asn Leu Arg 545 550 555 560 tca ttc aac gtc ccg gag aac tct ata ggt gtt att tct cca tac aat 1728 Ser Phe Asn Val Pro Glu Asn Ser Ile Gly Val Ile Ser Pro Tyr Asn 565 570 575 gca caa gtt tct cat ctg aaa aaa ttg atc cat gat gaa tta aaa tta 1776 Ala Gln Val Ser His Leu Lys Lys Leu Ile His Asp Glu Leu Lys Leu 580 585 590 act gat att gaa ata tca act gta gat ggg ttc cag ggc cgt gaa aaa 1824 Thr Asp Ile Glu Ile Ser Thr Val Asp Gly Phe Gln Gly Arg Glu Lys 595 600 605 gat gtt atc ata ttg agt tta gtt cgt agc aat gaa aaa ttt gaa gtt 1872 Asp Val Ile Ile Leu Ser Leu Val Arg Ser Asn Glu Lys Phe Glu Val 610 615 620 ggt ttc ctt aag gaa gaa cga aga ctg aac gtc gcc atg aca aga ccc 1920 Gly Phe Leu Lys Glu Glu Arg Arg Leu Asn Val Ala Met Thr Arg Pro 625 630 635 640 aga agg caa cta gtt gtt gtt ggc aat ata gaa gtt ctg caa agg tgc 1968 Arg Arg Gln Leu Val Val Val Gly Asn Ile Glu Val Leu Gln Arg Cys 645 650 655 ggt aac aag tac cta aaa agt tgg tca gaa tgg tgt gaa gag aac gct 2016 Gly Asn Lys Tyr Leu Lys Ser Trp Ser Glu Trp Cys Glu Glu Asn Ala 660 665 670 gac gta agg tac ccc aac att gac gat tat ttg taa 2052 Asp Val Arg Tyr Pro Asn Ile Asp Asp Tyr Leu 675 680 <210> 87 <211> 683 <212> PRT <213> Saccharomyces cerevisiae <400> 87 Met Asn Lys Glu Leu Ala Ser Lys Phe Leu Ser Ser Ile Lys His Glu 1 5 10 15 Arg Glu Gln Asp Ile Gln Thr Thr Ser Arg Leu Leu Thr Thr Leu Ser 20 25 30 Ile Gln Gln Leu Val Gln Asn Gly Leu Ala Ile Asn Asn Ile His Leu 35 40 45 Glu Asn Ile Arg Ser Gly Leu Ile Gly Lys Leu Tyr Met Glu Leu Gly 50 55 60 Pro Asn Leu Ala Val Asn Asp Lys Ile Gln Arg Gly Asp Ile Lys Val 65 70 75 80 Page 134 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Asp Ile Val Leu Val Arg Pro Ala Lys Thr Lys Val Asn Thr Lys 85 90 95 Thr Lys Pro Lys Val Lys Lys Val Ser Glu Asp Ser Asn Gly Glu Gln 100 105 110 Ala Glu Cys Ser Gly Val Val Tyr Lys Met Ser Asp Thr Gln Ile Thr 115 120 125 Ile Ala Leu Glu Glu Ser Gln Asp Val Ile Ala Thr Thr Phe Tyr Ser 130 135 140 Tyr Ser Lys Leu Tyr Ile Leu Lys Thr Thr Asn Val Val Thr Tyr Asn 145 150 155 160 Arg Met Glu Ser Thr Met Arg Lys Leu Ser Glu Ile Ser Ser Pro Ile 165 170 175 Gln Asp Lys Ile Ile Gln Tyr Leu Val Asn Glu Arg Pro Phe Ile Pro 180 185 190 Asn Thr Asn Ser Phe Gln Asn Ile Lys Ser Phe Leu Asn Pro Asn Leu 195 200 205 Asn Asp Ser Gln Lys Thr Ala Ile Asn Phe Ala Ile Asn Asn Asp Leu 210 215 220 Thr Ile Ile His Gly Pro Pro Gly Thr Gly Lys Thr Phe Thr Leu Ile 225 230 235 240 Glu Leu Ile Gln Gln Leu Leu Ile Lys Asn Pro Glu Glu Arg Ile Leu 245 250 255 Ile Cys Gly Pro Ser Asn Ile Ser Val Asp Thr Ile Leu Glu Arg Leu 260 265 270 Thr Pro Leu Val Pro Asn Asn Leu Leu Leu Arg Ile Gly His Pro Ala 275 280 285 Arg Leu Leu Asp Ser Asn Lys Arg His Ser Leu Asp Ile Leu Ser Lys 290 295 300 Lys Asn Thr Ile Val Lys Asp Ile Ser Gln Glu Ile Asp Lys Leu Ile 305 310 315 320 Gln Glu Asn Lys Lys Leu Lys Asn Tyr Lys Gln Arg Lys Glu Asn Trp 325 330 335 Asn Glu Ile Lys Leu Leu Arg Lys Asp Leu Lys Lys Arg Glu Phe Lys 340 345 350 Page 135 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Ile Lys Asp Leu Ile Ile Gln Ser Arg Ile Val Val Thr Thr Leu 355 360 365 His Gly Ser Ser Ser Arg Glu Leu Cys Ser Leu Tyr Arg Asp Asp Pro 370 375 380 Asn Phe Gln Leu Phe Asp Thr Leu Ile Ile Asp Glu Val Ser Gln Ala 385 390 395 400 Met Glu Pro Gln Cys Trp Ile Pro Leu Ile Ala His Gln Asn Gln Phe 405 410 415 His Lys Leu Val Leu Ala Gly Asp Asn Lys Gln Leu Pro Pro Thr Ile 420 425 430 Lys Thr Glu Asp Asp Lys Asn Val Ile His Asn Leu Glu Thr Thr Leu 435 440 445 Phe Asp Arg Ile Ile Lys Ile Phe Pro Lys Arg Asp Met Val Lys Phe 450 455 460 Leu Asn Val Gln Tyr Arg Met Asn Gln Lys Ile Met Glu Phe Pro Ser 465 470 475 480 His Ser Met Tyr Asn Gly Lys Leu Leu Ala Asp Ala Thr Val Ala Asn 485 490 495 Arg Leu Leu Ile Asp Leu Pro Thr Val Asp Ala Thr Pro Ser Glu Asp 500 505 510 Asp Asp Asp Thr Lys Ile Pro Leu Ile Trp Tyr Asp Thr Gln Gly Asp 515 520 525 Glu Phe Gln Glu Thr Ala Asp Glu Ala Thr Ile Leu Gly Ser Lys Tyr 530 535 540 Asn Glu Gly Glu Ile Ala Ile Val Lys Glu His Ile Glu Asn Leu Arg 545 550 555 560 Ser Phe Asn Val Pro Glu Asn Ser Ile Gly Val Ile Ser Pro Tyr Asn 565 570 575 Ala Gln Val Ser His Leu Lys Lys Leu Ile His Asp Glu Leu Lys Leu 580 585 590 Thr Asp Ile Glu Ile Ser Thr Val Asp Gly Phe Gln Gly Arg Glu Lys 595 600 605 Asp Val Ile Ile Leu Ser Leu Val Arg Ser Asn Glu Lys Phe Glu Val 610 615 620 Page 136 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Phe Leu Lys Glu Glu Arg Arg Leu Asn Val Ala Met Thr Arg Pro 625 630 635 640 Arg Arg Gln Leu Val Val Val Gly Asn Ile Glu Val Leu Gln Arg Cys 645 650 655 Gly Asn Lys Tyr Leu Lys Ser Trp Ser Glu Trp Cys Glu Glu Asn Ala 660 665 670 Asp Val Arg Tyr Pro Asn Ile Asp Asp Tyr Leu 675 680 <210> 88 <211> 414 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(414) <400> 88 atg gaa act gaa gta cct gca cca gtg cga act cat tca tat gcc tta 48 Met Glu Thr Glu Val Pro Ala Pro Val Arg Thr His Ser Tyr Ala Leu 1 5 10 15 gac aga tat gtt aga cag aaa agg agg gaa aaa caa aga aag cag agc 96 Asp Arg Tyr Val Arg Gln Lys Arg Arg Glu Lys Gln Arg Lys Gln Ser 20 25 30 tta aag cgc gtc gaa aag aaa tat act cct agt gaa tta gct ctg tac 144 Leu Lys Arg Val Glu Lys Lys Tyr Thr Pro Ser Glu Leu Ala Leu Tyr 35 40 45 gaa att cga aaa tac caa cgt tcc acg gat tta tta atc tcc aaa att 192 Glu Ile Arg Lys Tyr Gln Arg Ser Thr Asp Leu Leu Ile Ser Lys Ile 50 55 60 cca ttt gca agg cta gtg aaa gaa gtt aca gac gag ttt aca act aaa 240 Pro Phe Ala Arg Leu Val Lys Glu Val Thr Asp Glu Phe Thr Thr Lys 65 70 75 80 gat cag gat tta cgt tgg cag tca atg gcg att atg gcg tta cag gaa 288 Asp Gln Asp Leu Arg Trp Gln Ser Met Ala Ile Met Ala Leu Gln Glu 85 90 95 gca agc gaa gcg tat ctg gta gga tta ttg gaa cat aca aac ctc ttg 336 Ala Ser Glu Ala Tyr Leu Val Gly Leu Leu Glu His Thr Asn Leu Leu 100 105 110 gcg ctg cat gca aaa aga att act ata atg aag aaa gac atg caa cta 384 Ala Leu His Ala Lys Arg Ile Thr Ile Met Lys Lys Asp Met Gln Leu 115 120 125 gca aga aga atc agg gga cag ttt att tag 414 Ala Arg Arg Ile Arg Gly Gln Phe Ile 130 135 <210> 89 <211> 137 Page 137 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> PRT <213> Saccharomyces cerevisiae <400> 89 Met Glu Thr Glu Val Pro Ala Pro Val Arg Thr His Ser Tyr Ala Leu 1 5 10 15 Asp Arg Tyr Val Arg Gln Lys Arg Arg Glu Lys Gln Arg Lys Gln Ser 20 25 30 Leu Lys Arg Val Glu Lys Lys Tyr Thr Pro Ser Glu Leu Ala Leu Tyr 35 40 45 Glu Ile Arg Lys Tyr Gln Arg Ser Thr Asp Leu Leu Ile Ser Lys Ile 50 55 60 Pro Phe Ala Arg Leu Val Lys Glu Val Thr Asp Glu Phe Thr Thr Lys 65 70 75 80 Asp Gln Asp Leu Arg Trp Gln Ser Met Ala Ile Met Ala Leu Gln Glu 85 90 95 Ala Ser Glu Ala Tyr Leu Val Gly Leu Leu Glu His Thr Asn Leu Leu 100 105 110 Ala Leu His Ala Lys Arg Ile Thr Ile Met Lys Lys Asp Met Gln Leu 115 120 125 Ala Arg Arg Ile Arg Gly Gln Phe Ile 130 135 <210> 90 <211> 1293 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1293) <400> 90 atg gat gat ata agc gga agg caa act tta cct cga ata aac cgt ttg 48 Met Asp Asp Ile Ser Gly Arg Gln Thr Leu Pro Arg Ile Asn Arg Leu 1 5 10 15 ttg gag cac gtg gga aat ccc caa gat agt ttg tca atc cta cat ata 96 Leu Glu His Val Gly Asn Pro Gln Asp Ser Leu Ser Ile Leu His Ile 20 25 30 gcg gga aca aat ggt aag gag aca gta tct aaa ttt ttg aca tcc ata 144 Ala Gly Thr Asn Gly Lys Glu Thr Val Ser Lys Phe Leu Thr Ser Ile 35 40 45 ttg cag cat ccg ggg caa cag cgg caa agg gtc ttg att ggt agg tat 192 Leu Gln His Pro Gly Gln Gln Arg Gln Arg Val Leu Ile Gly Arg Tyr 50 55 60 Page 138 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt act aca tct tcc ttg cta aac gcc aaa gaa gag gat att agc att aat 240 Thr Thr Ser Ser Leu Leu Asn Ala Lys Glu Glu Asp Ile Ser Ile Asn 65 70 75 80 aat gaa gcc att tcc ttg ata gag tat tct agg atc gag aag gaa ctt 288 Asn Glu Ala Ile Ser Leu Ile Glu Tyr Ser Arg Ile Glu Lys Glu Leu 85 90 95 ata gaa gca gat agt tct ttg aaa tta cag tgc aac aac ctc gaa ctg 336 Ile Glu Ala Asp Ser Ser Leu Lys Leu Gln Cys Asn Asn Leu Glu Leu 100 105 110 cta aca agc gta gct ctc gta tac ttc gct aag aaa aat tgc caa tgg 384 Leu Thr Ser Val Ala Leu Val Tyr Phe Ala Lys Lys Asn Cys Gln Trp 115 120 125 tgc ata ata gaa act ggt tta gct gga aaa cag gac cct gga agt ata 432 Cys Ile Ile Glu Thr Gly Leu Ala Gly Lys Gln Asp Pro Gly Ser Ile 130 135 140 att gct ggt caa agt aga gtc tgt tgc gcc att act aac gtg ggc att 480 Ile Ala Gly Gln Ser Arg Val Cys Cys Ala Ile Thr Asn Val Gly Ile 145 150 155 160 agc gat gaa gct ttt tta tgc aag ttt ttg tct caa att act gaa agt 528 Ser Asp Glu Ala Phe Leu Cys Lys Phe Leu Ser Gln Ile Thr Glu Ser 165 170 175 tcc aca aat aaa gca att ttt cta tta gac ggt tct aat gac gaa ttt 576 Ser Thr Asn Lys Ala Ile Phe Leu Leu Asp Gly Ser Asn Asp Glu Phe 180 185 190 gta cga aat acg ata acg aaa cgg tgc cat gat gtt gga tgt cca tta 624 Val Arg Asn Thr Ile Thr Lys Arg Cys His Asp Val Gly Cys Pro Leu 195 200 205 gaa atc acc gac cct tct ctt agg gat tac aat gta cac aca gac aca 672 Glu Ile Thr Asp Pro Ser Leu Arg Asp Tyr Asn Val His Thr Asp Thr 210 215 220 tgg ggc act ctt gaa gtt cgc ctg cca tac agt gaa gaa gaa tat caa 720 Trp Gly Thr Leu Glu Val Arg Leu Pro Tyr Ser Glu Glu Glu Tyr Gln 225 230 235 240 ata ttt aat ttg aga gtt gcg ata gcg gtt tta gac ttt ttg agc aag 768 Ile Phe Asn Leu Arg Val Ala Ile Ala Val Leu Asp Phe Leu Ser Lys 245 250 255 gaa aaa aag gtt tgt att tca aag gat caa cta tcc caa ggt tta ata 816 Glu Lys Lys Val Cys Ile Ser Lys Asp Gln Leu Ser Gln Gly Leu Ile 260 265 270 tct gtg gat tgg cca aga agt tta cat cgc ttg gat tac tgt tat gaa 864 Ser Val Asp Trp Pro Arg Ser Leu His Arg Leu Asp Tyr Cys Tyr Glu 275 280 285 tct act agt gga aag aaa atc gca tta cta tta gac aac gca aat aat 912 Ser Thr Ser Gly Lys Lys Ile Ala Leu Leu Leu Asp Asn Ala Asn Asn 290 295 300 gcg aag gca gct cga aat tta gcc tgc cat tta agg acc acg tac ggt 960 Ala Lys Ala Ala Arg Asn Leu Ala Cys His Leu Arg Thr Thr Tyr Gly 305 310 315 320 gat acg cca tta aca ttt gtc att gct ata aca act ggg aaa aag gtg 1008 Asp Thr Pro Leu Thr Phe Val Ile Ala Ile Thr Thr Gly Lys Lys Val 325 330 335 Page 139 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tct ccc tta ctt gat ccg cta ata cgt cca caa gat tat gtt att gtg 1056 Ser Pro Leu Leu Asp Pro Leu Ile Arg Pro Gln Asp Tyr Val Ile Val 340 345 350 act aga ttt ggg tca gtg gtt gga atg ccg tgg atc caa tcc cta gaa 1104 Thr Arg Phe Gly Ser Val Val Gly Met Pro Trp Ile Gln Ser Leu Glu 355 360 365 ccg gtg aat ctt ctc gca ttt atc aaa aac cgg tat acg aga aat gtt 1152 Pro Val Asn Leu Leu Ala Phe Ile Lys Asn Arg Tyr Thr Arg Asn Val 370 375 380 aac atg cag ccg gat ctt caa agt gtc tgg acc ttc ctt gaa aca agt 1200 Asn Met Gln Pro Asp Leu Gln Ser Val Trp Thr Phe Leu Glu Thr Ser 385 390 395 400 ggg tta aag acg att gtt cct gtt atc gta tgt gga tca ctg tat atc 1248 Gly Leu Lys Thr Ile Val Pro Val Ile Val Cys Gly Ser Leu Tyr Ile 405 410 415 tgc aaa gag cta ttg cgc tta cac aac tgt cac ttg cca gta tag 1293 Cys Lys Glu Leu Leu Arg Leu His Asn Cys His Leu Pro Val 420 425 430 <210> 91 <211> 430 <212> PRT <213> Saccharomyces cerevisiae <400> 91 Met Asp Asp Ile Ser Gly Arg Gln Thr Leu Pro Arg Ile Asn Arg Leu 1 5 10 15 Leu Glu His Val Gly Asn Pro Gln Asp Ser Leu Ser Ile Leu His Ile 20 25 30 Ala Gly Thr Asn Gly Lys Glu Thr Val Ser Lys Phe Leu Thr Ser Ile 35 40 45 Leu Gln His Pro Gly Gln Gln Arg Gln Arg Val Leu Ile Gly Arg Tyr 50 55 60 Thr Thr Ser Ser Leu Leu Asn Ala Lys Glu Glu Asp Ile Ser Ile Asn 65 70 75 80 Asn Glu Ala Ile Ser Leu Ile Glu Tyr Ser Arg Ile Glu Lys Glu Leu 85 90 95 Ile Glu Ala Asp Ser Ser Leu Lys Leu Gln Cys Asn Asn Leu Glu Leu 100 105 110 Leu Thr Ser Val Ala Leu Val Tyr Phe Ala Lys Lys Asn Cys Gln Trp 115 120 125 Cys Ile Ile Glu Thr Gly Leu Ala Gly Lys Gln Asp Pro Gly Ser Ile 130 135 140 Page 140 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Ala Gly Gln Ser Arg Val Cys Cys Ala Ile Thr Asn Val Gly Ile 145 150 155 160 Ser Asp Glu Ala Phe Leu Cys Lys Phe Leu Ser Gln Ile Thr Glu Ser 165 170 175 Ser Thr Asn Lys Ala Ile Phe Leu Leu Asp Gly Ser Asn Asp Glu Phe 180 185 190 Val Arg Asn Thr Ile Thr Lys Arg Cys His Asp Val Gly Cys Pro Leu 195 200 205 Glu Ile Thr Asp Pro Ser Leu Arg Asp Tyr Asn Val His Thr Asp Thr 210 215 220 Trp Gly Thr Leu Glu Val Arg Leu Pro Tyr Ser Glu Glu Glu Tyr Gln 225 230 235 240 Ile Phe Asn Leu Arg Val Ala Ile Ala Val Leu Asp Phe Leu Ser Lys 245 250 255 Glu Lys Lys Val Cys Ile Ser Lys Asp Gln Leu Ser Gln Gly Leu Ile 260 265 270 Ser Val Asp Trp Pro Arg Ser Leu His Arg Leu Asp Tyr Cys Tyr Glu 275 280 285 Ser Thr Ser Gly Lys Lys Ile Ala Leu Leu Leu Asp Asn Ala Asn Asn 290 295 300 Ala Lys Ala Ala Arg Asn Leu Ala Cys His Leu Arg Thr Thr Tyr Gly 305 310 315 320 Asp Thr Pro Leu Thr Phe Val Ile Ala Ile Thr Thr Gly Lys Lys Val 325 330 335 Ser Pro Leu Leu Asp Pro Leu Ile Arg Pro Gln Asp Tyr Val Ile Val 340 345 350 Thr Arg Phe Gly Ser Val Val Gly Met Pro Trp Ile Gln Ser Leu Glu 355 360 365 Pro Val Asn Leu Leu Ala Phe Ile Lys Asn Arg Tyr Thr Arg Asn Val 370 375 380 Asn Met Gln Pro Asp Leu Gln Ser Val Trp Thr Phe Leu Glu Thr Ser 385 390 395 400 Gly Leu Lys Thr Ile Val Pro Val Ile Val Cys Gly Ser Leu Tyr Ile 405 410 415 Page 141 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Cys Lys Glu Leu Leu Arg Leu His Asn Cys His Leu Pro Val 420 425 430 <210> 92 <211> 693 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(693) <400> 92 atg cct gtc cca tct gtt act gtc act acc gat aat gaa tat gaa gac 48 Met Pro Val Pro Ser Val Thr Val Thr Thr Asp Asn Glu Tyr Glu Asp 1 5 10 15 ata tcg tcc ttt tct tct att gac tct tac aaa ccg gag ccc ttt act 96 Ile Ser Ser Phe Ser Ser Ile Asp Ser Tyr Lys Pro Glu Pro Phe Thr 20 25 30 ggg ttc aaa gat tct gaa gct cca gaa cag cct ctt tta aaa aac gat 144 Gly Phe Lys Asp Ser Glu Ala Pro Glu Gln Pro Leu Leu Lys Asn Asp 35 40 45 acc att gtt gga aag ggg caa ctg gaa gat gat agt aat gta gat gat 192 Thr Ile Val Gly Lys Gly Gln Leu Glu Asp Asp Ser Asn Val Asp Asp 50 55 60 caa cac cgt cat tca gat gtg cat tct cat cac agt tct agt act tta 240 Gln His Arg His Ser Asp Val His Ser His His Ser Ser Ser Thr Leu 65 70 75 80 aaa agg cca act tca aat tcg ata gaa aag atg gtt acc cac aat gct 288 Lys Arg Pro Thr Ser Asn Ser Ile Glu Lys Met Val Thr His Asn Ala 85 90 95 tta gag ggc aac tca gaa aca gtt gat tcc tta aaa gaa gat ggt tta 336 Leu Glu Gly Asn Ser Glu Thr Val Asp Ser Leu Lys Glu Asp Gly Leu 100 105 110 aat ttg aac aag aaa gct ctt ccg gat att acc gcc cca gta aca aac 384 Asn Leu Asn Lys Lys Ala Leu Pro Asp Ile Thr Ala Pro Val Thr Asn 115 120 125 tca gct cac gat gct gca ttt cca gaa gag tat cgt tta gaa act gaa 432 Ser Ala His Asp Ala Ala Phe Pro Glu Glu Tyr Arg Leu Glu Thr Glu 130 135 140 acc ggg ttg gtc aaa ttg aag acg ctt gaa agt ttg aag agg gag gac 480 Thr Gly Leu Val Lys Leu Lys Thr Leu Glu Ser Leu Lys Arg Glu Asp 145 150 155 160 tct cgc gta tcc tca act aaa aaa gag cat att aac gac cat aca gat 528 Ser Arg Val Ser Ser Thr Lys Lys Glu His Ile Asn Asp His Thr Asp 165 170 175 atg cat tcg aca cga tcc aag gtt act aca aat tct caa ggt tct tct 576 Met His Ser Thr Arg Ser Lys Val Thr Thr Asn Ser Gln Gly Ser Ser 180 185 190 cta gaa cca aac aag ttg aac atg gca gta gag aag aat aag aag agg 624 Leu Glu Pro Asn Lys Leu Asn Met Ala Val Glu Lys Asn Lys Lys Arg 195 200 205 Page 142 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atc gaa aaa tat caa aaa cat aaa tca gaa aag ggg atc aag ggg ttt 672 Ile Glu Lys Tyr Gln Lys His Lys Ser Glu Lys Gly Ile Lys Gly Phe 210 215 220 ttt cat aga att ttc gat taa 693 Phe His Arg Ile Phe Asp 225 230 <210> 93 <211> 230 <212> PRT <213> Saccharomyces cerevisiae <400> 93 Met Pro Val Pro Ser Val Thr Val Thr Thr Asp Asn Glu Tyr Glu Asp 1 5 10 15 Ile Ser Ser Phe Ser Ser Ile Asp Ser Tyr Lys Pro Glu Pro Phe Thr 20 25 30 Gly Phe Lys Asp Ser Glu Ala Pro Glu Gln Pro Leu Leu Lys Asn Asp 35 40 45 Thr Ile Val Gly Lys Gly Gln Leu Glu Asp Asp Ser Asn Val Asp Asp 50 55 60 Gln His Arg His Ser Asp Val His Ser His His Ser Ser Ser Thr Leu 65 70 75 80 Lys Arg Pro Thr Ser Asn Ser Ile Glu Lys Met Val Thr His Asn Ala 85 90 95 Leu Glu Gly Asn Ser Glu Thr Val Asp Ser Leu Lys Glu Asp Gly Leu 100 105 110 Asn Leu Asn Lys Lys Ala Leu Pro Asp Ile Thr Ala Pro Val Thr Asn 115 120 125 Ser Ala His Asp Ala Ala Phe Pro Glu Glu Tyr Arg Leu Glu Thr Glu 130 135 140 Thr Gly Leu Val Lys Leu Lys Thr Leu Glu Ser Leu Lys Arg Glu Asp 145 150 155 160 Ser Arg Val Ser Ser Thr Lys Lys Glu His Ile Asn Asp His Thr Asp 165 170 175 Met His Ser Thr Arg Ser Lys Val Thr Thr Asn Ser Gln Gly Ser Ser 180 185 190 Leu Glu Pro Asn Lys Leu Asn Met Ala Val Glu Lys Asn Lys Lys Arg 195 200 205 Page 143 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Glu Lys Tyr Gln Lys His Lys Ser Glu Lys Gly Ile Lys Gly Phe 210 215 220 Phe His Arg Ile Phe Asp 225 230 <210> 94 <211> 510 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(510) <400> 94 atg tac att cct aaa cat ttt gag tcc atg gaa ctc tca agg tac aaa 48 Met Tyr Ile Pro Lys His Phe Glu Ser Met Glu Leu Ser Arg Tyr Lys 1 5 10 15 tta tca aaa aaa ccc ccg cta gga aca cta ttc tcc tct aag gct agc 96 Leu Ser Lys Lys Pro Pro Leu Gly Thr Leu Phe Ser Ser Lys Ala Ser 20 25 30 agg caa ggt ttc ttc gga tgg aga act tct tcc aat aaa gat gac ccc 144 Arg Gln Gly Phe Phe Gly Trp Arg Thr Ser Ser Asn Lys Asp Asp Pro 35 40 45 gat ttt ggt atg tgc gca tca cat att cca ttt gta ttc gtg gag ttc 192 Asp Phe Gly Met Cys Ala Ser His Ile Pro Phe Val Phe Val Glu Phe 50 55 60 gat aat gga gag cat aaa ctt att gca cat tta gca cgg aag aat aaa 240 Asp Asn Gly Glu His Lys Leu Ile Ala His Leu Ala Arg Lys Asn Lys 65 70 75 80 cat gtg gaa atg ctg gaa aga gtt caa aaa tgc tta gtg gta ttt cag 288 His Val Glu Met Leu Glu Arg Val Gln Lys Cys Leu Val Val Phe Gln 85 90 95 agc gtc gat tca tac att tct ccg gcg tgg ttc cca atg aag aaa aag 336 Ser Val Asp Ser Tyr Ile Ser Pro Ala Trp Phe Pro Met Lys Lys Lys 100 105 110 acc cat aag ttc gta cca aca tgg gat ttt gcc gct gtg cac gtt tac 384 Thr His Lys Phe Val Pro Thr Trp Asp Phe Ala Ala Val His Val Tyr 115 120 125 ggt aca cca agg att atc cgc gac gat aaa gac tgg ctt att aat atg 432 Gly Thr Pro Arg Ile Ile Arg Asp Asp Lys Asp Trp Leu Ile Asn Met 130 135 140 tta tca act ttg act gac caa gaa gaa gag aaa aga cct gag ggg gaa 480 Leu Ser Thr Leu Thr Asp Gln Glu Glu Glu Lys Arg Pro Glu Gly Glu 145 150 155 160 aat gta cga agt aaa gtg gag cgt ttc tga 510 Asn Val Arg Ser Lys Val Glu Arg Phe 165 <210> 95 <211> 169 <212> PRT Page 144 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Saccharomyces cerevisiae <400> 95 Met Tyr Ile Pro Lys His Phe Glu Ser Met Glu Leu Ser Arg Tyr Lys 1 5 10 15 Leu Ser Lys Lys Pro Pro Leu Gly Thr Leu Phe Ser Ser Lys Ala Ser 20 25 30 Arg Gln Gly Phe Phe Gly Trp Arg Thr Ser Ser Asn Lys Asp Asp Pro 35 40 45 Asp Phe Gly Met Cys Ala Ser His Ile Pro Phe Val Phe Val Glu Phe 50 55 60 Asp Asn Gly Glu His Lys Leu Ile Ala His Leu Ala Arg Lys Asn Lys 65 70 75 80 His Val Glu Met Leu Glu Arg Val Gln Lys Cys Leu Val Val Phe Gln 85 90 95 Ser Val Asp Ser Tyr Ile Ser Pro Ala Trp Phe Pro Met Lys Lys Lys 100 105 110 Thr His Lys Phe Val Pro Thr Trp Asp Phe Ala Ala Val His Val Tyr 115 120 125 Gly Thr Pro Arg Ile Ile Arg Asp Asp Lys Asp Trp Leu Ile Asn Met 130 135 140 Leu Ser Thr Leu Thr Asp Gln Glu Glu Glu Lys Arg Pro Glu Gly Glu 145 150 155 160 Asn Val Arg Ser Lys Val Glu Arg Phe 165 <210> 96 <211> 369 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(369) <400> 96 atg gca gta ccc ggg tat tac gaa tta tat cgt aga agt act ata ggg 48 Met Ala Val Pro Gly Tyr Tyr Glu Leu Tyr Arg Arg Ser Thr Ile Gly 1 5 10 15 aat agt ttg gtg gat gct ctt gat act tta att agt gat ggg aga ata 96 Asn Ser Leu Val Asp Ala Leu Asp Thr Leu Ile Ser Asp Gly Arg Ile 20 25 30 gaa gcg tcg tta gct atg cgt gtt tta gag aca ttt gac aaa gtg gtg 144 Page 145 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Ala Ser Leu Ala Met Arg Val Leu Glu Thr Phe Asp Lys Val Val 35 40 45 gct gag act tta aaa gac aat acc caa tct aaa ttg act gtg aaa gga 192 Ala Glu Thr Leu Lys Asp Asn Thr Gln Ser Lys Leu Thr Val Lys Gly 50 55 60 aac ctg gac aca tat gga ttt tgc gat gat gtt tgg act ttt atc gta 240 Asn Leu Asp Thr Tyr Gly Phe Cys Asp Asp Val Trp Thr Phe Ile Val 65 70 75 80 aaa aat tgt cag gtt act gtt gag gac agc cac cgc gac gcc tcc cag 288 Lys Asn Cys Gln Val Thr Val Glu Asp Ser His Arg Asp Ala Ser Gln 85 90 95 aac ggg tct gga gat agc caa agt gta att tcg gtg gat aag ttg agg 336 Asn Gly Ser Gly Asp Ser Gln Ser Val Ile Ser Val Asp Lys Leu Arg 100 105 110 att gtg gca tgt aac tca aaa aag agc gag taa 369 Ile Val Ala Cys Asn Ser Lys Lys Ser Glu 115 120 <210> 97 <211> 122 <212> PRT <213> Saccharomyces cerevisiae <400> 97 Met Ala Val Pro Gly Tyr Tyr Glu Leu Tyr Arg Arg Ser Thr Ile Gly 1 5 10 15 Asn Ser Leu Val Asp Ala Leu Asp Thr Leu Ile Ser Asp Gly Arg Ile 20 25 30 Glu Ala Ser Leu Ala Met Arg Val Leu Glu Thr Phe Asp Lys Val Val 35 40 45 Ala Glu Thr Leu Lys Asp Asn Thr Gln Ser Lys Leu Thr Val Lys Gly 50 55 60 Asn Leu Asp Thr Tyr Gly Phe Cys Asp Asp Val Trp Thr Phe Ile Val 65 70 75 80 Lys Asn Cys Gln Val Thr Val Glu Asp Ser His Arg Asp Ala Ser Gln 85 90 95 Asn Gly Ser Gly Asp Ser Gln Ser Val Ile Ser Val Asp Lys Leu Arg 100 105 110 Ile Val Ala Cys Asn Ser Lys Lys Ser Glu 115 120 <210> 98 <211> 336 <212> DNA <213> Saccharomyces cerevisiae Page 146 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(336) <400> 98 atg act aaa agt ata tat att atc atc gga tat atg cta cat gat gag 48 Met Thr Lys Ser Ile Tyr Ile Ile Ile Gly Tyr Met Leu His Asp Glu 1 5 10 15 gag ttt ttc tat ttc ttt ttt att tca ttc tat aca ctt tgg atc gtg 96 Glu Phe Phe Tyr Phe Phe Phe Ile Ser Phe Tyr Thr Leu Trp Ile Val 20 25 30 ttt ttt ctt ttg cac ttg agt ttc ttt tca aca tta tca ttc ggt ata 144 Phe Phe Leu Leu His Leu Ser Phe Phe Ser Thr Leu Ser Phe Gly Ile 35 40 45 ttt cac gat ttt gac acc gat gtt tac ata aaa gtg ggt aat tat att 192 Phe His Asp Phe Asp Thr Asp Val Tyr Ile Lys Val Gly Asn Tyr Ile 50 55 60 ttg cat ttt ctc gaa ttg agt aaa aat agt aac ctt tta aag aat tct 240 Leu His Phe Leu Glu Leu Ser Lys Asn Ser Asn Leu Leu Lys Asn Ser 65 70 75 80 tca gaa atg tta aag cat ttc cga ttg gca tca ttg atg tat atg tac 288 Ser Glu Met Leu Lys His Phe Arg Leu Ala Ser Leu Met Tyr Met Tyr 85 90 95 gta tat act cag atg att tgc ccc tcg tta ctt ggc atc agg aat tag 336 Val Tyr Thr Gln Met Ile Cys Pro Ser Leu Leu Gly Ile Arg Asn 100 105 110 <210> 99 <211> 111 <212> PRT <213> Saccharomyces cerevisiae <400> 99 Met Thr Lys Ser Ile Tyr Ile Ile Ile Gly Tyr Met Leu His Asp Glu 1 5 10 15 Glu Phe Phe Tyr Phe Phe Phe Ile Ser Phe Tyr Thr Leu Trp Ile Val 20 25 30 Phe Phe Leu Leu His Leu Ser Phe Phe Ser Thr Leu Ser Phe Gly Ile 35 40 45 Phe His Asp Phe Asp Thr Asp Val Tyr Ile Lys Val Gly Asn Tyr Ile 50 55 60 Leu His Phe Leu Glu Leu Ser Lys Asn Ser Asn Leu Leu Lys Asn Ser 65 70 75 80 Ser Glu Met Leu Lys His Phe Arg Leu Ala Ser Leu Met Tyr Met Tyr 85 90 95 Val Tyr Thr Gln Met Ile Cys Pro Ser Leu Leu Gly Ile Arg Asn 100 105 110 Page 147 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 100 <211> 801 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(801) <400> 100 atg ttc tta aga agc gtt aac cgt gcc gtc act aga agc att ttg act 48 Met Phe Leu Arg Ser Val Asn Arg Ala Val Thr Arg Ser Ile Leu Thr 1 5 10 15 acg ccc aag cca gcc gta gta aaa tca tcg tgg aga gtt ttt act gtt 96 Thr Pro Lys Pro Ala Val Val Lys Ser Ser Trp Arg Val Phe Thr Val 20 25 30 gct aac tct aag aga tgt ttc aca ccc gct gca atc atg agg aac caa 144 Ala Asn Ser Lys Arg Cys Phe Thr Pro Ala Ala Ile Met Arg Asn Gln 35 40 45 gag acc caa aga gta ggt gat att ttg caa tct gaa ttg aaa att gag 192 Glu Thr Gln Arg Val Gly Asp Ile Leu Gln Ser Glu Leu Lys Ile Glu 50 55 60 aag gaa acg tta cca gag tca acg tcg tta gac tca ttt aat gac ttt 240 Lys Glu Thr Leu Pro Glu Ser Thr Ser Leu Asp Ser Phe Asn Asp Phe 65 70 75 80 ttg aac aaa tat aag ttc tca tta gta gag aca ccc ggt aag aat gaa 288 Leu Asn Lys Tyr Lys Phe Ser Leu Val Glu Thr Pro Gly Lys Asn Glu 85 90 95 gct gaa ata gtt aga aga acc gaa tca ggc gaa aca gtt cat gtt ttt 336 Ala Glu Ile Val Arg Arg Thr Glu Ser Gly Glu Thr Val His Val Phe 100 105 110 ttt gac gta gct cag att gct aat ctg cct tac aac aac gca atg gat 384 Phe Asp Val Ala Gln Ile Ala Asn Leu Pro Tyr Asn Asn Ala Met Asp 115 120 125 gaa aat acc gag caa aat gaa gac ggc att aat gag gat gat ttt gat 432 Glu Asn Thr Glu Gln Asn Glu Asp Gly Ile Asn Glu Asp Asp Phe Asp 130 135 140 gct tta tca gac aac ttt gcc aac gtt aat gtt gtt att tct aaa gaa 480 Ala Leu Ser Asp Asn Phe Ala Asn Val Asn Val Val Ile Ser Lys Glu 145 150 155 160 agc gca agc gaa cct gca gtc tca ttt gaa tta cta atg aat tta cag 528 Ser Ala Ser Glu Pro Ala Val Ser Phe Glu Leu Leu Met Asn Leu Gln 165 170 175 gaa ggt tca ttt tat gtt gat agt gct act cca tac ccc tca gtt gat 576 Glu Gly Ser Phe Tyr Val Asp Ser Ala Thr Pro Tyr Pro Ser Val Asp 180 185 190 gct gct ttg aat cag tct gct gag gcc gaa ata aca aga gaa ttg gta 624 Ala Ala Leu Asn Gln Ser Ala Glu Ala Glu Ile Thr Arg Glu Leu Val 195 200 205 tac cat ggc cca cct ttt tca aac ttg gac gaa gaa cta caa gaa tct 672 Tyr His Gly Pro Pro Phe Ser Asn Leu Asp Glu Glu Leu Gln Glu Ser 210 215 220 Page 148 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ctg gaa gct tat ttg gaa agt aga ggt gtc aat gaa gag cta gcc tct 720 Leu Glu Ala Tyr Leu Glu Ser Arg Gly Val Asn Glu Glu Leu Ala Ser 225 230 235 240 ttc att agt gca tat tcc gag ttc aaa gag aat aac gag tat att tct 768 Phe Ile Ser Ala Tyr Ser Glu Phe Lys Glu Asn Asn Glu Tyr Ile Ser 245 250 255 tgg ttg gaa aag atg aag aag ttt ttc cac taa 801 Trp Leu Glu Lys Met Lys Lys Phe Phe His 260 265 <210> 101 <211> 266 <212> PRT <213> Saccharomyces cerevisiae <400> 101 Met Phe Leu Arg Ser Val Asn Arg Ala Val Thr Arg Ser Ile Leu Thr 1 5 10 15 Thr Pro Lys Pro Ala Val Val Lys Ser Ser Trp Arg Val Phe Thr Val 20 25 30 Ala Asn Ser Lys Arg Cys Phe Thr Pro Ala Ala Ile Met Arg Asn Gln 35 40 45 Glu Thr Gln Arg Val Gly Asp Ile Leu Gln Ser Glu Leu Lys Ile Glu 50 55 60 Lys Glu Thr Leu Pro Glu Ser Thr Ser Leu Asp Ser Phe Asn Asp Phe 65 70 75 80 Leu Asn Lys Tyr Lys Phe Ser Leu Val Glu Thr Pro Gly Lys Asn Glu 85 90 95 Ala Glu Ile Val Arg Arg Thr Glu Ser Gly Glu Thr Val His Val Phe 100 105 110 Phe Asp Val Ala Gln Ile Ala Asn Leu Pro Tyr Asn Asn Ala Met Asp 115 120 125 Glu Asn Thr Glu Gln Asn Glu Asp Gly Ile Asn Glu Asp Asp Phe Asp 130 135 140 Ala Leu Ser Asp Asn Phe Ala Asn Val Asn Val Val Ile Ser Lys Glu 145 150 155 160 Ser Ala Ser Glu Pro Ala Val Ser Phe Glu Leu Leu Met Asn Leu Gln 165 170 175 Glu Gly Ser Phe Tyr Val Asp Ser Ala Thr Pro Tyr Pro Ser Val Asp 180 185 190 Page 149 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Ala Leu Asn Gln Ser Ala Glu Ala Glu Ile Thr Arg Glu Leu Val 195 200 205 Tyr His Gly Pro Pro Phe Ser Asn Leu Asp Glu Glu Leu Gln Glu Ser 210 215 220 Leu Glu Ala Tyr Leu Glu Ser Arg Gly Val Asn Glu Glu Leu Ala Ser 225 230 235 240 Phe Ile Ser Ala Tyr Ser Glu Phe Lys Glu Asn Asn Glu Tyr Ile Ser 245 250 255 Trp Leu Glu Lys Met Lys Lys Phe Phe His 260 265 <210> 102 <211> 966 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(966) <400> 102 atg act cgt ccc cca ttg gtt cgt gga atc ttt tcg tta ggt ctt tct 48 Met Thr Arg Pro Pro Leu Val Arg Gly Ile Phe Ser Leu Gly Leu Ser 1 5 10 15 gta gcc gtt ttg aaa ggt gtt gaa aaa aca gtt cgt aag cat ttg gaa 96 Val Ala Val Leu Lys Gly Val Glu Lys Thr Val Arg Lys His Leu Glu 20 25 30 aga cag gga tgg ata gag ccc cag aaa gtg gac tat gag tta att ttc 144 Arg Gln Gly Trp Ile Glu Pro Gln Lys Val Asp Tyr Glu Leu Ile Phe 35 40 45 act ata gat agg ttg aaa aac ttg gta gat aat aag cgt gag gct tta 192 Thr Ile Asp Arg Leu Lys Asn Leu Val Asp Asn Lys Arg Glu Ala Leu 50 55 60 act gcg gaa caa ccc gac gct ggt gaa ctg agc tgg cgt aaa gta ttt 240 Thr Ala Glu Gln Pro Asp Ala Gly Glu Leu Ser Trp Arg Lys Val Phe 65 70 75 80 aat ttc att tcc aga caa tcc agc gaa ttg gac aca cga ata tac gtt 288 Asn Phe Ile Ser Arg Gln Ser Ser Glu Leu Asp Thr Arg Ile Tyr Val 85 90 95 ctt ata cta ctc cta tcc ttt cta cta cct atc gcg tgg act gta ctg 336 Leu Ile Leu Leu Leu Ser Phe Leu Leu Pro Ile Ala Trp Thr Val Leu 100 105 110 gac ggt gat cgc gag acc acg cta gaa gat aag gat aac gat tgt aat 384 Asp Gly Asp Arg Glu Thr Thr Leu Glu Asp Lys Asp Asn Asp Cys Asn 115 120 125 gta gat ctt att gaa aac gaa agg agg ctg aag cat tac aac gat ggt 432 Val Asp Leu Ile Glu Asn Glu Arg Arg Leu Lys His Tyr Asn Asp Gly 130 135 140 Page 150 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa aga gca gta ttg caa ttt ggt aaa aat aga tcc gaa cct att ata 480 Glu Arg Ala Val Leu Gln Phe Gly Lys Asn Arg Ser Glu Pro Ile Ile 145 150 155 160 tta agc tat aag gac atg aac gtt ttg gaa ggg gaa cat gag ttt acc 528 Leu Ser Tyr Lys Asp Met Asn Val Leu Glu Gly Glu His Glu Phe Thr 165 170 175 tcc aaa gag gaa cac agt aac agc cat ttg aca agc aag agc gaa aat 576 Ser Lys Glu Glu His Ser Asn Ser His Leu Thr Ser Lys Ser Glu Asn 180 185 190 gca cta aac caa gta ggg agt gaa gat ttg tta ggt tgt cac ctg gaa 624 Ala Leu Asn Gln Val Gly Ser Glu Asp Leu Leu Gly Cys His Leu Glu 195 200 205 aag caa ttg gaa gaa gac aaa aat gaa ccg aat gga gaa gca gac ggt 672 Lys Gln Leu Glu Glu Asp Lys Asn Glu Pro Asn Gly Glu Ala Asp Gly 210 215 220 gag gat gat aat aac cgg gaa aag gat tgc agc tcc agt tca gaa gtt 720 Glu Asp Asp Asn Asn Arg Glu Lys Asp Cys Ser Ser Ser Ser Glu Val 225 230 235 240 gag tcg cag agt aaa tgc cga aag gaa agt act gca gag cct gac tct 768 Glu Ser Gln Ser Lys Cys Arg Lys Glu Ser Thr Ala Glu Pro Asp Ser 245 250 255 ctc tca cgg gat acc aga aca acc tct tcc ctt aaa tca agt aca tca 816 Leu Ser Arg Asp Thr Arg Thr Thr Ser Ser Leu Lys Ser Ser Thr Ser 260 265 270 ttc ccc ata tca ttc aag ggc tcg ata gac ctt aag tcg tta aac cag 864 Phe Pro Ile Ser Phe Lys Gly Ser Ile Asp Leu Lys Ser Leu Asn Gln 275 280 285 cct tca tca ttg ttg cat ata caa gta tct ccc aca aaa tct agt aat 912 Pro Ser Ser Leu Leu His Ile Gln Val Ser Pro Thr Lys Ser Ser Asn 290 295 300 cta gat gca caa gtg aac act gaa caa gca tac tct caa cca ttt aga 960 Leu Asp Ala Gln Val Asn Thr Glu Gln Ala Tyr Ser Gln Pro Phe Arg 305 310 315 320 tac taa 966 Tyr <210> 103 <211> 321 <212> PRT <213> Saccharomyces cerevisiae <400> 103 Met Thr Arg Pro Pro Leu Val Arg Gly Ile Phe Ser Leu Gly Leu Ser 1 5 10 15 Val Ala Val Leu Lys Gly Val Glu Lys Thr Val Arg Lys His Leu Glu 20 25 30 Arg Gln Gly Trp Ile Glu Pro Gln Lys Val Asp Tyr Glu Leu Ile Phe 35 40 45 Page 151 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Ile Asp Arg Leu Lys Asn Leu Val Asp Asn Lys Arg Glu Ala Leu 50 55 60 Thr Ala Glu Gln Pro Asp Ala Gly Glu Leu Ser Trp Arg Lys Val Phe 65 70 75 80 Asn Phe Ile Ser Arg Gln Ser Ser Glu Leu Asp Thr Arg Ile Tyr Val 85 90 95 Leu Ile Leu Leu Leu Ser Phe Leu Leu Pro Ile Ala Trp Thr Val Leu 100 105 110 Asp Gly Asp Arg Glu Thr Thr Leu Glu Asp Lys Asp Asn Asp Cys Asn 115 120 125 Val Asp Leu Ile Glu Asn Glu Arg Arg Leu Lys His Tyr Asn Asp Gly 130 135 140 Glu Arg Ala Val Leu Gln Phe Gly Lys Asn Arg Ser Glu Pro Ile Ile 145 150 155 160 Leu Ser Tyr Lys Asp Met Asn Val Leu Glu Gly Glu His Glu Phe Thr 165 170 175 Ser Lys Glu Glu His Ser Asn Ser His Leu Thr Ser Lys Ser Glu Asn 180 185 190 Ala Leu Asn Gln Val Gly Ser Glu Asp Leu Leu Gly Cys His Leu Glu 195 200 205 Lys Gln Leu Glu Glu Asp Lys Asn Glu Pro Asn Gly Glu Ala Asp Gly 210 215 220 Glu Asp Asp Asn Asn Arg Glu Lys Asp Cys Ser Ser Ser Ser Glu Val 225 230 235 240 Glu Ser Gln Ser Lys Cys Arg Lys Glu Ser Thr Ala Glu Pro Asp Ser 245 250 255 Leu Ser Arg Asp Thr Arg Thr Thr Ser Ser Leu Lys Ser Ser Thr Ser 260 265 270 Phe Pro Ile Ser Phe Lys Gly Ser Ile Asp Leu Lys Ser Leu Asn Gln 275 280 285 Pro Ser Ser Leu Leu His Ile Gln Val Ser Pro Thr Lys Ser Ser Asn 290 295 300 Leu Asp Ala Gln Val Asn Thr Glu Gln Ala Tyr Ser Gln Pro Phe Arg 305 310 315 320 Page 152 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Tyr <210> 104 <211> 504 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(504) <400> 104 atg aat cta aga ttt gaa ttg cag aaa cta ttg aac gtt tgc ttt ttg 48 Met Asn Leu Arg Phe Glu Leu Gln Lys Leu Leu Asn Val Cys Phe Leu 1 5 10 15 ttt gca tct gct tac atg ttc tgg caa ggc tta gcc att gct act aat 96 Phe Ala Ser Ala Tyr Met Phe Trp Gln Gly Leu Ala Ile Ala Thr Asn 20 25 30 agc gct tct ccg atc gtg gtg gtg ctt tca ggc tcc atg gaa cca gct 144 Ser Ala Ser Pro Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala 35 40 45 ttc caa agg ggt gat atc ctt ttc cta tgg aat aga aat act ttc aac 192 Phe Gln Arg Gly Asp Ile Leu Phe Leu Trp Asn Arg Asn Thr Phe Asn 50 55 60 caa gta ggt gat gtc gtg gtg tat gag gtc gaa ggg aaa caa atc ccc 240 Gln Val Gly Asp Val Val Val Tyr Glu Val Glu Gly Lys Gln Ile Pro 65 70 75 80 att gtg cat aga gtt ttg agg caa cat aac aat cac gcg gac aag caa 288 Ile Val His Arg Val Leu Arg Gln His Asn Asn His Ala Asp Lys Gln 85 90 95 ttc ctc ctg acc aaa ggt gac aat aac gcc ggc aat gat atc tca cta 336 Phe Leu Leu Thr Lys Gly Asp Asn Asn Ala Gly Asn Asp Ile Ser Leu 100 105 110 tat gct aat aag aaa att tac ttg aac aag tca aag gag att gta ggg 384 Tyr Ala Asn Lys Lys Ile Tyr Leu Asn Lys Ser Lys Glu Ile Val Gly 115 120 125 acc gtc aag ggc tac ttt cca caa cta ggg tac att acg att tgg att 432 Thr Val Lys Gly Tyr Phe Pro Gln Leu Gly Tyr Ile Thr Ile Trp Ile 130 135 140 agc gag aac aaa tat gcc aag ttt gca ttg tta ggt atg ttg ggg ttg 480 Ser Glu Asn Lys Tyr Ala Lys Phe Ala Leu Leu Gly Met Leu Gly Leu 145 150 155 160 agt gct ctg ctg ggg ggc gag tag 504 Ser Ala Leu Leu Gly Gly Glu 165 <210> 105 <211> 167 <212> PRT <213> Saccharomyces cerevisiae <400> 105 Page 153 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Asn Leu Arg Phe Glu Leu Gln Lys Leu Leu Asn Val Cys Phe Leu 1 5 10 15 Phe Ala Ser Ala Tyr Met Phe Trp Gln Gly Leu Ala Ile Ala Thr Asn 20 25 30 Ser Ala Ser Pro Ile Val Val Val Leu Ser Gly Ser Met Glu Pro Ala 35 40 45 Phe Gln Arg Gly Asp Ile Leu Phe Leu Trp Asn Arg Asn Thr Phe Asn 50 55 60 Gln Val Gly Asp Val Val Val Tyr Glu Val Glu Gly Lys Gln Ile Pro 65 70 75 80 Ile Val His Arg Val Leu Arg Gln His Asn Asn His Ala Asp Lys Gln 85 90 95 Phe Leu Leu Thr Lys Gly Asp Asn Asn Ala Gly Asn Asp Ile Ser Leu 100 105 110 Tyr Ala Asn Lys Lys Ile Tyr Leu Asn Lys Ser Lys Glu Ile Val Gly 115 120 125 Thr Val Lys Gly Tyr Phe Pro Gln Leu Gly Tyr Ile Thr Ile Trp Ile 130 135 140 Ser Glu Asn Lys Tyr Ala Lys Phe Ala Leu Leu Gly Met Leu Gly Leu 145 150 155 160 Ser Ala Leu Leu Gly Gly Glu 165 <210> 106 <211> 2490 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2490) <400> 106 atg gcc aag agg aaa tat ggc agg tct tat tcc ctc gat gat aca gat 48 Met Ala Lys Arg Lys Tyr Gly Arg Ser Tyr Ser Leu Asp Asp Thr Asp 1 5 10 15 tcc tgc agc aat aaa gtc ctg ata gta cca acc ggt caa agc tcc tct 96 Ser Cys Ser Asn Lys Val Leu Ile Val Pro Thr Gly Gln Ser Ser Ser 20 25 30 aac gca atc act gat ttc tct gtc aga aag gcg cat gct tgc gat aga 144 Asn Ala Ile Thr Asp Phe Ser Val Arg Lys Ala His Ala Cys Asp Arg 35 40 45 Page 154 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tgc aga ctg aaa aaa atc aag tgt gac ggt tta aaa ccg aac tgt tca 192 Cys Arg Leu Lys Lys Ile Lys Cys Asp Gly Leu Lys Pro Asn Cys Ser 50 55 60 aac tgt gcg aaa att gac ttc cct tgc aaa acc tcg gat aaa ctg tcg 240 Asn Cys Ala Lys Ile Asp Phe Pro Cys Lys Thr Ser Asp Lys Leu Ser 65 70 75 80 agg aga ggt ctt cca aag ggg tat aca gaa cta cta gaa aaa gag gtc 288 Arg Arg Gly Leu Pro Lys Gly Tyr Thr Glu Leu Leu Glu Lys Glu Val 85 90 95 gtc cgt ttg aca aat atg aat gcg agt tcc agc gcc aat gca aat tct 336 Val Arg Leu Thr Asn Met Asn Ala Ser Ser Ser Ala Asn Ala Asn Ser 100 105 110 aat ttg ccg ttc att aat gat aca ttt tat tgt ttt gat aat tac aac 384 Asn Leu Pro Phe Ile Asn Asp Thr Phe Tyr Cys Phe Asp Asn Tyr Asn 115 120 125 act cag tct gaa aat caa agg ttt ttg gga cat ttg aca tgg aat att 432 Thr Gln Ser Glu Asn Gln Arg Phe Leu Gly His Leu Thr Trp Asn Ile 130 135 140 cta act aat act ttt cct act caa aaa gca gta gtt ttt aca gac gat 480 Leu Thr Asn Thr Phe Pro Thr Gln Lys Ala Val Val Phe Thr Asp Asp 145 150 155 160 cga aat aat att gat cta caa ctg caa ctg tta aca aat ttt ttg aac 528 Arg Asn Asn Ile Asp Leu Gln Leu Gln Leu Leu Thr Asn Phe Leu Asn 165 170 175 ctg aat ggt gac ttt aat cat ctc cca aat ttt ctt tta ctt aaa tat 576 Leu Asn Gly Asp Phe Asn His Leu Pro Asn Phe Leu Leu Leu Lys Tyr 180 185 190 gat tat aac ctt cag ttt ttg aaa aat ttg ttg tct gtc att att aaa 624 Asp Tyr Asn Leu Gln Phe Leu Lys Asn Leu Leu Ser Val Ile Ile Lys 195 200 205 gat ttt ttt aaa agg caa aat tct ttg cta ctt cta tta tac cct aca 672 Asp Phe Phe Lys Arg Gln Asn Ser Leu Leu Leu Leu Leu Tyr Pro Thr 210 215 220 aat tta tgg aaa aat ttg cta tta gac aag att aat tca acc gca atg 720 Asn Leu Trp Lys Asn Leu Leu Leu Asp Lys Ile Asn Ser Thr Ala Met 225 230 235 240 aca ggt gaa ccc ata act cta ctg gcg tta ctt tat att att caa ttt 768 Thr Gly Glu Pro Ile Thr Leu Leu Ala Leu Leu Tyr Ile Ile Gln Phe 245 250 255 act tgg tct tgt ttt gat gat ttc aag ctt ttt aaa gtc acg aag ctt 816 Thr Trp Ser Cys Phe Asp Asp Phe Lys Leu Phe Lys Val Thr Lys Leu 260 265 270 att gtt tct ctg aca aca aac agc aaa tta gac ttg aaa gtt ttg caa 864 Ile Val Ser Leu Thr Thr Asn Ser Lys Leu Asp Leu Lys Val Leu Gln 275 280 285 ttg gtt aac tta tcc atc ttt tat ttt atg ggc gcc tct gtt gac tct 912 Leu Val Asn Leu Ser Ile Phe Tyr Phe Met Gly Ala Ser Val Asp Ser 290 295 300 tgt aaa agt aaa agc tcg tta aca gaa cat tca aat gta aat tca gta 960 Cys Lys Ser Lys Ser Ser Leu Thr Glu His Ser Asn Val Asn Ser Val 305 310 315 320 Page 155 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ata tgg acc aat gat ttg cta aac cta aac ttt aca aat att ttg aat 1008 Ile Trp Thr Asn Asp Leu Leu Asn Leu Asn Phe Thr Asn Ile Leu Asn 325 330 335 atg gga ttg tac ata aat ccc aaa aat tta att cct ata tca ggc aac 1056 Met Gly Leu Tyr Ile Asn Pro Lys Asn Leu Ile Pro Ile Ser Gly Asn 340 345 350 aat aat aat aat aaa tct aat gaa gag gat gat aga ata gtg aca ttt 1104 Asn Asn Asn Asn Lys Ser Asn Glu Glu Asp Asp Arg Ile Val Thr Phe 355 360 365 tgg tgc ttt caa ttc tta agc tca tgg tgg tcc tta att caa ggt tta 1152 Trp Cys Phe Gln Phe Leu Ser Ser Trp Trp Ser Leu Ile Gln Gly Leu 370 375 380 cca aag tcc aac ttt tta act gaa gaa ttt caa ccg aaa tca atc tcg 1200 Pro Lys Ser Asn Phe Leu Thr Glu Glu Phe Gln Pro Lys Ser Ile Ser 385 390 395 400 gtt cta gaa atc ccc agg ctg aag ccc ttt gaa att ttg tta aac ttc 1248 Val Leu Glu Ile Pro Arg Leu Lys Pro Phe Glu Ile Leu Leu Asn Phe 405 410 415 atc ata tat tct ttg gat gga tgt aat ttg ttg aat atc tca tct tta 1296 Ile Ile Tyr Ser Leu Asp Gly Cys Asn Leu Leu Asn Ile Ser Ser Leu 420 425 430 aat gtt tcg gac cca aat ttc caa ttt ttc cag aat gaa ctg gaa agc 1344 Asn Val Ser Asp Pro Asn Phe Gln Phe Phe Gln Asn Glu Leu Glu Ser 435 440 445 ttt aaa aaa aat tta tta ctg tgg aac ctt tat cac aat ttg agt gat 1392 Phe Lys Lys Asn Leu Leu Leu Trp Asn Leu Tyr His Asn Leu Ser Asp 450 455 460 cac gat aac ttc cga ttc tta aca tcc agt tca aat aaa aaa cta aca 1440 His Asp Asn Phe Arg Phe Leu Thr Ser Ser Ser Asn Lys Lys Leu Thr 465 470 475 480 aca aat tta cta ctt aag aat ttg acg ggt cta aat cac aaa ctc aat 1488 Thr Asn Leu Leu Leu Lys Asn Leu Thr Gly Leu Asn His Lys Leu Asn 485 490 495 caa cct gat ttt gtg gag att caa tta act tta ttt tac ttg agt tta 1536 Gln Pro Asp Phe Val Glu Ile Gln Leu Thr Leu Phe Tyr Leu Ser Leu 500 505 510 aaa tta atg act tta aag gaa ggg gac caa gat ttg aag aaa gag gat 1584 Lys Leu Met Thr Leu Lys Glu Gly Asp Gln Asp Leu Lys Lys Glu Asp 515 520 525 atc tcg tta gag ata ttg tcc cta tat ttt tta att ctt aca gat gac 1632 Ile Ser Leu Glu Ile Leu Ser Leu Tyr Phe Leu Ile Leu Thr Asp Asp 530 535 540 tct aat aat gat gat aat caa cag tta caa cca cag caa cta aat ctc 1680 Ser Asn Asn Asp Asp Asn Gln Gln Leu Gln Pro Gln Gln Leu Asn Leu 545 550 555 560 tac cat ttt acg ccc ttc aat agt att gac att att gac tta tgt tta 1728 Tyr His Phe Thr Pro Phe Asn Ser Ile Asp Ile Ile Asp Leu Cys Leu 565 570 575 aac aat tta aac aat tgg tca tta tca ctt aaa tac gaa agt ggt caa 1776 Asn Asn Leu Asn Asn Trp Ser Leu Ser Leu Lys Tyr Glu Ser Gly Gln 580 585 590 Page 156 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aac cag ccc cac tca agt aaa ata aag ttt gaa aaa ttt caa aac ttt 1824 Asn Gln Pro His Ser Ser Lys Ile Lys Phe Glu Lys Phe Gln Asn Phe 595 600 605 tta aat cac tgg tgt cca ata tgg tac tat gat gaa ttt tcc aca aac 1872 Leu Asn His Trp Cys Pro Ile Trp Tyr Tyr Asp Glu Phe Ser Thr Asn 610 615 620 cct ttt tta caa atc ctc aaa atc aat ttc aaa tta ctt cct ttt gag 1920 Pro Phe Leu Gln Ile Leu Lys Ile Asn Phe Lys Leu Leu Pro Phe Glu 625 630 635 640 aca atc cat tac tca caa gaa gag caa cga ttg tta ata agt ttg aat 1968 Thr Ile His Tyr Ser Gln Glu Glu Gln Arg Leu Leu Ile Ser Leu Asn 645 650 655 aaa ttg aga tat ttg gat gcc gta tcg agc ttt aat tca agt tca gtc 2016 Lys Leu Arg Tyr Leu Asp Ala Val Ser Ser Phe Asn Ser Ser Ser Val 660 665 670 aag tcg aat ttc gcg tct aag gtc aat acc cag cta aac ctt ttg caa 2064 Lys Ser Asn Phe Ala Ser Lys Val Asn Thr Gln Leu Asn Leu Leu Gln 675 680 685 cac tcg agt tct aac tcc aat ttc cta gat gcg tca cca tac gat ttt 2112 His Ser Ser Ser Asn Ser Asn Phe Leu Asp Ala Ser Pro Tyr Asp Phe 690 695 700 aat aaa att ttt atg aac aac ttt gaa aac tat gac tac gaa aca gat 2160 Asn Lys Ile Phe Met Asn Asn Phe Glu Asn Tyr Asp Tyr Glu Thr Asp 705 710 715 720 gaa gga tat gcg gaa gat gat gat gaa gag gat agt gac agt gac aat 2208 Glu Gly Tyr Ala Glu Asp Asp Asp Glu Glu Asp Ser Asp Ser Asp Asn 725 730 735 agc tta cca cta gaa att cct ttt aaa aaa agt aaa aat aaa tgc aag 2256 Ser Leu Pro Leu Glu Ile Pro Phe Lys Lys Ser Lys Asn Lys Cys Lys 740 745 750 aat agg aat aaa gag ctt tca caa agg tta tcc cta ttt gaa aac aga 2304 Asn Arg Asn Lys Glu Leu Ser Gln Arg Leu Ser Leu Phe Glu Asn Arg 755 760 765 gat agc aat tcg gta gat ttc aac aca gat aca aat tta aat tta aac 2352 Asp Ser Asn Ser Val Asp Phe Asn Thr Asp Thr Asn Leu Asn Leu Asn 770 775 780 cct gat tcg cca tca gtt acg tct tct aag aaa aaa tat tta gat cat 2400 Pro Asp Ser Pro Ser Val Thr Ser Ser Lys Lys Lys Tyr Leu Asp His 785 790 795 800 att att tta gat aac cga gac atc gtt agc aac cat gac tcc agt aaa 2448 Ile Ile Leu Asp Asn Arg Asp Ile Val Ser Asn His Asp Ser Ser Lys 805 810 815 caa aaa ttc aag atc cag aat att ttg aac tcg acc ttc taa 2490 Gln Lys Phe Lys Ile Gln Asn Ile Leu Asn Ser Thr Phe 820 825 <210> 107 <211> 829 <212> PRT <213> Saccharomyces cerevisiae <400> 107 Page 157 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Ala Lys Arg Lys Tyr Gly Arg Ser Tyr Ser Leu Asp Asp Thr Asp 1 5 10 15 Ser Cys Ser Asn Lys Val Leu Ile Val Pro Thr Gly Gln Ser Ser Ser 20 25 30 Asn Ala Ile Thr Asp Phe Ser Val Arg Lys Ala His Ala Cys Asp Arg 35 40 45 Cys Arg Leu Lys Lys Ile Lys Cys Asp Gly Leu Lys Pro Asn Cys Ser 50 55 60 Asn Cys Ala Lys Ile Asp Phe Pro Cys Lys Thr Ser Asp Lys Leu Ser 65 70 75 80 Arg Arg Gly Leu Pro Lys Gly Tyr Thr Glu Leu Leu Glu Lys Glu Val 85 90 95 Val Arg Leu Thr Asn Met Asn Ala Ser Ser Ser Ala Asn Ala Asn Ser 100 105 110 Asn Leu Pro Phe Ile Asn Asp Thr Phe Tyr Cys Phe Asp Asn Tyr Asn 115 120 125 Thr Gln Ser Glu Asn Gln Arg Phe Leu Gly His Leu Thr Trp Asn Ile 130 135 140 Leu Thr Asn Thr Phe Pro Thr Gln Lys Ala Val Val Phe Thr Asp Asp 145 150 155 160 Arg Asn Asn Ile Asp Leu Gln Leu Gln Leu Leu Thr Asn Phe Leu Asn 165 170 175 Leu Asn Gly Asp Phe Asn His Leu Pro Asn Phe Leu Leu Leu Lys Tyr 180 185 190 Asp Tyr Asn Leu Gln Phe Leu Lys Asn Leu Leu Ser Val Ile Ile Lys 195 200 205 Asp Phe Phe Lys Arg Gln Asn Ser Leu Leu Leu Leu Leu Tyr Pro Thr 210 215 220 Asn Leu Trp Lys Asn Leu Leu Leu Asp Lys Ile Asn Ser Thr Ala Met 225 230 235 240 Thr Gly Glu Pro Ile Thr Leu Leu Ala Leu Leu Tyr Ile Ile Gln Phe 245 250 255 Thr Trp Ser Cys Phe Asp Asp Phe Lys Leu Phe Lys Val Thr Lys Leu 260 265 270 Page 158 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Val Ser Leu Thr Thr Asn Ser Lys Leu Asp Leu Lys Val Leu Gln 275 280 285 Leu Val Asn Leu Ser Ile Phe Tyr Phe Met Gly Ala Ser Val Asp Ser 290 295 300 Cys Lys Ser Lys Ser Ser Leu Thr Glu His Ser Asn Val Asn Ser Val 305 310 315 320 Ile Trp Thr Asn Asp Leu Leu Asn Leu Asn Phe Thr Asn Ile Leu Asn 325 330 335 Met Gly Leu Tyr Ile Asn Pro Lys Asn Leu Ile Pro Ile Ser Gly Asn 340 345 350 Asn Asn Asn Asn Lys Ser Asn Glu Glu Asp Asp Arg Ile Val Thr Phe 355 360 365 Trp Cys Phe Gln Phe Leu Ser Ser Trp Trp Ser Leu Ile Gln Gly Leu 370 375 380 Pro Lys Ser Asn Phe Leu Thr Glu Glu Phe Gln Pro Lys Ser Ile Ser 385 390 395 400 Val Leu Glu Ile Pro Arg Leu Lys Pro Phe Glu Ile Leu Leu Asn Phe 405 410 415 Ile Ile Tyr Ser Leu Asp Gly Cys Asn Leu Leu Asn Ile Ser Ser Leu 420 425 430 Asn Val Ser Asp Pro Asn Phe Gln Phe Phe Gln Asn Glu Leu Glu Ser 435 440 445 Phe Lys Lys Asn Leu Leu Leu Trp Asn Leu Tyr His Asn Leu Ser Asp 450 455 460 His Asp Asn Phe Arg Phe Leu Thr Ser Ser Ser Asn Lys Lys Leu Thr 465 470 475 480 Thr Asn Leu Leu Leu Lys Asn Leu Thr Gly Leu Asn His Lys Leu Asn 485 490 495 Gln Pro Asp Phe Val Glu Ile Gln Leu Thr Leu Phe Tyr Leu Ser Leu 500 505 510 Lys Leu Met Thr Leu Lys Glu Gly Asp Gln Asp Leu Lys Lys Glu Asp 515 520 525 Ile Ser Leu Glu Ile Leu Ser Leu Tyr Phe Leu Ile Leu Thr Asp Asp 530 535 540 Page 159 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Asn Asn Asp Asp Asn Gln Gln Leu Gln Pro Gln Gln Leu Asn Leu 545 550 555 560 Tyr His Phe Thr Pro Phe Asn Ser Ile Asp Ile Ile Asp Leu Cys Leu 565 570 575 Asn Asn Leu Asn Asn Trp Ser Leu Ser Leu Lys Tyr Glu Ser Gly Gln 580 585 590 Asn Gln Pro His Ser Ser Lys Ile Lys Phe Glu Lys Phe Gln Asn Phe 595 600 605 Leu Asn His Trp Cys Pro Ile Trp Tyr Tyr Asp Glu Phe Ser Thr Asn 610 615 620 Pro Phe Leu Gln Ile Leu Lys Ile Asn Phe Lys Leu Leu Pro Phe Glu 625 630 635 640 Thr Ile His Tyr Ser Gln Glu Glu Gln Arg Leu Leu Ile Ser Leu Asn 645 650 655 Lys Leu Arg Tyr Leu Asp Ala Val Ser Ser Phe Asn Ser Ser Ser Val 660 665 670 Lys Ser Asn Phe Ala Ser Lys Val Asn Thr Gln Leu Asn Leu Leu Gln 675 680 685 His Ser Ser Ser Asn Ser Asn Phe Leu Asp Ala Ser Pro Tyr Asp Phe 690 695 700 Asn Lys Ile Phe Met Asn Asn Phe Glu Asn Tyr Asp Tyr Glu Thr Asp 705 710 715 720 Glu Gly Tyr Ala Glu Asp Asp Asp Glu Glu Asp Ser Asp Ser Asp Asn 725 730 735 Ser Leu Pro Leu Glu Ile Pro Phe Lys Lys Ser Lys Asn Lys Cys Lys 740 745 750 Asn Arg Asn Lys Glu Leu Ser Gln Arg Leu Ser Leu Phe Glu Asn Arg 755 760 765 Asp Ser Asn Ser Val Asp Phe Asn Thr Asp Thr Asn Leu Asn Leu Asn 770 775 780 Pro Asp Ser Pro Ser Val Thr Ser Ser Lys Lys Lys Tyr Leu Asp His 785 790 795 800 Ile Ile Leu Asp Asn Arg Asp Ile Val Ser Asn His Asp Ser Ser Lys 805 810 815 Page 160 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Lys Phe Lys Ile Gln Asn Ile Leu Asn Ser Thr Phe 820 825 <210> 108 <211> 1731 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1731) <400> 108 atg atc gcc tta cca gta gag aag gcc cct aga aag tcc cta tgg caa 48 Met Ile Ala Leu Pro Val Glu Lys Ala Pro Arg Lys Ser Leu Trp Gln 1 5 10 15 agg cac aga gcc ttt att agt gga ata gtt gcc ctt att atc atc ggc 96 Arg His Arg Ala Phe Ile Ser Gly Ile Val Ala Leu Ile Ile Ile Gly 20 25 30 acc ttc ttc ctc act tcg ggt ctc cac cca gca cca cct cat gag gca 144 Thr Phe Phe Leu Thr Ser Gly Leu His Pro Ala Pro Pro His Glu Ala 35 40 45 aag cgt cca cac cat gga aaa ggt ccc atg cac tca ccc aaa tgt gag 192 Lys Arg Pro His His Gly Lys Gly Pro Met His Ser Pro Lys Cys Glu 50 55 60 aag att gaa cca tta agt cca tca ttc aaa cat tcc gtc gac aca att 240 Lys Ile Glu Pro Leu Ser Pro Ser Phe Lys His Ser Val Asp Thr Ile 65 70 75 80 ctt cat gac cct gcc ttt aga aac agc tcc att gag aaa ctg tcc aat 288 Leu His Asp Pro Ala Phe Arg Asn Ser Ser Ile Glu Lys Leu Ser Asn 85 90 95 gct gtt aga atc ccc act gta gtc caa gac aaa aac ccc aac ccc gca 336 Ala Val Arg Ile Pro Thr Val Val Gln Asp Lys Asn Pro Asn Pro Ala 100 105 110 gat gat ccg gat ttc tat aag cat ttt tat gaa cta cac gac tat ttt 384 Asp Asp Pro Asp Phe Tyr Lys His Phe Tyr Glu Leu His Asp Tyr Phe 115 120 125 gag aag act ttc cct aat att cac aag cat ttg aaa ttg gag aaa gtc 432 Glu Lys Thr Phe Pro Asn Ile His Lys His Leu Lys Leu Glu Lys Val 130 135 140 aat gag ctg ggt ctt cta tac aca tgg gaa ggt tct gat cct gat cta 480 Asn Glu Leu Gly Leu Leu Tyr Thr Trp Glu Gly Ser Asp Pro Asp Leu 145 150 155 160 aaa cca tta ttg tta atg gcc cat caa gat gtt gta cct gta aac aac 528 Lys Pro Leu Leu Leu Met Ala His Gln Asp Val Val Pro Val Asn Asn 165 170 175 gaa act tta tca tcc tgg aag ttc cct cca ttt tct ggt cac tat gat 576 Glu Thr Leu Ser Ser Trp Lys Phe Pro Pro Phe Ser Gly His Tyr Asp 180 185 190 cca gaa aca gat ttt gtt tgg ggg cgt ggt tct aac gat tgt aag aac 624 Pro Glu Thr Asp Phe Val Trp Gly Arg Gly Ser Asn Asp Cys Lys Asn 195 200 205 Page 161 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttg tta att gcc gag ttt gaa gct atc gaa caa ctg ttg ata gat gga 672 Leu Leu Ile Ala Glu Phe Glu Ala Ile Glu Gln Leu Leu Ile Asp Gly 210 215 220 ttc aag ccc aac aga act att gtt atg tcg ctt ggt ttt gat gaa gaa 720 Phe Lys Pro Asn Arg Thr Ile Val Met Ser Leu Gly Phe Asp Glu Glu 225 230 235 240 gca agc ggc acc ctc ggt gct gcc agc tta gcc tca ttt ctt cac gaa 768 Ala Ser Gly Thr Leu Gly Ala Ala Ser Leu Ala Ser Phe Leu His Glu 245 250 255 aga tat ggt gat gat ggt att tac agt atc att gac gag ggt gaa ggt 816 Arg Tyr Gly Asp Asp Gly Ile Tyr Ser Ile Ile Asp Glu Gly Glu Gly 260 265 270 atc atg gaa gtc gac aag gat gtc ttt gtt gcc act cca atc aac gct 864 Ile Met Glu Val Asp Lys Asp Val Phe Val Ala Thr Pro Ile Asn Ala 275 280 285 gaa aaa ggc tat gtc gac ttc gaa gtc agt att cta ggc cat ggt ggt 912 Glu Lys Gly Tyr Val Asp Phe Glu Val Ser Ile Leu Gly His Gly Gly 290 295 300 cat tcc tct gtc cca cct gat cat acc aca atc ggt atc gct tca gaa 960 His Ser Ser Val Pro Pro Asp His Thr Thr Ile Gly Ile Ala Ser Glu 305 310 315 320 ctg att act gaa ttt gaa gcc aac cca ttt gac tac gaa ttt gag ttt 1008 Leu Ile Thr Glu Phe Glu Ala Asn Pro Phe Asp Tyr Glu Phe Glu Phe 325 330 335 gac aat cca atc tat gga ttg ttg aca tgt gct gct gaa cat tct aaa 1056 Asp Asn Pro Ile Tyr Gly Leu Leu Thr Cys Ala Ala Glu His Ser Lys 340 345 350 tct tta agt aag gat gtg aag aag aca att ttg ggc gca cca ttc tgt 1104 Ser Leu Ser Lys Asp Val Lys Lys Thr Ile Leu Gly Ala Pro Phe Cys 355 360 365 cct aga agg aag gac aag ctt gtt gag tac att tcc aac caa tca cat 1152 Pro Arg Arg Lys Asp Lys Leu Val Glu Tyr Ile Ser Asn Gln Ser His 370 375 380 ttg cgc agc tta ata aga aca aca caa gct gtt gat atc atc aat ggt 1200 Leu Arg Ser Leu Ile Arg Thr Thr Gln Ala Val Asp Ile Ile Asn Gly 385 390 395 400 ggt gtt aaa gct aat gct ctg ccc gaa act acc aga ttc ttg atc aat 1248 Gly Val Lys Ala Asn Ala Leu Pro Glu Thr Thr Arg Phe Leu Ile Asn 405 410 415 cac aga att aat tta cat tct tct gtg gct gaa gtc ttt gaa aga aac 1296 His Arg Ile Asn Leu His Ser Ser Val Ala Glu Val Phe Glu Arg Asn 420 425 430 ata gaa tat gcg aaa aag att gct gag aag tat ggc tat ggt tta tct 1344 Ile Glu Tyr Ala Lys Lys Ile Ala Glu Lys Tyr Gly Tyr Gly Leu Ser 435 440 445 aag aac ggt gac gat tac att atc cct gaa acc gag tta ggt cac att 1392 Lys Asn Gly Asp Asp Tyr Ile Ile Pro Glu Thr Glu Leu Gly His Ile 450 455 460 gac att act ctc ttg aga gaa ttg gaa cca gca cca ctt tcg cca agt 1440 Asp Ile Thr Leu Leu Arg Glu Leu Glu Pro Ala Pro Leu Ser Pro Ser 465 470 475 480 Page 162 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tca ggc cct gtt tgg gac att ttg gca ggt act att caa gat gtt ttt 1488 Ser Gly Pro Val Trp Asp Ile Leu Ala Gly Thr Ile Gln Asp Val Phe 485 490 495 gaa aac ggt gtt cta caa aac aac gaa gag ttc tat gtg act act ggt 1536 Glu Asn Gly Val Leu Gln Asn Asn Glu Glu Phe Tyr Val Thr Thr Gly 500 505 510 tta ttc tct ggt aac acc gat act aaa tac tac tgg aat ttg tcc aag 1584 Leu Phe Ser Gly Asn Thr Asp Thr Lys Tyr Tyr Trp Asn Leu Ser Lys 515 520 525 aac att tat agg ttt gtt ggc tct atc att gat att gat tta ctg aag 1632 Asn Ile Tyr Arg Phe Val Gly Ser Ile Ile Asp Ile Asp Leu Leu Lys 530 535 540 aca ttg cat tcg gtt aat gaa cac gtg gat gtc cca ggt cat tta tct 1680 Thr Leu His Ser Val Asn Glu His Val Asp Val Pro Gly His Leu Ser 545 550 555 560 gcc att gcc ttt gtt tac gag tat atc gtt aat gtt aac gaa tac gct 1728 Ala Ile Ala Phe Val Tyr Glu Tyr Ile Val Asn Val Asn Glu Tyr Ala 565 570 575 taa 1731 <210> 109 <211> 576 <212> PRT <213> Saccharomyces cerevisiae <400> 109 Met Ile Ala Leu Pro Val Glu Lys Ala Pro Arg Lys Ser Leu Trp Gln 1 5 10 15 Arg His Arg Ala Phe Ile Ser Gly Ile Val Ala Leu Ile Ile Ile Gly 20 25 30 Thr Phe Phe Leu Thr Ser Gly Leu His Pro Ala Pro Pro His Glu Ala 35 40 45 Lys Arg Pro His His Gly Lys Gly Pro Met His Ser Pro Lys Cys Glu 50 55 60 Lys Ile Glu Pro Leu Ser Pro Ser Phe Lys His Ser Val Asp Thr Ile 65 70 75 80 Leu His Asp Pro Ala Phe Arg Asn Ser Ser Ile Glu Lys Leu Ser Asn 85 90 95 Ala Val Arg Ile Pro Thr Val Val Gln Asp Lys Asn Pro Asn Pro Ala 100 105 110 Asp Asp Pro Asp Phe Tyr Lys His Phe Tyr Glu Leu His Asp Tyr Phe 115 120 125 Glu Lys Thr Phe Pro Asn Ile His Lys His Leu Lys Leu Glu Lys Val 130 135 140 Page 163 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Glu Leu Gly Leu Leu Tyr Thr Trp Glu Gly Ser Asp Pro Asp Leu 145 150 155 160 Lys Pro Leu Leu Leu Met Ala His Gln Asp Val Val Pro Val Asn Asn 165 170 175 Glu Thr Leu Ser Ser Trp Lys Phe Pro Pro Phe Ser Gly His Tyr Asp 180 185 190 Pro Glu Thr Asp Phe Val Trp Gly Arg Gly Ser Asn Asp Cys Lys Asn 195 200 205 Leu Leu Ile Ala Glu Phe Glu Ala Ile Glu Gln Leu Leu Ile Asp Gly 210 215 220 Phe Lys Pro Asn Arg Thr Ile Val Met Ser Leu Gly Phe Asp Glu Glu 225 230 235 240 Ala Ser Gly Thr Leu Gly Ala Ala Ser Leu Ala Ser Phe Leu His Glu 245 250 255 Arg Tyr Gly Asp Asp Gly Ile Tyr Ser Ile Ile Asp Glu Gly Glu Gly 260 265 270 Ile Met Glu Val Asp Lys Asp Val Phe Val Ala Thr Pro Ile Asn Ala 275 280 285 Glu Lys Gly Tyr Val Asp Phe Glu Val Ser Ile Leu Gly His Gly Gly 290 295 300 His Ser Ser Val Pro Pro Asp His Thr Thr Ile Gly Ile Ala Ser Glu 305 310 315 320 Leu Ile Thr Glu Phe Glu Ala Asn Pro Phe Asp Tyr Glu Phe Glu Phe 325 330 335 Asp Asn Pro Ile Tyr Gly Leu Leu Thr Cys Ala Ala Glu His Ser Lys 340 345 350 Ser Leu Ser Lys Asp Val Lys Lys Thr Ile Leu Gly Ala Pro Phe Cys 355 360 365 Pro Arg Arg Lys Asp Lys Leu Val Glu Tyr Ile Ser Asn Gln Ser His 370 375 380 Leu Arg Ser Leu Ile Arg Thr Thr Gln Ala Val Asp Ile Ile Asn Gly 385 390 395 400 Gly Val Lys Ala Asn Ala Leu Pro Glu Thr Thr Arg Phe Leu Ile Asn 405 410 415 Page 164 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt His Arg Ile Asn Leu His Ser Ser Val Ala Glu Val Phe Glu Arg Asn 420 425 430 Ile Glu Tyr Ala Lys Lys Ile Ala Glu Lys Tyr Gly Tyr Gly Leu Ser 435 440 445 Lys Asn Gly Asp Asp Tyr Ile Ile Pro Glu Thr Glu Leu Gly His Ile 450 455 460 Asp Ile Thr Leu Leu Arg Glu Leu Glu Pro Ala Pro Leu Ser Pro Ser 465 470 475 480 Ser Gly Pro Val Trp Asp Ile Leu Ala Gly Thr Ile Gln Asp Val Phe 485 490 495 Glu Asn Gly Val Leu Gln Asn Asn Glu Glu Phe Tyr Val Thr Thr Gly 500 505 510 Leu Phe Ser Gly Asn Thr Asp Thr Lys Tyr Tyr Trp Asn Leu Ser Lys 515 520 525 Asn Ile Tyr Arg Phe Val Gly Ser Ile Ile Asp Ile Asp Leu Leu Lys 530 535 540 Thr Leu His Ser Val Asn Glu His Val Asp Val Pro Gly His Leu Ser 545 550 555 560 Ala Ile Ala Phe Val Tyr Glu Tyr Ile Val Asn Val Asn Glu Tyr Ala 565 570 575 <210> 110 <211> 1473 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1473) <400> 110 atg ttc agg ata caa ctg aga act atg tcc agc aaa aca tgc aag agt 48 Met Phe Arg Ile Gln Leu Arg Thr Met Ser Ser Lys Thr Cys Lys Ser 1 5 10 15 gat tac cca aag gag ttt gtc agt ttc tta aat agc tca cac tct cct 96 Asp Tyr Pro Lys Glu Phe Val Ser Phe Leu Asn Ser Ser His Ser Pro 20 25 30 tac cat aca gtt cat aac atc aaa aag cat ctg gtg tca aat ggc ttc 144 Tyr His Thr Val His Asn Ile Lys Lys His Leu Val Ser Asn Gly Phe 35 40 45 aaa gag ttg agc gaa cgt gac tcg tgg gct ggc cac gtc gca caa aaa 192 Lys Glu Leu Ser Glu Arg Asp Ser Trp Ala Gly His Val Ala Gln Lys 50 55 60 Page 165 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gga aag tac ttt gtg aca aga aat ggc tct tcc att att gcg ttt gct 240 Gly Lys Tyr Phe Val Thr Arg Asn Gly Ser Ser Ile Ile Ala Phe Ala 65 70 75 80 gtt ggt gga aag tgg gag cct ggt aat cca att gcc att acg ggt gct 288 Val Gly Gly Lys Trp Glu Pro Gly Asn Pro Ile Ala Ile Thr Gly Ala 85 90 95 cac acc gac tcc ccc gca tta agg att aag cct att tct aaa aga gtc 336 His Thr Asp Ser Pro Ala Leu Arg Ile Lys Pro Ile Ser Lys Arg Val 100 105 110 agt gag aag tat tta caa gtg ggc gtg gaa act tat ggt ggc gct att 384 Ser Glu Lys Tyr Leu Gln Val Gly Val Glu Thr Tyr Gly Gly Ala Ile 115 120 125 tgg cat tca tgg ttt gat aag gat ttg ggc gtt gcc gga aga gtt ttc 432 Trp His Ser Trp Phe Asp Lys Asp Leu Gly Val Ala Gly Arg Val Phe 130 135 140 gta aag gat gcg aaa act ggc aaa tcc att gct aga ttg gtg gat ttg 480 Val Lys Asp Ala Lys Thr Gly Lys Ser Ile Ala Arg Leu Val Asp Leu 145 150 155 160 aat aga cct ctg tta aag att cct act ttg gct att cat ctg gac aga 528 Asn Arg Pro Leu Leu Lys Ile Pro Thr Leu Ala Ile His Leu Asp Arg 165 170 175 gac gta aat caa aaa ttc gag ttt aat aga gaa act caa ctg ttg ccg 576 Asp Val Asn Gln Lys Phe Glu Phe Asn Arg Glu Thr Gln Leu Leu Pro 180 185 190 att ggt ggt ctg caa gaa gac aaa act gaa gcg aaa act gaa aag gaa 624 Ile Gly Gly Leu Gln Glu Asp Lys Thr Glu Ala Lys Thr Glu Lys Glu 195 200 205 att aat aac ggt gag ttt acc tcc ata aaa acg ata gta cag agg cat 672 Ile Asn Asn Gly Glu Phe Thr Ser Ile Lys Thr Ile Val Gln Arg His 210 215 220 cac gca gaa ctt ttg ggg cta ata gcc aaa gaa ctc gcc att gat aca 720 His Ala Glu Leu Leu Gly Leu Ile Ala Lys Glu Leu Ala Ile Asp Thr 225 230 235 240 att gaa gac att gaa gac ttc gaa ttg atc ctt tat gat cat aat gca 768 Ile Glu Asp Ile Glu Asp Phe Glu Leu Ile Leu Tyr Asp His Asn Ala 245 250 255 tcc act cta ggt ggg ttc aac gat gag ttt gtc ttc tct ggt cga ttg 816 Ser Thr Leu Gly Gly Phe Asn Asp Glu Phe Val Phe Ser Gly Arg Leu 260 265 270 gat aat ttg aca tct tgt ttc aca tca atg cac ggt tta acg ttg gcg 864 Asp Asn Leu Thr Ser Cys Phe Thr Ser Met His Gly Leu Thr Leu Ala 275 280 285 gct gac aca gaa att gac cga gaa tca ggc att aga ttg atg gca tgc 912 Ala Asp Thr Glu Ile Asp Arg Glu Ser Gly Ile Arg Leu Met Ala Cys 290 295 300 ttt gat cat gag gag att ggc tca tcc tcc gcc caa ggg gca gat tct 960 Phe Asp His Glu Glu Ile Gly Ser Ser Ser Ala Gln Gly Ala Asp Ser 305 310 315 320 aac ttc ttg cct aat ata ttg gaa agg ttg tcc atc ctg aag ggg gac 1008 Asn Phe Leu Pro Asn Ile Leu Glu Arg Leu Ser Ile Leu Lys Gly Asp 325 330 335 Page 166 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggt tct gat caa act aaa cct ttg ttt cac tcg gca ata ttg gaa act 1056 Gly Ser Asp Gln Thr Lys Pro Leu Phe His Ser Ala Ile Leu Glu Thr 340 345 350 tcc gct aag tcg ttt ttc ctt tca tct gat gtt gct cat gca gtt cat 1104 Ser Ala Lys Ser Phe Phe Leu Ser Ser Asp Val Ala His Ala Val His 355 360 365 cca aac tat gca aac aaa tac gaa agc caa cac aaa ccc tta ttg ggt 1152 Pro Asn Tyr Ala Asn Lys Tyr Glu Ser Gln His Lys Pro Leu Leu Gly 370 375 380 ggt ggt ccc gta atc aag att aac gcg aat caa cgt tac atg acc aat 1200 Gly Gly Pro Val Ile Lys Ile Asn Ala Asn Gln Arg Tyr Met Thr Asn 385 390 395 400 tca cca ggg ttg gtc ttg gtg aaa aga cta gca gag gct gct aaa gtc 1248 Ser Pro Gly Leu Val Leu Val Lys Arg Leu Ala Glu Ala Ala Lys Val 405 410 415 cct ttg caa ttg ttt gtc gta gct aac gac tca cca tgc ggt tct acc 1296 Pro Leu Gln Leu Phe Val Val Ala Asn Asp Ser Pro Cys Gly Ser Thr 420 425 430 atc ggc ccc att ttg gcc tca aag aca ggt att aga act cta gac ttg 1344 Ile Gly Pro Ile Leu Ala Ser Lys Thr Gly Ile Arg Thr Leu Asp Leu 435 440 445 ggt aat cct gtg ttg agt atg cat tcg att aga gag acc ggt ggc tct 1392 Gly Asn Pro Val Leu Ser Met His Ser Ile Arg Glu Thr Gly Gly Ser 450 455 460 gca gac ctg gag ttc caa atc aag tta ttt aag gaa ttt ttt gaa cgc 1440 Ala Asp Leu Glu Phe Gln Ile Lys Leu Phe Lys Glu Phe Phe Glu Arg 465 470 475 480 tac act tcc ata gaa tct gaa att gtt gtc taa 1473 Tyr Thr Ser Ile Glu Ser Glu Ile Val Val 485 490 <210> 111 <211> 490 <212> PRT <213> Saccharomyces cerevisiae <400> 111 Met Phe Arg Ile Gln Leu Arg Thr Met Ser Ser Lys Thr Cys Lys Ser 1 5 10 15 Asp Tyr Pro Lys Glu Phe Val Ser Phe Leu Asn Ser Ser His Ser Pro 20 25 30 Tyr His Thr Val His Asn Ile Lys Lys His Leu Val Ser Asn Gly Phe 35 40 45 Lys Glu Leu Ser Glu Arg Asp Ser Trp Ala Gly His Val Ala Gln Lys 50 55 60 Gly Lys Tyr Phe Val Thr Arg Asn Gly Ser Ser Ile Ile Ala Phe Ala 65 70 75 80 Page 167 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Gly Gly Lys Trp Glu Pro Gly Asn Pro Ile Ala Ile Thr Gly Ala 85 90 95 His Thr Asp Ser Pro Ala Leu Arg Ile Lys Pro Ile Ser Lys Arg Val 100 105 110 Ser Glu Lys Tyr Leu Gln Val Gly Val Glu Thr Tyr Gly Gly Ala Ile 115 120 125 Trp His Ser Trp Phe Asp Lys Asp Leu Gly Val Ala Gly Arg Val Phe 130 135 140 Val Lys Asp Ala Lys Thr Gly Lys Ser Ile Ala Arg Leu Val Asp Leu 145 150 155 160 Asn Arg Pro Leu Leu Lys Ile Pro Thr Leu Ala Ile His Leu Asp Arg 165 170 175 Asp Val Asn Gln Lys Phe Glu Phe Asn Arg Glu Thr Gln Leu Leu Pro 180 185 190 Ile Gly Gly Leu Gln Glu Asp Lys Thr Glu Ala Lys Thr Glu Lys Glu 195 200 205 Ile Asn Asn Gly Glu Phe Thr Ser Ile Lys Thr Ile Val Gln Arg His 210 215 220 His Ala Glu Leu Leu Gly Leu Ile Ala Lys Glu Leu Ala Ile Asp Thr 225 230 235 240 Ile Glu Asp Ile Glu Asp Phe Glu Leu Ile Leu Tyr Asp His Asn Ala 245 250 255 Ser Thr Leu Gly Gly Phe Asn Asp Glu Phe Val Phe Ser Gly Arg Leu 260 265 270 Asp Asn Leu Thr Ser Cys Phe Thr Ser Met His Gly Leu Thr Leu Ala 275 280 285 Ala Asp Thr Glu Ile Asp Arg Glu Ser Gly Ile Arg Leu Met Ala Cys 290 295 300 Phe Asp His Glu Glu Ile Gly Ser Ser Ser Ala Gln Gly Ala Asp Ser 305 310 315 320 Asn Phe Leu Pro Asn Ile Leu Glu Arg Leu Ser Ile Leu Lys Gly Asp 325 330 335 Gly Ser Asp Gln Thr Lys Pro Leu Phe His Ser Ala Ile Leu Glu Thr 340 345 350 Page 168 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Ala Lys Ser Phe Phe Leu Ser Ser Asp Val Ala His Ala Val His 355 360 365 Pro Asn Tyr Ala Asn Lys Tyr Glu Ser Gln His Lys Pro Leu Leu Gly 370 375 380 Gly Gly Pro Val Ile Lys Ile Asn Ala Asn Gln Arg Tyr Met Thr Asn 385 390 395 400 Ser Pro Gly Leu Val Leu Val Lys Arg Leu Ala Glu Ala Ala Lys Val 405 410 415 Pro Leu Gln Leu Phe Val Val Ala Asn Asp Ser Pro Cys Gly Ser Thr 420 425 430 Ile Gly Pro Ile Leu Ala Ser Lys Thr Gly Ile Arg Thr Leu Asp Leu 435 440 445 Gly Asn Pro Val Leu Ser Met His Ser Ile Arg Glu Thr Gly Gly Ser 450 455 460 Ala Asp Leu Glu Phe Gln Ile Lys Leu Phe Lys Glu Phe Phe Glu Arg 465 470 475 480 Tyr Thr Ser Ile Glu Ser Glu Ile Val Val 485 490 <210> 112 <211> 570 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(570) <400> 112 atg gat gat aag aaa aca tgg agt aca gtc act ttg aga acc ttc aat 48 Met Asp Asp Lys Lys Thr Trp Ser Thr Val Thr Leu Arg Thr Phe Asn 1 5 10 15 cag ctg gta acg tct tcg tta att gga tac tca aaa aag atg gat agc 96 Gln Leu Val Thr Ser Ser Leu Ile Gly Tyr Ser Lys Lys Met Asp Ser 20 25 30 atg aat cac aag atg gaa gga aat gcg ggc cac gac cac agt gat atg 144 Met Asn His Lys Met Glu Gly Asn Ala Gly His Asp His Ser Asp Met 35 40 45 cat atg gga gat gga gat gat acc tgt tcg atg aat atg cta ttt tcg 192 His Met Gly Asp Gly Asp Asp Thr Cys Ser Met Asn Met Leu Phe Ser 50 55 60 tgg tca tac aag aat acg tgt gtc gtc ttt gaa tgg tgg cat atc aag 240 Trp Ser Tyr Lys Asn Thr Cys Val Val Phe Glu Trp Trp His Ile Lys 65 70 75 80 Page 169 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt acc ctg cct gga ctg att tta agt tgt tta gca att ttt ggt cta gcc 288 Thr Leu Pro Gly Leu Ile Leu Ser Cys Leu Ala Ile Phe Gly Leu Ala 85 90 95 tac ctc tat gag tac tta aag tac tgt gtc cat aag aga caa tta tcc 336 Tyr Leu Tyr Glu Tyr Leu Lys Tyr Cys Val His Lys Arg Gln Leu Ser 100 105 110 cag aga gta ttg tta cca aat aga tct ctg acc aag atc aac caa gcc 384 Gln Arg Val Leu Leu Pro Asn Arg Ser Leu Thr Lys Ile Asn Gln Ala 115 120 125 gac aaa gtg tcc aat agt att cta tat ggt ttg caa gtg gga ttc tca 432 Asp Lys Val Ser Asn Ser Ile Leu Tyr Gly Leu Gln Val Gly Phe Ser 130 135 140 ttc atg ctc atg ctt gta ttc atg act tat aat ggt tgg tta atg tta 480 Phe Met Leu Met Leu Val Phe Met Thr Tyr Asn Gly Trp Leu Met Leu 145 150 155 160 gct gtc gtg tgt ggg gca ata tgg ggt aat tac agc tgg tgt act tcg 528 Ala Val Val Cys Gly Ala Ile Trp Gly Asn Tyr Ser Trp Cys Thr Ser 165 170 175 tat agt cct gag ata gat gac agc tcc ctc gcc tgc cat taa 570 Tyr Ser Pro Glu Ile Asp Asp Ser Ser Leu Ala Cys His 180 185 <210> 113 <211> 189 <212> PRT <213> Saccharomyces cerevisiae <400> 113 Met Asp Asp Lys Lys Thr Trp Ser Thr Val Thr Leu Arg Thr Phe Asn 1 5 10 15 Gln Leu Val Thr Ser Ser Leu Ile Gly Tyr Ser Lys Lys Met Asp Ser 20 25 30 Met Asn His Lys Met Glu Gly Asn Ala Gly His Asp His Ser Asp Met 35 40 45 His Met Gly Asp Gly Asp Asp Thr Cys Ser Met Asn Met Leu Phe Ser 50 55 60 Trp Ser Tyr Lys Asn Thr Cys Val Val Phe Glu Trp Trp His Ile Lys 65 70 75 80 Thr Leu Pro Gly Leu Ile Leu Ser Cys Leu Ala Ile Phe Gly Leu Ala 85 90 95 Tyr Leu Tyr Glu Tyr Leu Lys Tyr Cys Val His Lys Arg Gln Leu Ser 100 105 110 Gln Arg Val Leu Leu Pro Asn Arg Ser Leu Thr Lys Ile Asn Gln Ala 115 120 125 Page 170 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Lys Val Ser Asn Ser Ile Leu Tyr Gly Leu Gln Val Gly Phe Ser 130 135 140 Phe Met Leu Met Leu Val Phe Met Thr Tyr Asn Gly Trp Leu Met Leu 145 150 155 160 Ala Val Val Cys Gly Ala Ile Trp Gly Asn Tyr Ser Trp Cys Thr Ser 165 170 175 Tyr Ser Pro Glu Ile Asp Asp Ser Ser Leu Ala Cys His 180 185 <210> 114 <211> 585 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(585) <400> 114 atg att cat gca gtt cta ata ttc aat aag aaa tgc caa cca aga tta 48 Met Ile His Ala Val Leu Ile Phe Asn Lys Lys Cys Gln Pro Arg Leu 1 5 10 15 gtg aaa ttc tac acg ccg gtc gac ctt cca aag caa aaa ctg cta tta 96 Val Lys Phe Tyr Thr Pro Val Asp Leu Pro Lys Gln Lys Leu Leu Leu 20 25 30 gag caa gta tat gaa ttg att tct caa agg aat agc gat ttt caa agt 144 Glu Gln Val Tyr Glu Leu Ile Ser Gln Arg Asn Ser Asp Phe Gln Ser 35 40 45 tct ttt tta gtc acg cca cca tcg ctt ctg tta agc aat gaa aat aat 192 Ser Phe Leu Val Thr Pro Pro Ser Leu Leu Leu Ser Asn Glu Asn Asn 50 55 60 aat gat gag gta aac aat gaa gat att caa atc atc tat aaa aac tac 240 Asn Asp Glu Val Asn Asn Glu Asp Ile Gln Ile Ile Tyr Lys Asn Tyr 65 70 75 80 gct aca cta tat ttc act ttc atc gtg gat gat caa gaa tca gaa ctg 288 Ala Thr Leu Tyr Phe Thr Phe Ile Val Asp Asp Gln Glu Ser Glu Leu 85 90 95 gcc ata tta gat ctg atc caa act ttt gtg gaa tca ttg gac cgt tgt 336 Ala Ile Leu Asp Leu Ile Gln Thr Phe Val Glu Ser Leu Asp Arg Cys 100 105 110 ttt act gaa gtc aat gaa ctt gat ttg att ttt aac tgg caa act ttg 384 Phe Thr Glu Val Asn Glu Leu Asp Leu Ile Phe Asn Trp Gln Thr Leu 115 120 125 gaa agt gta tta gaa gaa atc gtg cag ggg ggc atg gtc att gaa aca 432 Glu Ser Val Leu Glu Glu Ile Val Gln Gly Gly Met Val Ile Glu Thr 130 135 140 aat gtg aac aga ata gtt gct tct gtt gac gaa ctc aac aaa gct gcc 480 Asn Val Asn Arg Ile Val Ala Ser Val Asp Glu Leu Asn Lys Ala Ala 145 150 155 160 gag tcc aca gat agt aaa att gga aga cta acg tcc act gga ttt gga 528 Page 171 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Ser Thr Asp Ser Lys Ile Gly Arg Leu Thr Ser Thr Gly Phe Gly 165 170 175 agc gca cta caa gcg ttt gct caa ggc gga ttt gca caa tgg gca acg 576 Ser Ala Leu Gln Ala Phe Ala Gln Gly Gly Phe Ala Gln Trp Ala Thr 180 185 190 ggg caa taa 585 Gly Gln <210> 115 <211> 194 <212> PRT <213> Saccharomyces cerevisiae <400> 115 Met Ile His Ala Val Leu Ile Phe Asn Lys Lys Cys Gln Pro Arg Leu 1 5 10 15 Val Lys Phe Tyr Thr Pro Val Asp Leu Pro Lys Gln Lys Leu Leu Leu 20 25 30 Glu Gln Val Tyr Glu Leu Ile Ser Gln Arg Asn Ser Asp Phe Gln Ser 35 40 45 Ser Phe Leu Val Thr Pro Pro Ser Leu Leu Leu Ser Asn Glu Asn Asn 50 55 60 Asn Asp Glu Val Asn Asn Glu Asp Ile Gln Ile Ile Tyr Lys Asn Tyr 65 70 75 80 Ala Thr Leu Tyr Phe Thr Phe Ile Val Asp Asp Gln Glu Ser Glu Leu 85 90 95 Ala Ile Leu Asp Leu Ile Gln Thr Phe Val Glu Ser Leu Asp Arg Cys 100 105 110 Phe Thr Glu Val Asn Glu Leu Asp Leu Ile Phe Asn Trp Gln Thr Leu 115 120 125 Glu Ser Val Leu Glu Glu Ile Val Gln Gly Gly Met Val Ile Glu Thr 130 135 140 Asn Val Asn Arg Ile Val Ala Ser Val Asp Glu Leu Asn Lys Ala Ala 145 150 155 160 Glu Ser Thr Asp Ser Lys Ile Gly Arg Leu Thr Ser Thr Gly Phe Gly 165 170 175 Ser Ala Leu Gln Ala Phe Ala Gln Gly Gly Phe Ala Gln Trp Ala Thr 180 185 190 Gly Gln Page 172 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 116 <211> 1038 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1038) <400> 116 atg gaa gca cat aac caa ttt ttg aag act ttc caa aaa gaa cgt cat 48 Met Glu Ala His Asn Gln Phe Leu Lys Thr Phe Gln Lys Glu Arg His 1 5 10 15 gat atg aaa gaa gct gaa aag gat gaa atc ctt ttg atg gaa aac agc 96 Asp Met Lys Glu Ala Glu Lys Asp Glu Ile Leu Leu Met Glu Asn Ser 20 25 30 cgt aga ttc gtg atg ttc cct atc aaa tac cac gaa atc tgg gct gct 144 Arg Arg Phe Val Met Phe Pro Ile Lys Tyr His Glu Ile Trp Ala Ala 35 40 45 tac aag aag gtt gaa gcc tct ttc tgg act gcg gaa gaa atc gaa ttg 192 Tyr Lys Lys Val Glu Ala Ser Phe Trp Thr Ala Glu Glu Ile Glu Leu 50 55 60 gct aag gac act gaa gat ttc caa aaa ttg act gat gac cag aag acc 240 Ala Lys Asp Thr Glu Asp Phe Gln Lys Leu Thr Asp Asp Gln Lys Thr 65 70 75 80 tac atc ggt aac ttg tta gcc ttg tcc att tct tct gac aac ctt gtc 288 Tyr Ile Gly Asn Leu Leu Ala Leu Ser Ile Ser Ser Asp Asn Leu Val 85 90 95 aac aag tac ttg atc gaa aac ttt tct gcc caa ttg caa aac cct gaa 336 Asn Lys Tyr Leu Ile Glu Asn Phe Ser Ala Gln Leu Gln Asn Pro Glu 100 105 110 ggt aag agt ttc tac ggg ttc cag att atg atg gaa aac atc tac tct 384 Gly Lys Ser Phe Tyr Gly Phe Gln Ile Met Met Glu Asn Ile Tyr Ser 115 120 125 gaa gtt tac tcc atg atg gtt gat gcc ttc ttc aag gac cct aag aac 432 Glu Val Tyr Ser Met Met Val Asp Ala Phe Phe Lys Asp Pro Lys Asn 130 135 140 atc cct cta ttc aag gaa att gcc aat ttg cct gaa gtc aag cat aag 480 Ile Pro Leu Phe Lys Glu Ile Ala Asn Leu Pro Glu Val Lys His Lys 145 150 155 160 gct gct ttc atc gag aga tgg att tcc aac gat gac agc ttg tat gct 528 Ala Ala Phe Ile Glu Arg Trp Ile Ser Asn Asp Asp Ser Leu Tyr Ala 165 170 175 gaa aga cta gta gca ttt gct gca aag gaa ggt att ttc caa gct ggt 576 Glu Arg Leu Val Ala Phe Ala Ala Lys Glu Gly Ile Phe Gln Ala Gly 180 185 190 aac tat gct tct atg ttc tgg ttg act gac aaa aag att atg cca ggt 624 Asn Tyr Ala Ser Met Phe Trp Leu Thr Asp Lys Lys Ile Met Pro Gly 195 200 205 tta gca atg gcc aac aga aac atc tgt aga gac aga ggt gcc tac act 672 Leu Ala Met Ala Asn Arg Asn Ile Cys Arg Asp Arg Gly Ala Tyr Thr Page 173 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 210 215 220 gac ttt tca tgc ttg cta ttt gcc cat ttg aga acc aag cca aac ccc 720 Asp Phe Ser Cys Leu Leu Phe Ala His Leu Arg Thr Lys Pro Asn Pro 225 230 235 240 aag atc att gaa aaa atc att acc gaa gcc gtg gaa att gaa aag gaa 768 Lys Ile Ile Glu Lys Ile Ile Thr Glu Ala Val Glu Ile Glu Lys Glu 245 250 255 tac tac tca aac tct ttg cca gta gaa aaa ttt ggt atg gat ttg aag 816 Tyr Tyr Ser Asn Ser Leu Pro Val Glu Lys Phe Gly Met Asp Leu Lys 260 265 270 agc att cac acc tac ata gaa ttt gtc gct gac ggt cta tta caa ggt 864 Ser Ile His Thr Tyr Ile Glu Phe Val Ala Asp Gly Leu Leu Gln Gly 275 280 285 ttc ggt aac gaa aaa tac tac aac gcc gtc aac cca ttc gaa ttc atg 912 Phe Gly Asn Glu Lys Tyr Tyr Asn Ala Val Asn Pro Phe Glu Phe Met 290 295 300 gag gat gtc gct acc gct ggt aag acc acc ttc ttt gaa aag aag gtt 960 Glu Asp Val Ala Thr Ala Gly Lys Thr Thr Phe Phe Glu Lys Lys Val 305 310 315 320 tcc gac tac caa aag gcc agt gac atg tct aag tcc gct acc cca tcc 1008 Ser Asp Tyr Gln Lys Ala Ser Asp Met Ser Lys Ser Ala Thr Pro Ser 325 330 335 aag gaa att aac ttt gat gat gac ttc taa 1038 Lys Glu Ile Asn Phe Asp Asp Asp Phe 340 345 <210> 117 <211> 345 <212> PRT <213> Saccharomyces cerevisiae <400> 117 Met Glu Ala His Asn Gln Phe Leu Lys Thr Phe Gln Lys Glu Arg His 1 5 10 15 Asp Met Lys Glu Ala Glu Lys Asp Glu Ile Leu Leu Met Glu Asn Ser 20 25 30 Arg Arg Phe Val Met Phe Pro Ile Lys Tyr His Glu Ile Trp Ala Ala 35 40 45 Tyr Lys Lys Val Glu Ala Ser Phe Trp Thr Ala Glu Glu Ile Glu Leu 50 55 60 Ala Lys Asp Thr Glu Asp Phe Gln Lys Leu Thr Asp Asp Gln Lys Thr 65 70 75 80 Tyr Ile Gly Asn Leu Leu Ala Leu Ser Ile Ser Ser Asp Asn Leu Val 85 90 95 Asn Lys Tyr Leu Ile Glu Asn Phe Ser Ala Gln Leu Gln Asn Pro Glu 100 105 110 Page 174 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Lys Ser Phe Tyr Gly Phe Gln Ile Met Met Glu Asn Ile Tyr Ser 115 120 125 Glu Val Tyr Ser Met Met Val Asp Ala Phe Phe Lys Asp Pro Lys Asn 130 135 140 Ile Pro Leu Phe Lys Glu Ile Ala Asn Leu Pro Glu Val Lys His Lys 145 150 155 160 Ala Ala Phe Ile Glu Arg Trp Ile Ser Asn Asp Asp Ser Leu Tyr Ala 165 170 175 Glu Arg Leu Val Ala Phe Ala Ala Lys Glu Gly Ile Phe Gln Ala Gly 180 185 190 Asn Tyr Ala Ser Met Phe Trp Leu Thr Asp Lys Lys Ile Met Pro Gly 195 200 205 Leu Ala Met Ala Asn Arg Asn Ile Cys Arg Asp Arg Gly Ala Tyr Thr 210 215 220 Asp Phe Ser Cys Leu Leu Phe Ala His Leu Arg Thr Lys Pro Asn Pro 225 230 235 240 Lys Ile Ile Glu Lys Ile Ile Thr Glu Ala Val Glu Ile Glu Lys Glu 245 250 255 Tyr Tyr Ser Asn Ser Leu Pro Val Glu Lys Phe Gly Met Asp Leu Lys 260 265 270 Ser Ile His Thr Tyr Ile Glu Phe Val Ala Asp Gly Leu Leu Gln Gly 275 280 285 Phe Gly Asn Glu Lys Tyr Tyr Asn Ala Val Asn Pro Phe Glu Phe Met 290 295 300 Glu Asp Val Ala Thr Ala Gly Lys Thr Thr Phe Phe Glu Lys Lys Val 305 310 315 320 Ser Asp Tyr Gln Lys Ala Ser Asp Met Ser Lys Ser Ala Thr Pro Ser 325 330 335 Lys Glu Ile Asn Phe Asp Asp Asp Phe 340 345 <210> 118 <211> 330 <212> DNA <213> Saccharomyces cerevisiae Page 175 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(330) <400> 118 atg tca cag ata gca caa gaa atg aca gtg agc tta aga aac gcc agg 48 Met Ser Gln Ile Ala Gln Glu Met Thr Val Ser Leu Arg Asn Ala Arg 1 5 10 15 aca caa ttg gat atg gtc aat cag cag cta gca tat ttg gac aga caa 96 Thr Gln Leu Asp Met Val Asn Gln Gln Leu Ala Tyr Leu Asp Arg Gln 20 25 30 gaa aag ctt gct gaa ttg aca aag aaa gaa cta gag tct tat cca acg 144 Glu Lys Leu Ala Glu Leu Thr Lys Lys Glu Leu Glu Ser Tyr Pro Thr 35 40 45 gac aaa gta tgg aga tct tgc ggt aaa tcg ttt atc tta cag gat aaa 192 Asp Lys Val Trp Arg Ser Cys Gly Lys Ser Phe Ile Leu Gln Asp Lys 50 55 60 tcc aaa tac gtt aat gat tta tca cat gcc gaa act gtt ctt ctg gat 240 Ser Lys Tyr Val Asn Asp Leu Ser His Ala Glu Thr Val Leu Leu Asp 65 70 75 80 caa aga aaa aca tta aag ata aag aag aac tat tta gaa act act gtt 288 Gln Arg Lys Thr Leu Lys Ile Lys Lys Asn Tyr Leu Glu Thr Thr Val 85 90 95 gaa aaa aca ata gac aat cta aag gca ttg atg aag aat taa 330 Glu Lys Thr Ile Asp Asn Leu Lys Ala Leu Met Lys Asn 100 105 <210> 119 <211> 109 <212> PRT <213> Saccharomyces cerevisiae <400> 119 Met Ser Gln Ile Ala Gln Glu Met Thr Val Ser Leu Arg Asn Ala Arg 1 5 10 15 Thr Gln Leu Asp Met Val Asn Gln Gln Leu Ala Tyr Leu Asp Arg Gln 20 25 30 Glu Lys Leu Ala Glu Leu Thr Lys Lys Glu Leu Glu Ser Tyr Pro Thr 35 40 45 Asp Lys Val Trp Arg Ser Cys Gly Lys Ser Phe Ile Leu Gln Asp Lys 50 55 60 Ser Lys Tyr Val Asn Asp Leu Ser His Ala Glu Thr Val Leu Leu Asp 65 70 75 80 Gln Arg Lys Thr Leu Lys Ile Lys Lys Asn Tyr Leu Glu Thr Thr Val 85 90 95 Glu Lys Thr Ile Asp Asn Leu Lys Ala Leu Met Lys Asn 100 105 Page 176 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 120 <211> 648 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(648) <400> 120 atg aat gga att caa gtg gac atc aat cgt ttg aaa aag ggc gaa gtc 48 Met Asn Gly Ile Gln Val Asp Ile Asn Arg Leu Lys Lys Gly Glu Val 1 5 10 15 agt tta ggt acc tca att atg gcc gtg aca ttt aag gat ggt gtg ata 96 Ser Leu Gly Thr Ser Ile Met Ala Val Thr Phe Lys Asp Gly Val Ile 20 25 30 cta ggt gct gat tca cgt acc acc act ggt gcg tac ata gct aac cgt 144 Leu Gly Ala Asp Ser Arg Thr Thr Thr Gly Ala Tyr Ile Ala Asn Arg 35 40 45 gtg aca gat aaa tta acg aga gta cat gac aaa att tgg tgt tgt agg 192 Val Thr Asp Lys Leu Thr Arg Val His Asp Lys Ile Trp Cys Cys Arg 50 55 60 tcc ggt tct gca gca gac acg cag gcg att gcc gac att gtt cag tac 240 Ser Gly Ser Ala Ala Asp Thr Gln Ala Ile Ala Asp Ile Val Gln Tyr 65 70 75 80 cat ttg gaa tta tat act tct caa tat ggt acc ccc tcc aca gag act 288 His Leu Glu Leu Tyr Thr Ser Gln Tyr Gly Thr Pro Ser Thr Glu Thr 85 90 95 gct gcc tcg gtg ttc aaa gaa tta tgt tac gaa aat aaa gat aac ctt 336 Ala Ala Ser Val Phe Lys Glu Leu Cys Tyr Glu Asn Lys Asp Asn Leu 100 105 110 act gct ggt ata att gtg gct ggt tat gat gac aaa aac aaa ggg gaa 384 Thr Ala Gly Ile Ile Val Ala Gly Tyr Asp Asp Lys Asn Lys Gly Glu 115 120 125 gta tat act att cca ttg ggt ggc tcc gtc cat aag ctg cct tat gcg 432 Val Tyr Thr Ile Pro Leu Gly Gly Ser Val His Lys Leu Pro Tyr Ala 130 135 140 ata gca gga tct ggc tct act ttc ata tat ggg tat tgt gat aaa aac 480 Ile Ala Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Cys Asp Lys Asn 145 150 155 160 ttt aga gaa aat atg tca aag gaa gaa acc gta gat ttc ata aag cat 528 Phe Arg Glu Asn Met Ser Lys Glu Glu Thr Val Asp Phe Ile Lys His 165 170 175 tcg cta tcg caa gcc att aaa tgg gac gga tct tcc ggt ggt gtt ata 576 Ser Leu Ser Gln Ala Ile Lys Trp Asp Gly Ser Ser Gly Gly Val Ile 180 185 190 aga atg gtt gtt ttg aca gct gct ggt gtg gaa cgt ttg ata ttc tac 624 Arg Met Val Val Leu Thr Ala Ala Gly Val Glu Arg Leu Ile Phe Tyr 195 200 205 cct gat gaa tat gaa caa cta taa 648 Pro Asp Glu Tyr Glu Gln Leu 210 215 Page 177 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 121 <211> 215 <212> PRT <213> Saccharomyces cerevisiae <400> 121 Met Asn Gly Ile Gln Val Asp Ile Asn Arg Leu Lys Lys Gly Glu Val 1 5 10 15 Ser Leu Gly Thr Ser Ile Met Ala Val Thr Phe Lys Asp Gly Val Ile 20 25 30 Leu Gly Ala Asp Ser Arg Thr Thr Thr Gly Ala Tyr Ile Ala Asn Arg 35 40 45 Val Thr Asp Lys Leu Thr Arg Val His Asp Lys Ile Trp Cys Cys Arg 50 55 60 Ser Gly Ser Ala Ala Asp Thr Gln Ala Ile Ala Asp Ile Val Gln Tyr 65 70 75 80 His Leu Glu Leu Tyr Thr Ser Gln Tyr Gly Thr Pro Ser Thr Glu Thr 85 90 95 Ala Ala Ser Val Phe Lys Glu Leu Cys Tyr Glu Asn Lys Asp Asn Leu 100 105 110 Thr Ala Gly Ile Ile Val Ala Gly Tyr Asp Asp Lys Asn Lys Gly Glu 115 120 125 Val Tyr Thr Ile Pro Leu Gly Gly Ser Val His Lys Leu Pro Tyr Ala 130 135 140 Ile Ala Gly Ser Gly Ser Thr Phe Ile Tyr Gly Tyr Cys Asp Lys Asn 145 150 155 160 Phe Arg Glu Asn Met Ser Lys Glu Glu Thr Val Asp Phe Ile Lys His 165 170 175 Ser Leu Ser Gln Ala Ile Lys Trp Asp Gly Ser Ser Gly Gly Val Ile 180 185 190 Arg Met Val Val Leu Thr Ala Ala Gly Val Glu Arg Leu Ile Phe Tyr 195 200 205 Pro Asp Glu Tyr Glu Gln Leu 210 215 <210> 122 <211> 990 <212> DNA <213> Saccharomyces cerevisiae Page 178 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(990) <400> 122 atg tgc agt agg ata ctc ttg tcc ggt tta gtc gga ctg ggt gct ggt 48 Met Cys Ser Arg Ile Leu Leu Ser Gly Leu Val Gly Leu Gly Ala Gly 1 5 10 15 act ggc tta acc tat ctt ctt ttg aac aaa cat tct cca acg caa atc 96 Thr Gly Leu Thr Tyr Leu Leu Leu Asn Lys His Ser Pro Thr Gln Ile 20 25 30 att gag aca cct tat cca cct acc cag aaa cct aat agt aat att caa 144 Ile Glu Thr Pro Tyr Pro Pro Thr Gln Lys Pro Asn Ser Asn Ile Gln 35 40 45 tct cac tct ttc aac gtc gat cct tcc ggg ttc ttc aag tat ggt ttt 192 Ser His Ser Phe Asn Val Asp Pro Ser Gly Phe Phe Lys Tyr Gly Phe 50 55 60 cct ggt ccg att cat gat ctg cag aac cgc gaa gag ttt atc tca tgt 240 Pro Gly Pro Ile His Asp Leu Gln Asn Arg Glu Glu Phe Ile Ser Cys 65 70 75 80 tac aac aga caa act caa aat cct tat tgg gtc ctc gaa cat ata acg 288 Tyr Asn Arg Gln Thr Gln Asn Pro Tyr Trp Val Leu Glu His Ile Thr 85 90 95 cca gaa tca ttg gct gca agg aat gct gac aga aaa aat tcc ttt ttc 336 Pro Glu Ser Leu Ala Ala Arg Asn Ala Asp Arg Lys Asn Ser Phe Phe 100 105 110 aag gaa gat gaa gta att cca gaa aag ttt aga ggt aaa cta aga gac 384 Lys Glu Asp Glu Val Ile Pro Glu Lys Phe Arg Gly Lys Leu Arg Asp 115 120 125 tat ttt agg tcg ggc tat gat cga ggc cat caa gcc cca gct gca gac 432 Tyr Phe Arg Ser Gly Tyr Asp Arg Gly His Gln Ala Pro Ala Ala Asp 130 135 140 gca aaa ttt tct caa cag gcc atg gat gat aca ttc tac tta tcc aat 480 Ala Lys Phe Ser Gln Gln Ala Met Asp Asp Thr Phe Tyr Leu Ser Asn 145 150 155 160 atg tgt cct caa gta gga gaa ggt ttt aat aga gac tat tgg gcg cat 528 Met Cys Pro Gln Val Gly Glu Gly Phe Asn Arg Asp Tyr Trp Ala His 165 170 175 ttg gag tac ttt tgt agg gga ttg act aag aaa tat aag agt gta aga 576 Leu Glu Tyr Phe Cys Arg Gly Leu Thr Lys Lys Tyr Lys Ser Val Arg 180 185 190 atc gtg act ggt cca ttg tat cta ccc aaa aag gat ccc ata gat aat 624 Ile Val Thr Gly Pro Leu Tyr Leu Pro Lys Lys Asp Pro Ile Asp Asn 195 200 205 aaa ttt agg gtt aat tat gaa gtt att ggc aat cca ccc agt att gct 672 Lys Phe Arg Val Asn Tyr Glu Val Ile Gly Asn Pro Pro Ser Ile Ala 210 215 220 gtt cca acg cac ttt ttt aaa ttg att gtt gca gaa gca cca aca gcc 720 Val Pro Thr His Phe Phe Lys Leu Ile Val Ala Glu Ala Pro Thr Ala 225 230 235 240 aat cct gct aga gag gat att gct gtc gcg gca ttt gta ttg cca aac 768 Page 179 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Pro Ala Arg Glu Asp Ile Ala Val Ala Ala Phe Val Leu Pro Asn 245 250 255 gaa ccg ata tca aat gag acg aaa ttg act gac ttt gaa gtt cct ata 816 Glu Pro Ile Ser Asn Glu Thr Lys Leu Thr Asp Phe Glu Val Pro Ile 260 265 270 gat gct tta gag aga agt act ggg cta gaa ctt ctg caa aaa gta cca 864 Asp Ala Leu Glu Arg Ser Thr Gly Leu Glu Leu Leu Gln Lys Val Pro 275 280 285 cct tca aag aag aag gca tta tgc aaa gag gta aat tgt caa att gta 912 Pro Ser Lys Lys Lys Ala Leu Cys Lys Glu Val Asn Cys Gln Ile Val 290 295 300 gtg aga gat ttc tct aac gcg gcg atc aaa caa tcg aaa gat gtg aaa 960 Val Arg Asp Phe Ser Asn Ala Ala Ile Lys Gln Ser Lys Asp Val Lys 305 310 315 320 ttg tta cct cct cca aaa aaa agg aat tga 990 Leu Leu Pro Pro Pro Lys Lys Arg Asn 325 <210> 123 <211> 329 <212> PRT <213> Saccharomyces cerevisiae <400> 123 Met Cys Ser Arg Ile Leu Leu Ser Gly Leu Val Gly Leu Gly Ala Gly 1 5 10 15 Thr Gly Leu Thr Tyr Leu Leu Leu Asn Lys His Ser Pro Thr Gln Ile 20 25 30 Ile Glu Thr Pro Tyr Pro Pro Thr Gln Lys Pro Asn Ser Asn Ile Gln 35 40 45 Ser His Ser Phe Asn Val Asp Pro Ser Gly Phe Phe Lys Tyr Gly Phe 50 55 60 Pro Gly Pro Ile His Asp Leu Gln Asn Arg Glu Glu Phe Ile Ser Cys 65 70 75 80 Tyr Asn Arg Gln Thr Gln Asn Pro Tyr Trp Val Leu Glu His Ile Thr 85 90 95 Pro Glu Ser Leu Ala Ala Arg Asn Ala Asp Arg Lys Asn Ser Phe Phe 100 105 110 Lys Glu Asp Glu Val Ile Pro Glu Lys Phe Arg Gly Lys Leu Arg Asp 115 120 125 Tyr Phe Arg Ser Gly Tyr Asp Arg Gly His Gln Ala Pro Ala Ala Asp 130 135 140 Ala Lys Phe Ser Gln Gln Ala Met Asp Asp Thr Phe Tyr Leu Ser Asn Page 180 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 Met Cys Pro Gln Val Gly Glu Gly Phe Asn Arg Asp Tyr Trp Ala His 165 170 175 Leu Glu Tyr Phe Cys Arg Gly Leu Thr Lys Lys Tyr Lys Ser Val Arg 180 185 190 Ile Val Thr Gly Pro Leu Tyr Leu Pro Lys Lys Asp Pro Ile Asp Asn 195 200 205 Lys Phe Arg Val Asn Tyr Glu Val Ile Gly Asn Pro Pro Ser Ile Ala 210 215 220 Val Pro Thr His Phe Phe Lys Leu Ile Val Ala Glu Ala Pro Thr Ala 225 230 235 240 Asn Pro Ala Arg Glu Asp Ile Ala Val Ala Ala Phe Val Leu Pro Asn 245 250 255 Glu Pro Ile Ser Asn Glu Thr Lys Leu Thr Asp Phe Glu Val Pro Ile 260 265 270 Asp Ala Leu Glu Arg Ser Thr Gly Leu Glu Leu Leu Gln Lys Val Pro 275 280 285 Pro Ser Lys Lys Lys Ala Leu Cys Lys Glu Val Asn Cys Gln Ile Val 290 295 300 Val Arg Asp Phe Ser Asn Ala Ala Ile Lys Gln Ser Lys Asp Val Lys 305 310 315 320 Leu Leu Pro Pro Pro Lys Lys Arg Asn 325 <210> 124 <211> 360 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(360) <400> 124 atg ccg cat tta gcc gcc gaa gcg cat act tgg cct ccg cat att tca 48 Met Pro His Leu Ala Ala Glu Ala His Thr Trp Pro Pro His Ile Ser 1 5 10 15 cat tca aca ctt tcg att ccg cat cca acc ccg gaa cac cgg cac gta 96 His Ser Thr Leu Ser Ile Pro His Pro Thr Pro Glu His Arg His Val 20 25 30 ttt cat aaa aag gac gtg aag aac aaa agg aac gaa gaa aaa ggc aat 144 Phe His Lys Lys Asp Val Lys Asn Lys Arg Asn Glu Glu Lys Gly Asn Page 181 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 35 40 45 aat tta ctc tat gtg tta ttt aga act acg gtg ata aag agc tcg ttc 192 Asn Leu Leu Tyr Val Leu Phe Arg Thr Thr Val Ile Lys Ser Ser Phe 50 55 60 cga tca cta agt acg gcc gga aga gag ctg ttg ttt gtt gtc cat caa 240 Arg Ser Leu Ser Thr Ala Gly Arg Glu Leu Leu Phe Val Val His Gln 65 70 75 80 ggg cac atc ggc acc ggc ctc atc gtc ttc atc ata tgc tgg agg ctg 288 Gly His Ile Gly Thr Gly Leu Ile Val Phe Ile Ile Cys Trp Arg Leu 85 90 95 tgc ttg aga ttc ctc tgc agg gtg agc ttc cag gtc acg gtc tac ggc 336 Cys Leu Arg Phe Leu Cys Arg Val Ser Phe Gln Val Thr Val Tyr Gly 100 105 110 ggg cgc agt cgc atg tct gcg tga 360 Gly Arg Ser Arg Met Ser Ala 115 <210> 125 <211> 119 <212> PRT <213> Saccharomyces cerevisiae <400> 125 Met Pro His Leu Ala Ala Glu Ala His Thr Trp Pro Pro His Ile Ser 1 5 10 15 His Ser Thr Leu Ser Ile Pro His Pro Thr Pro Glu His Arg His Val 20 25 30 Phe His Lys Lys Asp Val Lys Asn Lys Arg Asn Glu Glu Lys Gly Asn 35 40 45 Asn Leu Leu Tyr Val Leu Phe Arg Thr Thr Val Ile Lys Ser Ser Phe 50 55 60 Arg Ser Leu Ser Thr Ala Gly Arg Glu Leu Leu Phe Val Val His Gln 65 70 75 80 Gly His Ile Gly Thr Gly Leu Ile Val Phe Ile Ile Cys Trp Arg Leu 85 90 95 Cys Leu Arg Phe Leu Cys Arg Val Ser Phe Gln Val Thr Val Tyr Gly 100 105 110 Gly Arg Ser Arg Met Ser Ala 115 <210> 126 <211> 1071 <212> DNA <213> Saccharomyces cerevisiae Page 182 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(1071) <400> 126 atg tta aaa gtt cct ttg agt gat gtt ctt tca cag aag atg ctg ttt 48 Met Leu Lys Val Pro Leu Ser Asp Val Leu Ser Gln Lys Met Leu Phe 1 5 10 15 tta aaa agt ttt aga tat ttt cat tgc aca aaa tac ttc agc aga gac 96 Leu Lys Ser Phe Arg Tyr Phe His Cys Thr Lys Tyr Phe Ser Arg Asp 20 25 30 aat gca tca tct acc aca gat ata ttt cgc aac gca atg aaa cgt aaa 144 Asn Ala Ser Ser Thr Thr Asp Ile Phe Arg Asn Ala Met Lys Arg Lys 35 40 45 cgt gag ctg gca aat ctt aaa gag caa agt cat gga aat gtg gca aga 192 Arg Glu Leu Ala Asn Leu Lys Glu Gln Ser His Gly Asn Val Ala Arg 50 55 60 aat gct gct ttt cct aaa gag tat att aag cgc ccg aaa caa gtg cca 240 Asn Ala Ala Phe Pro Lys Glu Tyr Ile Lys Arg Pro Lys Gln Val Pro 65 70 75 80 agg aat gct act aac agg aaa aaa atc ctg att act tgg agc acc ggg 288 Arg Asn Ala Thr Asn Arg Lys Lys Ile Leu Ile Thr Trp Ser Thr Gly 85 90 95 aca gat cga gct aaa gag gca gct aat tca gtt gtt agt gag ata ttc 336 Thr Asp Arg Ala Lys Glu Ala Ala Asn Ser Val Val Ser Glu Ile Phe 100 105 110 aaa aaa aat cac aag gga aac atc aaa gtt gtg gat ccc act acc cac 384 Lys Lys Asn His Lys Gly Asn Ile Lys Val Val Asp Pro Thr Thr His 115 120 125 cga att gaa gca tcc aat att cgg tat ttt gcc aag ggc att gat ctc 432 Arg Ile Glu Ala Ser Asn Ile Arg Tyr Phe Ala Lys Gly Ile Asp Leu 130 135 140 gat aaa gtt gga ctc agt att gtt aat gta gag caa atc gat aat gaa 480 Asp Lys Val Gly Leu Ser Ile Val Asn Val Glu Gln Ile Asp Asn Glu 145 150 155 160 aat caa att cca ctt gtt aag ata gtc gaa agt cgt gta gcc tta aaa 528 Asn Gln Ile Pro Leu Val Lys Ile Val Glu Ser Arg Val Ala Leu Lys 165 170 175 aaa tat tca gac ttt ctg gct aaa aaa aag gaa aag gaa ctg atg gaa 576 Lys Tyr Ser Asp Phe Leu Ala Lys Lys Lys Glu Lys Glu Leu Met Glu 180 185 190 ttg gga gta ctg aat aag tct tac aag aat ttg gtg act gat aaa aaa 624 Leu Gly Val Leu Asn Lys Ser Tyr Lys Asn Leu Val Thr Asp Lys Lys 195 200 205 gaa gat aac ttg aag cat att aaa ata tca tgg cag att gaa agc gat 672 Glu Asp Asn Leu Lys His Ile Lys Ile Ser Trp Gln Ile Glu Ser Asp 210 215 220 gat tta aaa agg cag aag gct cac gaa ata gtt tcg cta ttg aaa aaa 720 Asp Leu Lys Arg Gln Lys Ala His Glu Ile Val Ser Leu Leu Lys Lys 225 230 235 240 ggg aat aaa gta acg tta tat ctt gat gac aag aat aac ata aat tca 768 Gly Asn Lys Val Thr Leu Tyr Leu Asp Asp Lys Asn Asn Ile Asn Ser 245 250 255 Page 183 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aac aat tgg ctt gaa aat ttt gag gag ctg gac cgc tct caa aaa ggt 816 Asn Asn Trp Leu Glu Asn Phe Glu Glu Leu Asp Arg Ser Gln Lys Gly 260 265 270 gaa cca ccc agg cta cca gaa tca gtt ttc cag aaa aga gct gct gtc 864 Glu Pro Pro Arg Leu Pro Glu Ser Val Phe Gln Lys Arg Ala Ala Val 275 280 285 ttg gag aca ttg aaa gag ata gtt agc gaa tat gct aat gat cct gtt 912 Leu Glu Thr Leu Lys Glu Ile Val Ser Glu Tyr Ala Asn Asp Pro Val 290 295 300 ctg cta ggt aac atg aac tcg aaa atg ata atg aaa ctt ata cca aag 960 Leu Leu Gly Asn Met Asn Ser Lys Met Ile Met Lys Leu Ile Pro Lys 305 310 315 320 gac gtt aaa cca caa aac aac gat aag agg gcg tta aag gaa ttg aga 1008 Asp Val Lys Pro Gln Asn Asn Asp Lys Arg Ala Leu Lys Glu Leu Arg 325 330 335 aag aag gag agg caa gaa aaa ttg caa aaa agg att cag aga aaa aaa 1056 Lys Lys Glu Arg Gln Glu Lys Leu Gln Lys Arg Ile Gln Arg Lys Lys 340 345 350 atg aat gaa atg taa 1071 Met Asn Glu Met 355 <210> 127 <211> 356 <212> PRT <213> Saccharomyces cerevisiae <400> 127 Met Leu Lys Val Pro Leu Ser Asp Val Leu Ser Gln Lys Met Leu Phe 1 5 10 15 Leu Lys Ser Phe Arg Tyr Phe His Cys Thr Lys Tyr Phe Ser Arg Asp 20 25 30 Asn Ala Ser Ser Thr Thr Asp Ile Phe Arg Asn Ala Met Lys Arg Lys 35 40 45 Arg Glu Leu Ala Asn Leu Lys Glu Gln Ser His Gly Asn Val Ala Arg 50 55 60 Asn Ala Ala Phe Pro Lys Glu Tyr Ile Lys Arg Pro Lys Gln Val Pro 65 70 75 80 Arg Asn Ala Thr Asn Arg Lys Lys Ile Leu Ile Thr Trp Ser Thr Gly 85 90 95 Thr Asp Arg Ala Lys Glu Ala Ala Asn Ser Val Val Ser Glu Ile Phe 100 105 110 Lys Lys Asn His Lys Gly Asn Ile Lys Val Val Asp Pro Thr Thr His 115 120 125 Page 184 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Ile Glu Ala Ser Asn Ile Arg Tyr Phe Ala Lys Gly Ile Asp Leu 130 135 140 Asp Lys Val Gly Leu Ser Ile Val Asn Val Glu Gln Ile Asp Asn Glu 145 150 155 160 Asn Gln Ile Pro Leu Val Lys Ile Val Glu Ser Arg Val Ala Leu Lys 165 170 175 Lys Tyr Ser Asp Phe Leu Ala Lys Lys Lys Glu Lys Glu Leu Met Glu 180 185 190 Leu Gly Val Leu Asn Lys Ser Tyr Lys Asn Leu Val Thr Asp Lys Lys 195 200 205 Glu Asp Asn Leu Lys His Ile Lys Ile Ser Trp Gln Ile Glu Ser Asp 210 215 220 Asp Leu Lys Arg Gln Lys Ala His Glu Ile Val Ser Leu Leu Lys Lys 225 230 235 240 Gly Asn Lys Val Thr Leu Tyr Leu Asp Asp Lys Asn Asn Ile Asn Ser 245 250 255 Asn Asn Trp Leu Glu Asn Phe Glu Glu Leu Asp Arg Ser Gln Lys Gly 260 265 270 Glu Pro Pro Arg Leu Pro Glu Ser Val Phe Gln Lys Arg Ala Ala Val 275 280 285 Leu Glu Thr Leu Lys Glu Ile Val Ser Glu Tyr Ala Asn Asp Pro Val 290 295 300 Leu Leu Gly Asn Met Asn Ser Lys Met Ile Met Lys Leu Ile Pro Lys 305 310 315 320 Asp Val Lys Pro Gln Asn Asn Asp Lys Arg Ala Leu Lys Glu Leu Arg 325 330 335 Lys Lys Glu Arg Gln Glu Lys Leu Gln Lys Arg Ile Gln Arg Lys Lys 340 345 350 Met Asn Glu Met 355 <210> 128 <211> 402 <212> DNA <213> Saccharomyces cerevisiae <220> Page 185 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <221> CDS <222> (1)..(402) <400> 128 atg gac aga gac cat att aat gac cat gac cat cga atg agc tat tcc 48 Met Asp Arg Asp His Ile Asn Asp His Asp His Arg Met Ser Tyr Ser 1 5 10 15 atc aac aag gac gac ttg ttg tta atg gtt ttg gcg gtt ttc att ccc 96 Ile Asn Lys Asp Asp Leu Leu Leu Met Val Leu Ala Val Phe Ile Pro 20 25 30 cca gtg gcc gtc tgg aag cgt aag ggt atg ttc aac agg gat aca cta 144 Pro Val Ala Val Trp Lys Arg Lys Gly Met Phe Asn Arg Asp Thr Leu 35 40 45 ttg aac tta ctt ctc ttc cta ctg tta ttc ttc cca gca atc att cac 192 Leu Asn Leu Leu Leu Phe Leu Leu Leu Phe Phe Pro Ala Ile Ile His 50 55 60 gct tgc tac gtt gta tat gaa acg agt agt gaa cgt tcg tac gat ctt 240 Ala Cys Tyr Val Val Tyr Glu Thr Ser Ser Glu Arg Ser Tyr Asp Leu 65 70 75 80 tca cgc aga cat gcg act gcg ccc gcc gta gac cgt gac ctg gaa gct 288 Ser Arg Arg His Ala Thr Ala Pro Ala Val Asp Arg Asp Leu Glu Ala 85 90 95 cac cct gca gag gaa tct caa gca cag cct cca gca tat gat gaa gac 336 His Pro Ala Glu Glu Ser Gln Ala Gln Pro Pro Ala Tyr Asp Glu Asp 100 105 110 gat gag gcc ggt gcc gat gtg ccc ttg atg gac aac aaa caa cag ctc 384 Asp Glu Ala Gly Ala Asp Val Pro Leu Met Asp Asn Lys Gln Gln Leu 115 120 125 tct tcc ggc cgt act tag 402 Ser Ser Gly Arg Thr 130 <210> 129 <211> 133 <212> PRT <213> Saccharomyces cerevisiae <400> 129 Met Asp Arg Asp His Ile Asn Asp His Asp His Arg Met Ser Tyr Ser 1 5 10 15 Ile Asn Lys Asp Asp Leu Leu Leu Met Val Leu Ala Val Phe Ile Pro 20 25 30 Pro Val Ala Val Trp Lys Arg Lys Gly Met Phe Asn Arg Asp Thr Leu 35 40 45 Leu Asn Leu Leu Leu Phe Leu Leu Leu Phe Phe Pro Ala Ile Ile His 50 55 60 Ala Cys Tyr Val Val Tyr Glu Thr Ser Ser Glu Arg Ser Tyr Asp Leu 65 70 75 80 Page 186 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Arg Arg His Ala Thr Ala Pro Ala Val Asp Arg Asp Leu Glu Ala 85 90 95 His Pro Ala Glu Glu Ser Gln Ala Gln Pro Pro Ala Tyr Asp Glu Asp 100 105 110 Asp Glu Ala Gly Ala Asp Val Pro Leu Met Asp Asn Lys Gln Gln Leu 115 120 125 Ser Ser Gly Arg Thr 130 <210> 130 <211> 768 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(768) <400> 130 atg gct gtc gga aag aat aag aga cta tcc aag ggt aag aaa ggt caa 48 Met Ala Val Gly Lys Asn Lys Arg Leu Ser Lys Gly Lys Lys Gly Gln 1 5 10 15 aag aag aga gtc gtt gac cca ttt acc aga aag gaa tgg ttc gac att 96 Lys Lys Arg Val Val Asp Pro Phe Thr Arg Lys Glu Trp Phe Asp Ile 20 25 30 aaa gct cca tcc act ttt gaa aac aga aat gtt ggt aag act tta gtt 144 Lys Ala Pro Ser Thr Phe Glu Asn Arg Asn Val Gly Lys Thr Leu Val 35 40 45 aac aag tcc act ggt ttg aag agt gct tca gat gct ttg aaa ggt aga 192 Asn Lys Ser Thr Gly Leu Lys Ser Ala Ser Asp Ala Leu Lys Gly Arg 50 55 60 gtt gtc gaa gtt tgc ttg gct gac tta cag ggt tct gaa gac cac tct 240 Val Val Glu Val Cys Leu Ala Asp Leu Gln Gly Ser Glu Asp His Ser 65 70 75 80 ttc aga aaa atc aaa tta aga gtt gac gaa gtc caa ggt aag aat tta 288 Phe Arg Lys Ile Lys Leu Arg Val Asp Glu Val Gln Gly Lys Asn Leu 85 90 95 ttg acc aac ttc cac ggt atg gac ttc act act gat aaa ttg aga tcc 336 Leu Thr Asn Phe His Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 atg gtt aga aag tgg caa act ttg atc gaa gct aac gtt act gtt aag 384 Met Val Arg Lys Trp Gln Thr Leu Ile Glu Ala Asn Val Thr Val Lys 115 120 125 act tct gat gat tac gtt ttg aga atc ttt gct atc gcc ttc acc aga 432 Thr Ser Asp Asp Tyr Val Leu Arg Ile Phe Ala Ile Ala Phe Thr Arg 130 135 140 aag caa gct aac caa gtt aag aga cac tct tac gct caa tct tcc cat 480 Lys Gln Ala Asn Gln Val Lys Arg His Ser Tyr Ala Gln Ser Ser His 145 150 155 160 atc aga gct atc aga aag gtt att tcc gaa atc ttg act aag gaa gtt 528 Page 187 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Arg Ala Ile Arg Lys Val Ile Ser Glu Ile Leu Thr Lys Glu Val 165 170 175 caa gga tct acc ttg gcc caa ttg acc tcc aag ttg att cca gaa gtt 576 Gln Gly Ser Thr Leu Ala Gln Leu Thr Ser Lys Leu Ile Pro Glu Val 180 185 190 atc aac aag gaa att gaa aac gcc acc aag gac att ttc cca cta caa 624 Ile Asn Lys Glu Ile Glu Asn Ala Thr Lys Asp Ile Phe Pro Leu Gln 195 200 205 aac atc cat gtt aga aag gtt aag ttg ttg aaa caa cca aag ttc gat 672 Asn Ile His Val Arg Lys Val Lys Leu Leu Lys Gln Pro Lys Phe Asp 210 215 220 gtc ggt gct ttg atg gct ttg cac ggt gaa ggt tct ggt gaa gaa aag 720 Val Gly Ala Leu Met Ala Leu His Gly Glu Gly Ser Gly Glu Glu Lys 225 230 235 240 ggt aag aag gtt acc ggt ttc aag gac gaa gtc ttg gaa act gtg taa 768 Gly Lys Lys Val Thr Gly Phe Lys Asp Glu Val Leu Glu Thr Val 245 250 255 <210> 131 <211> 255 <212> PRT <213> Saccharomyces cerevisiae <400> 131 Met Ala Val Gly Lys Asn Lys Arg Leu Ser Lys Gly Lys Lys Gly Gln 1 5 10 15 Lys Lys Arg Val Val Asp Pro Phe Thr Arg Lys Glu Trp Phe Asp Ile 20 25 30 Lys Ala Pro Ser Thr Phe Glu Asn Arg Asn Val Gly Lys Thr Leu Val 35 40 45 Asn Lys Ser Thr Gly Leu Lys Ser Ala Ser Asp Ala Leu Lys Gly Arg 50 55 60 Val Val Glu Val Cys Leu Ala Asp Leu Gln Gly Ser Glu Asp His Ser 65 70 75 80 Phe Arg Lys Ile Lys Leu Arg Val Asp Glu Val Gln Gly Lys Asn Leu 85 90 95 Leu Thr Asn Phe His Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Met Val Arg Lys Trp Gln Thr Leu Ile Glu Ala Asn Val Thr Val Lys 115 120 125 Thr Ser Asp Asp Tyr Val Leu Arg Ile Phe Ala Ile Ala Phe Thr Arg 130 135 140 Lys Gln Ala Asn Gln Val Lys Arg His Ser Tyr Ala Gln Ser Ser His Page 188 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 Ile Arg Ala Ile Arg Lys Val Ile Ser Glu Ile Leu Thr Lys Glu Val 165 170 175 Gln Gly Ser Thr Leu Ala Gln Leu Thr Ser Lys Leu Ile Pro Glu Val 180 185 190 Ile Asn Lys Glu Ile Glu Asn Ala Thr Lys Asp Ile Phe Pro Leu Gln 195 200 205 Asn Ile His Val Arg Lys Val Lys Leu Leu Lys Gln Pro Lys Phe Asp 210 215 220 Val Gly Ala Leu Met Ala Leu His Gly Glu Gly Ser Gly Glu Glu Lys 225 230 235 240 Gly Lys Lys Val Thr Gly Phe Lys Asp Glu Val Leu Glu Thr Val 245 250 255 <210> 132 <211> 339 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(339) <400> 132 atg tat ctc agt gcc cag ctt atg aga act gtc aca gcc tcc cac ttg 48 Met Tyr Leu Ser Ala Gln Leu Met Arg Thr Val Thr Ala Ser His Leu 1 5 10 15 acc ctc aga gcc ctc tcc act ccc ccc ctc ttt caa cat cgc cag ata 96 Thr Leu Arg Ala Leu Ser Thr Pro Pro Leu Phe Gln His Arg Gln Ile 20 25 30 gcc gcc gtt gaa tgg tgc ggg aca acc cgg cct ggc ctg gcc agg caa 144 Ala Ala Val Glu Trp Cys Gly Thr Thr Arg Pro Gly Leu Ala Arg Gln 35 40 45 aaa agg acg cag cac gcc tcg agc gtt att tcc aaa tcg ggc gta cta 192 Lys Arg Thr Gln His Ala Ser Ser Val Ile Ser Lys Ser Gly Val Leu 50 55 60 tca gcc aag ccc agc tcg gta ttt tta gcg ctt ctc gca gga aaa ttg 240 Ser Ala Lys Pro Ser Ser Val Phe Leu Ala Leu Leu Ala Gly Lys Leu 65 70 75 80 gct gag aag tat ata tac gcg aga atg ttg ctc ttc cat gtc tca gta 288 Ala Glu Lys Tyr Ile Tyr Ala Arg Met Leu Leu Phe His Val Ser Val 85 90 95 gtc aat gag tgt cca gtg gtg ttt cat tct gga cca gtt gtt tgg aag 336 Val Asn Glu Cys Pro Val Val Phe His Ser Gly Pro Val Val Trp Lys 100 105 110 tag 339 Page 189 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 133 <211> 112 <212> PRT <213> Saccharomyces cerevisiae <400> 133 Met Tyr Leu Ser Ala Gln Leu Met Arg Thr Val Thr Ala Ser His Leu 1 5 10 15 Thr Leu Arg Ala Leu Ser Thr Pro Pro Leu Phe Gln His Arg Gln Ile 20 25 30 Ala Ala Val Glu Trp Cys Gly Thr Thr Arg Pro Gly Leu Ala Arg Gln 35 40 45 Lys Arg Thr Gln His Ala Ser Ser Val Ile Ser Lys Ser Gly Val Leu 50 55 60 Ser Ala Lys Pro Ser Ser Val Phe Leu Ala Leu Leu Ala Gly Lys Leu 65 70 75 80 Ala Glu Lys Tyr Ile Tyr Ala Arg Met Leu Leu Phe His Val Ser Val 85 90 95 Val Asn Glu Cys Pro Val Val Phe His Ser Gly Pro Val Val Trp Lys 100 105 110 <210> 134 <211> 1422 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1422) <400> 134 atg ggt gga gaa att att act ttg caa gca ggt caa tgc ggg aac cac 48 Met Gly Gly Glu Ile Ile Thr Leu Gln Ala Gly Gln Cys Gly Asn His 1 5 10 15 gtt ggt aag ttt ctc tgg tct caa ttg gcg aaa gaa cac gct ata ggc 96 Val Gly Lys Phe Leu Trp Ser Gln Leu Ala Lys Glu His Ala Ile Gly 20 25 30 acc gat ggg cta tct cag ctt cct gat tcc agt acg gaa aga gat gat 144 Thr Asp Gly Leu Ser Gln Leu Pro Asp Ser Ser Thr Glu Arg Asp Asp 35 40 45 gac aca aag cct ttc ttc cgc gaa aac agt agg aat aag ttt acg cca 192 Asp Thr Lys Pro Phe Phe Arg Glu Asn Ser Arg Asn Lys Phe Thr Pro 50 55 60 agg gct att atg atg gat tcc gag cct agt gtc atc gcc gac gtg gag 240 Arg Ala Ile Met Met Asp Ser Glu Pro Ser Val Ile Ala Asp Val Glu 65 70 75 80 aac aca ttt cgt ggg ttt ttc gac cca aga aat acc tgg gta gct tct 288 Page 190 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Thr Phe Arg Gly Phe Phe Asp Pro Arg Asn Thr Trp Val Ala Ser 85 90 95 gat ggc gct agc gct ggt aat tct tgg gcc aat ggg tat gat ata gga 336 Asp Gly Ala Ser Ala Gly Asn Ser Trp Ala Asn Gly Tyr Asp Ile Gly 100 105 110 act cgt aac cag gat gat att ctt aac aag atc gac aag gag att gat 384 Thr Arg Asn Gln Asp Asp Ile Leu Asn Lys Ile Asp Lys Glu Ile Asp 115 120 125 tct acc gac aat ttc gaa ggt ttc cag ttg ctg cac tca gta gcc gga 432 Ser Thr Asp Asn Phe Glu Gly Phe Gln Leu Leu His Ser Val Ala Gly 130 135 140 ggg acc ggt tca ggg ctc gga tcc aac ctc tta gaa gcg ctg tgt gat 480 Gly Thr Gly Ser Gly Leu Gly Ser Asn Leu Leu Glu Ala Leu Cys Asp 145 150 155 160 cga tat cct aaa aaa ata ctc acg aca tat tct gtg ttc cct gca aga 528 Arg Tyr Pro Lys Lys Ile Leu Thr Thr Tyr Ser Val Phe Pro Ala Arg 165 170 175 tct tct gag gtt gtt gtt caa tct tat aac act att ctg gct ttg aga 576 Ser Ser Glu Val Val Val Gln Ser Tyr Asn Thr Ile Leu Ala Leu Arg 180 185 190 aga ctg ata gaa gat agc gat gca acg gtg gtg ttt gat aac gct tcg 624 Arg Leu Ile Glu Asp Ser Asp Ala Thr Val Val Phe Asp Asn Ala Ser 195 200 205 ttg ctg aat att tcc ggt aaa gtg ttt aga aat ccg aac atc gat tta 672 Leu Leu Asn Ile Ser Gly Lys Val Phe Arg Asn Pro Asn Ile Asp Leu 210 215 220 caa cac acg aat caa ttg ata tcg acc ata ata tct tca gta acg aac 720 Gln His Thr Asn Gln Leu Ile Ser Thr Ile Ile Ser Ser Val Thr Asn 225 230 235 240 agt ata cgg ttt ccg agt tac atg tat tca tcc atg tcc agt att tac 768 Ser Ile Arg Phe Pro Ser Tyr Met Tyr Ser Ser Met Ser Ser Ile Tyr 245 250 255 tct acc ttg att cct tct cct gaa ctt cat ttc cta agc cct agt ttc 816 Ser Thr Leu Ile Pro Ser Pro Glu Leu His Phe Leu Ser Pro Ser Phe 260 265 270 act cca ttt aca tca gat tat att cac gat gat ata gcg cat aaa ggc 864 Thr Pro Phe Thr Ser Asp Tyr Ile His Asp Asp Ile Ala His Lys Gly 275 280 285 cat tcc agt tat gac gtc atg tta gat tta tta gac cct tcc aat tct 912 His Ser Ser Tyr Asp Val Met Leu Asp Leu Leu Asp Pro Ser Asn Ser 290 295 300 ctt gtc tct acc gcg atg aac aat cca aca tat ttt aac gtt tat aat 960 Leu Val Ser Thr Ala Met Asn Asn Pro Thr Tyr Phe Asn Val Tyr Asn 305 310 315 320 aca atc att ggt aat gta gaa cct cgt cag ata tcg cgt gct atg acc 1008 Thr Ile Ile Gly Asn Val Glu Pro Arg Gln Ile Ser Arg Ala Met Thr 325 330 335 aaa tta caa caa cgc atc aaa ttc ccc tca tgg tcc tct tct gcg atg 1056 Lys Leu Gln Gln Arg Ile Lys Phe Pro Ser Trp Ser Ser Ser Ala Met 340 345 350 cac gtt aac att gga aga aga tcg cca tac ttg cct tta caa cca aat 1104 Page 191 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt His Val Asn Ile Gly Arg Arg Ser Pro Tyr Leu Pro Leu Gln Pro Asn 355 360 365 gaa aac gaa gtt agc ggc atg atg tta agc aat atg tct acc gtg gtg 1152 Glu Asn Glu Val Ser Gly Met Met Leu Ser Asn Met Ser Thr Val Val 370 375 380 aac gtc ttt gag aat gcg tgc aat act ttt gac aaa gta ttt gcc aag 1200 Asn Val Phe Glu Asn Ala Cys Asn Thr Phe Asp Lys Val Phe Ala Lys 385 390 395 400 ggc gca ttt tta aat aat tat aat gta ggc gac ttg ttc caa tca atg 1248 Gly Ala Phe Leu Asn Asn Tyr Asn Val Gly Asp Leu Phe Gln Ser Met 405 410 415 cag aac gtt caa gat gaa ttc gcc gag tca aga gaa gta gta caa agc 1296 Gln Asn Val Gln Asp Glu Phe Ala Glu Ser Arg Glu Val Val Gln Ser 420 425 430 ctg atg gag gat tat gta gct gca gaa caa gat tcg tac ttg gac gat 1344 Leu Met Glu Asp Tyr Val Ala Ala Glu Gln Asp Ser Tyr Leu Asp Asp 435 440 445 gta ctt gtt gat gat gaa aat atg gtt ggc gag ttg gaa gag gac ctg 1392 Val Leu Val Asp Asp Glu Asn Met Val Gly Glu Leu Glu Glu Asp Leu 450 455 460 gat gcc gac ggt gat cat aaa tta gta taa 1422 Asp Ala Asp Gly Asp His Lys Leu Val 465 470 <210> 135 <211> 473 <212> PRT <213> Saccharomyces cerevisiae <400> 135 Met Gly Gly Glu Ile Ile Thr Leu Gln Ala Gly Gln Cys Gly Asn His 1 5 10 15 Val Gly Lys Phe Leu Trp Ser Gln Leu Ala Lys Glu His Ala Ile Gly 20 25 30 Thr Asp Gly Leu Ser Gln Leu Pro Asp Ser Ser Thr Glu Arg Asp Asp 35 40 45 Asp Thr Lys Pro Phe Phe Arg Glu Asn Ser Arg Asn Lys Phe Thr Pro 50 55 60 Arg Ala Ile Met Met Asp Ser Glu Pro Ser Val Ile Ala Asp Val Glu 65 70 75 80 Asn Thr Phe Arg Gly Phe Phe Asp Pro Arg Asn Thr Trp Val Ala Ser 85 90 95 Asp Gly Ala Ser Ala Gly Asn Ser Trp Ala Asn Gly Tyr Asp Ile Gly 100 105 110 Thr Arg Asn Gln Asp Asp Ile Leu Asn Lys Ile Asp Lys Glu Ile Asp Page 192 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 115 120 125 Ser Thr Asp Asn Phe Glu Gly Phe Gln Leu Leu His Ser Val Ala Gly 130 135 140 Gly Thr Gly Ser Gly Leu Gly Ser Asn Leu Leu Glu Ala Leu Cys Asp 145 150 155 160 Arg Tyr Pro Lys Lys Ile Leu Thr Thr Tyr Ser Val Phe Pro Ala Arg 165 170 175 Ser Ser Glu Val Val Val Gln Ser Tyr Asn Thr Ile Leu Ala Leu Arg 180 185 190 Arg Leu Ile Glu Asp Ser Asp Ala Thr Val Val Phe Asp Asn Ala Ser 195 200 205 Leu Leu Asn Ile Ser Gly Lys Val Phe Arg Asn Pro Asn Ile Asp Leu 210 215 220 Gln His Thr Asn Gln Leu Ile Ser Thr Ile Ile Ser Ser Val Thr Asn 225 230 235 240 Ser Ile Arg Phe Pro Ser Tyr Met Tyr Ser Ser Met Ser Ser Ile Tyr 245 250 255 Ser Thr Leu Ile Pro Ser Pro Glu Leu His Phe Leu Ser Pro Ser Phe 260 265 270 Thr Pro Phe Thr Ser Asp Tyr Ile His Asp Asp Ile Ala His Lys Gly 275 280 285 His Ser Ser Tyr Asp Val Met Leu Asp Leu Leu Asp Pro Ser Asn Ser 290 295 300 Leu Val Ser Thr Ala Met Asn Asn Pro Thr Tyr Phe Asn Val Tyr Asn 305 310 315 320 Thr Ile Ile Gly Asn Val Glu Pro Arg Gln Ile Ser Arg Ala Met Thr 325 330 335 Lys Leu Gln Gln Arg Ile Lys Phe Pro Ser Trp Ser Ser Ser Ala Met 340 345 350 His Val Asn Ile Gly Arg Arg Ser Pro Tyr Leu Pro Leu Gln Pro Asn 355 360 365 Glu Asn Glu Val Ser Gly Met Met Leu Ser Asn Met Ser Thr Val Val 370 375 380 Asn Val Phe Glu Asn Ala Cys Asn Thr Phe Asp Lys Val Phe Ala Lys Page 193 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 385 390 395 400 Gly Ala Phe Leu Asn Asn Tyr Asn Val Gly Asp Leu Phe Gln Ser Met 405 410 415 Gln Asn Val Gln Asp Glu Phe Ala Glu Ser Arg Glu Val Val Gln Ser 420 425 430 Leu Met Glu Asp Tyr Val Ala Ala Glu Gln Asp Ser Tyr Leu Asp Asp 435 440 445 Val Leu Val Asp Asp Glu Asn Met Val Gly Glu Leu Glu Glu Asp Leu 450 455 460 Asp Ala Asp Gly Asp His Lys Leu Val 465 470 <210> 136 <211> 615 <212> DNA <213> Saccharomyces cerevisiae <400> 136 atgggtgcct acaaatattt ggaagaattg caaagaaaga agcaatctga tgttttgaga 60 ttcttgcaaa gagtcagagt ctgggaatac agacaaaaga atgtcattca cagagccgct 120 agaccaacta gaccagacaa ggctagaaga ttgggttaca aagctaagca aggtttcgtt 180 atctaccgtg tcagagttag acgtggtaac agaaagagac ctgttccaaa gggtgctact 240 tacggtaagc caactaacca aggtgtcaat gaattgaaat accaaagatc cttgagagct 300 accgctgaag aaagagttgg tcgtcgtgcc gctaacttga gagtcttgaa ctcctactgg 360 gttaaccaag attctactta caagtacttc gaagttatct tggtcgaccc tcaacacaag 420 gctatcagaa gagatgctcg ttacaactgg atctgtgacc cagttcacaa gcaccgtgaa 480 gctagaggtt tgactgccac tggtaagaaa tccagaggta tcaacaaggg tcacaaattc 540 aacaacacca aggctggtag aagaaagacc tggaagagac aaaacacttt gtccttgtgg 600 agatacagaa aataa 615 <210> 137 <211> 801 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(801) <400> 137 atg ttg aac gtg cta ttg aga agg aag gcc ttt tgt ttg gtg acg aag 48 Met Leu Asn Val Leu Leu Arg Arg Lys Ala Phe Cys Leu Val Thr Lys 1 5 10 15 aag ggt atg gct act gcc aca aca gct gca gct acg cat acc ccc aga 96 Page 194 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Gly Met Ala Thr Ala Thr Thr Ala Ala Ala Thr His Thr Pro Arg 20 25 30 ttg aaa act ttt aaa gtt tac aga tgg aat cca gac gag cca agt gct 144 Leu Lys Thr Phe Lys Val Tyr Arg Trp Asn Pro Asp Glu Pro Ser Ala 35 40 45 aaa cct cat tta cag tca tat caa gtg gat ctg aat gac tgt ggg ccc 192 Lys Pro His Leu Gln Ser Tyr Gln Val Asp Leu Asn Asp Cys Gly Pro 50 55 60 atg gta ctt gat gcg ctg tta aag atc aaa gac gaa cag gat tct acc 240 Met Val Leu Asp Ala Leu Leu Lys Ile Lys Asp Glu Gln Asp Ser Thr 65 70 75 80 cta act ttt aga aga tca tgt aga gaa ggt atc tgc ggt tca tgt gcc 288 Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser Cys Ala 85 90 95 atg aac att ggc ggt aga aac acg cta gct tgt ata tgt aag atc gac 336 Met Asn Ile Gly Gly Arg Asn Thr Leu Ala Cys Ile Cys Lys Ile Asp 100 105 110 cag aac gaa tcc aaa caa ctc aag atc tat cca tta ccc cac atg ttt 384 Gln Asn Glu Ser Lys Gln Leu Lys Ile Tyr Pro Leu Pro His Met Phe 115 120 125 att gtc aaa gat ttg gta cct gat tta act aac ttc tac caa caa tac 432 Ile Val Lys Asp Leu Val Pro Asp Leu Thr Asn Phe Tyr Gln Gln Tyr 130 135 140 aaa tct atc caa cct tac tta cag aga tca tcg ttt cca aag gat gga 480 Lys Ser Ile Gln Pro Tyr Leu Gln Arg Ser Ser Phe Pro Lys Asp Gly 145 150 155 160 acg gaa gtg cta caa agt att gaa gat cgt aag aaa ctg gat ggt ctt 528 Thr Glu Val Leu Gln Ser Ile Glu Asp Arg Lys Lys Leu Asp Gly Leu 165 170 175 tac gaa tgt att ctg tgt gca tgc tgc tct act tca tgt cca tcg tac 576 Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Tyr 180 185 190 tgg tgg aac caa gaa cag tat ttg ggc cct gcc gtg cta atg caa gcc 624 Trp Trp Asn Gln Glu Gln Tyr Leu Gly Pro Ala Val Leu Met Gln Ala 195 200 205 tac cgt tgg cta att gac tct aga gac caa gct aca aag aca aga aag 672 Tyr Arg Trp Leu Ile Asp Ser Arg Asp Gln Ala Thr Lys Thr Arg Lys 210 215 220 gcc atg cta aac aac tcc atg tca ttg tac aga tgt cac acc atc atg 720 Ala Met Leu Asn Asn Ser Met Ser Leu Tyr Arg Cys His Thr Ile Met 225 230 235 240 aac tgt act aga act tgt cca aag ggc ttg aat cct ggt ttg gct att 768 Asn Cys Thr Arg Thr Cys Pro Lys Gly Leu Asn Pro Gly Leu Ala Ile 245 250 255 gct gaa att aag aaa tct ttg gca ttt gcc tag 801 Ala Glu Ile Lys Lys Ser Leu Ala Phe Ala 260 265 <210> 138 <211> 266 <212> PRT <213> Saccharomyces cerevisiae Page 195 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 138 Met Leu Asn Val Leu Leu Arg Arg Lys Ala Phe Cys Leu Val Thr Lys 1 5 10 15 Lys Gly Met Ala Thr Ala Thr Thr Ala Ala Ala Thr His Thr Pro Arg 20 25 30 Leu Lys Thr Phe Lys Val Tyr Arg Trp Asn Pro Asp Glu Pro Ser Ala 35 40 45 Lys Pro His Leu Gln Ser Tyr Gln Val Asp Leu Asn Asp Cys Gly Pro 50 55 60 Met Val Leu Asp Ala Leu Leu Lys Ile Lys Asp Glu Gln Asp Ser Thr 65 70 75 80 Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser Cys Ala 85 90 95 Met Asn Ile Gly Gly Arg Asn Thr Leu Ala Cys Ile Cys Lys Ile Asp 100 105 110 Gln Asn Glu Ser Lys Gln Leu Lys Ile Tyr Pro Leu Pro His Met Phe 115 120 125 Ile Val Lys Asp Leu Val Pro Asp Leu Thr Asn Phe Tyr Gln Gln Tyr 130 135 140 Lys Ser Ile Gln Pro Tyr Leu Gln Arg Ser Ser Phe Pro Lys Asp Gly 145 150 155 160 Thr Glu Val Leu Gln Ser Ile Glu Asp Arg Lys Lys Leu Asp Gly Leu 165 170 175 Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Tyr 180 185 190 Trp Trp Asn Gln Glu Gln Tyr Leu Gly Pro Ala Val Leu Met Gln Ala 195 200 205 Tyr Arg Trp Leu Ile Asp Ser Arg Asp Gln Ala Thr Lys Thr Arg Lys 210 215 220 Ala Met Leu Asn Asn Ser Met Ser Leu Tyr Arg Cys His Thr Ile Met 225 230 235 240 Asn Cys Thr Arg Thr Cys Pro Lys Gly Leu Asn Pro Gly Leu Ala Ile 245 250 255 Ala Glu Ile Lys Lys Ser Leu Ala Phe Ala Page 196 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 260 265 <210> 139 <211> 1134 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1134) <400> 139 atg tct aaa ggg agg gtc aat cag aag cgt tac aag tat cct ctt cca 48 Met Ser Lys Gly Arg Val Asn Gln Lys Arg Tyr Lys Tyr Pro Leu Pro 1 5 10 15 att cac ccc gta gat gac ctt cca gag tta atc ctt cat aat ccg tta 96 Ile His Pro Val Asp Asp Leu Pro Glu Leu Ile Leu His Asn Pro Leu 20 25 30 tct tgg cta tat tgg gca tac cgc tat tac aag agt acg aac gca ctg 144 Ser Trp Leu Tyr Trp Ala Tyr Arg Tyr Tyr Lys Ser Thr Asn Ala Leu 35 40 45 aac gat aaa gta cat gta gat ttt ata gga gat acc act ctt cac atc 192 Asn Asp Lys Val His Val Asp Phe Ile Gly Asp Thr Thr Leu His Ile 50 55 60 acg gtt caa gat gac aag caa atg cta tat ctt tgg aat aat gga ttt 240 Thr Val Gln Asp Asp Lys Gln Met Leu Tyr Leu Trp Asn Asn Gly Phe 65 70 75 80 ttt ggc act ggt caa ttt agc agg agt gag cct aca tgg aaa gct aga 288 Phe Gly Thr Gly Gln Phe Ser Arg Ser Glu Pro Thr Trp Lys Ala Arg 85 90 95 aca gag gcc aga ctg ggt ctc aat gat act ccc ctc cac aat cgg gga 336 Thr Glu Ala Arg Leu Gly Leu Asn Asp Thr Pro Leu His Asn Arg Gly 100 105 110 gga aca aag agt aat act gaa acg gag atg act tta gag aag gtc aca 384 Gly Thr Lys Ser Asn Thr Glu Thr Glu Met Thr Leu Glu Lys Val Thr 115 120 125 caa cag agg aga tta caa aga tta gag ttc aag aaa gaa cgt gcg aag 432 Gln Gln Arg Arg Leu Gln Arg Leu Glu Phe Lys Lys Glu Arg Ala Lys 130 135 140 tta gaa aga gaa tta cta gaa tta aga aaa aaa ggt ggt cat atc gat 480 Leu Glu Arg Glu Leu Leu Glu Leu Arg Lys Lys Gly Gly His Ile Asp 145 150 155 160 gag gaa aac atc ctc ctt gag aaa caa cga gaa tca tta aga aaa ttt 528 Glu Glu Asn Ile Leu Leu Glu Lys Gln Arg Glu Ser Leu Arg Lys Phe 165 170 175 aaa cta aaa caa aca gaa gac gtg ggc atc gtt gca caa cag caa gac 576 Lys Leu Lys Gln Thr Glu Asp Val Gly Ile Val Ala Gln Gln Gln Asp 180 185 190 att tcc gaa tca aat tta aga gat gaa gac aac aat ctt ctt gat gag 624 Ile Ser Glu Ser Asn Leu Arg Asp Glu Asp Asn Asn Leu Leu Asp Glu 195 200 205 aac ggt gat ctt ttg cca cta gag tca cta gaa cta atg cca gtg gaa 672 Asn Gly Asp Leu Leu Pro Leu Glu Ser Leu Glu Leu Met Pro Val Glu Page 197 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 210 215 220 gct atg ttt tta act ttt gca ctt cct gtt ctt gac ata tct ccc gcg 720 Ala Met Phe Leu Thr Phe Ala Leu Pro Val Leu Asp Ile Ser Pro Ala 225 230 235 240 tgc ctg gca ggg aaa ctg ttt caa ttc gat gcc aaa tat aaa gat att 768 Cys Leu Ala Gly Lys Leu Phe Gln Phe Asp Ala Lys Tyr Lys Asp Ile 245 250 255 cac tcc ttt gtc aga tca tac gtt ata tac cat cac tac aga tca cac 816 His Ser Phe Val Arg Ser Tyr Val Ile Tyr His His Tyr Arg Ser His 260 265 270 ggt tgg tgc gta aga tct ggt ata aaa ttc ggc tgc gat tat tta tta 864 Gly Trp Cys Val Arg Ser Gly Ile Lys Phe Gly Cys Asp Tyr Leu Leu 275 280 285 tat aag aga ggg cca cca ttt caa cac gct gaa ttt tgt gtt atg ggt 912 Tyr Lys Arg Gly Pro Pro Phe Gln His Ala Glu Phe Cys Val Met Gly 290 295 300 ctt gac cac gac gtc tct aaa gat tat acg tgg tat tct agc ata gcc 960 Leu Asp His Asp Val Ser Lys Asp Tyr Thr Trp Tyr Ser Ser Ile Ala 305 310 315 320 cgt gtt gtg ggc ggc gca aag aag acg ttt gtg tta tgc tac gtg gag 1008 Arg Val Val Gly Gly Ala Lys Lys Thr Phe Val Leu Cys Tyr Val Glu 325 330 335 aga cta atc tcg gaa cag gag gcg ata gca cta tgg aaa tca aac aac 1056 Arg Leu Ile Ser Glu Gln Glu Ala Ile Ala Leu Trp Lys Ser Asn Asn 340 345 350 ttt act aaa ttg ttc aat agt ttt caa gtt ggt gaa gta ttg tat aag 1104 Phe Thr Lys Leu Phe Asn Ser Phe Gln Val Gly Glu Val Leu Tyr Lys 355 360 365 aga tgg gtt ccc gga aga aat aga gac tag 1134 Arg Trp Val Pro Gly Arg Asn Arg Asp 370 375 <210> 140 <211> 377 <212> PRT <213> Saccharomyces cerevisiae <400> 140 Met Ser Lys Gly Arg Val Asn Gln Lys Arg Tyr Lys Tyr Pro Leu Pro 1 5 10 15 Ile His Pro Val Asp Asp Leu Pro Glu Leu Ile Leu His Asn Pro Leu 20 25 30 Ser Trp Leu Tyr Trp Ala Tyr Arg Tyr Tyr Lys Ser Thr Asn Ala Leu 35 40 45 Asn Asp Lys Val His Val Asp Phe Ile Gly Asp Thr Thr Leu His Ile 50 55 60 Thr Val Gln Asp Asp Lys Gln Met Leu Tyr Leu Trp Asn Asn Gly Phe 65 70 75 80 Page 198 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Gly Thr Gly Gln Phe Ser Arg Ser Glu Pro Thr Trp Lys Ala Arg 85 90 95 Thr Glu Ala Arg Leu Gly Leu Asn Asp Thr Pro Leu His Asn Arg Gly 100 105 110 Gly Thr Lys Ser Asn Thr Glu Thr Glu Met Thr Leu Glu Lys Val Thr 115 120 125 Gln Gln Arg Arg Leu Gln Arg Leu Glu Phe Lys Lys Glu Arg Ala Lys 130 135 140 Leu Glu Arg Glu Leu Leu Glu Leu Arg Lys Lys Gly Gly His Ile Asp 145 150 155 160 Glu Glu Asn Ile Leu Leu Glu Lys Gln Arg Glu Ser Leu Arg Lys Phe 165 170 175 Lys Leu Lys Gln Thr Glu Asp Val Gly Ile Val Ala Gln Gln Gln Asp 180 185 190 Ile Ser Glu Ser Asn Leu Arg Asp Glu Asp Asn Asn Leu Leu Asp Glu 195 200 205 Asn Gly Asp Leu Leu Pro Leu Glu Ser Leu Glu Leu Met Pro Val Glu 210 215 220 Ala Met Phe Leu Thr Phe Ala Leu Pro Val Leu Asp Ile Ser Pro Ala 225 230 235 240 Cys Leu Ala Gly Lys Leu Phe Gln Phe Asp Ala Lys Tyr Lys Asp Ile 245 250 255 His Ser Phe Val Arg Ser Tyr Val Ile Tyr His His Tyr Arg Ser His 260 265 270 Gly Trp Cys Val Arg Ser Gly Ile Lys Phe Gly Cys Asp Tyr Leu Leu 275 280 285 Tyr Lys Arg Gly Pro Pro Phe Gln His Ala Glu Phe Cys Val Met Gly 290 295 300 Leu Asp His Asp Val Ser Lys Asp Tyr Thr Trp Tyr Ser Ser Ile Ala 305 310 315 320 Arg Val Val Gly Gly Ala Lys Lys Thr Phe Val Leu Cys Tyr Val Glu 325 330 335 Arg Leu Ile Ser Glu Gln Glu Ala Ile Ala Leu Trp Lys Ser Asn Asn 340 345 350 Page 199 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Thr Lys Leu Phe Asn Ser Phe Gln Val Gly Glu Val Leu Tyr Lys 355 360 365 Arg Trp Val Pro Gly Arg Asn Arg Asp 370 375 <210> 141 <211> 1182 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1182) <400> 141 atg tca tca aga ata att gtc ggc agt gca gca ttg gca gct gcc atc 48 Met Ser Ser Arg Ile Ile Val Gly Ser Ala Ala Leu Ala Ala Ala Ile 1 5 10 15 aca gct agc atc atg gtc aga gaa cag aag gcc aag ggt cag aga aga 96 Thr Ala Ser Ile Met Val Arg Glu Gln Lys Ala Lys Gly Gln Arg Arg 20 25 30 gag ggc aac gtc tcc gct tac tac aac ggc cag gag tac ggc agt tca 144 Glu Gly Asn Val Ser Ala Tyr Tyr Asn Gly Gln Glu Tyr Gly Ser Ser 35 40 45 gca ccc cca cag ttg gga aag cta cat aac ata aag caa ggc ata aag 192 Ala Pro Pro Gln Leu Gly Lys Leu His Asn Ile Lys Gln Gly Ile Lys 50 55 60 gaa gat gcc ttg tcg tta aaa gac gcg ctt ctg ggc gta tct caa aag 240 Glu Asp Ala Leu Ser Leu Lys Asp Ala Leu Leu Gly Val Ser Gln Lys 65 70 75 80 gct agg gaa gag gct cca aag gta act aag cgt gtg ata tca ccg gaa 288 Ala Arg Glu Glu Ala Pro Lys Val Thr Lys Arg Val Ile Ser Pro Glu 85 90 95 gag gat gct cag aca cgc aag cag cta ggc caa aaa gcc aag gat tct 336 Glu Asp Ala Gln Thr Arg Lys Gln Leu Gly Gln Lys Ala Lys Asp Ser 100 105 110 tcc tcg caa agc atc ttc aat tgg ggg ttt agt gag gct gaa aga agg 384 Ser Ser Gln Ser Ile Phe Asn Trp Gly Phe Ser Glu Ala Glu Arg Arg 115 120 125 aaa gcc ata gcc atc ggg gaa ttt gat act gct aag aag cgt ttc gaa 432 Lys Ala Ile Ala Ile Gly Glu Phe Asp Thr Ala Lys Lys Arg Phe Glu 130 135 140 gag gca gtg gat cgt aat gag aag gag ctc ttg tcc acg gtg atg aga 480 Glu Ala Val Asp Arg Asn Glu Lys Glu Leu Leu Ser Thr Val Met Arg 145 150 155 160 gag aag aag gcc gct ctg gac aga gca tcc att gag tac gaa agg tac 528 Glu Lys Lys Ala Ala Leu Asp Arg Ala Ser Ile Glu Tyr Glu Arg Tyr 165 170 175 ggg aga gcc aga gac ttt aat gag ctt tcg gac aag cta gac caa cag 576 Gly Arg Ala Arg Asp Phe Asn Glu Leu Ser Asp Lys Leu Asp Gln Gln 180 185 190 Page 200 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa agg aac agt aat cct ttg aaa cgc ctg ttg aag aat aac acg ggt 624 Glu Arg Asn Ser Asn Pro Leu Lys Arg Leu Leu Lys Asn Asn Thr Gly 195 200 205 gac gct aat act gaa gaa gcc gct gca aga agt gtc caa ggc tgg ggt 672 Asp Ala Asn Thr Glu Glu Ala Ala Ala Arg Ser Val Gln Gly Trp Gly 210 215 220 gat acg gca cag gag ttt ggt aga gaa gag ttg gag gaa gcc aag aga 720 Asp Thr Ala Gln Glu Phe Gly Arg Glu Glu Leu Glu Glu Ala Lys Arg 225 230 235 240 aat gct tct tca gag cca agc gag gcg caa aaa cgt ctt gac gag ctg 768 Asn Ala Ser Ser Glu Pro Ser Glu Ala Gln Lys Arg Leu Asp Glu Leu 245 250 255 aag aag atc aag gaa aag ggc tgg ttt ggt tac aac aaa ggg gag caa 816 Lys Lys Ile Lys Glu Lys Gly Trp Phe Gly Tyr Asn Lys Gly Glu Gln 260 265 270 agc gag caa cag att gct gaa cgg gta gcc aga ggt tta gaa gga tgg 864 Ser Glu Gln Gln Ile Ala Glu Arg Val Ala Arg Gly Leu Glu Gly Trp 275 280 285 ggt gaa aca gcc gct caa ctt tcc aag gac gaa atg gac gat tta aga 912 Gly Glu Thr Ala Ala Gln Leu Ser Lys Asp Glu Met Asp Asp Leu Arg 290 295 300 tgg aat tat gag aat tca aag aaa caa ctg gat aag aac gtg tcc gat 960 Trp Asn Tyr Glu Asn Ser Lys Lys Gln Leu Asp Lys Asn Val Ser Asp 305 310 315 320 gcc atg gac tcg tta tct aag gcg aag gag gac ttg aaa cag tac ggc 1008 Ala Met Asp Ser Leu Ser Lys Ala Lys Glu Asp Leu Lys Gln Tyr Gly 325 330 335 agc cac tgg tgg tct gga tgg act tcc aag gtc gac aat gac aag cag 1056 Ser His Trp Trp Ser Gly Trp Thr Ser Lys Val Asp Asn Asp Lys Gln 340 345 350 gct tta aaa gat gag gcc caa aag aag tac gat gaa gcg ttg aaa aag 1104 Ala Leu Lys Asp Glu Ala Gln Lys Lys Tyr Asp Glu Ala Leu Lys Lys 355 360 365 tac gat gaa gcc aag aac aaa ttc aaa gaa tgg aat gat aag ggt gat 1152 Tyr Asp Glu Ala Lys Asn Lys Phe Lys Glu Trp Asn Asp Lys Gly Asp 370 375 380 ggt aaa ttc tgg agc tcg aaa aag gac tag 1182 Gly Lys Phe Trp Ser Ser Lys Lys Asp 385 390 <210> 142 <211> 393 <212> PRT <213> Saccharomyces cerevisiae <400> 142 Met Ser Ser Arg Ile Ile Val Gly Ser Ala Ala Leu Ala Ala Ala Ile 1 5 10 15 Thr Ala Ser Ile Met Val Arg Glu Gln Lys Ala Lys Gly Gln Arg Arg 20 25 30 Page 201 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Gly Asn Val Ser Ala Tyr Tyr Asn Gly Gln Glu Tyr Gly Ser Ser 35 40 45 Ala Pro Pro Gln Leu Gly Lys Leu His Asn Ile Lys Gln Gly Ile Lys 50 55 60 Glu Asp Ala Leu Ser Leu Lys Asp Ala Leu Leu Gly Val Ser Gln Lys 65 70 75 80 Ala Arg Glu Glu Ala Pro Lys Val Thr Lys Arg Val Ile Ser Pro Glu 85 90 95 Glu Asp Ala Gln Thr Arg Lys Gln Leu Gly Gln Lys Ala Lys Asp Ser 100 105 110 Ser Ser Gln Ser Ile Phe Asn Trp Gly Phe Ser Glu Ala Glu Arg Arg 115 120 125 Lys Ala Ile Ala Ile Gly Glu Phe Asp Thr Ala Lys Lys Arg Phe Glu 130 135 140 Glu Ala Val Asp Arg Asn Glu Lys Glu Leu Leu Ser Thr Val Met Arg 145 150 155 160 Glu Lys Lys Ala Ala Leu Asp Arg Ala Ser Ile Glu Tyr Glu Arg Tyr 165 170 175 Gly Arg Ala Arg Asp Phe Asn Glu Leu Ser Asp Lys Leu Asp Gln Gln 180 185 190 Glu Arg Asn Ser Asn Pro Leu Lys Arg Leu Leu Lys Asn Asn Thr Gly 195 200 205 Asp Ala Asn Thr Glu Glu Ala Ala Ala Arg Ser Val Gln Gly Trp Gly 210 215 220 Asp Thr Ala Gln Glu Phe Gly Arg Glu Glu Leu Glu Glu Ala Lys Arg 225 230 235 240 Asn Ala Ser Ser Glu Pro Ser Glu Ala Gln Lys Arg Leu Asp Glu Leu 245 250 255 Lys Lys Ile Lys Glu Lys Gly Trp Phe Gly Tyr Asn Lys Gly Glu Gln 260 265 270 Ser Glu Gln Gln Ile Ala Glu Arg Val Ala Arg Gly Leu Glu Gly Trp 275 280 285 Gly Glu Thr Ala Ala Gln Leu Ser Lys Asp Glu Met Asp Asp Leu Arg 290 295 300 Page 202 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Trp Asn Tyr Glu Asn Ser Lys Lys Gln Leu Asp Lys Asn Val Ser Asp 305 310 315 320 Ala Met Asp Ser Leu Ser Lys Ala Lys Glu Asp Leu Lys Gln Tyr Gly 325 330 335 Ser His Trp Trp Ser Gly Trp Thr Ser Lys Val Asp Asn Asp Lys Gln 340 345 350 Ala Leu Lys Asp Glu Ala Gln Lys Lys Tyr Asp Glu Ala Leu Lys Lys 355 360 365 Tyr Asp Glu Ala Lys Asn Lys Phe Lys Glu Trp Asn Asp Lys Gly Asp 370 375 380 Gly Lys Phe Trp Ser Ser Lys Lys Asp 385 390 <210> 143 <211> 1083 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1083) <400> 143 atg tcc tca caa gaa tat aca act ttt ata gat ata cca gtg aca aga 48 Met Ser Ser Gln Glu Tyr Thr Thr Phe Ile Asp Ile Pro Val Thr Arg 1 5 10 15 gcg cag gtt gaa cac tgt tct tac tcg ttt tgg tcc tca ctg tat ccc 96 Ala Gln Val Glu His Cys Ser Tyr Ser Phe Trp Ser Ser Leu Tyr Pro 20 25 30 aaa tat gtg cca aaa tcc ata gtg tta aaa tcc tta ccg aaa aaa ttt 144 Lys Tyr Val Pro Lys Ser Ile Val Leu Lys Ser Leu Pro Lys Lys Phe 35 40 45 att caa tat ttg gaa caa gac ggt atc aag cta ccc caa gag gaa aac 192 Ile Gln Tyr Leu Glu Gln Asp Gly Ile Lys Leu Pro Gln Glu Glu Asn 50 55 60 tcc agg tct gtg tac acc gag gaa ata ata aga aat gaa gat aat gac 240 Ser Arg Ser Val Tyr Thr Glu Glu Ile Ile Arg Asn Glu Asp Asn Asp 65 70 75 80 tat agt gat tgg gag gac gat gag gat acc gcc acc gaa ttt gtc caa 288 Tyr Ser Asp Trp Glu Asp Asp Glu Asp Thr Ala Thr Glu Phe Val Gln 85 90 95 gaa gtt gag cca ttg ata gat ttt cca gaa tta cac cag aaa tta aag 336 Glu Val Glu Pro Leu Ile Asp Phe Pro Glu Leu His Gln Lys Leu Lys 100 105 110 gat gct ttg aac gaa tta ggt gca gtg gct ccc aag tta aac tgg tct 384 Asp Ala Leu Asn Glu Leu Gly Ala Val Ala Pro Lys Leu Asn Trp Ser 115 120 125 Page 203 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gca cca aga gac gct acc tgg att ttg ccg aat aac act atg aag tgt 432 Ala Pro Arg Asp Ala Thr Trp Ile Leu Pro Asn Asn Thr Met Lys Cys 130 135 140 aac gag gta aat gag ctt tac cta ttg ttg aac gca tcc aat tac ata 480 Asn Glu Val Asn Glu Leu Tyr Leu Leu Leu Asn Ala Ser Asn Tyr Ile 145 150 155 160 atg cat gac ctt caa aga gca ttt aaa ggc tgc gtg gac ggg gat gat 528 Met His Asp Leu Gln Arg Ala Phe Lys Gly Cys Val Asp Gly Asp Asp 165 170 175 ata aaa gga ttg aaa ttt gac ttg gta ctt aga caa tgg tgt gat atg 576 Ile Lys Gly Leu Lys Phe Asp Leu Val Leu Arg Gln Trp Cys Asp Met 180 185 190 aat ccg gca ctc gaa ttt agg gtc ttc gtt aag aat gcg cat atc gtt 624 Asn Pro Ala Leu Glu Phe Arg Val Phe Val Lys Asn Ala His Ile Val 195 200 205 ggg gcc acc cag cgt gat tta aat tat tat gac tat tta gat gag ttg 672 Gly Ala Thr Gln Arg Asp Leu Asn Tyr Tyr Asp Tyr Leu Asp Glu Leu 210 215 220 tca gat acc ttc aag gac ctt att gat gaa ata gtt cat gat gtc gtc 720 Ser Asp Thr Phe Lys Asp Leu Ile Asp Glu Ile Val His Asp Val Val 225 230 235 240 ctg ccc aag ttt cct gat aaa agt ttc gtt ctt gac gtt tat att cca 768 Leu Pro Lys Phe Pro Asp Lys Ser Phe Val Leu Asp Val Tyr Ile Pro 245 250 255 aga cct ttc aat aaa atc ttc att gtt gat ata aat ccg ttt gcc agg 816 Arg Pro Phe Asn Lys Ile Phe Ile Val Asp Ile Asn Pro Phe Ala Arg 260 265 270 aag aca gat tct ttg cta ttt tca tgg aac gag att gct gcg ata gca 864 Lys Thr Asp Ser Leu Leu Phe Ser Trp Asn Glu Ile Ala Ala Ile Ala 275 280 285 cct ccg aag aat gat gtt gaa gat tat gaa tta agg tta gtg acg agg 912 Pro Pro Lys Asn Asp Val Glu Asp Tyr Glu Leu Arg Leu Val Thr Arg 290 295 300 cat aac acg ggg aga ttc gct tca aaa gag cac tcc gaa aat cat gtt 960 His Asn Thr Gly Arg Phe Ala Ser Lys Glu His Ser Glu Asn His Val 305 310 315 320 cca cag gat ctc gta gaa gct agt tta aat cct gaa gca atc cga gag 1008 Pro Gln Asp Leu Val Glu Ala Ser Leu Asn Pro Glu Ala Ile Arg Glu 325 330 335 ctc act caa aaa tgg aaa gaa cta ctc tct caa cag gca aag gaa gaa 1056 Leu Thr Gln Lys Trp Lys Glu Leu Leu Ser Gln Gln Ala Lys Glu Glu 340 345 350 agc agt gat agt gag aat gaa act tag 1083 Ser Ser Asp Ser Glu Asn Glu Thr 355 360 <210> 144 <211> 360 <212> PRT <213> Saccharomyces cerevisiae <400> 144 Page 204 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Ser Ser Gln Glu Tyr Thr Thr Phe Ile Asp Ile Pro Val Thr Arg 1 5 10 15 Ala Gln Val Glu His Cys Ser Tyr Ser Phe Trp Ser Ser Leu Tyr Pro 20 25 30 Lys Tyr Val Pro Lys Ser Ile Val Leu Lys Ser Leu Pro Lys Lys Phe 35 40 45 Ile Gln Tyr Leu Glu Gln Asp Gly Ile Lys Leu Pro Gln Glu Glu Asn 50 55 60 Ser Arg Ser Val Tyr Thr Glu Glu Ile Ile Arg Asn Glu Asp Asn Asp 65 70 75 80 Tyr Ser Asp Trp Glu Asp Asp Glu Asp Thr Ala Thr Glu Phe Val Gln 85 90 95 Glu Val Glu Pro Leu Ile Asp Phe Pro Glu Leu His Gln Lys Leu Lys 100 105 110 Asp Ala Leu Asn Glu Leu Gly Ala Val Ala Pro Lys Leu Asn Trp Ser 115 120 125 Ala Pro Arg Asp Ala Thr Trp Ile Leu Pro Asn Asn Thr Met Lys Cys 130 135 140 Asn Glu Val Asn Glu Leu Tyr Leu Leu Leu Asn Ala Ser Asn Tyr Ile 145 150 155 160 Met His Asp Leu Gln Arg Ala Phe Lys Gly Cys Val Asp Gly Asp Asp 165 170 175 Ile Lys Gly Leu Lys Phe Asp Leu Val Leu Arg Gln Trp Cys Asp Met 180 185 190 Asn Pro Ala Leu Glu Phe Arg Val Phe Val Lys Asn Ala His Ile Val 195 200 205 Gly Ala Thr Gln Arg Asp Leu Asn Tyr Tyr Asp Tyr Leu Asp Glu Leu 210 215 220 Ser Asp Thr Phe Lys Asp Leu Ile Asp Glu Ile Val His Asp Val Val 225 230 235 240 Leu Pro Lys Phe Pro Asp Lys Ser Phe Val Leu Asp Val Tyr Ile Pro 245 250 255 Arg Pro Phe Asn Lys Ile Phe Ile Val Asp Ile Asn Pro Phe Ala Arg 260 265 270 Page 205 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Thr Asp Ser Leu Leu Phe Ser Trp Asn Glu Ile Ala Ala Ile Ala 275 280 285 Pro Pro Lys Asn Asp Val Glu Asp Tyr Glu Leu Arg Leu Val Thr Arg 290 295 300 His Asn Thr Gly Arg Phe Ala Ser Lys Glu His Ser Glu Asn His Val 305 310 315 320 Pro Gln Asp Leu Val Glu Ala Ser Leu Asn Pro Glu Ala Ile Arg Glu 325 330 335 Leu Thr Gln Lys Trp Lys Glu Leu Leu Ser Gln Gln Ala Lys Glu Glu 340 345 350 Ser Ser Asp Ser Glu Asn Glu Thr 355 360 <210> 145 <211> 1281 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1281) <400> 145 atg tcg cac caa aac cag ctt att cca caa gct tat att tct aac ttt 48 Met Ser His Gln Asn Gln Leu Ile Pro Gln Ala Tyr Ile Ser Asn Phe 1 5 10 15 cat aac aga ttg aca aac gaa gat gat ggt atc ccc atc ttt aca atg 96 His Asn Arg Leu Thr Asn Glu Asp Asp Gly Ile Pro Ile Phe Thr Met 20 25 30 gct caa caa aca agg cag cat aaa agg gct aaa gtg gtc aac tat gcg 144 Ala Gln Gln Thr Arg Gln His Lys Arg Ala Lys Val Val Asn Tyr Ala 35 40 45 gaa tat gac aac gat ctc ttt gat gaa ttc aat atg aac ggt tct aat 192 Glu Tyr Asp Asn Asp Leu Phe Asp Glu Phe Asn Met Asn Gly Ser Asn 50 55 60 ttc aac aat gct gat aca cac tat aaa gat aat gca gtg tct cat gaa 240 Phe Asn Asn Ala Asp Thr His Tyr Lys Asp Asn Ala Val Ser His Glu 65 70 75 80 aat act ccg gca ctt aca aat ggt gtt acc atg gac ggt tcc gaa tac 288 Asn Thr Pro Ala Leu Thr Asn Gly Val Thr Met Asp Gly Ser Glu Tyr 85 90 95 aat gtc cta gag aac atg aat gga gct gat agt att atc tct aac aac 336 Asn Val Leu Glu Asn Met Asn Gly Ala Asp Ser Ile Ile Ser Asn Asn 100 105 110 aaa tac gat gcg ggt tca aac atg gtt gtg gaa tct tta tcc ggt ttg 384 Lys Tyr Asp Ala Gly Ser Asn Met Val Val Glu Ser Leu Ser Gly Leu 115 120 125 aat agc aat aac aac gcc agc aat ggt ccg agc aac aaa gcg cag gca 432 Page 206 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Ser Asn Asn Asn Ala Ser Asn Gly Pro Ser Asn Lys Ala Gln Ala 130 135 140 cag gat att gga aac gcc gtt cta ccg gat ctg caa gac caa cac cac 480 Gln Asp Ile Gly Asn Ala Val Leu Pro Asp Leu Gln Asp Gln His His 145 150 155 160 aac ccc ttc aac ata ttg aga tac cct aaa ata aga gat act ttc att 528 Asn Pro Phe Asn Ile Leu Arg Tyr Pro Lys Ile Arg Asp Thr Phe Ile 165 170 175 aac gga aaa gtg gtg tct cca tat aga ctc aac act gat caa gaa acg 576 Asn Gly Lys Val Val Ser Pro Tyr Arg Leu Asn Thr Asp Gln Glu Thr 180 185 190 aag gca aac gcc aat tct gga gag gca atc atg ata cca att act ttg 624 Lys Ala Asn Ala Asn Ser Gly Glu Ala Ile Met Ile Pro Ile Thr Leu 195 200 205 gat ata gaa cat atg ggt cat acc ata aaa gac cag ttt ctc tgg aac 672 Asp Ile Glu His Met Gly His Thr Ile Lys Asp Gln Phe Leu Trp Asn 210 215 220 tac aat gac gac tcc ata tct ccg gag gaa ttt gcc tct ata tac tgt 720 Tyr Asn Asp Asp Ser Ile Ser Pro Glu Glu Phe Ala Ser Ile Tyr Cys 225 230 235 240 aaa gat ctt gat atg act tcc gct acc tta caa act caa att gcg aat 768 Lys Asp Leu Asp Met Thr Ser Ala Thr Leu Gln Thr Gln Ile Ala Asn 245 250 255 ata ata aaa gag cag ttg aaa gac ctc gaa aat att gca gcc act gag 816 Ile Ile Lys Glu Gln Leu Lys Asp Leu Glu Asn Ile Ala Ala Thr Glu 260 265 270 ata atg tct gac ctc cac gtg ata atc aac cta acc tgc aac tta caa 864 Ile Met Ser Asp Leu His Val Ile Ile Asn Leu Thr Cys Asn Leu Gln 275 280 285 gac aga ttt ttt gaa gat aac ttc cag tgg aac ttg aac gac aaa tca 912 Asp Arg Phe Phe Glu Asp Asn Phe Gln Trp Asn Leu Asn Asp Lys Ser 290 295 300 ctt act cca gaa aga ttt gct aca tcc att gta cag gac ctt ggc tta 960 Leu Thr Pro Glu Arg Phe Ala Thr Ser Ile Val Gln Asp Leu Gly Leu 305 310 315 320 aca aga gag ttc atc ccc tta ata tct caa tcg ctt cat gaa act atc 1008 Thr Arg Glu Phe Ile Pro Leu Ile Ser Gln Ser Leu His Glu Thr Ile 325 330 335 ttg aag ata aag aag gac tgg gta gat ggc cac ttg att cag gac cat 1056 Leu Lys Ile Lys Lys Asp Trp Val Asp Gly His Leu Ile Gln Asp His 340 345 350 gtc cca aac gat gcc gca ttt ggg tac tta tct ggt ata agg ctg gat 1104 Val Pro Asn Asp Ala Ala Phe Gly Tyr Leu Ser Gly Ile Arg Leu Asp 355 360 365 att gat gaa ctg ggc tcc aat tgg tgc cca agg gtg gaa ata tta aca 1152 Ile Asp Glu Leu Gly Ser Asn Trp Cys Pro Arg Val Glu Ile Leu Thr 370 375 380 aaa gaa gaa ata caa aag aga gaa att gaa aaa gaa aga aac tta aga 1200 Lys Glu Glu Ile Gln Lys Arg Glu Ile Glu Lys Glu Arg Asn Leu Arg 385 390 395 400 aga ttg aaa aga gaa act gat aga tta tct aga agg ggc agg aga aga 1248 Page 207 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Leu Lys Arg Glu Thr Asp Arg Leu Ser Arg Arg Gly Arg Arg Arg 405 410 415 tta gat gac tta gaa acc aca atg aga atg tag 1281 Leu Asp Asp Leu Glu Thr Thr Met Arg Met 420 425 <210> 146 <211> 426 <212> PRT <213> Saccharomyces cerevisiae <400> 146 Met Ser His Gln Asn Gln Leu Ile Pro Gln Ala Tyr Ile Ser Asn Phe 1 5 10 15 His Asn Arg Leu Thr Asn Glu Asp Asp Gly Ile Pro Ile Phe Thr Met 20 25 30 Ala Gln Gln Thr Arg Gln His Lys Arg Ala Lys Val Val Asn Tyr Ala 35 40 45 Glu Tyr Asp Asn Asp Leu Phe Asp Glu Phe Asn Met Asn Gly Ser Asn 50 55 60 Phe Asn Asn Ala Asp Thr His Tyr Lys Asp Asn Ala Val Ser His Glu 65 70 75 80 Asn Thr Pro Ala Leu Thr Asn Gly Val Thr Met Asp Gly Ser Glu Tyr 85 90 95 Asn Val Leu Glu Asn Met Asn Gly Ala Asp Ser Ile Ile Ser Asn Asn 100 105 110 Lys Tyr Asp Ala Gly Ser Asn Met Val Val Glu Ser Leu Ser Gly Leu 115 120 125 Asn Ser Asn Asn Asn Ala Ser Asn Gly Pro Ser Asn Lys Ala Gln Ala 130 135 140 Gln Asp Ile Gly Asn Ala Val Leu Pro Asp Leu Gln Asp Gln His His 145 150 155 160 Asn Pro Phe Asn Ile Leu Arg Tyr Pro Lys Ile Arg Asp Thr Phe Ile 165 170 175 Asn Gly Lys Val Val Ser Pro Tyr Arg Leu Asn Thr Asp Gln Glu Thr 180 185 190 Lys Ala Asn Ala Asn Ser Gly Glu Ala Ile Met Ile Pro Ile Thr Leu 195 200 205 Asp Ile Glu His Met Gly His Thr Ile Lys Asp Gln Phe Leu Trp Asn Page 208 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 210 215 220 Tyr Asn Asp Asp Ser Ile Ser Pro Glu Glu Phe Ala Ser Ile Tyr Cys 225 230 235 240 Lys Asp Leu Asp Met Thr Ser Ala Thr Leu Gln Thr Gln Ile Ala Asn 245 250 255 Ile Ile Lys Glu Gln Leu Lys Asp Leu Glu Asn Ile Ala Ala Thr Glu 260 265 270 Ile Met Ser Asp Leu His Val Ile Ile Asn Leu Thr Cys Asn Leu Gln 275 280 285 Asp Arg Phe Phe Glu Asp Asn Phe Gln Trp Asn Leu Asn Asp Lys Ser 290 295 300 Leu Thr Pro Glu Arg Phe Ala Thr Ser Ile Val Gln Asp Leu Gly Leu 305 310 315 320 Thr Arg Glu Phe Ile Pro Leu Ile Ser Gln Ser Leu His Glu Thr Ile 325 330 335 Leu Lys Ile Lys Lys Asp Trp Val Asp Gly His Leu Ile Gln Asp His 340 345 350 Val Pro Asn Asp Ala Ala Phe Gly Tyr Leu Ser Gly Ile Arg Leu Asp 355 360 365 Ile Asp Glu Leu Gly Ser Asn Trp Cys Pro Arg Val Glu Ile Leu Thr 370 375 380 Lys Glu Glu Ile Gln Lys Arg Glu Ile Glu Lys Glu Arg Asn Leu Arg 385 390 395 400 Arg Leu Lys Arg Glu Thr Asp Arg Leu Ser Arg Arg Gly Arg Arg Arg 405 410 415 Leu Asp Asp Leu Glu Thr Thr Met Arg Met 420 425 <210> 147 <211> 462 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(462) <400> 147 atg ggt aag aaa aac act aaa ggt ggt aaa aaa ggt aga aga ggt aag 48 Met Gly Lys Lys Asn Thr Lys Gly Gly Lys Lys Gly Arg Arg Gly Lys Page 209 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 aac gac tct gac ggt cca aag cgt gaa ctt att tat aag gaa gaa ggc 96 Asn Asp Ser Asp Gly Pro Lys Arg Glu Leu Ile Tyr Lys Glu Glu Gly 20 25 30 caa gaa tat gct caa atc acc aag atg ttg ggt aat gga aga gtc gaa 144 Gln Glu Tyr Ala Gln Ile Thr Lys Met Leu Gly Asn Gly Arg Val Glu 35 40 45 gcc agt tgc ttt gat ggt aat aag aga atg gcc cat att aga ggt aag 192 Ala Ser Cys Phe Asp Gly Asn Lys Arg Met Ala His Ile Arg Gly Lys 50 55 60 tta aga aag aaa gtc tgg atg gga caa ggt gat att att ctt gtt tcc 240 Leu Arg Lys Lys Val Trp Met Gly Gln Gly Asp Ile Ile Leu Val Ser 65 70 75 80 tta aga gat ttc caa gat gac caa tgt gat gtt gtc cac aaa tat aat 288 Leu Arg Asp Phe Gln Asp Asp Gln Cys Asp Val Val His Lys Tyr Asn 85 90 95 tta gat gaa gcc aga aca ctg aaa aac caa ggt gaa ctt cct gaa aac 336 Leu Asp Glu Ala Arg Thr Leu Lys Asn Gln Gly Glu Leu Pro Glu Asn 100 105 110 gcc aaa att aat gaa aca gac aac ttt ggt ttc gaa tct gat gaa gac 384 Ala Lys Ile Asn Glu Thr Asp Asn Phe Gly Phe Glu Ser Asp Glu Asp 115 120 125 gtt aac ttt gaa ttt ggt aac gct gat gaa gat gat gag gaa ggt gaa 432 Val Asn Phe Glu Phe Gly Asn Ala Asp Glu Asp Asp Glu Glu Gly Glu 130 135 140 gat gaa gaa ctt gat att gat gac att taa 462 Asp Glu Glu Leu Asp Ile Asp Asp Ile 145 150 <210> 148 <211> 153 <212> PRT <213> Saccharomyces cerevisiae <400> 148 Met Gly Lys Lys Asn Thr Lys Gly Gly Lys Lys Gly Arg Arg Gly Lys 1 5 10 15 Asn Asp Ser Asp Gly Pro Lys Arg Glu Leu Ile Tyr Lys Glu Glu Gly 20 25 30 Gln Glu Tyr Ala Gln Ile Thr Lys Met Leu Gly Asn Gly Arg Val Glu 35 40 45 Ala Ser Cys Phe Asp Gly Asn Lys Arg Met Ala His Ile Arg Gly Lys 50 55 60 Leu Arg Lys Lys Val Trp Met Gly Gln Gly Asp Ile Ile Leu Val Ser 65 70 75 80 Leu Arg Asp Phe Gln Asp Asp Gln Cys Asp Val Val His Lys Tyr Asn 85 90 95 Page 210 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Asp Glu Ala Arg Thr Leu Lys Asn Gln Gly Glu Leu Pro Glu Asn 100 105 110 Ala Lys Ile Asn Glu Thr Asp Asn Phe Gly Phe Glu Ser Asp Glu Asp 115 120 125 Val Asn Phe Glu Phe Gly Asn Ala Asp Glu Asp Asp Glu Glu Gly Glu 130 135 140 Asp Glu Glu Leu Asp Ile Asp Asp Ile 145 150 <210> 149 <211> 486 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(486) <400> 149 atg ata aaa gtc gat act tcc gat gca ttg ttg aaa aat tcg tta aca 48 Met Ile Lys Val Asp Thr Ser Asp Ala Leu Leu Lys Asn Ser Leu Thr 1 5 10 15 tca ata aaa tgg aca tta aat atg ttg gat att tta ttc agt tgt gac 96 Ser Ile Lys Trp Thr Leu Asn Met Leu Asp Ile Leu Phe Ser Cys Asp 20 25 30 att ttt tca tta atc aag gat tcc ata cgt tct ttg ata aca gaa aca 144 Ile Phe Ser Leu Ile Lys Asp Ser Ile Arg Ser Leu Ile Thr Glu Thr 35 40 45 ttt tcc tcg gtg aat acc gtg agt aca tcg acg gta aag cct gta cga 192 Phe Ser Ser Val Asn Thr Val Ser Thr Ser Thr Val Lys Pro Val Arg 50 55 60 tta ttg tgt tgc tta gtt tgt tcc aat agc aag tcg tgc aca ata tct 240 Leu Leu Cys Cys Leu Val Cys Ser Asn Ser Lys Ser Cys Thr Ile Ser 65 70 75 80 aac ata acc aga gat cct gaa tca gaa tgt gat aag ggg agc aga atc 288 Asn Ile Thr Arg Asp Pro Glu Ser Glu Cys Asp Lys Gly Ser Arg Ile 85 90 95 tta gag acg gat cct tct ttt tca aat ggg tat ata act tta aat agg 336 Leu Glu Thr Asp Pro Ser Phe Ser Asn Gly Tyr Ile Thr Leu Asn Arg 100 105 110 ttc ctg aaa tat tca tcc ttc atc att tgt ttc ctt tgt tta gta cta 384 Phe Leu Lys Tyr Ser Ser Phe Ile Ile Cys Phe Leu Cys Leu Val Leu 115 120 125 aca aac ttg atg aaa cat tca tcg caa aac ttt tcc ttt cta gac tca 432 Thr Asn Leu Met Lys His Ser Ser Gln Asn Phe Ser Phe Leu Asp Ser 130 135 140 act gtc gct gga ttt ctg gca gat gca ggg cac ctc tgg cac tcc ata 480 Thr Val Ala Gly Phe Leu Ala Asp Ala Gly His Leu Trp His Ser Ile 145 150 155 160 Page 211 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt act tga 486 Thr <210> 150 <211> 161 <212> PRT <213> Saccharomyces cerevisiae <400> 150 Met Ile Lys Val Asp Thr Ser Asp Ala Leu Leu Lys Asn Ser Leu Thr 1 5 10 15 Ser Ile Lys Trp Thr Leu Asn Met Leu Asp Ile Leu Phe Ser Cys Asp 20 25 30 Ile Phe Ser Leu Ile Lys Asp Ser Ile Arg Ser Leu Ile Thr Glu Thr 35 40 45 Phe Ser Ser Val Asn Thr Val Ser Thr Ser Thr Val Lys Pro Val Arg 50 55 60 Leu Leu Cys Cys Leu Val Cys Ser Asn Ser Lys Ser Cys Thr Ile Ser 65 70 75 80 Asn Ile Thr Arg Asp Pro Glu Ser Glu Cys Asp Lys Gly Ser Arg Ile 85 90 95 Leu Glu Thr Asp Pro Ser Phe Ser Asn Gly Tyr Ile Thr Leu Asn Arg 100 105 110 Phe Leu Lys Tyr Ser Ser Phe Ile Ile Cys Phe Leu Cys Leu Val Leu 115 120 125 Thr Asn Leu Met Lys His Ser Ser Gln Asn Phe Ser Phe Leu Asp Ser 130 135 140 Thr Val Ala Gly Phe Leu Ala Asp Ala Gly His Leu Trp His Ser Ile 145 150 155 160 Thr <210> 151 <211> 690 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(690) <400> 151 Page 212 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atg act gtt tct act tcc aag acc cca aaa aag aat att aag tat acc 48 Met Thr Val Ser Thr Ser Lys Thr Pro Lys Lys Asn Ile Lys Tyr Thr 1 5 10 15 tta aca cat act tta caa aaa tgg aaa gaa act tta aag aaa att acc 96 Leu Thr His Thr Leu Gln Lys Trp Lys Glu Thr Leu Lys Lys Ile Thr 20 25 30 cac gaa acg ttg agt agt atc gat gac tct agt gga agc gat gaa aaa 144 His Glu Thr Leu Ser Ser Ile Asp Asp Ser Ser Gly Ser Asp Glu Lys 35 40 45 ata gag gct ctg ttt act gtg tct cag cct gcc gtc gta gcc tcc aag 192 Ile Glu Ala Leu Phe Thr Val Ser Gln Pro Ala Val Val Ala Ser Lys 50 55 60 ggt ata gac aga gat agt ggt gct tct atg tcg cag gta gga gga ggt 240 Gly Ile Asp Arg Asp Ser Gly Ala Ser Met Ser Gln Val Gly Gly Gly 65 70 75 80 gtc aat agt aca ttg gag atg aag ctc aca gat gag agt gag gaa tct 288 Val Asn Ser Thr Leu Glu Met Lys Leu Thr Asp Glu Ser Glu Glu Ser 85 90 95 agc tct gct aat aac acg acc aca acc gcc tcg cat act cta tcg aat 336 Ser Ser Ala Asn Asn Thr Thr Thr Thr Ala Ser His Thr Leu Ser Asn 100 105 110 tcg aag aag tct acg cag aac ttt gaa aac tat aac gta gtg gag gaa 384 Ser Lys Lys Ser Thr Gln Asn Phe Glu Asn Tyr Asn Val Val Glu Glu 115 120 125 cgc ata aaa tta gca cag aaa agt aag gcg ccg ttt tgt aac gct gag 432 Arg Ile Lys Leu Ala Gln Lys Ser Lys Ala Pro Phe Cys Asn Ala Glu 130 135 140 aaa atc tgg aaa cga aga aga caa ctc tgg aca caa ccc act gag caa 480 Lys Ile Trp Lys Arg Arg Arg Gln Leu Trp Thr Gln Pro Thr Glu Gln 145 150 155 160 agt gaa agc gcc aat aat gac gga gtt act cga agg gag att ttc caa 528 Ser Glu Ser Ala Asn Asn Asp Gly Val Thr Arg Arg Glu Ile Phe Gln 165 170 175 gct ata cct cag gaa tat tat gct cga gtt tac aag aaa ctg gtg gta 576 Ala Ile Pro Gln Glu Tyr Tyr Ala Arg Val Tyr Lys Lys Leu Val Val 180 185 190 gat gat aag cca ttg aga gag cct cta aat ctg gaa gat gct tta caa 624 Asp Asp Lys Pro Leu Arg Glu Pro Leu Asn Leu Glu Asp Ala Leu Gln 195 200 205 gtc ata aat gca ggc tgg acg gaa acg aga aag tgg gct aat gct gcc 672 Val Ile Asn Ala Gly Trp Thr Glu Thr Arg Lys Trp Ala Asn Ala Ala 210 215 220 aag gca tgc cat gac tga 690 Lys Ala Cys His Asp 225 <210> 152 <211> 229 <212> PRT <213> Saccharomyces cerevisiae <400> 152 Page 213 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Thr Val Ser Thr Ser Lys Thr Pro Lys Lys Asn Ile Lys Tyr Thr 1 5 10 15 Leu Thr His Thr Leu Gln Lys Trp Lys Glu Thr Leu Lys Lys Ile Thr 20 25 30 His Glu Thr Leu Ser Ser Ile Asp Asp Ser Ser Gly Ser Asp Glu Lys 35 40 45 Ile Glu Ala Leu Phe Thr Val Ser Gln Pro Ala Val Val Ala Ser Lys 50 55 60 Gly Ile Asp Arg Asp Ser Gly Ala Ser Met Ser Gln Val Gly Gly Gly 65 70 75 80 Val Asn Ser Thr Leu Glu Met Lys Leu Thr Asp Glu Ser Glu Glu Ser 85 90 95 Ser Ser Ala Asn Asn Thr Thr Thr Thr Ala Ser His Thr Leu Ser Asn 100 105 110 Ser Lys Lys Ser Thr Gln Asn Phe Glu Asn Tyr Asn Val Val Glu Glu 115 120 125 Arg Ile Lys Leu Ala Gln Lys Ser Lys Ala Pro Phe Cys Asn Ala Glu 130 135 140 Lys Ile Trp Lys Arg Arg Arg Gln Leu Trp Thr Gln Pro Thr Glu Gln 145 150 155 160 Ser Glu Ser Ala Asn Asn Asp Gly Val Thr Arg Arg Glu Ile Phe Gln 165 170 175 Ala Ile Pro Gln Glu Tyr Tyr Ala Arg Val Tyr Lys Lys Leu Val Val 180 185 190 Asp Asp Lys Pro Leu Arg Glu Pro Leu Asn Leu Glu Asp Ala Leu Gln 195 200 205 Val Ile Asn Ala Gly Trp Thr Glu Thr Arg Lys Trp Ala Asn Ala Ala 210 215 220 Lys Ala Cys His Asp 225 <210> 153 <211> 654 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS Page 214 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(654) <400> 153 atg agt tcc cta tta ata tca tac gaa tct gac ttc aaa aca acc tta 48 Met Ser Ser Leu Leu Ile Ser Tyr Glu Ser Asp Phe Lys Thr Thr Leu 1 5 10 15 gaa caa gcc aaa gcg agc tta gca gag gcc ccc tca caa ccg tta tca 96 Glu Gln Ala Lys Ala Ser Leu Ala Glu Ala Pro Ser Gln Pro Leu Ser 20 25 30 cag aga aat act aca ctg aag cac gta gaa cag caa caa gat gag ttg 144 Gln Arg Asn Thr Thr Leu Lys His Val Glu Gln Gln Gln Asp Glu Leu 35 40 45 ttt gac ctg cta gat cag atg gat gta gaa gtt aat aac agc ata ggc 192 Phe Asp Leu Leu Asp Gln Met Asp Val Glu Val Asn Asn Ser Ile Gly 50 55 60 gat gcc tca gaa cgt gct acg tac aag gcg aag tta aga gaa tgg aag 240 Asp Ala Ser Glu Arg Ala Thr Tyr Lys Ala Lys Leu Arg Glu Trp Lys 65 70 75 80 aag act ata cag agc gat atc aaa cga cca ctg caa tcc tta gta gac 288 Lys Thr Ile Gln Ser Asp Ile Lys Arg Pro Leu Gln Ser Leu Val Asp 85 90 95 tca ggc gat cgt gat aga ctt ttt gga gat ctt aac gca tct aat att 336 Ser Gly Asp Arg Asp Arg Leu Phe Gly Asp Leu Asn Ala Ser Asn Ile 100 105 110 gac gat gac caa agg caa cag ttg ttg agc aac cat gca atc tta cag 384 Asp Asp Asp Gln Arg Gln Gln Leu Leu Ser Asn His Ala Ile Leu Gln 115 120 125 aaa tcg gga gat aga cta aaa gat gcc agt aga ata gca aat gaa act 432 Lys Ser Gly Asp Arg Leu Lys Asp Ala Ser Arg Ile Ala Asn Glu Thr 130 135 140 gaa gga ata ggg tca caa ata atg atg gat tta agg tca cag aga gaa 480 Glu Gly Ile Gly Ser Gln Ile Met Met Asp Leu Arg Ser Gln Arg Glu 145 150 155 160 act ttg gaa aat gca aga cag acc ttg ttt caa gcg gat tca tat gtg 528 Thr Leu Glu Asn Ala Arg Gln Thr Leu Phe Gln Ala Asp Ser Tyr Val 165 170 175 gat aaa agt ata aag aca cta aaa aca atg act aga agg cta gtt gct 576 Asp Lys Ser Ile Lys Thr Leu Lys Thr Met Thr Arg Arg Leu Val Ala 180 185 190 aat aaa ttc ata agc tat gcc att atc gca gtc ctt ata tta ttg att 624 Asn Lys Phe Ile Ser Tyr Ala Ile Ile Ala Val Leu Ile Leu Leu Ile 195 200 205 ttg cta gtt ttg ttc tca aag ttt aaa taa 654 Leu Leu Val Leu Phe Ser Lys Phe Lys 210 215 <210> 154 <211> 217 <212> PRT <213> Saccharomyces cerevisiae <400> 154 Met Ser Ser Leu Leu Ile Ser Tyr Glu Ser Asp Phe Lys Thr Thr Leu Page 215 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 Glu Gln Ala Lys Ala Ser Leu Ala Glu Ala Pro Ser Gln Pro Leu Ser 20 25 30 Gln Arg Asn Thr Thr Leu Lys His Val Glu Gln Gln Gln Asp Glu Leu 35 40 45 Phe Asp Leu Leu Asp Gln Met Asp Val Glu Val Asn Asn Ser Ile Gly 50 55 60 Asp Ala Ser Glu Arg Ala Thr Tyr Lys Ala Lys Leu Arg Glu Trp Lys 65 70 75 80 Lys Thr Ile Gln Ser Asp Ile Lys Arg Pro Leu Gln Ser Leu Val Asp 85 90 95 Ser Gly Asp Arg Asp Arg Leu Phe Gly Asp Leu Asn Ala Ser Asn Ile 100 105 110 Asp Asp Asp Gln Arg Gln Gln Leu Leu Ser Asn His Ala Ile Leu Gln 115 120 125 Lys Ser Gly Asp Arg Leu Lys Asp Ala Ser Arg Ile Ala Asn Glu Thr 130 135 140 Glu Gly Ile Gly Ser Gln Ile Met Met Asp Leu Arg Ser Gln Arg Glu 145 150 155 160 Thr Leu Glu Asn Ala Arg Gln Thr Leu Phe Gln Ala Asp Ser Tyr Val 165 170 175 Asp Lys Ser Ile Lys Thr Leu Lys Thr Met Thr Arg Arg Leu Val Ala 180 185 190 Asn Lys Phe Ile Ser Tyr Ala Ile Ile Ala Val Leu Ile Leu Leu Ile 195 200 205 Leu Leu Val Leu Phe Ser Lys Phe Lys 210 215 <210> 155 <211> 1863 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1863) <400> 155 atg aga gac tct aat cat cga tca tta acg tcg aac aag cct ata gta 48 Met Arg Asp Ser Asn His Arg Ser Leu Thr Ser Asn Lys Pro Ile Val Page 216 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 aca ata aca tct act gtc tat gac cga agg gca ttg gat atc aac tct 96 Thr Ile Thr Ser Thr Val Tyr Asp Arg Arg Ala Leu Asp Ile Asn Ser 20 25 30 agt att ccg tta ata aac tcc cta aac tac tta aca tat cta acc tct 144 Ser Ile Pro Leu Ile Asn Ser Leu Asn Tyr Leu Thr Tyr Leu Thr Ser 35 40 45 aat tca tca aaa gtt agg gaa acg gta gct aac gac ggt gct ctc gaa 192 Asn Ser Ser Lys Val Arg Glu Thr Val Ala Asn Asp Gly Ala Leu Glu 50 55 60 aga tta gtc tca ata ttg agg agt tgt cat tta agt ttg ttt gag ttg 240 Arg Leu Val Ser Ile Leu Arg Ser Cys His Leu Ser Leu Phe Glu Leu 65 70 75 80 ctg gat ttg gat tta gaa aat ttt aat gag cac gaa aac ata aag gat 288 Leu Asp Leu Asp Leu Glu Asn Phe Asn Glu His Glu Asn Ile Lys Asp 85 90 95 cta tgg aag gag aaa aga cta gca cta tgc gct tgg aaa tgg act tta 336 Leu Trp Lys Glu Lys Arg Leu Ala Leu Cys Ala Trp Lys Trp Thr Leu 100 105 110 aca ttt cag tgc tta gta ttg aca ggt act aga ggg aca gaa caa att 384 Thr Phe Gln Cys Leu Val Leu Thr Gly Thr Arg Gly Thr Glu Gln Ile 115 120 125 cgt aaa aaa gtg gta atg tct ggg gtc tta tct gtg ctg gtc aca gta 432 Arg Lys Lys Val Val Met Ser Gly Val Leu Ser Val Leu Val Thr Val 130 135 140 ttg gat aac tat tta cta tat cat aaa aat tac gac ttc atc aaa gat 480 Leu Asp Asn Tyr Leu Leu Tyr His Lys Asn Tyr Asp Phe Ile Lys Asp 145 150 155 160 caa aca atg acc ttt gac ttc aaa ggg ata acc acg gag aca atg tat 528 Gln Thr Met Thr Phe Asp Phe Lys Gly Ile Thr Thr Glu Thr Met Tyr 165 170 175 aaa ttc atg aga aaa gat gag aat gaa aca tat cag cag tat ata gag 576 Lys Phe Met Arg Lys Asp Glu Asn Glu Thr Tyr Gln Gln Tyr Ile Glu 180 185 190 ttc att aca ggt cag gat aaa ttg aag ttg tca act gac aaa aat ttt 624 Phe Ile Thr Gly Gln Asp Lys Leu Lys Leu Ser Thr Asp Lys Asn Phe 195 200 205 cta aac gaa cga tta gtg gca ccg tct atg aca att cca act gat ttt 672 Leu Asn Glu Arg Leu Val Ala Pro Ser Met Thr Ile Pro Thr Asp Phe 210 215 220 agt gat ata tgg ggc cgg ttt gca gac cta gct agc aat ttt gaa cct 720 Ser Asp Ile Trp Gly Arg Phe Ala Asp Leu Ala Ser Asn Phe Glu Pro 225 230 235 240 gac cag gaa aga cac gac gac gac att gat att gat agt gaa gta gaa 768 Asp Gln Glu Arg His Asp Asp Asp Ile Asp Ile Asp Ser Glu Val Glu 245 250 255 agt gaa aat ttt gat gca cat aag aat ttc ttt tcg caa cca gac att 816 Ser Glu Asn Phe Asp Ala His Lys Asn Phe Phe Ser Gln Pro Asp Ile 260 265 270 aat aga cct aca att tcc act cca cgt gaa ttt ttt ctc gga aga att 864 Asn Arg Pro Thr Ile Ser Thr Pro Arg Glu Phe Phe Leu Gly Arg Ile Page 217 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 275 280 285 gtc ccc aaa caa gac gac gtt ata tgg tcg ctt cag tta tta gct ttt 912 Val Pro Lys Gln Asp Asp Val Ile Trp Ser Leu Gln Leu Leu Ala Phe 290 295 300 gtt tcg aag tat aca tat atg aaa tca acc ctt caa aat gtt gag ctg 960 Val Ser Lys Tyr Thr Tyr Met Lys Ser Thr Leu Gln Asn Val Glu Leu 305 310 315 320 gtt gaa tcc cta tcg ttc aga agt atg gct tac aaa att aaa cag aga 1008 Val Glu Ser Leu Ser Phe Arg Ser Met Ala Tyr Lys Ile Lys Gln Arg 325 330 335 atc tca gaa gag aat gac tta gaa gaa caa gaa aga gac gta act gta 1056 Ile Ser Glu Glu Asn Asp Leu Glu Glu Gln Glu Arg Asp Val Thr Val 340 345 350 aaa ttg tct tca tta tat cct tat tta tcg aaa aat cct gaa aac aat 1104 Lys Leu Ser Ser Leu Tyr Pro Tyr Leu Ser Lys Asn Pro Glu Asn Asn 355 360 365 tcc aaa gtt aag gca cta gat act agc aaa atg gat cca ttt ttc aaa 1152 Ser Lys Val Lys Ala Leu Asp Thr Ser Lys Met Asp Pro Phe Phe Lys 370 375 380 gaa tta gaa gaa ctc tca aac aga tgt caa caa gaa gaa caa aat gaa 1200 Glu Leu Glu Glu Leu Ser Asn Arg Cys Gln Gln Glu Glu Gln Asn Glu 385 390 395 400 ata tgt aat aac cac tgt ccc gtt ctt aat ttg ttt gag cgc tac cgt 1248 Ile Cys Asn Asn His Cys Pro Val Leu Asn Leu Phe Glu Arg Tyr Arg 405 410 415 gta ccg aaa cct agc gac gac aat gcc tat ggc aaa gac aag gaa aga 1296 Val Pro Lys Pro Ser Asp Asp Asn Ala Tyr Gly Lys Asp Lys Glu Arg 420 425 430 att aat tta agg aag aaa ata tct gat aac ttt gaa agg cgc tgg agc 1344 Ile Asn Leu Arg Lys Lys Ile Ser Asp Asn Phe Glu Arg Arg Trp Ser 435 440 445 tac gat aaa atg aaa aag gaa tta aca aat att gtt tac aaa aac aag 1392 Tyr Asp Lys Met Lys Lys Glu Leu Thr Asn Ile Val Tyr Lys Asn Lys 450 455 460 gta cta aca aat gtt gta aac atc ttc ccc tta gtc gaa aaa tat aca 1440 Val Leu Thr Asn Val Val Asn Ile Phe Pro Leu Val Glu Lys Tyr Thr 465 470 475 480 gtg agc gca gaa aat aca cat gat gtt ata tat tgg agt tct gtc atc 1488 Val Ser Ala Glu Asn Thr His Asp Val Ile Tyr Trp Ser Ser Val Ile 485 490 495 atg aga aat tca tgt cga aaa aat gag atc tta ggt gtg cgt cag tgt 1536 Met Arg Asn Ser Cys Arg Lys Asn Glu Ile Leu Gly Val Arg Gln Cys 500 505 510 gcc aat ttt tcg tgc gga aaa tgg gaa gat ttt cca aga caa ttt gca 1584 Ala Asn Phe Ser Cys Gly Lys Trp Glu Asp Phe Pro Arg Gln Phe Ala 515 520 525 aaa tgt cgt cga tgc aaa aga acg aaa tat tgc tca cga aag tgt caa 1632 Lys Cys Arg Arg Cys Lys Arg Thr Lys Tyr Cys Ser Arg Lys Cys Gln 530 535 540 tta aaa gca tgg gga tat cat agg tat tgg tgt cac gaa gtt gga tca 1680 Leu Lys Ala Trp Gly Tyr His Arg Tyr Trp Cys His Glu Val Gly Ser Page 218 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 545 550 555 560 agt cat atg aga tcc acg aat act acc aca ggt gtc aat acc cca aat 1728 Ser His Met Arg Ser Thr Asn Thr Thr Thr Gly Val Asn Thr Pro Asn 565 570 575 gag cct agt tct tta aat gcc acc gct act aca gca gct gat gtt tcg 1776 Glu Pro Ser Ser Leu Asn Ala Thr Ala Thr Thr Ala Ala Asp Val Ser 580 585 590 aat tct acc agt acg ttc act cct aat ata tcc acc acc gta cct gat 1824 Asn Ser Thr Ser Thr Phe Thr Pro Asn Ile Ser Thr Thr Val Pro Asp 595 600 605 gaa ata agc aat agg gat gaa aat agc ata cct gag taa 1863 Glu Ile Ser Asn Arg Asp Glu Asn Ser Ile Pro Glu 610 615 620 <210> 156 <211> 620 <212> PRT <213> Saccharomyces cerevisiae <400> 156 Met Arg Asp Ser Asn His Arg Ser Leu Thr Ser Asn Lys Pro Ile Val 1 5 10 15 Thr Ile Thr Ser Thr Val Tyr Asp Arg Arg Ala Leu Asp Ile Asn Ser 20 25 30 Ser Ile Pro Leu Ile Asn Ser Leu Asn Tyr Leu Thr Tyr Leu Thr Ser 35 40 45 Asn Ser Ser Lys Val Arg Glu Thr Val Ala Asn Asp Gly Ala Leu Glu 50 55 60 Arg Leu Val Ser Ile Leu Arg Ser Cys His Leu Ser Leu Phe Glu Leu 65 70 75 80 Leu Asp Leu Asp Leu Glu Asn Phe Asn Glu His Glu Asn Ile Lys Asp 85 90 95 Leu Trp Lys Glu Lys Arg Leu Ala Leu Cys Ala Trp Lys Trp Thr Leu 100 105 110 Thr Phe Gln Cys Leu Val Leu Thr Gly Thr Arg Gly Thr Glu Gln Ile 115 120 125 Arg Lys Lys Val Val Met Ser Gly Val Leu Ser Val Leu Val Thr Val 130 135 140 Leu Asp Asn Tyr Leu Leu Tyr His Lys Asn Tyr Asp Phe Ile Lys Asp 145 150 155 160 Gln Thr Met Thr Phe Asp Phe Lys Gly Ile Thr Thr Glu Thr Met Tyr 165 170 175 Page 219 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Phe Met Arg Lys Asp Glu Asn Glu Thr Tyr Gln Gln Tyr Ile Glu 180 185 190 Phe Ile Thr Gly Gln Asp Lys Leu Lys Leu Ser Thr Asp Lys Asn Phe 195 200 205 Leu Asn Glu Arg Leu Val Ala Pro Ser Met Thr Ile Pro Thr Asp Phe 210 215 220 Ser Asp Ile Trp Gly Arg Phe Ala Asp Leu Ala Ser Asn Phe Glu Pro 225 230 235 240 Asp Gln Glu Arg His Asp Asp Asp Ile Asp Ile Asp Ser Glu Val Glu 245 250 255 Ser Glu Asn Phe Asp Ala His Lys Asn Phe Phe Ser Gln Pro Asp Ile 260 265 270 Asn Arg Pro Thr Ile Ser Thr Pro Arg Glu Phe Phe Leu Gly Arg Ile 275 280 285 Val Pro Lys Gln Asp Asp Val Ile Trp Ser Leu Gln Leu Leu Ala Phe 290 295 300 Val Ser Lys Tyr Thr Tyr Met Lys Ser Thr Leu Gln Asn Val Glu Leu 305 310 315 320 Val Glu Ser Leu Ser Phe Arg Ser Met Ala Tyr Lys Ile Lys Gln Arg 325 330 335 Ile Ser Glu Glu Asn Asp Leu Glu Glu Gln Glu Arg Asp Val Thr Val 340 345 350 Lys Leu Ser Ser Leu Tyr Pro Tyr Leu Ser Lys Asn Pro Glu Asn Asn 355 360 365 Ser Lys Val Lys Ala Leu Asp Thr Ser Lys Met Asp Pro Phe Phe Lys 370 375 380 Glu Leu Glu Glu Leu Ser Asn Arg Cys Gln Gln Glu Glu Gln Asn Glu 385 390 395 400 Ile Cys Asn Asn His Cys Pro Val Leu Asn Leu Phe Glu Arg Tyr Arg 405 410 415 Val Pro Lys Pro Ser Asp Asp Asn Ala Tyr Gly Lys Asp Lys Glu Arg 420 425 430 Ile Asn Leu Arg Lys Lys Ile Ser Asp Asn Phe Glu Arg Arg Trp Ser 435 440 445 Page 220 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Tyr Asp Lys Met Lys Lys Glu Leu Thr Asn Ile Val Tyr Lys Asn Lys 450 455 460 Val Leu Thr Asn Val Val Asn Ile Phe Pro Leu Val Glu Lys Tyr Thr 465 470 475 480 Val Ser Ala Glu Asn Thr His Asp Val Ile Tyr Trp Ser Ser Val Ile 485 490 495 Met Arg Asn Ser Cys Arg Lys Asn Glu Ile Leu Gly Val Arg Gln Cys 500 505 510 Ala Asn Phe Ser Cys Gly Lys Trp Glu Asp Phe Pro Arg Gln Phe Ala 515 520 525 Lys Cys Arg Arg Cys Lys Arg Thr Lys Tyr Cys Ser Arg Lys Cys Gln 530 535 540 Leu Lys Ala Trp Gly Tyr His Arg Tyr Trp Cys His Glu Val Gly Ser 545 550 555 560 Ser His Met Arg Ser Thr Asn Thr Thr Thr Gly Val Asn Thr Pro Asn 565 570 575 Glu Pro Ser Ser Leu Asn Ala Thr Ala Thr Thr Ala Ala Asp Val Ser 580 585 590 Asn Ser Thr Ser Thr Phe Thr Pro Asn Ile Ser Thr Thr Val Pro Asp 595 600 605 Glu Ile Ser Asn Arg Asp Glu Asn Ser Ile Pro Glu 610 615 620 <210> 157 <211> 1350 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1350) <400> 157 atg cgt cta aaa gaa ttg tta cct aat ttt ttg att gtt cat caa gag 48 Met Arg Leu Lys Glu Leu Leu Pro Asn Phe Leu Ile Val His Gln Glu 1 5 10 15 gtc cct gag gat cct att gca ttc aag tcc acc gat aaa cga gag aat 96 Val Pro Glu Asp Pro Ile Ala Phe Lys Ser Thr Asp Lys Arg Glu Asn 20 25 30 gaa aat aaa gag atc acc atc cct gag cta ata gat act aaa gtt cct 144 Glu Asn Lys Glu Ile Thr Ile Pro Glu Leu Ile Asp Thr Lys Val Pro 35 40 45 Page 221 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa tta gct gac ggt gct act gac act tta tat ggt tta ctg gtc aat 192 Glu Leu Ala Asp Gly Ala Thr Asp Thr Leu Tyr Gly Leu Leu Val Asn 50 55 60 ggc cat tta caa act gca tat ggt tcc ttt aga cac ttt gac aat ata 240 Gly His Leu Gln Thr Ala Tyr Gly Ser Phe Arg His Phe Asp Asn Ile 65 70 75 80 tac aaa gtt caa tat aaa aga atg ata atc aaa tac cca cat ggg gga 288 Tyr Lys Val Gln Tyr Lys Arg Met Ile Ile Lys Tyr Pro His Gly Gly 85 90 95 gaa ggg act gtg gat ttt gct gta aat ggt aga agt acc aaa aga aga 336 Glu Gly Thr Val Asp Phe Ala Val Asn Gly Arg Ser Thr Lys Arg Arg 100 105 110 aaa gtg gaa aaa gaa tac gtg ccg aca agt caa ccg gta ttt aac gga 384 Lys Val Glu Lys Glu Tyr Val Pro Thr Ser Gln Pro Val Phe Asn Gly 115 120 125 aac ttg aaa cga aga tat tcg tac tat tcc cct gat gat cct aaa ttg 432 Asn Leu Lys Arg Arg Tyr Ser Tyr Tyr Ser Pro Asp Asp Pro Lys Leu 130 135 140 aac tca gac gat gct aag cct atg ctt att att ctc cat gga tta aca 480 Asn Ser Asp Asp Ala Lys Pro Met Leu Ile Ile Leu His Gly Leu Thr 145 150 155 160 ggg ggt tcg agg gaa agc tac gtg agg gca att gtt cat gaa atc acc 528 Gly Gly Ser Arg Glu Ser Tyr Val Arg Ala Ile Val His Glu Ile Thr 165 170 175 acg aag tat gac ttt gaa gca tgc gtg ttt aat gct aga gga tgt tgt 576 Thr Lys Tyr Asp Phe Glu Ala Cys Val Phe Asn Ala Arg Gly Cys Cys 180 185 190 tat tct gca att aca acg ccg cta tta tac aac ggt ggt tgg acc aat 624 Tyr Ser Ala Ile Thr Thr Pro Leu Leu Tyr Asn Gly Gly Trp Thr Asn 195 200 205 gat ata aga tat tgt gtt aat gac ttg agg aaa aga ttt ccg aat aga 672 Asp Ile Arg Tyr Cys Val Asn Asp Leu Arg Lys Arg Phe Pro Asn Arg 210 215 220 aag ttt tat atg atg gga ttt tcg tta ggc gca tct ata atg aca aat 720 Lys Phe Tyr Met Met Gly Phe Ser Leu Gly Ala Ser Ile Met Thr Asn 225 230 235 240 tac ttg gga gaa gag tca gat cgt act aaa atc gaa tgt gct att tcc 768 Tyr Leu Gly Glu Glu Ser Asp Arg Thr Lys Ile Glu Cys Ala Ile Ser 245 250 255 gtg agt aat cca ttt gac ctg tac aac tct gca tat ttt att aac agt 816 Val Ser Asn Pro Phe Asp Leu Tyr Asn Ser Ala Tyr Phe Ile Asn Ser 260 265 270 aca cca atg ggg tca cga ttt tat tca cct gct ttg ggt cac aac tta 864 Thr Pro Met Gly Ser Arg Phe Tyr Ser Pro Ala Leu Gly His Asn Leu 275 280 285 cta cgc atg gtt cga aac cat ctc tct act ctg gaa gaa aac cct gat 912 Leu Arg Met Val Arg Asn His Leu Ser Thr Leu Glu Glu Asn Pro Asp 290 295 300 ttc aaa gat gtt atc gag aag cat tta aaa aag att cgc act gtg agg 960 Phe Lys Asp Val Ile Glu Lys His Leu Lys Lys Ile Arg Thr Val Arg 305 310 315 320 Page 222 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt caa ttt gat aac ttg ttg aca ggc cca atg ttt gga tat aaa aat gca 1008 Gln Phe Asp Asn Leu Leu Thr Gly Pro Met Phe Gly Tyr Lys Asn Ala 325 330 335 gag gag tat tac aag aat gct tca tca tat aaa aga ata ccc ggg atc 1056 Glu Glu Tyr Tyr Lys Asn Ala Ser Ser Tyr Lys Arg Ile Pro Gly Ile 340 345 350 aga act cct ttt ata gct ttg cat gct cag gat gac cca att gtc gga 1104 Arg Thr Pro Phe Ile Ala Leu His Ala Gln Asp Asp Pro Ile Val Gly 355 360 365 ggt gat ctt cct ata gac caa ata aaa tcc aat cca tac act ttg ctt 1152 Gly Asp Leu Pro Ile Asp Gln Ile Lys Ser Asn Pro Tyr Thr Leu Leu 370 375 380 cta gaa act tcg acg ggg ggg cat gtt gga tgg ttc aaa gac aga tcc 1200 Leu Glu Thr Ser Thr Gly Gly His Val Gly Trp Phe Lys Asp Arg Ser 385 390 395 400 ggc aga agg tgg tac gca gaa ccc tta tgc aga ttt ttg aaa ata ttt 1248 Gly Arg Arg Trp Tyr Ala Glu Pro Leu Cys Arg Phe Leu Lys Ile Phe 405 410 415 cac gac gaa att act gta aag ggc tta aaa cct gac ttg gaa aat gtt 1296 His Asp Glu Ile Thr Val Lys Gly Leu Lys Pro Asp Leu Glu Asn Val 420 425 430 caa ctc cca gat cct aat tgc gaa ccc ata gcc aca acc ttt cgc gcg 1344 Gln Leu Pro Asp Pro Asn Cys Glu Pro Ile Ala Thr Thr Phe Arg Ala 435 440 445 aat tag 1350 Asn <210> 158 <211> 449 <212> PRT <213> Saccharomyces cerevisiae <400> 158 Met Arg Leu Lys Glu Leu Leu Pro Asn Phe Leu Ile Val His Gln Glu 1 5 10 15 Val Pro Glu Asp Pro Ile Ala Phe Lys Ser Thr Asp Lys Arg Glu Asn 20 25 30 Glu Asn Lys Glu Ile Thr Ile Pro Glu Leu Ile Asp Thr Lys Val Pro 35 40 45 Glu Leu Ala Asp Gly Ala Thr Asp Thr Leu Tyr Gly Leu Leu Val Asn 50 55 60 Gly His Leu Gln Thr Ala Tyr Gly Ser Phe Arg His Phe Asp Asn Ile 65 70 75 80 Tyr Lys Val Gln Tyr Lys Arg Met Ile Ile Lys Tyr Pro His Gly Gly 85 90 95 Page 223 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Gly Thr Val Asp Phe Ala Val Asn Gly Arg Ser Thr Lys Arg Arg 100 105 110 Lys Val Glu Lys Glu Tyr Val Pro Thr Ser Gln Pro Val Phe Asn Gly 115 120 125 Asn Leu Lys Arg Arg Tyr Ser Tyr Tyr Ser Pro Asp Asp Pro Lys Leu 130 135 140 Asn Ser Asp Asp Ala Lys Pro Met Leu Ile Ile Leu His Gly Leu Thr 145 150 155 160 Gly Gly Ser Arg Glu Ser Tyr Val Arg Ala Ile Val His Glu Ile Thr 165 170 175 Thr Lys Tyr Asp Phe Glu Ala Cys Val Phe Asn Ala Arg Gly Cys Cys 180 185 190 Tyr Ser Ala Ile Thr Thr Pro Leu Leu Tyr Asn Gly Gly Trp Thr Asn 195 200 205 Asp Ile Arg Tyr Cys Val Asn Asp Leu Arg Lys Arg Phe Pro Asn Arg 210 215 220 Lys Phe Tyr Met Met Gly Phe Ser Leu Gly Ala Ser Ile Met Thr Asn 225 230 235 240 Tyr Leu Gly Glu Glu Ser Asp Arg Thr Lys Ile Glu Cys Ala Ile Ser 245 250 255 Val Ser Asn Pro Phe Asp Leu Tyr Asn Ser Ala Tyr Phe Ile Asn Ser 260 265 270 Thr Pro Met Gly Ser Arg Phe Tyr Ser Pro Ala Leu Gly His Asn Leu 275 280 285 Leu Arg Met Val Arg Asn His Leu Ser Thr Leu Glu Glu Asn Pro Asp 290 295 300 Phe Lys Asp Val Ile Glu Lys His Leu Lys Lys Ile Arg Thr Val Arg 305 310 315 320 Gln Phe Asp Asn Leu Leu Thr Gly Pro Met Phe Gly Tyr Lys Asn Ala 325 330 335 Glu Glu Tyr Tyr Lys Asn Ala Ser Ser Tyr Lys Arg Ile Pro Gly Ile 340 345 350 Arg Thr Pro Phe Ile Ala Leu His Ala Gln Asp Asp Pro Ile Val Gly 355 360 365 Page 224 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Asp Leu Pro Ile Asp Gln Ile Lys Ser Asn Pro Tyr Thr Leu Leu 370 375 380 Leu Glu Thr Ser Thr Gly Gly His Val Gly Trp Phe Lys Asp Arg Ser 385 390 395 400 Gly Arg Arg Trp Tyr Ala Glu Pro Leu Cys Arg Phe Leu Lys Ile Phe 405 410 415 His Asp Glu Ile Thr Val Lys Gly Leu Lys Pro Asp Leu Glu Asn Val 420 425 430 Gln Leu Pro Asp Pro Asn Cys Glu Pro Ile Ala Thr Thr Phe Arg Ala 435 440 445 Asn <210> 159 <211> 1083 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1083) <400> 159 atg tct tat cct gag aaa ttt gaa ggt atc gct att caa tca cac gaa 48 Met Ser Tyr Pro Glu Lys Phe Glu Gly Ile Ala Ile Gln Ser His Glu 1 5 10 15 gat tgg aaa aac cca aag aag aca aag tat gac cca aaa cca ttt tac 96 Asp Trp Lys Asn Pro Lys Lys Thr Lys Tyr Asp Pro Lys Pro Phe Tyr 20 25 30 gat cat gac att gac att aag atc gaa gca tgt ggt gtc tgc ggt agt 144 Asp His Asp Ile Asp Ile Lys Ile Glu Ala Cys Gly Val Cys Gly Ser 35 40 45 gat att cat tgt gca gct ggt cat tgg ggc aat atg aag atg ccg cta 192 Asp Ile His Cys Ala Ala Gly His Trp Gly Asn Met Lys Met Pro Leu 50 55 60 gtc gtt ggt cat gaa atc gtt ggt aaa gtt gtc aag cta ggg ccc aag 240 Val Val Gly His Glu Ile Val Gly Lys Val Val Lys Leu Gly Pro Lys 65 70 75 80 tca aac agt ggg ttg aaa gtc ggt caa cgt gtt ggt gta ggt gct caa 288 Ser Asn Ser Gly Leu Lys Val Gly Gln Arg Val Gly Val Gly Ala Gln 85 90 95 gtc ttt tca tgc ttg gaa tgt gac cgt tgt aag aat gat aat gaa cca 336 Val Phe Ser Cys Leu Glu Cys Asp Arg Cys Lys Asn Asp Asn Glu Pro 100 105 110 tac tgc acc aag ttt gtt acc aca tac agt cag cct tat gaa gac ggc 384 Tyr Cys Thr Lys Phe Val Thr Thr Tyr Ser Gln Pro Tyr Glu Asp Gly 115 120 125 Page 225 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tat gtg tcg cag ggt ggc tat gca aac tac gtc aga gtt cat gaa cat 432 Tyr Val Ser Gln Gly Gly Tyr Ala Asn Tyr Val Arg Val His Glu His 130 135 140 ttt gtg gtg cct atc cca gag aat att cca tca cat ttg gct gct cca 480 Phe Val Val Pro Ile Pro Glu Asn Ile Pro Ser His Leu Ala Ala Pro 145 150 155 160 cta tta tgt ggt ggt ttg act gtg tac tct cca ttg gtt cgt aac ggt 528 Leu Leu Cys Gly Gly Leu Thr Val Tyr Ser Pro Leu Val Arg Asn Gly 165 170 175 tgc ggt cca ggt aaa aaa gtt ggt ata gtt ggt ctt ggt ggt atc ggc 576 Cys Gly Pro Gly Lys Lys Val Gly Ile Val Gly Leu Gly Gly Ile Gly 180 185 190 agt atg ggt aca ttg att tcc aaa gcc atg ggg gca gag acg tat gtt 624 Ser Met Gly Thr Leu Ile Ser Lys Ala Met Gly Ala Glu Thr Tyr Val 195 200 205 att tct cgt tct tcg aga aaa aga gaa gat gca atg aag atg ggc gcc 672 Ile Ser Arg Ser Ser Arg Lys Arg Glu Asp Ala Met Lys Met Gly Ala 210 215 220 gat cac tac att gct aca tta gaa gaa ggt gat tgg ggt gaa aag tac 720 Asp His Tyr Ile Ala Thr Leu Glu Glu Gly Asp Trp Gly Glu Lys Tyr 225 230 235 240 ttt gac acc ttc gac ctg att gta gtc tgt gct tcc tcc ctt acc gac 768 Phe Asp Thr Phe Asp Leu Ile Val Val Cys Ala Ser Ser Leu Thr Asp 245 250 255 att gac ttc aac att atg cca aag gct atg aag gtt ggt ggt aga att 816 Ile Asp Phe Asn Ile Met Pro Lys Ala Met Lys Val Gly Gly Arg Ile 260 265 270 gtc tca atc tct ata cca gaa caa cac gaa atg tta tcg cta aag cca 864 Val Ser Ile Ser Ile Pro Glu Gln His Glu Met Leu Ser Leu Lys Pro 275 280 285 tat ggc tta aag gct gtc tcc att tct tac agt gct tta ggt tcc atc 912 Tyr Gly Leu Lys Ala Val Ser Ile Ser Tyr Ser Ala Leu Gly Ser Ile 290 295 300 aaa gaa ttg aac caa ctc ttg aaa tta gtc tct gaa aaa gat atc aaa 960 Lys Glu Leu Asn Gln Leu Leu Lys Leu Val Ser Glu Lys Asp Ile Lys 305 310 315 320 att tgg gtg gaa aca tta cct gtt ggt gaa gcc ggc gtc cat gaa gcc 1008 Ile Trp Val Glu Thr Leu Pro Val Gly Glu Ala Gly Val His Glu Ala 325 330 335 ttc gaa agg atg gaa aag ggt gac gtt aga tat aga ttt acc tta gtc 1056 Phe Glu Arg Met Glu Lys Gly Asp Val Arg Tyr Arg Phe Thr Leu Val 340 345 350 ggc tac gac aaa gaa ttt tca gac tag 1083 Gly Tyr Asp Lys Glu Phe Ser Asp 355 360 <210> 160 <211> 360 <212> PRT <213> Saccharomyces cerevisiae <400> 160 Page 226 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Ser Tyr Pro Glu Lys Phe Glu Gly Ile Ala Ile Gln Ser His Glu 1 5 10 15 Asp Trp Lys Asn Pro Lys Lys Thr Lys Tyr Asp Pro Lys Pro Phe Tyr 20 25 30 Asp His Asp Ile Asp Ile Lys Ile Glu Ala Cys Gly Val Cys Gly Ser 35 40 45 Asp Ile His Cys Ala Ala Gly His Trp Gly Asn Met Lys Met Pro Leu 50 55 60 Val Val Gly His Glu Ile Val Gly Lys Val Val Lys Leu Gly Pro Lys 65 70 75 80 Ser Asn Ser Gly Leu Lys Val Gly Gln Arg Val Gly Val Gly Ala Gln 85 90 95 Val Phe Ser Cys Leu Glu Cys Asp Arg Cys Lys Asn Asp Asn Glu Pro 100 105 110 Tyr Cys Thr Lys Phe Val Thr Thr Tyr Ser Gln Pro Tyr Glu Asp Gly 115 120 125 Tyr Val Ser Gln Gly Gly Tyr Ala Asn Tyr Val Arg Val His Glu His 130 135 140 Phe Val Val Pro Ile Pro Glu Asn Ile Pro Ser His Leu Ala Ala Pro 145 150 155 160 Leu Leu Cys Gly Gly Leu Thr Val Tyr Ser Pro Leu Val Arg Asn Gly 165 170 175 Cys Gly Pro Gly Lys Lys Val Gly Ile Val Gly Leu Gly Gly Ile Gly 180 185 190 Ser Met Gly Thr Leu Ile Ser Lys Ala Met Gly Ala Glu Thr Tyr Val 195 200 205 Ile Ser Arg Ser Ser Arg Lys Arg Glu Asp Ala Met Lys Met Gly Ala 210 215 220 Asp His Tyr Ile Ala Thr Leu Glu Glu Gly Asp Trp Gly Glu Lys Tyr 225 230 235 240 Phe Asp Thr Phe Asp Leu Ile Val Val Cys Ala Ser Ser Leu Thr Asp 245 250 255 Ile Asp Phe Asn Ile Met Pro Lys Ala Met Lys Val Gly Gly Arg Ile 260 265 270 Page 227 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Ser Ile Ser Ile Pro Glu Gln His Glu Met Leu Ser Leu Lys Pro 275 280 285 Tyr Gly Leu Lys Ala Val Ser Ile Ser Tyr Ser Ala Leu Gly Ser Ile 290 295 300 Lys Glu Leu Asn Gln Leu Leu Lys Leu Val Ser Glu Lys Asp Ile Lys 305 310 315 320 Ile Trp Val Glu Thr Leu Pro Val Gly Glu Ala Gly Val His Glu Ala 325 330 335 Phe Glu Arg Met Glu Lys Gly Asp Val Arg Tyr Arg Phe Thr Leu Val 340 345 350 Gly Tyr Asp Lys Glu Phe Ser Asp 355 360 <210> 161 <211> 858 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(858) <400> 161 atg cgt tct tcg gta tat agt gag aac act tac aac tgt ata cga aca 48 Met Arg Ser Ser Val Tyr Ser Glu Asn Thr Tyr Asn Cys Ile Arg Thr 1 5 10 15 tcg aag gag cac cta aca gaa aga agg agg gtc gcc atg gcg cca atg 96 Ser Lys Glu His Leu Thr Glu Arg Arg Arg Val Ala Met Ala Pro Met 20 25 30 ttc caa cat ttc tta aac tta tgc gtg gaa aaa ttt cct gaa tcc atc 144 Phe Gln His Phe Leu Asn Leu Cys Val Glu Lys Phe Pro Glu Ser Ile 35 40 45 gag cac aag gat aca gat gga aac ggt aac ttc acc acc gct att tta 192 Glu His Lys Asp Thr Asp Gly Asn Gly Asn Phe Thr Thr Ala Ile Leu 50 55 60 gaa agg gag att atc tac atc ccc gaa gat gac act gac agt att gac 240 Glu Arg Glu Ile Ile Tyr Ile Pro Glu Asp Asp Thr Asp Ser Ile Asp 65 70 75 80 agc gtt gac agc ctc aag tgt ata aac tac aag ctg cac aaa tct cgc 288 Ser Val Asp Ser Leu Lys Cys Ile Asn Tyr Lys Leu His Lys Ser Arg 85 90 95 ggc gac caa gtg ctg gac gcc tgt gtg caa ttg ata gac aag cac ctg 336 Gly Asp Gln Val Leu Asp Ala Cys Val Gln Leu Ile Asp Lys His Leu 100 105 110 ggc gcc aag tat cgc cgg gcc tcg cgc att atg tac ggc aac agg aaa 384 Gly Ala Lys Tyr Arg Arg Ala Ser Arg Ile Met Tyr Gly Asn Arg Lys 115 120 125 cca tgg aag gca aac aaa ctc gca gag atg aaa agc gcc ggc ctt gtg 432 Page 228 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Trp Lys Ala Asn Lys Leu Ala Glu Met Lys Ser Ala Gly Leu Val 130 135 140 tat gtc tgt tac tgg gac aac ggc gtg cta ggt gca ttt act tca ttc 480 Tyr Val Cys Tyr Trp Asp Asn Gly Val Leu Gly Ala Phe Thr Ser Phe 145 150 155 160 atg ctt aca gag gag acg ggt ctc gtc gaa ggt gac gct tta cac gag 528 Met Leu Thr Glu Glu Thr Gly Leu Val Glu Gly Asp Ala Leu His Glu 165 170 175 gtt agc gtg ccc gtg ata tac ctt tac gaa gta cat gta gct agc gcg 576 Val Ser Val Pro Val Ile Tyr Leu Tyr Glu Val His Val Ala Ser Ala 180 185 190 cac cgc ggg cat gga atc ggt cgg cgg cta ctg gag cat gca ctg tgc 624 His Arg Gly His Gly Ile Gly Arg Arg Leu Leu Glu His Ala Leu Cys 195 200 205 gat ggc gta gct cga cac acc cgc cgc atg tgc gac aat ttc ttc ggt 672 Asp Gly Val Ala Arg His Thr Arg Arg Met Cys Asp Asn Phe Phe Gly 210 215 220 gta gca ctc acc gta ttc agt gat aac act cgg gcc cgg cga cta tat 720 Val Ala Leu Thr Val Phe Ser Asp Asn Thr Arg Ala Arg Arg Leu Tyr 225 230 235 240 gag gcg ctt ggg ttc tac cgc gct ccg gga tca ccc gca cca gca tca 768 Glu Ala Leu Gly Phe Tyr Arg Ala Pro Gly Ser Pro Ala Pro Ala Ser 245 250 255 ccc aca att cgt cac acg cga cat ggt ggg gga cgt gta gtc gtg ccc 816 Pro Thr Ile Arg His Thr Arg His Gly Gly Gly Arg Val Val Val Pro 260 265 270 tgc gat ccg ctt tat tac gta tat tgc ctt cac atg ccg tga 858 Cys Asp Pro Leu Tyr Tyr Val Tyr Cys Leu His Met Pro 275 280 285 <210> 162 <211> 285 <212> PRT <213> Saccharomyces cerevisiae <400> 162 Met Arg Ser Ser Val Tyr Ser Glu Asn Thr Tyr Asn Cys Ile Arg Thr 1 5 10 15 Ser Lys Glu His Leu Thr Glu Arg Arg Arg Val Ala Met Ala Pro Met 20 25 30 Phe Gln His Phe Leu Asn Leu Cys Val Glu Lys Phe Pro Glu Ser Ile 35 40 45 Glu His Lys Asp Thr Asp Gly Asn Gly Asn Phe Thr Thr Ala Ile Leu 50 55 60 Glu Arg Glu Ile Ile Tyr Ile Pro Glu Asp Asp Thr Asp Ser Ile Asp 65 70 75 80 Ser Val Asp Ser Leu Lys Cys Ile Asn Tyr Lys Leu His Lys Ser Arg Page 229 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Gly Asp Gln Val Leu Asp Ala Cys Val Gln Leu Ile Asp Lys His Leu 100 105 110 Gly Ala Lys Tyr Arg Arg Ala Ser Arg Ile Met Tyr Gly Asn Arg Lys 115 120 125 Pro Trp Lys Ala Asn Lys Leu Ala Glu Met Lys Ser Ala Gly Leu Val 130 135 140 Tyr Val Cys Tyr Trp Asp Asn Gly Val Leu Gly Ala Phe Thr Ser Phe 145 150 155 160 Met Leu Thr Glu Glu Thr Gly Leu Val Glu Gly Asp Ala Leu His Glu 165 170 175 Val Ser Val Pro Val Ile Tyr Leu Tyr Glu Val His Val Ala Ser Ala 180 185 190 His Arg Gly His Gly Ile Gly Arg Arg Leu Leu Glu His Ala Leu Cys 195 200 205 Asp Gly Val Ala Arg His Thr Arg Arg Met Cys Asp Asn Phe Phe Gly 210 215 220 Val Ala Leu Thr Val Phe Ser Asp Asn Thr Arg Ala Arg Arg Leu Tyr 225 230 235 240 Glu Ala Leu Gly Phe Tyr Arg Ala Pro Gly Ser Pro Ala Pro Ala Ser 245 250 255 Pro Thr Ile Arg His Thr Arg His Gly Gly Gly Arg Val Val Val Pro 260 265 270 Cys Asp Pro Leu Tyr Tyr Val Tyr Cys Leu His Met Pro 275 280 285 <210> 163 <211> 1755 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1755) <400> 163 atg tcg cgg gag gca ttt gat gta ccg aat ata ggt act aac aag ttt 48 Met Ser Arg Glu Ala Phe Asp Val Pro Asn Ile Gly Thr Asn Lys Phe 1 5 10 15 tta aaa gtc aca cct aat tta ttt acc cca gag cga ttg aat tta ttt 96 Leu Lys Val Thr Pro Asn Leu Phe Thr Pro Glu Arg Leu Asn Leu Phe Page 230 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 gat gat gtc gaa cta tat ctt acg tta ata aaa gca tcc aaa tgt gtc 144 Asp Asp Val Glu Leu Tyr Leu Thr Leu Ile Lys Ala Ser Lys Cys Val 35 40 45 gag cag gga gaa agg ctg cac aat ata agt tgg aga att ctg aat aaa 192 Glu Gln Gly Glu Arg Leu His Asn Ile Ser Trp Arg Ile Leu Asn Lys 50 55 60 gct gtt cta aag gag cat aat att aat cga tct aaa aaa aga gac ggc 240 Ala Val Leu Lys Glu His Asn Ile Asn Arg Ser Lys Lys Arg Asp Gly 65 70 75 80 gtg aag aac ata tat tat gtg tta aat cca aac aac aaa cag cca ata 288 Val Lys Asn Ile Tyr Tyr Val Leu Asn Pro Asn Asn Lys Gln Pro Ile 85 90 95 aag cca aag cag gca gca gta aag cag cca cca tta caa aag gcc aat 336 Lys Pro Lys Gln Ala Ala Val Lys Gln Pro Pro Leu Gln Lys Ala Asn 100 105 110 ttg cct ccc aca acg gca aaa cag aac gtt tta act cgg cca atg aca 384 Leu Pro Pro Thr Thr Ala Lys Gln Asn Val Leu Thr Arg Pro Met Thr 115 120 125 tca cca gct atc gca cag ggt gct cac gat aga tcc ttg gat aat cct 432 Ser Pro Ala Ile Ala Gln Gly Ala His Asp Arg Ser Leu Asp Asn Pro 130 135 140 aat tct aca aac aat gat gtg aaa aat gac gtt gct cca aac aga caa 480 Asn Ser Thr Asn Asn Asp Val Lys Asn Asp Val Ala Pro Asn Arg Gln 145 150 155 160 ttc tcc aaa tct act acg tca ggg ttg ttt tca aat ttt gca gac aaa 528 Phe Ser Lys Ser Thr Thr Ser Gly Leu Phe Ser Asn Phe Ala Asp Lys 165 170 175 tat caa aaa atg aaa aat gtg aac cat gtt gct aat aag gaa gaa cca 576 Tyr Gln Lys Met Lys Asn Val Asn His Val Ala Asn Lys Glu Glu Pro 180 185 190 caa act att atc act ggt ttt gat aca agc act gtt ata acc aag aaa 624 Gln Thr Ile Ile Thr Gly Phe Asp Thr Ser Thr Val Ile Thr Lys Lys 195 200 205 cct tta caa tca aga cgc tca aga tca cct ttc cag cat ata gga gac 672 Pro Leu Gln Ser Arg Arg Ser Arg Ser Pro Phe Gln His Ile Gly Asp 210 215 220 atg aac atg aac tgc att gat aat gag act tcc aag agt acc agt cct 720 Met Asn Met Asn Cys Ile Asp Asn Glu Thr Ser Lys Ser Thr Ser Pro 225 230 235 240 act ctt gaa aat atg gga agt aga aaa tcc tct ttt cct cag aag gaa 768 Thr Leu Glu Asn Met Gly Ser Arg Lys Ser Ser Phe Pro Gln Lys Glu 245 250 255 tct tta ttc gga agg cca agg tct tac aag aat gac caa aat ggt caa 816 Ser Leu Phe Gly Arg Pro Arg Ser Tyr Lys Asn Asp Gln Asn Gly Gln 260 265 270 ctg tca ctt tcg aaa aca tcc tct aga aaa gga aaa aac aag ata ttt 864 Leu Ser Leu Ser Lys Thr Ser Ser Arg Lys Gly Lys Asn Lys Ile Phe 275 280 285 ttc agc agt gaa gat gaa gat tcc gat tgg gac agc gtt tcg aat gat 912 Phe Ser Ser Glu Asp Glu Asp Ser Asp Trp Asp Ser Val Ser Asn Asp Page 231 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 290 295 300 tca gaa ttc tac gct gat gaa gat gat gaa gag tac gat gat tat aat 960 Ser Glu Phe Tyr Ala Asp Glu Asp Asp Glu Glu Tyr Asp Asp Tyr Asn 305 310 315 320 gag gaa gaa gca gat cag tac tat aga aga caa tgg gac aag ctt tta 1008 Glu Glu Glu Ala Asp Gln Tyr Tyr Arg Arg Gln Trp Asp Lys Leu Leu 325 330 335 ttt gcc aaa aat caa cag aat ctt gac tca acg aaa tca tct gtt tca 1056 Phe Ala Lys Asn Gln Gln Asn Leu Asp Ser Thr Lys Ser Ser Val Ser 340 345 350 tca gcg aac aca atc aac tca aac aca tcc cat gat ccc gta cga aaa 1104 Ser Ala Asn Thr Ile Asn Ser Asn Thr Ser His Asp Pro Val Arg Lys 355 360 365 agt tta ctc agt gga cta ttc ctt agt gag gca aat agc aac agt aat 1152 Ser Leu Leu Ser Gly Leu Phe Leu Ser Glu Ala Asn Ser Asn Ser Asn 370 375 380 aac cac aat act gca cat agt gaa tac gct tct aaa cac gtt tcg ccg 1200 Asn His Asn Thr Ala His Ser Glu Tyr Ala Ser Lys His Val Ser Pro 385 390 395 400 act cct cag tcc tct cat agt aat atc ggt cct caa ccg cag caa aat 1248 Thr Pro Gln Ser Ser His Ser Asn Ile Gly Pro Gln Pro Gln Gln Asn 405 410 415 cca ccg agc gct aat ggt ata aaa caa caa aaa cct tct ttg aaa aca 1296 Pro Pro Ser Ala Asn Gly Ile Lys Gln Gln Lys Pro Ser Leu Lys Thr 420 425 430 agc aac gtg aca gct cta gca tcg cta tct ccc ccg caa cca tcc aac 1344 Ser Asn Val Thr Ala Leu Ala Ser Leu Ser Pro Pro Gln Pro Ser Asn 435 440 445 aat gag cgg tta tcg atg gat ata caa aag gac ttc aaa act gat aat 1392 Asn Glu Arg Leu Ser Met Asp Ile Gln Lys Asp Phe Lys Thr Asp Asn 450 455 460 gag tcc aat cat tta tat gaa tct aat gct ccg cta act gct caa act 1440 Glu Ser Asn His Leu Tyr Glu Ser Asn Ala Pro Leu Thr Ala Gln Thr 465 470 475 480 ata ctg ccc acc gcc tta tct act cac atg ttt ttg cca aat aac att 1488 Ile Leu Pro Thr Ala Leu Ser Thr His Met Phe Leu Pro Asn Asn Ile 485 490 495 cac caa caa cga atg gcg att gcc act ggt agt aat acg cga cat cgt 1536 His Gln Gln Arg Met Ala Ile Ala Thr Gly Ser Asn Thr Arg His Arg 500 505 510 ttt tcg agg cgg cag tcg atg gat atc cca tcc aag aac agg aat act 1584 Phe Ser Arg Arg Gln Ser Met Asp Ile Pro Ser Lys Asn Arg Asn Thr 515 520 525 ggg ttt ttg aag acc aga atg gag atc tct gag gaa gaa aag atg gta 1632 Gly Phe Leu Lys Thr Arg Met Glu Ile Ser Glu Glu Glu Lys Met Val 530 535 540 cgt aca ata tca cgg ctt gac aat acg agt att gca aac agt aat gga 1680 Arg Thr Ile Ser Arg Leu Asp Asn Thr Ser Ile Ala Asn Ser Asn Gly 545 550 555 560 aat ggt aat gat gac acc tct aat cag aga acg gaa gca ctg ggg cgt 1728 Asn Gly Asn Asp Asp Thr Ser Asn Gln Arg Thr Glu Ala Leu Gly Arg Page 232 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 565 570 575 aag acg agt aat gga ggg cga ata tga 1755 Lys Thr Ser Asn Gly Gly Arg Ile 580 <210> 164 <211> 584 <212> PRT <213> Saccharomyces cerevisiae <400> 164 Met Ser Arg Glu Ala Phe Asp Val Pro Asn Ile Gly Thr Asn Lys Phe 1 5 10 15 Leu Lys Val Thr Pro Asn Leu Phe Thr Pro Glu Arg Leu Asn Leu Phe 20 25 30 Asp Asp Val Glu Leu Tyr Leu Thr Leu Ile Lys Ala Ser Lys Cys Val 35 40 45 Glu Gln Gly Glu Arg Leu His Asn Ile Ser Trp Arg Ile Leu Asn Lys 50 55 60 Ala Val Leu Lys Glu His Asn Ile Asn Arg Ser Lys Lys Arg Asp Gly 65 70 75 80 Val Lys Asn Ile Tyr Tyr Val Leu Asn Pro Asn Asn Lys Gln Pro Ile 85 90 95 Lys Pro Lys Gln Ala Ala Val Lys Gln Pro Pro Leu Gln Lys Ala Asn 100 105 110 Leu Pro Pro Thr Thr Ala Lys Gln Asn Val Leu Thr Arg Pro Met Thr 115 120 125 Ser Pro Ala Ile Ala Gln Gly Ala His Asp Arg Ser Leu Asp Asn Pro 130 135 140 Asn Ser Thr Asn Asn Asp Val Lys Asn Asp Val Ala Pro Asn Arg Gln 145 150 155 160 Phe Ser Lys Ser Thr Thr Ser Gly Leu Phe Ser Asn Phe Ala Asp Lys 165 170 175 Tyr Gln Lys Met Lys Asn Val Asn His Val Ala Asn Lys Glu Glu Pro 180 185 190 Gln Thr Ile Ile Thr Gly Phe Asp Thr Ser Thr Val Ile Thr Lys Lys 195 200 205 Pro Leu Gln Ser Arg Arg Ser Arg Ser Pro Phe Gln His Ile Gly Asp 210 215 220 Page 233 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Asn Met Asn Cys Ile Asp Asn Glu Thr Ser Lys Ser Thr Ser Pro 225 230 235 240 Thr Leu Glu Asn Met Gly Ser Arg Lys Ser Ser Phe Pro Gln Lys Glu 245 250 255 Ser Leu Phe Gly Arg Pro Arg Ser Tyr Lys Asn Asp Gln Asn Gly Gln 260 265 270 Leu Ser Leu Ser Lys Thr Ser Ser Arg Lys Gly Lys Asn Lys Ile Phe 275 280 285 Phe Ser Ser Glu Asp Glu Asp Ser Asp Trp Asp Ser Val Ser Asn Asp 290 295 300 Ser Glu Phe Tyr Ala Asp Glu Asp Asp Glu Glu Tyr Asp Asp Tyr Asn 305 310 315 320 Glu Glu Glu Ala Asp Gln Tyr Tyr Arg Arg Gln Trp Asp Lys Leu Leu 325 330 335 Phe Ala Lys Asn Gln Gln Asn Leu Asp Ser Thr Lys Ser Ser Val Ser 340 345 350 Ser Ala Asn Thr Ile Asn Ser Asn Thr Ser His Asp Pro Val Arg Lys 355 360 365 Ser Leu Leu Ser Gly Leu Phe Leu Ser Glu Ala Asn Ser Asn Ser Asn 370 375 380 Asn His Asn Thr Ala His Ser Glu Tyr Ala Ser Lys His Val Ser Pro 385 390 395 400 Thr Pro Gln Ser Ser His Ser Asn Ile Gly Pro Gln Pro Gln Gln Asn 405 410 415 Pro Pro Ser Ala Asn Gly Ile Lys Gln Gln Lys Pro Ser Leu Lys Thr 420 425 430 Ser Asn Val Thr Ala Leu Ala Ser Leu Ser Pro Pro Gln Pro Ser Asn 435 440 445 Asn Glu Arg Leu Ser Met Asp Ile Gln Lys Asp Phe Lys Thr Asp Asn 450 455 460 Glu Ser Asn His Leu Tyr Glu Ser Asn Ala Pro Leu Thr Ala Gln Thr 465 470 475 480 Ile Leu Pro Thr Ala Leu Ser Thr His Met Phe Leu Pro Asn Asn Ile 485 490 495 Page 234 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt His Gln Gln Arg Met Ala Ile Ala Thr Gly Ser Asn Thr Arg His Arg 500 505 510 Phe Ser Arg Arg Gln Ser Met Asp Ile Pro Ser Lys Asn Arg Asn Thr 515 520 525 Gly Phe Leu Lys Thr Arg Met Glu Ile Ser Glu Glu Glu Lys Met Val 530 535 540 Arg Thr Ile Ser Arg Leu Asp Asn Thr Ser Ile Ala Asn Ser Asn Gly 545 550 555 560 Asn Gly Asn Asp Asp Thr Ser Asn Gln Arg Thr Glu Ala Leu Gly Arg 565 570 575 Lys Thr Ser Asn Gly Gly Arg Ile 580 <210> 165 <211> 741 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(741) <400> 165 atg gag agt ata ttt ggt ggg ttt gga gat cta gtt gtt cct agg cca 48 Met Glu Ser Ile Phe Gly Gly Phe Gly Asp Leu Val Val Pro Arg Pro 1 5 10 15 aag gag cat ctc ggt caa aca gac ctt tcc ttc ggt gga aaa tta ttg 96 Lys Glu His Leu Gly Gln Thr Asp Leu Ser Phe Gly Gly Lys Leu Leu 20 25 30 cct gca ttg aaa att tgt gaa gat ggc ggt gaa agt ggt tgt ggc ggt 144 Pro Ala Leu Lys Ile Cys Glu Asp Gly Gly Glu Ser Gly Cys Gly Gly 35 40 45 aaa gtc tgg atc gct ggc gaa ctg ttg tgc gag tac ata ctc gag aaa 192 Lys Val Trp Ile Ala Gly Glu Leu Leu Cys Glu Tyr Ile Leu Glu Lys 50 55 60 tca gtt gac cat ctg cta agt aag acg gtc aat ggt acg aaa caa ttt 240 Ser Val Asp His Leu Leu Ser Lys Thr Val Asn Gly Thr Lys Gln Phe 65 70 75 80 aaa aaa gtc tta gaa ttg ggt agt ggt aca ggt tta gtt gga ttg tgc 288 Lys Lys Val Leu Glu Leu Gly Ser Gly Thr Gly Leu Val Gly Leu Cys 85 90 95 gtg ggg ttg ttg gaa aaa aac aca ttc cac gat ggc act aaa gta tat 336 Val Gly Leu Leu Glu Lys Asn Thr Phe His Asp Gly Thr Lys Val Tyr 100 105 110 gtt acg gac att gac aag ttg ata cca cta ttg aaa aga aat ata gaa 384 Val Thr Asp Ile Asp Lys Leu Ile Pro Leu Leu Lys Arg Asn Ile Glu 115 120 125 Page 235 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ctg gac gaa gtt cag tat gaa gtt ctt gcg agg gaa ctt tgg tgg ggt 432 Leu Asp Glu Val Gln Tyr Glu Val Leu Ala Arg Glu Leu Trp Trp Gly 130 135 140 gag ccg ctg tcg gca gat ttc tca cct caa gaa ggt gct atg caa gca 480 Glu Pro Leu Ser Ala Asp Phe Ser Pro Gln Glu Gly Ala Met Gln Ala 145 150 155 160 aat aac gtt gat cta gtt ttg gca gct gat tgt gtg tat ctc gag gaa 528 Asn Asn Val Asp Leu Val Leu Ala Ala Asp Cys Val Tyr Leu Glu Glu 165 170 175 gct ttt cca tta cta gaa aaa aca cta ctt gat ctc act cac tgc ata 576 Ala Phe Pro Leu Leu Glu Lys Thr Leu Leu Asp Leu Thr His Cys Ile 180 185 190 aac cca cct gta atc ttg atg gct tac aag aag aga aga aaa gct gat 624 Asn Pro Pro Val Ile Leu Met Ala Tyr Lys Lys Arg Arg Lys Ala Asp 195 200 205 aaa cat ttt ttc aac aag att aaa aga aat ttt gac gtt ctt gaa att 672 Lys His Phe Phe Asn Lys Ile Lys Arg Asn Phe Asp Val Leu Glu Ile 210 215 220 aca gat ttt agt aaa ttt gaa cat tat ctt aag gaa aga acc cac ttg 720 Thr Asp Phe Ser Lys Phe Glu His Tyr Leu Lys Glu Arg Thr His Leu 225 230 235 240 ttt cag ctt atc agg aag taa 741 Phe Gln Leu Ile Arg Lys 245 <210> 166 <211> 246 <212> PRT <213> Saccharomyces cerevisiae <400> 166 Met Glu Ser Ile Phe Gly Gly Phe Gly Asp Leu Val Val Pro Arg Pro 1 5 10 15 Lys Glu His Leu Gly Gln Thr Asp Leu Ser Phe Gly Gly Lys Leu Leu 20 25 30 Pro Ala Leu Lys Ile Cys Glu Asp Gly Gly Glu Ser Gly Cys Gly Gly 35 40 45 Lys Val Trp Ile Ala Gly Glu Leu Leu Cys Glu Tyr Ile Leu Glu Lys 50 55 60 Ser Val Asp His Leu Leu Ser Lys Thr Val Asn Gly Thr Lys Gln Phe 65 70 75 80 Lys Lys Val Leu Glu Leu Gly Ser Gly Thr Gly Leu Val Gly Leu Cys 85 90 95 Val Gly Leu Leu Glu Lys Asn Thr Phe His Asp Gly Thr Lys Val Tyr 100 105 110 Page 236 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Thr Asp Ile Asp Lys Leu Ile Pro Leu Leu Lys Arg Asn Ile Glu 115 120 125 Leu Asp Glu Val Gln Tyr Glu Val Leu Ala Arg Glu Leu Trp Trp Gly 130 135 140 Glu Pro Leu Ser Ala Asp Phe Ser Pro Gln Glu Gly Ala Met Gln Ala 145 150 155 160 Asn Asn Val Asp Leu Val Leu Ala Ala Asp Cys Val Tyr Leu Glu Glu 165 170 175 Ala Phe Pro Leu Leu Glu Lys Thr Leu Leu Asp Leu Thr His Cys Ile 180 185 190 Asn Pro Pro Val Ile Leu Met Ala Tyr Lys Lys Arg Arg Lys Ala Asp 195 200 205 Lys His Phe Phe Asn Lys Ile Lys Arg Asn Phe Asp Val Leu Glu Ile 210 215 220 Thr Asp Phe Ser Lys Phe Glu His Tyr Leu Lys Glu Arg Thr His Leu 225 230 235 240 Phe Gln Leu Ile Arg Lys 245 <210> 167 <211> 2022 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2022) <400> 167 atg tca acg cac tca aac gac tac ttt tct gct tct tcc gga atg gtc 48 Met Ser Thr His Ser Asn Asp Tyr Phe Ser Ala Ser Ser Gly Met Val 1 5 10 15 tct gag aca tcg tcc gag gtt tct tcg ata aac tct tca cag cct gta 96 Ser Glu Thr Ser Ser Glu Val Ser Ser Ile Asn Ser Ser Gln Pro Val 20 25 30 tca ttc tct aag gct tct att gct gct ccg gtt cca tgc tct gat cta 144 Ser Phe Ser Lys Ala Ser Ile Ala Ala Pro Val Pro Cys Ser Asp Leu 35 40 45 cac agc acc aag tcg aac gat gca tcg aga aaa ttg tct att agt agg 192 His Ser Thr Lys Ser Asn Asp Ala Ser Arg Lys Leu Ser Ile Ser Arg 50 55 60 acg tta act aat cgg ctc aac gac att aaa aag gct gtc gat gac gac 240 Thr Leu Thr Asn Arg Leu Asn Asp Ile Lys Lys Ala Val Asp Asp Asp 65 70 75 80 Page 237 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aac ttg cag acg gaa gaa aat tcc gca gac gtt aat aaa ata tta gaa 288 Asn Leu Gln Thr Glu Glu Asn Ser Ala Asp Val Asn Lys Ile Leu Glu 85 90 95 tct aga ttt gac gtg gcc gat gcc att agg cta cag cac aat gag tca 336 Ser Arg Phe Asp Val Ala Asp Ala Ile Arg Leu Gln His Asn Glu Ser 100 105 110 gtc cag tca aag tta aac atc cca gtc aca cac acc acg act gca ggc 384 Val Gln Ser Lys Leu Asn Ile Pro Val Thr His Thr Thr Thr Ala Gly 115 120 125 gcc tcg ttg tcg gca cca tct tcc tct gct ttc tct gct tct tct att 432 Ala Ser Leu Ser Ala Pro Ser Ser Ser Ala Phe Ser Ala Ser Ser Ile 130 135 140 caa aat gat act aca gaa cat aaa gct tcc atg gac tcc aaa ctc atg 480 Gln Asn Asp Thr Thr Glu His Lys Ala Ser Met Asp Ser Lys Leu Met 145 150 155 160 agg aat aga cta tat ccg gct tcc acg aaa cac tcc ggt aag gat ctt 528 Arg Asn Arg Leu Tyr Pro Ala Ser Thr Lys His Ser Gly Lys Asp Leu 165 170 175 gag gcc caa gga ata acc gaa ttc gag cct gat gaa ccg act gta aaa 576 Glu Ala Gln Gly Ile Thr Glu Phe Glu Pro Asp Glu Pro Thr Val Lys 180 185 190 aaa gta ttc acc aac aag tct acc ggg cag ctg gaa ctg ccc ccc gac 624 Lys Val Phe Thr Asn Lys Ser Thr Gly Gln Leu Glu Leu Pro Pro Asp 195 200 205 ggt ggt tat ggc tgg gtc gtg aca ttc tgt gtg ttc ttg acc atg ttt 672 Gly Gly Tyr Gly Trp Val Val Thr Phe Cys Val Phe Leu Thr Met Phe 210 215 220 tcc acg tgg ggc tgc aac gca tcc ttc ggt gtc gac ctt gcc tac tac 720 Ser Thr Trp Gly Cys Asn Ala Ser Phe Gly Val Asp Leu Ala Tyr Tyr 225 230 235 240 tta aac cat gat act tac cct ggt gct tcg aag tac gat tat gcc tta 768 Leu Asn His Asp Thr Tyr Pro Gly Ala Ser Lys Tyr Asp Tyr Ala Leu 245 250 255 att gct ggc cta act gtc ttt ctc ggt caa ctc tta tcc ccc ctt gtg 816 Ile Ala Gly Leu Thr Val Phe Leu Gly Gln Leu Leu Ser Pro Leu Val 260 265 270 atg gca ctg atg aga ata att ggt ctg cgg acc acc atg ctt ttt ggt 864 Met Ala Leu Met Arg Ile Ile Gly Leu Arg Thr Thr Met Leu Phe Gly 275 280 285 gat gct gta atg ctt gcc gca tat ctc ttg gcc tcc ttt act acc aag 912 Asp Ala Val Met Leu Ala Ala Tyr Leu Leu Ala Ser Phe Thr Thr Lys 290 295 300 tta tgg caa ttg tat gtc acc caa ggt ttt atg gtc ggt tgt tca ata 960 Leu Trp Gln Leu Tyr Val Thr Gln Gly Phe Met Val Gly Cys Ser Ile 305 310 315 320 tca ctg att ttc gtt cca gca aca acc gtc tta cca gga tgg ttc ttg 1008 Ser Leu Ile Phe Val Pro Ala Thr Thr Val Leu Pro Gly Trp Phe Leu 325 330 335 aaa aaa aga gct gtc gca atg ggt gtc tca tta ttg ggt acc ggt gct 1056 Lys Lys Arg Ala Val Ala Met Gly Val Ser Leu Leu Gly Thr Gly Ala 340 345 350 Page 238 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggt ggt gtc gtt tac ggt ttg gct aca aac aaa atg ctt tct gac ttt 1104 Gly Gly Val Val Tyr Gly Leu Ala Thr Asn Lys Met Leu Ser Asp Phe 355 360 365 gga aat acc cgg tgg tgc ctt cgt atc ata ggc ata tcg tgt agc ata 1152 Gly Asn Thr Arg Trp Cys Leu Arg Ile Ile Gly Ile Ser Cys Ser Ile 370 375 380 agt gtt cta gtt gct att gcg ctc tta aaa gaa aga aac cct aca cct 1200 Ser Val Leu Val Ala Ile Ala Leu Leu Lys Glu Arg Asn Pro Thr Pro 385 390 395 400 gcc ata gga ttg aaa tcg cct cgg gcc atg ttt gaa cag ctc aaa gca 1248 Ala Ile Gly Leu Lys Ser Pro Arg Ala Met Phe Glu Gln Leu Lys Ala 405 410 415 atg ttt tca tta aag gtt ata act aag cca ttt gtg gta ctt att gca 1296 Met Phe Ser Leu Lys Val Ile Thr Lys Pro Phe Val Val Leu Ile Ala 420 425 430 tta tgg ttc atg ttc gca tta ttt gcc tac aat atg atg gtt ttt act 1344 Leu Trp Phe Met Phe Ala Leu Phe Ala Tyr Asn Met Met Val Phe Thr 435 440 445 tta tct tca tac gca atc tcg aaa gga tta tca tcg cac gac gct tcc 1392 Leu Ser Ser Tyr Ala Ile Ser Lys Gly Leu Ser Ser His Asp Ala Ser 450 455 460 aca ttg act gcc att ttg aac ggc tcg caa tcc atc gga aga cct ctg 1440 Thr Leu Thr Ala Ile Leu Asn Gly Ser Gln Ser Ile Gly Arg Pro Leu 465 470 475 480 atg ggt tta gcg gga gat aag ttt ggt agg gca aac gta acg atc gta 1488 Met Gly Leu Ala Gly Asp Lys Phe Gly Arg Ala Asn Val Thr Ile Val 485 490 495 tta acc act ttg tta aca ata tat atg ttt gcg ttc tgg atc ccc gct 1536 Leu Thr Thr Leu Leu Thr Ile Tyr Met Phe Ala Phe Trp Ile Pro Ala 500 505 510 cat acg ttt gtt caa ctc atc ttt ttt tca att cta gtt ggc tca tgc 1584 His Thr Phe Val Gln Leu Ile Phe Phe Ser Ile Leu Val Gly Ser Cys 515 520 525 gtt ggt gtc gcc aac gtc atg aat acc gtt ctg att gcc gat atg gtt 1632 Val Gly Val Ala Asn Val Met Asn Thr Val Leu Ile Ala Asp Met Val 530 535 540 aaa cca gaa gag ttt ttg ccc gct tgg gcc ttc gtc aac tac tgt ggt 1680 Lys Pro Glu Glu Phe Leu Pro Ala Trp Ala Phe Val Asn Tyr Cys Gly 545 550 555 560 gcg cct ttc tta ttg gtt tgt gag gtg att gcc cag gca ttg acg gtg 1728 Ala Pro Phe Leu Leu Val Cys Glu Val Ile Ala Gln Ala Leu Thr Val 565 570 575 gag aaa gat aag agc aat cct tac tta cat gca caa att ttt tgc ggt 1776 Glu Lys Asp Lys Ser Asn Pro Tyr Leu His Ala Gln Ile Phe Cys Gly 580 585 590 tgc tgc ttt att gcc gca cta att tta att tct atc ctt cgt gaa tat 1824 Cys Cys Phe Ile Ala Ala Leu Ile Leu Ile Ser Ile Leu Arg Glu Tyr 595 600 605 tct atc agg atg aaa tta acg gaa aga caa gct atg aca aac gag aag 1872 Ser Ile Arg Met Lys Leu Thr Glu Arg Gln Ala Met Thr Asn Glu Lys 610 615 620 Page 239 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tta aaa gaa tgg aag gca agc gaa tac gat acc gat tct gcc gat gaa 1920 Leu Lys Glu Trp Lys Ala Ser Glu Tyr Asp Thr Asp Ser Ala Asp Glu 625 630 635 640 gat tgg ggt aaa tta aaa gaa aga aag act aaa tat gac ctt ctt tta 1968 Asp Trp Gly Lys Leu Lys Glu Arg Lys Thr Lys Tyr Asp Leu Leu Leu 645 650 655 ggt ccg ggc att aaa aaa tac ttc cta aga atg gta tat cca atg aag 2016 Gly Pro Gly Ile Lys Lys Tyr Phe Leu Arg Met Val Tyr Pro Met Lys 660 665 670 gtc tag 2022 Val <210> 168 <211> 673 <212> PRT <213> Saccharomyces cerevisiae <400> 168 Met Ser Thr His Ser Asn Asp Tyr Phe Ser Ala Ser Ser Gly Met Val 1 5 10 15 Ser Glu Thr Ser Ser Glu Val Ser Ser Ile Asn Ser Ser Gln Pro Val 20 25 30 Ser Phe Ser Lys Ala Ser Ile Ala Ala Pro Val Pro Cys Ser Asp Leu 35 40 45 His Ser Thr Lys Ser Asn Asp Ala Ser Arg Lys Leu Ser Ile Ser Arg 50 55 60 Thr Leu Thr Asn Arg Leu Asn Asp Ile Lys Lys Ala Val Asp Asp Asp 65 70 75 80 Asn Leu Gln Thr Glu Glu Asn Ser Ala Asp Val Asn Lys Ile Leu Glu 85 90 95 Ser Arg Phe Asp Val Ala Asp Ala Ile Arg Leu Gln His Asn Glu Ser 100 105 110 Val Gln Ser Lys Leu Asn Ile Pro Val Thr His Thr Thr Thr Ala Gly 115 120 125 Ala Ser Leu Ser Ala Pro Ser Ser Ser Ala Phe Ser Ala Ser Ser Ile 130 135 140 Gln Asn Asp Thr Thr Glu His Lys Ala Ser Met Asp Ser Lys Leu Met 145 150 155 160 Arg Asn Arg Leu Tyr Pro Ala Ser Thr Lys His Ser Gly Lys Asp Leu 165 170 175 Page 240 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Ala Gln Gly Ile Thr Glu Phe Glu Pro Asp Glu Pro Thr Val Lys 180 185 190 Lys Val Phe Thr Asn Lys Ser Thr Gly Gln Leu Glu Leu Pro Pro Asp 195 200 205 Gly Gly Tyr Gly Trp Val Val Thr Phe Cys Val Phe Leu Thr Met Phe 210 215 220 Ser Thr Trp Gly Cys Asn Ala Ser Phe Gly Val Asp Leu Ala Tyr Tyr 225 230 235 240 Leu Asn His Asp Thr Tyr Pro Gly Ala Ser Lys Tyr Asp Tyr Ala Leu 245 250 255 Ile Ala Gly Leu Thr Val Phe Leu Gly Gln Leu Leu Ser Pro Leu Val 260 265 270 Met Ala Leu Met Arg Ile Ile Gly Leu Arg Thr Thr Met Leu Phe Gly 275 280 285 Asp Ala Val Met Leu Ala Ala Tyr Leu Leu Ala Ser Phe Thr Thr Lys 290 295 300 Leu Trp Gln Leu Tyr Val Thr Gln Gly Phe Met Val Gly Cys Ser Ile 305 310 315 320 Ser Leu Ile Phe Val Pro Ala Thr Thr Val Leu Pro Gly Trp Phe Leu 325 330 335 Lys Lys Arg Ala Val Ala Met Gly Val Ser Leu Leu Gly Thr Gly Ala 340 345 350 Gly Gly Val Val Tyr Gly Leu Ala Thr Asn Lys Met Leu Ser Asp Phe 355 360 365 Gly Asn Thr Arg Trp Cys Leu Arg Ile Ile Gly Ile Ser Cys Ser Ile 370 375 380 Ser Val Leu Val Ala Ile Ala Leu Leu Lys Glu Arg Asn Pro Thr Pro 385 390 395 400 Ala Ile Gly Leu Lys Ser Pro Arg Ala Met Phe Glu Gln Leu Lys Ala 405 410 415 Met Phe Ser Leu Lys Val Ile Thr Lys Pro Phe Val Val Leu Ile Ala 420 425 430 Leu Trp Phe Met Phe Ala Leu Phe Ala Tyr Asn Met Met Val Phe Thr 435 440 445 Page 241 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Ser Ser Tyr Ala Ile Ser Lys Gly Leu Ser Ser His Asp Ala Ser 450 455 460 Thr Leu Thr Ala Ile Leu Asn Gly Ser Gln Ser Ile Gly Arg Pro Leu 465 470 475 480 Met Gly Leu Ala Gly Asp Lys Phe Gly Arg Ala Asn Val Thr Ile Val 485 490 495 Leu Thr Thr Leu Leu Thr Ile Tyr Met Phe Ala Phe Trp Ile Pro Ala 500 505 510 His Thr Phe Val Gln Leu Ile Phe Phe Ser Ile Leu Val Gly Ser Cys 515 520 525 Val Gly Val Ala Asn Val Met Asn Thr Val Leu Ile Ala Asp Met Val 530 535 540 Lys Pro Glu Glu Phe Leu Pro Ala Trp Ala Phe Val Asn Tyr Cys Gly 545 550 555 560 Ala Pro Phe Leu Leu Val Cys Glu Val Ile Ala Gln Ala Leu Thr Val 565 570 575 Glu Lys Asp Lys Ser Asn Pro Tyr Leu His Ala Gln Ile Phe Cys Gly 580 585 590 Cys Cys Phe Ile Ala Ala Leu Ile Leu Ile Ser Ile Leu Arg Glu Tyr 595 600 605 Ser Ile Arg Met Lys Leu Thr Glu Arg Gln Ala Met Thr Asn Glu Lys 610 615 620 Leu Lys Glu Trp Lys Ala Ser Glu Tyr Asp Thr Asp Ser Ala Asp Glu 625 630 635 640 Asp Trp Gly Lys Leu Lys Glu Arg Lys Thr Lys Tyr Asp Leu Leu Leu 645 650 655 Gly Pro Gly Ile Lys Lys Tyr Phe Leu Arg Met Val Tyr Pro Met Lys 660 665 670 Val <210> 169 <211> 1569 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS Page 242 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(1569) <400> 169 atg ttg cta ata aga agg acg ata aat gca ttt ctg gga tgt atc cat 48 Met Leu Leu Ile Arg Arg Thr Ile Asn Ala Phe Leu Gly Cys Ile His 1 5 10 15 tgc aat ctt acg gcg acg tgc atc ctg att gcc ttc gtc ata acc atg 96 Cys Asn Leu Thr Ala Thr Cys Ile Leu Ile Ala Phe Val Ile Thr Met 20 25 30 tat gtg gta ctt gta tct gag cct gca tcc gta gac gga act atg gga 144 Tyr Val Val Leu Val Ser Glu Pro Ala Ser Val Asp Gly Thr Met Gly 35 40 45 aat ttt ctt ccg ttt tcc aag atg gat ctt gcg acg aag agg gac aga 192 Asn Phe Leu Pro Phe Ser Lys Met Asp Leu Ala Thr Lys Arg Asp Arg 50 55 60 ccc ttt tat tcg aat tgt gtg aat act cag gac tat ttg ttg aat cca 240 Pro Phe Tyr Ser Asn Cys Val Asn Thr Gln Asp Tyr Leu Leu Asn Pro 65 70 75 80 tcg tac atc aag cag aat gcc tcg ttt gtc atg cta aca agg aac ggg 288 Ser Tyr Ile Lys Gln Asn Ala Ser Phe Val Met Leu Thr Arg Asn Gly 85 90 95 gag cta gaa gat gtt atc aag act atc aac agt ata gaa gag cat ttc 336 Glu Leu Glu Asp Val Ile Lys Thr Ile Asn Ser Ile Glu Glu His Phe 100 105 110 aat cag tgg ttc cac tat cca tat gtg ttc tta aat gac cag ccg ttt 384 Asn Gln Trp Phe His Tyr Pro Tyr Val Phe Leu Asn Asp Gln Pro Phe 115 120 125 gaa gag gac ttc aaa gca aaa gta cgt gat gtt aca gtg ggc gcg ctg 432 Glu Glu Asp Phe Lys Ala Lys Val Arg Asp Val Thr Val Gly Ala Leu 130 135 140 gtg gaa ttt ggc act atc gat gag ata tct tgg aat ttt ccc agt gac 480 Val Glu Phe Gly Thr Ile Asp Glu Ile Ser Trp Asn Phe Pro Ser Asp 145 150 155 160 gta aag gat acg ttc gag ttc tac aac gca att gag gat caa ggt gat 528 Val Lys Asp Thr Phe Glu Phe Tyr Asn Ala Ile Glu Asp Gln Gly Asp 165 170 175 aga agc ata ctt tac gga aac tta gaa tca tat cat aag atg tgc cgg 576 Arg Ser Ile Leu Tyr Gly Asn Leu Glu Ser Tyr His Lys Met Cys Arg 180 185 190 ttt tat tca gga tta ttt tac aag cac ccg cta gta cag aag tac gaa 624 Phe Tyr Ser Gly Leu Phe Tyr Lys His Pro Leu Val Gln Lys Tyr Glu 195 200 205 tgg tat tgg aga ttg gaa ccc gat gtt gag ttt ttc tgt gat att acc 672 Trp Tyr Trp Arg Leu Glu Pro Asp Val Glu Phe Phe Cys Asp Ile Thr 210 215 220 tac gat ccc ttt ttg gag atg ctc cga act aat aag aaa tat gga ttt 720 Tyr Asp Pro Phe Leu Glu Met Leu Arg Thr Asn Lys Lys Tyr Gly Phe 225 230 235 240 acg atc atc atc ccc gaa ttg tat tgg aca gtc cca aat ttg ttt aga 768 Thr Ile Ile Ile Pro Glu Leu Tyr Trp Thr Val Pro Asn Leu Phe Arg 245 250 255 cac act aaa agc ttt atc agt caa aaa ggc gtt acg ctt ggg tca tta 816 Page 243 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt His Thr Lys Ser Phe Ile Ser Gln Lys Gly Val Thr Leu Gly Ser Leu 260 265 270 tgg aaa cta ttt aca aag gat tac gac att ttt gaa tcc gat gat ccg 864 Trp Lys Leu Phe Thr Lys Asp Tyr Asp Ile Phe Glu Ser Asp Asp Pro 275 280 285 gag tta cgg gac tgg atc aac tat gat ttt cag gcc aag gct aag ata 912 Glu Leu Arg Asp Trp Ile Asn Tyr Asp Phe Gln Ala Lys Ala Lys Ile 290 295 300 tcc gaa aag ata gcc atc gag cag ctt ttg aaa aag ggt gat gat ttc 960 Ser Glu Lys Ile Ala Ile Glu Gln Leu Leu Lys Lys Gly Asp Asp Phe 305 310 315 320 caa cag ata aat gat gac aaa gag gga ata atg aat ttg ata cat aag 1008 Gln Gln Ile Asn Asp Asp Lys Glu Gly Ile Met Asn Leu Ile His Lys 325 330 335 gct cgc tct agg aag cat atc gta gaa gac aaa ttt ttc aat gaa gag 1056 Ala Arg Ser Arg Lys His Ile Val Glu Asp Lys Phe Phe Asn Glu Glu 340 345 350 tac aat cta tgc cat ttc tgg agt aat ttt gag att gcg cgg cta agc 1104 Tyr Asn Leu Cys His Phe Trp Ser Asn Phe Glu Ile Ala Arg Leu Ser 355 360 365 gtg ttc gac aat gac att tac aac agt ttt ttt caa tat ttg gag aaa 1152 Val Phe Asp Asn Asp Ile Tyr Asn Ser Phe Phe Gln Tyr Leu Glu Lys 370 375 380 agt ggt gga ttt tgg aag gaa aga tgg ggg gac gct cct gtt cac tct 1200 Ser Gly Gly Phe Trp Lys Glu Arg Trp Gly Asp Ala Pro Val His Ser 385 390 395 400 att gga ttg tcg cta act ctg gat ttg gac gat gta cac tat ttt aga 1248 Ile Gly Leu Ser Leu Thr Leu Asp Leu Asp Asp Val His Tyr Phe Arg 405 410 415 gac atc gga tat aga cac tcc aca ata cag cat tgt cca cat aat gcc 1296 Asp Ile Gly Tyr Arg His Ser Thr Ile Gln His Cys Pro His Asn Ala 420 425 430 atg ggg aat gag gaa ttc tcc tac tta gcc agt gac tca aaa ttc aaa 1344 Met Gly Asn Glu Glu Phe Ser Tyr Leu Ala Ser Asp Ser Lys Phe Lys 435 440 445 cgt aaa aac gcg gcc tac gac gag gga agg gaa ttt ggg tgt ggc tgc 1392 Arg Lys Asn Ala Ala Tyr Asp Glu Gly Arg Glu Phe Gly Cys Gly Cys 450 455 460 agg tgc aga tgt ccc aag aaa aag cgt gaa att gag gat tcc atg ggt 1440 Arg Cys Arg Cys Pro Lys Lys Lys Arg Glu Ile Glu Asp Ser Met Gly 465 470 475 480 ttc tgc gta aat att tgg gta aat ctg ctt aac caa cag agg gga cac 1488 Phe Cys Val Asn Ile Trp Val Asn Leu Leu Asn Gln Gln Arg Gly His 485 490 495 gaa cgc cac gtc gaa gca ctc aac ggc aat gaa atg gag gag cac ata 1536 Glu Arg His Val Glu Ala Leu Asn Gly Asn Glu Met Glu Glu His Ile 500 505 510 agg gaa gac tat cta aga cag ttc gga aac tag 1569 Arg Glu Asp Tyr Leu Arg Gln Phe Gly Asn 515 520 Page 244 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 170 <211> 522 <212> PRT <213> Saccharomyces cerevisiae <400> 170 Met Leu Leu Ile Arg Arg Thr Ile Asn Ala Phe Leu Gly Cys Ile His 1 5 10 15 Cys Asn Leu Thr Ala Thr Cys Ile Leu Ile Ala Phe Val Ile Thr Met 20 25 30 Tyr Val Val Leu Val Ser Glu Pro Ala Ser Val Asp Gly Thr Met Gly 35 40 45 Asn Phe Leu Pro Phe Ser Lys Met Asp Leu Ala Thr Lys Arg Asp Arg 50 55 60 Pro Phe Tyr Ser Asn Cys Val Asn Thr Gln Asp Tyr Leu Leu Asn Pro 65 70 75 80 Ser Tyr Ile Lys Gln Asn Ala Ser Phe Val Met Leu Thr Arg Asn Gly 85 90 95 Glu Leu Glu Asp Val Ile Lys Thr Ile Asn Ser Ile Glu Glu His Phe 100 105 110 Asn Gln Trp Phe His Tyr Pro Tyr Val Phe Leu Asn Asp Gln Pro Phe 115 120 125 Glu Glu Asp Phe Lys Ala Lys Val Arg Asp Val Thr Val Gly Ala Leu 130 135 140 Val Glu Phe Gly Thr Ile Asp Glu Ile Ser Trp Asn Phe Pro Ser Asp 145 150 155 160 Val Lys Asp Thr Phe Glu Phe Tyr Asn Ala Ile Glu Asp Gln Gly Asp 165 170 175 Arg Ser Ile Leu Tyr Gly Asn Leu Glu Ser Tyr His Lys Met Cys Arg 180 185 190 Phe Tyr Ser Gly Leu Phe Tyr Lys His Pro Leu Val Gln Lys Tyr Glu 195 200 205 Trp Tyr Trp Arg Leu Glu Pro Asp Val Glu Phe Phe Cys Asp Ile Thr 210 215 220 Tyr Asp Pro Phe Leu Glu Met Leu Arg Thr Asn Lys Lys Tyr Gly Phe 225 230 235 240 Thr Ile Ile Ile Pro Glu Leu Tyr Trp Thr Val Pro Asn Leu Phe Arg Page 245 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 245 250 255 His Thr Lys Ser Phe Ile Ser Gln Lys Gly Val Thr Leu Gly Ser Leu 260 265 270 Trp Lys Leu Phe Thr Lys Asp Tyr Asp Ile Phe Glu Ser Asp Asp Pro 275 280 285 Glu Leu Arg Asp Trp Ile Asn Tyr Asp Phe Gln Ala Lys Ala Lys Ile 290 295 300 Ser Glu Lys Ile Ala Ile Glu Gln Leu Leu Lys Lys Gly Asp Asp Phe 305 310 315 320 Gln Gln Ile Asn Asp Asp Lys Glu Gly Ile Met Asn Leu Ile His Lys 325 330 335 Ala Arg Ser Arg Lys His Ile Val Glu Asp Lys Phe Phe Asn Glu Glu 340 345 350 Tyr Asn Leu Cys His Phe Trp Ser Asn Phe Glu Ile Ala Arg Leu Ser 355 360 365 Val Phe Asp Asn Asp Ile Tyr Asn Ser Phe Phe Gln Tyr Leu Glu Lys 370 375 380 Ser Gly Gly Phe Trp Lys Glu Arg Trp Gly Asp Ala Pro Val His Ser 385 390 395 400 Ile Gly Leu Ser Leu Thr Leu Asp Leu Asp Asp Val His Tyr Phe Arg 405 410 415 Asp Ile Gly Tyr Arg His Ser Thr Ile Gln His Cys Pro His Asn Ala 420 425 430 Met Gly Asn Glu Glu Phe Ser Tyr Leu Ala Ser Asp Ser Lys Phe Lys 435 440 445 Arg Lys Asn Ala Ala Tyr Asp Glu Gly Arg Glu Phe Gly Cys Gly Cys 450 455 460 Arg Cys Arg Cys Pro Lys Lys Lys Arg Glu Ile Glu Asp Ser Met Gly 465 470 475 480 Phe Cys Val Asn Ile Trp Val Asn Leu Leu Asn Gln Gln Arg Gly His 485 490 495 Glu Arg His Val Glu Ala Leu Asn Gly Asn Glu Met Glu Glu His Ile 500 505 510 Arg Glu Asp Tyr Leu Arg Gln Phe Gly Asn Page 246 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 515 520 <210> 171 <211> 1506 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1506) <400> 171 atg ctt tta caa gga atg cgt tta tcg caa agg tta cat aag aga cat 48 Met Leu Leu Gln Gly Met Arg Leu Ser Gln Arg Leu His Lys Arg His 1 5 10 15 cta ttt gct tcc aag att tta acg tgg act acg aac cct gct cat ata 96 Leu Phe Ala Ser Lys Ile Leu Thr Trp Thr Thr Asn Pro Ala His Ile 20 25 30 cgc cac cta cat gat ata agg ccg cct gca tca aac ttc aat acg caa 144 Arg His Leu His Asp Ile Arg Pro Pro Ala Ser Asn Phe Asn Thr Gln 35 40 45 gaa tcg gcc ccc ata ccg gag tct cca gca aac tca cca act cga cca 192 Glu Ser Ala Pro Ile Pro Glu Ser Pro Ala Asn Ser Pro Thr Arg Pro 50 55 60 cag atg gca cct aaa ccc aat ttg aaa aaa aaa aat cgt agt tta atg 240 Gln Met Ala Pro Lys Pro Asn Leu Lys Lys Lys Asn Arg Ser Leu Met 65 70 75 80 tat tct att att ggg gtt tcc ata gta ggt tta tat ttt tgg ttt aaa 288 Tyr Ser Ile Ile Gly Val Ser Ile Val Gly Leu Tyr Phe Trp Phe Lys 85 90 95 agt aac tcc agg aaa caa aaa cta cct ctt tcg gcg caa aaa gtc tgg 336 Ser Asn Ser Arg Lys Gln Lys Leu Pro Leu Ser Ala Gln Lys Val Trp 100 105 110 aag gaa gcc ata tgg caa gaa agt gat aaa atg gat ttt aat tac aaa 384 Lys Glu Ala Ile Trp Gln Glu Ser Asp Lys Met Asp Phe Asn Tyr Lys 115 120 125 gaa gcg tta agg cgg tat att gag gcg ttg gat gaa tgc gat cgc tct 432 Glu Ala Leu Arg Arg Tyr Ile Glu Ala Leu Asp Glu Cys Asp Arg Ser 130 135 140 cat gtc gat tta ttg tca gat gat tat acc aga ata gag ctg aaa att 480 His Val Asp Leu Leu Ser Asp Asp Tyr Thr Arg Ile Glu Leu Lys Ile 145 150 155 160 gct gaa atg tat gaa aag ctc aat atg ctt gaa gaa gcc caa aat ttg 528 Ala Glu Met Tyr Glu Lys Leu Asn Met Leu Glu Glu Ala Gln Asn Leu 165 170 175 tac caa gaa tta tta agt cgg ttt ttc gaa gcg ctg aat gtt cct ggc 576 Tyr Gln Glu Leu Leu Ser Arg Phe Phe Glu Ala Leu Asn Val Pro Gly 180 185 190 aaa gtt gat gag agt gaa aga ggc gag gtt tta aga aaa gac ttg aga 624 Lys Val Asp Glu Ser Glu Arg Gly Glu Val Leu Arg Lys Asp Leu Arg 195 200 205 atc ttg att aaa tcg tta gaa atc aat aag gac ata gaa agt ggc aag 672 Ile Leu Ile Lys Ser Leu Glu Ile Asn Lys Asp Ile Glu Ser Gly Lys Page 247 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 210 215 220 aga aaa ttg cta caa cat tta ctt tta gct caa gag gaa att tta agc 720 Arg Lys Leu Leu Gln His Leu Leu Leu Ala Gln Glu Glu Ile Leu Ser 225 230 235 240 aaa tcg cca gag ttg aag gaa ttt ttt gaa aac aga aaa aag aag ctc 768 Lys Ser Pro Glu Leu Lys Glu Phe Phe Glu Asn Arg Lys Lys Lys Leu 245 250 255 tcg atg gta aaa gac atc aat aga gac cct aat gat gat ttt aaa aca 816 Ser Met Val Lys Asp Ile Asn Arg Asp Pro Asn Asp Asp Phe Lys Thr 260 265 270 ttt gtt agt gag gaa aat att aag ttt gat gag caa ggc tat atg att 864 Phe Val Ser Glu Glu Asn Ile Lys Phe Asp Glu Gln Gly Tyr Met Ile 275 280 285 ttg gat ctg gaa aag aat agc agc gct tgg gaa ccc ttt aag gaa gaa 912 Leu Asp Leu Glu Lys Asn Ser Ser Ala Trp Glu Pro Phe Lys Glu Glu 290 295 300 ttt ttt act gcg aga gat tta tat aca gct tat tgt ctg tca tca aaa 960 Phe Phe Thr Ala Arg Asp Leu Tyr Thr Ala Tyr Cys Leu Ser Ser Lys 305 310 315 320 gac ata gct gca gct cta agt tgc aag ata act agt gtg gaa tgg atg 1008 Asp Ile Ala Ala Ala Leu Ser Cys Lys Ile Thr Ser Val Glu Trp Met 325 330 335 gtt atg gca gac atg cca cca gga cag ata ttg cta tca cag gca aat 1056 Val Met Ala Asp Met Pro Pro Gly Gln Ile Leu Leu Ser Gln Ala Asn 340 345 350 ttg ggg tca ttg ttc tat ctt caa gca gaa aag cta gaa gct gac tta 1104 Leu Gly Ser Leu Phe Tyr Leu Gln Ala Glu Lys Leu Glu Ala Asp Leu 355 360 365 aat caa tta gag caa aag aaa agt aaa gag tcc aac caa gag tta gat 1152 Asn Gln Leu Glu Gln Lys Lys Ser Lys Glu Ser Asn Gln Glu Leu Asp 370 375 380 atg gga aca tac ata aaa gcc gtt aga ttc gta cgc aaa aat cgt gac 1200 Met Gly Thr Tyr Ile Lys Ala Val Arg Phe Val Arg Lys Asn Arg Asp 385 390 395 400 tta tgt ctg gaa aga gca caa aaa tgt tac gac agc gtt att gcg ttt 1248 Leu Cys Leu Glu Arg Ala Gln Lys Cys Tyr Asp Ser Val Ile Ala Phe 405 410 415 gcc aaa aga aac aga aaa att agg ttt cat gtg aag gat caa ctg gat 1296 Ala Lys Arg Asn Arg Lys Ile Arg Phe His Val Lys Asp Gln Leu Asp 420 425 430 cct tca att gca cag tca att gct cta tct acc tat gga atg ggg gtt 1344 Pro Ser Ile Ala Gln Ser Ile Ala Leu Ser Thr Tyr Gly Met Gly Val 435 440 445 tta agc ctt cat gaa ggt gtt ttg gct aaa gct gaa aaa cta ttc aaa 1392 Leu Ser Leu His Glu Gly Val Leu Ala Lys Ala Glu Lys Leu Phe Lys 450 455 460 gat tcg atc act atg gcc aag gag act gaa ttt aat gaa ctc ctt gca 1440 Asp Ser Ile Thr Met Ala Lys Glu Thr Glu Phe Asn Glu Leu Leu Ala 465 470 475 480 gaa gct gaa aag gaa cta gaa aag acg aca gtc ttg aaa gcg gcc aaa 1488 Glu Ala Glu Lys Glu Leu Glu Lys Thr Thr Val Leu Lys Ala Ala Lys Page 248 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 485 490 495 aaa gag ggt tta aac taa 1506 Lys Glu Gly Leu Asn 500 <210> 172 <211> 501 <212> PRT <213> Saccharomyces cerevisiae <400> 172 Met Leu Leu Gln Gly Met Arg Leu Ser Gln Arg Leu His Lys Arg His 1 5 10 15 Leu Phe Ala Ser Lys Ile Leu Thr Trp Thr Thr Asn Pro Ala His Ile 20 25 30 Arg His Leu His Asp Ile Arg Pro Pro Ala Ser Asn Phe Asn Thr Gln 35 40 45 Glu Ser Ala Pro Ile Pro Glu Ser Pro Ala Asn Ser Pro Thr Arg Pro 50 55 60 Gln Met Ala Pro Lys Pro Asn Leu Lys Lys Lys Asn Arg Ser Leu Met 65 70 75 80 Tyr Ser Ile Ile Gly Val Ser Ile Val Gly Leu Tyr Phe Trp Phe Lys 85 90 95 Ser Asn Ser Arg Lys Gln Lys Leu Pro Leu Ser Ala Gln Lys Val Trp 100 105 110 Lys Glu Ala Ile Trp Gln Glu Ser Asp Lys Met Asp Phe Asn Tyr Lys 115 120 125 Glu Ala Leu Arg Arg Tyr Ile Glu Ala Leu Asp Glu Cys Asp Arg Ser 130 135 140 His Val Asp Leu Leu Ser Asp Asp Tyr Thr Arg Ile Glu Leu Lys Ile 145 150 155 160 Ala Glu Met Tyr Glu Lys Leu Asn Met Leu Glu Glu Ala Gln Asn Leu 165 170 175 Tyr Gln Glu Leu Leu Ser Arg Phe Phe Glu Ala Leu Asn Val Pro Gly 180 185 190 Lys Val Asp Glu Ser Glu Arg Gly Glu Val Leu Arg Lys Asp Leu Arg 195 200 205 Ile Leu Ile Lys Ser Leu Glu Ile Asn Lys Asp Ile Glu Ser Gly Lys 210 215 220 Page 249 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Lys Leu Leu Gln His Leu Leu Leu Ala Gln Glu Glu Ile Leu Ser 225 230 235 240 Lys Ser Pro Glu Leu Lys Glu Phe Phe Glu Asn Arg Lys Lys Lys Leu 245 250 255 Ser Met Val Lys Asp Ile Asn Arg Asp Pro Asn Asp Asp Phe Lys Thr 260 265 270 Phe Val Ser Glu Glu Asn Ile Lys Phe Asp Glu Gln Gly Tyr Met Ile 275 280 285 Leu Asp Leu Glu Lys Asn Ser Ser Ala Trp Glu Pro Phe Lys Glu Glu 290 295 300 Phe Phe Thr Ala Arg Asp Leu Tyr Thr Ala Tyr Cys Leu Ser Ser Lys 305 310 315 320 Asp Ile Ala Ala Ala Leu Ser Cys Lys Ile Thr Ser Val Glu Trp Met 325 330 335 Val Met Ala Asp Met Pro Pro Gly Gln Ile Leu Leu Ser Gln Ala Asn 340 345 350 Leu Gly Ser Leu Phe Tyr Leu Gln Ala Glu Lys Leu Glu Ala Asp Leu 355 360 365 Asn Gln Leu Glu Gln Lys Lys Ser Lys Glu Ser Asn Gln Glu Leu Asp 370 375 380 Met Gly Thr Tyr Ile Lys Ala Val Arg Phe Val Arg Lys Asn Arg Asp 385 390 395 400 Leu Cys Leu Glu Arg Ala Gln Lys Cys Tyr Asp Ser Val Ile Ala Phe 405 410 415 Ala Lys Arg Asn Arg Lys Ile Arg Phe His Val Lys Asp Gln Leu Asp 420 425 430 Pro Ser Ile Ala Gln Ser Ile Ala Leu Ser Thr Tyr Gly Met Gly Val 435 440 445 Leu Ser Leu His Glu Gly Val Leu Ala Lys Ala Glu Lys Leu Phe Lys 450 455 460 Asp Ser Ile Thr Met Ala Lys Glu Thr Glu Phe Asn Glu Leu Leu Ala 465 470 475 480 Glu Ala Glu Lys Glu Leu Glu Lys Thr Thr Val Leu Lys Ala Ala Lys 485 490 495 Page 250 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Glu Gly Leu Asn 500 <210> 173 <211> 327 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(327) <400> 173 atg tcc att gag aat ctg aaa tca ttt gat cct ttc gcc gac aca gga 48 Met Ser Ile Glu Asn Leu Lys Ser Phe Asp Pro Phe Ala Asp Thr Gly 1 5 10 15 gac gac gaa acc gcc act tca aac tat att cat att cgt atc caa cag 96 Asp Asp Glu Thr Ala Thr Ser Asn Tyr Ile His Ile Arg Ile Gln Gln 20 25 30 aga aat ggt aga aaa act tta act acg gtg caa ggt gtc cca gag gaa 144 Arg Asn Gly Arg Lys Thr Leu Thr Thr Val Gln Gly Val Pro Glu Glu 35 40 45 tat gat tta aag aga att ctt aag gtc cta aag aag gac ttt gca tgt 192 Tyr Asp Leu Lys Arg Ile Leu Lys Val Leu Lys Lys Asp Phe Ala Cys 50 55 60 aat ggt aac att gtc aag gat cca gaa atg ggg gag att att cag ttg 240 Asn Gly Asn Ile Val Lys Asp Pro Glu Met Gly Glu Ile Ile Gln Leu 65 70 75 80 cag ggt gac caa aga gca aag gtt tgc gaa ttt atg atc tcc caa ctg 288 Gln Gly Asp Gln Arg Ala Lys Val Cys Glu Phe Met Ile Ser Gln Leu 85 90 95 gga ttg caa aag aag aac att aaa att cat ggg ttt taa 327 Gly Leu Gln Lys Lys Asn Ile Lys Ile His Gly Phe 100 105 <210> 174 <211> 108 <212> PRT <213> Saccharomyces cerevisiae <400> 174 Met Ser Ile Glu Asn Leu Lys Ser Phe Asp Pro Phe Ala Asp Thr Gly 1 5 10 15 Asp Asp Glu Thr Ala Thr Ser Asn Tyr Ile His Ile Arg Ile Gln Gln 20 25 30 Arg Asn Gly Arg Lys Thr Leu Thr Thr Val Gln Gly Val Pro Glu Glu 35 40 45 Tyr Asp Leu Lys Arg Ile Leu Lys Val Leu Lys Lys Asp Phe Ala Cys 50 55 60 Page 251 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Gly Asn Ile Val Lys Asp Pro Glu Met Gly Glu Ile Ile Gln Leu 65 70 75 80 Gln Gly Asp Gln Arg Ala Lys Val Cys Glu Phe Met Ile Ser Gln Leu 85 90 95 Gly Leu Gln Lys Lys Asn Ile Lys Ile His Gly Phe 100 105 <210> 175 <211> 669 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(669) <400> 175 atg acc gtc gtt atc gga gtc ttg gca tta cag ggt gcg ttc att gaa 48 Met Thr Val Val Ile Gly Val Leu Ala Leu Gln Gly Ala Phe Ile Glu 1 5 10 15 cat gtg cga cac gta gaa aaa tgc atc gtc gaa aac agg gat ttc tat 96 His Val Arg His Val Glu Lys Cys Ile Val Glu Asn Arg Asp Phe Tyr 20 25 30 gaa aaa aaa cta tct gtg atg aca gtg aag gat aaa aat caa cta gct 144 Glu Lys Lys Leu Ser Val Met Thr Val Lys Asp Lys Asn Gln Leu Ala 35 40 45 caa tgt gat gca ttg atc ata cct ggg gga gag tcg act gca atg tcc 192 Gln Cys Asp Ala Leu Ile Ile Pro Gly Gly Glu Ser Thr Ala Met Ser 50 55 60 ctt att gca gaa aga aca gga ttt tac gac gat ctc tac gca ttc gta 240 Leu Ile Ala Glu Arg Thr Gly Phe Tyr Asp Asp Leu Tyr Ala Phe Val 65 70 75 80 cac aac cca agc aag gta acc tgg ggt act tgt gca ggt atg att tat 288 His Asn Pro Ser Lys Val Thr Trp Gly Thr Cys Ala Gly Met Ile Tyr 85 90 95 att tca caa caa tta tct aac gaa gaa aaa ctg gtc aag acg ctg aat 336 Ile Ser Gln Gln Leu Ser Asn Glu Glu Lys Leu Val Lys Thr Leu Asn 100 105 110 tta cta aag gtt aaa gta aaa aga aat gca ttt ggg aga caa gct cag 384 Leu Leu Lys Val Lys Val Lys Arg Asn Ala Phe Gly Arg Gln Ala Gln 115 120 125 tct tct acc cgg att tgc gac ttt tca aac ttt att cct cac tgc aat 432 Ser Ser Thr Arg Ile Cys Asp Phe Ser Asn Phe Ile Pro His Cys Asn 130 135 140 gat ttt cct gct act ttt ata aga gcc cca gta ata gaa gag gtg ctg 480 Asp Phe Pro Ala Thr Phe Ile Arg Ala Pro Val Ile Glu Glu Val Leu 145 150 155 160 gat cct gaa cat gtg cag gtc ctg tac aaa tta gat ggg aag gat aat 528 Asp Pro Glu His Val Gln Val Leu Tyr Lys Leu Asp Gly Lys Asp Asn 165 170 175 Page 252 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggt ggt caa gaa cta att gtt gcc gct aag caa aaa aac aat att ctt 576 Gly Gly Gln Glu Leu Ile Val Ala Ala Lys Gln Lys Asn Asn Ile Leu 180 185 190 gcg aca tca ttt cat ccg gaa ttg gca gaa aac gat ata cgg ttt cac 624 Ala Thr Ser Phe His Pro Glu Leu Ala Glu Asn Asp Ile Arg Phe His 195 200 205 gac tgg ttc atc aga gaa ttt gtt ctt aaa aac tac agt aaa taa 669 Asp Trp Phe Ile Arg Glu Phe Val Leu Lys Asn Tyr Ser Lys 210 215 220 <210> 176 <211> 222 <212> PRT <213> Saccharomyces cerevisiae <400> 176 Met Thr Val Val Ile Gly Val Leu Ala Leu Gln Gly Ala Phe Ile Glu 1 5 10 15 His Val Arg His Val Glu Lys Cys Ile Val Glu Asn Arg Asp Phe Tyr 20 25 30 Glu Lys Lys Leu Ser Val Met Thr Val Lys Asp Lys Asn Gln Leu Ala 35 40 45 Gln Cys Asp Ala Leu Ile Ile Pro Gly Gly Glu Ser Thr Ala Met Ser 50 55 60 Leu Ile Ala Glu Arg Thr Gly Phe Tyr Asp Asp Leu Tyr Ala Phe Val 65 70 75 80 His Asn Pro Ser Lys Val Thr Trp Gly Thr Cys Ala Gly Met Ile Tyr 85 90 95 Ile Ser Gln Gln Leu Ser Asn Glu Glu Lys Leu Val Lys Thr Leu Asn 100 105 110 Leu Leu Lys Val Lys Val Lys Arg Asn Ala Phe Gly Arg Gln Ala Gln 115 120 125 Ser Ser Thr Arg Ile Cys Asp Phe Ser Asn Phe Ile Pro His Cys Asn 130 135 140 Asp Phe Pro Ala Thr Phe Ile Arg Ala Pro Val Ile Glu Glu Val Leu 145 150 155 160 Asp Pro Glu His Val Gln Val Leu Tyr Lys Leu Asp Gly Lys Asp Asn 165 170 175 Gly Gly Gln Glu Leu Ile Val Ala Ala Lys Gln Lys Asn Asn Ile Leu 180 185 190 Page 253 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Thr Ser Phe His Pro Glu Leu Ala Glu Asn Asp Ile Arg Phe His 195 200 205 Asp Trp Phe Ile Arg Glu Phe Val Leu Lys Asn Tyr Ser Lys 210 215 220 <210> 177 <211> 675 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(675) <400> 177 atg aag att tta acc caa gac gaa att gaa gct cat cgc tca cat acg 48 Met Lys Ile Leu Thr Gln Asp Glu Ile Glu Ala His Arg Ser His Thr 1 5 10 15 cta aaa ggt ggt att gaa ggt gcc ctt gcc gga ttt gca atc tct gct 96 Leu Lys Gly Gly Ile Glu Gly Ala Leu Ala Gly Phe Ala Ile Ser Ala 20 25 30 ata att ttc aaa gtc cta cca aga agg tac cca aaa ttc aag cct tcg 144 Ile Ile Phe Lys Val Leu Pro Arg Arg Tyr Pro Lys Phe Lys Pro Ser 35 40 45 act cta aca tgg tcc ata aaa acc gcc ctt tgg atc acc cct ccc acg 192 Thr Leu Thr Trp Ser Ile Lys Thr Ala Leu Trp Ile Thr Pro Pro Thr 50 55 60 gtc ttg act gct ata tgt gcg gag gag gcc tcg aac aat ttc gac gct 240 Val Leu Thr Ala Ile Cys Ala Glu Glu Ala Ser Asn Asn Phe Asp Ala 65 70 75 80 aca atg tac gga tcc ggt tcc tcc tcg gaa gac gca cta gat gag cac 288 Thr Met Tyr Gly Ser Gly Ser Ser Ser Glu Asp Ala Leu Asp Glu His 85 90 95 aga aga tgg aag agt ttg agt aca aag gac aag ttt gtc gaa ggt cta 336 Arg Arg Trp Lys Ser Leu Ser Thr Lys Asp Lys Phe Val Glu Gly Leu 100 105 110 tct aat aac aag tat aag atc atc acc ggt gcc tgg gcc gct tcg ctg 384 Ser Asn Asn Lys Tyr Lys Ile Ile Thr Gly Ala Trp Ala Ala Ser Leu 115 120 125 tat ggg tcg tgg gta atc gtg aac aaa gac ccc atc atg acc aaa gct 432 Tyr Gly Ser Trp Val Ile Val Asn Lys Asp Pro Ile Met Thr Lys Ala 130 135 140 cag aag atc gtg cag gca aga atg tac gct caa ttc att acc gtc ggg 480 Gln Lys Ile Val Gln Ala Arg Met Tyr Ala Gln Phe Ile Thr Val Gly 145 150 155 160 ctg ctg ctg gcc tcc gtt ggt ttg agc atg tac gag aat aag tta cat 528 Leu Leu Leu Ala Ser Val Gly Leu Ser Met Tyr Glu Asn Lys Leu His 165 170 175 cct aac aaa caa aag gtc aac gaa atg cgc cgc tgg gaa aac gca ctg 576 Pro Asn Lys Gln Lys Val Asn Glu Met Arg Arg Trp Glu Asn Ala Leu 180 185 190 agg gtc gcc gaa gag gaa gag aga ctc gag aaa gag gga aga agg acc 624 Page 254 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Val Ala Glu Glu Glu Glu Arg Leu Glu Lys Glu Gly Arg Arg Thr 195 200 205 ggc tac gtt tct aac gaa gaa aga ata aac tcc aag atc ttc aag tcg 672 Gly Tyr Val Ser Asn Glu Glu Arg Ile Asn Ser Lys Ile Phe Lys Ser 210 215 220 taa 675 <210> 178 <211> 224 <212> PRT <213> Saccharomyces cerevisiae <400> 178 Met Lys Ile Leu Thr Gln Asp Glu Ile Glu Ala His Arg Ser His Thr 1 5 10 15 Leu Lys Gly Gly Ile Glu Gly Ala Leu Ala Gly Phe Ala Ile Ser Ala 20 25 30 Ile Ile Phe Lys Val Leu Pro Arg Arg Tyr Pro Lys Phe Lys Pro Ser 35 40 45 Thr Leu Thr Trp Ser Ile Lys Thr Ala Leu Trp Ile Thr Pro Pro Thr 50 55 60 Val Leu Thr Ala Ile Cys Ala Glu Glu Ala Ser Asn Asn Phe Asp Ala 65 70 75 80 Thr Met Tyr Gly Ser Gly Ser Ser Ser Glu Asp Ala Leu Asp Glu His 85 90 95 Arg Arg Trp Lys Ser Leu Ser Thr Lys Asp Lys Phe Val Glu Gly Leu 100 105 110 Ser Asn Asn Lys Tyr Lys Ile Ile Thr Gly Ala Trp Ala Ala Ser Leu 115 120 125 Tyr Gly Ser Trp Val Ile Val Asn Lys Asp Pro Ile Met Thr Lys Ala 130 135 140 Gln Lys Ile Val Gln Ala Arg Met Tyr Ala Gln Phe Ile Thr Val Gly 145 150 155 160 Leu Leu Leu Ala Ser Val Gly Leu Ser Met Tyr Glu Asn Lys Leu His 165 170 175 Pro Asn Lys Gln Lys Val Asn Glu Met Arg Arg Trp Glu Asn Ala Leu 180 185 190 Arg Val Ala Glu Glu Glu Glu Arg Leu Glu Lys Glu Gly Arg Arg Thr 195 200 205 Page 255 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Tyr Val Ser Asn Glu Glu Arg Ile Asn Ser Lys Ile Phe Lys Ser 210 215 220 <210> 179 <211> 1461 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1461) <400> 179 atg tcg cat act tta aaa tcg aaa acg ctc caa gag ctg gac att gag 48 Met Ser His Thr Leu Lys Ser Lys Thr Leu Gln Glu Leu Asp Ile Glu 1 5 10 15 gag att aag gaa act aac cca ttg ctc aaa cta gtt caa ggg cag agg 96 Glu Ile Lys Glu Thr Asn Pro Leu Leu Lys Leu Val Gln Gly Gln Arg 20 25 30 att gtt caa gtt ccg gaa cta gtg ctt gag tct ggc gtg gtc ata aat 144 Ile Val Gln Val Pro Glu Leu Val Leu Glu Ser Gly Val Val Ile Asn 35 40 45 aat ttc cct att gct tat aag acg tgg ggt aca ctg aat gaa gct ggt 192 Asn Phe Pro Ile Ala Tyr Lys Thr Trp Gly Thr Leu Asn Glu Ala Gly 50 55 60 gat aat gtt ctg gta att tgt cat gcc ttg act ggg tcc gca gat gtt 240 Asp Asn Val Leu Val Ile Cys His Ala Leu Thr Gly Ser Ala Asp Val 65 70 75 80 gct gac tgg tgg ggc cct ctt ctg ggt aac gac tta gca ttc gac cca 288 Ala Asp Trp Trp Gly Pro Leu Leu Gly Asn Asp Leu Ala Phe Asp Pro 85 90 95 tca agg ttt ttt atc ata tgt tta aac tct atg ggc tct cca tat ggg 336 Ser Arg Phe Phe Ile Ile Cys Leu Asn Ser Met Gly Ser Pro Tyr Gly 100 105 110 tct ttt tcg cca tta acg ata aat gag gag acg ggc gtt aga tat gga 384 Ser Phe Ser Pro Leu Thr Ile Asn Glu Glu Thr Gly Val Arg Tyr Gly 115 120 125 ccc gaa ttc cca tta tgt act gtg cgc gat gac gtt aga gct cac aga 432 Pro Glu Phe Pro Leu Cys Thr Val Arg Asp Asp Val Arg Ala His Arg 130 135 140 att gtt ctg gat tct ctg gga gta aag tca ata gcc tgt gtt att ggt 480 Ile Val Leu Asp Ser Leu Gly Val Lys Ser Ile Ala Cys Val Ile Gly 145 150 155 160 ggc tct atg ggg ggg atg ctg agt ttg gaa tgg gct gcc atg tat ggt 528 Gly Ser Met Gly Gly Met Leu Ser Leu Glu Trp Ala Ala Met Tyr Gly 165 170 175 aag gaa tat gtg aag aat atg gtt gct ctg gcg aca tca gca aga cat 576 Lys Glu Tyr Val Lys Asn Met Val Ala Leu Ala Thr Ser Ala Arg His 180 185 190 tct gcc tgg tgc ata tcg tgg tct gag gct caa aga caa tcg att tac 624 Ser Ala Trp Cys Ile Ser Trp Ser Glu Ala Gln Arg Gln Ser Ile Tyr 195 200 205 Page 256 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tca gat ccc aac tac ttg gac ggg tac tat ccg gta gag gag caa cct 672 Ser Asp Pro Asn Tyr Leu Asp Gly Tyr Tyr Pro Val Glu Glu Gln Pro 210 215 220 gtg gcc gga cta tcg gct gca cgt atg tct gca ttg ttg acg tac agg 720 Val Ala Gly Leu Ser Ala Ala Arg Met Ser Ala Leu Leu Thr Tyr Arg 225 230 235 240 aca aga aac agt ttc gag aac aaa ttc tcc aga aga tct cct tca ata 768 Thr Arg Asn Ser Phe Glu Asn Lys Phe Ser Arg Arg Ser Pro Ser Ile 245 250 255 gca caa caa caa aaa gct caa agg gag gag aca cgc aaa cca tct act 816 Ala Gln Gln Gln Lys Ala Gln Arg Glu Glu Thr Arg Lys Pro Ser Thr 260 265 270 gtc agc gaa cac tcc cta caa atc cac aat gat ggg tat aaa aca aaa 864 Val Ser Glu His Ser Leu Gln Ile His Asn Asp Gly Tyr Lys Thr Lys 275 280 285 gcc agc act gcc atc gct ggc att tct ggg caa aaa ggt caa agc gtg 912 Ala Ser Thr Ala Ile Ala Gly Ile Ser Gly Gln Lys Gly Gln Ser Val 290 295 300 gtg tcc acc gca tct tct tcg gat tca ttg aat tct tca aca tcg atg 960 Val Ser Thr Ala Ser Ser Ser Asp Ser Leu Asn Ser Ser Thr Ser Met 305 310 315 320 act tcg gta agt tct gta acg ggt gaa gtg aag gac ata aag cct gcg 1008 Thr Ser Val Ser Ser Val Thr Gly Glu Val Lys Asp Ile Lys Pro Ala 325 330 335 cag acg tat ttt tct gca caa agt tac ttg agg tac cag ggc aca aag 1056 Gln Thr Tyr Phe Ser Ala Gln Ser Tyr Leu Arg Tyr Gln Gly Thr Lys 340 345 350 ttc atc aat agg ttc gac gcc aat tgt tac att gcc atc aca cgt aaa 1104 Phe Ile Asn Arg Phe Asp Ala Asn Cys Tyr Ile Ala Ile Thr Arg Lys 355 360 365 ctg gat acg cac gat ttg gca aga gac aga gta gat gac atc act gag 1152 Leu Asp Thr His Asp Leu Ala Arg Asp Arg Val Asp Asp Ile Thr Glu 370 375 380 gtc ctt tct acc atc caa caa cca tcc ctg atc atc ggt atc caa tct 1200 Val Leu Ser Thr Ile Gln Gln Pro Ser Leu Ile Ile Gly Ile Gln Ser 385 390 395 400 gat gga ctg ttc aca tat tca gaa caa gaa ttt ttg gct gag cac ata 1248 Asp Gly Leu Phe Thr Tyr Ser Glu Gln Glu Phe Leu Ala Glu His Ile 405 410 415 ccg aag tcg caa tta gaa aaa att gaa tct ccc gaa ggc cac gat gcc 1296 Pro Lys Ser Gln Leu Glu Lys Ile Glu Ser Pro Glu Gly His Asp Ala 420 425 430 ttc cta ttg gag ttt aag ctg ata aac aaa ctg ata gta caa ttt tta 1344 Phe Leu Leu Glu Phe Lys Leu Ile Asn Lys Leu Ile Val Gln Phe Leu 435 440 445 aaa acc aac tgc aag gcc att acc gat gcc gct cca aga gct tgg gga 1392 Lys Thr Asn Cys Lys Ala Ile Thr Asp Ala Ala Pro Arg Ala Trp Gly 450 455 460 ggt gac gtt ggt aac gat gaa acg aag acg tct gtc ttt ggt gag gcc 1440 Gly Asp Val Gly Asn Asp Glu Thr Lys Thr Ser Val Phe Gly Glu Ala 465 470 475 480 Page 257 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa gaa gtt acc aac tgg tag 1461 Glu Glu Val Thr Asn Trp 485 <210> 180 <211> 486 <212> PRT <213> Saccharomyces cerevisiae <400> 180 Met Ser His Thr Leu Lys Ser Lys Thr Leu Gln Glu Leu Asp Ile Glu 1 5 10 15 Glu Ile Lys Glu Thr Asn Pro Leu Leu Lys Leu Val Gln Gly Gln Arg 20 25 30 Ile Val Gln Val Pro Glu Leu Val Leu Glu Ser Gly Val Val Ile Asn 35 40 45 Asn Phe Pro Ile Ala Tyr Lys Thr Trp Gly Thr Leu Asn Glu Ala Gly 50 55 60 Asp Asn Val Leu Val Ile Cys His Ala Leu Thr Gly Ser Ala Asp Val 65 70 75 80 Ala Asp Trp Trp Gly Pro Leu Leu Gly Asn Asp Leu Ala Phe Asp Pro 85 90 95 Ser Arg Phe Phe Ile Ile Cys Leu Asn Ser Met Gly Ser Pro Tyr Gly 100 105 110 Ser Phe Ser Pro Leu Thr Ile Asn Glu Glu Thr Gly Val Arg Tyr Gly 115 120 125 Pro Glu Phe Pro Leu Cys Thr Val Arg Asp Asp Val Arg Ala His Arg 130 135 140 Ile Val Leu Asp Ser Leu Gly Val Lys Ser Ile Ala Cys Val Ile Gly 145 150 155 160 Gly Ser Met Gly Gly Met Leu Ser Leu Glu Trp Ala Ala Met Tyr Gly 165 170 175 Lys Glu Tyr Val Lys Asn Met Val Ala Leu Ala Thr Ser Ala Arg His 180 185 190 Ser Ala Trp Cys Ile Ser Trp Ser Glu Ala Gln Arg Gln Ser Ile Tyr 195 200 205 Ser Asp Pro Asn Tyr Leu Asp Gly Tyr Tyr Pro Val Glu Glu Gln Pro 210 215 220 Page 258 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Ala Gly Leu Ser Ala Ala Arg Met Ser Ala Leu Leu Thr Tyr Arg 225 230 235 240 Thr Arg Asn Ser Phe Glu Asn Lys Phe Ser Arg Arg Ser Pro Ser Ile 245 250 255 Ala Gln Gln Gln Lys Ala Gln Arg Glu Glu Thr Arg Lys Pro Ser Thr 260 265 270 Val Ser Glu His Ser Leu Gln Ile His Asn Asp Gly Tyr Lys Thr Lys 275 280 285 Ala Ser Thr Ala Ile Ala Gly Ile Ser Gly Gln Lys Gly Gln Ser Val 290 295 300 Val Ser Thr Ala Ser Ser Ser Asp Ser Leu Asn Ser Ser Thr Ser Met 305 310 315 320 Thr Ser Val Ser Ser Val Thr Gly Glu Val Lys Asp Ile Lys Pro Ala 325 330 335 Gln Thr Tyr Phe Ser Ala Gln Ser Tyr Leu Arg Tyr Gln Gly Thr Lys 340 345 350 Phe Ile Asn Arg Phe Asp Ala Asn Cys Tyr Ile Ala Ile Thr Arg Lys 355 360 365 Leu Asp Thr His Asp Leu Ala Arg Asp Arg Val Asp Asp Ile Thr Glu 370 375 380 Val Leu Ser Thr Ile Gln Gln Pro Ser Leu Ile Ile Gly Ile Gln Ser 385 390 395 400 Asp Gly Leu Phe Thr Tyr Ser Glu Gln Glu Phe Leu Ala Glu His Ile 405 410 415 Pro Lys Ser Gln Leu Glu Lys Ile Glu Ser Pro Glu Gly His Asp Ala 420 425 430 Phe Leu Leu Glu Phe Lys Leu Ile Asn Lys Leu Ile Val Gln Phe Leu 435 440 445 Lys Thr Asn Cys Lys Ala Ile Thr Asp Ala Ala Pro Arg Ala Trp Gly 450 455 460 Gly Asp Val Gly Asn Asp Glu Thr Lys Thr Ser Val Phe Gly Glu Ala 465 470 475 480 Glu Glu Val Thr Asn Trp 485 Page 259 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 181 <211> 309 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(309) <400> 181 atg tct ttt aga aag aaa aaa ctc aaa cct cca gcg ggt agt caa ttt 48 Met Ser Phe Arg Lys Lys Lys Leu Lys Pro Pro Ala Gly Ser Gln Phe 1 5 10 15 att ata aac gac tcc ata atg agc tat att gac cgc acg aaa aca cta 96 Ile Ile Asn Asp Ser Ile Met Ser Tyr Ile Asp Arg Thr Lys Thr Leu 20 25 30 ata agg atg att gga tgc aag aac cag tac ata aaa gca cgt atg aaa 144 Ile Arg Met Ile Gly Cys Lys Asn Gln Tyr Ile Lys Ala Arg Met Lys 35 40 45 gat aag acc ttc ttc tat acg aag caa ttc cgt aca gcc aaa aac aaa 192 Asp Lys Thr Phe Phe Tyr Thr Lys Gln Phe Arg Thr Ala Lys Asn Lys 50 55 60 ttt ttc ttt cat ctg tac cat tgg gag gcc act cat att aac gtt gac 240 Phe Phe Phe His Leu Tyr His Trp Glu Ala Thr His Ile Asn Val Asp 65 70 75 80 cac tat ata tgt aca tgt cat ccc att ttt tgg ggc tct ata ggt cag 288 His Tyr Ile Cys Thr Cys His Pro Ile Phe Trp Gly Ser Ile Gly Gln 85 90 95 aaa ctc agg aga tcc gcc tga 309 Lys Leu Arg Arg Ser Ala 100 <210> 182 <211> 102 <212> PRT <213> Saccharomyces cerevisiae <400> 182 Met Ser Phe Arg Lys Lys Lys Leu Lys Pro Pro Ala Gly Ser Gln Phe 1 5 10 15 Ile Ile Asn Asp Ser Ile Met Ser Tyr Ile Asp Arg Thr Lys Thr Leu 20 25 30 Ile Arg Met Ile Gly Cys Lys Asn Gln Tyr Ile Lys Ala Arg Met Lys 35 40 45 Asp Lys Thr Phe Phe Tyr Thr Lys Gln Phe Arg Thr Ala Lys Asn Lys 50 55 60 Phe Phe Phe His Leu Tyr His Trp Glu Ala Thr His Ile Asn Val Asp 65 70 75 80 His Tyr Ile Cys Thr Cys His Pro Ile Phe Trp Gly Ser Ile Gly Gln Page 260 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Lys Leu Arg Arg Ser Ala 100 <210> 183 <211> 1605 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1605) <400> 183 atg agc tct gac gaa gaa gat ttc aac gac atc tac ggc gat gat aag 48 Met Ser Ser Asp Glu Glu Asp Phe Asn Asp Ile Tyr Gly Asp Asp Lys 1 5 10 15 cct acc act act gaa gaa gtc aaa aaa gaa gaa gaa caa aat aag gct 96 Pro Thr Thr Thr Glu Glu Val Lys Lys Glu Glu Glu Gln Asn Lys Ala 20 25 30 ggc agt ggt acc tcg caa tta gat caa cta gcc gca cta caa gca tta 144 Gly Ser Gly Thr Ser Gln Leu Asp Gln Leu Ala Ala Leu Gln Ala Leu 35 40 45 tct tct agc ttg aac aaa cta aat aat cca aat agt aac aac agt agt 192 Ser Ser Ser Leu Asn Lys Leu Asn Asn Pro Asn Ser Asn Asn Ser Ser 50 55 60 agt aat aat agt aac caa gac aca tct tct agt aag caa gat ggc act 240 Ser Asn Asn Ser Asn Gln Asp Thr Ser Ser Ser Lys Gln Asp Gly Thr 65 70 75 80 gcg aat gac aag gaa ggt tcc aat gaa gac act aag aat gaa aaa aaa 288 Ala Asn Asp Lys Glu Gly Ser Asn Glu Asp Thr Lys Asn Glu Lys Lys 85 90 95 caa gaa agc gct aca tca gca aat gcc aat gcc aac gct agt tct gca 336 Gln Glu Ser Ala Thr Ser Ala Asn Ala Asn Ala Asn Ala Ser Ser Ala 100 105 110 gga cct tct ggc tta cct tgg gaa caa ctt caa caa acc atg tca caa 384 Gly Pro Ser Gly Leu Pro Trp Glu Gln Leu Gln Gln Thr Met Ser Gln 115 120 125 ttc cag caa cca tct tct caa tca cca cct caa cag caa gta act caa 432 Phe Gln Gln Pro Ser Ser Gln Ser Pro Pro Gln Gln Gln Val Thr Gln 130 135 140 acc aaa gag gaa cgt tcg aaa gcg gat ttg tct aaa gaa agt tgc aag 480 Thr Lys Glu Glu Arg Ser Lys Ala Asp Leu Ser Lys Glu Ser Cys Lys 145 150 155 160 atg ttc att ggt ggt ctg aat tgg gac act acg gaa gat aat ctt cgc 528 Met Phe Ile Gly Gly Leu Asn Trp Asp Thr Thr Glu Asp Asn Leu Arg 165 170 175 gaa tat ttt ggt aag tat ggt acc gtc act gat ttg aaa atc atg aaa 576 Glu Tyr Phe Gly Lys Tyr Gly Thr Val Thr Asp Leu Lys Ile Met Lys 180 185 190 gac cct gca aca ggt aga tct aga ggg ttc ggt ttc tta tct ttt gaa 624 Asp Pro Ala Thr Gly Arg Ser Arg Gly Phe Gly Phe Leu Ser Phe Glu Page 261 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 195 200 205 aaa cct tct agt gtt gat gaa gtg gta aag aca caa cat atc ctc gat 672 Lys Pro Ser Ser Val Asp Glu Val Val Lys Thr Gln His Ile Leu Asp 210 215 220 ggt aaa gtt atc gac cca aaa aga gct atc cca aga gac gag caa gat 720 Gly Lys Val Ile Asp Pro Lys Arg Ala Ile Pro Arg Asp Glu Gln Asp 225 230 235 240 aaa acc ggt aaa atc ttt gtt ggt ggt att ggt cct gat gtg aga cca 768 Lys Thr Gly Lys Ile Phe Val Gly Gly Ile Gly Pro Asp Val Arg Pro 245 250 255 aag gaa ttt gaa gaa ttt ttt tct cag tgg ggt acg att atc gat gcg 816 Lys Glu Phe Glu Glu Phe Phe Ser Gln Trp Gly Thr Ile Ile Asp Ala 260 265 270 caa ctg atg tta gat aag gat acc ggt caa tca aga ggt ttt ggt ttt 864 Gln Leu Met Leu Asp Lys Asp Thr Gly Gln Ser Arg Gly Phe Gly Phe 275 280 285 gtg acg tat gac tcc gct gac gcc gtt gac aga gtt tgt cag aat aaa 912 Val Thr Tyr Asp Ser Ala Asp Ala Val Asp Arg Val Cys Gln Asn Lys 290 295 300 ttc atc gat ttc aaa gat cgc aag atc gaa atc aag aga gct gag cca 960 Phe Ile Asp Phe Lys Asp Arg Lys Ile Glu Ile Lys Arg Ala Glu Pro 305 310 315 320 aga cat atg caa caa aaa tca tca aac aat ggt ggt aac aat ggt gga 1008 Arg His Met Gln Gln Lys Ser Ser Asn Asn Gly Gly Asn Asn Gly Gly 325 330 335 aac aac atg aat cgt cgt ggc ggt aac ttc ggt aac caa ggc gat ttc 1056 Asn Asn Met Asn Arg Arg Gly Gly Asn Phe Gly Asn Gln Gly Asp Phe 340 345 350 aac caa atg tat caa aac cct atg atg ggc ggt tac aac cca atg atg 1104 Asn Gln Met Tyr Gln Asn Pro Met Met Gly Gly Tyr Asn Pro Met Met 355 360 365 aat ccg caa gca atg aca gat tac tat caa aag atg caa gaa tat tac 1152 Asn Pro Gln Ala Met Thr Asp Tyr Tyr Gln Lys Met Gln Glu Tyr Tyr 370 375 380 caa caa atg caa aag caa act ggt atg gat tat act caa atg tac caa 1200 Gln Gln Met Gln Lys Gln Thr Gly Met Asp Tyr Thr Gln Met Tyr Gln 385 390 395 400 caa caa atg cag caa atg gca atg atg atg cca ggg ttt gcc atg cca 1248 Gln Gln Met Gln Gln Met Ala Met Met Met Pro Gly Phe Ala Met Pro 405 410 415 cct aat gca atg act tta aac caa cca cag caa gat tca aat gcc act 1296 Pro Asn Ala Met Thr Leu Asn Gln Pro Gln Gln Asp Ser Asn Ala Thr 420 425 430 caa ggt tcc cca gca cct tct gat tcc gat aat aat aaa tcc aat gac 1344 Gln Gly Ser Pro Ala Pro Ser Asp Ser Asp Asn Asn Lys Ser Asn Asp 435 440 445 gtc caa act att ggt aat aca tca aac act gac tct ggt tca ccg cca 1392 Val Gln Thr Ile Gly Asn Thr Ser Asn Thr Asp Ser Gly Ser Pro Pro 450 455 460 ttg aat tta cct aat ggt cca aag ggc cca tca caa tac aat gat gac 1440 Leu Asn Leu Pro Asn Gly Pro Lys Gly Pro Ser Gln Tyr Asn Asp Asp Page 262 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 465 470 475 480 cac aat agc ggt tat ggc tac aac cgt gat cgc ggt gat cgt gat cgt 1488 His Asn Ser Gly Tyr Gly Tyr Asn Arg Asp Arg Gly Asp Arg Asp Arg 485 490 495 aac gat cgt gac cgc gat tac aat cac cgt agt ggt gga aac cat aga 1536 Asn Asp Arg Asp Arg Asp Tyr Asn His Arg Ser Gly Gly Asn His Arg 500 505 510 aga aac ggc cgt ggt ggt cgc ggt gga tac aat aga cgt aat aat ggc 1584 Arg Asn Gly Arg Gly Gly Arg Gly Gly Tyr Asn Arg Arg Asn Asn Gly 515 520 525 tac cat cca tat aat agg taa 1605 Tyr His Pro Tyr Asn Arg 530 <210> 184 <211> 534 <212> PRT <213> Saccharomyces cerevisiae <400> 184 Met Ser Ser Asp Glu Glu Asp Phe Asn Asp Ile Tyr Gly Asp Asp Lys 1 5 10 15 Pro Thr Thr Thr Glu Glu Val Lys Lys Glu Glu Glu Gln Asn Lys Ala 20 25 30 Gly Ser Gly Thr Ser Gln Leu Asp Gln Leu Ala Ala Leu Gln Ala Leu 35 40 45 Ser Ser Ser Leu Asn Lys Leu Asn Asn Pro Asn Ser Asn Asn Ser Ser 50 55 60 Ser Asn Asn Ser Asn Gln Asp Thr Ser Ser Ser Lys Gln Asp Gly Thr 65 70 75 80 Ala Asn Asp Lys Glu Gly Ser Asn Glu Asp Thr Lys Asn Glu Lys Lys 85 90 95 Gln Glu Ser Ala Thr Ser Ala Asn Ala Asn Ala Asn Ala Ser Ser Ala 100 105 110 Gly Pro Ser Gly Leu Pro Trp Glu Gln Leu Gln Gln Thr Met Ser Gln 115 120 125 Phe Gln Gln Pro Ser Ser Gln Ser Pro Pro Gln Gln Gln Val Thr Gln 130 135 140 Thr Lys Glu Glu Arg Ser Lys Ala Asp Leu Ser Lys Glu Ser Cys Lys 145 150 155 160 Met Phe Ile Gly Gly Leu Asn Trp Asp Thr Thr Glu Asp Asn Leu Arg 165 170 175 Page 263 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Tyr Phe Gly Lys Tyr Gly Thr Val Thr Asp Leu Lys Ile Met Lys 180 185 190 Asp Pro Ala Thr Gly Arg Ser Arg Gly Phe Gly Phe Leu Ser Phe Glu 195 200 205 Lys Pro Ser Ser Val Asp Glu Val Val Lys Thr Gln His Ile Leu Asp 210 215 220 Gly Lys Val Ile Asp Pro Lys Arg Ala Ile Pro Arg Asp Glu Gln Asp 225 230 235 240 Lys Thr Gly Lys Ile Phe Val Gly Gly Ile Gly Pro Asp Val Arg Pro 245 250 255 Lys Glu Phe Glu Glu Phe Phe Ser Gln Trp Gly Thr Ile Ile Asp Ala 260 265 270 Gln Leu Met Leu Asp Lys Asp Thr Gly Gln Ser Arg Gly Phe Gly Phe 275 280 285 Val Thr Tyr Asp Ser Ala Asp Ala Val Asp Arg Val Cys Gln Asn Lys 290 295 300 Phe Ile Asp Phe Lys Asp Arg Lys Ile Glu Ile Lys Arg Ala Glu Pro 305 310 315 320 Arg His Met Gln Gln Lys Ser Ser Asn Asn Gly Gly Asn Asn Gly Gly 325 330 335 Asn Asn Met Asn Arg Arg Gly Gly Asn Phe Gly Asn Gln Gly Asp Phe 340 345 350 Asn Gln Met Tyr Gln Asn Pro Met Met Gly Gly Tyr Asn Pro Met Met 355 360 365 Asn Pro Gln Ala Met Thr Asp Tyr Tyr Gln Lys Met Gln Glu Tyr Tyr 370 375 380 Gln Gln Met Gln Lys Gln Thr Gly Met Asp Tyr Thr Gln Met Tyr Gln 385 390 395 400 Gln Gln Met Gln Gln Met Ala Met Met Met Pro Gly Phe Ala Met Pro 405 410 415 Pro Asn Ala Met Thr Leu Asn Gln Pro Gln Gln Asp Ser Asn Ala Thr 420 425 430 Gln Gly Ser Pro Ala Pro Ser Asp Ser Asp Asn Asn Lys Ser Asn Asp 435 440 445 Page 264 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Gln Thr Ile Gly Asn Thr Ser Asn Thr Asp Ser Gly Ser Pro Pro 450 455 460 Leu Asn Leu Pro Asn Gly Pro Lys Gly Pro Ser Gln Tyr Asn Asp Asp 465 470 475 480 His Asn Ser Gly Tyr Gly Tyr Asn Arg Asp Arg Gly Asp Arg Asp Arg 485 490 495 Asn Asp Arg Asp Arg Asp Tyr Asn His Arg Ser Gly Gly Asn His Arg 500 505 510 Arg Asn Gly Arg Gly Gly Arg Gly Gly Tyr Asn Arg Arg Asn Asn Gly 515 520 525 Tyr His Pro Tyr Asn Arg 530 <210> 185 <211> 321 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(321) <400> 185 atg tcc acc ctt ttg aag tct gct aaa tct atc gtt cca ttg atg gac 48 Met Ser Thr Leu Leu Lys Ser Ala Lys Ser Ile Val Pro Leu Met Asp 1 5 10 15 cgt gtc ctt gtc caa aga atc aag gca caa gca aag aca gca tcc ggg 96 Arg Val Leu Val Gln Arg Ile Lys Ala Gln Ala Lys Thr Ala Ser Gly 20 25 30 ttg tat tta cct gaa aag aac gtg gag aag tta aac caa gct gaa gtt 144 Leu Tyr Leu Pro Glu Lys Asn Val Glu Lys Leu Asn Gln Ala Glu Val 35 40 45 gtt gcc gta ggc ccg ggc ttt act gat gct aat ggt aat aag gtt gtt 192 Val Ala Val Gly Pro Gly Phe Thr Asp Ala Asn Gly Asn Lys Val Val 50 55 60 cct caa gtt aaa gtt ggt gac caa gtt ttg att cca cag ttt ggt ggt 240 Pro Gln Val Lys Val Gly Asp Gln Val Leu Ile Pro Gln Phe Gly Gly 65 70 75 80 tct acc att aaa ttg ggt aac gac gat gaa gtt att ctt ttc agg gac 288 Ser Thr Ile Lys Leu Gly Asn Asp Asp Glu Val Ile Leu Phe Arg Asp 85 90 95 gct gaa atc ctg gct aag att gcc aag gac taa 321 Ala Glu Ile Leu Ala Lys Ile Ala Lys Asp 100 105 <210> 186 <211> 106 Page 265 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> PRT <213> Saccharomyces cerevisiae <400> 186 Met Ser Thr Leu Leu Lys Ser Ala Lys Ser Ile Val Pro Leu Met Asp 1 5 10 15 Arg Val Leu Val Gln Arg Ile Lys Ala Gln Ala Lys Thr Ala Ser Gly 20 25 30 Leu Tyr Leu Pro Glu Lys Asn Val Glu Lys Leu Asn Gln Ala Glu Val 35 40 45 Val Ala Val Gly Pro Gly Phe Thr Asp Ala Asn Gly Asn Lys Val Val 50 55 60 Pro Gln Val Lys Val Gly Asp Gln Val Leu Ile Pro Gln Phe Gly Gly 65 70 75 80 Ser Thr Ile Lys Leu Gly Asn Asp Asp Glu Val Ile Leu Phe Arg Asp 85 90 95 Ala Glu Ile Leu Ala Lys Ile Ala Lys Asp 100 105 <210> 187 <211> 1149 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1149) <400> 187 atg gca agt aac cag cac ata gga gct tca aac cta aat gag aat gag 48 Met Ala Ser Asn Gln His Ile Gly Ala Ser Asn Leu Asn Glu Asn Glu 1 5 10 15 gct ata tta acc aac cgc gtt gct gag ctg gaa agg cgt atg tcg atg 96 Ala Ile Leu Thr Asn Arg Val Ala Glu Leu Glu Arg Arg Met Ser Met 20 25 30 ttt gag ggt ata ttt cac gcg tta agt aac cgt ctc gat ctt cac ttt 144 Phe Glu Gly Ile Phe His Ala Leu Ser Asn Arg Leu Asp Leu His Phe 35 40 45 aaa aaa tat gat gta gtg gta aac tcc caa cag caa caa atc aac gaa 192 Lys Lys Tyr Asp Val Val Val Asn Ser Gln Gln Gln Gln Ile Asn Glu 50 55 60 ctg acc gcg ttt tta tca aca ttg ctg aat gac caa caa cgc cac gct 240 Leu Thr Ala Phe Leu Ser Thr Leu Leu Asn Asp Gln Gln Arg His Ala 65 70 75 80 gaa att ctc agt gaa aaa tta agc gga acg ttg cat ggg gtg tca gct 288 Glu Ile Leu Ser Glu Lys Leu Ser Gly Thr Leu His Gly Val Ser Ala 85 90 95 Page 266 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt acg tca ata tcc tta agc caa act ctt gac cca caa ggc ttc act gat 336 Thr Ser Ile Ser Leu Ser Gln Thr Leu Asp Pro Gln Gly Phe Thr Asp 100 105 110 gga act acg gca cca gga gct cct agg aat tat act tca gtg cct atg 384 Gly Thr Thr Ala Pro Gly Ala Pro Arg Asn Tyr Thr Ser Val Pro Met 115 120 125 aat aat gat caa act gct cat ccg caa aat gaa gga gct gtt agt aat 432 Asn Asn Asp Gln Thr Ala His Pro Gln Asn Glu Gly Ala Val Ser Asn 130 135 140 gaa aca ctt ttt gag gac att ttg aat gga aat tca caa gaa aat gat 480 Glu Thr Leu Phe Glu Asp Ile Leu Asn Gly Asn Ser Gln Glu Asn Asp 145 150 155 160 aag agt caa caa caa act aac agc tca aat tct ata agc caa gaa aat 528 Lys Ser Gln Gln Gln Thr Asn Ser Ser Asn Ser Ile Ser Gln Glu Asn 165 170 175 aat agc acc aac cct tca gtg gac act cgg ttc aac aag ccg caa aat 576 Asn Ser Thr Asn Pro Ser Val Asp Thr Arg Phe Asn Lys Pro Gln Asn 180 185 190 tat aat tcc aat tta gtc cca tcc ttg gaa gag tat tca gca aat cca 624 Tyr Asn Ser Asn Leu Val Pro Ser Leu Glu Glu Tyr Ser Ala Asn Pro 195 200 205 cct aac aat gat ggt ggc caa agt caa gga ctg tac ata agc agc aac 672 Pro Asn Asn Asp Gly Gly Gln Ser Gln Gly Leu Tyr Ile Ser Ser Asn 210 215 220 tct tct caa tca cgg cag tct cct aat ctc cag aaa gtt tct cct aac 720 Ser Ser Gln Ser Arg Gln Ser Pro Asn Leu Gln Lys Val Ser Pro Asn 225 230 235 240 cat gaa aat gcg gtt gaa tca aat gca caa gag agc gtg ccg aca ttt 768 His Glu Asn Ala Val Glu Ser Asn Ala Gln Glu Ser Val Pro Thr Phe 245 250 255 gag gag gaa cag tat gag act aaa aca gga ttg aaa cgg aaa cga ata 816 Glu Glu Glu Gln Tyr Glu Thr Lys Thr Gly Leu Lys Arg Lys Arg Ile 260 265 270 gtc tgc aca aga ccc ttc gaa ttt atc aag tca cca cac tct gtg atg 864 Val Cys Thr Arg Pro Phe Glu Phe Ile Lys Ser Pro His Ser Val Met 275 280 285 gag gtt tgg aag gag tat aca gaa ggt gtt aac ggg cag cct tct ata 912 Glu Val Trp Lys Glu Tyr Thr Glu Gly Val Asn Gly Gln Pro Ser Ile 290 295 300 agg aaa atg gaa gct ctt tat caa acg gca tgg agg cga gat cca gca 960 Arg Lys Met Glu Ala Leu Tyr Gln Thr Ala Trp Arg Arg Asp Pro Ala 305 310 315 320 gta aat aaa aga tat tcg aga aga aag gtt ctt tgg aaa gcc att caa 1008 Val Asn Lys Arg Tyr Ser Arg Arg Lys Val Leu Trp Lys Ala Ile Gln 325 330 335 act ggc ctt aat cgt ggg tat tca tta aac tat gtt gtt gaa ata tta 1056 Thr Gly Leu Asn Arg Gly Tyr Ser Leu Asn Tyr Val Val Glu Ile Leu 340 345 350 gaa aac tca aga tat gtt aat gat aaa cag aag gtt aaa caa cct att 1104 Glu Asn Ser Arg Tyr Val Asn Asp Lys Gln Lys Val Lys Gln Pro Ile 355 360 365 Page 267 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggt tgg tta tgc cac agt tct cat att cca gag act ttg aag tga 1149 Gly Trp Leu Cys His Ser Ser His Ile Pro Glu Thr Leu Lys 370 375 380 <210> 188 <211> 382 <212> PRT <213> Saccharomyces cerevisiae <400> 188 Met Ala Ser Asn Gln His Ile Gly Ala Ser Asn Leu Asn Glu Asn Glu 1 5 10 15 Ala Ile Leu Thr Asn Arg Val Ala Glu Leu Glu Arg Arg Met Ser Met 20 25 30 Phe Glu Gly Ile Phe His Ala Leu Ser Asn Arg Leu Asp Leu His Phe 35 40 45 Lys Lys Tyr Asp Val Val Val Asn Ser Gln Gln Gln Gln Ile Asn Glu 50 55 60 Leu Thr Ala Phe Leu Ser Thr Leu Leu Asn Asp Gln Gln Arg His Ala 65 70 75 80 Glu Ile Leu Ser Glu Lys Leu Ser Gly Thr Leu His Gly Val Ser Ala 85 90 95 Thr Ser Ile Ser Leu Ser Gln Thr Leu Asp Pro Gln Gly Phe Thr Asp 100 105 110 Gly Thr Thr Ala Pro Gly Ala Pro Arg Asn Tyr Thr Ser Val Pro Met 115 120 125 Asn Asn Asp Gln Thr Ala His Pro Gln Asn Glu Gly Ala Val Ser Asn 130 135 140 Glu Thr Leu Phe Glu Asp Ile Leu Asn Gly Asn Ser Gln Glu Asn Asp 145 150 155 160 Lys Ser Gln Gln Gln Thr Asn Ser Ser Asn Ser Ile Ser Gln Glu Asn 165 170 175 Asn Ser Thr Asn Pro Ser Val Asp Thr Arg Phe Asn Lys Pro Gln Asn 180 185 190 Tyr Asn Ser Asn Leu Val Pro Ser Leu Glu Glu Tyr Ser Ala Asn Pro 195 200 205 Pro Asn Asn Asp Gly Gly Gln Ser Gln Gly Leu Tyr Ile Ser Ser Asn 210 215 220 Page 268 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Ser Gln Ser Arg Gln Ser Pro Asn Leu Gln Lys Val Ser Pro Asn 225 230 235 240 His Glu Asn Ala Val Glu Ser Asn Ala Gln Glu Ser Val Pro Thr Phe 245 250 255 Glu Glu Glu Gln Tyr Glu Thr Lys Thr Gly Leu Lys Arg Lys Arg Ile 260 265 270 Val Cys Thr Arg Pro Phe Glu Phe Ile Lys Ser Pro His Ser Val Met 275 280 285 Glu Val Trp Lys Glu Tyr Thr Glu Gly Val Asn Gly Gln Pro Ser Ile 290 295 300 Arg Lys Met Glu Ala Leu Tyr Gln Thr Ala Trp Arg Arg Asp Pro Ala 305 310 315 320 Val Asn Lys Arg Tyr Ser Arg Arg Lys Val Leu Trp Lys Ala Ile Gln 325 330 335 Thr Gly Leu Asn Arg Gly Tyr Ser Leu Asn Tyr Val Val Glu Ile Leu 340 345 350 Glu Asn Ser Arg Tyr Val Asn Asp Lys Gln Lys Val Lys Gln Pro Ile 355 360 365 Gly Trp Leu Cys His Ser Ser His Ile Pro Glu Thr Leu Lys 370 375 380 <210> 189 <211> 729 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(729) <400> 189 atg ata aaa aac tat ttg gga cga aga tgg ctc aat aat cct gca att 48 Met Ile Lys Asn Tyr Leu Gly Arg Arg Trp Leu Asn Asn Pro Ala Ile 1 5 10 15 caa gca tat gtg aaa caa aat gct gct gtc gcc cat tct acg gtg ttt 96 Gln Ala Tyr Val Lys Gln Asn Ala Ala Val Ala His Ser Thr Val Phe 20 25 30 caa gga aat ctt tat gaa tat acg gtg atg agg gag tta tct gag aaa 144 Gln Gly Asn Leu Tyr Glu Tyr Thr Val Met Arg Glu Leu Ser Glu Lys 35 40 45 cta cga atg aca aag ttg aga aaa acc ggt ggc gcc cat gat ggt ggc 192 Leu Arg Met Thr Lys Leu Arg Lys Thr Gly Gly Ala His Asp Gly Gly 50 55 60 gta gac ata aag gga agc tgg cca gta gat gat att tat tgg aaa att 240 Page 269 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Asp Ile Lys Gly Ser Trp Pro Val Asp Asp Ile Tyr Trp Lys Ile 65 70 75 80 tca tcg tta atg ccc aat ttg gaa atg gct agt aac ata aaa aga acg 288 Ser Ser Leu Met Pro Asn Leu Glu Met Ala Ser Asn Ile Lys Arg Thr 85 90 95 aac tcg caa aat ggc ttc gta ttg aaa cct tta aag tat agg ata atc 336 Asn Ser Gln Asn Gly Phe Val Leu Lys Pro Leu Lys Tyr Arg Ile Ile 100 105 110 gac cat act ttt gaa cca ttg aaa gta cta gtc caa tgt aag gct ttc 384 Asp His Thr Phe Glu Pro Leu Lys Val Leu Val Gln Cys Lys Ala Phe 115 120 125 act aaa tca aaa tta tct cct aga gaa ttc cgt gag tta gta gga aca 432 Thr Lys Ser Lys Leu Ser Pro Arg Glu Phe Arg Glu Leu Val Gly Thr 130 135 140 ttc acc tca cta gta tca cat agt caa cgc aac aaa aca gta tgc att 480 Phe Thr Ser Leu Val Ser His Ser Gln Arg Asn Lys Thr Val Cys Ile 145 150 155 160 atg tgt tcc cct cat atg tta aca aaa gat acc tta aat ctt atc aat 528 Met Cys Ser Pro His Met Leu Thr Lys Asp Thr Leu Asn Leu Ile Asn 165 170 175 aac atc acg ctt cct ctg ata tat tta cgt gtt gag atg ctg aaa gag 576 Asn Ile Thr Leu Pro Leu Ile Tyr Leu Arg Val Glu Met Leu Lys Glu 180 185 190 aag act gac ggg cac ttt gac tta atc aat tca gga aaa cta att aat 624 Lys Thr Asp Gly His Phe Asp Leu Ile Asn Ser Gly Lys Leu Ile Asn 195 200 205 tat tac gag aat tca tac gcc tct acg tta atg caa gat tgc aag att 672 Tyr Tyr Glu Asn Ser Tyr Ala Ser Thr Leu Met Gln Asp Cys Lys Ile 210 215 220 tct gaa tgg ctg aag ttg aag ttg tac aaa aat agt gac ttt aat tcg 720 Ser Glu Trp Leu Lys Leu Lys Leu Tyr Lys Asn Ser Asp Phe Asn Ser 225 230 235 240 gaa aaa taa 729 Glu Lys <210> 190 <211> 242 <212> PRT <213> Saccharomyces cerevisiae <400> 190 Met Ile Lys Asn Tyr Leu Gly Arg Arg Trp Leu Asn Asn Pro Ala Ile 1 5 10 15 Gln Ala Tyr Val Lys Gln Asn Ala Ala Val Ala His Ser Thr Val Phe 20 25 30 Gln Gly Asn Leu Tyr Glu Tyr Thr Val Met Arg Glu Leu Ser Glu Lys 35 40 45 Leu Arg Met Thr Lys Leu Arg Lys Thr Gly Gly Ala His Asp Gly Gly Page 270 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 50 55 60 Val Asp Ile Lys Gly Ser Trp Pro Val Asp Asp Ile Tyr Trp Lys Ile 65 70 75 80 Ser Ser Leu Met Pro Asn Leu Glu Met Ala Ser Asn Ile Lys Arg Thr 85 90 95 Asn Ser Gln Asn Gly Phe Val Leu Lys Pro Leu Lys Tyr Arg Ile Ile 100 105 110 Asp His Thr Phe Glu Pro Leu Lys Val Leu Val Gln Cys Lys Ala Phe 115 120 125 Thr Lys Ser Lys Leu Ser Pro Arg Glu Phe Arg Glu Leu Val Gly Thr 130 135 140 Phe Thr Ser Leu Val Ser His Ser Gln Arg Asn Lys Thr Val Cys Ile 145 150 155 160 Met Cys Ser Pro His Met Leu Thr Lys Asp Thr Leu Asn Leu Ile Asn 165 170 175 Asn Ile Thr Leu Pro Leu Ile Tyr Leu Arg Val Glu Met Leu Lys Glu 180 185 190 Lys Thr Asp Gly His Phe Asp Leu Ile Asn Ser Gly Lys Leu Ile Asn 195 200 205 Tyr Tyr Glu Asn Ser Tyr Ala Ser Thr Leu Met Gln Asp Cys Lys Ile 210 215 220 Ser Glu Trp Leu Lys Leu Lys Leu Tyr Lys Asn Ser Asp Phe Asn Ser 225 230 235 240 Glu Lys <210> 191 <211> 630 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(630) <400> 191 atg ata tca cca tca aaa aag aga acc att tta tca agc aag aat ata 48 Met Ile Ser Pro Ser Lys Lys Arg Thr Ile Leu Ser Ser Lys Asn Ile 1 5 10 15 aac caa aaa cca cga gca gtg gta aaa ggc aat gaa ctt cgt tca cca 96 Asn Gln Lys Pro Arg Ala Val Val Lys Gly Asn Glu Leu Arg Ser Pro Page 271 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 tca aag aga agg tca caa ata gac aca gac tat gca cta agg cga agt 144 Ser Lys Arg Arg Ser Gln Ile Asp Thr Asp Tyr Ala Leu Arg Arg Ser 35 40 45 cca ata aag aca atc caa att tct aaa gct gca caa ttt atg ctg tat 192 Pro Ile Lys Thr Ile Gln Ile Ser Lys Ala Ala Gln Phe Met Leu Tyr 50 55 60 gag gaa acg gct gaa gaa aga aac ata gct gtc cac aga cat aat gaa 240 Glu Glu Thr Ala Glu Glu Arg Asn Ile Ala Val His Arg His Asn Glu 65 70 75 80 ata tac aat aat aac aat tct gtg agc aat gag aat aat cct tcc caa 288 Ile Tyr Asn Asn Asn Asn Ser Val Ser Asn Glu Asn Asn Pro Ser Gln 85 90 95 gta aaa gaa aac ctt tca ccc gct aaa att tgc cct tat gaa aga gca 336 Val Lys Glu Asn Leu Ser Pro Ala Lys Ile Cys Pro Tyr Glu Arg Ala 100 105 110 ttt tta agg gaa gga gga aga att gca ttg aag gac tta agt gtt gac 384 Phe Leu Arg Glu Gly Gly Arg Ile Ala Leu Lys Asp Leu Ser Val Asp 115 120 125 gaa ttc aaa ggt tac ata cag gat cct ctc acc gat gag act ata cca 432 Glu Phe Lys Gly Tyr Ile Gln Asp Pro Leu Thr Asp Glu Thr Ile Pro 130 135 140 ctg acg ttg cca ctg ggt gat aaa aaa atc agc cta ccc agt ttt ata 480 Leu Thr Leu Pro Leu Gly Asp Lys Lys Ile Ser Leu Pro Ser Phe Ile 145 150 155 160 acg ccg cca aga aat tcg aag ata tct att ttc ttc act agt aaa cac 528 Thr Pro Pro Arg Asn Ser Lys Ile Ser Ile Phe Phe Thr Ser Lys His 165 170 175 caa gga cag aac cca gag aca aag ata tcc cgt tct acc gat gac gtc 576 Gln Gly Gln Asn Pro Glu Thr Lys Ile Ser Arg Ser Thr Asp Asp Val 180 185 190 agt gaa aaa aaa gta gtg aga aaa ctg tcc ttc cac gtc tat gaa gat 624 Ser Glu Lys Lys Val Val Arg Lys Leu Ser Phe His Val Tyr Glu Asp 195 200 205 gag taa 630 Glu <210> 192 <211> 209 <212> PRT <213> Saccharomyces cerevisiae <400> 192 Met Ile Ser Pro Ser Lys Lys Arg Thr Ile Leu Ser Ser Lys Asn Ile 1 5 10 15 Asn Gln Lys Pro Arg Ala Val Val Lys Gly Asn Glu Leu Arg Ser Pro 20 25 30 Ser Lys Arg Arg Ser Gln Ile Asp Thr Asp Tyr Ala Leu Arg Arg Ser 35 40 45 Page 272 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Ile Lys Thr Ile Gln Ile Ser Lys Ala Ala Gln Phe Met Leu Tyr 50 55 60 Glu Glu Thr Ala Glu Glu Arg Asn Ile Ala Val His Arg His Asn Glu 65 70 75 80 Ile Tyr Asn Asn Asn Asn Ser Val Ser Asn Glu Asn Asn Pro Ser Gln 85 90 95 Val Lys Glu Asn Leu Ser Pro Ala Lys Ile Cys Pro Tyr Glu Arg Ala 100 105 110 Phe Leu Arg Glu Gly Gly Arg Ile Ala Leu Lys Asp Leu Ser Val Asp 115 120 125 Glu Phe Lys Gly Tyr Ile Gln Asp Pro Leu Thr Asp Glu Thr Ile Pro 130 135 140 Leu Thr Leu Pro Leu Gly Asp Lys Lys Ile Ser Leu Pro Ser Phe Ile 145 150 155 160 Thr Pro Pro Arg Asn Ser Lys Ile Ser Ile Phe Phe Thr Ser Lys His 165 170 175 Gln Gly Gln Asn Pro Glu Thr Lys Ile Ser Arg Ser Thr Asp Asp Val 180 185 190 Ser Glu Lys Lys Val Val Arg Lys Leu Ser Phe His Val Tyr Glu Asp 195 200 205 Glu <210> 193 <211> 621 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(621) <400> 193 atg atg ccc tac aac acc cct cca aat atc caa gaa cct atg aac ttc 48 Met Met Pro Tyr Asn Thr Pro Pro Asn Ile Gln Glu Pro Met Asn Phe 1 5 10 15 gca agc agc aac ccc ttt ggt att att cca gat gcg ctc agt ttc cag 96 Ala Ser Ser Asn Pro Phe Gly Ile Ile Pro Asp Ala Leu Ser Phe Gln 20 25 30 aat ttc aaa tat gat cgt ctt cag cag cag caa cag cag cag caa cag 144 Asn Phe Lys Tyr Asp Arg Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 35 40 45 Page 273 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cag caa caa aat cgc act gcg tca tcg tta cag cag ccg caa cag caa 192 Gln Gln Gln Asn Arg Thr Ala Ser Ser Leu Gln Gln Pro Gln Gln Gln 50 55 60 caa cca ata agc ccg cct ttg ttt tta gta ggg gcc ggt acc agc gaa 240 Gln Pro Ile Ser Pro Pro Leu Phe Leu Val Gly Ala Gly Thr Ser Glu 65 70 75 80 aac tca aac ctt aac aag aat gcc aac act agt act atc cct cct tta 288 Asn Ser Asn Leu Asn Lys Asn Ala Asn Thr Ser Thr Ile Pro Pro Leu 85 90 95 ctc ttt agc aga tcg tct cag cat tat gtt gtc cca gat ata gac cac 336 Leu Phe Ser Arg Ser Ser Gln His Tyr Val Val Pro Asp Ile Asp His 100 105 110 tcc tcc ata ata tac aag aac aac atc tgc aaa tct ttc aaa gat gac 384 Ser Ser Ile Ile Tyr Lys Asn Asn Ile Cys Lys Ser Phe Lys Asp Asp 115 120 125 tta ttt ttc tgt cca aga tct tta ctt tct ctc gaa gaa caa caa gca 432 Leu Phe Phe Cys Pro Arg Ser Leu Leu Ser Leu Glu Glu Gln Gln Ala 130 135 140 tgc gag aaa atg gat agg ctg acc gct gaa caa atg tca ttg tat cat 480 Cys Glu Lys Met Asp Arg Leu Thr Ala Glu Gln Met Ser Leu Tyr His 145 150 155 160 cag aac acg caa tcc agt tct aat cct ggt tct atg tct tct tca cct 528 Gln Asn Thr Gln Ser Ser Ser Asn Pro Gly Ser Met Ser Ser Ser Pro 165 170 175 cca aat tct gct tct tct ata ttc aac tct agg ccg aag ttc aat cct 576 Pro Asn Ser Ala Ser Ser Ile Phe Asn Ser Arg Pro Lys Phe Asn Pro 180 185 190 tat aca tct caa agt ttt aat cct ttg gaa agt gtt caa gaa tga 621 Tyr Thr Ser Gln Ser Phe Asn Pro Leu Glu Ser Val Gln Glu 195 200 205 <210> 194 <211> 206 <212> PRT <213> Saccharomyces cerevisiae <400> 194 Met Met Pro Tyr Asn Thr Pro Pro Asn Ile Gln Glu Pro Met Asn Phe 1 5 10 15 Ala Ser Ser Asn Pro Phe Gly Ile Ile Pro Asp Ala Leu Ser Phe Gln 20 25 30 Asn Phe Lys Tyr Asp Arg Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 35 40 45 Gln Gln Gln Asn Arg Thr Ala Ser Ser Leu Gln Gln Pro Gln Gln Gln 50 55 60 Gln Pro Ile Ser Pro Pro Leu Phe Leu Val Gly Ala Gly Thr Ser Glu 65 70 75 80 Page 274 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Ser Asn Leu Asn Lys Asn Ala Asn Thr Ser Thr Ile Pro Pro Leu 85 90 95 Leu Phe Ser Arg Ser Ser Gln His Tyr Val Val Pro Asp Ile Asp His 100 105 110 Ser Ser Ile Ile Tyr Lys Asn Asn Ile Cys Lys Ser Phe Lys Asp Asp 115 120 125 Leu Phe Phe Cys Pro Arg Ser Leu Leu Ser Leu Glu Glu Gln Gln Ala 130 135 140 Cys Glu Lys Met Asp Arg Leu Thr Ala Glu Gln Met Ser Leu Tyr His 145 150 155 160 Gln Asn Thr Gln Ser Ser Ser Asn Pro Gly Ser Met Ser Ser Ser Pro 165 170 175 Pro Asn Ser Ala Ser Ser Ile Phe Asn Ser Arg Pro Lys Phe Asn Pro 180 185 190 Tyr Thr Ser Gln Ser Phe Asn Pro Leu Glu Ser Val Gln Glu 195 200 205 <210> 195 <211> 534 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(534) <400> 195 atg aaa ctg gcg caa gac atg aat gta gat gaa ata ttt ctc aaa caa 48 Met Lys Leu Ala Gln Asp Met Asn Val Asp Glu Ile Phe Leu Lys Gln 1 5 10 15 gcg gca gaa gct ata gcg gta atc tca tca agt ccc act cat acg gac 96 Ala Ala Glu Ala Ile Ala Val Ile Ser Ser Ser Pro Thr His Thr Asp 20 25 30 ccc ata ata cga gag cta ctc cac aga att cga caa tcc agc cca ttg 144 Pro Ile Ile Arg Glu Leu Leu His Arg Ile Arg Gln Ser Ser Pro Leu 35 40 45 agc gca gtt ata cca gca cca gaa aat gtt tta aag gct ggg gag ccg 192 Ser Ala Val Ile Pro Ala Pro Glu Asn Val Leu Lys Ala Gly Glu Pro 50 55 60 gaa aat atg gct aga ggt ctt ata agg att cca gaa aca caa aca aaa 240 Glu Asn Met Ala Arg Gly Leu Ile Arg Ile Pro Glu Thr Gln Thr Lys 65 70 75 80 aga aca gga ggt aac aac cat agc aag gaa ggc gca cag ctc tac agc 288 Arg Thr Gly Gly Asn Asn His Ser Lys Glu Gly Ala Gln Leu Tyr Ser 85 90 95 Page 275 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tgt gcg aaa tgt cag ttg aaa ttc agc aga agt tct gat ctg aga aga 336 Cys Ala Lys Cys Gln Leu Lys Phe Ser Arg Ser Ser Asp Leu Arg Arg 100 105 110 cat gaa aag gta cac tca ctc gtg ctg ccg cat att tgc tca aac tgt 384 His Glu Lys Val His Ser Leu Val Leu Pro His Ile Cys Ser Asn Cys 115 120 125 ggc aaa ggg ttt gcc agg aag gat gct cta aaa aga cat tct aac aca 432 Gly Lys Gly Phe Ala Arg Lys Asp Ala Leu Lys Arg His Ser Asn Thr 130 135 140 ctg acc tgt caa aga aac aga aag aaa cta agt gaa ggt tca gac gtt 480 Leu Thr Cys Gln Arg Asn Arg Lys Lys Leu Ser Glu Gly Ser Asp Val 145 150 155 160 gat gta gat gag ctc atc aag gat gcg ata aag aat ggt acc ggc ctg 528 Asp Val Asp Glu Leu Ile Lys Asp Ala Ile Lys Asn Gly Thr Gly Leu 165 170 175 ttg taa 534 Leu <210> 196 <211> 177 <212> PRT <213> Saccharomyces cerevisiae <400> 196 Met Lys Leu Ala Gln Asp Met Asn Val Asp Glu Ile Phe Leu Lys Gln 1 5 10 15 Ala Ala Glu Ala Ile Ala Val Ile Ser Ser Ser Pro Thr His Thr Asp 20 25 30 Pro Ile Ile Arg Glu Leu Leu His Arg Ile Arg Gln Ser Ser Pro Leu 35 40 45 Ser Ala Val Ile Pro Ala Pro Glu Asn Val Leu Lys Ala Gly Glu Pro 50 55 60 Glu Asn Met Ala Arg Gly Leu Ile Arg Ile Pro Glu Thr Gln Thr Lys 65 70 75 80 Arg Thr Gly Gly Asn Asn His Ser Lys Glu Gly Ala Gln Leu Tyr Ser 85 90 95 Cys Ala Lys Cys Gln Leu Lys Phe Ser Arg Ser Ser Asp Leu Arg Arg 100 105 110 His Glu Lys Val His Ser Leu Val Leu Pro His Ile Cys Ser Asn Cys 115 120 125 Gly Lys Gly Phe Ala Arg Lys Asp Ala Leu Lys Arg His Ser Asn Thr 130 135 140 Page 276 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Thr Cys Gln Arg Asn Arg Lys Lys Leu Ser Glu Gly Ser Asp Val 145 150 155 160 Asp Val Asp Glu Leu Ile Lys Asp Ala Ile Lys Asn Gly Thr Gly Leu 165 170 175 Leu <210> 197 <211> 1425 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1425) <400> 197 atg gag gta act tca atg ttt ctc aat aga atg atg aag acc agg act 48 Met Glu Val Thr Ser Met Phe Leu Asn Arg Met Met Lys Thr Arg Thr 1 5 10 15 ggt ctt tat cgc tta tat tca acc ctt aaa gtt cca cat gta gaa atc 96 Gly Leu Tyr Arg Leu Tyr Ser Thr Leu Lys Val Pro His Val Glu Ile 20 25 30 aat ggc ata aaa tac aag acc gac cca cag act acc aat gtt aca gat 144 Asn Gly Ile Lys Tyr Lys Thr Asp Pro Gln Thr Thr Asn Val Thr Asp 35 40 45 tca ata ata aag ctt acc gac aga tca tta cat ttg aaa gaa tca cat 192 Ser Ile Ile Lys Leu Thr Asp Arg Ser Leu His Leu Lys Glu Ser His 50 55 60 cca gta ggc att ctt cgc gat cta att gaa aag aaa tta aac tca gtc 240 Pro Val Gly Ile Leu Arg Asp Leu Ile Glu Lys Lys Leu Asn Ser Val 65 70 75 80 gac aac aca ttt aag atc ttt aat aat ttc aag ccc gtg gta acc aca 288 Asp Asn Thr Phe Lys Ile Phe Asn Asn Phe Lys Pro Val Val Thr Thr 85 90 95 atg gaa aac ttc gat tct tta ggg ttt cct aag gat cat cct gga aga 336 Met Glu Asn Phe Asp Ser Leu Gly Phe Pro Lys Asp His Pro Gly Arg 100 105 110 tca aaa tct gac aca tat tat ata aat gag acg cac cta ctg aga aca 384 Ser Lys Ser Asp Thr Tyr Tyr Ile Asn Glu Thr His Leu Leu Arg Thr 115 120 125 cat act tca gcc cac gaa tta gag tgc ttt caa aaa ata aga aac gat 432 His Thr Ser Ala His Glu Leu Glu Cys Phe Gln Lys Ile Arg Asn Asp 130 135 140 tca gat aat att aaa agt gga ttt tta ata tct gca gat gtg tac aga 480 Ser Asp Asn Ile Lys Ser Gly Phe Leu Ile Ser Ala Asp Val Tyr Arg 145 150 155 160 aga gat gaa att gac aaa act cac tat ccg gta ttc cac caa atg gaa 528 Arg Asp Glu Ile Asp Lys Thr His Tyr Pro Val Phe His Gln Met Glu 165 170 175 gga gcc aca att tgg aaa cga acg aag gct gat gtg ggc gta aag gag 576 Page 277 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Ala Thr Ile Trp Lys Arg Thr Lys Ala Asp Val Gly Val Lys Glu 180 185 190 cca atg tat atc gag aaa atc cgt gaa gat atc aga cag gta gag aac 624 Pro Met Tyr Ile Glu Lys Ile Arg Glu Asp Ile Arg Gln Val Glu Asn 195 200 205 ctt tta aat aaa gaa aat gta aag att acg gtt gac gat gat act ata 672 Leu Leu Asn Lys Glu Asn Val Lys Ile Thr Val Asp Asp Asp Thr Ile 210 215 220 cct ttg aaa gaa aat aat cct aaa caa gag tat atg tcc gat ctg gag 720 Pro Leu Lys Glu Asn Asn Pro Lys Gln Glu Tyr Met Ser Asp Leu Glu 225 230 235 240 gtt gat ttg tgc tct caa cat ttg aag agg tcc att gaa ctg ata gtt 768 Val Asp Leu Cys Ser Gln His Leu Lys Arg Ser Ile Glu Leu Ile Val 245 250 255 tct gaa gtt ttt aac aaa aaa ata tct agc atg atc aag aac aaa gcg 816 Ser Glu Val Phe Asn Lys Lys Ile Ser Ser Met Ile Lys Asn Lys Ala 260 265 270 aat aat aca ccc aaa gag cta aaa gtc cgt tgg att aac gct tac ttc 864 Asn Asn Thr Pro Lys Glu Leu Lys Val Arg Trp Ile Asn Ala Tyr Phe 275 280 285 ccc tgg acc gcg ccc tca tgg gaa ata gag gtt tgg tgg cag ggc gaa 912 Pro Trp Thr Ala Pro Ser Trp Glu Ile Glu Val Trp Trp Gln Gly Glu 290 295 300 tgg ctc gaa ctc tgc gga tgc gga ttg att cgt caa gat gtg cta cta 960 Trp Leu Glu Leu Cys Gly Cys Gly Leu Ile Arg Gln Asp Val Leu Leu 305 310 315 320 aga gcc gga tat aaa cct tct gaa aca att ggg tgg gct ttt ggc ttg 1008 Arg Ala Gly Tyr Lys Pro Ser Glu Thr Ile Gly Trp Ala Phe Gly Leu 325 330 335 ggt ttg gac cgc att gct atg ctt ctt ttt gaa att cca gat att aga 1056 Gly Leu Asp Arg Ile Ala Met Leu Leu Phe Glu Ile Pro Asp Ile Arg 340 345 350 ctg ctt tgg agt cgt gat gaa aga ttt tca aga caa ttc tcc aag gga 1104 Leu Leu Trp Ser Arg Asp Glu Arg Phe Ser Arg Gln Phe Ser Lys Gly 355 360 365 tta att act tcc ttc aaa cct tat tca aaa cac ccg gga tca ttt agg 1152 Leu Ile Thr Ser Phe Lys Pro Tyr Ser Lys His Pro Gly Ser Phe Arg 370 375 380 gat gtt gcg ttt tgg tta cca gaa gat aaa cca gat att cat caa gtt 1200 Asp Val Ala Phe Trp Leu Pro Glu Asp Lys Pro Asp Ile His Gln Val 385 390 395 400 cat gaa aat gat ttg atg gaa att atc aga aat ata gct ggc gat ttg 1248 His Glu Asn Asp Leu Met Glu Ile Ile Arg Asn Ile Ala Gly Asp Leu 405 410 415 gta gag agt gtc aag cta gtc gat agc ttt acg cat ccg aaa act ggg 1296 Val Glu Ser Val Lys Leu Val Asp Ser Phe Thr His Pro Lys Thr Gly 420 425 430 aga aaa tct atg tgc tac agg atc aac tat caa tca atg gac aga aat 1344 Arg Lys Ser Met Cys Tyr Arg Ile Asn Tyr Gln Ser Met Asp Arg Asn 435 440 445 ttg aca aac gcc gaa gtt aac act ttg caa gac atg gtg tgt tct aaa 1392 Page 278 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Thr Asn Ala Glu Val Asn Thr Leu Gln Asp Met Val Cys Ser Lys 450 455 460 ttg gta aaa gaa tac agc gta gaa ctc aga tag 1425 Leu Val Lys Glu Tyr Ser Val Glu Leu Arg 465 470 <210> 198 <211> 474 <212> PRT <213> Saccharomyces cerevisiae <400> 198 Met Glu Val Thr Ser Met Phe Leu Asn Arg Met Met Lys Thr Arg Thr 1 5 10 15 Gly Leu Tyr Arg Leu Tyr Ser Thr Leu Lys Val Pro His Val Glu Ile 20 25 30 Asn Gly Ile Lys Tyr Lys Thr Asp Pro Gln Thr Thr Asn Val Thr Asp 35 40 45 Ser Ile Ile Lys Leu Thr Asp Arg Ser Leu His Leu Lys Glu Ser His 50 55 60 Pro Val Gly Ile Leu Arg Asp Leu Ile Glu Lys Lys Leu Asn Ser Val 65 70 75 80 Asp Asn Thr Phe Lys Ile Phe Asn Asn Phe Lys Pro Val Val Thr Thr 85 90 95 Met Glu Asn Phe Asp Ser Leu Gly Phe Pro Lys Asp His Pro Gly Arg 100 105 110 Ser Lys Ser Asp Thr Tyr Tyr Ile Asn Glu Thr His Leu Leu Arg Thr 115 120 125 His Thr Ser Ala His Glu Leu Glu Cys Phe Gln Lys Ile Arg Asn Asp 130 135 140 Ser Asp Asn Ile Lys Ser Gly Phe Leu Ile Ser Ala Asp Val Tyr Arg 145 150 155 160 Arg Asp Glu Ile Asp Lys Thr His Tyr Pro Val Phe His Gln Met Glu 165 170 175 Gly Ala Thr Ile Trp Lys Arg Thr Lys Ala Asp Val Gly Val Lys Glu 180 185 190 Pro Met Tyr Ile Glu Lys Ile Arg Glu Asp Ile Arg Gln Val Glu Asn 195 200 205 Leu Leu Asn Lys Glu Asn Val Lys Ile Thr Val Asp Asp Asp Thr Ile Page 279 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 210 215 220 Pro Leu Lys Glu Asn Asn Pro Lys Gln Glu Tyr Met Ser Asp Leu Glu 225 230 235 240 Val Asp Leu Cys Ser Gln His Leu Lys Arg Ser Ile Glu Leu Ile Val 245 250 255 Ser Glu Val Phe Asn Lys Lys Ile Ser Ser Met Ile Lys Asn Lys Ala 260 265 270 Asn Asn Thr Pro Lys Glu Leu Lys Val Arg Trp Ile Asn Ala Tyr Phe 275 280 285 Pro Trp Thr Ala Pro Ser Trp Glu Ile Glu Val Trp Trp Gln Gly Glu 290 295 300 Trp Leu Glu Leu Cys Gly Cys Gly Leu Ile Arg Gln Asp Val Leu Leu 305 310 315 320 Arg Ala Gly Tyr Lys Pro Ser Glu Thr Ile Gly Trp Ala Phe Gly Leu 325 330 335 Gly Leu Asp Arg Ile Ala Met Leu Leu Phe Glu Ile Pro Asp Ile Arg 340 345 350 Leu Leu Trp Ser Arg Asp Glu Arg Phe Ser Arg Gln Phe Ser Lys Gly 355 360 365 Leu Ile Thr Ser Phe Lys Pro Tyr Ser Lys His Pro Gly Ser Phe Arg 370 375 380 Asp Val Ala Phe Trp Leu Pro Glu Asp Lys Pro Asp Ile His Gln Val 385 390 395 400 His Glu Asn Asp Leu Met Glu Ile Ile Arg Asn Ile Ala Gly Asp Leu 405 410 415 Val Glu Ser Val Lys Leu Val Asp Ser Phe Thr His Pro Lys Thr Gly 420 425 430 Arg Lys Ser Met Cys Tyr Arg Ile Asn Tyr Gln Ser Met Asp Arg Asn 435 440 445 Leu Thr Asn Ala Glu Val Asn Thr Leu Gln Asp Met Val Cys Ser Lys 450 455 460 Leu Val Lys Glu Tyr Ser Val Glu Leu Arg 465 470 <210> 199 Page 280 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 1062 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1062) <400> 199 atg act aca aat aat gac ttc tat ttt gct cta cta cgc ata tct att 48 Met Thr Thr Asn Asn Asp Phe Tyr Phe Ala Leu Leu Arg Ile Ser Ile 1 5 10 15 ctc caa tta ttg aag gca caa gga ttt gac agg gca agg ccc agt ctg 96 Leu Gln Leu Leu Lys Ala Gln Gly Phe Asp Arg Ala Arg Pro Ser Leu 20 25 30 gtg gat gtc atg acc gat ctc tat gca aaa ttc ttg agt ttg tta gca 144 Val Asp Val Met Thr Asp Leu Tyr Ala Lys Phe Leu Ser Leu Leu Ala 35 40 45 tca gag gtc agt tct atc gct cag gca aga tgt gat cag gac gat aca 192 Ser Glu Val Ser Ser Ile Ala Gln Ala Arg Cys Asp Gln Asp Asp Thr 50 55 60 att gct tta caa gat ata act ctg gct ctg gaa aat cta ggt att gtt 240 Ile Ala Leu Gln Asp Ile Thr Leu Ala Leu Glu Asn Leu Gly Ile Val 65 70 75 80 aag cct acg aac gtt ctg gat gtc tat gat gaa aac tcc gaa tta tca 288 Lys Pro Thr Asn Val Leu Asp Val Tyr Asp Glu Asn Ser Glu Leu Ser 85 90 95 agt tca cga gga atg gaa aag ttc aag gac tgg tgt att tat agt act 336 Ser Ser Arg Gly Met Glu Lys Phe Lys Asp Trp Cys Ile Tyr Ser Thr 100 105 110 caa ttg acc gac gcg cga ata act gcc tta ccc aca gta gaa tta cta 384 Gln Leu Thr Asp Ala Arg Ile Thr Ala Leu Pro Thr Val Glu Leu Leu 115 120 125 caa agt gag gaa aaa gaa tct gat cct ttg tca gca ata cct gac tat 432 Gln Ser Glu Glu Lys Glu Ser Asp Pro Leu Ser Ala Ile Pro Asp Tyr 130 135 140 ctc aat caa tta ctg caa aac aag ggt gcg aaa cag aaa tta gaa aca 480 Leu Asn Gln Leu Leu Gln Asn Lys Gly Ala Lys Gln Lys Leu Glu Thr 145 150 155 160 aag aat aga aaa aca gag ttg ata gaa gat cta ata aat aat aat gga 528 Lys Asn Arg Lys Thr Glu Leu Ile Glu Asp Leu Ile Asn Asn Asn Gly 165 170 175 tta gat gat tgg atc aaa tta gtc att gct aga caa cgt ata aac atg 576 Leu Asp Asp Trp Ile Lys Leu Val Ile Ala Arg Gln Arg Ile Asn Met 180 185 190 att gaa aga gct tcc aaa aaa gaa tct caa aat gta ccg gct tta cca 624 Ile Glu Arg Ala Ser Lys Lys Glu Ser Gln Asn Val Pro Ala Leu Pro 195 200 205 cat att gca ggc tat aaa tct tcc att cta agc cgc cat cac cac act 672 His Ile Ala Gly Tyr Lys Ser Ser Ile Leu Ser Arg His His His Thr 210 215 220 acc ata aca aac gaa gat agg atg cct tcg gcg atg acc cca aga gat 720 Thr Ile Thr Asn Glu Asp Arg Met Pro Ser Ala Met Thr Pro Arg Asp Page 281 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 225 230 235 240 gag gat gcc tta aca gag atc caa gaa aat cca ttt gta act agc aaa 768 Glu Asp Ala Leu Thr Glu Ile Gln Glu Asn Pro Phe Val Thr Ser Lys 245 250 255 ctg ccg ata atg aga aaa gaa aat agg tta gaa aat ata act ctt tca 816 Leu Pro Ile Met Arg Lys Glu Asn Arg Leu Glu Asn Ile Thr Leu Ser 260 265 270 ttt gag gat gag gag ctt gaa tca ctt ggc gaa gtg gaa ggc cct aac 864 Phe Glu Asp Glu Glu Leu Glu Ser Leu Gly Glu Val Glu Gly Pro Asn 275 280 285 caa aag tct caa gaa aat aac aat gag gaa agt ttt aaa gag aac aat 912 Gln Lys Ser Gln Glu Asn Asn Asn Glu Glu Ser Phe Lys Glu Asn Asn 290 295 300 aaa agt tta aca gag tct cct cat ggt gat gac cgt gac ata tca atg 960 Lys Ser Leu Thr Glu Ser Pro His Gly Asp Asp Arg Asp Ile Ser Met 305 310 315 320 ttt caa ttc gac tca aat gtt gat act aaa tgg gca gag cag gaa gat 1008 Phe Gln Phe Asp Ser Asn Val Asp Thr Lys Trp Ala Glu Gln Glu Asp 325 330 335 atg gac agc aca ttt caa cgt cga acc tca cta gat tat ggg ggt tac 1056 Met Asp Ser Thr Phe Gln Arg Arg Thr Ser Leu Asp Tyr Gly Gly Tyr 340 345 350 ttt taa 1062 Phe <210> 200 <211> 353 <212> PRT <213> Saccharomyces cerevisiae <400> 200 Met Thr Thr Asn Asn Asp Phe Tyr Phe Ala Leu Leu Arg Ile Ser Ile 1 5 10 15 Leu Gln Leu Leu Lys Ala Gln Gly Phe Asp Arg Ala Arg Pro Ser Leu 20 25 30 Val Asp Val Met Thr Asp Leu Tyr Ala Lys Phe Leu Ser Leu Leu Ala 35 40 45 Ser Glu Val Ser Ser Ile Ala Gln Ala Arg Cys Asp Gln Asp Asp Thr 50 55 60 Ile Ala Leu Gln Asp Ile Thr Leu Ala Leu Glu Asn Leu Gly Ile Val 65 70 75 80 Lys Pro Thr Asn Val Leu Asp Val Tyr Asp Glu Asn Ser Glu Leu Ser 85 90 95 Ser Ser Arg Gly Met Glu Lys Phe Lys Asp Trp Cys Ile Tyr Ser Thr 100 105 110 Page 282 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Leu Thr Asp Ala Arg Ile Thr Ala Leu Pro Thr Val Glu Leu Leu 115 120 125 Gln Ser Glu Glu Lys Glu Ser Asp Pro Leu Ser Ala Ile Pro Asp Tyr 130 135 140 Leu Asn Gln Leu Leu Gln Asn Lys Gly Ala Lys Gln Lys Leu Glu Thr 145 150 155 160 Lys Asn Arg Lys Thr Glu Leu Ile Glu Asp Leu Ile Asn Asn Asn Gly 165 170 175 Leu Asp Asp Trp Ile Lys Leu Val Ile Ala Arg Gln Arg Ile Asn Met 180 185 190 Ile Glu Arg Ala Ser Lys Lys Glu Ser Gln Asn Val Pro Ala Leu Pro 195 200 205 His Ile Ala Gly Tyr Lys Ser Ser Ile Leu Ser Arg His His His Thr 210 215 220 Thr Ile Thr Asn Glu Asp Arg Met Pro Ser Ala Met Thr Pro Arg Asp 225 230 235 240 Glu Asp Ala Leu Thr Glu Ile Gln Glu Asn Pro Phe Val Thr Ser Lys 245 250 255 Leu Pro Ile Met Arg Lys Glu Asn Arg Leu Glu Asn Ile Thr Leu Ser 260 265 270 Phe Glu Asp Glu Glu Leu Glu Ser Leu Gly Glu Val Glu Gly Pro Asn 275 280 285 Gln Lys Ser Gln Glu Asn Asn Asn Glu Glu Ser Phe Lys Glu Asn Asn 290 295 300 Lys Ser Leu Thr Glu Ser Pro His Gly Asp Asp Arg Asp Ile Ser Met 305 310 315 320 Phe Gln Phe Asp Ser Asn Val Asp Thr Lys Trp Ala Glu Gln Glu Asp 325 330 335 Met Asp Ser Thr Phe Gln Arg Arg Thr Ser Leu Asp Tyr Gly Gly Tyr 340 345 350 Phe <210> 201 <211> 1308 Page 283 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1308) <400> 201 atg tct ggt tat ttt tca ggg ttt tct cta aac aag atc acc gat tca 48 Met Ser Gly Tyr Phe Ser Gly Phe Ser Leu Asn Lys Ile Thr Asp Ser 1 5 10 15 att gcc acc gct gct cac aag acc caa gac act ttg aac aat gca tta 96 Ile Ala Thr Ala Ala His Lys Thr Gln Asp Thr Leu Asn Asn Ala Leu 20 25 30 gca aat gca aat gta aac tta aat gac cct caa aca aga cta tca atc 144 Ala Asn Ala Asn Val Asn Leu Asn Asp Pro Gln Thr Arg Leu Ser Ile 35 40 45 aaa tcg cga act aga ttt gtt cag gaa tca ttg ggt act gta tca gat 192 Lys Ser Arg Thr Arg Phe Val Gln Glu Ser Leu Gly Thr Val Ser Asp 50 55 60 ata agt aaa tta cca cca cag tac caa ttc ttg gag aaa aaa agt gat 240 Ile Ser Lys Leu Pro Pro Gln Tyr Gln Phe Leu Glu Lys Lys Ser Asp 65 70 75 80 tcc tta gag aag gta tgt aaa agg att cta ctg gtg tcc aaa acg ttc 288 Ser Leu Glu Lys Val Cys Lys Arg Ile Leu Leu Val Ser Lys Thr Phe 85 90 95 gaa gta gag ggc tac gac tat cca cca aat tta acg gag agt att tcg 336 Glu Val Glu Gly Tyr Asp Tyr Pro Pro Asn Leu Thr Glu Ser Ile Ser 100 105 110 gat tgg tgg tct ctc aat aaa gat ggc tgg ttt ggc tct aaa aaa tcc 384 Asp Trp Trp Ser Leu Asn Lys Asp Gly Trp Phe Gly Ser Lys Lys Ser 115 120 125 gaa agt tcc act aaa aaa aag gga tct aac cat gac gat gct ttt ttg 432 Glu Ser Ser Thr Lys Lys Lys Gly Ser Asn His Asp Asp Ala Phe Leu 130 135 140 cca agg tct ttt gct caa gcc atc tca aaa gcc gct gtt gac tgc gaa 480 Pro Arg Ser Phe Ala Gln Ala Ile Ser Lys Ala Ala Val Asp Cys Glu 145 150 155 160 tgt gaa ttt caa aat tta gaa cac aac gaa aag gca gaa cta aag aag 528 Cys Glu Phe Gln Asn Leu Glu His Asn Glu Lys Ala Glu Leu Lys Lys 165 170 175 aaa aag gag tct atc aaa act gca cag aca acg gaa gct cag ggt gcc 576 Lys Lys Glu Ser Ile Lys Thr Ala Gln Thr Thr Glu Ala Gln Gly Ala 180 185 190 gac cat aat gaa gaa gac gag gaa gat gaa gaa gat gaa gaa gat gat 624 Asp His Asn Glu Glu Asp Glu Glu Asp Glu Glu Asp Glu Glu Asp Asp 195 200 205 gaa gat ttg tct aat ttg atc aaa gtt ttc gat tcg tgg tcg aca tgc 672 Glu Asp Leu Ser Asn Leu Ile Lys Val Phe Asp Ser Trp Ser Thr Cys 210 215 220 tat aaa aat atc gat gaa ggg aag gca gag atg gat tct atg atg gtc 720 Tyr Lys Asn Ile Asp Glu Gly Lys Ala Glu Met Asp Ser Met Met Val 225 230 235 240 Page 284 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag gaa ttc aac aaa aaa tta gaa aca tta ata aac caa gac ttc aag 768 Lys Glu Phe Asn Lys Lys Leu Glu Thr Leu Ile Asn Gln Asp Phe Lys 245 250 255 aag gtc cat gac ctg cgc aaa aaa gtg gaa gaa tca aga ctc aaa ttt 816 Lys Val His Asp Leu Arg Lys Lys Val Glu Glu Ser Arg Leu Lys Phe 260 265 270 gat aca atg cgt tat gaa gtc aaa gca aaa gaa gca gag tta gag gcg 864 Asp Thr Met Arg Tyr Glu Val Lys Ala Lys Glu Ala Glu Leu Glu Ala 275 280 285 aaa aaa gct gaa gcc aca gga gaa gca cat agc aag gat gtt agc gca 912 Lys Lys Ala Glu Ala Thr Gly Glu Ala His Ser Lys Asp Val Ser Ala 290 295 300 aag gac att agc gca aac act acc acc tct ttt gac gaa acg cct tct 960 Lys Asp Ile Ser Ala Asn Thr Thr Thr Ser Phe Asp Glu Thr Pro Ser 305 310 315 320 acc gag gat gaa aag cca aaa tca gag ggt gcc gaa gag gaa tca aag 1008 Thr Glu Asp Glu Lys Pro Lys Ser Glu Gly Ala Glu Glu Glu Ser Lys 325 330 335 aaa gaa gcg aat gag cct act gtt gat gac gtt gct gat aga aaa gaa 1056 Lys Glu Ala Asn Glu Pro Thr Val Asp Asp Val Ala Asp Arg Lys Glu 340 345 350 gat tta aag agt aac aaa gta aat gat gag cca ccg att gaa gaa tct 1104 Asp Leu Lys Ser Asn Lys Val Asn Asp Glu Pro Pro Ile Glu Glu Ser 355 360 365 gag gat aat aaa tta ctg gaa aaa ctg gag gat gaa ttt gtc tcc aat 1152 Glu Asp Asn Lys Leu Leu Glu Lys Leu Glu Asp Glu Phe Val Ser Asn 370 375 380 act aca gca gca gtg gaa aca atg gaa gaa atc act gac agt tct gaa 1200 Thr Thr Ala Ala Val Glu Thr Met Glu Glu Ile Thr Asp Ser Ser Glu 385 390 395 400 att ctg ggc ttg ata aaa ctg ttc cag aat ttc cag ttg gtt tac ttt 1248 Ile Leu Gly Leu Ile Lys Leu Phe Gln Asn Phe Gln Leu Val Tyr Phe 405 410 415 aga caa tgt gtc caa gaa gtg gag gca aac ctt aaa gtt cta aat ggt 1296 Arg Gln Cys Val Gln Glu Val Glu Ala Asn Leu Lys Val Leu Asn Gly 420 425 430 ttg gaa att tag 1308 Leu Glu Ile 435 <210> 202 <211> 435 <212> PRT <213> Saccharomyces cerevisiae <400> 202 Met Ser Gly Tyr Phe Ser Gly Phe Ser Leu Asn Lys Ile Thr Asp Ser 1 5 10 15 Ile Ala Thr Ala Ala His Lys Thr Gln Asp Thr Leu Asn Asn Ala Leu 20 25 30 Page 285 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Asn Ala Asn Val Asn Leu Asn Asp Pro Gln Thr Arg Leu Ser Ile 35 40 45 Lys Ser Arg Thr Arg Phe Val Gln Glu Ser Leu Gly Thr Val Ser Asp 50 55 60 Ile Ser Lys Leu Pro Pro Gln Tyr Gln Phe Leu Glu Lys Lys Ser Asp 65 70 75 80 Ser Leu Glu Lys Val Cys Lys Arg Ile Leu Leu Val Ser Lys Thr Phe 85 90 95 Glu Val Glu Gly Tyr Asp Tyr Pro Pro Asn Leu Thr Glu Ser Ile Ser 100 105 110 Asp Trp Trp Ser Leu Asn Lys Asp Gly Trp Phe Gly Ser Lys Lys Ser 115 120 125 Glu Ser Ser Thr Lys Lys Lys Gly Ser Asn His Asp Asp Ala Phe Leu 130 135 140 Pro Arg Ser Phe Ala Gln Ala Ile Ser Lys Ala Ala Val Asp Cys Glu 145 150 155 160 Cys Glu Phe Gln Asn Leu Glu His Asn Glu Lys Ala Glu Leu Lys Lys 165 170 175 Lys Lys Glu Ser Ile Lys Thr Ala Gln Thr Thr Glu Ala Gln Gly Ala 180 185 190 Asp His Asn Glu Glu Asp Glu Glu Asp Glu Glu Asp Glu Glu Asp Asp 195 200 205 Glu Asp Leu Ser Asn Leu Ile Lys Val Phe Asp Ser Trp Ser Thr Cys 210 215 220 Tyr Lys Asn Ile Asp Glu Gly Lys Ala Glu Met Asp Ser Met Met Val 225 230 235 240 Lys Glu Phe Asn Lys Lys Leu Glu Thr Leu Ile Asn Gln Asp Phe Lys 245 250 255 Lys Val His Asp Leu Arg Lys Lys Val Glu Glu Ser Arg Leu Lys Phe 260 265 270 Asp Thr Met Arg Tyr Glu Val Lys Ala Lys Glu Ala Glu Leu Glu Ala 275 280 285 Lys Lys Ala Glu Ala Thr Gly Glu Ala His Ser Lys Asp Val Ser Ala 290 295 300 Page 286 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Asp Ile Ser Ala Asn Thr Thr Thr Ser Phe Asp Glu Thr Pro Ser 305 310 315 320 Thr Glu Asp Glu Lys Pro Lys Ser Glu Gly Ala Glu Glu Glu Ser Lys 325 330 335 Lys Glu Ala Asn Glu Pro Thr Val Asp Asp Val Ala Asp Arg Lys Glu 340 345 350 Asp Leu Lys Ser Asn Lys Val Asn Asp Glu Pro Pro Ile Glu Glu Ser 355 360 365 Glu Asp Asn Lys Leu Leu Glu Lys Leu Glu Asp Glu Phe Val Ser Asn 370 375 380 Thr Thr Ala Ala Val Glu Thr Met Glu Glu Ile Thr Asp Ser Ser Glu 385 390 395 400 Ile Leu Gly Leu Ile Lys Leu Phe Gln Asn Phe Gln Leu Val Tyr Phe 405 410 415 Arg Gln Cys Val Gln Glu Val Glu Ala Asn Leu Lys Val Leu Asn Gly 420 425 430 Leu Glu Ile 435 <210> 203 <211> 1839 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1839) <400> 203 atg gct gaa atg aag aat tcg aca gct gct agt tcc aga tgg acg aag 48 Met Ala Glu Met Lys Asn Ser Thr Ala Ala Ser Ser Arg Trp Thr Lys 1 5 10 15 agt cgt ctc tcc cat ttc ttt ccc tcg tac act aat agc agt ggt atg 96 Ser Arg Leu Ser His Phe Phe Pro Ser Tyr Thr Asn Ser Ser Gly Met 20 25 30 ggg gcc gcc tca act gat caa tct tct acg cag gga gaa gaa ctg cac 144 Gly Ala Ala Ser Thr Asp Gln Ser Ser Thr Gln Gly Glu Glu Leu His 35 40 45 cat agg aag cac tgt gaa gaa gac aat gat ggt caa aaa ccg aaa aag 192 His Arg Lys His Cys Glu Glu Asp Asn Asp Gly Gln Lys Pro Lys Lys 50 55 60 tct ccc gta tcc acc tct aca atg caa ata aaa tct aga cag gat gag 240 Ser Pro Val Ser Thr Ser Thr Met Gln Ile Lys Ser Arg Gln Asp Glu 65 70 75 80 Page 287 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gac gag gat gac ggt cga att gtc att aaa cca gtt aac gat gaa gat 288 Asp Glu Asp Asp Gly Arg Ile Val Ile Lys Pro Val Asn Asp Glu Asp 85 90 95 gat aca tca gtg att ata act ttc aat cag tca ata tcc cct ttt att 336 Asp Thr Ser Val Ile Ile Thr Phe Asn Gln Ser Ile Ser Pro Phe Ile 100 105 110 att aca ttg aca ttc gtt gcg tcc att tct ggg ttc atg ttt ggt tat 384 Ile Thr Leu Thr Phe Val Ala Ser Ile Ser Gly Phe Met Phe Gly Tyr 115 120 125 gat act ggt tac ata tcg agt gcg cta att tct atc aat aga gat tta 432 Asp Thr Gly Tyr Ile Ser Ser Ala Leu Ile Ser Ile Asn Arg Asp Leu 130 135 140 gac aac aaa gtt tta act tat gga gaa aaa gaa tta att acg gcc gcc 480 Asp Asn Lys Val Leu Thr Tyr Gly Glu Lys Glu Leu Ile Thr Ala Ala 145 150 155 160 aca tca ttg ggc gct ttg att aca agt gtg ggc gct ggt act gct gct 528 Thr Ser Leu Gly Ala Leu Ile Thr Ser Val Gly Ala Gly Thr Ala Ala 165 170 175 gat gtg ttt gga aga aga cca tgt tta atg ttc tcc aat ctg atg ttt 576 Asp Val Phe Gly Arg Arg Pro Cys Leu Met Phe Ser Asn Leu Met Phe 180 185 190 ttg atc gga gca att tta caa att acc gcg cac aag ttt tgg caa atg 624 Leu Ile Gly Ala Ile Leu Gln Ile Thr Ala His Lys Phe Trp Gln Met 195 200 205 gcg gcc ggt aga ctg att atg ggt ttc ggt gtc ggt att ggt tct ttg 672 Ala Ala Gly Arg Leu Ile Met Gly Phe Gly Val Gly Ile Gly Ser Leu 210 215 220 att tct cct ctt ttt att agt gaa att gct cct aag atg atc agg ggt 720 Ile Ser Pro Leu Phe Ile Ser Glu Ile Ala Pro Lys Met Ile Arg Gly 225 230 235 240 agg tta acc gtt ata aat tcc cta tgg ctg aca ggt ggt caa ttg att 768 Arg Leu Thr Val Ile Asn Ser Leu Trp Leu Thr Gly Gly Gln Leu Ile 245 250 255 gct tac ggt tgt ggt gcg ggc ctg aac cac gtc aaa aac ggt tgg aga 816 Ala Tyr Gly Cys Gly Ala Gly Leu Asn His Val Lys Asn Gly Trp Arg 260 265 270 atc tta gtt ggt ttg tcc ttg ata cct act gtt ttg cag ttt tct ttt 864 Ile Leu Val Gly Leu Ser Leu Ile Pro Thr Val Leu Gln Phe Ser Phe 275 280 285 ttc tgt ttt ttg ccg gat aca cca aga tac tac gta atg aaa ggc gat 912 Phe Cys Phe Leu Pro Asp Thr Pro Arg Tyr Tyr Val Met Lys Gly Asp 290 295 300 tta aag aga gca aaa atg gtt ctc aaa cga agt tac gta aac act gaa 960 Leu Lys Arg Ala Lys Met Val Leu Lys Arg Ser Tyr Val Asn Thr Glu 305 310 315 320 gat gaa ata att gat caa aaa gtt gaa gaa tta tct agc tta aat caa 1008 Asp Glu Ile Ile Asp Gln Lys Val Glu Glu Leu Ser Ser Leu Asn Gln 325 330 335 tcg ata cca gga aaa aat cca ata aca aaa ttc tgg aat atg gtc aag 1056 Ser Ile Pro Gly Lys Asn Pro Ile Thr Lys Phe Trp Asn Met Val Lys 340 345 350 Page 288 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa ttg cac act gtg cct tca aat ttc aga gct ttg att att ggt tgt 1104 Glu Leu His Thr Val Pro Ser Asn Phe Arg Ala Leu Ile Ile Gly Cys 355 360 365 ggt cta caa gcc att caa caa ttc aca ggt tgg aat tcc tta atg tat 1152 Gly Leu Gln Ala Ile Gln Gln Phe Thr Gly Trp Asn Ser Leu Met Tyr 370 375 380 ttc tcc ggt aca ata ttt gaa act gtt gga ttc aaa aat tct tct gcc 1200 Phe Ser Gly Thr Ile Phe Glu Thr Val Gly Phe Lys Asn Ser Ser Ala 385 390 395 400 gtt tct att att gtc tca ggt act aat ttt gtg ttc aca tta ata gca 1248 Val Ser Ile Ile Val Ser Gly Thr Asn Phe Val Phe Thr Leu Ile Ala 405 410 415 ttt ttc tgt att gat aaa atc ggc cgt agg tac att tta ctg att gga 1296 Phe Phe Cys Ile Asp Lys Ile Gly Arg Arg Tyr Ile Leu Leu Ile Gly 420 425 430 cta cct ggt atg act gtg gcg ctg gtt ata tgt gct ata gcg ttc cat 1344 Leu Pro Gly Met Thr Val Ala Leu Val Ile Cys Ala Ile Ala Phe His 435 440 445 ttc cta ggt att aag ttt aac ggt gct gat gca gta gtg gca tct gat 1392 Phe Leu Gly Ile Lys Phe Asn Gly Ala Asp Ala Val Val Ala Ser Asp 450 455 460 gga ttt tca tct tgg ggc att gtc att atc gta ttt att att gtg tat 1440 Gly Phe Ser Ser Trp Gly Ile Val Ile Ile Val Phe Ile Ile Val Tyr 465 470 475 480 gca gcc ttt tat gcc ctc ggt atc ggc act gtt cca tgg caa caa tcg 1488 Ala Ala Phe Tyr Ala Leu Gly Ile Gly Thr Val Pro Trp Gln Gln Ser 485 490 495 gaa tta ttt cca caa aac gtc aga ggt gta ggg aca tcc tac gct act 1536 Glu Leu Phe Pro Gln Asn Val Arg Gly Val Gly Thr Ser Tyr Ala Thr 500 505 510 gcc acc aat tgg gca ggt tct tta gtc att gcg tct acg ttc ttg act 1584 Ala Thr Asn Trp Ala Gly Ser Leu Val Ile Ala Ser Thr Phe Leu Thr 515 520 525 atg tta caa aat att aca cca acg ggt aca ttt tca ttc ttt gcc ggt 1632 Met Leu Gln Asn Ile Thr Pro Thr Gly Thr Phe Ser Phe Phe Ala Gly 530 535 540 gta gca tgt tta tca acc att ttt tgt tac ttt tgt tat cca gaa cta 1680 Val Ala Cys Leu Ser Thr Ile Phe Cys Tyr Phe Cys Tyr Pro Glu Leu 545 550 555 560 tca gga ttg gag tta gag gaa gtt caa aca att tta aag gac gga ttc 1728 Ser Gly Leu Glu Leu Glu Glu Val Gln Thr Ile Leu Lys Asp Gly Phe 565 570 575 aat atc aaa gcc tct aaa gct cta gct aaa aag agg aaa caa cag gtg 1776 Asn Ile Lys Ala Ser Lys Ala Leu Ala Lys Lys Arg Lys Gln Gln Val 580 585 590 gcc gaa ggt gct gcc cat cat aaa ctc aaa ttc gaa cct aca cag gaa 1824 Ala Glu Gly Ala Ala His His Lys Leu Lys Phe Glu Pro Thr Gln Glu 595 600 605 att gta gaa agt tag 1839 Ile Val Glu Ser 610 Page 289 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 204 <211> 612 <212> PRT <213> Saccharomyces cerevisiae <400> 204 Met Ala Glu Met Lys Asn Ser Thr Ala Ala Ser Ser Arg Trp Thr Lys 1 5 10 15 Ser Arg Leu Ser His Phe Phe Pro Ser Tyr Thr Asn Ser Ser Gly Met 20 25 30 Gly Ala Ala Ser Thr Asp Gln Ser Ser Thr Gln Gly Glu Glu Leu His 35 40 45 His Arg Lys His Cys Glu Glu Asp Asn Asp Gly Gln Lys Pro Lys Lys 50 55 60 Ser Pro Val Ser Thr Ser Thr Met Gln Ile Lys Ser Arg Gln Asp Glu 65 70 75 80 Asp Glu Asp Asp Gly Arg Ile Val Ile Lys Pro Val Asn Asp Glu Asp 85 90 95 Asp Thr Ser Val Ile Ile Thr Phe Asn Gln Ser Ile Ser Pro Phe Ile 100 105 110 Ile Thr Leu Thr Phe Val Ala Ser Ile Ser Gly Phe Met Phe Gly Tyr 115 120 125 Asp Thr Gly Tyr Ile Ser Ser Ala Leu Ile Ser Ile Asn Arg Asp Leu 130 135 140 Asp Asn Lys Val Leu Thr Tyr Gly Glu Lys Glu Leu Ile Thr Ala Ala 145 150 155 160 Thr Ser Leu Gly Ala Leu Ile Thr Ser Val Gly Ala Gly Thr Ala Ala 165 170 175 Asp Val Phe Gly Arg Arg Pro Cys Leu Met Phe Ser Asn Leu Met Phe 180 185 190 Leu Ile Gly Ala Ile Leu Gln Ile Thr Ala His Lys Phe Trp Gln Met 195 200 205 Ala Ala Gly Arg Leu Ile Met Gly Phe Gly Val Gly Ile Gly Ser Leu 210 215 220 Ile Ser Pro Leu Phe Ile Ser Glu Ile Ala Pro Lys Met Ile Arg Gly 225 230 235 240 Page 290 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Leu Thr Val Ile Asn Ser Leu Trp Leu Thr Gly Gly Gln Leu Ile 245 250 255 Ala Tyr Gly Cys Gly Ala Gly Leu Asn His Val Lys Asn Gly Trp Arg 260 265 270 Ile Leu Val Gly Leu Ser Leu Ile Pro Thr Val Leu Gln Phe Ser Phe 275 280 285 Phe Cys Phe Leu Pro Asp Thr Pro Arg Tyr Tyr Val Met Lys Gly Asp 290 295 300 Leu Lys Arg Ala Lys Met Val Leu Lys Arg Ser Tyr Val Asn Thr Glu 305 310 315 320 Asp Glu Ile Ile Asp Gln Lys Val Glu Glu Leu Ser Ser Leu Asn Gln 325 330 335 Ser Ile Pro Gly Lys Asn Pro Ile Thr Lys Phe Trp Asn Met Val Lys 340 345 350 Glu Leu His Thr Val Pro Ser Asn Phe Arg Ala Leu Ile Ile Gly Cys 355 360 365 Gly Leu Gln Ala Ile Gln Gln Phe Thr Gly Trp Asn Ser Leu Met Tyr 370 375 380 Phe Ser Gly Thr Ile Phe Glu Thr Val Gly Phe Lys Asn Ser Ser Ala 385 390 395 400 Val Ser Ile Ile Val Ser Gly Thr Asn Phe Val Phe Thr Leu Ile Ala 405 410 415 Phe Phe Cys Ile Asp Lys Ile Gly Arg Arg Tyr Ile Leu Leu Ile Gly 420 425 430 Leu Pro Gly Met Thr Val Ala Leu Val Ile Cys Ala Ile Ala Phe His 435 440 445 Phe Leu Gly Ile Lys Phe Asn Gly Ala Asp Ala Val Val Ala Ser Asp 450 455 460 Gly Phe Ser Ser Trp Gly Ile Val Ile Ile Val Phe Ile Ile Val Tyr 465 470 475 480 Ala Ala Phe Tyr Ala Leu Gly Ile Gly Thr Val Pro Trp Gln Gln Ser 485 490 495 Glu Leu Phe Pro Gln Asn Val Arg Gly Val Gly Thr Ser Tyr Ala Thr 500 505 510 Page 291 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Thr Asn Trp Ala Gly Ser Leu Val Ile Ala Ser Thr Phe Leu Thr 515 520 525 Met Leu Gln Asn Ile Thr Pro Thr Gly Thr Phe Ser Phe Phe Ala Gly 530 535 540 Val Ala Cys Leu Ser Thr Ile Phe Cys Tyr Phe Cys Tyr Pro Glu Leu 545 550 555 560 Ser Gly Leu Glu Leu Glu Glu Val Gln Thr Ile Leu Lys Asp Gly Phe 565 570 575 Asn Ile Lys Ala Ser Lys Ala Leu Ala Lys Lys Arg Lys Gln Gln Val 580 585 590 Ala Glu Gly Ala Ala His His Lys Leu Lys Phe Glu Pro Thr Gln Glu 595 600 605 Ile Val Glu Ser 610 <210> 205 <211> 624 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(624) <400> 205 atg cgc gtt ttt act ttg att gcg att ttg ttt agt tca tct ttg tta 48 Met Arg Val Phe Thr Leu Ile Ala Ile Leu Phe Ser Ser Ser Leu Leu 1 5 10 15 aca cat gca ttc tcc tct aat tat gct cct gta ggc ata tca tta cct 96 Thr His Ala Phe Ser Ser Asn Tyr Ala Pro Val Gly Ile Ser Leu Pro 20 25 30 gct ttt acc aaa gaa tgt ctt tac tat gat tta tcc tct gat aaa gat 144 Ala Phe Thr Lys Glu Cys Leu Tyr Tyr Asp Leu Ser Ser Asp Lys Asp 35 40 45 gtc ctt gtg gtc agt tac caa gtt ttg aca ggt ggg aat ttc gag ata 192 Val Leu Val Val Ser Tyr Gln Val Leu Thr Gly Gly Asn Phe Glu Ile 50 55 60 gac ttc gat att acc gcc cct gat ggc tct gtt atc gtc act gaa aga 240 Asp Phe Asp Ile Thr Ala Pro Asp Gly Ser Val Ile Val Thr Glu Arg 65 70 75 80 caa aag aag cat tct gat ttt cta ctg aag tcg ttt ggt ata ggt aag 288 Gln Lys Lys His Ser Asp Phe Leu Leu Lys Ser Phe Gly Ile Gly Lys 85 90 95 tac act ttc tgt ttg agt aat aac tac ggc act tcc cca aag aaa gtt 336 Tyr Thr Phe Cys Leu Ser Asn Asn Tyr Gly Thr Ser Pro Lys Lys Val 100 105 110 gaa atc acc ctc gaa aag gaa aag gaa att gtt tct tcc cat gaa agc 384 Page 292 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Ile Thr Leu Glu Lys Glu Lys Glu Ile Val Ser Ser His Glu Ser 115 120 125 aaa gag gac ata atc gca aac aac gcc atc gag gaa att gat agg aac 432 Lys Glu Asp Ile Ile Ala Asn Asn Ala Ile Glu Glu Ile Asp Arg Asn 130 135 140 ctg aat aag atc acc aaa aca atg gat tat tta agg gct aga gaa tgg 480 Leu Asn Lys Ile Thr Lys Thr Met Asp Tyr Leu Arg Ala Arg Glu Trp 145 150 155 160 aga aac atg tat act gtg agt tct act gag tca aga tta aca tgg ctc 528 Arg Asn Met Tyr Thr Val Ser Ser Thr Glu Ser Arg Leu Thr Trp Leu 165 170 175 tca tta cta att atg ggg gta atg gtt ggt atc agt ata gtg cag gca 576 Ser Leu Leu Ile Met Gly Val Met Val Gly Ile Ser Ile Val Gln Ala 180 185 190 tta att att cag ttc ttt ttt acc agt cgc caa aaa aac tac gta tag 624 Leu Ile Ile Gln Phe Phe Phe Thr Ser Arg Gln Lys Asn Tyr Val 195 200 205 <210> 206 <211> 207 <212> PRT <213> Saccharomyces cerevisiae <400> 206 Met Arg Val Phe Thr Leu Ile Ala Ile Leu Phe Ser Ser Ser Leu Leu 1 5 10 15 Thr His Ala Phe Ser Ser Asn Tyr Ala Pro Val Gly Ile Ser Leu Pro 20 25 30 Ala Phe Thr Lys Glu Cys Leu Tyr Tyr Asp Leu Ser Ser Asp Lys Asp 35 40 45 Val Leu Val Val Ser Tyr Gln Val Leu Thr Gly Gly Asn Phe Glu Ile 50 55 60 Asp Phe Asp Ile Thr Ala Pro Asp Gly Ser Val Ile Val Thr Glu Arg 65 70 75 80 Gln Lys Lys His Ser Asp Phe Leu Leu Lys Ser Phe Gly Ile Gly Lys 85 90 95 Tyr Thr Phe Cys Leu Ser Asn Asn Tyr Gly Thr Ser Pro Lys Lys Val 100 105 110 Glu Ile Thr Leu Glu Lys Glu Lys Glu Ile Val Ser Ser His Glu Ser 115 120 125 Lys Glu Asp Ile Ile Ala Asn Asn Ala Ile Glu Glu Ile Asp Arg Asn 130 135 140 Leu Asn Lys Ile Thr Lys Thr Met Asp Tyr Leu Arg Ala Arg Glu Trp Page 293 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 Arg Asn Met Tyr Thr Val Ser Ser Thr Glu Ser Arg Leu Thr Trp Leu 165 170 175 Ser Leu Leu Ile Met Gly Val Met Val Gly Ile Ser Ile Val Gln Ala 180 185 190 Leu Ile Ile Gln Phe Phe Phe Thr Ser Arg Gln Lys Asn Tyr Val 195 200 205 <210> 207 <211> 483 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(483) <400> 207 atg ggt aaa tca cat ggt tac aga tct cgt aca cgt tac atg ttc caa 48 Met Gly Lys Ser His Gly Tyr Arg Ser Arg Thr Arg Tyr Met Phe Gln 1 5 10 15 cgt gac ttc aga aag cat ggt gcc gtt cac atg tcc acc tac ttg aag 96 Arg Asp Phe Arg Lys His Gly Ala Val His Met Ser Thr Tyr Leu Lys 20 25 30 atc tac aag gtt ggt gac att gtc gac atc aaa gcc aat ggt tct atc 144 Ile Tyr Lys Val Gly Asp Ile Val Asp Ile Lys Ala Asn Gly Ser Ile 35 40 45 caa aag ggt atg cca cac aag ttc tac caa ggt aag acc ggt gtc gtc 192 Gln Lys Gly Met Pro His Lys Phe Tyr Gln Gly Lys Thr Gly Val Val 50 55 60 tac aac gtt acc aag tct tct gtt ggt gtt atc atc aac aag atg gtc 240 Tyr Asn Val Thr Lys Ser Ser Val Gly Val Ile Ile Asn Lys Met Val 65 70 75 80 ggt aac aga tac ttg gaa aag aga ttg aac ttg aga gtt gaa cac atc 288 Gly Asn Arg Tyr Leu Glu Lys Arg Leu Asn Leu Arg Val Glu His Ile 85 90 95 aag cac tct aaa tgt aga caa gaa ttt ttg gaa aga gtt aag gcc aat 336 Lys His Ser Lys Cys Arg Gln Glu Phe Leu Glu Arg Val Lys Ala Asn 100 105 110 gct gct aag cgt gct gaa gcc aag gcc caa ggt gtt gct gtc caa ttg 384 Ala Ala Lys Arg Ala Glu Ala Lys Ala Gln Gly Val Ala Val Gln Leu 115 120 125 aag aga caa cca gct caa cca aga gaa tcc cgt att gtc tct act gaa 432 Lys Arg Gln Pro Ala Gln Pro Arg Glu Ser Arg Ile Val Ser Thr Glu 130 135 140 ggt aac gtt cct caa act tta gct cca gtt cca tac gaa acc ttc att 480 Gly Asn Val Pro Gln Thr Leu Ala Pro Val Pro Tyr Glu Thr Phe Ile 145 150 155 160 taa 483 Page 294 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 208 <211> 160 <212> PRT <213> Saccharomyces cerevisiae <400> 208 Met Gly Lys Ser His Gly Tyr Arg Ser Arg Thr Arg Tyr Met Phe Gln 1 5 10 15 Arg Asp Phe Arg Lys His Gly Ala Val His Met Ser Thr Tyr Leu Lys 20 25 30 Ile Tyr Lys Val Gly Asp Ile Val Asp Ile Lys Ala Asn Gly Ser Ile 35 40 45 Gln Lys Gly Met Pro His Lys Phe Tyr Gln Gly Lys Thr Gly Val Val 50 55 60 Tyr Asn Val Thr Lys Ser Ser Val Gly Val Ile Ile Asn Lys Met Val 65 70 75 80 Gly Asn Arg Tyr Leu Glu Lys Arg Leu Asn Leu Arg Val Glu His Ile 85 90 95 Lys His Ser Lys Cys Arg Gln Glu Phe Leu Glu Arg Val Lys Ala Asn 100 105 110 Ala Ala Lys Arg Ala Glu Ala Lys Ala Gln Gly Val Ala Val Gln Leu 115 120 125 Lys Arg Gln Pro Ala Gln Pro Arg Glu Ser Arg Ile Val Ser Thr Glu 130 135 140 Gly Asn Val Pro Gln Thr Leu Ala Pro Val Pro Tyr Glu Thr Phe Ile 145 150 155 160 <210> 209 <211> 1737 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1737) <400> 209 atg tca att cag gct ttt gtc ttt tgc ggt aaa ggt tcc aat ttg gct 48 Met Ser Ile Gln Ala Phe Val Phe Cys Gly Lys Gly Ser Asn Leu Ala 1 5 10 15 ccc ttc acc cag cca gat ttt cca ttc caa acg cag aac aaa gac agt 96 Pro Phe Thr Gln Pro Asp Phe Pro Phe Gln Thr Gln Asn Lys Asp Ser 20 25 30 aca gct gcc acg agc ggt gac aaa ctt aat gag ttg gtc aat agc gcc 144 Page 295 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Ala Ala Thr Ser Gly Asp Lys Leu Asn Glu Leu Val Asn Ser Ala 35 40 45 ctc gat tca act gtc ata aat gag ttc atg caa cat tca acg cgc ttg 192 Leu Asp Ser Thr Val Ile Asn Glu Phe Met Gln His Ser Thr Arg Leu 50 55 60 ccc aag gct ctt ttg ccc atc ggt aat aga cct atg att gaa tac gtc 240 Pro Lys Ala Leu Leu Pro Ile Gly Asn Arg Pro Met Ile Glu Tyr Val 65 70 75 80 ttg gat tgg tgt gat cag gca gat ttc aaa gaa atc agt gtg gtc gca 288 Leu Asp Trp Cys Asp Gln Ala Asp Phe Lys Glu Ile Ser Val Val Ala 85 90 95 ccc gtt gac gaa atc gaa tta att gaa agt gga ctg act tcg ttt ttg 336 Pro Val Asp Glu Ile Glu Leu Ile Glu Ser Gly Leu Thr Ser Phe Leu 100 105 110 tcc cta aga aag caa caa ttt gaa cta ata tac aag gct ttg tca aat 384 Ser Leu Arg Lys Gln Gln Phe Glu Leu Ile Tyr Lys Ala Leu Ser Asn 115 120 125 tcc aac cac agt cat cac ttg caa gat cct aag aaa att aat ttc atc 432 Ser Asn His Ser His His Leu Gln Asp Pro Lys Lys Ile Asn Phe Ile 130 135 140 cct tcg aag gca aat tct aca ggt gag tcc ttg caa aaa gag ctt ttg 480 Pro Ser Lys Ala Asn Ser Thr Gly Glu Ser Leu Gln Lys Glu Leu Leu 145 150 155 160 cct aga atc aat ggc gat ttt gta atc ttg ccc tgt gat ttt gtc aca 528 Pro Arg Ile Asn Gly Asp Phe Val Ile Leu Pro Cys Asp Phe Val Thr 165 170 175 gat ata cct cca caa gtc ttg gtc gat caa ttt agg aat agg gat gat 576 Asp Ile Pro Pro Gln Val Leu Val Asp Gln Phe Arg Asn Arg Asp Asp 180 185 190 aat aac cta gca atg act atc tac tat aag aac tct tta gat agt agt 624 Asn Asn Leu Ala Met Thr Ile Tyr Tyr Lys Asn Ser Leu Asp Ser Ser 195 200 205 atc gat aaa aag caa cag caa aag caa aaa caa cag caa ttt ttc act 672 Ile Asp Lys Lys Gln Gln Gln Lys Gln Lys Gln Gln Gln Phe Phe Thr 210 215 220 gtt tat tca gaa aac gaa gac tca gag agg cag cca ata ctt ttg gac 720 Val Tyr Ser Glu Asn Glu Asp Ser Glu Arg Gln Pro Ile Leu Leu Asp 225 230 235 240 gtt tat tct caa agg gac gtc aca aag aca aaa tat cta cag atc aga 768 Val Tyr Ser Gln Arg Asp Val Thr Lys Thr Lys Tyr Leu Gln Ile Arg 245 250 255 tct cat tta tta tgg aac tat cca aat tta aca gta tcc act aag tta 816 Ser His Leu Leu Trp Asn Tyr Pro Asn Leu Thr Val Ser Thr Lys Leu 260 265 270 ctg aac tca ttc atc tac ttt tgt tcc ttt gaa ctt tgc cag ttg tta 864 Leu Asn Ser Phe Ile Tyr Phe Cys Ser Phe Glu Leu Cys Gln Leu Leu 275 280 285 aaa tta gga cct caa tca atg tca aga caa gct tca ttc aaa gat cca 912 Lys Leu Gly Pro Gln Ser Met Ser Arg Gln Ala Ser Phe Lys Asp Pro 290 295 300 ttt act gga aac caa caa cag caa aac cct cct act act gat gat gat 960 Page 296 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Thr Gly Asn Gln Gln Gln Gln Asn Pro Pro Thr Thr Asp Asp Asp 305 310 315 320 gaa gat cgc aat cat gat gat gac gat gat tac aaa cct tcg gct aca 1008 Glu Asp Arg Asn His Asp Asp Asp Asp Asp Tyr Lys Pro Ser Ala Thr 325 330 335 tct atc cag cct acc tac ttc aaa aaa aag aat gat ctc atc ttg gac 1056 Ser Ile Gln Pro Thr Tyr Phe Lys Lys Lys Asn Asp Leu Ile Leu Asp 340 345 350 cca ata aac tgt aat aaa tca ttg agt aag gtt ttt aga gat tta tct 1104 Pro Ile Asn Cys Asn Lys Ser Leu Ser Lys Val Phe Arg Asp Leu Ser 355 360 365 cgt cgt tcg tgg caa cat tcg aaa ccg agg gaa cca ata ggt att ttt 1152 Arg Arg Ser Trp Gln His Ser Lys Pro Arg Glu Pro Ile Gly Ile Phe 370 375 380 att tta cca aac gaa acc ttg ttc atc aga gcc aat aac ttg aat gct 1200 Ile Leu Pro Asn Glu Thr Leu Phe Ile Arg Ala Asn Asn Leu Asn Ala 385 390 395 400 tac atg gac gct aat aga ttt gta cta aag ata aaa tca caa acg atg 1248 Tyr Met Asp Ala Asn Arg Phe Val Leu Lys Ile Lys Ser Gln Thr Met 405 410 415 ttc acg aaa aat ata cag att caa tct gcc gct atc ggt gct gat gcc 1296 Phe Thr Lys Asn Ile Gln Ile Gln Ser Ala Ala Ile Gly Ala Asp Ala 420 425 430 ata gta gat ccc aaa tgc caa atc tct gct cat agt aat gtc aag atg 1344 Ile Val Asp Pro Lys Cys Gln Ile Ser Ala His Ser Asn Val Lys Met 435 440 445 tct gtt ctc ggt act cag gcc aat att ggt tcc aga tgt cgt gtt gca 1392 Ser Val Leu Gly Thr Gln Ala Asn Ile Gly Ser Arg Cys Arg Val Ala 450 455 460 ggg tct ctc tta ttt cct gga gtc cat ctt ggt gac gaa gta atc ctg 1440 Gly Ser Leu Leu Phe Pro Gly Val His Leu Gly Asp Glu Val Ile Leu 465 470 475 480 gaa aat tgt att att gga cct atg gca aaa atc ggt tca aag tgt aaa 1488 Glu Asn Cys Ile Ile Gly Pro Met Ala Lys Ile Gly Ser Lys Cys Lys 485 490 495 ctc agc aat tgt tat atc gaa ggc cat tat gtt gtg gag cct aaa aat 1536 Leu Ser Asn Cys Tyr Ile Glu Gly His Tyr Val Val Glu Pro Lys Asn 500 505 510 aac ttt aaa ggt gaa aca ctg gcc aac gtt tat ttg gat gaa gat gag 1584 Asn Phe Lys Gly Glu Thr Leu Ala Asn Val Tyr Leu Asp Glu Asp Glu 515 520 525 gag gac gag tta ata tat gat gat agt gtt att gct gga gaa agt gaa 1632 Glu Asp Glu Leu Ile Tyr Asp Asp Ser Val Ile Ala Gly Glu Ser Glu 530 535 540 atc gcc gaa gaa act gac agt gat gat aga agc gat gaa gat tct gat 1680 Ile Ala Glu Glu Thr Asp Ser Asp Asp Arg Ser Asp Glu Asp Ser Asp 545 550 555 560 gat agt gaa tat acc gac gag tac gag tac gaa gat gac gga tta ttt 1728 Asp Ser Glu Tyr Thr Asp Glu Tyr Glu Tyr Glu Asp Asp Gly Leu Phe 565 570 575 gag cgt taa 1737 Page 297 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Arg <210> 210 <211> 578 <212> PRT <213> Saccharomyces cerevisiae <400> 210 Met Ser Ile Gln Ala Phe Val Phe Cys Gly Lys Gly Ser Asn Leu Ala 1 5 10 15 Pro Phe Thr Gln Pro Asp Phe Pro Phe Gln Thr Gln Asn Lys Asp Ser 20 25 30 Thr Ala Ala Thr Ser Gly Asp Lys Leu Asn Glu Leu Val Asn Ser Ala 35 40 45 Leu Asp Ser Thr Val Ile Asn Glu Phe Met Gln His Ser Thr Arg Leu 50 55 60 Pro Lys Ala Leu Leu Pro Ile Gly Asn Arg Pro Met Ile Glu Tyr Val 65 70 75 80 Leu Asp Trp Cys Asp Gln Ala Asp Phe Lys Glu Ile Ser Val Val Ala 85 90 95 Pro Val Asp Glu Ile Glu Leu Ile Glu Ser Gly Leu Thr Ser Phe Leu 100 105 110 Ser Leu Arg Lys Gln Gln Phe Glu Leu Ile Tyr Lys Ala Leu Ser Asn 115 120 125 Ser Asn His Ser His His Leu Gln Asp Pro Lys Lys Ile Asn Phe Ile 130 135 140 Pro Ser Lys Ala Asn Ser Thr Gly Glu Ser Leu Gln Lys Glu Leu Leu 145 150 155 160 Pro Arg Ile Asn Gly Asp Phe Val Ile Leu Pro Cys Asp Phe Val Thr 165 170 175 Asp Ile Pro Pro Gln Val Leu Val Asp Gln Phe Arg Asn Arg Asp Asp 180 185 190 Asn Asn Leu Ala Met Thr Ile Tyr Tyr Lys Asn Ser Leu Asp Ser Ser 195 200 205 Ile Asp Lys Lys Gln Gln Gln Lys Gln Lys Gln Gln Gln Phe Phe Thr 210 215 220 Val Tyr Ser Glu Asn Glu Asp Ser Glu Arg Gln Pro Ile Leu Leu Asp Page 298 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 225 230 235 240 Val Tyr Ser Gln Arg Asp Val Thr Lys Thr Lys Tyr Leu Gln Ile Arg 245 250 255 Ser His Leu Leu Trp Asn Tyr Pro Asn Leu Thr Val Ser Thr Lys Leu 260 265 270 Leu Asn Ser Phe Ile Tyr Phe Cys Ser Phe Glu Leu Cys Gln Leu Leu 275 280 285 Lys Leu Gly Pro Gln Ser Met Ser Arg Gln Ala Ser Phe Lys Asp Pro 290 295 300 Phe Thr Gly Asn Gln Gln Gln Gln Asn Pro Pro Thr Thr Asp Asp Asp 305 310 315 320 Glu Asp Arg Asn His Asp Asp Asp Asp Asp Tyr Lys Pro Ser Ala Thr 325 330 335 Ser Ile Gln Pro Thr Tyr Phe Lys Lys Lys Asn Asp Leu Ile Leu Asp 340 345 350 Pro Ile Asn Cys Asn Lys Ser Leu Ser Lys Val Phe Arg Asp Leu Ser 355 360 365 Arg Arg Ser Trp Gln His Ser Lys Pro Arg Glu Pro Ile Gly Ile Phe 370 375 380 Ile Leu Pro Asn Glu Thr Leu Phe Ile Arg Ala Asn Asn Leu Asn Ala 385 390 395 400 Tyr Met Asp Ala Asn Arg Phe Val Leu Lys Ile Lys Ser Gln Thr Met 405 410 415 Phe Thr Lys Asn Ile Gln Ile Gln Ser Ala Ala Ile Gly Ala Asp Ala 420 425 430 Ile Val Asp Pro Lys Cys Gln Ile Ser Ala His Ser Asn Val Lys Met 435 440 445 Ser Val Leu Gly Thr Gln Ala Asn Ile Gly Ser Arg Cys Arg Val Ala 450 455 460 Gly Ser Leu Leu Phe Pro Gly Val His Leu Gly Asp Glu Val Ile Leu 465 470 475 480 Glu Asn Cys Ile Ile Gly Pro Met Ala Lys Ile Gly Ser Lys Cys Lys 485 490 495 Leu Ser Asn Cys Tyr Ile Glu Gly His Tyr Val Val Glu Pro Lys Asn Page 299 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 500 505 510 Asn Phe Lys Gly Glu Thr Leu Ala Asn Val Tyr Leu Asp Glu Asp Glu 515 520 525 Glu Asp Glu Leu Ile Tyr Asp Asp Ser Val Ile Ala Gly Glu Ser Glu 530 535 540 Ile Ala Glu Glu Thr Asp Ser Asp Asp Arg Ser Asp Glu Asp Ser Asp 545 550 555 560 Asp Ser Glu Tyr Thr Asp Glu Tyr Glu Tyr Glu Asp Asp Gly Leu Phe 565 570 575 Glu Arg <210> 211 <211> 1581 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1581) <400> 211 atg tcc acc ctt ttt ctg att gga ata cac gag att gag aaa tct caa 48 Met Ser Thr Leu Phe Leu Ile Gly Ile His Glu Ile Glu Lys Ser Gln 1 5 10 15 aca att gta cag aat gaa cac tat ttt gat aga gtg att gag ctt caa 96 Thr Ile Val Gln Asn Glu His Tyr Phe Asp Arg Val Ile Glu Leu Gln 20 25 30 gat ttg gat tct ctg atg gta gca ttg tat aag gac aga gtt tcg cct 144 Asp Leu Asp Ser Leu Met Val Ala Leu Tyr Lys Asp Arg Val Ser Pro 35 40 45 ttt cca aac gtc cat aac ttt gaa acg ggc gta tct ata gtt ctt tat 192 Phe Pro Asn Val His Asn Phe Glu Thr Gly Val Ser Ile Val Leu Tyr 50 55 60 gac cct tca aaa ttt caa tta tct gtg cga caa ttg gat gtt cta ttc 240 Asp Pro Ser Lys Phe Gln Leu Ser Val Arg Gln Leu Asp Val Leu Phe 65 70 75 80 aag cga ttt ttc cca tct ttc aat att tct gcg ata gat cat aca cga 288 Lys Arg Phe Phe Pro Ser Phe Asn Ile Ser Ala Ile Asp His Thr Arg 85 90 95 gag gaa aac ctg caa cgt ctt gaa tgt gtt gag cgt gaa aat agc atc 336 Glu Glu Asn Leu Gln Arg Leu Glu Cys Val Glu Arg Glu Asn Ser Ile 100 105 110 tgt cgt aat aga ata acg aga att aac cac tgg atg tat cac cat cat 384 Cys Arg Asn Arg Ile Thr Arg Ile Asn His Trp Met Tyr His His His 115 120 125 gat gat act cca gac ggt att aac aaa aac agc tat ggt act gta aat 432 Asp Asp Thr Pro Asp Gly Ile Asn Lys Asn Ser Tyr Gly Thr Val Asn Page 300 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 130 135 140 ggg aat tct gtc ccc act caa gca tgt gaa gca aac att tac act tta 480 Gly Asn Ser Val Pro Thr Gln Ala Cys Glu Ala Asn Ile Tyr Thr Leu 145 150 155 160 tta ttg cat ttg aat gat tcc aag gca caa cat tta cga aag gca tca 528 Leu Leu His Leu Asn Asp Ser Lys Ala Gln His Leu Arg Lys Ala Ser 165 170 175 gtg cca agg cta att cgc aac atc gag ttt atg tct ttt ttg tca gat 576 Val Pro Arg Leu Ile Arg Asn Ile Glu Phe Met Ser Phe Leu Ser Asp 180 185 190 cca ata gaa aaa att tct caa gag gga tca cat tat tgg aac att cta 624 Pro Ile Glu Lys Ile Ser Gln Glu Gly Ser His Tyr Trp Asn Ile Leu 195 200 205 tca act tgg gac ttt tgt gct tta tca tta agc act caa gaa ttg att 672 Ser Thr Trp Asp Phe Cys Ala Leu Ser Leu Ser Thr Gln Glu Leu Ile 210 215 220 tgg tgc ggg ttc acg ctt atc aaa aag tta tct aag gat gca aaa gta 720 Trp Cys Gly Phe Thr Leu Ile Lys Lys Leu Ser Lys Asp Ala Lys Val 225 230 235 240 ctc att gca gat aat aag tta ctg cta cta cta ttt act tta gaa tca 768 Leu Ile Ala Asp Asn Lys Leu Leu Leu Leu Leu Phe Thr Leu Glu Ser 245 250 255 tcc tat cat caa gtt aac aaa ttt cac aat ttt agg cat gcc atc gat 816 Ser Tyr His Gln Val Asn Lys Phe His Asn Phe Arg His Ala Ile Asp 260 265 270 gtc atg caa gcc aca tgg cga ttg tgt aca tat ctt ctt aaa gat aat 864 Val Met Gln Ala Thr Trp Arg Leu Cys Thr Tyr Leu Leu Lys Asp Asn 275 280 285 cct gta caa aca tta ctg ttg tgt atg gct gcc ata ggt cat gat gtc 912 Pro Val Gln Thr Leu Leu Leu Cys Met Ala Ala Ile Gly His Asp Val 290 295 300 ggt cat cct ggg act aac aat caa cta ttg tgc aac tgt gaa tca gag 960 Gly His Pro Gly Thr Asn Asn Gln Leu Leu Cys Asn Cys Glu Ser Glu 305 310 315 320 gtt gct caa aat ttc aaa aat gtc tct atc ttg gag aat ttt cac agg 1008 Val Ala Gln Asn Phe Lys Asn Val Ser Ile Leu Glu Asn Phe His Arg 325 330 335 gaa tta ttt caa caa ttg cta tca gag cat tgg cct caa ttg cta tct 1056 Glu Leu Phe Gln Gln Leu Leu Ser Glu His Trp Pro Gln Leu Leu Ser 340 345 350 atc tcc aaa aaa aaa ttt gat ttt att tcc gag gct att ctg gcc aca 1104 Ile Ser Lys Lys Lys Phe Asp Phe Ile Ser Glu Ala Ile Leu Ala Thr 355 360 365 gat atg gca ttg cat tct cag tat gag gat aga tta atg cat gaa aac 1152 Asp Met Ala Leu His Ser Gln Tyr Glu Asp Arg Leu Met His Glu Asn 370 375 380 cca atg aaa caa atc act ttg ata tct cta att att aaa gct gca gac 1200 Pro Met Lys Gln Ile Thr Leu Ile Ser Leu Ile Ile Lys Ala Ala Asp 385 390 395 400 atc tct aat gtg acg aga acc ttg tca ata tca gca cgt tgg gca tac 1248 Ile Ser Asn Val Thr Arg Thr Leu Ser Ile Ser Ala Arg Trp Ala Tyr Page 301 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 405 410 415 ctc att act ctc gaa ttt aat gat tgc gct ctt ttg gaa aca ttt cat 1296 Leu Ile Thr Leu Glu Phe Asn Asp Cys Ala Leu Leu Glu Thr Phe His 420 425 430 aaa gct cac cgc cca gaa caa gac tgt ttt ggc gat tca tac aag aat 1344 Lys Ala His Arg Pro Glu Gln Asp Cys Phe Gly Asp Ser Tyr Lys Asn 435 440 445 gtt gat tct ccg aaa gaa gat ttg gaa tca att caa aat att ttg gtg 1392 Val Asp Ser Pro Lys Glu Asp Leu Glu Ser Ile Gln Asn Ile Leu Val 450 455 460 aac gta aca gac cct gat gat att atc aaa gac cat ccg cat att cca 1440 Asn Val Thr Asp Pro Asp Asp Ile Ile Lys Asp His Pro His Ile Pro 465 470 475 480 aac ggt caa ata ttt ttc att aat acg ttt gct gaa gta ttt ttc aac 1488 Asn Gly Gln Ile Phe Phe Ile Asn Thr Phe Ala Glu Val Phe Phe Asn 485 490 495 gca tta agt caa aaa ttc tca gga tta aaa ttt tta agc gat aat gtc 1536 Ala Leu Ser Gln Lys Phe Ser Gly Leu Lys Phe Leu Ser Asp Asn Val 500 505 510 aaa atc aat aaa gaa tac tgg atg aaa cac aag aaa cca caa tag 1581 Lys Ile Asn Lys Glu Tyr Trp Met Lys His Lys Lys Pro Gln 515 520 525 <210> 212 <211> 526 <212> PRT <213> Saccharomyces cerevisiae <400> 212 Met Ser Thr Leu Phe Leu Ile Gly Ile His Glu Ile Glu Lys Ser Gln 1 5 10 15 Thr Ile Val Gln Asn Glu His Tyr Phe Asp Arg Val Ile Glu Leu Gln 20 25 30 Asp Leu Asp Ser Leu Met Val Ala Leu Tyr Lys Asp Arg Val Ser Pro 35 40 45 Phe Pro Asn Val His Asn Phe Glu Thr Gly Val Ser Ile Val Leu Tyr 50 55 60 Asp Pro Ser Lys Phe Gln Leu Ser Val Arg Gln Leu Asp Val Leu Phe 65 70 75 80 Lys Arg Phe Phe Pro Ser Phe Asn Ile Ser Ala Ile Asp His Thr Arg 85 90 95 Glu Glu Asn Leu Gln Arg Leu Glu Cys Val Glu Arg Glu Asn Ser Ile 100 105 110 Cys Arg Asn Arg Ile Thr Arg Ile Asn His Trp Met Tyr His His His 115 120 125 Page 302 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Asp Thr Pro Asp Gly Ile Asn Lys Asn Ser Tyr Gly Thr Val Asn 130 135 140 Gly Asn Ser Val Pro Thr Gln Ala Cys Glu Ala Asn Ile Tyr Thr Leu 145 150 155 160 Leu Leu His Leu Asn Asp Ser Lys Ala Gln His Leu Arg Lys Ala Ser 165 170 175 Val Pro Arg Leu Ile Arg Asn Ile Glu Phe Met Ser Phe Leu Ser Asp 180 185 190 Pro Ile Glu Lys Ile Ser Gln Glu Gly Ser His Tyr Trp Asn Ile Leu 195 200 205 Ser Thr Trp Asp Phe Cys Ala Leu Ser Leu Ser Thr Gln Glu Leu Ile 210 215 220 Trp Cys Gly Phe Thr Leu Ile Lys Lys Leu Ser Lys Asp Ala Lys Val 225 230 235 240 Leu Ile Ala Asp Asn Lys Leu Leu Leu Leu Leu Phe Thr Leu Glu Ser 245 250 255 Ser Tyr His Gln Val Asn Lys Phe His Asn Phe Arg His Ala Ile Asp 260 265 270 Val Met Gln Ala Thr Trp Arg Leu Cys Thr Tyr Leu Leu Lys Asp Asn 275 280 285 Pro Val Gln Thr Leu Leu Leu Cys Met Ala Ala Ile Gly His Asp Val 290 295 300 Gly His Pro Gly Thr Asn Asn Gln Leu Leu Cys Asn Cys Glu Ser Glu 305 310 315 320 Val Ala Gln Asn Phe Lys Asn Val Ser Ile Leu Glu Asn Phe His Arg 325 330 335 Glu Leu Phe Gln Gln Leu Leu Ser Glu His Trp Pro Gln Leu Leu Ser 340 345 350 Ile Ser Lys Lys Lys Phe Asp Phe Ile Ser Glu Ala Ile Leu Ala Thr 355 360 365 Asp Met Ala Leu His Ser Gln Tyr Glu Asp Arg Leu Met His Glu Asn 370 375 380 Pro Met Lys Gln Ile Thr Leu Ile Ser Leu Ile Ile Lys Ala Ala Asp 385 390 395 400 Page 303 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Ser Asn Val Thr Arg Thr Leu Ser Ile Ser Ala Arg Trp Ala Tyr 405 410 415 Leu Ile Thr Leu Glu Phe Asn Asp Cys Ala Leu Leu Glu Thr Phe His 420 425 430 Lys Ala His Arg Pro Glu Gln Asp Cys Phe Gly Asp Ser Tyr Lys Asn 435 440 445 Val Asp Ser Pro Lys Glu Asp Leu Glu Ser Ile Gln Asn Ile Leu Val 450 455 460 Asn Val Thr Asp Pro Asp Asp Ile Ile Lys Asp His Pro His Ile Pro 465 470 475 480 Asn Gly Gln Ile Phe Phe Ile Asn Thr Phe Ala Glu Val Phe Phe Asn 485 490 495 Ala Leu Ser Gln Lys Phe Ser Gly Leu Lys Phe Leu Ser Asp Asn Val 500 505 510 Lys Ile Asn Lys Glu Tyr Trp Met Lys His Lys Lys Pro Gln 515 520 525 <210> 213 <211> 2367 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2367) <400> 213 atg gca ggt cat tca cac agg tca tca tta aaa aac gga cac aaa tct 48 Met Ala Gly His Ser His Arg Ser Ser Leu Lys Asn Gly His Lys Ser 1 5 10 15 tac aaa tcc aaa cat gct tct aaa ggt gct ttg aaa aga tta tac aag 96 Tyr Lys Ser Lys His Ala Ser Lys Gly Ala Leu Lys Arg Leu Tyr Lys 20 25 30 ggg aaa gtg gaa aaa gaa ccc gtg ggc act ggc aaa cca gac aaa caa 144 Gly Lys Val Glu Lys Glu Pro Val Gly Thr Gly Lys Pro Asp Lys Gln 35 40 45 gtt tca aaa ttg caa cgt aaa aac aag gca aaa caa tta agg gcc caa 192 Val Ser Lys Leu Gln Arg Lys Asn Lys Ala Lys Gln Leu Arg Ala Gln 50 55 60 agg atc ttg gat tcc att gaa aac agg aaa tta ttc gaa gga aaa aat 240 Arg Ile Leu Asp Ser Ile Glu Asn Arg Lys Leu Phe Glu Gly Lys Asn 65 70 75 80 ggc gct gcc aaa atc att act att gtt ccg tta gtg aat gat tta gac 288 Gly Ala Ala Lys Ile Ile Thr Ile Val Pro Leu Val Asn Asp Leu Asp 85 90 95 Page 304 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cca ttg gac att ctt tac aag cta tta aag tgt gca gat gat gaa gga 336 Pro Leu Asp Ile Leu Tyr Lys Leu Leu Lys Cys Ala Asp Asp Glu Gly 100 105 110 atc atg gtg cag gaa gta gac tca aaa cgt ata ttt aat gtt cat ata 384 Ile Met Val Gln Glu Val Asp Ser Lys Arg Ile Phe Asn Val His Ile 115 120 125 aag aag ttt aaa agc aat ctt aaa atc ata att cca gac atg acc aat 432 Lys Lys Phe Lys Ser Asn Leu Lys Ile Ile Ile Pro Asp Met Thr Asn 130 135 140 ttt ttg aac att tta gat tgc gct aaa gta gca gac ttt gtt gtg ttt 480 Phe Leu Asn Ile Leu Asp Cys Ala Lys Val Ala Asp Phe Val Val Phe 145 150 155 160 ggg ctc agt ggt gtc caa gaa gtc gat gaa gaa ttt ggt gag cag atc 528 Gly Leu Ser Gly Val Gln Glu Val Asp Glu Glu Phe Gly Glu Gln Ile 165 170 175 atc cgt gcg tta gaa cta caa ggt att gct tca tat atc ggt gtc ata 576 Ile Arg Ala Leu Glu Leu Gln Gly Ile Ala Ser Tyr Ile Gly Val Ile 180 185 190 agc aac ctc tca gca gtc cat gaa aag gag aaa ttc caa ttg gat gtc 624 Ser Asn Leu Ser Ala Val His Glu Lys Glu Lys Phe Gln Leu Asp Val 195 200 205 aag caa tcc tta gaa agt tat ttc aag cac ttt ttc cca agt gaa gaa 672 Lys Gln Ser Leu Glu Ser Tyr Phe Lys His Phe Phe Pro Ser Glu Glu 210 215 220 cgt gtt tat aat ttg gaa aaa aac tca gac gct tta aac gtc ttg aga 720 Arg Val Tyr Asn Leu Glu Lys Asn Ser Asp Ala Leu Asn Val Leu Arg 225 230 235 240 aca ttg tgc cag agg cta cca aga tca atc aat tgg aga gac aat aga 768 Thr Leu Cys Gln Arg Leu Pro Arg Ser Ile Asn Trp Arg Asp Asn Arg 245 250 255 ggt tac gta gtc gct gac ttt gtt gat ttc gtt gaa acc tct ccc gat 816 Gly Tyr Val Val Ala Asp Phe Val Asp Phe Val Glu Thr Ser Pro Asp 260 265 270 tct ggt gac ctg gta att gag ggg acc gtc cgt ggt att ggc ttc aac 864 Ser Gly Asp Leu Val Ile Glu Gly Thr Val Arg Gly Ile Gly Phe Asn 275 280 285 gcc aat aga ctg gtc cat att cct gat ttt ggt gac ttc caa ctg aat 912 Ala Asn Arg Leu Val His Ile Pro Asp Phe Gly Asp Phe Gln Leu Asn 290 295 300 aag ata gaa aaa atc agt gaa tct tcg cag aaa agg aaa ata ata aag 960 Lys Ile Glu Lys Ile Ser Glu Ser Ser Gln Lys Arg Lys Ile Ile Lys 305 310 315 320 gaa aaa gct aca gat agt ctg agc tta gag ctg gat tta caa aca gtt 1008 Glu Lys Ala Thr Asp Ser Leu Ser Leu Glu Leu Asp Leu Gln Thr Val 325 330 335 ttc gaa agt aat atg aat aga gat act ttg gac gaa tat gcc cca gaa 1056 Phe Glu Ser Asn Met Asn Arg Asp Thr Leu Asp Glu Tyr Ala Pro Glu 340 345 350 ggc acg gaa gat tgg tca gat tat gac gag gat ttt gag tac gac ggt 1104 Gly Thr Glu Asp Trp Ser Asp Tyr Asp Glu Asp Phe Glu Tyr Asp Gly 355 360 365 Page 305 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttg aca acc gcg aga tac gac gac cat ggc ttc ttg cca ggg agg gaa 1152 Leu Thr Thr Ala Arg Tyr Asp Asp His Gly Phe Leu Pro Gly Arg Glu 370 375 380 caa aca tca aaa aag gcg gca gtt cct aag gga act tct gac tat caa 1200 Gln Thr Ser Lys Lys Ala Ala Val Pro Lys Gly Thr Ser Asp Tyr Gln 385 390 395 400 gcg aag tgg tac ttg gat gac gtc att gac gca aat gag gaa gaa gag 1248 Ala Lys Trp Tyr Leu Asp Asp Val Ile Asp Ala Asn Glu Glu Glu Glu 405 410 415 gca gaa cag acc aat gga aag gat gag aca atg atg gaa att gat gat 1296 Ala Glu Gln Thr Asn Gly Lys Asp Glu Thr Met Met Glu Ile Asp Asp 420 425 430 gaa atg atg gtg gag caa gac aat gaa gag gta gca ggc gac gaa gaa 1344 Glu Met Met Val Glu Gln Asp Asn Glu Glu Val Ala Gly Asp Glu Glu 435 440 445 tat gac ata gag gat aat gaa gga ttt gaa gag ctt tca ccc gaa gaa 1392 Tyr Asp Ile Glu Asp Asn Glu Gly Phe Glu Glu Leu Ser Pro Glu Glu 450 455 460 gaa gaa cgt caa ctg agg gaa ttt aga gat atg gaa aag gag gac aga 1440 Glu Glu Arg Gln Leu Arg Glu Phe Arg Asp Met Glu Lys Glu Asp Arg 465 470 475 480 gag ttc ccc gat gag atc gaa cta gag ccc agt gaa tct gcc atc gaa 1488 Glu Phe Pro Asp Glu Ile Glu Leu Glu Pro Ser Glu Ser Ala Ile Glu 485 490 495 cgt ttg aaa agg tat aga ggt ttg aaa aac tta tac aac tgt gat tgg 1536 Arg Leu Lys Arg Tyr Arg Gly Leu Lys Asn Leu Tyr Asn Cys Asp Trp 500 505 510 caa gtt gat gaa aag gac cca tca tca cca gcg gaa tgg aaa cgt cta 1584 Gln Val Asp Glu Lys Asp Pro Ser Ser Pro Ala Glu Trp Lys Arg Leu 515 520 525 tta agg att ggc aat tac aaa aac act aaa aac aga atc ata aag gaa 1632 Leu Arg Ile Gly Asn Tyr Lys Asn Thr Lys Asn Arg Ile Ile Lys Glu 530 535 540 acc aag aat gaa gca cag gcc att gca ggt gat cgt att agg atg ttc 1680 Thr Lys Asn Glu Ala Gln Ala Ile Ala Gly Asp Arg Ile Arg Met Phe 545 550 555 560 atc agg ttt cct aag ttt ctg ctt gaa aag att caa gat cct aaa caa 1728 Ile Arg Phe Pro Lys Phe Leu Leu Glu Lys Ile Gln Asp Pro Lys Gln 565 570 575 cta tta ttt gct gtc tac gga tta cta ctt cat gaa cac aaa aat gcg 1776 Leu Leu Phe Ala Val Tyr Gly Leu Leu Leu His Glu His Lys Asn Ala 580 585 590 gta gtc aac ttc tct cta caa aga tgg gaa caa tat gac aaa cct gtg 1824 Val Val Asn Phe Ser Leu Gln Arg Trp Glu Gln Tyr Asp Lys Pro Val 595 600 605 cct tct cag gag cct atc gta gta caa tac ggt gtt aga aga tac act 1872 Pro Ser Gln Glu Pro Ile Val Val Gln Tyr Gly Val Arg Arg Tyr Thr 610 615 620 att caa cct cta ttt tct caa ggc tct aac agt cct aat aat gtt cac 1920 Ile Gln Pro Leu Phe Ser Gln Gly Ser Asn Ser Pro Asn Asn Val His 625 630 635 640 Page 306 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag tat gaa agg ttt ctg cat cca gat aca gta tca gtt gcc aca tgt 1968 Lys Tyr Glu Arg Phe Leu His Pro Asp Thr Val Ser Val Ala Thr Cys 645 650 655 att gct ccc gta gat ttc acc cag tca cct gca att ttt ttc aag cca 2016 Ile Ala Pro Val Asp Phe Thr Gln Ser Pro Ala Ile Phe Phe Lys Pro 660 665 670 tca cca aca gat gcc aaa aat att gaa ttg att ggt cac ggt aca ttc 2064 Ser Pro Thr Asp Ala Lys Asn Ile Glu Leu Ile Gly His Gly Thr Phe 675 680 685 ctg aat gca gac cat tca aga ata tta gca aag aga gcc att ttg acc 2112 Leu Asn Ala Asp His Ser Arg Ile Leu Ala Lys Arg Ala Ile Leu Thr 690 695 700 ggt cat cca ttc aga ttc cac aaa act gtg gtt act gta cgt tac atg 2160 Gly His Pro Phe Arg Phe His Lys Thr Val Val Thr Val Arg Tyr Met 705 710 715 720 ttt ttc aga cca gaa gat gtg gaa tgg ttc aag tct atc cca ctg ttc 2208 Phe Phe Arg Pro Glu Asp Val Glu Trp Phe Lys Ser Ile Pro Leu Phe 725 730 735 acc aaa tca ggt agg tca ggt ttc att aaa gaa agt ttg ggt acg cat 2256 Thr Lys Ser Gly Arg Ser Gly Phe Ile Lys Glu Ser Leu Gly Thr His 740 745 750 ggt tat ttc aag gct aca ttt gat ggt aaa tta tct gcg cag gat gtt 2304 Gly Tyr Phe Lys Ala Thr Phe Asp Gly Lys Leu Ser Ala Gln Asp Val 755 760 765 gtt gct atg tcc ttg tac aaa cgt atg tgg ccc atg cct tcg tta cct 2352 Val Ala Met Ser Leu Tyr Lys Arg Met Trp Pro Met Pro Ser Leu Pro 770 775 780 tgg aat ggt atg taa 2367 Trp Asn Gly Met 785 <210> 214 <211> 788 <212> PRT <213> Saccharomyces cerevisiae <400> 214 Met Ala Gly His Ser His Arg Ser Ser Leu Lys Asn Gly His Lys Ser 1 5 10 15 Tyr Lys Ser Lys His Ala Ser Lys Gly Ala Leu Lys Arg Leu Tyr Lys 20 25 30 Gly Lys Val Glu Lys Glu Pro Val Gly Thr Gly Lys Pro Asp Lys Gln 35 40 45 Val Ser Lys Leu Gln Arg Lys Asn Lys Ala Lys Gln Leu Arg Ala Gln 50 55 60 Arg Ile Leu Asp Ser Ile Glu Asn Arg Lys Leu Phe Glu Gly Lys Asn 65 70 75 80 Page 307 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Ala Ala Lys Ile Ile Thr Ile Val Pro Leu Val Asn Asp Leu Asp 85 90 95 Pro Leu Asp Ile Leu Tyr Lys Leu Leu Lys Cys Ala Asp Asp Glu Gly 100 105 110 Ile Met Val Gln Glu Val Asp Ser Lys Arg Ile Phe Asn Val His Ile 115 120 125 Lys Lys Phe Lys Ser Asn Leu Lys Ile Ile Ile Pro Asp Met Thr Asn 130 135 140 Phe Leu Asn Ile Leu Asp Cys Ala Lys Val Ala Asp Phe Val Val Phe 145 150 155 160 Gly Leu Ser Gly Val Gln Glu Val Asp Glu Glu Phe Gly Glu Gln Ile 165 170 175 Ile Arg Ala Leu Glu Leu Gln Gly Ile Ala Ser Tyr Ile Gly Val Ile 180 185 190 Ser Asn Leu Ser Ala Val His Glu Lys Glu Lys Phe Gln Leu Asp Val 195 200 205 Lys Gln Ser Leu Glu Ser Tyr Phe Lys His Phe Phe Pro Ser Glu Glu 210 215 220 Arg Val Tyr Asn Leu Glu Lys Asn Ser Asp Ala Leu Asn Val Leu Arg 225 230 235 240 Thr Leu Cys Gln Arg Leu Pro Arg Ser Ile Asn Trp Arg Asp Asn Arg 245 250 255 Gly Tyr Val Val Ala Asp Phe Val Asp Phe Val Glu Thr Ser Pro Asp 260 265 270 Ser Gly Asp Leu Val Ile Glu Gly Thr Val Arg Gly Ile Gly Phe Asn 275 280 285 Ala Asn Arg Leu Val His Ile Pro Asp Phe Gly Asp Phe Gln Leu Asn 290 295 300 Lys Ile Glu Lys Ile Ser Glu Ser Ser Gln Lys Arg Lys Ile Ile Lys 305 310 315 320 Glu Lys Ala Thr Asp Ser Leu Ser Leu Glu Leu Asp Leu Gln Thr Val 325 330 335 Phe Glu Ser Asn Met Asn Arg Asp Thr Leu Asp Glu Tyr Ala Pro Glu 340 345 350 Page 308 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Thr Glu Asp Trp Ser Asp Tyr Asp Glu Asp Phe Glu Tyr Asp Gly 355 360 365 Leu Thr Thr Ala Arg Tyr Asp Asp His Gly Phe Leu Pro Gly Arg Glu 370 375 380 Gln Thr Ser Lys Lys Ala Ala Val Pro Lys Gly Thr Ser Asp Tyr Gln 385 390 395 400 Ala Lys Trp Tyr Leu Asp Asp Val Ile Asp Ala Asn Glu Glu Glu Glu 405 410 415 Ala Glu Gln Thr Asn Gly Lys Asp Glu Thr Met Met Glu Ile Asp Asp 420 425 430 Glu Met Met Val Glu Gln Asp Asn Glu Glu Val Ala Gly Asp Glu Glu 435 440 445 Tyr Asp Ile Glu Asp Asn Glu Gly Phe Glu Glu Leu Ser Pro Glu Glu 450 455 460 Glu Glu Arg Gln Leu Arg Glu Phe Arg Asp Met Glu Lys Glu Asp Arg 465 470 475 480 Glu Phe Pro Asp Glu Ile Glu Leu Glu Pro Ser Glu Ser Ala Ile Glu 485 490 495 Arg Leu Lys Arg Tyr Arg Gly Leu Lys Asn Leu Tyr Asn Cys Asp Trp 500 505 510 Gln Val Asp Glu Lys Asp Pro Ser Ser Pro Ala Glu Trp Lys Arg Leu 515 520 525 Leu Arg Ile Gly Asn Tyr Lys Asn Thr Lys Asn Arg Ile Ile Lys Glu 530 535 540 Thr Lys Asn Glu Ala Gln Ala Ile Ala Gly Asp Arg Ile Arg Met Phe 545 550 555 560 Ile Arg Phe Pro Lys Phe Leu Leu Glu Lys Ile Gln Asp Pro Lys Gln 565 570 575 Leu Leu Phe Ala Val Tyr Gly Leu Leu Leu His Glu His Lys Asn Ala 580 585 590 Val Val Asn Phe Ser Leu Gln Arg Trp Glu Gln Tyr Asp Lys Pro Val 595 600 605 Pro Ser Gln Glu Pro Ile Val Val Gln Tyr Gly Val Arg Arg Tyr Thr 610 615 620 Page 309 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Gln Pro Leu Phe Ser Gln Gly Ser Asn Ser Pro Asn Asn Val His 625 630 635 640 Lys Tyr Glu Arg Phe Leu His Pro Asp Thr Val Ser Val Ala Thr Cys 645 650 655 Ile Ala Pro Val Asp Phe Thr Gln Ser Pro Ala Ile Phe Phe Lys Pro 660 665 670 Ser Pro Thr Asp Ala Lys Asn Ile Glu Leu Ile Gly His Gly Thr Phe 675 680 685 Leu Asn Ala Asp His Ser Arg Ile Leu Ala Lys Arg Ala Ile Leu Thr 690 695 700 Gly His Pro Phe Arg Phe His Lys Thr Val Val Thr Val Arg Tyr Met 705 710 715 720 Phe Phe Arg Pro Glu Asp Val Glu Trp Phe Lys Ser Ile Pro Leu Phe 725 730 735 Thr Lys Ser Gly Arg Ser Gly Phe Ile Lys Glu Ser Leu Gly Thr His 740 745 750 Gly Tyr Phe Lys Ala Thr Phe Asp Gly Lys Leu Ser Ala Gln Asp Val 755 760 765 Val Ala Met Ser Leu Tyr Lys Arg Met Trp Pro Met Pro Ser Leu Pro 770 775 780 Trp Asn Gly Met 785 <210> 215 <211> 1296 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1296) <400> 215 atg gta gta caa aat agc cca gtt tcg tct gtt cac aca gcc aat ttc 48 Met Val Val Gln Asn Ser Pro Val Ser Ser Val His Thr Ala Asn Phe 1 5 10 15 tct gaa cgg ggg agc aat acc aga aca atg acg tat aaa aat aag ctt 96 Ser Glu Arg Gly Ser Asn Thr Arg Thr Met Thr Tyr Lys Asn Lys Leu 20 25 30 act gtt tgc ttc gat gac atc cta aaa gtt gga gca gaa atg atg atg 144 Thr Val Cys Phe Asp Asp Ile Leu Lys Val Gly Ala Glu Met Met Met 35 40 45 Page 310 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt caa caa cag tta aaa aat gta caa cta gat tct tat ctc gtc aat ggt 192 Gln Gln Gln Leu Lys Asn Val Gln Leu Asp Ser Tyr Leu Val Asn Gly 50 55 60 ttc agt caa tct cag caa aaa tta ttg aaa gag aag gtt aaa tta ttt 240 Phe Ser Gln Ser Gln Gln Lys Leu Leu Lys Glu Lys Val Lys Leu Phe 65 70 75 80 cat gga att tta gat gat tta gag act tct cta agc cag agt tct tca 288 His Gly Ile Leu Asp Asp Leu Glu Thr Ser Leu Ser Gln Ser Ser Ser 85 90 95 tat tta gaa act ctt act gca ctc gga aaa gaa aag gag aaa gaa aga 336 Tyr Leu Glu Thr Leu Thr Ala Leu Gly Lys Glu Lys Glu Lys Glu Arg 100 105 110 gag gaa gct gaa aaa aag agg gct gaa caa gaa aat atg agg aag gtt 384 Glu Glu Ala Glu Lys Lys Arg Ala Glu Gln Glu Asn Met Arg Lys Val 115 120 125 aga gaa caa gaa gaa tta aaa aag cga caa gaa ctc gaa gaa gcc tcc 432 Arg Glu Gln Glu Glu Leu Lys Lys Arg Gln Glu Leu Glu Glu Ala Ser 130 135 140 caa cag cag caa ctc cag caa aat tca aag gaa aaa aat ggc ctt ggt 480 Gln Gln Gln Gln Leu Gln Gln Asn Ser Lys Glu Lys Asn Gly Leu Gly 145 150 155 160 ttg aac ttc tcc aca aca gca cct gcg aac aca acg gat gcc aac ggt 528 Leu Asn Phe Ser Thr Thr Ala Pro Ala Asn Thr Thr Asp Ala Asn Gly 165 170 175 tcc aaa gag aat tat caa gaa ctt gga tct ctt caa tca tcc agt caa 576 Ser Lys Glu Asn Tyr Gln Glu Leu Gly Ser Leu Gln Ser Ser Ser Gln 180 185 190 aca caa ctt gag aac gca aat gct gct aat aac ggt gcc gca ttt tct 624 Thr Gln Leu Glu Asn Ala Asn Ala Ala Asn Asn Gly Ala Ala Phe Ser 195 200 205 ccc tta acc act act cga atc caa agc cag cag gcc caa ccc tcg gat 672 Pro Leu Thr Thr Thr Arg Ile Gln Ser Gln Gln Ala Gln Pro Ser Asp 210 215 220 gta atg ttc aac gat tta aac tct atg gat att tcg atg ttt tca ggc 720 Val Met Phe Asn Asp Leu Asn Ser Met Asp Ile Ser Met Phe Ser Gly 225 230 235 240 ctt gac agt act ggt ttt gac tcc aca gcc ttc aat gcc acg gtg gac 768 Leu Asp Ser Thr Gly Phe Asp Ser Thr Ala Phe Asn Ala Thr Val Asp 245 250 255 gaa acc aaa ggc ttt gac gat aat gac tca ggt aac aac tac aat gac 816 Glu Thr Lys Gly Phe Asp Asp Asn Asp Ser Gly Asn Asn Tyr Asn Asp 260 265 270 ata aat att tct tct att gaa aac aac ata aat aat aat atc aat agc 864 Ile Asn Ile Ser Ser Ile Glu Asn Asn Ile Asn Asn Asn Ile Asn Ser 275 280 285 acc aag aac ggc aag gat aac aac aac gaa agc aac aaa aat aac aac 912 Thr Lys Asn Gly Lys Asp Asn Asn Asn Glu Ser Asn Lys Asn Asn Asn 290 295 300 ggc gat gaa aag aat aag aac aac aac gag gac aac gag aac aac aac 960 Gly Asp Glu Lys Asn Lys Asn Asn Asn Glu Asp Asn Glu Asn Asn Asn 305 310 315 320 Page 311 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aac agc agt gag aag aac aac aat aat aat aat aat aac aat aac aac 1008 Asn Ser Ser Glu Lys Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 325 330 335 aat gac gat aac ggc aac aac aac aac aac aac agt ggg aac gac aat 1056 Asn Asp Asp Asn Gly Asn Asn Asn Asn Asn Asn Ser Gly Asn Asp Asn 340 345 350 aac aat acc acc aac aac gac agc aat aac aag aac aat tct atc act 1104 Asn Asn Thr Thr Asn Asn Asp Ser Asn Asn Lys Asn Asn Ser Ile Thr 355 360 365 acc gga aat gat aat gaa aat ata gtt aat aat gat tta cca acg acc 1152 Thr Gly Asn Asp Asn Glu Asn Ile Val Asn Asn Asp Leu Pro Thr Thr 370 375 380 gtt gtt tcc aat cct gga gat aac cct cct cca gcc gac aac ggt gaa 1200 Val Val Ser Asn Pro Gly Asp Asn Pro Pro Pro Ala Asp Asn Gly Glu 385 390 395 400 gaa tac ttg aca tta aat gat ttc aac gac ctt aat att gac tgg tcg 1248 Glu Tyr Leu Thr Leu Asn Asp Phe Asn Asp Leu Asn Ile Asp Trp Ser 405 410 415 acc act gga gat aat ggc gaa tta gac ctc agc ggc ttc aat ata tag 1296 Thr Thr Gly Asp Asn Gly Glu Leu Asp Leu Ser Gly Phe Asn Ile 420 425 430 <210> 216 <211> 431 <212> PRT <213> Saccharomyces cerevisiae <400> 216 Met Val Val Gln Asn Ser Pro Val Ser Ser Val His Thr Ala Asn Phe 1 5 10 15 Ser Glu Arg Gly Ser Asn Thr Arg Thr Met Thr Tyr Lys Asn Lys Leu 20 25 30 Thr Val Cys Phe Asp Asp Ile Leu Lys Val Gly Ala Glu Met Met Met 35 40 45 Gln Gln Gln Leu Lys Asn Val Gln Leu Asp Ser Tyr Leu Val Asn Gly 50 55 60 Phe Ser Gln Ser Gln Gln Lys Leu Leu Lys Glu Lys Val Lys Leu Phe 65 70 75 80 His Gly Ile Leu Asp Asp Leu Glu Thr Ser Leu Ser Gln Ser Ser Ser 85 90 95 Tyr Leu Glu Thr Leu Thr Ala Leu Gly Lys Glu Lys Glu Lys Glu Arg 100 105 110 Glu Glu Ala Glu Lys Lys Arg Ala Glu Gln Glu Asn Met Arg Lys Val 115 120 125 Page 312 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Glu Gln Glu Glu Leu Lys Lys Arg Gln Glu Leu Glu Glu Ala Ser 130 135 140 Gln Gln Gln Gln Leu Gln Gln Asn Ser Lys Glu Lys Asn Gly Leu Gly 145 150 155 160 Leu Asn Phe Ser Thr Thr Ala Pro Ala Asn Thr Thr Asp Ala Asn Gly 165 170 175 Ser Lys Glu Asn Tyr Gln Glu Leu Gly Ser Leu Gln Ser Ser Ser Gln 180 185 190 Thr Gln Leu Glu Asn Ala Asn Ala Ala Asn Asn Gly Ala Ala Phe Ser 195 200 205 Pro Leu Thr Thr Thr Arg Ile Gln Ser Gln Gln Ala Gln Pro Ser Asp 210 215 220 Val Met Phe Asn Asp Leu Asn Ser Met Asp Ile Ser Met Phe Ser Gly 225 230 235 240 Leu Asp Ser Thr Gly Phe Asp Ser Thr Ala Phe Asn Ala Thr Val Asp 245 250 255 Glu Thr Lys Gly Phe Asp Asp Asn Asp Ser Gly Asn Asn Tyr Asn Asp 260 265 270 Ile Asn Ile Ser Ser Ile Glu Asn Asn Ile Asn Asn Asn Ile Asn Ser 275 280 285 Thr Lys Asn Gly Lys Asp Asn Asn Asn Glu Ser Asn Lys Asn Asn Asn 290 295 300 Gly Asp Glu Lys Asn Lys Asn Asn Asn Glu Asp Asn Glu Asn Asn Asn 305 310 315 320 Asn Ser Ser Glu Lys Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn 325 330 335 Asn Asp Asp Asn Gly Asn Asn Asn Asn Asn Asn Ser Gly Asn Asp Asn 340 345 350 Asn Asn Thr Thr Asn Asn Asp Ser Asn Asn Lys Asn Asn Ser Ile Thr 355 360 365 Thr Gly Asn Asp Asn Glu Asn Ile Val Asn Asn Asp Leu Pro Thr Thr 370 375 380 Val Val Ser Asn Pro Gly Asp Asn Pro Pro Pro Ala Asp Asn Gly Glu 385 390 395 400 Page 313 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Tyr Leu Thr Leu Asn Asp Phe Asn Asp Leu Asn Ile Asp Trp Ser 405 410 415 Thr Thr Gly Asp Asn Gly Glu Leu Asp Leu Ser Gly Phe Asn Ile 420 425 430 <210> 217 <211> 1941 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1941) <400> 217 atg aaa gaa agc aaa aaa atg gct aaa gat aat tta act aat ttg ctc 48 Met Lys Glu Ser Lys Lys Met Ala Lys Asp Asn Leu Thr Asn Leu Leu 1 5 10 15 tct caa ttg aac att caa ttg tct caa gac gag cat tcg cag gtc gaa 96 Ser Gln Leu Asn Ile Gln Leu Ser Gln Asp Glu His Ser Gln Val Glu 20 25 30 cag act tgc gtg aaa cta ttg gat tct gga tgt gag aat cca gcg gat 144 Gln Thr Cys Val Lys Leu Leu Asp Ser Gly Cys Glu Asn Pro Ala Asp 35 40 45 gta ttt aga cgt tgc tta gta gct gtt atc caa cag gac aag tat caa 192 Val Phe Arg Arg Cys Leu Val Ala Val Ile Gln Gln Asp Lys Tyr Gln 50 55 60 aag gct tta cat tat tta aaa aaa ttc aaa cat ata gat gac aag tac 240 Lys Ala Leu His Tyr Leu Lys Lys Phe Lys His Ile Asp Asp Lys Tyr 65 70 75 80 ggt cgc aaa ttt gcg cta gaa aaa ttg tac att ttc tat aaa ttg aat 288 Gly Arg Lys Phe Ala Leu Glu Lys Leu Tyr Ile Phe Tyr Lys Leu Asn 85 90 95 atg cca gat gaa ttc aac aca ttg tac aca gca att atc aca gat gat 336 Met Pro Asp Glu Phe Asn Thr Leu Tyr Thr Ala Ile Ile Thr Asp Asp 100 105 110 ctc gat acg gta cta aaa aag gat atc gag tca ctt aga ggt atc cta 384 Leu Asp Thr Val Leu Lys Lys Asp Ile Glu Ser Leu Arg Gly Ile Leu 115 120 125 cat gtg aga gct caa tat tgt tat aaa aat ggg ctg tac caa gaa gct 432 His Val Arg Ala Gln Tyr Cys Tyr Lys Asn Gly Leu Tyr Gln Glu Ala 130 135 140 ttt aaa ata tat caa cat tta gca agt cac aat gag aag gat cag gat 480 Phe Lys Ile Tyr Gln His Leu Ala Ser His Asn Glu Lys Asp Gln Asp 145 150 155 160 agt caa att gaa ctc tct tgt aac gaa agg gtt ccg cta tcc gtt gcg 528 Ser Gln Ile Glu Leu Ser Cys Asn Glu Arg Val Pro Leu Ser Val Ala 165 170 175 aca gag tta atg aac aga tca ccc tta gtt act cct atg gat gaa tct 576 Thr Glu Leu Met Asn Arg Ser Pro Leu Val Thr Pro Met Asp Glu Ser 180 185 190 tcc tac gat tta tta ttc aat gaa tca ttc atc atg gca tcc gta ggt 624 Page 314 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Tyr Asp Leu Leu Phe Asn Glu Ser Phe Ile Met Ala Ser Val Gly 195 200 205 aaa tat gac aag gct atc gaa cta tta gaa aaa gcg ctt caa gga gcc 672 Lys Tyr Asp Lys Ala Ile Glu Leu Leu Glu Lys Ala Leu Gln Gly Ala 210 215 220 acg aat gaa ggc tat caa aac gat att aat act att aaa ttg caa tta 720 Thr Asn Glu Gly Tyr Gln Asn Asp Ile Asn Thr Ile Lys Leu Gln Leu 225 230 235 240 tca ttt gtt ttg caa atg gtg ggg aaa act gca caa agt aaa gaa atc 768 Ser Phe Val Leu Gln Met Val Gly Lys Thr Ala Gln Ser Lys Glu Ile 245 250 255 tta aag ggc tta ttg cag gaa ctg aaa gcc gat tct cca ttc tct tta 816 Leu Lys Gly Leu Leu Gln Glu Leu Lys Ala Asp Ser Pro Phe Ser Leu 260 265 270 att tgt caa aat aac cta aat gcg ttt gtt gat ttc tct aaa tac aat 864 Ile Cys Gln Asn Asn Leu Asn Ala Phe Val Asp Phe Ser Lys Tyr Asn 275 280 285 aca aac ttc aat tta ctg tta agg gaa tta aac gta gaa aaa cta aac 912 Thr Asn Phe Asn Leu Leu Leu Arg Glu Leu Asn Val Glu Lys Leu Asn 290 295 300 act ttt aat tta caa acc ttc acc cat gaa caa tgg tca aac att caa 960 Thr Phe Asn Leu Gln Thr Phe Thr His Glu Gln Trp Ser Asn Ile Gln 305 310 315 320 cgc aat gta ctt ttc ctg cgt ttg ttc aac aat gtc aaa att cac tct 1008 Arg Asn Val Leu Phe Leu Arg Leu Phe Asn Asn Val Lys Ile His Ser 325 330 335 caa gag tcc ctt tta tca aga acg ttc gat aaa tac tct aag tta gtt 1056 Gln Glu Ser Leu Leu Ser Arg Thr Phe Asp Lys Tyr Ser Lys Leu Val 340 345 350 gac aat gtt act ttg gaa agc tac aag acg cag gcc aag aaa ctt tac 1104 Asp Asn Val Thr Leu Glu Ser Tyr Lys Thr Gln Ala Lys Lys Leu Tyr 355 360 365 cac cac act aca aaa acc att tta agt gga aca gat gga agt acg att 1152 His His Thr Thr Lys Thr Ile Leu Ser Gly Thr Asp Gly Ser Thr Ile 370 375 380 gga ata tta cta ctg act atc caa ttg cta ata ata gag aag gaa tgg 1200 Gly Ile Leu Leu Leu Thr Ile Gln Leu Leu Ile Ile Glu Lys Glu Trp 385 390 395 400 gaa aat gct atc aga ata gga gaa tta ttt tta aat gaa agc tgg aaa 1248 Glu Asn Ala Ile Arg Ile Gly Glu Leu Phe Leu Asn Glu Ser Trp Lys 405 410 415 tcg tcc ttt gaa aaa ttc aac gat tca caa gcc atc gtg tgt tac att 1296 Ser Ser Phe Glu Lys Phe Asn Asp Ser Gln Ala Ile Val Cys Tyr Ile 420 425 430 tta ttt gaa tta tac aag att aag gga aga aac aac tcc aaa agt gtt 1344 Leu Phe Glu Leu Tyr Lys Ile Lys Gly Arg Asn Asn Ser Lys Ser Val 435 440 445 ctg ctt aaa aaa tta ggc tcc gtg aga gtc caa ttg agc gga aaa atc 1392 Leu Leu Lys Lys Leu Gly Ser Val Arg Val Gln Leu Ser Gly Lys Ile 450 455 460 caa gaa aac ata cca ttt tgg aaa cac gtc ggg ttt gaa tta ttg tcc 1440 Page 315 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Glu Asn Ile Pro Phe Trp Lys His Val Gly Phe Glu Leu Leu Ser 465 470 475 480 atg ggt aat gct aaa gaa tcg aag gct tta ctc aga gag att tca aac 1488 Met Gly Asn Ala Lys Glu Ser Lys Ala Leu Leu Arg Glu Ile Ser Asn 485 490 495 ttt agt aaa ggc gat gca gat gtc ctt gtt gac aga gtt gtt tcg tca 1536 Phe Ser Lys Gly Asp Ala Asp Val Leu Val Asp Arg Val Val Ser Ser 500 505 510 gat tct ttg gat ata gca caa ggt ata gat cta gtg aga gat att gat 1584 Asp Ser Leu Asp Ile Ala Gln Gly Ile Asp Leu Val Arg Asp Ile Asp 515 520 525 att gat aaa tta att caa ctt ggt gtg aaa ccc tta gaa tcg tca gca 1632 Ile Asp Lys Leu Ile Gln Leu Gly Val Lys Pro Leu Glu Ser Ser Ala 530 535 540 aag aga agt aaa aac acc gca gtt agc aaa gtt caa aag aga aaa gtt 1680 Lys Arg Ser Lys Asn Thr Ala Val Ser Lys Val Gln Lys Arg Lys Val 545 550 555 560 tta gag cta aag aag aaa aga aag att aaa cgc ctc gaa aaa ttt tta 1728 Leu Glu Leu Lys Lys Lys Arg Lys Ile Lys Arg Leu Glu Lys Phe Leu 565 570 575 caa ggt cgc gac acc tcc aaa tta cct gat cct gaa agg tgg ctg cca 1776 Gln Gly Arg Asp Thr Ser Lys Leu Pro Asp Pro Glu Arg Trp Leu Pro 580 585 590 tta aga gac agg tct act tat agg cca aag aaa aaa caa caa ggt gca 1824 Leu Arg Asp Arg Ser Thr Tyr Arg Pro Lys Lys Lys Gln Gln Gly Ala 595 600 605 aaa caa act caa ggt ggt gct atg aac aaa aaa tca gaa cag gcc ctt 1872 Lys Gln Thr Gln Gly Gly Ala Met Asn Lys Lys Ser Glu Gln Ala Leu 610 615 620 gac ata tca aag aaa ggg aag ccc act gtt aat aaa aag cct aag aac 1920 Asp Ile Ser Lys Lys Gly Lys Pro Thr Val Asn Lys Lys Pro Lys Asn 625 630 635 640 aag aag aag ggc cgt aaa tag 1941 Lys Lys Lys Gly Arg Lys 645 <210> 218 <211> 646 <212> PRT <213> Saccharomyces cerevisiae <400> 218 Met Lys Glu Ser Lys Lys Met Ala Lys Asp Asn Leu Thr Asn Leu Leu 1 5 10 15 Ser Gln Leu Asn Ile Gln Leu Ser Gln Asp Glu His Ser Gln Val Glu 20 25 30 Gln Thr Cys Val Lys Leu Leu Asp Ser Gly Cys Glu Asn Pro Ala Asp 35 40 45 Val Phe Arg Arg Cys Leu Val Ala Val Ile Gln Gln Asp Lys Tyr Gln Page 316 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 50 55 60 Lys Ala Leu His Tyr Leu Lys Lys Phe Lys His Ile Asp Asp Lys Tyr 65 70 75 80 Gly Arg Lys Phe Ala Leu Glu Lys Leu Tyr Ile Phe Tyr Lys Leu Asn 85 90 95 Met Pro Asp Glu Phe Asn Thr Leu Tyr Thr Ala Ile Ile Thr Asp Asp 100 105 110 Leu Asp Thr Val Leu Lys Lys Asp Ile Glu Ser Leu Arg Gly Ile Leu 115 120 125 His Val Arg Ala Gln Tyr Cys Tyr Lys Asn Gly Leu Tyr Gln Glu Ala 130 135 140 Phe Lys Ile Tyr Gln His Leu Ala Ser His Asn Glu Lys Asp Gln Asp 145 150 155 160 Ser Gln Ile Glu Leu Ser Cys Asn Glu Arg Val Pro Leu Ser Val Ala 165 170 175 Thr Glu Leu Met Asn Arg Ser Pro Leu Val Thr Pro Met Asp Glu Ser 180 185 190 Ser Tyr Asp Leu Leu Phe Asn Glu Ser Phe Ile Met Ala Ser Val Gly 195 200 205 Lys Tyr Asp Lys Ala Ile Glu Leu Leu Glu Lys Ala Leu Gln Gly Ala 210 215 220 Thr Asn Glu Gly Tyr Gln Asn Asp Ile Asn Thr Ile Lys Leu Gln Leu 225 230 235 240 Ser Phe Val Leu Gln Met Val Gly Lys Thr Ala Gln Ser Lys Glu Ile 245 250 255 Leu Lys Gly Leu Leu Gln Glu Leu Lys Ala Asp Ser Pro Phe Ser Leu 260 265 270 Ile Cys Gln Asn Asn Leu Asn Ala Phe Val Asp Phe Ser Lys Tyr Asn 275 280 285 Thr Asn Phe Asn Leu Leu Leu Arg Glu Leu Asn Val Glu Lys Leu Asn 290 295 300 Thr Phe Asn Leu Gln Thr Phe Thr His Glu Gln Trp Ser Asn Ile Gln 305 310 315 320 Arg Asn Val Leu Phe Leu Arg Leu Phe Asn Asn Val Lys Ile His Ser Page 317 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 325 330 335 Gln Glu Ser Leu Leu Ser Arg Thr Phe Asp Lys Tyr Ser Lys Leu Val 340 345 350 Asp Asn Val Thr Leu Glu Ser Tyr Lys Thr Gln Ala Lys Lys Leu Tyr 355 360 365 His His Thr Thr Lys Thr Ile Leu Ser Gly Thr Asp Gly Ser Thr Ile 370 375 380 Gly Ile Leu Leu Leu Thr Ile Gln Leu Leu Ile Ile Glu Lys Glu Trp 385 390 395 400 Glu Asn Ala Ile Arg Ile Gly Glu Leu Phe Leu Asn Glu Ser Trp Lys 405 410 415 Ser Ser Phe Glu Lys Phe Asn Asp Ser Gln Ala Ile Val Cys Tyr Ile 420 425 430 Leu Phe Glu Leu Tyr Lys Ile Lys Gly Arg Asn Asn Ser Lys Ser Val 435 440 445 Leu Leu Lys Lys Leu Gly Ser Val Arg Val Gln Leu Ser Gly Lys Ile 450 455 460 Gln Glu Asn Ile Pro Phe Trp Lys His Val Gly Phe Glu Leu Leu Ser 465 470 475 480 Met Gly Asn Ala Lys Glu Ser Lys Ala Leu Leu Arg Glu Ile Ser Asn 485 490 495 Phe Ser Lys Gly Asp Ala Asp Val Leu Val Asp Arg Val Val Ser Ser 500 505 510 Asp Ser Leu Asp Ile Ala Gln Gly Ile Asp Leu Val Arg Asp Ile Asp 515 520 525 Ile Asp Lys Leu Ile Gln Leu Gly Val Lys Pro Leu Glu Ser Ser Ala 530 535 540 Lys Arg Ser Lys Asn Thr Ala Val Ser Lys Val Gln Lys Arg Lys Val 545 550 555 560 Leu Glu Leu Lys Lys Lys Arg Lys Ile Lys Arg Leu Glu Lys Phe Leu 565 570 575 Gln Gly Arg Asp Thr Ser Lys Leu Pro Asp Pro Glu Arg Trp Leu Pro 580 585 590 Leu Arg Asp Arg Ser Thr Tyr Arg Pro Lys Lys Lys Gln Gln Gly Ala Page 318 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 595 600 605 Lys Gln Thr Gln Gly Gly Ala Met Asn Lys Lys Ser Glu Gln Ala Leu 610 615 620 Asp Ile Ser Lys Lys Gly Lys Pro Thr Val Asn Lys Lys Pro Lys Asn 625 630 635 640 Lys Lys Lys Gly Arg Lys 645 <210> 219 <211> 543 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(543) <400> 219 atg ttc gca act cgc tca ttc tgc cta agc tct tct tta ttc cgt ccg 48 Met Phe Ala Thr Arg Ser Phe Cys Leu Ser Ser Ser Leu Phe Arg Pro 1 5 10 15 gct gct caa ctg ttg cgc cct gct ggc cgc tct act tta cga aat gtt 96 Ala Ala Gln Leu Leu Arg Pro Ala Gly Arg Ser Thr Leu Arg Asn Val 20 25 30 tgg aga cgc tct att gca acc gaa cat ttg acc cag acg gag gct aat 144 Trp Arg Arg Ser Ile Ala Thr Glu His Leu Thr Gln Thr Glu Ala Asn 35 40 45 tct cgt ctt gct tcc cag cgt gtt cac cgt cca aat tct cct cat ttg 192 Ser Arg Leu Ala Ser Gln Arg Val His Arg Pro Asn Ser Pro His Leu 50 55 60 act atc tat gaa cct caa ttg act tgg tat cta tcc agt tta cat cgt 240 Thr Ile Tyr Glu Pro Gln Leu Thr Trp Tyr Leu Ser Ser Leu His Arg 65 70 75 80 atc act ggt tgt gtt gtc gcc ggt act ctt tat gct ttc gct atg ggc 288 Ile Thr Gly Cys Val Val Ala Gly Thr Leu Tyr Ala Phe Ala Met Gly 85 90 95 tac ttg gtg gct cct ctc gct gga tac tct ttg gat aca gct acc att 336 Tyr Leu Val Ala Pro Leu Ala Gly Tyr Ser Leu Asp Thr Ala Thr Ile 100 105 110 tct ggt ctt att cag caa gtt ccc acc tgg atc aaa gtt cct gct aag 384 Ser Gly Leu Ile Gln Gln Val Pro Thr Trp Ile Lys Val Pro Ala Lys 115 120 125 ttt gtt att tct tat cct ttg act ttc cac att ttt aac ggt att cgt 432 Phe Val Ile Ser Tyr Pro Leu Thr Phe His Ile Phe Asn Gly Ile Arg 130 135 140 cac ttg atc tgg gat acc acc aag gag tta agt cta aag ggt gtc tat 480 His Leu Ile Trp Asp Thr Thr Lys Glu Leu Ser Leu Lys Gly Val Tyr 145 150 155 160 cgt acc ggt tat gct gtt ctt gcc ctt tcc gtt ttg acc tct ggc tat 528 Arg Thr Gly Tyr Ala Val Leu Ala Leu Ser Val Leu Thr Ser Gly Tyr Page 319 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 165 170 175 ttt gcg atg att tag 543 Phe Ala Met Ile 180 <210> 220 <211> 180 <212> PRT <213> Saccharomyces cerevisiae <400> 220 Met Phe Ala Thr Arg Ser Phe Cys Leu Ser Ser Ser Leu Phe Arg Pro 1 5 10 15 Ala Ala Gln Leu Leu Arg Pro Ala Gly Arg Ser Thr Leu Arg Asn Val 20 25 30 Trp Arg Arg Ser Ile Ala Thr Glu His Leu Thr Gln Thr Glu Ala Asn 35 40 45 Ser Arg Leu Ala Ser Gln Arg Val His Arg Pro Asn Ser Pro His Leu 50 55 60 Thr Ile Tyr Glu Pro Gln Leu Thr Trp Tyr Leu Ser Ser Leu His Arg 65 70 75 80 Ile Thr Gly Cys Val Val Ala Gly Thr Leu Tyr Ala Phe Ala Met Gly 85 90 95 Tyr Leu Val Ala Pro Leu Ala Gly Tyr Ser Leu Asp Thr Ala Thr Ile 100 105 110 Ser Gly Leu Ile Gln Gln Val Pro Thr Trp Ile Lys Val Pro Ala Lys 115 120 125 Phe Val Ile Ser Tyr Pro Leu Thr Phe His Ile Phe Asn Gly Ile Arg 130 135 140 His Leu Ile Trp Asp Thr Thr Lys Glu Leu Ser Leu Lys Gly Val Tyr 145 150 155 160 Arg Thr Gly Tyr Ala Val Leu Ala Leu Ser Val Leu Thr Ser Gly Tyr 165 170 175 Phe Ala Met Ile 180 <210> 221 <211> 282 <212> DNA <213> Saccharomyces cerevisiae Page 320 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(282) <400> 221 atg gtc acc cca aga gaa cct aag aag aga acc act aga aag aag aag 48 Met Val Thr Pro Arg Glu Pro Lys Lys Arg Thr Thr Arg Lys Lys Lys 1 5 10 15 gac cca aat gcc cct aag agg gct ttg tcc gcc tac atg ttt ttc gct 96 Asp Pro Asn Ala Pro Lys Arg Ala Leu Ser Ala Tyr Met Phe Phe Ala 20 25 30 aac gaa aac aga gat att gtt cgt tct gaa aat cca gat atc aca ttt 144 Asn Glu Asn Arg Asp Ile Val Arg Ser Glu Asn Pro Asp Ile Thr Phe 35 40 45 gga caa gtc ggc aag aag ttg ggt gag aag tgg aag gct cta acg cca 192 Gly Gln Val Gly Lys Lys Leu Gly Glu Lys Trp Lys Ala Leu Thr Pro 50 55 60 gag gaa aag cag cct tac gag gcc aag gcc cag gcc gat aag aag aga 240 Glu Glu Lys Gln Pro Tyr Glu Ala Lys Ala Gln Ala Asp Lys Lys Arg 65 70 75 80 tat gaa tcc gaa aag gag tta tat aac gcc act ttg gct tag 282 Tyr Glu Ser Glu Lys Glu Leu Tyr Asn Ala Thr Leu Ala 85 90 <210> 222 <211> 93 <212> PRT <213> Saccharomyces cerevisiae <400> 222 Met Val Thr Pro Arg Glu Pro Lys Lys Arg Thr Thr Arg Lys Lys Lys 1 5 10 15 Asp Pro Asn Ala Pro Lys Arg Ala Leu Ser Ala Tyr Met Phe Phe Ala 20 25 30 Asn Glu Asn Arg Asp Ile Val Arg Ser Glu Asn Pro Asp Ile Thr Phe 35 40 45 Gly Gln Val Gly Lys Lys Leu Gly Glu Lys Trp Lys Ala Leu Thr Pro 50 55 60 Glu Glu Lys Gln Pro Tyr Glu Ala Lys Ala Gln Ala Asp Lys Lys Arg 65 70 75 80 Tyr Glu Ser Glu Lys Glu Leu Tyr Asn Ala Thr Leu Ala 85 90 <210> 223 <211> 1110 <212> DNA <213> Saccharomyces cerevisiae <220> Page 321 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <221> CDS <222> (1)..(1110) <400> 223 atg aat cag agc gat agc agc ttg atg gat tta cca ctg gag ata cat 48 Met Asn Gln Ser Asp Ser Ser Leu Met Asp Leu Pro Leu Glu Ile His 1 5 10 15 tta tca tta cta gag tac gtg cct aat gaa ctt cgt gct gtc aat aaa 96 Leu Ser Leu Leu Glu Tyr Val Pro Asn Glu Leu Arg Ala Val Asn Lys 20 25 30 tac ttc tac gtt ttg cat aac cac agc tat aag gag aag agt ttg gcg 144 Tyr Phe Tyr Val Leu His Asn His Ser Tyr Lys Glu Lys Ser Leu Ala 35 40 45 tgg ata gct gag gac aac tat ata tgg gcc gtt gtc aaa cat tca tta 192 Trp Ile Ala Glu Asp Asn Tyr Ile Trp Ala Val Val Lys His Ser Leu 50 55 60 tgt tta tat gtc aag agt ttg gac cca ctt cga cag cat gcc aga gaa 240 Cys Leu Tyr Val Lys Ser Leu Asp Pro Leu Arg Gln His Ala Arg Glu 65 70 75 80 atc att caa gaa acg aag gaa cca ggt ttt aat gtg cca ctg tgc atg 288 Ile Ile Gln Glu Thr Lys Glu Pro Gly Phe Asn Val Pro Leu Cys Met 85 90 95 act aaa tac atc gca gat tct tgg tat att gta tac aat gcg ctg caa 336 Thr Lys Tyr Ile Ala Asp Ser Trp Tyr Ile Val Tyr Asn Ala Leu Gln 100 105 110 tat cct gga aag ata att aat atg gga tgg gac aaa tat acc aaa agt 384 Tyr Pro Gly Lys Ile Ile Asn Met Gly Trp Asp Lys Tyr Thr Lys Ser 115 120 125 caa gat tca aat ggt tct gat tct acc agt aac ttt aat agt cgg ccc 432 Gln Asp Ser Asn Gly Ser Asp Ser Thr Ser Asn Phe Asn Ser Arg Pro 130 135 140 aag gaa aga act ctt atg cag tcg ttg aca gct tta cct gtt aac ttt 480 Lys Glu Arg Thr Leu Met Gln Ser Leu Thr Ala Leu Pro Val Asn Phe 145 150 155 160 tgg tcc agg agg aag gac gag cct aca ccg gta aac gtt tgg ttt tat 528 Trp Ser Arg Arg Lys Asp Glu Pro Thr Pro Val Asn Val Trp Phe Tyr 165 170 175 gta aaa aat gcg cac gtt gcc aga tac ata ccg aaa att att acg gaa 576 Val Lys Asn Ala His Val Ala Arg Tyr Ile Pro Lys Ile Ile Thr Glu 180 185 190 ata ggc ata tgc aac tat ggg ccg aag cag atc gtg gca agt gca gga 624 Ile Gly Ile Cys Asn Tyr Gly Pro Lys Gln Ile Val Ala Ser Ala Gly 195 200 205 tat atc aac gaa ttg ata aca tct gaa gga ata tac tgt gtt aac cta 672 Tyr Ile Asn Glu Leu Ile Thr Ser Glu Gly Ile Tyr Cys Val Asn Leu 210 215 220 ggc cac ctt ccc agg cta tac gat gag caa att ttt gaa ggc act gga 720 Gly His Leu Pro Arg Leu Tyr Asp Glu Gln Ile Phe Glu Gly Thr Gly 225 230 235 240 acg aca cat ctt ccc ctg gaa ctg aaa gct atc gac agg aca gat tca 768 Thr Thr His Leu Pro Leu Glu Leu Lys Ala Ile Asp Arg Thr Asp Ser 245 250 255 Page 322 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gat gtt tgt atc aat ggt gat tta gtt cta ctc ggt tat gac ttt att 816 Asp Val Cys Ile Asn Gly Asp Leu Val Leu Leu Gly Tyr Asp Phe Ile 260 265 270 cca tat cag ata tcg aag ccg tgg tta ctc ttt aga atc gaa ccc gta 864 Pro Tyr Gln Ile Ser Lys Pro Trp Leu Leu Phe Arg Ile Glu Pro Val 275 280 285 aat agc att gaa gca atc ttc aac tat agt gaa tgt tct ttt tca tac 912 Asn Ser Ile Glu Ala Ile Phe Asn Tyr Ser Glu Cys Ser Phe Ser Tyr 290 295 300 cag ttt gca tgg agt ttg gcc tgc tta caa tct gaa gag aaa att tca 960 Gln Phe Ala Trp Ser Leu Ala Cys Leu Gln Ser Glu Glu Lys Ile Ser 305 310 315 320 ttt cct aga gac acg ata att ggg cac ggt tta cct tac aag cca tcc 1008 Phe Pro Arg Asp Thr Ile Ile Gly His Gly Leu Pro Tyr Lys Pro Ser 325 330 335 aaa ttg ata aga att ttc gtc tac aag cat ccg gaa caa aag caa gat 1056 Lys Leu Ile Arg Ile Phe Val Tyr Lys His Pro Glu Gln Lys Gln Asp 340 345 350 ctt ggt caa gaa ata gca ttg ccc aac tgg aat acc cct tat ctt cga 1104 Leu Gly Gln Glu Ile Ala Leu Pro Asn Trp Asn Thr Pro Tyr Leu Arg 355 360 365 aga tga 1110 Arg <210> 224 <211> 369 <212> PRT <213> Saccharomyces cerevisiae <400> 224 Met Asn Gln Ser Asp Ser Ser Leu Met Asp Leu Pro Leu Glu Ile His 1 5 10 15 Leu Ser Leu Leu Glu Tyr Val Pro Asn Glu Leu Arg Ala Val Asn Lys 20 25 30 Tyr Phe Tyr Val Leu His Asn His Ser Tyr Lys Glu Lys Ser Leu Ala 35 40 45 Trp Ile Ala Glu Asp Asn Tyr Ile Trp Ala Val Val Lys His Ser Leu 50 55 60 Cys Leu Tyr Val Lys Ser Leu Asp Pro Leu Arg Gln His Ala Arg Glu 65 70 75 80 Ile Ile Gln Glu Thr Lys Glu Pro Gly Phe Asn Val Pro Leu Cys Met 85 90 95 Thr Lys Tyr Ile Ala Asp Ser Trp Tyr Ile Val Tyr Asn Ala Leu Gln 100 105 110 Page 323 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Tyr Pro Gly Lys Ile Ile Asn Met Gly Trp Asp Lys Tyr Thr Lys Ser 115 120 125 Gln Asp Ser Asn Gly Ser Asp Ser Thr Ser Asn Phe Asn Ser Arg Pro 130 135 140 Lys Glu Arg Thr Leu Met Gln Ser Leu Thr Ala Leu Pro Val Asn Phe 145 150 155 160 Trp Ser Arg Arg Lys Asp Glu Pro Thr Pro Val Asn Val Trp Phe Tyr 165 170 175 Val Lys Asn Ala His Val Ala Arg Tyr Ile Pro Lys Ile Ile Thr Glu 180 185 190 Ile Gly Ile Cys Asn Tyr Gly Pro Lys Gln Ile Val Ala Ser Ala Gly 195 200 205 Tyr Ile Asn Glu Leu Ile Thr Ser Glu Gly Ile Tyr Cys Val Asn Leu 210 215 220 Gly His Leu Pro Arg Leu Tyr Asp Glu Gln Ile Phe Glu Gly Thr Gly 225 230 235 240 Thr Thr His Leu Pro Leu Glu Leu Lys Ala Ile Asp Arg Thr Asp Ser 245 250 255 Asp Val Cys Ile Asn Gly Asp Leu Val Leu Leu Gly Tyr Asp Phe Ile 260 265 270 Pro Tyr Gln Ile Ser Lys Pro Trp Leu Leu Phe Arg Ile Glu Pro Val 275 280 285 Asn Ser Ile Glu Ala Ile Phe Asn Tyr Ser Glu Cys Ser Phe Ser Tyr 290 295 300 Gln Phe Ala Trp Ser Leu Ala Cys Leu Gln Ser Glu Glu Lys Ile Ser 305 310 315 320 Phe Pro Arg Asp Thr Ile Ile Gly His Gly Leu Pro Tyr Lys Pro Ser 325 330 335 Lys Leu Ile Arg Ile Phe Val Tyr Lys His Pro Glu Gln Lys Gln Asp 340 345 350 Leu Gly Gln Glu Ile Ala Leu Pro Asn Trp Asn Thr Pro Tyr Leu Arg 355 360 365 Arg Page 324 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 225 <211> 333 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(333) <400> 225 atg tct tca caa ata att gat cgt cca aaa cat gaa ctc tct aga gca 48 Met Ser Ser Gln Ile Ile Asp Arg Pro Lys His Glu Leu Ser Arg Ala 1 5 10 15 gaa tta gag gaa cta gaa gaa ttt gaa ttc aaa cat ggt cca atg tcc 96 Glu Leu Glu Glu Leu Glu Glu Phe Glu Phe Lys His Gly Pro Met Ser 20 25 30 ctg ata aat gat gct atg gtg aca aga aca cct gtg ata atc tca tta 144 Leu Ile Asn Asp Ala Met Val Thr Arg Thr Pro Val Ile Ile Ser Leu 35 40 45 aga aac aat cat aaa ata ata gcg aga gtg aaa gct ttc gac agg cat 192 Arg Asn Asn His Lys Ile Ile Ala Arg Val Lys Ala Phe Asp Arg His 50 55 60 tgt aat atg gtt tta gaa aat gtg aag gag ctt tgg aca gag aag aag 240 Cys Asn Met Val Leu Glu Asn Val Lys Glu Leu Trp Thr Glu Lys Lys 65 70 75 80 ggc aaa aat gta att aat cgg gaa aga ttc ata agt aaa cta ttc tta 288 Gly Lys Asn Val Ile Asn Arg Glu Arg Phe Ile Ser Lys Leu Phe Leu 85 90 95 aga ggt gat tca gtt atc gtt gtg tta aaa acc cct gtt gag taa 333 Arg Gly Asp Ser Val Ile Val Val Leu Lys Thr Pro Val Glu 100 105 110 <210> 226 <211> 110 <212> PRT <213> Saccharomyces cerevisiae <400> 226 Met Ser Ser Gln Ile Ile Asp Arg Pro Lys His Glu Leu Ser Arg Ala 1 5 10 15 Glu Leu Glu Glu Leu Glu Glu Phe Glu Phe Lys His Gly Pro Met Ser 20 25 30 Leu Ile Asn Asp Ala Met Val Thr Arg Thr Pro Val Ile Ile Ser Leu 35 40 45 Arg Asn Asn His Lys Ile Ile Ala Arg Val Lys Ala Phe Asp Arg His 50 55 60 Cys Asn Met Val Leu Glu Asn Val Lys Glu Leu Trp Thr Glu Lys Lys 65 70 75 80 Gly Lys Asn Val Ile Asn Arg Glu Arg Phe Ile Ser Lys Leu Phe Leu Page 325 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Arg Gly Asp Ser Val Ile Val Val Leu Lys Thr Pro Val Glu 100 105 110 <210> 227 <211> 2184 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2184) <400> 227 atg aat gat tgg cat gag ttc aat gcc gcg ata aag tca ata tat tgt 48 Met Asn Asp Trp His Glu Phe Asn Ala Ala Ile Lys Ser Ile Tyr Cys 1 5 10 15 aat gca gaa ggt gac tca agc agt ata att aat aga ttg gtt ggc ttg 96 Asn Ala Glu Gly Asp Ser Ser Ser Ile Ile Asn Arg Leu Val Gly Leu 20 25 30 gca atg aaa agc gaa gat tcc act ttt att gag gcc gtt tta gtt ttg 144 Ala Met Lys Ser Glu Asp Ser Thr Phe Ile Glu Ala Val Leu Val Leu 35 40 45 aaa gaa aat gtg tcg aaa gta gat aaa caa tta aga ttt tta tgg ctt 192 Lys Glu Asn Val Ser Lys Val Asp Lys Gln Leu Arg Phe Leu Trp Leu 50 55 60 act tca act att aat tca agg ttt tat ccc cct ata cct atc tca gaa 240 Thr Ser Thr Ile Asn Ser Arg Phe Tyr Pro Pro Ile Pro Ile Ser Glu 65 70 75 80 gcc tca ccg gtt tct tgg aat aaa acc gaa tat tgc gca cct ggt act 288 Ala Ser Pro Val Ser Trp Asn Lys Thr Glu Tyr Cys Ala Pro Gly Thr 85 90 95 gaa gaa cta caa agg cgt tat cca ggg aga gcc aag tta cag aat gaa 336 Glu Glu Leu Gln Arg Arg Tyr Pro Gly Arg Ala Lys Leu Gln Asn Glu 100 105 110 gaa gac tat tca ggc gga ata gaa caa tgc cga gat gtg cca gat tgc 384 Glu Asp Tyr Ser Gly Gly Ile Glu Gln Cys Arg Asp Val Pro Asp Cys 115 120 125 tca tta gtt gct tct cta att aat ctt agg tct aag aac ttg aat ctc 432 Ser Leu Val Ala Ser Leu Ile Asn Leu Arg Ser Lys Asn Leu Asn Leu 130 135 140 cct cta att aaa caa ata tca tca act aaa tat cac gtc aat tta agt 480 Pro Leu Ile Lys Gln Ile Ser Ser Thr Lys Tyr His Val Asn Leu Ser 145 150 155 160 ttt aac gga agc aac aaa agg cta gtg aca gta gat att tcg cag atc 528 Phe Asn Gly Ser Asn Lys Arg Leu Val Thr Val Asp Ile Ser Gln Ile 165 170 175 cca acc tca gtg gat ggc aaa caa ctt tct tta aag agt aac gat att 576 Pro Thr Ser Val Asp Gly Lys Gln Leu Ser Leu Lys Ser Asn Asp Ile 180 185 190 tcg gac aaa att gga gag ctt gca tta ctg ctt gtt tct aaa gga aca 624 Ser Asp Lys Ile Gly Glu Leu Ala Leu Leu Leu Val Ser Lys Gly Thr Page 326 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 195 200 205 tat tcc acg gat ggc tca aat att agt ata gat act tac cgc tta agt 672 Tyr Ser Thr Asp Gly Ser Asn Ile Ser Ile Asp Thr Tyr Arg Leu Ser 210 215 220 ggc ttc tta cca gag ata aca caa gta aac agc tat cct ttc gaa aaa 720 Gly Phe Leu Pro Glu Ile Thr Gln Val Asn Ser Tyr Pro Phe Glu Lys 225 230 235 240 tta tgg aag ttt cac aaa tct aat tta tgt ctg atg ggc gct ggc acc 768 Leu Trp Lys Phe His Lys Ser Asn Leu Cys Leu Met Gly Ala Gly Thr 245 250 255 ggg aat cgt tcc aat gac atg ata aag ccc cta gtt gag aac cat gat 816 Gly Asn Arg Ser Asn Asp Met Ile Lys Pro Leu Val Glu Asn His Asp 260 265 270 tac tct ata att gat atc aca tat gat tct agg cta gta aaa ttg cga 864 Tyr Ser Ile Ile Asp Ile Thr Tyr Asp Ser Arg Leu Val Lys Leu Arg 275 280 285 gat ccg agg aac tcg gca cta aat gtt gaa atc agc tat gaa cag tat 912 Asp Pro Arg Asn Ser Ala Leu Asn Val Glu Ile Ser Tyr Glu Gln Tyr 290 295 300 tta aaa aat ttc aaa caa ctt tat ctt aat tgg aac caa gaa aaa tta 960 Leu Lys Asn Phe Lys Gln Leu Tyr Leu Asn Trp Asn Gln Glu Lys Leu 305 310 315 320 ttc aaa cgt tct cag gta ctt cat ttt cgg tac gat act tca cgc tac 1008 Phe Lys Arg Ser Gln Val Leu His Phe Arg Tyr Asp Thr Ser Arg Tyr 325 330 335 aat aaa ttt tct atc gtt gca gat aaa cct tta ttt cac ctg gta aac 1056 Asn Lys Phe Ser Ile Val Ala Asp Lys Pro Leu Phe His Leu Val Asn 340 345 350 aat tct aaa gtg aca gag acg gta tgg tta ttg cta gaa tcc cat ttg 1104 Asn Ser Lys Val Thr Glu Thr Val Trp Leu Leu Leu Glu Ser His Leu 355 360 365 caa gat gaa ggc agc caa gaa aat cgg tca gtt tcc ttt ttg aat gag 1152 Gln Asp Glu Gly Ser Gln Glu Asn Arg Ser Val Ser Phe Leu Asn Glu 370 375 380 gct ccc gaa tgc ata att tgt cca att gaa cct cca gta gaa tgc ggt 1200 Ala Pro Glu Cys Ile Ile Cys Pro Ile Glu Pro Pro Val Glu Cys Gly 385 390 395 400 ggc aat cac att gga ctt cag ctg gta aag ttg aga tta gat gct gag 1248 Gly Asn His Ile Gly Leu Gln Leu Val Lys Leu Arg Leu Asp Ala Glu 405 410 415 act gag agg tta ttg tat tgt tat tca aca aca aac aac aat ttc agt 1296 Thr Glu Arg Leu Leu Tyr Cys Tyr Ser Thr Thr Asn Asn Asn Phe Ser 420 425 430 att cac tct ttc tca gtt gtg aag gaa ata tgt ttt caa aga ttg aaa 1344 Ile His Ser Phe Ser Val Val Lys Glu Ile Cys Phe Gln Arg Leu Lys 435 440 445 gat aca aaa agt ctt ttt gcc aaa gtc ctt ttc tct ttt cct tat gaa 1392 Asp Thr Lys Ser Leu Phe Ala Lys Val Leu Phe Ser Phe Pro Tyr Glu 450 455 460 ata gag gga aaa gcc tca ttt gat act tgt aat ttt ttt caa aat ccg 1440 Ile Glu Gly Lys Ala Ser Phe Asp Thr Cys Asn Phe Phe Gln Asn Pro Page 327 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 465 470 475 480 act ttt gag ttg gaa gtt cac tct gaa caa gat tat caa gta ctt atg 1488 Thr Phe Glu Leu Glu Val His Ser Glu Gln Asp Tyr Gln Val Leu Met 485 490 495 gac gcc gca tgt atc tca act agc tca cat gat tta att aac atc caa 1536 Asp Ala Ala Cys Ile Ser Thr Ser Ser His Asp Leu Ile Asn Ile Gln 500 505 510 gta tat tac ttt aat gac tat gaa ttg ata aag cca ata atg ttt gat 1584 Val Tyr Tyr Phe Asn Asp Tyr Glu Leu Ile Lys Pro Ile Met Phe Asp 515 520 525 aac cac tat cag ccc ggg cag ggc ctt aaa caa gac gtg ccc atc tta 1632 Asn His Tyr Gln Pro Gly Gln Gly Leu Lys Gln Asp Val Pro Ile Leu 530 535 540 act aat gtc aaa tat atg att gta tgc tca act tac ggc cct cca gcc 1680 Thr Asn Val Lys Tyr Met Ile Val Cys Ser Thr Tyr Gly Pro Pro Ala 545 550 555 560 tca acg gaa ttt gaa tta ctt gcc tcg ata cgg tta tcc tct tca tgg 1728 Ser Thr Glu Phe Glu Leu Leu Ala Ser Ile Arg Leu Ser Ser Ser Trp 565 570 575 agg tta ata tct gga ata act tta cgg agt gtt aac ttg ata tac ggt 1776 Arg Leu Ile Ser Gly Ile Thr Leu Arg Ser Val Asn Leu Ile Tyr Gly 580 585 590 act tat cca tat cat tgt cgc aac agg ttc cat tgg aag gaa act tca 1824 Thr Tyr Pro Tyr His Cys Arg Asn Arg Phe His Trp Lys Glu Thr Ser 595 600 605 gac aaa ctt aaa att cag atg act ttg cca acc aaa aag tat tct acg 1872 Asp Lys Leu Lys Ile Gln Met Thr Leu Pro Thr Lys Lys Tyr Ser Thr 610 615 620 aac aaa ctt ttt ata cgt gta gta ccc gtg gaa tca tca gca cga tta 1920 Asn Lys Leu Phe Ile Arg Val Val Pro Val Glu Ser Ser Ala Arg Leu 625 630 635 640 agg atg cga tgt aat att ttc gag cct gaa tca gct ctc tgt gtt tat 1968 Arg Met Arg Cys Asn Ile Phe Glu Pro Glu Ser Ala Leu Cys Val Tyr 645 650 655 gaa tgt caa gag tat agg aca tgt cca tct ggg ggc atc gtt ata cct 2016 Glu Cys Gln Glu Tyr Arg Thr Cys Pro Ser Gly Gly Ile Val Ile Pro 660 665 670 gat ctg gaa gtc tct cgt act aac att gtt gta ttg atg ata gaa aga 2064 Asp Leu Glu Val Ser Arg Thr Asn Ile Val Val Leu Met Ile Glu Arg 675 680 685 agt gta cct att tcc agt tgt tta cct acg gaa gga caa ttg gat gaa 2112 Ser Val Pro Ile Ser Ser Cys Leu Pro Thr Glu Gly Gln Leu Asp Glu 690 695 700 ttg gag ttg ttt gtt ggg tcc agt caa aaa atc aga att gaa aaa tac 2160 Leu Glu Leu Phe Val Gly Ser Ser Gln Lys Ile Arg Ile Glu Lys Tyr 705 710 715 720 tcc gat gat gtg ata cca aaa taa 2184 Ser Asp Asp Val Ile Pro Lys 725 <210> 228 Page 328 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 727 <212> PRT <213> Saccharomyces cerevisiae <400> 228 Met Asn Asp Trp His Glu Phe Asn Ala Ala Ile Lys Ser Ile Tyr Cys 1 5 10 15 Asn Ala Glu Gly Asp Ser Ser Ser Ile Ile Asn Arg Leu Val Gly Leu 20 25 30 Ala Met Lys Ser Glu Asp Ser Thr Phe Ile Glu Ala Val Leu Val Leu 35 40 45 Lys Glu Asn Val Ser Lys Val Asp Lys Gln Leu Arg Phe Leu Trp Leu 50 55 60 Thr Ser Thr Ile Asn Ser Arg Phe Tyr Pro Pro Ile Pro Ile Ser Glu 65 70 75 80 Ala Ser Pro Val Ser Trp Asn Lys Thr Glu Tyr Cys Ala Pro Gly Thr 85 90 95 Glu Glu Leu Gln Arg Arg Tyr Pro Gly Arg Ala Lys Leu Gln Asn Glu 100 105 110 Glu Asp Tyr Ser Gly Gly Ile Glu Gln Cys Arg Asp Val Pro Asp Cys 115 120 125 Ser Leu Val Ala Ser Leu Ile Asn Leu Arg Ser Lys Asn Leu Asn Leu 130 135 140 Pro Leu Ile Lys Gln Ile Ser Ser Thr Lys Tyr His Val Asn Leu Ser 145 150 155 160 Phe Asn Gly Ser Asn Lys Arg Leu Val Thr Val Asp Ile Ser Gln Ile 165 170 175 Pro Thr Ser Val Asp Gly Lys Gln Leu Ser Leu Lys Ser Asn Asp Ile 180 185 190 Ser Asp Lys Ile Gly Glu Leu Ala Leu Leu Leu Val Ser Lys Gly Thr 195 200 205 Tyr Ser Thr Asp Gly Ser Asn Ile Ser Ile Asp Thr Tyr Arg Leu Ser 210 215 220 Gly Phe Leu Pro Glu Ile Thr Gln Val Asn Ser Tyr Pro Phe Glu Lys 225 230 235 240 Leu Trp Lys Phe His Lys Ser Asn Leu Cys Leu Met Gly Ala Gly Thr 245 250 255 Page 329 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Asn Arg Ser Asn Asp Met Ile Lys Pro Leu Val Glu Asn His Asp 260 265 270 Tyr Ser Ile Ile Asp Ile Thr Tyr Asp Ser Arg Leu Val Lys Leu Arg 275 280 285 Asp Pro Arg Asn Ser Ala Leu Asn Val Glu Ile Ser Tyr Glu Gln Tyr 290 295 300 Leu Lys Asn Phe Lys Gln Leu Tyr Leu Asn Trp Asn Gln Glu Lys Leu 305 310 315 320 Phe Lys Arg Ser Gln Val Leu His Phe Arg Tyr Asp Thr Ser Arg Tyr 325 330 335 Asn Lys Phe Ser Ile Val Ala Asp Lys Pro Leu Phe His Leu Val Asn 340 345 350 Asn Ser Lys Val Thr Glu Thr Val Trp Leu Leu Leu Glu Ser His Leu 355 360 365 Gln Asp Glu Gly Ser Gln Glu Asn Arg Ser Val Ser Phe Leu Asn Glu 370 375 380 Ala Pro Glu Cys Ile Ile Cys Pro Ile Glu Pro Pro Val Glu Cys Gly 385 390 395 400 Gly Asn His Ile Gly Leu Gln Leu Val Lys Leu Arg Leu Asp Ala Glu 405 410 415 Thr Glu Arg Leu Leu Tyr Cys Tyr Ser Thr Thr Asn Asn Asn Phe Ser 420 425 430 Ile His Ser Phe Ser Val Val Lys Glu Ile Cys Phe Gln Arg Leu Lys 435 440 445 Asp Thr Lys Ser Leu Phe Ala Lys Val Leu Phe Ser Phe Pro Tyr Glu 450 455 460 Ile Glu Gly Lys Ala Ser Phe Asp Thr Cys Asn Phe Phe Gln Asn Pro 465 470 475 480 Thr Phe Glu Leu Glu Val His Ser Glu Gln Asp Tyr Gln Val Leu Met 485 490 495 Asp Ala Ala Cys Ile Ser Thr Ser Ser His Asp Leu Ile Asn Ile Gln 500 505 510 Val Tyr Tyr Phe Asn Asp Tyr Glu Leu Ile Lys Pro Ile Met Phe Asp 515 520 525 Page 330 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn His Tyr Gln Pro Gly Gln Gly Leu Lys Gln Asp Val Pro Ile Leu 530 535 540 Thr Asn Val Lys Tyr Met Ile Val Cys Ser Thr Tyr Gly Pro Pro Ala 545 550 555 560 Ser Thr Glu Phe Glu Leu Leu Ala Ser Ile Arg Leu Ser Ser Ser Trp 565 570 575 Arg Leu Ile Ser Gly Ile Thr Leu Arg Ser Val Asn Leu Ile Tyr Gly 580 585 590 Thr Tyr Pro Tyr His Cys Arg Asn Arg Phe His Trp Lys Glu Thr Ser 595 600 605 Asp Lys Leu Lys Ile Gln Met Thr Leu Pro Thr Lys Lys Tyr Ser Thr 610 615 620 Asn Lys Leu Phe Ile Arg Val Val Pro Val Glu Ser Ser Ala Arg Leu 625 630 635 640 Arg Met Arg Cys Asn Ile Phe Glu Pro Glu Ser Ala Leu Cys Val Tyr 645 650 655 Glu Cys Gln Glu Tyr Arg Thr Cys Pro Ser Gly Gly Ile Val Ile Pro 660 665 670 Asp Leu Glu Val Ser Arg Thr Asn Ile Val Val Leu Met Ile Glu Arg 675 680 685 Ser Val Pro Ile Ser Ser Cys Leu Pro Thr Glu Gly Gln Leu Asp Glu 690 695 700 Leu Glu Leu Phe Val Gly Ser Ser Gln Lys Ile Arg Ile Glu Lys Tyr 705 710 715 720 Ser Asp Asp Val Ile Pro Lys 725 <210> 229 <211> 2223 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2223) <400> 229 atg gat aga ggc agg tgg tgt ttc ctc gtg tcc gta tca agc aga ata 48 Met Asp Arg Gly Arg Trp Cys Phe Leu Val Ser Val Ser Ser Arg Ile 1 5 10 15 Page 331 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atg aat ctg caa gaa cta tta gcg aaa gta ccg ctg ttg tta tcg tat 96 Met Asn Leu Gln Glu Leu Leu Ala Lys Val Pro Leu Leu Leu Ser Tyr 20 25 30 ccg acc att att cta tcc agt aat ctg atc gta cct tcc cat aat gat 144 Pro Thr Ile Ile Leu Ser Ser Asn Leu Ile Val Pro Ser His Asn Asp 35 40 45 ctc ata tca cga gca gcc tct aca tca gca gca gag tat gct gac gaa 192 Leu Ile Ser Arg Ala Ala Ser Thr Ser Ala Ala Glu Tyr Ala Asp Glu 50 55 60 aag cta ata ttt ttc agt aca gat cat gcc atc aga ctg att ttt ctg 240 Lys Leu Ile Phe Phe Ser Thr Asp His Ala Ile Arg Leu Ile Phe Leu 65 70 75 80 cca acc ttc gta gct tct tcc ttt aac cta ttt gcg cac tat ttt aac 288 Pro Thr Phe Val Ala Ser Ser Phe Asn Leu Phe Ala His Tyr Phe Asn 85 90 95 ttc atc aat tac tct agc cga agg aag tat tat gtt tta ttt act gca 336 Phe Ile Asn Tyr Ser Ser Arg Arg Lys Tyr Tyr Val Leu Phe Thr Ala 100 105 110 att tat ttc cta tcc ata ttg act gcg att ttc cat cca att cag tca 384 Ile Tyr Phe Leu Ser Ile Leu Thr Ala Ile Phe His Pro Ile Gln Ser 115 120 125 aca tgc atc act cta ttg att atc aag ctc ctg act acc gct gat gag 432 Thr Cys Ile Thr Leu Leu Ile Ile Lys Leu Leu Thr Thr Ala Asp Glu 130 135 140 tct tcg cca aaa att gcc ctc aat ttc aag acc att ttg aaa aca ttt 480 Ser Ser Pro Lys Ile Ala Leu Asn Phe Lys Thr Ile Leu Lys Thr Phe 145 150 155 160 gtt ccc ttt att act tta aca tta gtt ata ttg cgt tgg gat cct tct 528 Val Pro Phe Ile Thr Leu Thr Leu Val Ile Leu Arg Trp Asp Pro Ser 165 170 175 ttt gat gcc agc tca gga gat gtg aac aaa att tct acg tct ttg gcc 576 Phe Asp Ala Ser Ser Gly Asp Val Asn Lys Ile Ser Thr Ser Leu Ala 180 185 190 gca tat gct ctc tta ata tta acg cta aga tat gca tca ccg ctg ata 624 Ala Tyr Ala Leu Leu Ile Leu Thr Leu Arg Tyr Ala Ser Pro Leu Ile 195 200 205 tta tcg acg tta tca agt agc ata ggt gtt gtt tcc aaa gac acc agc 672 Leu Ser Thr Leu Ser Ser Ser Ile Gly Val Val Ser Lys Asp Thr Ser 210 215 220 gtc gca cag cat tcg ata agt aga aat aag aga ttt ccg cta att ctc 720 Val Ala Gln His Ser Ile Ser Arg Asn Lys Arg Phe Pro Leu Ile Leu 225 230 235 240 gtg tta ccg att ttt tcc ttt gtt ctt ttg tat cta atg act ata gtt 768 Val Leu Pro Ile Phe Ser Phe Val Leu Leu Tyr Leu Met Thr Ile Val 245 250 255 aac aag act tac aat atc cag tta tta atg gta ttt gtg ttt ttt gga 816 Asn Lys Thr Tyr Asn Ile Gln Leu Leu Met Val Phe Val Phe Phe Gly 260 265 270 tgt ctg tcc att ttc ttt tta tcg tta aaa gat ttg ttc aca gag gat 864 Cys Leu Ser Ile Phe Phe Leu Ser Leu Lys Asp Leu Phe Thr Glu Asp 275 280 285 Page 332 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gga aat caa aag aag gga ggc cag gag gat gaa tat tgt cgt atg ttt 912 Gly Asn Gln Lys Lys Gly Gly Gln Glu Asp Glu Tyr Cys Arg Met Phe 290 295 300 gac ata aag tac atg att tcc tat tta tgg ctg aca agg ttc acc att 960 Asp Ile Lys Tyr Met Ile Ser Tyr Leu Trp Leu Thr Arg Phe Thr Ile 305 310 315 320 tta ttg aca ggc ata atg gct att gta gta cat ttt tta tcg ttt aat 1008 Leu Leu Thr Gly Ile Met Ala Ile Val Val His Phe Leu Ser Phe Asn 325 330 335 gaa att act tct tcc atc aaa act gat ttg tta agt tta ctt ttc gtc 1056 Glu Ile Thr Ser Ser Ile Lys Thr Asp Leu Leu Ser Leu Leu Phe Val 340 345 350 gta gtg gca gaa tat gtt tcc agt ttc tct aac aaa caa cct gat tcg 1104 Val Val Ala Glu Tyr Val Ser Ser Phe Ser Asn Lys Gln Pro Asp Ser 355 360 365 cac tcc cat aat cat gca cat cac cat tcc cat cta acc gat tca ttg 1152 His Ser His Asn His Ala His His His Ser His Leu Thr Asp Ser Leu 370 375 380 cct ctc gaa aat gaa agt atg ttc aaa caa atg gca ttg aat aag gac 1200 Pro Leu Glu Asn Glu Ser Met Phe Lys Gln Met Ala Leu Asn Lys Asp 385 390 395 400 acc agg tcc att ttt tcg ttt tta ttg ttg aat acc gct ttc atg ttt 1248 Thr Arg Ser Ile Phe Ser Phe Leu Leu Leu Asn Thr Ala Phe Met Phe 405 410 415 gta caa ctt tta tat tcc ttt cgt tcc aaa tca ttg ggc tta tta tct 1296 Val Gln Leu Leu Tyr Ser Phe Arg Ser Lys Ser Leu Gly Leu Leu Ser 420 425 430 gat tcg ttg cat atg gcc tta gat tgc aca tct ttg ctc tta ggt cta 1344 Asp Ser Leu His Met Ala Leu Asp Cys Thr Ser Leu Leu Leu Gly Leu 435 440 445 att gct ggt gta ttg acc aag aaa cca gca agt gat aaa ttc cct ttc 1392 Ile Ala Gly Val Leu Thr Lys Lys Pro Ala Ser Asp Lys Phe Pro Phe 450 455 460 ggt cta aat tat ctt ggt acc ttg gca ggt ttc acc aat ggt gtt ctg 1440 Gly Leu Asn Tyr Leu Gly Thr Leu Ala Gly Phe Thr Asn Gly Val Leu 465 470 475 480 tta ctc ggc ata gtg tgc ggt atc ttt gtg gag gca att gag aga att 1488 Leu Leu Gly Ile Val Cys Gly Ile Phe Val Glu Ala Ile Glu Arg Ile 485 490 495 ttc aac ccc att cat ctt cat gca aca aat gag ttg ttg gtt gtt gct 1536 Phe Asn Pro Ile His Leu His Ala Thr Asn Glu Leu Leu Val Val Ala 500 505 510 acg tta ggc tta tta gtg aac ctt gta ggt ttg ttt gcc ttc gac cat 1584 Thr Leu Gly Leu Leu Val Asn Leu Val Gly Leu Phe Ala Phe Asp His 515 520 525 ggt gca cat gat cat ggt ggt act gat aat gaa aac atg aag ggg att 1632 Gly Ala His Asp His Gly Gly Thr Asp Asn Glu Asn Met Lys Gly Ile 530 535 540 ttt tta cat ata ttg gca gat aca tta ggt tct gtt ggc gtt gtt att 1680 Phe Leu His Ile Leu Ala Asp Thr Leu Gly Ser Val Gly Val Val Ile 545 550 555 560 Page 333 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tcg acg tta tta atc aag tta aca cac tgg cca att ttt gat ccg atc 1728 Ser Thr Leu Leu Ile Lys Leu Thr His Trp Pro Ile Phe Asp Pro Ile 565 570 575 gcc tct tta tta att ggt tcc ttg att tta ctt agc gct ctg ccc ctg 1776 Ala Ser Leu Leu Ile Gly Ser Leu Ile Leu Leu Ser Ala Leu Pro Leu 580 585 590 cta aaa tct act tcc gca aat att tta cta aga ctg gat gac aag aag 1824 Leu Lys Ser Thr Ser Ala Asn Ile Leu Leu Arg Leu Asp Asp Lys Lys 595 600 605 cat aat cta gta aag agt gcg cta aac cag att tca acg acg cca gga 1872 His Asn Leu Val Lys Ser Ala Leu Asn Gln Ile Ser Thr Thr Pro Gly 610 615 620 atc aca ggt tat aca act cct aga ttt tgg ccg aca gag tca ggc agt 1920 Ile Thr Gly Tyr Thr Thr Pro Arg Phe Trp Pro Thr Glu Ser Gly Ser 625 630 635 640 tcc ggg cat tca cat gca cac acg cat tct cat gca gag aat cat agc 1968 Ser Gly His Ser His Ala His Thr His Ser His Ala Glu Asn His Ser 645 650 655 cat gag cat cat cat gat cag aaa aac ggt tca caa gaa cac ccg agc 2016 His Glu His His His Asp Gln Lys Asn Gly Ser Gln Glu His Pro Ser 660 665 670 ttg gtg ggc tat att cat gta cag tat gta gac ggc gag aat tcg aca 2064 Leu Val Gly Tyr Ile His Val Gln Tyr Val Asp Gly Glu Asn Ser Thr 675 680 685 att atc aag aaa aga gtt gaa aaa ata ttc gaa aat gtg tcg att aaa 2112 Ile Ile Lys Lys Arg Val Glu Lys Ile Phe Glu Asn Val Ser Ile Lys 690 695 700 gcg tgg gta caa gtt gag cct caa aat tcc act tgt tgg tgc cgg gct 2160 Ala Trp Val Gln Val Glu Pro Gln Asn Ser Thr Cys Trp Cys Arg Ala 705 710 715 720 act tct atg aac aca att tca gct aac ccg aat tct tta ccg cta cag 2208 Thr Ser Met Asn Thr Ile Ser Ala Asn Pro Asn Ser Leu Pro Leu Gln 725 730 735 cct ata gca aat tga 2223 Pro Ile Ala Asn 740 <210> 230 <211> 740 <212> PRT <213> Saccharomyces cerevisiae <400> 230 Met Asp Arg Gly Arg Trp Cys Phe Leu Val Ser Val Ser Ser Arg Ile 1 5 10 15 Met Asn Leu Gln Glu Leu Leu Ala Lys Val Pro Leu Leu Leu Ser Tyr 20 25 30 Pro Thr Ile Ile Leu Ser Ser Asn Leu Ile Val Pro Ser His Asn Asp 35 40 45 Page 334 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Ile Ser Arg Ala Ala Ser Thr Ser Ala Ala Glu Tyr Ala Asp Glu 50 55 60 Lys Leu Ile Phe Phe Ser Thr Asp His Ala Ile Arg Leu Ile Phe Leu 65 70 75 80 Pro Thr Phe Val Ala Ser Ser Phe Asn Leu Phe Ala His Tyr Phe Asn 85 90 95 Phe Ile Asn Tyr Ser Ser Arg Arg Lys Tyr Tyr Val Leu Phe Thr Ala 100 105 110 Ile Tyr Phe Leu Ser Ile Leu Thr Ala Ile Phe His Pro Ile Gln Ser 115 120 125 Thr Cys Ile Thr Leu Leu Ile Ile Lys Leu Leu Thr Thr Ala Asp Glu 130 135 140 Ser Ser Pro Lys Ile Ala Leu Asn Phe Lys Thr Ile Leu Lys Thr Phe 145 150 155 160 Val Pro Phe Ile Thr Leu Thr Leu Val Ile Leu Arg Trp Asp Pro Ser 165 170 175 Phe Asp Ala Ser Ser Gly Asp Val Asn Lys Ile Ser Thr Ser Leu Ala 180 185 190 Ala Tyr Ala Leu Leu Ile Leu Thr Leu Arg Tyr Ala Ser Pro Leu Ile 195 200 205 Leu Ser Thr Leu Ser Ser Ser Ile Gly Val Val Ser Lys Asp Thr Ser 210 215 220 Val Ala Gln His Ser Ile Ser Arg Asn Lys Arg Phe Pro Leu Ile Leu 225 230 235 240 Val Leu Pro Ile Phe Ser Phe Val Leu Leu Tyr Leu Met Thr Ile Val 245 250 255 Asn Lys Thr Tyr Asn Ile Gln Leu Leu Met Val Phe Val Phe Phe Gly 260 265 270 Cys Leu Ser Ile Phe Phe Leu Ser Leu Lys Asp Leu Phe Thr Glu Asp 275 280 285 Gly Asn Gln Lys Lys Gly Gly Gln Glu Asp Glu Tyr Cys Arg Met Phe 290 295 300 Asp Ile Lys Tyr Met Ile Ser Tyr Leu Trp Leu Thr Arg Phe Thr Ile 305 310 315 320 Page 335 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Leu Thr Gly Ile Met Ala Ile Val Val His Phe Leu Ser Phe Asn 325 330 335 Glu Ile Thr Ser Ser Ile Lys Thr Asp Leu Leu Ser Leu Leu Phe Val 340 345 350 Val Val Ala Glu Tyr Val Ser Ser Phe Ser Asn Lys Gln Pro Asp Ser 355 360 365 His Ser His Asn His Ala His His His Ser His Leu Thr Asp Ser Leu 370 375 380 Pro Leu Glu Asn Glu Ser Met Phe Lys Gln Met Ala Leu Asn Lys Asp 385 390 395 400 Thr Arg Ser Ile Phe Ser Phe Leu Leu Leu Asn Thr Ala Phe Met Phe 405 410 415 Val Gln Leu Leu Tyr Ser Phe Arg Ser Lys Ser Leu Gly Leu Leu Ser 420 425 430 Asp Ser Leu His Met Ala Leu Asp Cys Thr Ser Leu Leu Leu Gly Leu 435 440 445 Ile Ala Gly Val Leu Thr Lys Lys Pro Ala Ser Asp Lys Phe Pro Phe 450 455 460 Gly Leu Asn Tyr Leu Gly Thr Leu Ala Gly Phe Thr Asn Gly Val Leu 465 470 475 480 Leu Leu Gly Ile Val Cys Gly Ile Phe Val Glu Ala Ile Glu Arg Ile 485 490 495 Phe Asn Pro Ile His Leu His Ala Thr Asn Glu Leu Leu Val Val Ala 500 505 510 Thr Leu Gly Leu Leu Val Asn Leu Val Gly Leu Phe Ala Phe Asp His 515 520 525 Gly Ala His Asp His Gly Gly Thr Asp Asn Glu Asn Met Lys Gly Ile 530 535 540 Phe Leu His Ile Leu Ala Asp Thr Leu Gly Ser Val Gly Val Val Ile 545 550 555 560 Ser Thr Leu Leu Ile Lys Leu Thr His Trp Pro Ile Phe Asp Pro Ile 565 570 575 Ala Ser Leu Leu Ile Gly Ser Leu Ile Leu Leu Ser Ala Leu Pro Leu 580 585 590 Page 336 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Lys Ser Thr Ser Ala Asn Ile Leu Leu Arg Leu Asp Asp Lys Lys 595 600 605 His Asn Leu Val Lys Ser Ala Leu Asn Gln Ile Ser Thr Thr Pro Gly 610 615 620 Ile Thr Gly Tyr Thr Thr Pro Arg Phe Trp Pro Thr Glu Ser Gly Ser 625 630 635 640 Ser Gly His Ser His Ala His Thr His Ser His Ala Glu Asn His Ser 645 650 655 His Glu His His His Asp Gln Lys Asn Gly Ser Gln Glu His Pro Ser 660 665 670 Leu Val Gly Tyr Ile His Val Gln Tyr Val Asp Gly Glu Asn Ser Thr 675 680 685 Ile Ile Lys Lys Arg Val Glu Lys Ile Phe Glu Asn Val Ser Ile Lys 690 695 700 Ala Trp Val Gln Val Glu Pro Gln Asn Ser Thr Cys Trp Cys Arg Ala 705 710 715 720 Thr Ser Met Asn Thr Ile Ser Ala Asn Pro Asn Ser Leu Pro Leu Gln 725 730 735 Pro Ile Ala Asn 740 <210> 231 <211> 591 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(591) <400> 231 atg aaa cag ata gtc aaa aga agc cat gcc atc aga ata gtt gca gca 48 Met Lys Gln Ile Val Lys Arg Ser His Ala Ile Arg Ile Val Ala Ala 1 5 10 15 tta gga atc ata ggc ctg tgg atg ttt ttc tcg tct aat gaa cta tcc 96 Leu Gly Ile Ile Gly Leu Trp Met Phe Phe Ser Ser Asn Glu Leu Ser 20 25 30 atc gct acg ccg ggc cta atc aag gcg aag tct ggt ata gat gaa gtg 144 Ile Ala Thr Pro Gly Leu Ile Lys Ala Lys Ser Gly Ile Asp Glu Val 35 40 45 caa ggg gcg gct gct gag aag aac gac gct cgg ttg aaa gag atc gag 192 Gln Gly Ala Ala Ala Glu Lys Asn Asp Ala Arg Leu Lys Glu Ile Glu 50 55 60 Page 337 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag caa acc att atg cca ttg atg ggc gat gac aag gtg aag aag gaa 240 Lys Gln Thr Ile Met Pro Leu Met Gly Asp Asp Lys Val Lys Lys Glu 65 70 75 80 gtg ggc agg gcg tcg tgg aag tac ttc cat acc ctg ctg gcc cgt ttt 288 Val Gly Arg Ala Ser Trp Lys Tyr Phe His Thr Leu Leu Ala Arg Phe 85 90 95 ccg gac gag cct act cct gaa gaa aga gag aaa ctg cac acg ttt att 336 Pro Asp Glu Pro Thr Pro Glu Glu Arg Glu Lys Leu His Thr Phe Ile 100 105 110 ggg ttg tat gca gaa ctc tat cca tgc ggg gaa tgt tca tat cac ttt 384 Gly Leu Tyr Ala Glu Leu Tyr Pro Cys Gly Glu Cys Ser Tyr His Phe 115 120 125 gta aag ttg att gag aag tat ccc gta cag aca tct agc agg acg gct 432 Val Lys Leu Ile Glu Lys Tyr Pro Val Gln Thr Ser Ser Arg Thr Ala 130 135 140 gcc gca atg tgg gga tgc cac att cac aac aag gtg aac gaa tac cta 480 Ala Ala Met Trp Gly Cys His Ile His Asn Lys Val Asn Glu Tyr Leu 145 150 155 160 aag aaa gac ata tat gac tgt gct acc atc ctg gag gac tac gat tgt 528 Lys Lys Asp Ile Tyr Asp Cys Ala Thr Ile Leu Glu Asp Tyr Asp Cys 165 170 175 gga tgt agt gac agc gac ggt aaa cgc gtg tct ctc gag aag gag gct 576 Gly Cys Ser Asp Ser Asp Gly Lys Arg Val Ser Leu Glu Lys Glu Ala 180 185 190 aaa cag cac ggt tga 591 Lys Gln His Gly 195 <210> 232 <211> 196 <212> PRT <213> Saccharomyces cerevisiae <400> 232 Met Lys Gln Ile Val Lys Arg Ser His Ala Ile Arg Ile Val Ala Ala 1 5 10 15 Leu Gly Ile Ile Gly Leu Trp Met Phe Phe Ser Ser Asn Glu Leu Ser 20 25 30 Ile Ala Thr Pro Gly Leu Ile Lys Ala Lys Ser Gly Ile Asp Glu Val 35 40 45 Gln Gly Ala Ala Ala Glu Lys Asn Asp Ala Arg Leu Lys Glu Ile Glu 50 55 60 Lys Gln Thr Ile Met Pro Leu Met Gly Asp Asp Lys Val Lys Lys Glu 65 70 75 80 Val Gly Arg Ala Ser Trp Lys Tyr Phe His Thr Leu Leu Ala Arg Phe 85 90 95 Page 338 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Asp Glu Pro Thr Pro Glu Glu Arg Glu Lys Leu His Thr Phe Ile 100 105 110 Gly Leu Tyr Ala Glu Leu Tyr Pro Cys Gly Glu Cys Ser Tyr His Phe 115 120 125 Val Lys Leu Ile Glu Lys Tyr Pro Val Gln Thr Ser Ser Arg Thr Ala 130 135 140 Ala Ala Met Trp Gly Cys His Ile His Asn Lys Val Asn Glu Tyr Leu 145 150 155 160 Lys Lys Asp Ile Tyr Asp Cys Ala Thr Ile Leu Glu Asp Tyr Asp Cys 165 170 175 Gly Cys Ser Asp Ser Asp Gly Lys Arg Val Ser Leu Glu Lys Glu Ala 180 185 190 Lys Gln His Gly 195 <210> 233 <211> 1986 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1986) <400> 233 atg ggc aca ctg ttt cga aga aat gtc cag aac caa aag agt gat tct 48 Met Gly Thr Leu Phe Arg Arg Asn Val Gln Asn Gln Lys Ser Asp Ser 1 5 10 15 gat gaa aac aat aaa ggg ggt tct gtt cat aac aag cga gag agc aga 96 Asp Glu Asn Asn Lys Gly Gly Ser Val His Asn Lys Arg Glu Ser Arg 20 25 30 aac cac att cat cat caa cag gga tta ggc cat aag aga aga agg ggt 144 Asn His Ile His His Gln Gln Gly Leu Gly His Lys Arg Arg Arg Gly 35 40 45 att agt ggc agt gca aaa aga aat gag cgt ggc aaa gat ttc gac agg 192 Ile Ser Gly Ser Ala Lys Arg Asn Glu Arg Gly Lys Asp Phe Asp Arg 50 55 60 aaa aga gac ggg aac ggt aga aaa cgt tgg aga gat tcc aga aga ctg 240 Lys Arg Asp Gly Asn Gly Arg Lys Arg Trp Arg Asp Ser Arg Arg Leu 65 70 75 80 att ttc att ctt ggt gca ttc tta ggt gta ctt ttg ccg ttt agc ttt 288 Ile Phe Ile Leu Gly Ala Phe Leu Gly Val Leu Leu Pro Phe Ser Phe 85 90 95 ggc gct tat cat gtt cat aat agc gat agc gac ttg ttt gac aac ttt 336 Gly Ala Tyr His Val His Asn Ser Asp Ser Asp Leu Phe Asp Asn Phe 100 105 110 gta aat ttt gat tca ctt aaa gtg tat ttg gat gat tgg aaa gat gtt 384 Page 339 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Asn Phe Asp Ser Leu Lys Val Tyr Leu Asp Asp Trp Lys Asp Val 115 120 125 ctc cca caa ggt ata agt tcg ttt att gat gat att cag gct ggt aac 432 Leu Pro Gln Gly Ile Ser Ser Phe Ile Asp Asp Ile Gln Ala Gly Asn 130 135 140 tac tcc aca tct tct tta gat gat ctc agt gaa aat ttt gcc gtt ggt 480 Tyr Ser Thr Ser Ser Leu Asp Asp Leu Ser Glu Asn Phe Ala Val Gly 145 150 155 160 aaa caa ctc tta cgt gat tat aat atc gag gcc aaa cat cct gtt gta 528 Lys Gln Leu Leu Arg Asp Tyr Asn Ile Glu Ala Lys His Pro Val Val 165 170 175 atg gtt cct ggt gtc att tct acg gga att gaa agc tgg gga gtt att 576 Met Val Pro Gly Val Ile Ser Thr Gly Ile Glu Ser Trp Gly Val Ile 180 185 190 gga gac gat gag tgc gat agt tct gcg cat ttt cgt aaa cgg ctg tgg 624 Gly Asp Asp Glu Cys Asp Ser Ser Ala His Phe Arg Lys Arg Leu Trp 195 200 205 gga agt ttt tac atg ctg aga aca atg gtt atg gat aaa gtt tgt tgg 672 Gly Ser Phe Tyr Met Leu Arg Thr Met Val Met Asp Lys Val Cys Trp 210 215 220 ttg aaa cat gta atg tta gat cct gaa aca ggt ctg gac cca ccg aac 720 Leu Lys His Val Met Leu Asp Pro Glu Thr Gly Leu Asp Pro Pro Asn 225 230 235 240 ttt acg cta cgt gca gca cag ggc ttc gaa tca act gat tat ttc atc 768 Phe Thr Leu Arg Ala Ala Gln Gly Phe Glu Ser Thr Asp Tyr Phe Ile 245 250 255 gca ggg tat tgg att tgg aac aaa gtt ttc caa aat ctg gga gta att 816 Ala Gly Tyr Trp Ile Trp Asn Lys Val Phe Gln Asn Leu Gly Val Ile 260 265 270 ggc tat gaa ccc aat aaa atg acg agt gct gcg tat gat tgg agg ctt 864 Gly Tyr Glu Pro Asn Lys Met Thr Ser Ala Ala Tyr Asp Trp Arg Leu 275 280 285 gca tat tta gat cta gaa aga cgc gat agg tac ttt acg aag cta aag 912 Ala Tyr Leu Asp Leu Glu Arg Arg Asp Arg Tyr Phe Thr Lys Leu Lys 290 295 300 gaa caa atc gaa ctg ttt cat caa ttg agt ggt gaa aaa gtt tgt tta 960 Glu Gln Ile Glu Leu Phe His Gln Leu Ser Gly Glu Lys Val Cys Leu 305 310 315 320 att gga cat tct atg ggt tct cag att atc ttt tac ttt atg aaa tgg 1008 Ile Gly His Ser Met Gly Ser Gln Ile Ile Phe Tyr Phe Met Lys Trp 325 330 335 gtc gag gct gaa ggc cct ctt tac ggt aat ggt ggt cgt ggc tgg gtt 1056 Val Glu Ala Glu Gly Pro Leu Tyr Gly Asn Gly Gly Arg Gly Trp Val 340 345 350 aac gaa cac ata gat tca ttc att aat gca gca ggg acg ctt ctg ggc 1104 Asn Glu His Ile Asp Ser Phe Ile Asn Ala Ala Gly Thr Leu Leu Gly 355 360 365 gct cca aag gca gtt cca gct cta att agt ggt gaa atg aaa gat acc 1152 Ala Pro Lys Ala Val Pro Ala Leu Ile Ser Gly Glu Met Lys Asp Thr 370 375 380 att caa tta aat acg tta gcc atg tat ggt ttg gaa aag ttc ttc tca 1200 Page 340 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Gln Leu Asn Thr Leu Ala Met Tyr Gly Leu Glu Lys Phe Phe Ser 385 390 395 400 aga att gag aga gta aaa atg tta caa acg tgg ggt ggt ata cca tca 1248 Arg Ile Glu Arg Val Lys Met Leu Gln Thr Trp Gly Gly Ile Pro Ser 405 410 415 atg cta cca aag gga gaa gag gtc att tgg ggg gat atg aag tca tct 1296 Met Leu Pro Lys Gly Glu Glu Val Ile Trp Gly Asp Met Lys Ser Ser 420 425 430 tca gag gat gca ttg aat aac aac act gac aca tac ggc aat ttc att 1344 Ser Glu Asp Ala Leu Asn Asn Asn Thr Asp Thr Tyr Gly Asn Phe Ile 435 440 445 cga ttt gaa agg aat acg agc gat gct ttc aac aaa aat ttg aca atg 1392 Arg Phe Glu Arg Asn Thr Ser Asp Ala Phe Asn Lys Asn Leu Thr Met 450 455 460 aaa gac gcc att aac atg aca tta tcg ata tca cct gaa tgg ctc caa 1440 Lys Asp Ala Ile Asn Met Thr Leu Ser Ile Ser Pro Glu Trp Leu Gln 465 470 475 480 aga aga gta cat gag cag tac tcg ttc ggc tat tcc aag aat gaa gaa 1488 Arg Arg Val His Glu Gln Tyr Ser Phe Gly Tyr Ser Lys Asn Glu Glu 485 490 495 gag tta aga aaa aat gag cta cac cac aag cac tgg tcg aat cca atg 1536 Glu Leu Arg Lys Asn Glu Leu His His Lys His Trp Ser Asn Pro Met 500 505 510 gaa gta cca ctt cca gaa gct ccc cac atg aaa atc tat tgt ata tac 1584 Glu Val Pro Leu Pro Glu Ala Pro His Met Lys Ile Tyr Cys Ile Tyr 515 520 525 ggg gtg aac aac cca act gaa agg gca tat gta tat aag gaa gag gat 1632 Gly Val Asn Asn Pro Thr Glu Arg Ala Tyr Val Tyr Lys Glu Glu Asp 530 535 540 gac tcc tct gct ctg aat ttg acc atc gac tac gaa agc aag caa cct 1680 Asp Ser Ser Ala Leu Asn Leu Thr Ile Asp Tyr Glu Ser Lys Gln Pro 545 550 555 560 gta ttc ctc acc gag ggg gac gga acc gtt ccg ctc gtg gcg cat tca 1728 Val Phe Leu Thr Glu Gly Asp Gly Thr Val Pro Leu Val Ala His Ser 565 570 575 atg tgt cac aaa tgg gcc cag ggt gct tca ccg tac aac cct gcc gga 1776 Met Cys His Lys Trp Ala Gln Gly Ala Ser Pro Tyr Asn Pro Ala Gly 580 585 590 att aac gtt act att gtg gaa atg aaa cac cag cca gat cga ttt gat 1824 Ile Asn Val Thr Ile Val Glu Met Lys His Gln Pro Asp Arg Phe Asp 595 600 605 ata cgt ggt gga gca aaa agc gcc gaa cac gta gac atc ctc ggc agc 1872 Ile Arg Gly Gly Ala Lys Ser Ala Glu His Val Asp Ile Leu Gly Ser 610 615 620 gcg gag ttg aac gat tac atc ttg aaa att gca agc ggt aat ggc gat 1920 Ala Glu Leu Asn Asp Tyr Ile Leu Lys Ile Ala Ser Gly Asn Gly Asp 625 630 635 640 ctc gtc gag cca cgc caa ttg tct aat ttg agc cag tgg gtt tct cag 1968 Leu Val Glu Pro Arg Gln Leu Ser Asn Leu Ser Gln Trp Val Ser Gln 645 650 655 atg ccc ttc cca atg taa 1986 Page 341 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Pro Phe Pro Met 660 <210> 234 <211> 661 <212> PRT <213> Saccharomyces cerevisiae <400> 234 Met Gly Thr Leu Phe Arg Arg Asn Val Gln Asn Gln Lys Ser Asp Ser 1 5 10 15 Asp Glu Asn Asn Lys Gly Gly Ser Val His Asn Lys Arg Glu Ser Arg 20 25 30 Asn His Ile His His Gln Gln Gly Leu Gly His Lys Arg Arg Arg Gly 35 40 45 Ile Ser Gly Ser Ala Lys Arg Asn Glu Arg Gly Lys Asp Phe Asp Arg 50 55 60 Lys Arg Asp Gly Asn Gly Arg Lys Arg Trp Arg Asp Ser Arg Arg Leu 65 70 75 80 Ile Phe Ile Leu Gly Ala Phe Leu Gly Val Leu Leu Pro Phe Ser Phe 85 90 95 Gly Ala Tyr His Val His Asn Ser Asp Ser Asp Leu Phe Asp Asn Phe 100 105 110 Val Asn Phe Asp Ser Leu Lys Val Tyr Leu Asp Asp Trp Lys Asp Val 115 120 125 Leu Pro Gln Gly Ile Ser Ser Phe Ile Asp Asp Ile Gln Ala Gly Asn 130 135 140 Tyr Ser Thr Ser Ser Leu Asp Asp Leu Ser Glu Asn Phe Ala Val Gly 145 150 155 160 Lys Gln Leu Leu Arg Asp Tyr Asn Ile Glu Ala Lys His Pro Val Val 165 170 175 Met Val Pro Gly Val Ile Ser Thr Gly Ile Glu Ser Trp Gly Val Ile 180 185 190 Gly Asp Asp Glu Cys Asp Ser Ser Ala His Phe Arg Lys Arg Leu Trp 195 200 205 Gly Ser Phe Tyr Met Leu Arg Thr Met Val Met Asp Lys Val Cys Trp 210 215 220 Leu Lys His Val Met Leu Asp Pro Glu Thr Gly Leu Asp Pro Pro Asn Page 342 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 225 230 235 240 Phe Thr Leu Arg Ala Ala Gln Gly Phe Glu Ser Thr Asp Tyr Phe Ile 245 250 255 Ala Gly Tyr Trp Ile Trp Asn Lys Val Phe Gln Asn Leu Gly Val Ile 260 265 270 Gly Tyr Glu Pro Asn Lys Met Thr Ser Ala Ala Tyr Asp Trp Arg Leu 275 280 285 Ala Tyr Leu Asp Leu Glu Arg Arg Asp Arg Tyr Phe Thr Lys Leu Lys 290 295 300 Glu Gln Ile Glu Leu Phe His Gln Leu Ser Gly Glu Lys Val Cys Leu 305 310 315 320 Ile Gly His Ser Met Gly Ser Gln Ile Ile Phe Tyr Phe Met Lys Trp 325 330 335 Val Glu Ala Glu Gly Pro Leu Tyr Gly Asn Gly Gly Arg Gly Trp Val 340 345 350 Asn Glu His Ile Asp Ser Phe Ile Asn Ala Ala Gly Thr Leu Leu Gly 355 360 365 Ala Pro Lys Ala Val Pro Ala Leu Ile Ser Gly Glu Met Lys Asp Thr 370 375 380 Ile Gln Leu Asn Thr Leu Ala Met Tyr Gly Leu Glu Lys Phe Phe Ser 385 390 395 400 Arg Ile Glu Arg Val Lys Met Leu Gln Thr Trp Gly Gly Ile Pro Ser 405 410 415 Met Leu Pro Lys Gly Glu Glu Val Ile Trp Gly Asp Met Lys Ser Ser 420 425 430 Ser Glu Asp Ala Leu Asn Asn Asn Thr Asp Thr Tyr Gly Asn Phe Ile 435 440 445 Arg Phe Glu Arg Asn Thr Ser Asp Ala Phe Asn Lys Asn Leu Thr Met 450 455 460 Lys Asp Ala Ile Asn Met Thr Leu Ser Ile Ser Pro Glu Trp Leu Gln 465 470 475 480 Arg Arg Val His Glu Gln Tyr Ser Phe Gly Tyr Ser Lys Asn Glu Glu 485 490 495 Glu Leu Arg Lys Asn Glu Leu His His Lys His Trp Ser Asn Pro Met Page 343 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 500 505 510 Glu Val Pro Leu Pro Glu Ala Pro His Met Lys Ile Tyr Cys Ile Tyr 515 520 525 Gly Val Asn Asn Pro Thr Glu Arg Ala Tyr Val Tyr Lys Glu Glu Asp 530 535 540 Asp Ser Ser Ala Leu Asn Leu Thr Ile Asp Tyr Glu Ser Lys Gln Pro 545 550 555 560 Val Phe Leu Thr Glu Gly Asp Gly Thr Val Pro Leu Val Ala His Ser 565 570 575 Met Cys His Lys Trp Ala Gln Gly Ala Ser Pro Tyr Asn Pro Ala Gly 580 585 590 Ile Asn Val Thr Ile Val Glu Met Lys His Gln Pro Asp Arg Phe Asp 595 600 605 Ile Arg Gly Gly Ala Lys Ser Ala Glu His Val Asp Ile Leu Gly Ser 610 615 620 Ala Glu Leu Asn Asp Tyr Ile Leu Lys Ile Ala Ser Gly Asn Gly Asp 625 630 635 640 Leu Val Glu Pro Arg Gln Leu Ser Asn Leu Ser Gln Trp Val Ser Gln 645 650 655 Met Pro Phe Pro Met 660 <210> 235 <211> 1164 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1164) <400> 235 atg gaa cag aac agg ttc aag aaa gaa acg aaa act tgt agc gct agc 48 Met Glu Gln Asn Arg Phe Lys Lys Glu Thr Lys Thr Cys Ser Ala Ser 1 5 10 15 tgg ccg cgc gca ccg cag tcg acg ctg tgt gcg aca gat cgc ctc gag 96 Trp Pro Arg Ala Pro Gln Ser Thr Leu Cys Ala Thr Asp Arg Leu Glu 20 25 30 ctc aca tac gat gtg tac act agc gca gag cgg caa cgc cgc tct cgc 144 Leu Thr Tyr Asp Val Tyr Thr Ser Ala Glu Arg Gln Arg Arg Ser Arg 35 40 45 act gcc act agg ctt aac ctt gtg ttt ttg cac ggc agc ggc atg agt 192 Thr Ala Thr Arg Leu Asn Leu Val Phe Leu His Gly Ser Gly Met Ser Page 344 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 50 55 60 aag gtg gta tgg gag tac tat ttg ccg cgt ctg gta gcc gcc gat gcg 240 Lys Val Val Trp Glu Tyr Tyr Leu Pro Arg Leu Val Ala Ala Asp Ala 65 70 75 80 gag ggc aat tat gcc atc gac aag gtt ttg ttg atc gac cag gtt aac 288 Glu Gly Asn Tyr Ala Ile Asp Lys Val Leu Leu Ile Asp Gln Val Asn 85 90 95 cac ggt gat tct gcg gta cgc aac cgc ggc aga ctc ggc acc aat ttc 336 His Gly Asp Ser Ala Val Arg Asn Arg Gly Arg Leu Gly Thr Asn Phe 100 105 110 aac tgg atc gac ggg gcc cgc gac gtg ctc aag att gcc aca tgc gag 384 Asn Trp Ile Asp Gly Ala Arg Asp Val Leu Lys Ile Ala Thr Cys Glu 115 120 125 ttg ggc agt att gac agc cac ccg gca cta aac gta gtc atc ggc cac 432 Leu Gly Ser Ile Asp Ser His Pro Ala Leu Asn Val Val Ile Gly His 130 135 140 tcg atg ggc ggg ttc cag gct ctt gcg tgt gac gtc ctg cag ccc aat 480 Ser Met Gly Gly Phe Gln Ala Leu Ala Cys Asp Val Leu Gln Pro Asn 145 150 155 160 ctg ttt cat ttg ctc atc ttg atc gag cct gta gta atc aca cgg aaa 528 Leu Phe His Leu Leu Ile Leu Ile Glu Pro Val Val Ile Thr Arg Lys 165 170 175 gcc atc ggc gcc ggg agg cca ggg ctt ccg ccc gat tct ccg cag atc 576 Ala Ile Gly Ala Gly Arg Pro Gly Leu Pro Pro Asp Ser Pro Gln Ile 180 185 190 cca gaa aat ctt tat aac tcc cta cgt tta aag acg tgc gac cat ttc 624 Pro Glu Asn Leu Tyr Asn Ser Leu Arg Leu Lys Thr Cys Asp His Phe 195 200 205 gct aac gag tcc gaa tat gta aaa tat atg agg aac ggt tcc ttt ttt 672 Ala Asn Glu Ser Glu Tyr Val Lys Tyr Met Arg Asn Gly Ser Phe Phe 210 215 220 acc aat gcg cac agc caa atc ctg caa aac atc atc gat ttt gag agg 720 Thr Asn Ala His Ser Gln Ile Leu Gln Asn Ile Ile Asp Phe Glu Arg 225 230 235 240 aca aaa gcc tct gga gac gat gaa gat ggt gga ccc gtt cgc acg aag 768 Thr Lys Ala Ser Gly Asp Asp Glu Asp Gly Gly Pro Val Arg Thr Lys 245 250 255 atg gag cag gct caa aat ctc ctc tgc tac atg aac atg cag act ttt 816 Met Glu Gln Ala Gln Asn Leu Leu Cys Tyr Met Asn Met Gln Thr Phe 260 265 270 gcg cct ttc ctg atc agc aat gtg aag ttt gtg agg aag cgg act atc 864 Ala Pro Phe Leu Ile Ser Asn Val Lys Phe Val Arg Lys Arg Thr Ile 275 280 285 cac att gtg ggc gcg cgc tcc aac tgg tgt cct ccg caa aat cag ctg 912 His Ile Val Gly Ala Arg Ser Asn Trp Cys Pro Pro Gln Asn Gln Leu 290 295 300 ttt ttg cag aaa act cta cag aac tac cat ctc gat gtc att ccc ggc 960 Phe Leu Gln Lys Thr Leu Gln Asn Tyr His Leu Asp Val Ile Pro Gly 305 310 315 320 ggc tcc cac ttg gtc aac gtt gag gct ccg gac ctg gtg atc gag agg 1008 Gly Ser His Leu Val Asn Val Glu Ala Pro Asp Leu Val Ile Glu Arg Page 345 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 325 330 335 att aat cac cac atc cac gag ttt gtc ctt acc tcc ccg ctg cag tcc 1056 Ile Asn His His Ile His Glu Phe Val Leu Thr Ser Pro Leu Gln Ser 340 345 350 tca cac att ccg caa ttg acc ctt gaa gaa aga gcg gtg atg ttt gac 1104 Ser His Ile Pro Gln Leu Thr Leu Glu Glu Arg Ala Val Met Phe Asp 355 360 365 cgg gct ttc gac tcg ttc aag aat gaa gct ttg gtt aaa acg act aaa 1152 Arg Ala Phe Asp Ser Phe Lys Asn Glu Ala Leu Val Lys Thr Thr Lys 370 375 380 caa aaa ctg taa 1164 Gln Lys Leu 385 <210> 236 <211> 387 <212> PRT <213> Saccharomyces cerevisiae <400> 236 Met Glu Gln Asn Arg Phe Lys Lys Glu Thr Lys Thr Cys Ser Ala Ser 1 5 10 15 Trp Pro Arg Ala Pro Gln Ser Thr Leu Cys Ala Thr Asp Arg Leu Glu 20 25 30 Leu Thr Tyr Asp Val Tyr Thr Ser Ala Glu Arg Gln Arg Arg Ser Arg 35 40 45 Thr Ala Thr Arg Leu Asn Leu Val Phe Leu His Gly Ser Gly Met Ser 50 55 60 Lys Val Val Trp Glu Tyr Tyr Leu Pro Arg Leu Val Ala Ala Asp Ala 65 70 75 80 Glu Gly Asn Tyr Ala Ile Asp Lys Val Leu Leu Ile Asp Gln Val Asn 85 90 95 His Gly Asp Ser Ala Val Arg Asn Arg Gly Arg Leu Gly Thr Asn Phe 100 105 110 Asn Trp Ile Asp Gly Ala Arg Asp Val Leu Lys Ile Ala Thr Cys Glu 115 120 125 Leu Gly Ser Ile Asp Ser His Pro Ala Leu Asn Val Val Ile Gly His 130 135 140 Ser Met Gly Gly Phe Gln Ala Leu Ala Cys Asp Val Leu Gln Pro Asn 145 150 155 160 Leu Phe His Leu Leu Ile Leu Ile Glu Pro Val Val Ile Thr Arg Lys 165 170 175 Page 346 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Ile Gly Ala Gly Arg Pro Gly Leu Pro Pro Asp Ser Pro Gln Ile 180 185 190 Pro Glu Asn Leu Tyr Asn Ser Leu Arg Leu Lys Thr Cys Asp His Phe 195 200 205 Ala Asn Glu Ser Glu Tyr Val Lys Tyr Met Arg Asn Gly Ser Phe Phe 210 215 220 Thr Asn Ala His Ser Gln Ile Leu Gln Asn Ile Ile Asp Phe Glu Arg 225 230 235 240 Thr Lys Ala Ser Gly Asp Asp Glu Asp Gly Gly Pro Val Arg Thr Lys 245 250 255 Met Glu Gln Ala Gln Asn Leu Leu Cys Tyr Met Asn Met Gln Thr Phe 260 265 270 Ala Pro Phe Leu Ile Ser Asn Val Lys Phe Val Arg Lys Arg Thr Ile 275 280 285 His Ile Val Gly Ala Arg Ser Asn Trp Cys Pro Pro Gln Asn Gln Leu 290 295 300 Phe Leu Gln Lys Thr Leu Gln Asn Tyr His Leu Asp Val Ile Pro Gly 305 310 315 320 Gly Ser His Leu Val Asn Val Glu Ala Pro Asp Leu Val Ile Glu Arg 325 330 335 Ile Asn His His Ile His Glu Phe Val Leu Thr Ser Pro Leu Gln Ser 340 345 350 Ser His Ile Pro Gln Leu Thr Leu Glu Glu Arg Ala Val Met Phe Asp 355 360 365 Arg Ala Phe Asp Ser Phe Lys Asn Glu Ala Leu Val Lys Thr Thr Lys 370 375 380 Gln Lys Leu 385 <210> 237 <211> 1929 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1929) Page 347 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 237 atg tca tct cag ttt ttc ctg aaa acc tct cag gat ata gag ctc ttc 48 Met Ser Ser Gln Phe Phe Leu Lys Thr Ser Gln Asp Ile Glu Leu Phe 1 5 10 15 caa agc tac cca act ttt gag caa tcc aac aca aac tcc aag gat ttc 96 Gln Ser Tyr Pro Thr Phe Glu Gln Ser Asn Thr Asn Ser Lys Asp Phe 20 25 30 cct gtc att tcc tcg gtt tta tcg cca tgt ggc aga ttt ttg gct tta 144 Pro Val Ile Ser Ser Val Leu Ser Pro Cys Gly Arg Phe Leu Ala Leu 35 40 45 tct acg aag gag aac gtc aaa gtt ttt aca ggt cca tgt ttg gat aac 192 Ser Thr Lys Glu Asn Val Lys Val Phe Thr Gly Pro Cys Leu Asp Asn 50 55 60 gtt cta tta aca atg aag ttg tcc gac gtc tat gac cta cac ttc tct 240 Val Leu Leu Thr Met Lys Leu Ser Asp Val Tyr Asp Leu His Phe Ser 65 70 75 80 cca gca ggt aac tac tta agc act tgg gag aga gcg tct ata caa gac 288 Pro Ala Gly Asn Tyr Leu Ser Thr Trp Glu Arg Ala Ser Ile Gln Asp 85 90 95 cca aat cac aag aac gtt aaa gtt tgg tat ttg aat aaa cca ttt aag 336 Pro Asn His Lys Asn Val Lys Val Trp Tyr Leu Asn Lys Pro Phe Lys 100 105 110 aaa gat tgc gtt tcg gag gat ata gtc cct gct tac gaa tat caa gcc 384 Lys Asp Cys Val Ser Glu Asp Ile Val Pro Ala Tyr Glu Tyr Gln Ala 115 120 125 aaa tcc caa agc ggt tgg ttt tta caa ttc tcc aaa tta gac aat tat 432 Lys Ser Gln Ser Gly Trp Phe Leu Gln Phe Ser Lys Leu Asp Asn Tyr 130 135 140 ggg cta aga ctt ttt aaa cac gac ttg aag att gtt aaa tta agc tcc 480 Gly Leu Arg Leu Phe Lys His Asp Leu Lys Ile Val Lys Leu Ser Ser 145 150 155 160 gct aat gcc gac aat ttc gac ttc caa tct ccg ttt gct gtc ttg tct 528 Ala Asn Ala Asp Asn Phe Asp Phe Gln Ser Pro Phe Ala Val Leu Ser 165 170 175 gat gat gaa acg tcc caa cat ttc acc acc tac cta atc tct cca gct 576 Asp Asp Glu Thr Ser Gln His Phe Thr Thr Tyr Leu Ile Ser Pro Ala 180 185 190 gaa cat cca aca att tgt act ttc aca cca gaa aag ggt ggt aaa ccg 624 Glu His Pro Thr Ile Cys Thr Phe Thr Pro Glu Lys Gly Gly Lys Pro 195 200 205 gct caa tta atc ata tgg gcc ctc tct gaa ggt aaa atc acc aag aaa 672 Ala Gln Leu Ile Ile Trp Ala Leu Ser Glu Gly Lys Ile Thr Lys Lys 210 215 220 att gcc tcc aaa act ttc ttt aaa gct gat tcc tgc caa ttg aaa tgg 720 Ile Ala Ser Lys Thr Phe Phe Lys Ala Asp Ser Cys Gln Leu Lys Trp 225 230 235 240 aat cca tta ggt aat gct att tta tgt tta gct att act gat ttt gat 768 Asn Pro Leu Gly Asn Ala Ile Leu Cys Leu Ala Ile Thr Asp Phe Asp 245 250 255 tcc tca aac aaa tca tat tat ggt gaa aac aca cta tac tta ctg tct 816 Ser Ser Asn Lys Ser Tyr Tyr Gly Glu Asn Thr Leu Tyr Leu Leu Ser 260 265 270 Page 348 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttc caa ggt gtc aac ggg act ttg ggt ggt aac tct gta cgt gtt tct 864 Phe Gln Gly Val Asn Gly Thr Leu Gly Gly Asn Ser Val Arg Val Ser 275 280 285 tta acc act gga cct gtc cac gat ttc act tgg tcg cca act tca agg 912 Leu Thr Thr Gly Pro Val His Asp Phe Thr Trp Ser Pro Thr Ser Arg 290 295 300 caa ttc ggt gtc atc gct ggt tac atg cca gca acc att tcc ttt ttt 960 Gln Phe Gly Val Ile Ala Gly Tyr Met Pro Ala Thr Ile Ser Phe Phe 305 310 315 320 gac tta aga ggt aat gtt gtc cat tca tta cct caa caa gcc aaa aat 1008 Asp Leu Arg Gly Asn Val Val His Ser Leu Pro Gln Gln Ala Lys Asn 325 330 335 acc atg ctt ttc tct ccc tct ggt cat tac att ctt atc gcc ggg ttt 1056 Thr Met Leu Phe Ser Pro Ser Gly His Tyr Ile Leu Ile Ala Gly Phe 340 345 350 ggt aat tta cag ggc tcc gtg gaa atc cta gat cgt ctc gac aaa ttc 1104 Gly Asn Leu Gln Gly Ser Val Glu Ile Leu Asp Arg Leu Asp Lys Phe 355 360 365 aag tgt gtg agt aaa ttt gac gct acc aac act tct gtc tgc aaa tgg 1152 Lys Cys Val Ser Lys Phe Asp Ala Thr Asn Thr Ser Val Cys Lys Trp 370 375 380 tca ccg ggt gga gaa ttt atc atg aca gct acc act tca cca aga ttg 1200 Ser Pro Gly Gly Glu Phe Ile Met Thr Ala Thr Thr Ser Pro Arg Leu 385 390 395 400 aga gtg gat aac ggc gtt aaa ata tgg cat gta tca ggc tct tta gta 1248 Arg Val Asp Asn Gly Val Lys Ile Trp His Val Ser Gly Ser Leu Val 405 410 415 ttt gtt aaa gag ttc aag gag ctt ttg aag gta gac tgg agg tca cca 1296 Phe Val Lys Glu Phe Lys Glu Leu Leu Lys Val Asp Trp Arg Ser Pro 420 425 430 tgt aat tac aaa act ttg gaa aac aaa gac gaa gca ttt ttc gag aac 1344 Cys Asn Tyr Lys Thr Leu Glu Asn Lys Asp Glu Ala Phe Phe Glu Asn 435 440 445 cat atc att aat aac tgg gaa ccg cta cct gat tcg acc aca tct tca 1392 His Ile Ile Asn Asn Trp Glu Pro Leu Pro Asp Ser Thr Thr Ser Ser 450 455 460 ctt gat cct aaa ata tcc aat aaa tca gaa ttg caa ata cat tct agc 1440 Leu Asp Pro Lys Ile Ser Asn Lys Ser Glu Leu Gln Ile His Ser Ser 465 470 475 480 gtt caa gag tac ata agt caa cac cca agc aga gaa gca agc tcc aat 1488 Val Gln Glu Tyr Ile Ser Gln His Pro Ser Arg Glu Ala Ser Ser Asn 485 490 495 gga aac gga tct aag gcc aaa gct gga ggc gct tat aaa cca cct cac 1536 Gly Asn Gly Ser Lys Ala Lys Ala Gly Gly Ala Tyr Lys Pro Pro His 500 505 510 gca aga aga aca ggc ggt gga cgt att gtc ccc gga gtt cct cct ggt 1584 Ala Arg Arg Thr Gly Gly Gly Arg Ile Val Pro Gly Val Pro Pro Gly 515 520 525 gca gca aag aag acc atc cca ggg cta gtt ccg ggc atg agt gcc aac 1632 Ala Ala Lys Lys Thr Ile Pro Gly Leu Val Pro Gly Met Ser Ala Asn 530 535 540 Page 349 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag gac gcc aac acc aag aac agg aga aga aga gcc aat aaa aag tca 1680 Lys Asp Ala Asn Thr Lys Asn Arg Arg Arg Arg Ala Asn Lys Lys Ser 545 550 555 560 agt gaa acg tca cct gat tct act ccg gcc cca tct gct cct gcc tcc 1728 Ser Glu Thr Ser Pro Asp Ser Thr Pro Ala Pro Ser Ala Pro Ala Ser 565 570 575 aca aat gcc ccc aca aac aat aaa gaa act tct cca gag gag aag aaa 1776 Thr Asn Ala Pro Thr Asn Asn Lys Glu Thr Ser Pro Glu Glu Lys Lys 580 585 590 ata aga tct tta cta aag aaa tta agg gct att gaa acc ttg aag gaa 1824 Ile Arg Ser Leu Leu Lys Lys Leu Arg Ala Ile Glu Thr Leu Lys Glu 595 600 605 aga cag gcc gtc ggc gac aaa cta gaa gat acg caa gtt cta aaa att 1872 Arg Gln Ala Val Gly Asp Lys Leu Glu Asp Thr Gln Val Leu Lys Ile 610 615 620 caa act gaa gaa aaa gtg ttg aaa gat ttg gaa aag ttg ggt tgg aag 1920 Gln Thr Glu Glu Lys Val Leu Lys Asp Leu Glu Lys Leu Gly Trp Lys 625 630 635 640 gat gaa taa 1929 Asp Glu <210> 238 <211> 642 <212> PRT <213> Saccharomyces cerevisiae <400> 238 Met Ser Ser Gln Phe Phe Leu Lys Thr Ser Gln Asp Ile Glu Leu Phe 1 5 10 15 Gln Ser Tyr Pro Thr Phe Glu Gln Ser Asn Thr Asn Ser Lys Asp Phe 20 25 30 Pro Val Ile Ser Ser Val Leu Ser Pro Cys Gly Arg Phe Leu Ala Leu 35 40 45 Ser Thr Lys Glu Asn Val Lys Val Phe Thr Gly Pro Cys Leu Asp Asn 50 55 60 Val Leu Leu Thr Met Lys Leu Ser Asp Val Tyr Asp Leu His Phe Ser 65 70 75 80 Pro Ala Gly Asn Tyr Leu Ser Thr Trp Glu Arg Ala Ser Ile Gln Asp 85 90 95 Pro Asn His Lys Asn Val Lys Val Trp Tyr Leu Asn Lys Pro Phe Lys 100 105 110 Lys Asp Cys Val Ser Glu Asp Ile Val Pro Ala Tyr Glu Tyr Gln Ala 115 120 125 Page 350 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Ser Gln Ser Gly Trp Phe Leu Gln Phe Ser Lys Leu Asp Asn Tyr 130 135 140 Gly Leu Arg Leu Phe Lys His Asp Leu Lys Ile Val Lys Leu Ser Ser 145 150 155 160 Ala Asn Ala Asp Asn Phe Asp Phe Gln Ser Pro Phe Ala Val Leu Ser 165 170 175 Asp Asp Glu Thr Ser Gln His Phe Thr Thr Tyr Leu Ile Ser Pro Ala 180 185 190 Glu His Pro Thr Ile Cys Thr Phe Thr Pro Glu Lys Gly Gly Lys Pro 195 200 205 Ala Gln Leu Ile Ile Trp Ala Leu Ser Glu Gly Lys Ile Thr Lys Lys 210 215 220 Ile Ala Ser Lys Thr Phe Phe Lys Ala Asp Ser Cys Gln Leu Lys Trp 225 230 235 240 Asn Pro Leu Gly Asn Ala Ile Leu Cys Leu Ala Ile Thr Asp Phe Asp 245 250 255 Ser Ser Asn Lys Ser Tyr Tyr Gly Glu Asn Thr Leu Tyr Leu Leu Ser 260 265 270 Phe Gln Gly Val Asn Gly Thr Leu Gly Gly Asn Ser Val Arg Val Ser 275 280 285 Leu Thr Thr Gly Pro Val His Asp Phe Thr Trp Ser Pro Thr Ser Arg 290 295 300 Gln Phe Gly Val Ile Ala Gly Tyr Met Pro Ala Thr Ile Ser Phe Phe 305 310 315 320 Asp Leu Arg Gly Asn Val Val His Ser Leu Pro Gln Gln Ala Lys Asn 325 330 335 Thr Met Leu Phe Ser Pro Ser Gly His Tyr Ile Leu Ile Ala Gly Phe 340 345 350 Gly Asn Leu Gln Gly Ser Val Glu Ile Leu Asp Arg Leu Asp Lys Phe 355 360 365 Lys Cys Val Ser Lys Phe Asp Ala Thr Asn Thr Ser Val Cys Lys Trp 370 375 380 Ser Pro Gly Gly Glu Phe Ile Met Thr Ala Thr Thr Ser Pro Arg Leu 385 390 395 400 Page 351 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Val Asp Asn Gly Val Lys Ile Trp His Val Ser Gly Ser Leu Val 405 410 415 Phe Val Lys Glu Phe Lys Glu Leu Leu Lys Val Asp Trp Arg Ser Pro 420 425 430 Cys Asn Tyr Lys Thr Leu Glu Asn Lys Asp Glu Ala Phe Phe Glu Asn 435 440 445 His Ile Ile Asn Asn Trp Glu Pro Leu Pro Asp Ser Thr Thr Ser Ser 450 455 460 Leu Asp Pro Lys Ile Ser Asn Lys Ser Glu Leu Gln Ile His Ser Ser 465 470 475 480 Val Gln Glu Tyr Ile Ser Gln His Pro Ser Arg Glu Ala Ser Ser Asn 485 490 495 Gly Asn Gly Ser Lys Ala Lys Ala Gly Gly Ala Tyr Lys Pro Pro His 500 505 510 Ala Arg Arg Thr Gly Gly Gly Arg Ile Val Pro Gly Val Pro Pro Gly 515 520 525 Ala Ala Lys Lys Thr Ile Pro Gly Leu Val Pro Gly Met Ser Ala Asn 530 535 540 Lys Asp Ala Asn Thr Lys Asn Arg Arg Arg Arg Ala Asn Lys Lys Ser 545 550 555 560 Ser Glu Thr Ser Pro Asp Ser Thr Pro Ala Pro Ser Ala Pro Ala Ser 565 570 575 Thr Asn Ala Pro Thr Asn Asn Lys Glu Thr Ser Pro Glu Glu Lys Lys 580 585 590 Ile Arg Ser Leu Leu Lys Lys Leu Arg Ala Ile Glu Thr Leu Lys Glu 595 600 605 Arg Gln Ala Val Gly Asp Lys Leu Glu Asp Thr Gln Val Leu Lys Ile 610 615 620 Gln Thr Glu Glu Lys Val Leu Lys Asp Leu Glu Lys Leu Gly Trp Lys 625 630 635 640 Asp Glu <210> 239 <211> 450 <212> DNA Page 352 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(450) <400> 239 atg tca gcc acc aga gcc aat aaa gat att ttc aca cta ttc gac aag 48 Met Ser Ala Thr Arg Ala Asn Lys Asp Ile Phe Thr Leu Phe Asp Lys 1 5 10 15 aag ggt caa ggc gcc att gcc aag gat tcc ttg gga gat tac ctg agg 96 Lys Gly Gln Gly Ala Ile Ala Lys Asp Ser Leu Gly Asp Tyr Leu Arg 20 25 30 gca att ggc tac aac ccc acc aac cag ctc gta cag gac atc ata aac 144 Ala Ile Gly Tyr Asn Pro Thr Asn Gln Leu Val Gln Asp Ile Ile Asn 35 40 45 gcg gat tcg agc ttg aga gac gcc tct agc ttg acg ctg gac cag att 192 Ala Asp Ser Ser Leu Arg Asp Ala Ser Ser Leu Thr Leu Asp Gln Ile 50 55 60 aca ggc cta att gaa gtc aac gaa aag gaa ttg gat gca act acc aag 240 Thr Gly Leu Ile Glu Val Asn Glu Lys Glu Leu Asp Ala Thr Thr Lys 65 70 75 80 gca aag aca gaa gac ttc gtc aag gca ttc cag gtc ttc gac aag gaa 288 Ala Lys Thr Glu Asp Phe Val Lys Ala Phe Gln Val Phe Asp Lys Glu 85 90 95 agt aca ggc aag gta tcc gtt ggt gac tta agg tac atg cta act ggc 336 Ser Thr Gly Lys Val Ser Val Gly Asp Leu Arg Tyr Met Leu Thr Gly 100 105 110 ttg ggt gaa aag tta acc gac gct gaa gta gac gag ctg ttg aag ggt 384 Leu Gly Glu Lys Leu Thr Asp Ala Glu Val Asp Glu Leu Leu Lys Gly 115 120 125 gtt gaa gtg gac agc aac gga gaa att gac tac aag aag ttc atc gaa 432 Val Glu Val Asp Ser Asn Gly Glu Ile Asp Tyr Lys Lys Phe Ile Glu 130 135 140 gat gtt ttg aga caa tga 450 Asp Val Leu Arg Gln 145 <210> 240 <211> 149 <212> PRT <213> Saccharomyces cerevisiae <400> 240 Met Ser Ala Thr Arg Ala Asn Lys Asp Ile Phe Thr Leu Phe Asp Lys 1 5 10 15 Lys Gly Gln Gly Ala Ile Ala Lys Asp Ser Leu Gly Asp Tyr Leu Arg 20 25 30 Ala Ile Gly Tyr Asn Pro Thr Asn Gln Leu Val Gln Asp Ile Ile Asn 35 40 45 Page 353 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Asp Ser Ser Leu Arg Asp Ala Ser Ser Leu Thr Leu Asp Gln Ile 50 55 60 Thr Gly Leu Ile Glu Val Asn Glu Lys Glu Leu Asp Ala Thr Thr Lys 65 70 75 80 Ala Lys Thr Glu Asp Phe Val Lys Ala Phe Gln Val Phe Asp Lys Glu 85 90 95 Ser Thr Gly Lys Val Ser Val Gly Asp Leu Arg Tyr Met Leu Thr Gly 100 105 110 Leu Gly Glu Lys Leu Thr Asp Ala Glu Val Asp Glu Leu Leu Lys Gly 115 120 125 Val Glu Val Asp Ser Asn Gly Glu Ile Asp Tyr Lys Lys Phe Ile Glu 130 135 140 Asp Val Leu Arg Gln 145 <210> 241 <211> 1782 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1782) <400> 241 atg tat tca att gtt aaa gag att att gta gat cct tac aaa aga cta 48 Met Tyr Ser Ile Val Lys Glu Ile Ile Val Asp Pro Tyr Lys Arg Leu 1 5 10 15 aaa tgg ggt ttt att cca gta aag cgg cag gtg gaa gac ctg cca gat 96 Lys Trp Gly Phe Ile Pro Val Lys Arg Gln Val Glu Asp Leu Pro Asp 20 25 30 gac tta aat tca aca gaa att gtc act atc tcc aac agt atc cag agt 144 Asp Leu Asn Ser Thr Glu Ile Val Thr Ile Ser Asn Ser Ile Gln Ser 35 40 45 cat gaa aca gct gaa aat ttc atc acg act aca agt gaa aaa gat caa 192 His Glu Thr Ala Glu Asn Phe Ile Thr Thr Thr Ser Glu Lys Asp Gln 50 55 60 cta cat ttt gag act agt agc tat agt gaa cat aaa gac aat gtg aac 240 Leu His Phe Glu Thr Ser Ser Tyr Ser Glu His Lys Asp Asn Val Asn 65 70 75 80 gtt act aga agt tat gaa tat aga gat gaa gcc gat agg cca tgg tgg 288 Val Thr Arg Ser Tyr Glu Tyr Arg Asp Glu Ala Asp Arg Pro Trp Trp 85 90 95 aga ttt ttc gat gaa caa gag tat cgg atc aat gaa aag gaa aga tct 336 Arg Phe Phe Asp Glu Gln Glu Tyr Arg Ile Asn Glu Lys Glu Arg Ser 100 105 110 cac aat aaa tgg tat agt tgg ttc aaa cag ggt acc tct ttc aaa gaa 384 Page 354 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt His Asn Lys Trp Tyr Ser Trp Phe Lys Gln Gly Thr Ser Phe Lys Glu 115 120 125 aaa aaa tta tta att aaa ttg gat gtc ctt tta gcc ttt tat tct tgt 432 Lys Lys Leu Leu Ile Lys Leu Asp Val Leu Leu Ala Phe Tyr Ser Cys 130 135 140 att gct tat tgg gtg aaa tat ctg gat acg gtt aat ata aac aac gct 480 Ile Ala Tyr Trp Val Lys Tyr Leu Asp Thr Val Asn Ile Asn Asn Ala 145 150 155 160 tac gtt tcg gga atg aag gaa gat tta ggc ttt caa ggt aat gat ttg 528 Tyr Val Ser Gly Met Lys Glu Asp Leu Gly Phe Gln Gly Asn Asp Leu 165 170 175 gtg cat act caa gta atg tac aca gtt ggt aat att ata ttt caa ttg 576 Val His Thr Gln Val Met Tyr Thr Val Gly Asn Ile Ile Phe Gln Leu 180 185 190 cca ttt ttg att tac ctg aac aag ctc cca tta aac tat gtt tta cca 624 Pro Phe Leu Ile Tyr Leu Asn Lys Leu Pro Leu Asn Tyr Val Leu Pro 195 200 205 agc ctc gac tta tgt tgg tcg ctt tta acc gtt ggt gct gca tat gtc 672 Ser Leu Asp Leu Cys Trp Ser Leu Leu Thr Val Gly Ala Ala Tyr Val 210 215 220 aat tct gta cca cac ttg aaa gca att agg ttt ttc att ggg gct ttt 720 Asn Ser Val Pro His Leu Lys Ala Ile Arg Phe Phe Ile Gly Ala Phe 225 230 235 240 gaa gcg cca agt tat ttg gca tac caa tat ttg ttt ggt tcc ttt tac 768 Glu Ala Pro Ser Tyr Leu Ala Tyr Gln Tyr Leu Phe Gly Ser Phe Tyr 245 250 255 aaa cat gat gaa atg gtg cgt cgt tct gct ttt tac tat ttg ggc cag 816 Lys His Asp Glu Met Val Arg Arg Ser Ala Phe Tyr Tyr Leu Gly Gln 260 265 270 tat atc ggt att cta tcc gct ggt ggg atc cag tca gcc gta tat tca 864 Tyr Ile Gly Ile Leu Ser Ala Gly Gly Ile Gln Ser Ala Val Tyr Ser 275 280 285 tcg tta aat ggt gta aat ggt tta gag gga tgg aga tgg aac ttt att 912 Ser Leu Asn Gly Val Asn Gly Leu Glu Gly Trp Arg Trp Asn Phe Ile 290 295 300 att gac gct att gtg tct gtc gta gtg ggc ctt att gga ttt tac tcc 960 Ile Asp Ala Ile Val Ser Val Val Val Gly Leu Ile Gly Phe Tyr Ser 305 310 315 320 ctg cca ggt gac cca tac aac tgt tat tct att ttc tta act gat gat 1008 Leu Pro Gly Asp Pro Tyr Asn Cys Tyr Ser Ile Phe Leu Thr Asp Asp 325 330 335 gaa att agg ttg gcg agg aaa aga tta aaa gaa aac caa aca ggt aaa 1056 Glu Ile Arg Leu Ala Arg Lys Arg Leu Lys Glu Asn Gln Thr Gly Lys 340 345 350 agt gat ttt gaa aca aaa gta ttc gat att aaa ctg tgg aaa aca att 1104 Ser Asp Phe Glu Thr Lys Val Phe Asp Ile Lys Leu Trp Lys Thr Ile 355 360 365 ttc agt gat tgg aaa ata tac att tta act tta tgg aat att ttc tgt 1152 Phe Ser Asp Trp Lys Ile Tyr Ile Leu Thr Leu Trp Asn Ile Phe Cys 370 375 380 tgg aat gac agt aat gtt tca tct ggg gca tac cta cta tgg ttg aaa 1200 Page 355 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Trp Asn Asp Ser Asn Val Ser Ser Gly Ala Tyr Leu Leu Trp Leu Lys 385 390 395 400 tct ttg aaa aga tac tct att cct aag ctc aat cag tta tcc atg att 1248 Ser Leu Lys Arg Tyr Ser Ile Pro Lys Leu Asn Gln Leu Ser Met Ile 405 410 415 act ccg ggt tta ggt atg gtt tat ttg atg ctt act ggt att att gca 1296 Thr Pro Gly Leu Gly Met Val Tyr Leu Met Leu Thr Gly Ile Ile Ala 420 425 430 gat aaa tta cac tct cgt tgg ttt gcg att att ttt act cag gtt ttc 1344 Asp Lys Leu His Ser Arg Trp Phe Ala Ile Ile Phe Thr Gln Val Phe 435 440 445 aat atc att ggt aac tcc ata tta gcc gct tgg gac gtc gca gaa gga 1392 Asn Ile Ile Gly Asn Ser Ile Leu Ala Ala Trp Asp Val Ala Glu Gly 450 455 460 gcc aaa tgg ttt gca ttt atg ctg caa tgt ttt ggt tgg gct atg gct 1440 Ala Lys Trp Phe Ala Phe Met Leu Gln Cys Phe Gly Trp Ala Met Ala 465 470 475 480 cct gtt tta tac tct tgg caa aac gat att tgt cgc cga gat gct caa 1488 Pro Val Leu Tyr Ser Trp Gln Asn Asp Ile Cys Arg Arg Asp Ala Gln 485 490 495 act aga gct att act tta gtt aca atg aat att atg gct caa tca tct 1536 Thr Arg Ala Ile Thr Leu Val Thr Met Asn Ile Met Ala Gln Ser Ser 500 505 510 acc gca tgg ata agt gtt ttg gtt tgg aaa aca gaa gaa gct ccc agg 1584 Thr Ala Trp Ile Ser Val Leu Val Trp Lys Thr Glu Glu Ala Pro Arg 515 520 525 tat tta aag ggg ttt act ttc act gca tgt tct gct ttt tgt ctc tcc 1632 Tyr Leu Lys Gly Phe Thr Phe Thr Ala Cys Ser Ala Phe Cys Leu Ser 530 535 540 att tgg act ttt gtt gta ctc tac ttc tat aaa cgt gat gaa agg aac 1680 Ile Trp Thr Phe Val Val Leu Tyr Phe Tyr Lys Arg Asp Glu Arg Asn 545 550 555 560 aat gcc aag aag aac ggt att gtg ctt tat aac tct aaa cat ggt gtg 1728 Asn Ala Lys Lys Asn Gly Ile Val Leu Tyr Asn Ser Lys His Gly Val 565 570 575 gaa aag cca acg tca aaa gac gtt gaa acc tta tca gta tct gat gaa 1776 Glu Lys Pro Thr Ser Lys Asp Val Glu Thr Leu Ser Val Ser Asp Glu 580 585 590 aaa taa 1782 Lys <210> 242 <211> 593 <212> PRT <213> Saccharomyces cerevisiae <400> 242 Met Tyr Ser Ile Val Lys Glu Ile Ile Val Asp Pro Tyr Lys Arg Leu 1 5 10 15 Lys Trp Gly Phe Ile Pro Val Lys Arg Gln Val Glu Asp Leu Pro Asp Page 356 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 Asp Leu Asn Ser Thr Glu Ile Val Thr Ile Ser Asn Ser Ile Gln Ser 35 40 45 His Glu Thr Ala Glu Asn Phe Ile Thr Thr Thr Ser Glu Lys Asp Gln 50 55 60 Leu His Phe Glu Thr Ser Ser Tyr Ser Glu His Lys Asp Asn Val Asn 65 70 75 80 Val Thr Arg Ser Tyr Glu Tyr Arg Asp Glu Ala Asp Arg Pro Trp Trp 85 90 95 Arg Phe Phe Asp Glu Gln Glu Tyr Arg Ile Asn Glu Lys Glu Arg Ser 100 105 110 His Asn Lys Trp Tyr Ser Trp Phe Lys Gln Gly Thr Ser Phe Lys Glu 115 120 125 Lys Lys Leu Leu Ile Lys Leu Asp Val Leu Leu Ala Phe Tyr Ser Cys 130 135 140 Ile Ala Tyr Trp Val Lys Tyr Leu Asp Thr Val Asn Ile Asn Asn Ala 145 150 155 160 Tyr Val Ser Gly Met Lys Glu Asp Leu Gly Phe Gln Gly Asn Asp Leu 165 170 175 Val His Thr Gln Val Met Tyr Thr Val Gly Asn Ile Ile Phe Gln Leu 180 185 190 Pro Phe Leu Ile Tyr Leu Asn Lys Leu Pro Leu Asn Tyr Val Leu Pro 195 200 205 Ser Leu Asp Leu Cys Trp Ser Leu Leu Thr Val Gly Ala Ala Tyr Val 210 215 220 Asn Ser Val Pro His Leu Lys Ala Ile Arg Phe Phe Ile Gly Ala Phe 225 230 235 240 Glu Ala Pro Ser Tyr Leu Ala Tyr Gln Tyr Leu Phe Gly Ser Phe Tyr 245 250 255 Lys His Asp Glu Met Val Arg Arg Ser Ala Phe Tyr Tyr Leu Gly Gln 260 265 270 Tyr Ile Gly Ile Leu Ser Ala Gly Gly Ile Gln Ser Ala Val Tyr Ser 275 280 285 Ser Leu Asn Gly Val Asn Gly Leu Glu Gly Trp Arg Trp Asn Phe Ile Page 357 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 290 295 300 Ile Asp Ala Ile Val Ser Val Val Val Gly Leu Ile Gly Phe Tyr Ser 305 310 315 320 Leu Pro Gly Asp Pro Tyr Asn Cys Tyr Ser Ile Phe Leu Thr Asp Asp 325 330 335 Glu Ile Arg Leu Ala Arg Lys Arg Leu Lys Glu Asn Gln Thr Gly Lys 340 345 350 Ser Asp Phe Glu Thr Lys Val Phe Asp Ile Lys Leu Trp Lys Thr Ile 355 360 365 Phe Ser Asp Trp Lys Ile Tyr Ile Leu Thr Leu Trp Asn Ile Phe Cys 370 375 380 Trp Asn Asp Ser Asn Val Ser Ser Gly Ala Tyr Leu Leu Trp Leu Lys 385 390 395 400 Ser Leu Lys Arg Tyr Ser Ile Pro Lys Leu Asn Gln Leu Ser Met Ile 405 410 415 Thr Pro Gly Leu Gly Met Val Tyr Leu Met Leu Thr Gly Ile Ile Ala 420 425 430 Asp Lys Leu His Ser Arg Trp Phe Ala Ile Ile Phe Thr Gln Val Phe 435 440 445 Asn Ile Ile Gly Asn Ser Ile Leu Ala Ala Trp Asp Val Ala Glu Gly 450 455 460 Ala Lys Trp Phe Ala Phe Met Leu Gln Cys Phe Gly Trp Ala Met Ala 465 470 475 480 Pro Val Leu Tyr Ser Trp Gln Asn Asp Ile Cys Arg Arg Asp Ala Gln 485 490 495 Thr Arg Ala Ile Thr Leu Val Thr Met Asn Ile Met Ala Gln Ser Ser 500 505 510 Thr Ala Trp Ile Ser Val Leu Val Trp Lys Thr Glu Glu Ala Pro Arg 515 520 525 Tyr Leu Lys Gly Phe Thr Phe Thr Ala Cys Ser Ala Phe Cys Leu Ser 530 535 540 Ile Trp Thr Phe Val Val Leu Tyr Phe Tyr Lys Arg Asp Glu Arg Asn 545 550 555 560 Asn Ala Lys Lys Asn Gly Ile Val Leu Tyr Asn Ser Lys His Gly Val Page 358 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 565 570 575 Glu Lys Pro Thr Ser Lys Asp Val Glu Thr Leu Ser Val Ser Asp Glu 580 585 590 Lys <210> 243 <211> 1041 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1041) <400> 243 atg aag gcg tcg cac att tgc tct tat ttg cta agc att gca ccc cta 48 Met Lys Ala Ser His Ile Cys Ser Tyr Leu Leu Ser Ile Ala Pro Leu 1 5 10 15 gtg gtg tcc cat gga gta cat cat aat cga gat cat ggc cac gag gca 96 Val Val Ser His Gly Val His His Asn Arg Asp His Gly His Glu Ala 20 25 30 aac cat gag tcc aag caa agt ttc ttg att ttg aag caa gaa tcc att 144 Asn His Glu Ser Lys Gln Ser Phe Leu Ile Leu Lys Gln Glu Ser Ile 35 40 45 ttt tac tct cta gtt tgc ttt ctg cag aac cac ctc ttt gtc ctg gga 192 Phe Tyr Ser Leu Val Cys Phe Leu Gln Asn His Leu Phe Val Leu Gly 50 55 60 ccc cgt tac aat gcg att gtg gct atc cta atc ata caa ctt atg ccg 240 Pro Arg Tyr Asn Ala Ile Val Ala Ile Leu Ile Ile Gln Leu Met Pro 65 70 75 80 tgt ctt ttc gta ctg ttt gtt cct gga ctg cgc aag aac gat cgt gcc 288 Cys Leu Phe Val Leu Phe Val Pro Gly Leu Arg Lys Asn Asp Arg Ala 85 90 95 agc ttg aca ctg tcc tta cta gtt tcc ttt tct cta gga aca ctc ctg 336 Ser Leu Thr Leu Ser Leu Leu Val Ser Phe Ser Leu Gly Thr Leu Leu 100 105 110 ggt gat att tta tta cac gtg ata cct gaa agt ctc agc ggc gta act 384 Gly Asp Ile Leu Leu His Val Ile Pro Glu Ser Leu Ser Gly Val Thr 115 120 125 gat gtc aca atg gtt gga gga gcc ata ttt ctg ggg ttt ata agc ttc 432 Asp Val Thr Met Val Gly Gly Ala Ile Phe Leu Gly Phe Ile Ser Phe 130 135 140 ttg act ctg gat aaa acg atg cgt att ctg tca ggg acg tcc aac gat 480 Leu Thr Leu Asp Lys Thr Met Arg Ile Leu Ser Gly Thr Ser Asn Asp 145 150 155 160 gac ggc agc ata cat tct cat tct cat agt cat act cca caa caa act 528 Asp Gly Ser Ile His Ser His Ser His Ser His Thr Pro Gln Gln Thr 165 170 175 gca gag aag aaa gcg ggc ttt aac atg tct gcg tat ctg aat gtc ata 576 Ala Glu Lys Lys Ala Gly Phe Asn Met Ser Ala Tyr Leu Asn Val Ile Page 359 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 180 185 190 tcc ggc att gct cat cac atc acg gat ggc ata gcg ctg gct acg tca 624 Ser Gly Ile Ala His His Ile Thr Asp Gly Ile Ala Leu Ala Thr Ser 195 200 205 ttc tat agt tcc aca caa gtt ggc ata atg acc agc ata gct gtc act 672 Phe Tyr Ser Ser Thr Gln Val Gly Ile Met Thr Ser Ile Ala Val Thr 210 215 220 ttc cat gag atc cct cat gag cta ggt gac ttc gcc att ctg ctt tcc 720 Phe His Glu Ile Pro His Glu Leu Gly Asp Phe Ala Ile Leu Leu Ser 225 230 235 240 agt ggg ttt acg ttc cca caa gcg ata aga gcc caa gcg gtg aca gct 768 Ser Gly Phe Thr Phe Pro Gln Ala Ile Arg Ala Gln Ala Val Thr Ala 245 250 255 ttc ggc gcc gtc gtt gga acg tcc att ggc tgc tgg atg aac gaa atc 816 Phe Gly Ala Val Val Gly Thr Ser Ile Gly Cys Trp Met Asn Glu Ile 260 265 270 ggg aac aac agc cat aaa gca acg tct tca tcc gcg aac gca tct gaa 864 Gly Asn Asn Ser His Lys Ala Thr Ser Ser Ser Ala Asn Ala Ser Glu 275 280 285 ctt atg ctg ccg ttc acg gcg ggc ggc ctc ata tac ata gcc act act 912 Leu Met Leu Pro Phe Thr Ala Gly Gly Leu Ile Tyr Ile Ala Thr Thr 290 295 300 agc gtt gta ccg cag atc tta cat agc tcc gca ccc gat agc aag ctt 960 Ser Val Val Pro Gln Ile Leu His Ser Ser Ala Pro Asp Ser Lys Leu 305 310 315 320 cga gag ttt aag aag tgg gcc ttg cag cta gtc ttc att ttt gta gga 1008 Arg Glu Phe Lys Lys Trp Ala Leu Gln Leu Val Phe Ile Phe Val Gly 325 330 335 ttt gcc gtt atg gcg ctc atg gat gag cat tga 1041 Phe Ala Val Met Ala Leu Met Asp Glu His 340 345 <210> 244 <211> 346 <212> PRT <213> Saccharomyces cerevisiae <400> 244 Met Lys Ala Ser His Ile Cys Ser Tyr Leu Leu Ser Ile Ala Pro Leu 1 5 10 15 Val Val Ser His Gly Val His His Asn Arg Asp His Gly His Glu Ala 20 25 30 Asn His Glu Ser Lys Gln Ser Phe Leu Ile Leu Lys Gln Glu Ser Ile 35 40 45 Phe Tyr Ser Leu Val Cys Phe Leu Gln Asn His Leu Phe Val Leu Gly 50 55 60 Pro Arg Tyr Asn Ala Ile Val Ala Ile Leu Ile Ile Gln Leu Met Pro 65 70 75 80 Page 360 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Cys Leu Phe Val Leu Phe Val Pro Gly Leu Arg Lys Asn Asp Arg Ala 85 90 95 Ser Leu Thr Leu Ser Leu Leu Val Ser Phe Ser Leu Gly Thr Leu Leu 100 105 110 Gly Asp Ile Leu Leu His Val Ile Pro Glu Ser Leu Ser Gly Val Thr 115 120 125 Asp Val Thr Met Val Gly Gly Ala Ile Phe Leu Gly Phe Ile Ser Phe 130 135 140 Leu Thr Leu Asp Lys Thr Met Arg Ile Leu Ser Gly Thr Ser Asn Asp 145 150 155 160 Asp Gly Ser Ile His Ser His Ser His Ser His Thr Pro Gln Gln Thr 165 170 175 Ala Glu Lys Lys Ala Gly Phe Asn Met Ser Ala Tyr Leu Asn Val Ile 180 185 190 Ser Gly Ile Ala His His Ile Thr Asp Gly Ile Ala Leu Ala Thr Ser 195 200 205 Phe Tyr Ser Ser Thr Gln Val Gly Ile Met Thr Ser Ile Ala Val Thr 210 215 220 Phe His Glu Ile Pro His Glu Leu Gly Asp Phe Ala Ile Leu Leu Ser 225 230 235 240 Ser Gly Phe Thr Phe Pro Gln Ala Ile Arg Ala Gln Ala Val Thr Ala 245 250 255 Phe Gly Ala Val Val Gly Thr Ser Ile Gly Cys Trp Met Asn Glu Ile 260 265 270 Gly Asn Asn Ser His Lys Ala Thr Ser Ser Ser Ala Asn Ala Ser Glu 275 280 285 Leu Met Leu Pro Phe Thr Ala Gly Gly Leu Ile Tyr Ile Ala Thr Thr 290 295 300 Ser Val Val Pro Gln Ile Leu His Ser Ser Ala Pro Asp Ser Lys Leu 305 310 315 320 Arg Glu Phe Lys Lys Trp Ala Leu Gln Leu Val Phe Ile Phe Val Gly 325 330 335 Phe Ala Val Met Ala Leu Met Asp Glu His 340 345 Page 361 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 245 <211> 429 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(429) <400> 245 atg gat atg gta tca cca gtc ttg aac cta caa tca tct att tta ggt 48 Met Asp Met Val Ser Pro Val Leu Asn Leu Gln Ser Ser Ile Leu Gly 1 5 10 15 gag ctc gta ggc att att gga aaa gtg ttc ttt ctc tta ata gaa gag 96 Glu Leu Val Gly Ile Ile Gly Lys Val Phe Phe Leu Leu Ile Glu Glu 20 25 30 att aaa tac ccg ata atc aca ccc aaa att att gtg gat gcc cag ata 144 Ile Lys Tyr Pro Ile Ile Thr Pro Lys Ile Ile Val Asp Ala Gln Ile 35 40 45 tct tct tgg tca ttg ttt ttt ttc gct tca atc tgt aat ctc tct gca 192 Ser Ser Trp Ser Leu Phe Phe Phe Ala Ser Ile Cys Asn Leu Ser Ala 50 55 60 aaa ttt cgg gag cca ata gtg aca aca tcg tca ata ata agt ttg atg 240 Lys Phe Arg Glu Pro Ile Val Thr Thr Ser Ser Ile Ile Ser Leu Met 65 70 75 80 gaa tcg gaa aaa gat ctt aaa aat gta aat gag tat ttc caa ata atg 288 Glu Ser Glu Lys Asp Leu Lys Asn Val Asn Glu Tyr Phe Gln Ile Met 85 90 95 gcc aaa atg ctc ttt ata ttg gaa aat aaa ata gtt gtt tcg ctc ttc 336 Ala Lys Met Leu Phe Ile Leu Glu Asn Lys Ile Val Val Ser Leu Phe 100 105 110 gta gta ttt aac att tcc gtt ctt atc att gta aag tct gag cca tat 384 Val Val Phe Asn Ile Ser Val Leu Ile Ile Val Lys Ser Glu Pro Tyr 115 120 125 tca tat gga aaa gtg ctt ttt aaa cct agt tcc tcc ata ttt tag 429 Ser Tyr Gly Lys Val Leu Phe Lys Pro Ser Ser Ser Ile Phe 130 135 140 <210> 246 <211> 142 <212> PRT <213> Saccharomyces cerevisiae <400> 246 Met Asp Met Val Ser Pro Val Leu Asn Leu Gln Ser Ser Ile Leu Gly 1 5 10 15 Glu Leu Val Gly Ile Ile Gly Lys Val Phe Phe Leu Leu Ile Glu Glu 20 25 30 Ile Lys Tyr Pro Ile Ile Thr Pro Lys Ile Ile Val Asp Ala Gln Ile 35 40 45 Page 362 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Ser Trp Ser Leu Phe Phe Phe Ala Ser Ile Cys Asn Leu Ser Ala 50 55 60 Lys Phe Arg Glu Pro Ile Val Thr Thr Ser Ser Ile Ile Ser Leu Met 65 70 75 80 Glu Ser Glu Lys Asp Leu Lys Asn Val Asn Glu Tyr Phe Gln Ile Met 85 90 95 Ala Lys Met Leu Phe Ile Leu Glu Asn Lys Ile Val Val Ser Leu Phe 100 105 110 Val Val Phe Asn Ile Ser Val Leu Ile Ile Val Lys Ser Glu Pro Tyr 115 120 125 Ser Tyr Gly Lys Val Leu Phe Lys Pro Ser Ser Ser Ile Phe 130 135 140 <210> 247 <211> 1167 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(1167) <400> 247 gtg aaa cat ctg cat cga ttc ttt agc agt gat gcc tcg gga ggc att 48 Val Lys His Leu His Arg Phe Phe Ser Ser Asp Ala Ser Gly Gly Ile 1 5 10 15 att ctt atc att gcc gct atc ctg gcg atg att atg gcc aac agc ggc 96 Ile Leu Ile Ile Ala Ala Ile Leu Ala Met Ile Met Ala Asn Ser Gly 20 25 30 gca acc agt gga tgg tat cac gac ttt ctg gag acg ccg gtt cag ctc 144 Ala Thr Ser Gly Trp Tyr His Asp Phe Leu Glu Thr Pro Val Gln Leu 35 40 45 cgg gtt ggt tca ctc gaa atc aac aaa aac atg ctg tta tgg ata aat 192 Arg Val Gly Ser Leu Glu Ile Asn Lys Asn Met Leu Leu Trp Ile Asn 50 55 60 gac gcg ctg atg gcg gta ttt ttc ctg tta gtc ggt ctg gaa gtt aaa 240 Asp Ala Leu Met Ala Val Phe Phe Leu Leu Val Gly Leu Glu Val Lys 65 70 75 80 cgt gaa ctg atg caa gga tcg cta gcc agc tta cgc cag gcc gca ttt 288 Arg Glu Leu Met Gln Gly Ser Leu Ala Ser Leu Arg Gln Ala Ala Phe 85 90 95 cca gtt atc gcc gct att ggt ggg atg att gtg ccg gca tta ctc tat 336 Pro Val Ile Ala Ala Ile Gly Gly Met Ile Val Pro Ala Leu Leu Tyr 100 105 110 ctg gct ttt aac tat gcc gat ccg att acc cgc gaa ggg tgg gcg atc 384 Leu Ala Phe Asn Tyr Ala Asp Pro Ile Thr Arg Glu Gly Trp Ala Ile 115 120 125 Page 363 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ccg gcg gct act gac att gct ttt gca ctt ggt gta ctg gcg ctg ttg 432 Pro Ala Ala Thr Asp Ile Ala Phe Ala Leu Gly Val Leu Ala Leu Leu 130 135 140 gga agt cgt gtt ccg tta gcg ctg aag atc ttt ttg atg gct ctg gct 480 Gly Ser Arg Val Pro Leu Ala Leu Lys Ile Phe Leu Met Ala Leu Ala 145 150 155 160 att atc gac gat ctt ggg gcc atc att atc atc gca ttg ttc tac act 528 Ile Ile Asp Asp Leu Gly Ala Ile Ile Ile Ile Ala Leu Phe Tyr Thr 165 170 175 aat gac tta tcg atg gcc tct ctt ggc gtc gcg gct gta gca att gcg 576 Asn Asp Leu Ser Met Ala Ser Leu Gly Val Ala Ala Val Ala Ile Ala 180 185 190 gta ctc gcg gta ttg aat ctg tgt ggt gca cgc cgc acg ggc gtc tat 624 Val Leu Ala Val Leu Asn Leu Cys Gly Ala Arg Arg Thr Gly Val Tyr 195 200 205 att ctt gtt ggc gtg gtg ttg tgg act gcg gtg ttg aaa tcg ggg gtt 672 Ile Leu Val Gly Val Val Leu Trp Thr Ala Val Leu Lys Ser Gly Val 210 215 220 cac gca act ctg gcg ggg gta att gtc ggc ttc ttt att cct ttg aaa 720 His Ala Thr Leu Ala Gly Val Ile Val Gly Phe Phe Ile Pro Leu Lys 225 230 235 240 gag aag cat ggg cgt tct cca gcg aag cga ctg gag cat gtg ttg cac 768 Glu Lys His Gly Arg Ser Pro Ala Lys Arg Leu Glu His Val Leu His 245 250 255 ccg tgg gtg gcg tat ctg att ttg ccg ctg ttt gca ttt gct aat gct 816 Pro Trp Val Ala Tyr Leu Ile Leu Pro Leu Phe Ala Phe Ala Asn Ala 260 265 270 ggc gtt tca ctg caa ggc gtc acg ctg gat ggc ttg acc tcc att ctg 864 Gly Val Ser Leu Gln Gly Val Thr Leu Asp Gly Leu Thr Ser Ile Leu 275 280 285 cca ttg ggg atc atc gct ggc ttg ctg att ggc aaa ccg ctg ggg att 912 Pro Leu Gly Ile Ile Ala Gly Leu Leu Ile Gly Lys Pro Leu Gly Ile 290 295 300 agt ctg ttc tgc tgg ttg gcg ctg cgt ttg aaa ctg gcg cat ctg cct 960 Ser Leu Phe Cys Trp Leu Ala Leu Arg Leu Lys Leu Ala His Leu Pro 305 310 315 320 gag gga acg act tat cag caa att atg gtg gtg ggg atc ctg tgc ggt 1008 Glu Gly Thr Thr Tyr Gln Gln Ile Met Val Val Gly Ile Leu Cys Gly 325 330 335 atc ggt ttt act atg tct atc ttt att gcc agc ctg gcc ttt ggt agc 1056 Ile Gly Phe Thr Met Ser Ile Phe Ile Ala Ser Leu Ala Phe Gly Ser 340 345 350 gta gat cca gaa ctg att aac tgg gcg aaa ctc ggt atc ctg gtc ggt 1104 Val Asp Pro Glu Leu Ile Asn Trp Ala Lys Leu Gly Ile Leu Val Gly 355 360 365 tct atc tct tcg gcg gta att gga tac agc tgg tta cgc gtt cgt ttg 1152 Ser Ile Ser Ser Ala Val Ile Gly Tyr Ser Trp Leu Arg Val Arg Leu 370 375 380 cgt cca tca gtt tga 1167 Arg Pro Ser Val 385 Page 364 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 248 <211> 388 <212> PRT <213> Escherichia coli <400> 248 Val Lys His Leu His Arg Phe Phe Ser Ser Asp Ala Ser Gly Gly Ile 1 5 10 15 Ile Leu Ile Ile Ala Ala Ile Leu Ala Met Ile Met Ala Asn Ser Gly 20 25 30 Ala Thr Ser Gly Trp Tyr His Asp Phe Leu Glu Thr Pro Val Gln Leu 35 40 45 Arg Val Gly Ser Leu Glu Ile Asn Lys Asn Met Leu Leu Trp Ile Asn 50 55 60 Asp Ala Leu Met Ala Val Phe Phe Leu Leu Val Gly Leu Glu Val Lys 65 70 75 80 Arg Glu Leu Met Gln Gly Ser Leu Ala Ser Leu Arg Gln Ala Ala Phe 85 90 95 Pro Val Ile Ala Ala Ile Gly Gly Met Ile Val Pro Ala Leu Leu Tyr 100 105 110 Leu Ala Phe Asn Tyr Ala Asp Pro Ile Thr Arg Glu Gly Trp Ala Ile 115 120 125 Pro Ala Ala Thr Asp Ile Ala Phe Ala Leu Gly Val Leu Ala Leu Leu 130 135 140 Gly Ser Arg Val Pro Leu Ala Leu Lys Ile Phe Leu Met Ala Leu Ala 145 150 155 160 Ile Ile Asp Asp Leu Gly Ala Ile Ile Ile Ile Ala Leu Phe Tyr Thr 165 170 175 Asn Asp Leu Ser Met Ala Ser Leu Gly Val Ala Ala Val Ala Ile Ala 180 185 190 Val Leu Ala Val Leu Asn Leu Cys Gly Ala Arg Arg Thr Gly Val Tyr 195 200 205 Ile Leu Val Gly Val Val Leu Trp Thr Ala Val Leu Lys Ser Gly Val 210 215 220 His Ala Thr Leu Ala Gly Val Ile Val Gly Phe Phe Ile Pro Leu Lys 225 230 235 240 Page 365 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Lys His Gly Arg Ser Pro Ala Lys Arg Leu Glu His Val Leu His 245 250 255 Pro Trp Val Ala Tyr Leu Ile Leu Pro Leu Phe Ala Phe Ala Asn Ala 260 265 270 Gly Val Ser Leu Gln Gly Val Thr Leu Asp Gly Leu Thr Ser Ile Leu 275 280 285 Pro Leu Gly Ile Ile Ala Gly Leu Leu Ile Gly Lys Pro Leu Gly Ile 290 295 300 Ser Leu Phe Cys Trp Leu Ala Leu Arg Leu Lys Leu Ala His Leu Pro 305 310 315 320 Glu Gly Thr Thr Tyr Gln Gln Ile Met Val Val Gly Ile Leu Cys Gly 325 330 335 Ile Gly Phe Thr Met Ser Ile Phe Ile Ala Ser Leu Ala Phe Gly Ser 340 345 350 Val Asp Pro Glu Leu Ile Asn Trp Ala Lys Leu Gly Ile Leu Val Gly 355 360 365 Ser Ile Ser Ser Ala Val Ile Gly Tyr Ser Trp Leu Arg Val Arg Leu 370 375 380 Arg Pro Ser Val 385 <210> 249 <211> 1011 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(1011) <400> 249 atg agt gcg tta aat aag aaa agt ttt ctt act tac ctg aaa gag ggc 48 Met Ser Ala Leu Asn Lys Lys Ser Phe Leu Thr Tyr Leu Lys Glu Gly 1 5 10 15 ggt att tac gtc gtt ctt tta gtt ttg ctg gcg att att att ttc cag 96 Gly Ile Tyr Val Val Leu Leu Val Leu Leu Ala Ile Ile Ile Phe Gln 20 25 30 gac cca aca ttt tta agt ctg ttg aac tta agt aat att ctc acc cag 144 Asp Pro Thr Phe Leu Ser Leu Leu Asn Leu Ser Asn Ile Leu Thr Gln 35 40 45 tca tcg gtg cgt att att atc gcg ctc ggt gtg gca ggg tta att gtc 192 Ser Ser Val Arg Ile Ile Ile Ala Leu Gly Val Ala Gly Leu Ile Val 50 55 60 acc cag ggg acc gat ctt tct gct ggt cgt cag gta ggg ctg gcg gca 240 Page 366 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Gln Gly Thr Asp Leu Ser Ala Gly Arg Gln Val Gly Leu Ala Ala 65 70 75 80 gtg gtg gct gcg aca tta ttg cag tcc atg gat aac gcc aac aaa gtg 288 Val Val Ala Ala Thr Leu Leu Gln Ser Met Asp Asn Ala Asn Lys Val 85 90 95 ttc ccg gaa atg gcg acg atg ccg att gcg ctg gtt att ctg att gtc 336 Phe Pro Glu Met Ala Thr Met Pro Ile Ala Leu Val Ile Leu Ile Val 100 105 110 tgt gcc att ggt gcg gtg atc ggt ttg atc aac ggt ctg att atc gct 384 Cys Ala Ile Gly Ala Val Ile Gly Leu Ile Asn Gly Leu Ile Ile Ala 115 120 125 tat ctc aac gtg acg ccg ttc att acc acg ctc ggc acg atg atc atc 432 Tyr Leu Asn Val Thr Pro Phe Ile Thr Thr Leu Gly Thr Met Ile Ile 130 135 140 gtc tat ggc atc aac tcg ctc tat tac gac ttt gtc ggg gcg tcg cca 480 Val Tyr Gly Ile Asn Ser Leu Tyr Tyr Asp Phe Val Gly Ala Ser Pro 145 150 155 160 att tct ggt ttt gac agt ggc ttc tct acc ttt gct cag ggc ttt gtc 528 Ile Ser Gly Phe Asp Ser Gly Phe Ser Thr Phe Ala Gln Gly Phe Val 165 170 175 gcg ctg ggg agt ttc cgt ctc tct tac atc acc ttc tac gcg ttg att 576 Ala Leu Gly Ser Phe Arg Leu Ser Tyr Ile Thr Phe Tyr Ala Leu Ile 180 185 190 gcg gtg gcg ttc gtc tgg gtg ttg tgg aac aaa acc cgc ttc ggt aag 624 Ala Val Ala Phe Val Trp Val Leu Trp Asn Lys Thr Arg Phe Gly Lys 195 200 205 aac att ttt gcc att ggc ggt aac ccg gaa gcg gca aaa gta tct ggt 672 Asn Ile Phe Ala Ile Gly Gly Asn Pro Glu Ala Ala Lys Val Ser Gly 210 215 220 gtc aac gtc ggc ctg aac ctg ctg atg atc tac gcg ttg tct ggc gtg 720 Val Asn Val Gly Leu Asn Leu Leu Met Ile Tyr Ala Leu Ser Gly Val 225 230 235 240 ttc tat gcc ttt ggc ggg atg tta gaa gcc gga cgt atc ggc tct gcc 768 Phe Tyr Ala Phe Gly Gly Met Leu Glu Ala Gly Arg Ile Gly Ser Ala 245 250 255 acc aac aac ctc ggc ttt atg tat gag ctg gat gct atc gcg gcg tgc 816 Thr Asn Asn Leu Gly Phe Met Tyr Glu Leu Asp Ala Ile Ala Ala Cys 260 265 270 gtg gta ggc ggt gta tcg ttc agc ggc ggt gtg ggg acg gtg att ggc 864 Val Val Gly Gly Val Ser Phe Ser Gly Gly Val Gly Thr Val Ile Gly 275 280 285 gtg gtg acc ggg gta att att ttt acc gtc atc aac tat ggc ctg acg 912 Val Val Thr Gly Val Ile Ile Phe Thr Val Ile Asn Tyr Gly Leu Thr 290 295 300 tat atc ggc gta aac cca tac tgg cag tac atc atc aaa ggg gcg att 960 Tyr Ile Gly Val Asn Pro Tyr Trp Gln Tyr Ile Ile Lys Gly Ala Ile 305 310 315 320 att atc ttc gcc gta gcg ctg gat tca ctg aaa tac gcg cgt aag aaa 1008 Ile Ile Phe Ala Val Ala Leu Asp Ser Leu Lys Tyr Ala Arg Lys Lys 325 330 335 tga 1011 Page 367 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 250 <211> 336 <212> PRT <213> Escherichia coli <400> 250 Met Ser Ala Leu Asn Lys Lys Ser Phe Leu Thr Tyr Leu Lys Glu Gly 1 5 10 15 Gly Ile Tyr Val Val Leu Leu Val Leu Leu Ala Ile Ile Ile Phe Gln 20 25 30 Asp Pro Thr Phe Leu Ser Leu Leu Asn Leu Ser Asn Ile Leu Thr Gln 35 40 45 Ser Ser Val Arg Ile Ile Ile Ala Leu Gly Val Ala Gly Leu Ile Val 50 55 60 Thr Gln Gly Thr Asp Leu Ser Ala Gly Arg Gln Val Gly Leu Ala Ala 65 70 75 80 Val Val Ala Ala Thr Leu Leu Gln Ser Met Asp Asn Ala Asn Lys Val 85 90 95 Phe Pro Glu Met Ala Thr Met Pro Ile Ala Leu Val Ile Leu Ile Val 100 105 110 Cys Ala Ile Gly Ala Val Ile Gly Leu Ile Asn Gly Leu Ile Ile Ala 115 120 125 Tyr Leu Asn Val Thr Pro Phe Ile Thr Thr Leu Gly Thr Met Ile Ile 130 135 140 Val Tyr Gly Ile Asn Ser Leu Tyr Tyr Asp Phe Val Gly Ala Ser Pro 145 150 155 160 Ile Ser Gly Phe Asp Ser Gly Phe Ser Thr Phe Ala Gln Gly Phe Val 165 170 175 Ala Leu Gly Ser Phe Arg Leu Ser Tyr Ile Thr Phe Tyr Ala Leu Ile 180 185 190 Ala Val Ala Phe Val Trp Val Leu Trp Asn Lys Thr Arg Phe Gly Lys 195 200 205 Asn Ile Phe Ala Ile Gly Gly Asn Pro Glu Ala Ala Lys Val Ser Gly 210 215 220 Val Asn Val Gly Leu Asn Leu Leu Met Ile Tyr Ala Leu Ser Gly Val 225 230 235 240 Page 368 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Tyr Ala Phe Gly Gly Met Leu Glu Ala Gly Arg Ile Gly Ser Ala 245 250 255 Thr Asn Asn Leu Gly Phe Met Tyr Glu Leu Asp Ala Ile Ala Ala Cys 260 265 270 Val Val Gly Gly Val Ser Phe Ser Gly Gly Val Gly Thr Val Ile Gly 275 280 285 Val Val Thr Gly Val Ile Ile Phe Thr Val Ile Asn Tyr Gly Leu Thr 290 295 300 Tyr Ile Gly Val Asn Pro Tyr Trp Gln Tyr Ile Ile Lys Gly Ala Ile 305 310 315 320 Ile Ile Phe Ala Val Ala Leu Asp Ser Leu Lys Tyr Ala Arg Lys Lys 325 330 335 <210> 251 <211> 1290 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(1290) <400> 251 atg gaa acg act caa acc agc acg att gcg tcg aaa gac tct cgt agt 48 Met Glu Thr Thr Gln Thr Ser Thr Ile Ala Ser Lys Asp Ser Arg Ser 1 5 10 15 gcc tgg cgc aag aca gac acc atg tgg atg ctg ggc ctt tac ggc acg 96 Ala Trp Arg Lys Thr Asp Thr Met Trp Met Leu Gly Leu Tyr Gly Thr 20 25 30 gca atc ggc gcg ggc gtg ctg ttc ctg cca atc aac gcc ggt gtt ggc 144 Ala Ile Gly Ala Gly Val Leu Phe Leu Pro Ile Asn Ala Gly Val Gly 35 40 45 ggt atg atc ccg ctg atc atc atg gct atc ctt gcg ttc ccg atg acg 192 Gly Met Ile Pro Leu Ile Ile Met Ala Ile Leu Ala Phe Pro Met Thr 50 55 60 ttt ttt gct cac cgc ggc ctg act cgc ttc gta ctg tct ggt aaa aac 240 Phe Phe Ala His Arg Gly Leu Thr Arg Phe Val Leu Ser Gly Lys Asn 65 70 75 80 ccg ggc gaa gac atc acc gag gtt gta gaa gaa cac ttt ggt att ggc 288 Pro Gly Glu Asp Ile Thr Glu Val Val Glu Glu His Phe Gly Ile Gly 85 90 95 gca ggt aaa ctg att acc ctg ctc tac ttc ttc gct atc tac ccg atc 336 Ala Gly Lys Leu Ile Thr Leu Leu Tyr Phe Phe Ala Ile Tyr Pro Ile 100 105 110 ctg ctg gtt tat agc gtg gca atc acc aat acc gtt gaa agc ttc atg 384 Leu Leu Val Tyr Ser Val Ala Ile Thr Asn Thr Val Glu Ser Phe Met 115 120 125 Page 369 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tct cac cag ctg ggt atg acg cca ccg ccg cgt gcg att ctg tcg ctg 432 Ser His Gln Leu Gly Met Thr Pro Pro Pro Arg Ala Ile Leu Ser Leu 130 135 140 atc ctg atc gtg ggt atg atg acc atc gtt cgc ttc ggt gag cag atg 480 Ile Leu Ile Val Gly Met Met Thr Ile Val Arg Phe Gly Glu Gln Met 145 150 155 160 atc gtt aaa gcg atg agt att ctg gta ttc ccg ttt gtt ggc gta ctg 528 Ile Val Lys Ala Met Ser Ile Leu Val Phe Pro Phe Val Gly Val Leu 165 170 175 atg ctg ctg gct ctg tac ctg atc ccg cag tgg aac ggc gct gca ctg 576 Met Leu Leu Ala Leu Tyr Leu Ile Pro Gln Trp Asn Gly Ala Ala Leu 180 185 190 gaa acg ctg tct ctg gac act gca tct gca acc gga aac ggt ctg tgg 624 Glu Thr Leu Ser Leu Asp Thr Ala Ser Ala Thr Gly Asn Gly Leu Trp 195 200 205 atg acc ctg tgg ctg gca att ccg gta atg gtg ttc tcg ttc aac cac 672 Met Thr Leu Trp Leu Ala Ile Pro Val Met Val Phe Ser Phe Asn His 210 215 220 tct ccg atc atc tct tct ttc gcc gtt gcg aag cgt gaa gag tac ggc 720 Ser Pro Ile Ile Ser Ser Phe Ala Val Ala Lys Arg Glu Glu Tyr Gly 225 230 235 240 gat atg gca gaa cag aaa tgc tcg aag atc ctg gca ttc gca cac atc 768 Asp Met Ala Glu Gln Lys Cys Ser Lys Ile Leu Ala Phe Ala His Ile 245 250 255 atg atg gtg ctg acc gta atg ttc ttc gtc ttc agc tgt gta ctg agc 816 Met Met Val Leu Thr Val Met Phe Phe Val Phe Ser Cys Val Leu Ser 260 265 270 ctg act ccg gca gac ctg gct gcg gct aaa gag cag aac atc tcg att 864 Leu Thr Pro Ala Asp Leu Ala Ala Ala Lys Glu Gln Asn Ile Ser Ile 275 280 285 ctg tct tac ctg gct aac cac ttt aac gca ccg gtt atc gcg tgg atg 912 Leu Ser Tyr Leu Ala Asn His Phe Asn Ala Pro Val Ile Ala Trp Met 290 295 300 gct ccg att atc gcg att atc gct atc acc aaa tcc ttc ctc ggt cac 960 Ala Pro Ile Ile Ala Ile Ile Ala Ile Thr Lys Ser Phe Leu Gly His 305 310 315 320 tac ctg ggc gca cgt gaa ggc ttc aac ggt atg gtg att aaa tct ctg 1008 Tyr Leu Gly Ala Arg Glu Gly Phe Asn Gly Met Val Ile Lys Ser Leu 325 330 335 cgt ggt aaa ggt aag tct atc gaa atc aac aag ctg aac cgt atc act 1056 Arg Gly Lys Gly Lys Ser Ile Glu Ile Asn Lys Leu Asn Arg Ile Thr 340 345 350 gcg ctg ttc atg ctg gta acg acc tgg att gtt gcc acc ctg aac ccg 1104 Ala Leu Phe Met Leu Val Thr Thr Trp Ile Val Ala Thr Leu Asn Pro 355 360 365 agc atc ctg ggt atg att gaa acc ctg ggc ggt cca atc atc gcg atg 1152 Ser Ile Leu Gly Met Ile Glu Thr Leu Gly Gly Pro Ile Ile Ala Met 370 375 380 atc ctg ttc ctg atg ccg atg tac gca att cag aaa gta ccg gca atg 1200 Ile Leu Phe Leu Met Pro Met Tyr Ala Ile Gln Lys Val Pro Ala Met 385 390 395 400 Page 370 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cgt aag tac agc ggt cac atc agc aac gta ttc gtt gtc gtg atg ggt 1248 Arg Lys Tyr Ser Gly His Ile Ser Asn Val Phe Val Val Val Met Gly 405 410 415 ctg att gca atc tcc gca atc ttc tac tct ctg ttc agc taa 1290 Leu Ile Ala Ile Ser Ala Ile Phe Tyr Ser Leu Phe Ser 420 425 <210> 252 <211> 429 <212> PRT <213> Escherichia coli <400> 252 Met Glu Thr Thr Gln Thr Ser Thr Ile Ala Ser Lys Asp Ser Arg Ser 1 5 10 15 Ala Trp Arg Lys Thr Asp Thr Met Trp Met Leu Gly Leu Tyr Gly Thr 20 25 30 Ala Ile Gly Ala Gly Val Leu Phe Leu Pro Ile Asn Ala Gly Val Gly 35 40 45 Gly Met Ile Pro Leu Ile Ile Met Ala Ile Leu Ala Phe Pro Met Thr 50 55 60 Phe Phe Ala His Arg Gly Leu Thr Arg Phe Val Leu Ser Gly Lys Asn 65 70 75 80 Pro Gly Glu Asp Ile Thr Glu Val Val Glu Glu His Phe Gly Ile Gly 85 90 95 Ala Gly Lys Leu Ile Thr Leu Leu Tyr Phe Phe Ala Ile Tyr Pro Ile 100 105 110 Leu Leu Val Tyr Ser Val Ala Ile Thr Asn Thr Val Glu Ser Phe Met 115 120 125 Ser His Gln Leu Gly Met Thr Pro Pro Pro Arg Ala Ile Leu Ser Leu 130 135 140 Ile Leu Ile Val Gly Met Met Thr Ile Val Arg Phe Gly Glu Gln Met 145 150 155 160 Ile Val Lys Ala Met Ser Ile Leu Val Phe Pro Phe Val Gly Val Leu 165 170 175 Met Leu Leu Ala Leu Tyr Leu Ile Pro Gln Trp Asn Gly Ala Ala Leu 180 185 190 Glu Thr Leu Ser Leu Asp Thr Ala Ser Ala Thr Gly Asn Gly Leu Trp 195 200 205 Page 371 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Thr Leu Trp Leu Ala Ile Pro Val Met Val Phe Ser Phe Asn His 210 215 220 Ser Pro Ile Ile Ser Ser Phe Ala Val Ala Lys Arg Glu Glu Tyr Gly 225 230 235 240 Asp Met Ala Glu Gln Lys Cys Ser Lys Ile Leu Ala Phe Ala His Ile 245 250 255 Met Met Val Leu Thr Val Met Phe Phe Val Phe Ser Cys Val Leu Ser 260 265 270 Leu Thr Pro Ala Asp Leu Ala Ala Ala Lys Glu Gln Asn Ile Ser Ile 275 280 285 Leu Ser Tyr Leu Ala Asn His Phe Asn Ala Pro Val Ile Ala Trp Met 290 295 300 Ala Pro Ile Ile Ala Ile Ile Ala Ile Thr Lys Ser Phe Leu Gly His 305 310 315 320 Tyr Leu Gly Ala Arg Glu Gly Phe Asn Gly Met Val Ile Lys Ser Leu 325 330 335 Arg Gly Lys Gly Lys Ser Ile Glu Ile Asn Lys Leu Asn Arg Ile Thr 340 345 350 Ala Leu Phe Met Leu Val Thr Thr Trp Ile Val Ala Thr Leu Asn Pro 355 360 365 Ser Ile Leu Gly Met Ile Glu Thr Leu Gly Gly Pro Ile Ile Ala Met 370 375 380 Ile Leu Phe Leu Met Pro Met Tyr Ala Ile Gln Lys Val Pro Ala Met 385 390 395 400 Arg Lys Tyr Ser Gly His Ile Ser Asn Val Phe Val Val Val Met Gly 405 410 415 Leu Ile Ala Ile Ser Ala Ile Phe Tyr Ser Leu Phe Ser 420 425 <210> 253 <211> 219 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(219) <400> 253 atg ttt cat tgt cct tta tgc cag cat gcc gca cat gcg cgt aca agc 48 Page 372 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Phe His Cys Pro Leu Cys Gln His Ala Ala His Ala Arg Thr Ser 1 5 10 15 cgc tat atc act gac acg aca aaa gag cgt tat cac cag tgt cag aac 96 Arg Tyr Ile Thr Asp Thr Thr Lys Glu Arg Tyr His Gln Cys Gln Asn 20 25 30 gtg aat tgc agc gcc acg ttc atc act tat gag tcg gta cag cga tac 144 Val Asn Cys Ser Ala Thr Phe Ile Thr Tyr Glu Ser Val Gln Arg Tyr 35 40 45 att gtg aag ccg gga gaa gtc cac gtc gta agg ccg cac ccg ttg ccg 192 Ile Val Lys Pro Gly Glu Val His Val Val Arg Pro His Pro Leu Pro 50 55 60 tca ggg cag caa att atg tgg atg taa 219 Ser Gly Gln Gln Ile Met Trp Met 65 70 <210> 254 <211> 72 <212> PRT <213> Escherichia coli <400> 254 Met Phe His Cys Pro Leu Cys Gln His Ala Ala His Ala Arg Thr Ser 1 5 10 15 Arg Tyr Ile Thr Asp Thr Thr Lys Glu Arg Tyr His Gln Cys Gln Asn 20 25 30 Val Asn Cys Ser Ala Thr Phe Ile Thr Tyr Glu Ser Val Gln Arg Tyr 35 40 45 Ile Val Lys Pro Gly Glu Val His Val Val Arg Pro His Pro Leu Pro 50 55 60 Ser Gly Gln Gln Ile Met Trp Met 65 70 <210> 255 <211> 2391 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(2391) <400> 255 atg gca att aac aat aca ggc tcg cga cga tta ctc gtc acg cta aca 48 Met Ala Ile Asn Asn Thr Gly Ser Arg Arg Leu Leu Val Thr Leu Thr 1 5 10 15 gcc ctt ttt gca gcg ctt tgc ggg ctg tat cta ctc att ggc gga ggc 96 Ala Leu Phe Ala Ala Leu Cys Gly Leu Tyr Leu Leu Ile Gly Gly Gly 20 25 30 tgg ctg gtc gcg att ggc ggc tcc tgg tac tac cct atc gct ggc ctt 144 Trp Leu Val Ala Ile Gly Gly Ser Trp Tyr Tyr Pro Ile Ala Gly Leu Page 373 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 35 40 45 gtg atg ctc ggc gtc gcc tgg atg ctg tgg cgc agt aaa cgc gcc gcg 192 Val Met Leu Gly Val Ala Trp Met Leu Trp Arg Ser Lys Arg Ala Ala 50 55 60 ctt tgg cta tac gca gcc ctg ctg ctc ggc acc atg att tgg ggc gtc 240 Leu Trp Leu Tyr Ala Ala Leu Leu Leu Gly Thr Met Ile Trp Gly Val 65 70 75 80 tgg gaa gtt ggt ttc gac ttc tgg gcg ctg act ccg cgc agc gac att 288 Trp Glu Val Gly Phe Asp Phe Trp Ala Leu Thr Pro Arg Ser Asp Ile 85 90 95 ctg gtc ttc ttc ggc atc tgg ctg atc ctg ccg ttt gtc tgg cgt cgc 336 Leu Val Phe Phe Gly Ile Trp Leu Ile Leu Pro Phe Val Trp Arg Arg 100 105 110 ctg gtc att cct gcc agc ggc gca gtt gcc gca ctg gtg gtc gca ctg 384 Leu Val Ile Pro Ala Ser Gly Ala Val Ala Ala Leu Val Val Ala Leu 115 120 125 ctg att agc ggt ggt atc ctg acc tgg gcc gga ttt aac gat ccg cag 432 Leu Ile Ser Gly Gly Ile Leu Thr Trp Ala Gly Phe Asn Asp Pro Gln 130 135 140 gag atc aac ggc acc tta agc gcc gat gcc aca cct gct gaa gct atc 480 Glu Ile Asn Gly Thr Leu Ser Ala Asp Ala Thr Pro Ala Glu Ala Ile 145 150 155 160 tcc ccc gta gcc gat cag gac tgg cct gcc tat ggt cgt aat cag gaa 528 Ser Pro Val Ala Asp Gln Asp Trp Pro Ala Tyr Gly Arg Asn Gln Glu 165 170 175 ggt caa cgc ttt tcg ccg ctg aaa caa att aac gcc gat aac gtc cat 576 Gly Gln Arg Phe Ser Pro Leu Lys Gln Ile Asn Ala Asp Asn Val His 180 185 190 aat ctg aaa gaa gcc tgg gtg ttc cgt act ggc gat gtg aag cag ccg 624 Asn Leu Lys Glu Ala Trp Val Phe Arg Thr Gly Asp Val Lys Gln Pro 195 200 205 aac gat ccg ggt gaa atc acc aat gaa gtg acg ccg att aaa gtg ggc 672 Asn Asp Pro Gly Glu Ile Thr Asn Glu Val Thr Pro Ile Lys Val Gly 210 215 220 gac acc ctt tac ctg tgt acc gct cac cag cgc ctg ttt gcg ctt gat 720 Asp Thr Leu Tyr Leu Cys Thr Ala His Gln Arg Leu Phe Ala Leu Asp 225 230 235 240 gcc gcc agc ggc aaa gag aaa tgg cat tac gat cct gag ctg aaa acc 768 Ala Ala Ser Gly Lys Glu Lys Trp His Tyr Asp Pro Glu Leu Lys Thr 245 250 255 aac gag tct ttc cag cac gta acc tgc cgt ggt gtc tct tat cat gaa 816 Asn Glu Ser Phe Gln His Val Thr Cys Arg Gly Val Ser Tyr His Glu 260 265 270 gcc aaa gca gaa acc gct tcg ccg gaa gtg atg gcg gat tgc ccg cgt 864 Ala Lys Ala Glu Thr Ala Ser Pro Glu Val Met Ala Asp Cys Pro Arg 275 280 285 cgt atc att ctt ccg gtc aat gat ggt cga ctg att gcg att aac gct 912 Arg Ile Ile Leu Pro Val Asn Asp Gly Arg Leu Ile Ala Ile Asn Ala 290 295 300 gaa aac ggc aaa ctg tgc gaa acc ttc gcc aat aaa ggc gtg ctc aat 960 Glu Asn Gly Lys Leu Cys Glu Thr Phe Ala Asn Lys Gly Val Leu Asn Page 374 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 305 310 315 320 ctg caa agc aat atg cca gac acc aaa ccg ggt ctg tat gaa ccg act 1008 Leu Gln Ser Asn Met Pro Asp Thr Lys Pro Gly Leu Tyr Glu Pro Thr 325 330 335 tcg cca ccg att atc acc gat aaa acc atc gtg atg gcc ggt tca gtt 1056 Ser Pro Pro Ile Ile Thr Asp Lys Thr Ile Val Met Ala Gly Ser Val 340 345 350 acc gat aac ttc tca acc cgc gaa acg tct ggc gtg atc cgt ggt ttt 1104 Thr Asp Asn Phe Ser Thr Arg Glu Thr Ser Gly Val Ile Arg Gly Phe 355 360 365 gat gtc aac acc ggg gag ctg ctg tgg gct ttt gat ccc ggc gcg aaa 1152 Asp Val Asn Thr Gly Glu Leu Leu Trp Ala Phe Asp Pro Gly Ala Lys 370 375 380 gat ccg aac gca atc ccg tct gac gaa cac acc ttt acc ttt aac tcg 1200 Asp Pro Asn Ala Ile Pro Ser Asp Glu His Thr Phe Thr Phe Asn Ser 385 390 395 400 cca aac tcc tgg gca cca gcg gcc tat gac gcg aag ctg gat ctg gtc 1248 Pro Asn Ser Trp Ala Pro Ala Ala Tyr Asp Ala Lys Leu Asp Leu Val 405 410 415 tat ctg ccg atg ggc gtg acc acg ccg gat atc tgg ggc ggt aac cgc 1296 Tyr Leu Pro Met Gly Val Thr Thr Pro Asp Ile Trp Gly Gly Asn Arg 420 425 430 aca ccg gaa cag gaa cgt tat gcc agc tcg att ctg gcg ctg aat gcc 1344 Thr Pro Glu Gln Glu Arg Tyr Ala Ser Ser Ile Leu Ala Leu Asn Ala 435 440 445 act acc ggg aaa ctg gcg tgg agc tac cag acc gtt cac cac gac ctg 1392 Thr Thr Gly Lys Leu Ala Trp Ser Tyr Gln Thr Val His His Asp Leu 450 455 460 tgg gac atg gat ctt ccg gca cag ccg acg ctg gcg gac atc acc gtt 1440 Trp Asp Met Asp Leu Pro Ala Gln Pro Thr Leu Ala Asp Ile Thr Val 465 470 475 480 aat ggt cag aaa gtg cca gtt att tac gct ccg gcg aaa acc ggc aac 1488 Asn Gly Gln Lys Val Pro Val Ile Tyr Ala Pro Ala Lys Thr Gly Asn 485 490 495 att ttt gtg ctc gat cgt cgt aat ggc gaa ctg gtg gtt ccg gca ccg 1536 Ile Phe Val Leu Asp Arg Arg Asn Gly Glu Leu Val Val Pro Ala Pro 500 505 510 gaa aaa ccg gtt ccc caa ggt gca gcg aaa ggc gat tac gta acc cca 1584 Glu Lys Pro Val Pro Gln Gly Ala Ala Lys Gly Asp Tyr Val Thr Pro 515 520 525 act caa ccg ttt tct gaa ctg agc ttc cgt ccg acg aaa gat ttg agc 1632 Thr Gln Pro Phe Ser Glu Leu Ser Phe Arg Pro Thr Lys Asp Leu Ser 530 535 540 ggt gcg gat atg tgg gga gcc acc atg ttt gac caa ctg gtg tgc cgc 1680 Gly Ala Asp Met Trp Gly Ala Thr Met Phe Asp Gln Leu Val Cys Arg 545 550 555 560 gtg atg ttc cac cag atg cgc tat gaa ggc att ttc acc ccg cca tct 1728 Val Met Phe His Gln Met Arg Tyr Glu Gly Ile Phe Thr Pro Pro Ser 565 570 575 gaa cag ggt acg ctg gtc ttc ccg ggt aac ctg ggg atg ttc gaa tgg 1776 Glu Gln Gly Thr Leu Val Phe Pro Gly Asn Leu Gly Met Phe Glu Trp Page 375 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 580 585 590 ggc ggg att tcc gtt gat cca aat cgt gaa gtg gcg att gcc aac cca 1824 Gly Gly Ile Ser Val Asp Pro Asn Arg Glu Val Ala Ile Ala Asn Pro 595 600 605 atg gca ctg ccg ttt gtt tcg aaa ctg atc ccg cgt ggt cct ggc aac 1872 Met Ala Leu Pro Phe Val Ser Lys Leu Ile Pro Arg Gly Pro Gly Asn 610 615 620 ccg atg gag cag ccg aaa gat gcc aaa ggc acg ggt acg gaa tcc ggc 1920 Pro Met Glu Gln Pro Lys Asp Ala Lys Gly Thr Gly Thr Glu Ser Gly 625 630 635 640 att cag cca cag tac ggt gta ccg tat ggt gtc acg ctc aac ccg ttc 1968 Ile Gln Pro Gln Tyr Gly Val Pro Tyr Gly Val Thr Leu Asn Pro Phe 645 650 655 ctc tca cca ttt ggt ctg cca tgt aaa cag cca gca tgg ggt tat atc 2016 Leu Ser Pro Phe Gly Leu Pro Cys Lys Gln Pro Ala Trp Gly Tyr Ile 660 665 670 tcg gcg ctg gat ctg aaa act aat gaa gtg gtg tgg aag aaa cgt att 2064 Ser Ala Leu Asp Leu Lys Thr Asn Glu Val Val Trp Lys Lys Arg Ile 675 680 685 ggt acg ccg cag gac agt atg ccg ttc ccg atg ccg gtt ccg gtg ccg 2112 Gly Thr Pro Gln Asp Ser Met Pro Phe Pro Met Pro Val Pro Val Pro 690 695 700 ttc aat atg ggt atg ccg atg ctg ggc ggg cca atc tcc acg gcg ggt 2160 Phe Asn Met Gly Met Pro Met Leu Gly Gly Pro Ile Ser Thr Ala Gly 705 710 715 720 aac gtg ctg ttt atc gcc gct acg gca gat aac tac ctg cgc gct tac 2208 Asn Val Leu Phe Ile Ala Ala Thr Ala Asp Asn Tyr Leu Arg Ala Tyr 725 730 735 aac atg agc aac ggt gaa aaa ctg tgg cag ggt cgt tta cca gcg ggt 2256 Asn Met Ser Asn Gly Glu Lys Leu Trp Gln Gly Arg Leu Pro Ala Gly 740 745 750 ggt cag gct acg cca atg acc tat gaa gtg aat ggt aag cag tat gtg 2304 Gly Gln Ala Thr Pro Met Thr Tyr Glu Val Asn Gly Lys Gln Tyr Val 755 760 765 gtg atc tcc gca ggc ggt cac ggt tca ttt ggt acg aag atg ggc gac 2352 Val Ile Ser Ala Gly Gly His Gly Ser Phe Gly Thr Lys Met Gly Asp 770 775 780 tat att gtg gct tat gcg ctg ccg gat gat gtg aag taa 2391 Tyr Ile Val Ala Tyr Ala Leu Pro Asp Asp Val Lys 785 790 795 <210> 256 <211> 796 <212> PRT <213> Escherichia coli <400> 256 Met Ala Ile Asn Asn Thr Gly Ser Arg Arg Leu Leu Val Thr Leu Thr 1 5 10 15 Ala Leu Phe Ala Ala Leu Cys Gly Leu Tyr Leu Leu Ile Gly Gly Gly 20 25 30 Page 376 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Trp Leu Val Ala Ile Gly Gly Ser Trp Tyr Tyr Pro Ile Ala Gly Leu 35 40 45 Val Met Leu Gly Val Ala Trp Met Leu Trp Arg Ser Lys Arg Ala Ala 50 55 60 Leu Trp Leu Tyr Ala Ala Leu Leu Leu Gly Thr Met Ile Trp Gly Val 65 70 75 80 Trp Glu Val Gly Phe Asp Phe Trp Ala Leu Thr Pro Arg Ser Asp Ile 85 90 95 Leu Val Phe Phe Gly Ile Trp Leu Ile Leu Pro Phe Val Trp Arg Arg 100 105 110 Leu Val Ile Pro Ala Ser Gly Ala Val Ala Ala Leu Val Val Ala Leu 115 120 125 Leu Ile Ser Gly Gly Ile Leu Thr Trp Ala Gly Phe Asn Asp Pro Gln 130 135 140 Glu Ile Asn Gly Thr Leu Ser Ala Asp Ala Thr Pro Ala Glu Ala Ile 145 150 155 160 Ser Pro Val Ala Asp Gln Asp Trp Pro Ala Tyr Gly Arg Asn Gln Glu 165 170 175 Gly Gln Arg Phe Ser Pro Leu Lys Gln Ile Asn Ala Asp Asn Val His 180 185 190 Asn Leu Lys Glu Ala Trp Val Phe Arg Thr Gly Asp Val Lys Gln Pro 195 200 205 Asn Asp Pro Gly Glu Ile Thr Asn Glu Val Thr Pro Ile Lys Val Gly 210 215 220 Asp Thr Leu Tyr Leu Cys Thr Ala His Gln Arg Leu Phe Ala Leu Asp 225 230 235 240 Ala Ala Ser Gly Lys Glu Lys Trp His Tyr Asp Pro Glu Leu Lys Thr 245 250 255 Asn Glu Ser Phe Gln His Val Thr Cys Arg Gly Val Ser Tyr His Glu 260 265 270 Ala Lys Ala Glu Thr Ala Ser Pro Glu Val Met Ala Asp Cys Pro Arg 275 280 285 Arg Ile Ile Leu Pro Val Asn Asp Gly Arg Leu Ile Ala Ile Asn Ala 290 295 300 Page 377 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Asn Gly Lys Leu Cys Glu Thr Phe Ala Asn Lys Gly Val Leu Asn 305 310 315 320 Leu Gln Ser Asn Met Pro Asp Thr Lys Pro Gly Leu Tyr Glu Pro Thr 325 330 335 Ser Pro Pro Ile Ile Thr Asp Lys Thr Ile Val Met Ala Gly Ser Val 340 345 350 Thr Asp Asn Phe Ser Thr Arg Glu Thr Ser Gly Val Ile Arg Gly Phe 355 360 365 Asp Val Asn Thr Gly Glu Leu Leu Trp Ala Phe Asp Pro Gly Ala Lys 370 375 380 Asp Pro Asn Ala Ile Pro Ser Asp Glu His Thr Phe Thr Phe Asn Ser 385 390 395 400 Pro Asn Ser Trp Ala Pro Ala Ala Tyr Asp Ala Lys Leu Asp Leu Val 405 410 415 Tyr Leu Pro Met Gly Val Thr Thr Pro Asp Ile Trp Gly Gly Asn Arg 420 425 430 Thr Pro Glu Gln Glu Arg Tyr Ala Ser Ser Ile Leu Ala Leu Asn Ala 435 440 445 Thr Thr Gly Lys Leu Ala Trp Ser Tyr Gln Thr Val His His Asp Leu 450 455 460 Trp Asp Met Asp Leu Pro Ala Gln Pro Thr Leu Ala Asp Ile Thr Val 465 470 475 480 Asn Gly Gln Lys Val Pro Val Ile Tyr Ala Pro Ala Lys Thr Gly Asn 485 490 495 Ile Phe Val Leu Asp Arg Arg Asn Gly Glu Leu Val Val Pro Ala Pro 500 505 510 Glu Lys Pro Val Pro Gln Gly Ala Ala Lys Gly Asp Tyr Val Thr Pro 515 520 525 Thr Gln Pro Phe Ser Glu Leu Ser Phe Arg Pro Thr Lys Asp Leu Ser 530 535 540 Gly Ala Asp Met Trp Gly Ala Thr Met Phe Asp Gln Leu Val Cys Arg 545 550 555 560 Val Met Phe His Gln Met Arg Tyr Glu Gly Ile Phe Thr Pro Pro Ser 565 570 575 Page 378 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Gln Gly Thr Leu Val Phe Pro Gly Asn Leu Gly Met Phe Glu Trp 580 585 590 Gly Gly Ile Ser Val Asp Pro Asn Arg Glu Val Ala Ile Ala Asn Pro 595 600 605 Met Ala Leu Pro Phe Val Ser Lys Leu Ile Pro Arg Gly Pro Gly Asn 610 615 620 Pro Met Glu Gln Pro Lys Asp Ala Lys Gly Thr Gly Thr Glu Ser Gly 625 630 635 640 Ile Gln Pro Gln Tyr Gly Val Pro Tyr Gly Val Thr Leu Asn Pro Phe 645 650 655 Leu Ser Pro Phe Gly Leu Pro Cys Lys Gln Pro Ala Trp Gly Tyr Ile 660 665 670 Ser Ala Leu Asp Leu Lys Thr Asn Glu Val Val Trp Lys Lys Arg Ile 675 680 685 Gly Thr Pro Gln Asp Ser Met Pro Phe Pro Met Pro Val Pro Val Pro 690 695 700 Phe Asn Met Gly Met Pro Met Leu Gly Gly Pro Ile Ser Thr Ala Gly 705 710 715 720 Asn Val Leu Phe Ile Ala Ala Thr Ala Asp Asn Tyr Leu Arg Ala Tyr 725 730 735 Asn Met Ser Asn Gly Glu Lys Leu Trp Gln Gly Arg Leu Pro Ala Gly 740 745 750 Gly Gln Ala Thr Pro Met Thr Tyr Glu Val Asn Gly Lys Gln Tyr Val 755 760 765 Val Ile Ser Ala Gly Gly His Gly Ser Phe Gly Thr Lys Met Gly Asp 770 775 780 Tyr Ile Val Ala Tyr Ala Leu Pro Asp Asp Val Lys 785 790 795 <210> 257 <211> 1332 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(1332) Page 379 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 257 atg agt act tca gat agc att gta tcc agc cag aca aaa caa tcg tcc 48 Met Ser Thr Ser Asp Ser Ile Val Ser Ser Gln Thr Lys Gln Ser Ser 1 5 10 15 tgg cgt aaa tca gat acc aca tgg acg tta ggc ttg ttt ggt acg gca 96 Trp Arg Lys Ser Asp Thr Thr Trp Thr Leu Gly Leu Phe Gly Thr Ala 20 25 30 atc ggc gcc ggg gtg ctg ttc ttc cct atc cgc gca ggt ttt ggc gga 144 Ile Gly Ala Gly Val Leu Phe Phe Pro Ile Arg Ala Gly Phe Gly Gly 35 40 45 ctg atc ccg att ctt ctg atg ttg gta ttg gca tac ccc atc gcg ttt 192 Leu Ile Pro Ile Leu Leu Met Leu Val Leu Ala Tyr Pro Ile Ala Phe 50 55 60 tat tgc cac cgg gcg ctg gcg cgt ctg tgt ctt tct ggc tct aac cct 240 Tyr Cys His Arg Ala Leu Ala Arg Leu Cys Leu Ser Gly Ser Asn Pro 65 70 75 80 tcc ggc aac att acg gaa acg gtg gaa gag cat ttt ggt aaa act ggc 288 Ser Gly Asn Ile Thr Glu Thr Val Glu Glu His Phe Gly Lys Thr Gly 85 90 95 ggc gtg gtt atc acg ttc ctg tac ttc ttc gcg att tgc cca ctg ctg 336 Gly Val Val Ile Thr Phe Leu Tyr Phe Phe Ala Ile Cys Pro Leu Leu 100 105 110 tgg att tat ggc gtt act att acc aat acc ttt atg acg ttc tgg gaa 384 Trp Ile Tyr Gly Val Thr Ile Thr Asn Thr Phe Met Thr Phe Trp Glu 115 120 125 aac cag ctc ggc ttt gca ccg ctg aat cgc ggc ttt gtg gcg ctg ttc 432 Asn Gln Leu Gly Phe Ala Pro Leu Asn Arg Gly Phe Val Ala Leu Phe 130 135 140 ctg ttg ctg ctg atg gct ttc gtc atc tgg ttt ggt aag gat ctg atg 480 Leu Leu Leu Leu Met Ala Phe Val Ile Trp Phe Gly Lys Asp Leu Met 145 150 155 160 gtt aaa gtg atg agc tac ctg gta tgg ccg ttt atc gcc agc ctg gtg 528 Val Lys Val Met Ser Tyr Leu Val Trp Pro Phe Ile Ala Ser Leu Val 165 170 175 ctg att tct ttg tcg ctg atc cct tac tgg aac tct gca gtt atc gac 576 Leu Ile Ser Leu Ser Leu Ile Pro Tyr Trp Asn Ser Ala Val Ile Asp 180 185 190 cag gtt gac ctc ggt tcg ctg tcg tta acc ggt cat gac ggt atc ctg 624 Gln Val Asp Leu Gly Ser Leu Ser Leu Thr Gly His Asp Gly Ile Leu 195 200 205 atc act gtc tgg ctg ggg att tcc atc atg gtt ttc tcc ttt aac ttc 672 Ile Thr Val Trp Leu Gly Ile Ser Ile Met Val Phe Ser Phe Asn Phe 210 215 220 tcg cca atc gtc tct tcc ttc gtg gtt tct aag cgt gaa gag tat gag 720 Ser Pro Ile Val Ser Ser Phe Val Val Ser Lys Arg Glu Glu Tyr Glu 225 230 235 240 aaa gac ttc ggt cgc gac ttc acc gaa cgt aaa tgt tcc caa atc att 768 Lys Asp Phe Gly Arg Asp Phe Thr Glu Arg Lys Cys Ser Gln Ile Ile 245 250 255 tct cgt gcc agc atg ctg atg gtt gca gtg gtg atg ttc ttt gcc ttt 816 Ser Arg Ala Ser Met Leu Met Val Ala Val Val Met Phe Phe Ala Phe 260 265 270 Page 380 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt agc tgc ctg ttt act ctg tct ccg gcc aac atg gcg gaa gcc aaa gcg 864 Ser Cys Leu Phe Thr Leu Ser Pro Ala Asn Met Ala Glu Ala Lys Ala 275 280 285 cag aat att cca gtg ctt tct tat ctg gct aac cac ttt gcg tcc atg 912 Gln Asn Ile Pro Val Leu Ser Tyr Leu Ala Asn His Phe Ala Ser Met 290 295 300 acc ggt acc aaa aca acg ttc gcg att aca ctg gaa tat gcg gct tcc 960 Thr Gly Thr Lys Thr Thr Phe Ala Ile Thr Leu Glu Tyr Ala Ala Ser 305 310 315 320 atc atc gca ctc gtg gct atc ttc aaa tct ttc ttc ggt cac tat ctg 1008 Ile Ile Ala Leu Val Ala Ile Phe Lys Ser Phe Phe Gly His Tyr Leu 325 330 335 gga acg ctg gaa ggt ctg aat ggc ctg gtc ctg aag ttt ggt tat aaa 1056 Gly Thr Leu Glu Gly Leu Asn Gly Leu Val Leu Lys Phe Gly Tyr Lys 340 345 350 ggc gac aaa act aaa gtg tcg ctg ggt aaa ctg aac act atc agc atg 1104 Gly Asp Lys Thr Lys Val Ser Leu Gly Lys Leu Asn Thr Ile Ser Met 355 360 365 atc ttc atc atg ggc tcc acc tgg gtt gtt gcc tac gcc aac ccg aac 1152 Ile Phe Ile Met Gly Ser Thr Trp Val Val Ala Tyr Ala Asn Pro Asn 370 375 380 atc ctt gac ctg att gaa gcc atg ggc gca ccg att atc gca tcc ctg 1200 Ile Leu Asp Leu Ile Glu Ala Met Gly Ala Pro Ile Ile Ala Ser Leu 385 390 395 400 ctg tgc ctg ttg ccg atg tat gcc atc cgt aaa gcg ccg tct ctg gcg 1248 Leu Cys Leu Leu Pro Met Tyr Ala Ile Arg Lys Ala Pro Ser Leu Ala 405 410 415 aaa tac cgt ggt cgt ctg gat aac gtg ttt gtt acc gtg att ggt ctg 1296 Lys Tyr Arg Gly Arg Leu Asp Asn Val Phe Val Thr Val Ile Gly Leu 420 425 430 ctg acc atc ctg aac atc gta tac aaa ctg ttt taa 1332 Leu Thr Ile Leu Asn Ile Val Tyr Lys Leu Phe 435 440 <210> 258 <211> 443 <212> PRT <213> Escherichia coli <400> 258 Met Ser Thr Ser Asp Ser Ile Val Ser Ser Gln Thr Lys Gln Ser Ser 1 5 10 15 Trp Arg Lys Ser Asp Thr Thr Trp Thr Leu Gly Leu Phe Gly Thr Ala 20 25 30 Ile Gly Ala Gly Val Leu Phe Phe Pro Ile Arg Ala Gly Phe Gly Gly 35 40 45 Leu Ile Pro Ile Leu Leu Met Leu Val Leu Ala Tyr Pro Ile Ala Phe 50 55 60 Page 381 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Tyr Cys His Arg Ala Leu Ala Arg Leu Cys Leu Ser Gly Ser Asn Pro 65 70 75 80 Ser Gly Asn Ile Thr Glu Thr Val Glu Glu His Phe Gly Lys Thr Gly 85 90 95 Gly Val Val Ile Thr Phe Leu Tyr Phe Phe Ala Ile Cys Pro Leu Leu 100 105 110 Trp Ile Tyr Gly Val Thr Ile Thr Asn Thr Phe Met Thr Phe Trp Glu 115 120 125 Asn Gln Leu Gly Phe Ala Pro Leu Asn Arg Gly Phe Val Ala Leu Phe 130 135 140 Leu Leu Leu Leu Met Ala Phe Val Ile Trp Phe Gly Lys Asp Leu Met 145 150 155 160 Val Lys Val Met Ser Tyr Leu Val Trp Pro Phe Ile Ala Ser Leu Val 165 170 175 Leu Ile Ser Leu Ser Leu Ile Pro Tyr Trp Asn Ser Ala Val Ile Asp 180 185 190 Gln Val Asp Leu Gly Ser Leu Ser Leu Thr Gly His Asp Gly Ile Leu 195 200 205 Ile Thr Val Trp Leu Gly Ile Ser Ile Met Val Phe Ser Phe Asn Phe 210 215 220 Ser Pro Ile Val Ser Ser Phe Val Val Ser Lys Arg Glu Glu Tyr Glu 225 230 235 240 Lys Asp Phe Gly Arg Asp Phe Thr Glu Arg Lys Cys Ser Gln Ile Ile 245 250 255 Ser Arg Ala Ser Met Leu Met Val Ala Val Val Met Phe Phe Ala Phe 260 265 270 Ser Cys Leu Phe Thr Leu Ser Pro Ala Asn Met Ala Glu Ala Lys Ala 275 280 285 Gln Asn Ile Pro Val Leu Ser Tyr Leu Ala Asn His Phe Ala Ser Met 290 295 300 Thr Gly Thr Lys Thr Thr Phe Ala Ile Thr Leu Glu Tyr Ala Ala Ser 305 310 315 320 Ile Ile Ala Leu Val Ala Ile Phe Lys Ser Phe Phe Gly His Tyr Leu 325 330 335 Page 382 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Thr Leu Glu Gly Leu Asn Gly Leu Val Leu Lys Phe Gly Tyr Lys 340 345 350 Gly Asp Lys Thr Lys Val Ser Leu Gly Lys Leu Asn Thr Ile Ser Met 355 360 365 Ile Phe Ile Met Gly Ser Thr Trp Val Val Ala Tyr Ala Asn Pro Asn 370 375 380 Ile Leu Asp Leu Ile Glu Ala Met Gly Ala Pro Ile Ile Ala Ser Leu 385 390 395 400 Leu Cys Leu Leu Pro Met Tyr Ala Ile Arg Lys Ala Pro Ser Leu Ala 405 410 415 Lys Tyr Arg Gly Arg Leu Asp Asn Val Phe Val Thr Val Ile Gly Leu 420 425 430 Leu Thr Ile Leu Asn Ile Val Tyr Lys Leu Phe 435 440 <210> 259 <211> 2049 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(2049) <400> 259 atg aac atg ttt ttt agg ctt acc gcg tta gct ggc ctg ctt gca ata 48 Met Asn Met Phe Phe Arg Leu Thr Ala Leu Ala Gly Leu Leu Ala Ile 1 5 10 15 gca ggc cag acc ttc gct gta gaa gat atc acg cgt gct gat caa att 96 Ala Gly Gln Thr Phe Ala Val Glu Asp Ile Thr Arg Ala Asp Gln Ile 20 25 30 ccg gta tta aag gaa gag acg cag cat gcg acg gta agt gag cgc gta 144 Pro Val Leu Lys Glu Glu Thr Gln His Ala Thr Val Ser Glu Arg Val 35 40 45 acg tcg cgc ttc acc cgt tct cat tat cgc cag ttc gac ctc gat cag 192 Thr Ser Arg Phe Thr Arg Ser His Tyr Arg Gln Phe Asp Leu Asp Gln 50 55 60 gca ttt tcg gcc aaa atc ttt gac cgc tac ctg aat ctg ctc gat tac 240 Ala Phe Ser Ala Lys Ile Phe Asp Arg Tyr Leu Asn Leu Leu Asp Tyr 65 70 75 80 agc cac aac gtg ctg ctg gca agc gat gtt gaa cag ttc gcg aaa aag 288 Ser His Asn Val Leu Leu Ala Ser Asp Val Glu Gln Phe Ala Lys Lys 85 90 95 aaa acc gag tta ggc gat gaa ctg cgt tca ggc aaa ctc gac gtt ttc 336 Lys Thr Glu Leu Gly Asp Glu Leu Arg Ser Gly Lys Leu Asp Val Phe 100 105 110 Page 383 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tac gat ctc tac aat ctg gcg caa aag cgc cgt ttt gag cgt tac cag 384 Tyr Asp Leu Tyr Asn Leu Ala Gln Lys Arg Arg Phe Glu Arg Tyr Gln 115 120 125 tac gct ttg tcg gta ctg gaa aag ccg atg gat ttc acc ggc aac gac 432 Tyr Ala Leu Ser Val Leu Glu Lys Pro Met Asp Phe Thr Gly Asn Asp 130 135 140 act tat aac ctt gac cgc agc aaa gcg ccc tgg ccg aaa aac gag gct 480 Thr Tyr Asn Leu Asp Arg Ser Lys Ala Pro Trp Pro Lys Asn Glu Ala 145 150 155 160 gag ttg aac gcg ctg tgg gac agt aaa gtc aaa ttc gac gag tta agc 528 Glu Leu Asn Ala Leu Trp Asp Ser Lys Val Lys Phe Asp Glu Leu Ser 165 170 175 ctg aag ctg aca gga aaa acg gat aaa gaa att cgt gaa acc ctg act 576 Leu Lys Leu Thr Gly Lys Thr Asp Lys Glu Ile Arg Glu Thr Leu Thr 180 185 190 cgc cgc tac aaa ttt gcc att cgt cgt ctg gcg caa acc aac agc gaa 624 Arg Arg Tyr Lys Phe Ala Ile Arg Arg Leu Ala Gln Thr Asn Ser Glu 195 200 205 gat gtt ttc tcg ctg gca atg acg gcg ttt gcg cgt gaa atc gac ccg 672 Asp Val Phe Ser Leu Ala Met Thr Ala Phe Ala Arg Glu Ile Asp Pro 210 215 220 cat acc aac tat ctt tcc ccg cgt aat acc gaa cag ttc aac act gaa 720 His Thr Asn Tyr Leu Ser Pro Arg Asn Thr Glu Gln Phe Asn Thr Glu 225 230 235 240 atg agt ttg tcg ctg gaa ggt att ggc gca gtg ctg caa atg gat gat 768 Met Ser Leu Ser Leu Glu Gly Ile Gly Ala Val Leu Gln Met Asp Asp 245 250 255 gac tac acc gtt atc aat tcg atg gtg gca ggt ggt ccg gca gcg aag 816 Asp Tyr Thr Val Ile Asn Ser Met Val Ala Gly Gly Pro Ala Ala Lys 260 265 270 agt aaa gct atc agc gtt ggt gac aaa att gtc ggt gtt ggt caa aca 864 Ser Lys Ala Ile Ser Val Gly Asp Lys Ile Val Gly Val Gly Gln Thr 275 280 285 ggc aag ccg atg gtt gac gtg att ggc tgg cgt ctt gat gat gtg gtt 912 Gly Lys Pro Met Val Asp Val Ile Gly Trp Arg Leu Asp Asp Val Val 290 295 300 gcc tta att aaa ggg ccg aag ggc agt aaa gtt cgt ctg gaa att tta 960 Ala Leu Ile Lys Gly Pro Lys Gly Ser Lys Val Arg Leu Glu Ile Leu 305 310 315 320 cct gct ggt aaa ggg acc aag acc cgt act gta acg ttg acc cgt gaa 1008 Pro Ala Gly Lys Gly Thr Lys Thr Arg Thr Val Thr Leu Thr Arg Glu 325 330 335 cgt att cgt ctc gaa gac cgc gcg gtt aaa atg tcg gtg aag acc gtc 1056 Arg Ile Arg Leu Glu Asp Arg Ala Val Lys Met Ser Val Lys Thr Val 340 345 350 ggt aaa gag aaa gtc ggc gtg ctg gat att ccg ggc ttc tat gtg ggt 1104 Gly Lys Glu Lys Val Gly Val Leu Asp Ile Pro Gly Phe Tyr Val Gly 355 360 365 ttg aca gac gat gtc aaa gtg caa ctg cag aaa ctg gaa aaa cag aat 1152 Leu Thr Asp Asp Val Lys Val Gln Leu Gln Lys Leu Glu Lys Gln Asn 370 375 380 Page 384 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gtc agc agc gtc atc atc gac ctg cgt agc aat ggc ggt ggg gcg tta 1200 Val Ser Ser Val Ile Ile Asp Leu Arg Ser Asn Gly Gly Gly Ala Leu 385 390 395 400 act gaa gcc gta tcg ctc tcc ggt ctg ttt att cct gcg ggt ccc att 1248 Thr Glu Ala Val Ser Leu Ser Gly Leu Phe Ile Pro Ala Gly Pro Ile 405 410 415 gtt cag gtc cgc gat aac aac ggc aag gtt cgt gaa gat agc gat acc 1296 Val Gln Val Arg Asp Asn Asn Gly Lys Val Arg Glu Asp Ser Asp Thr 420 425 430 gac gga cag gtt ttc tat aaa ggc ccg ctg gtg gtg ctg gtt gac cgc 1344 Asp Gly Gln Val Phe Tyr Lys Gly Pro Leu Val Val Leu Val Asp Arg 435 440 445 ttc agt gct tcg gct tca gaa atc ttt gcc gcg gca atg cag gat tac 1392 Phe Ser Ala Ser Ala Ser Glu Ile Phe Ala Ala Ala Met Gln Asp Tyr 450 455 460 ggt cgt gcg ctg gtt gtg ggt gaa ccg acg ttt ggt aaa ggc acc gtt 1440 Gly Arg Ala Leu Val Val Gly Glu Pro Thr Phe Gly Lys Gly Thr Val 465 470 475 480 cag caa tac cgt tca ttg aac cgt att tac gat cag atg tta cgt cct 1488 Gln Gln Tyr Arg Ser Leu Asn Arg Ile Tyr Asp Gln Met Leu Arg Pro 485 490 495 gaa tgg cca gcg ctg ggt tct gtg cag tac acg atc cag aaa ttc tat 1536 Glu Trp Pro Ala Leu Gly Ser Val Gln Tyr Thr Ile Gln Lys Phe Tyr 500 505 510 cgc gtt aac ggc ggc agt acg caa cgt aaa ggc gta acg cca gac atc 1584 Arg Val Asn Gly Gly Ser Thr Gln Arg Lys Gly Val Thr Pro Asp Ile 515 520 525 atc atg ccg acg ggt aat gaa gaa acg gaa acg ggt gag aaa ttc gaa 1632 Ile Met Pro Thr Gly Asn Glu Glu Thr Glu Thr Gly Glu Lys Phe Glu 530 535 540 gat aac gcg ctg ccg tgg gat agc att gat gcc gcg act tat gtg aaa 1680 Asp Asn Ala Leu Pro Trp Asp Ser Ile Asp Ala Ala Thr Tyr Val Lys 545 550 555 560 tca gga gat tta acg gcc ttt gaa ccg gag ctg ctg aag gaa cat aat 1728 Ser Gly Asp Leu Thr Ala Phe Glu Pro Glu Leu Leu Lys Glu His Asn 565 570 575 gcg cgt atc gcg aaa gat cct gag ttc cag aac atc atg aag gat atc 1776 Ala Arg Ile Ala Lys Asp Pro Glu Phe Gln Asn Ile Met Lys Asp Ile 580 585 590 gcg cgc ttc aac gct atg aag gac aag cgc aat atc gtt tct ctg aat 1824 Ala Arg Phe Asn Ala Met Lys Asp Lys Arg Asn Ile Val Ser Leu Asn 595 600 605 tac gct gtg cgt gag aaa gag aat aat gaa gat gat gcg acg cgt ctg 1872 Tyr Ala Val Arg Glu Lys Glu Asn Asn Glu Asp Asp Ala Thr Arg Leu 610 615 620 gcg cgt ttg aac gaa cgc ttt aaa cgc gaa ggt aaa ccg gag ttg aag 1920 Ala Arg Leu Asn Glu Arg Phe Lys Arg Glu Gly Lys Pro Glu Leu Lys 625 630 635 640 aaa ctg gat gat cta ccg aaa gat tac cag gag ccg gat cct tat ctg 1968 Lys Leu Asp Asp Leu Pro Lys Asp Tyr Gln Glu Pro Asp Pro Tyr Leu 645 650 655 Page 385 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gat gag acg gtg aat atc gca ctc gat ctg gcg aag ctt gaa aaa gcc 2016 Asp Glu Thr Val Asn Ile Ala Leu Asp Leu Ala Lys Leu Glu Lys Ala 660 665 670 aga ccc gcg gaa caa ccc gct ccc gtc aag taa 2049 Arg Pro Ala Glu Gln Pro Ala Pro Val Lys 675 680 <210> 260 <211> 682 <212> PRT <213> Escherichia coli <400> 260 Met Asn Met Phe Phe Arg Leu Thr Ala Leu Ala Gly Leu Leu Ala Ile 1 5 10 15 Ala Gly Gln Thr Phe Ala Val Glu Asp Ile Thr Arg Ala Asp Gln Ile 20 25 30 Pro Val Leu Lys Glu Glu Thr Gln His Ala Thr Val Ser Glu Arg Val 35 40 45 Thr Ser Arg Phe Thr Arg Ser His Tyr Arg Gln Phe Asp Leu Asp Gln 50 55 60 Ala Phe Ser Ala Lys Ile Phe Asp Arg Tyr Leu Asn Leu Leu Asp Tyr 65 70 75 80 Ser His Asn Val Leu Leu Ala Ser Asp Val Glu Gln Phe Ala Lys Lys 85 90 95 Lys Thr Glu Leu Gly Asp Glu Leu Arg Ser Gly Lys Leu Asp Val Phe 100 105 110 Tyr Asp Leu Tyr Asn Leu Ala Gln Lys Arg Arg Phe Glu Arg Tyr Gln 115 120 125 Tyr Ala Leu Ser Val Leu Glu Lys Pro Met Asp Phe Thr Gly Asn Asp 130 135 140 Thr Tyr Asn Leu Asp Arg Ser Lys Ala Pro Trp Pro Lys Asn Glu Ala 145 150 155 160 Glu Leu Asn Ala Leu Trp Asp Ser Lys Val Lys Phe Asp Glu Leu Ser 165 170 175 Leu Lys Leu Thr Gly Lys Thr Asp Lys Glu Ile Arg Glu Thr Leu Thr 180 185 190 Arg Arg Tyr Lys Phe Ala Ile Arg Arg Leu Ala Gln Thr Asn Ser Glu 195 200 205 Page 386 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Val Phe Ser Leu Ala Met Thr Ala Phe Ala Arg Glu Ile Asp Pro 210 215 220 His Thr Asn Tyr Leu Ser Pro Arg Asn Thr Glu Gln Phe Asn Thr Glu 225 230 235 240 Met Ser Leu Ser Leu Glu Gly Ile Gly Ala Val Leu Gln Met Asp Asp 245 250 255 Asp Tyr Thr Val Ile Asn Ser Met Val Ala Gly Gly Pro Ala Ala Lys 260 265 270 Ser Lys Ala Ile Ser Val Gly Asp Lys Ile Val Gly Val Gly Gln Thr 275 280 285 Gly Lys Pro Met Val Asp Val Ile Gly Trp Arg Leu Asp Asp Val Val 290 295 300 Ala Leu Ile Lys Gly Pro Lys Gly Ser Lys Val Arg Leu Glu Ile Leu 305 310 315 320 Pro Ala Gly Lys Gly Thr Lys Thr Arg Thr Val Thr Leu Thr Arg Glu 325 330 335 Arg Ile Arg Leu Glu Asp Arg Ala Val Lys Met Ser Val Lys Thr Val 340 345 350 Gly Lys Glu Lys Val Gly Val Leu Asp Ile Pro Gly Phe Tyr Val Gly 355 360 365 Leu Thr Asp Asp Val Lys Val Gln Leu Gln Lys Leu Glu Lys Gln Asn 370 375 380 Val Ser Ser Val Ile Ile Asp Leu Arg Ser Asn Gly Gly Gly Ala Leu 385 390 395 400 Thr Glu Ala Val Ser Leu Ser Gly Leu Phe Ile Pro Ala Gly Pro Ile 405 410 415 Val Gln Val Arg Asp Asn Asn Gly Lys Val Arg Glu Asp Ser Asp Thr 420 425 430 Asp Gly Gln Val Phe Tyr Lys Gly Pro Leu Val Val Leu Val Asp Arg 435 440 445 Phe Ser Ala Ser Ala Ser Glu Ile Phe Ala Ala Ala Met Gln Asp Tyr 450 455 460 Gly Arg Ala Leu Val Val Gly Glu Pro Thr Phe Gly Lys Gly Thr Val 465 470 475 480 Page 387 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Gln Tyr Arg Ser Leu Asn Arg Ile Tyr Asp Gln Met Leu Arg Pro 485 490 495 Glu Trp Pro Ala Leu Gly Ser Val Gln Tyr Thr Ile Gln Lys Phe Tyr 500 505 510 Arg Val Asn Gly Gly Ser Thr Gln Arg Lys Gly Val Thr Pro Asp Ile 515 520 525 Ile Met Pro Thr Gly Asn Glu Glu Thr Glu Thr Gly Glu Lys Phe Glu 530 535 540 Asp Asn Ala Leu Pro Trp Asp Ser Ile Asp Ala Ala Thr Tyr Val Lys 545 550 555 560 Ser Gly Asp Leu Thr Ala Phe Glu Pro Glu Leu Leu Lys Glu His Asn 565 570 575 Ala Arg Ile Ala Lys Asp Pro Glu Phe Gln Asn Ile Met Lys Asp Ile 580 585 590 Ala Arg Phe Asn Ala Met Lys Asp Lys Arg Asn Ile Val Ser Leu Asn 595 600 605 Tyr Ala Val Arg Glu Lys Glu Asn Asn Glu Asp Asp Ala Thr Arg Leu 610 615 620 Ala Arg Leu Asn Glu Arg Phe Lys Arg Glu Gly Lys Pro Glu Leu Lys 625 630 635 640 Lys Leu Asp Asp Leu Pro Lys Asp Tyr Gln Glu Pro Asp Pro Tyr Leu 645 650 655 Asp Glu Thr Val Asn Ile Ala Leu Asp Leu Ala Lys Leu Glu Lys Ala 660 665 670 Arg Pro Ala Glu Gln Pro Ala Pro Val Lys 675 680 <210> 261 <211> 1551 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(1551) <400> 261 ttg ttc atg gca act tat atg act ttt tca tta aag caa tca ggg aga 48 Leu Phe Met Ala Thr Tyr Met Thr Phe Ser Leu Lys Gln Ser Gly Arg 1 5 10 15 gca atg agt aaa cac gac acc gac act tca gat caa cac gcc gcg aaa 96 Page 388 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Met Ser Lys His Asp Thr Asp Thr Ser Asp Gln His Ala Ala Lys 20 25 30 cgc cgc tgg ctt aat gcc cac gaa gag ggg tat cac aaa gcg atg ggc 144 Arg Arg Trp Leu Asn Ala His Glu Glu Gly Tyr His Lys Ala Met Gly 35 40 45 aat cgc cag gtg cag atg atc gcc att ggc ggc gcg att ggc acc ggc 192 Asn Arg Gln Val Gln Met Ile Ala Ile Gly Gly Ala Ile Gly Thr Gly 50 55 60 ttg ttt tta ggt gca gga gcc cga ctg caa atg gcg ggg ccc gca ctg 240 Leu Phe Leu Gly Ala Gly Ala Arg Leu Gln Met Ala Gly Pro Ala Leu 65 70 75 80 gca ctg gtt tat tta att tgt ggc ttg ttt tcg ttt ttt att ctg cgt 288 Ala Leu Val Tyr Leu Ile Cys Gly Leu Phe Ser Phe Phe Ile Leu Arg 85 90 95 gca ttg ggt gag ctg gtg cta cac cgc cct tcc agt ggc agt ttt gtt 336 Ala Leu Gly Glu Leu Val Leu His Arg Pro Ser Ser Gly Ser Phe Val 100 105 110 tct tat gcc cgt gag ttt ttg ggt gag aaa gcc gct tat gtt gct ggc 384 Ser Tyr Ala Arg Glu Phe Leu Gly Glu Lys Ala Ala Tyr Val Ala Gly 115 120 125 tgg atg tac ttc atc aac tgg gcg atg acg ggg att gtt gat att acc 432 Trp Met Tyr Phe Ile Asn Trp Ala Met Thr Gly Ile Val Asp Ile Thr 130 135 140 gcc gtc gct ctg tat atg cat tac tgg ggt gcg ttt ggc ggc gtg ccg 480 Ala Val Ala Leu Tyr Met His Tyr Trp Gly Ala Phe Gly Gly Val Pro 145 150 155 160 cag tgg gtc ttt gcg ctc gct gca ctt acc atc gtt ggc acc atg aat 528 Gln Trp Val Phe Ala Leu Ala Ala Leu Thr Ile Val Gly Thr Met Asn 165 170 175 atg atc ggt gtg aaa tgg ttt gcg gag atg gag ttc tgg ttt gcg ctt 576 Met Ile Gly Val Lys Trp Phe Ala Glu Met Glu Phe Trp Phe Ala Leu 180 185 190 att aaa gtg ctc gcc att gtg acc ttt ttg gtc gtg ggt aca gtg ttc 624 Ile Lys Val Leu Ala Ile Val Thr Phe Leu Val Val Gly Thr Val Phe 195 200 205 ctc ggt agt ggt cag ccg ctg gat ggc aac acc act ggc ttt cat tta 672 Leu Gly Ser Gly Gln Pro Leu Asp Gly Asn Thr Thr Gly Phe His Leu 210 215 220 atc acc gat aat ggc ggc ttc ttc ccc cac ggt ttg ctg cct gcg ctg 720 Ile Thr Asp Asn Gly Gly Phe Phe Pro His Gly Leu Leu Pro Ala Leu 225 230 235 240 gtg ttg att cag ggc gta gtg ttt gct ttt gcc tcc att gaa atg gtg 768 Val Leu Ile Gln Gly Val Val Phe Ala Phe Ala Ser Ile Glu Met Val 245 250 255 ggt aca gct gcc gga gaa tgt aaa gat ccg cag acc atg gtg cct aaa 816 Gly Thr Ala Ala Gly Glu Cys Lys Asp Pro Gln Thr Met Val Pro Lys 260 265 270 gcc att aac agt gtg att tgg cgt att ggc ctg ttt tac gtc ggc tcc 864 Ala Ile Asn Ser Val Ile Trp Arg Ile Gly Leu Phe Tyr Val Gly Ser 275 280 285 gtg gtg ttg ctg gtt atg tta ttg ccg tgg agc gcg tat cag gcg ggg 912 Page 389 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Val Leu Leu Val Met Leu Leu Pro Trp Ser Ala Tyr Gln Ala Gly 290 295 300 caa agt ccg ttc gtg acg ttt ttc tct aaa ctg ggt gtg cca tat atc 960 Gln Ser Pro Phe Val Thr Phe Phe Ser Lys Leu Gly Val Pro Tyr Ile 305 310 315 320 ggc agc att atg aac att gtg gtg ctg acc gct gcc ctc tcc agc ctg 1008 Gly Ser Ile Met Asn Ile Val Val Leu Thr Ala Ala Leu Ser Ser Leu 325 330 335 aat tca ggt ctg tac tgc acc gga cgt att ctg cgc tca atg gcg atg 1056 Asn Ser Gly Leu Tyr Cys Thr Gly Arg Ile Leu Arg Ser Met Ala Met 340 345 350 ggc ggt tcc gca ccg agt ttt atg gcg aaa atg agt cgt cag cat gtg 1104 Gly Gly Ser Ala Pro Ser Phe Met Ala Lys Met Ser Arg Gln His Val 355 360 365 ccg tat gcc ggg att ctg gcg aca cta gtt gtg tat gtc gtc ggc gta 1152 Pro Tyr Ala Gly Ile Leu Ala Thr Leu Val Val Tyr Val Val Gly Val 370 375 380 ttc ctc aac tat ctg gtg ccg tcg cgc gta ttt gag att gtg ttg aac 1200 Phe Leu Asn Tyr Leu Val Pro Ser Arg Val Phe Glu Ile Val Leu Asn 385 390 395 400 ttc gcg tcg ctg gga atc atc gct tca tgg gcg ttt atc atc gtg tgc 1248 Phe Ala Ser Leu Gly Ile Ile Ala Ser Trp Ala Phe Ile Ile Val Cys 405 410 415 cag atg cgc ctg cgt aaa gcg att aaa gaa ggc aaa gca gcg gat gtc 1296 Gln Met Arg Leu Arg Lys Ala Ile Lys Glu Gly Lys Ala Ala Asp Val 420 425 430 agt ttt aaa ctg cct ggc gcg ccc ttc act tcc tgg ctg aca tta ctg 1344 Ser Phe Lys Leu Pro Gly Ala Pro Phe Thr Ser Trp Leu Thr Leu Leu 435 440 445 ttt tta ctg agt gtc ctt gtg ctg atg gcg ttc gat tac ccg aac ggg 1392 Phe Leu Leu Ser Val Leu Val Leu Met Ala Phe Asp Tyr Pro Asn Gly 450 455 460 act tat act atc gcg gcg ctg ccg att atc ggt att ttg ctg gtt ata 1440 Thr Tyr Thr Ile Ala Ala Leu Pro Ile Ile Gly Ile Leu Leu Val Ile 465 470 475 480 ggc tgg ttt ggt gtg cgc aaa cgc gtt gct gaa att cac agc act gcg 1488 Gly Trp Phe Gly Val Arg Lys Arg Val Ala Glu Ile His Ser Thr Ala 485 490 495 cca gtc gtc gag gaa gat gaa gaa aaa cag gaa att gtg ttt aag cct 1536 Pro Val Val Glu Glu Asp Glu Glu Lys Gln Glu Ile Val Phe Lys Pro 500 505 510 gaa acg gcg agt taa 1551 Glu Thr Ala Ser 515 <210> 262 <211> 516 <212> PRT <213> Escherichia coli <400> 262 Leu Phe Met Ala Thr Tyr Met Thr Phe Ser Leu Lys Gln Ser Gly Arg Page 390 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 Ala Met Ser Lys His Asp Thr Asp Thr Ser Asp Gln His Ala Ala Lys 20 25 30 Arg Arg Trp Leu Asn Ala His Glu Glu Gly Tyr His Lys Ala Met Gly 35 40 45 Asn Arg Gln Val Gln Met Ile Ala Ile Gly Gly Ala Ile Gly Thr Gly 50 55 60 Leu Phe Leu Gly Ala Gly Ala Arg Leu Gln Met Ala Gly Pro Ala Leu 65 70 75 80 Ala Leu Val Tyr Leu Ile Cys Gly Leu Phe Ser Phe Phe Ile Leu Arg 85 90 95 Ala Leu Gly Glu Leu Val Leu His Arg Pro Ser Ser Gly Ser Phe Val 100 105 110 Ser Tyr Ala Arg Glu Phe Leu Gly Glu Lys Ala Ala Tyr Val Ala Gly 115 120 125 Trp Met Tyr Phe Ile Asn Trp Ala Met Thr Gly Ile Val Asp Ile Thr 130 135 140 Ala Val Ala Leu Tyr Met His Tyr Trp Gly Ala Phe Gly Gly Val Pro 145 150 155 160 Gln Trp Val Phe Ala Leu Ala Ala Leu Thr Ile Val Gly Thr Met Asn 165 170 175 Met Ile Gly Val Lys Trp Phe Ala Glu Met Glu Phe Trp Phe Ala Leu 180 185 190 Ile Lys Val Leu Ala Ile Val Thr Phe Leu Val Val Gly Thr Val Phe 195 200 205 Leu Gly Ser Gly Gln Pro Leu Asp Gly Asn Thr Thr Gly Phe His Leu 210 215 220 Ile Thr Asp Asn Gly Gly Phe Phe Pro His Gly Leu Leu Pro Ala Leu 225 230 235 240 Val Leu Ile Gln Gly Val Val Phe Ala Phe Ala Ser Ile Glu Met Val 245 250 255 Gly Thr Ala Ala Gly Glu Cys Lys Asp Pro Gln Thr Met Val Pro Lys 260 265 270 Ala Ile Asn Ser Val Ile Trp Arg Ile Gly Leu Phe Tyr Val Gly Ser Page 391 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 275 280 285 Val Val Leu Leu Val Met Leu Leu Pro Trp Ser Ala Tyr Gln Ala Gly 290 295 300 Gln Ser Pro Phe Val Thr Phe Phe Ser Lys Leu Gly Val Pro Tyr Ile 305 310 315 320 Gly Ser Ile Met Asn Ile Val Val Leu Thr Ala Ala Leu Ser Ser Leu 325 330 335 Asn Ser Gly Leu Tyr Cys Thr Gly Arg Ile Leu Arg Ser Met Ala Met 340 345 350 Gly Gly Ser Ala Pro Ser Phe Met Ala Lys Met Ser Arg Gln His Val 355 360 365 Pro Tyr Ala Gly Ile Leu Ala Thr Leu Val Val Tyr Val Val Gly Val 370 375 380 Phe Leu Asn Tyr Leu Val Pro Ser Arg Val Phe Glu Ile Val Leu Asn 385 390 395 400 Phe Ala Ser Leu Gly Ile Ile Ala Ser Trp Ala Phe Ile Ile Val Cys 405 410 415 Gln Met Arg Leu Arg Lys Ala Ile Lys Glu Gly Lys Ala Ala Asp Val 420 425 430 Ser Phe Lys Leu Pro Gly Ala Pro Phe Thr Ser Trp Leu Thr Leu Leu 435 440 445 Phe Leu Leu Ser Val Leu Val Leu Met Ala Phe Asp Tyr Pro Asn Gly 450 455 460 Thr Tyr Thr Ile Ala Ala Leu Pro Ile Ile Gly Ile Leu Leu Val Ile 465 470 475 480 Gly Trp Phe Gly Val Arg Lys Arg Val Ala Glu Ile His Ser Thr Ala 485 490 495 Pro Val Val Glu Glu Asp Glu Glu Lys Gln Glu Ile Val Phe Lys Pro 500 505 510 Glu Thr Ala Ser 515 <210> 263 <211> 681 <212> DNA <213> Escherichia coli Page 392 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(681) <400> 263 atg atc agg agt cac acc atg acc att acg tct ctg gat ggc tat cgc 48 Met Ile Arg Ser His Thr Met Thr Ile Thr Ser Leu Asp Gly Tyr Arg 1 5 10 15 tgg ctg aag aac gat att att cgc ggt aat ttt caa ccg gat gaa aaa 96 Trp Leu Lys Asn Asp Ile Ile Arg Gly Asn Phe Gln Pro Asp Glu Lys 20 25 30 tta cga atg agt ttg ctg aca tcg cgt tat gca ctt ggc gtt ggg ccg 144 Leu Arg Met Ser Leu Leu Thr Ser Arg Tyr Ala Leu Gly Val Gly Pro 35 40 45 tta cgg gaa gct ctt tcg caa ctg gtg gcg gaa cgg ctg gtc acg gtg 192 Leu Arg Glu Ala Leu Ser Gln Leu Val Ala Glu Arg Leu Val Thr Val 50 55 60 gtg aat caa aaa ggg tat cgg gtg gcg tct atg tca gag cag gag ctg 240 Val Asn Gln Lys Gly Tyr Arg Val Ala Ser Met Ser Glu Gln Glu Leu 65 70 75 80 ctc gat att ttc gac gcc cgc gcc aat atg gaa gcg atg tta gtg agt 288 Leu Asp Ile Phe Asp Ala Arg Ala Asn Met Glu Ala Met Leu Val Ser 85 90 95 ctg gcg att gcc cgc ggt ggc gat gag tgg gag gca gac gtt ctc gca 336 Leu Ala Ile Ala Arg Gly Gly Asp Glu Trp Glu Ala Asp Val Leu Ala 100 105 110 aaa gcg cat ctg ctg agt aag ctt gag gcc tgt gac gcc agc gag aaa 384 Lys Ala His Leu Leu Ser Lys Leu Glu Ala Cys Asp Ala Ser Glu Lys 115 120 125 atg ctt gat gag tgg gat ctg cgt cat cag gcg ttt cat acg gca att 432 Met Leu Asp Glu Trp Asp Leu Arg His Gln Ala Phe His Thr Ala Ile 130 135 140 gtg gcg ggc tgt ggt tct cac tat ttg ctg caa atg cgt gaa cgg ttg 480 Val Ala Gly Cys Gly Ser His Tyr Leu Leu Gln Met Arg Glu Arg Leu 145 150 155 160 ttt gat ctg gcg gcg cgt tat cga ttt atc tgg ctg cgg cga acg gtg 528 Phe Asp Leu Ala Ala Arg Tyr Arg Phe Ile Trp Leu Arg Arg Thr Val 165 170 175 ctt tcg gtg gaa atg ctg gag gat aaa cac gat cag cac cag acc ctg 576 Leu Ser Val Glu Met Leu Glu Asp Lys His Asp Gln His Gln Thr Leu 180 185 190 act gcg gcg gta ctg gcg cga gat acc gcg cgc gcc agt gag tta atg 624 Thr Ala Ala Val Leu Ala Arg Asp Thr Ala Arg Ala Ser Glu Leu Met 195 200 205 cgc cag cat tta ctg acg cca att ccc att atc cag cag gcg atg gct 672 Arg Gln His Leu Leu Thr Pro Ile Pro Ile Ile Gln Gln Ala Met Ala 210 215 220 ggc aat taa 681 Gly Asn 225 <210> 264 Page 393 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 226 <212> PRT <213> Escherichia coli <400> 264 Met Ile Arg Ser His Thr Met Thr Ile Thr Ser Leu Asp Gly Tyr Arg 1 5 10 15 Trp Leu Lys Asn Asp Ile Ile Arg Gly Asn Phe Gln Pro Asp Glu Lys 20 25 30 Leu Arg Met Ser Leu Leu Thr Ser Arg Tyr Ala Leu Gly Val Gly Pro 35 40 45 Leu Arg Glu Ala Leu Ser Gln Leu Val Ala Glu Arg Leu Val Thr Val 50 55 60 Val Asn Gln Lys Gly Tyr Arg Val Ala Ser Met Ser Glu Gln Glu Leu 65 70 75 80 Leu Asp Ile Phe Asp Ala Arg Ala Asn Met Glu Ala Met Leu Val Ser 85 90 95 Leu Ala Ile Ala Arg Gly Gly Asp Glu Trp Glu Ala Asp Val Leu Ala 100 105 110 Lys Ala His Leu Leu Ser Lys Leu Glu Ala Cys Asp Ala Ser Glu Lys 115 120 125 Met Leu Asp Glu Trp Asp Leu Arg His Gln Ala Phe His Thr Ala Ile 130 135 140 Val Ala Gly Cys Gly Ser His Tyr Leu Leu Gln Met Arg Glu Arg Leu 145 150 155 160 Phe Asp Leu Ala Ala Arg Tyr Arg Phe Ile Trp Leu Arg Arg Thr Val 165 170 175 Leu Ser Val Glu Met Leu Glu Asp Lys His Asp Gln His Gln Thr Leu 180 185 190 Thr Ala Ala Val Leu Ala Arg Asp Thr Ala Arg Ala Ser Glu Leu Met 195 200 205 Arg Gln His Leu Leu Thr Pro Ile Pro Ile Ile Gln Gln Ala Met Ala 210 215 220 Gly Asn 225 <210> 265 <211> 1152 Page 394 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(1152) <400> 265 atg atg gct aac aga atg att ctg aac gaa acg gca tgg ttt ggt cgg 48 Met Met Ala Asn Arg Met Ile Leu Asn Glu Thr Ala Trp Phe Gly Arg 1 5 10 15 ggt gct gtt ggg gct tta acc gat gag gtg aaa cgc cgt ggt tat cag 96 Gly Ala Val Gly Ala Leu Thr Asp Glu Val Lys Arg Arg Gly Tyr Gln 20 25 30 aag gcg ctg atc gtc acc gat aaa acg ctg gtg caa tgc ggc gtg gtg 144 Lys Ala Leu Ile Val Thr Asp Lys Thr Leu Val Gln Cys Gly Val Val 35 40 45 gcg aaa gtg acc gat aag atg gat gct gca ggg ctg gca tgg gcg att 192 Ala Lys Val Thr Asp Lys Met Asp Ala Ala Gly Leu Ala Trp Ala Ile 50 55 60 tac gac ggc gta gtg ccc aac cca aca att act gtc gtc aaa gaa ggg 240 Tyr Asp Gly Val Val Pro Asn Pro Thr Ile Thr Val Val Lys Glu Gly 65 70 75 80 ctc ggt gta ttc cag aat agc ggc gcg gat tac ctg atc gct att ggt 288 Leu Gly Val Phe Gln Asn Ser Gly Ala Asp Tyr Leu Ile Ala Ile Gly 85 90 95 ggt ggt tct cca cag gat act tgt aaa gcg att ggc att atc agc aac 336 Gly Gly Ser Pro Gln Asp Thr Cys Lys Ala Ile Gly Ile Ile Ser Asn 100 105 110 aac ccg gag ttt gcc gat gtg cgt agc ctg gaa ggg ctt tcc ccg acc 384 Asn Pro Glu Phe Ala Asp Val Arg Ser Leu Glu Gly Leu Ser Pro Thr 115 120 125 aat aaa ccc agt gta ccg att ctg gca att cct acc aca gca ggt act 432 Asn Lys Pro Ser Val Pro Ile Leu Ala Ile Pro Thr Thr Ala Gly Thr 130 135 140 gcg gca gaa gtg acc att aac tac gtg atc act gac gaa gag aaa cgg 480 Ala Ala Glu Val Thr Ile Asn Tyr Val Ile Thr Asp Glu Glu Lys Arg 145 150 155 160 cgc aag ttt gtt tgc gtt gat ccg cat gat atc ccg cag gtg gcg ttt 528 Arg Lys Phe Val Cys Val Asp Pro His Asp Ile Pro Gln Val Ala Phe 165 170 175 att gac gct gac atg atg gat ggt atg cct cca gcg ctg aaa gct gcg 576 Ile Asp Ala Asp Met Met Asp Gly Met Pro Pro Ala Leu Lys Ala Ala 180 185 190 acg ggt gtc gat gcg ctc act cat gct att gag ggg tat att acc cgt 624 Thr Gly Val Asp Ala Leu Thr His Ala Ile Glu Gly Tyr Ile Thr Arg 195 200 205 ggc gcg tgg gcg cta acc gat gca ctg cac att aaa gcg att gaa atc 672 Gly Ala Trp Ala Leu Thr Asp Ala Leu His Ile Lys Ala Ile Glu Ile 210 215 220 att gct ggg gcg ctg cga gga tcg gtt gct ggt gat aag gat gcc gga 720 Ile Ala Gly Ala Leu Arg Gly Ser Val Ala Gly Asp Lys Asp Ala Gly 225 230 235 240 Page 395 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa gaa atg gcg ctc ggg cag tat gtt gcg ggt atg ggc ttc tcg aat 768 Glu Glu Met Ala Leu Gly Gln Tyr Val Ala Gly Met Gly Phe Ser Asn 245 250 255 gtt ggg tta ggg ttg gtg cat ggt atg gcg cat cca ctg ggc gcg ttt 816 Val Gly Leu Gly Leu Val His Gly Met Ala His Pro Leu Gly Ala Phe 260 265 270 tat aac act cca cac ggt gtt gcg aac gcc atc ctg tta ccg cat gtc 864 Tyr Asn Thr Pro His Gly Val Ala Asn Ala Ile Leu Leu Pro His Val 275 280 285 atg cgt tat aac gct gac ttt acc ggt gag aag tac cgc gat atc gcg 912 Met Arg Tyr Asn Ala Asp Phe Thr Gly Glu Lys Tyr Arg Asp Ile Ala 290 295 300 cgc gtt atg ggc gtg aaa gtg gaa ggt atg agc ctg gaa gag gcg cgt 960 Arg Val Met Gly Val Lys Val Glu Gly Met Ser Leu Glu Glu Ala Arg 305 310 315 320 aat gcc gct gtt gaa gcg gtg ttt gct ctc aac cgt gat gtc ggt att 1008 Asn Ala Ala Val Glu Ala Val Phe Ala Leu Asn Arg Asp Val Gly Ile 325 330 335 ccg cca cat ttg cgt gat gtt ggt gta cgc aag gaa gac att ccg gca 1056 Pro Pro His Leu Arg Asp Val Gly Val Arg Lys Glu Asp Ile Pro Ala 340 345 350 ctg gcg cag gcg gca ctg gat gat gtt tgt acc ggt ggc aac ccg cgt 1104 Leu Ala Gln Ala Ala Leu Asp Asp Val Cys Thr Gly Gly Asn Pro Arg 355 360 365 gaa gca acg ctt gag gat att gta gag ctt tac cat acc gcc tgg taa 1152 Glu Ala Thr Leu Glu Asp Ile Val Glu Leu Tyr His Thr Ala Trp 370 375 380 <210> 266 <211> 383 <212> PRT <213> Escherichia coli <400> 266 Met Met Ala Asn Arg Met Ile Leu Asn Glu Thr Ala Trp Phe Gly Arg 1 5 10 15 Gly Ala Val Gly Ala Leu Thr Asp Glu Val Lys Arg Arg Gly Tyr Gln 20 25 30 Lys Ala Leu Ile Val Thr Asp Lys Thr Leu Val Gln Cys Gly Val Val 35 40 45 Ala Lys Val Thr Asp Lys Met Asp Ala Ala Gly Leu Ala Trp Ala Ile 50 55 60 Tyr Asp Gly Val Val Pro Asn Pro Thr Ile Thr Val Val Lys Glu Gly 65 70 75 80 Leu Gly Val Phe Gln Asn Ser Gly Ala Asp Tyr Leu Ile Ala Ile Gly 85 90 95 Page 396 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Gly Ser Pro Gln Asp Thr Cys Lys Ala Ile Gly Ile Ile Ser Asn 100 105 110 Asn Pro Glu Phe Ala Asp Val Arg Ser Leu Glu Gly Leu Ser Pro Thr 115 120 125 Asn Lys Pro Ser Val Pro Ile Leu Ala Ile Pro Thr Thr Ala Gly Thr 130 135 140 Ala Ala Glu Val Thr Ile Asn Tyr Val Ile Thr Asp Glu Glu Lys Arg 145 150 155 160 Arg Lys Phe Val Cys Val Asp Pro His Asp Ile Pro Gln Val Ala Phe 165 170 175 Ile Asp Ala Asp Met Met Asp Gly Met Pro Pro Ala Leu Lys Ala Ala 180 185 190 Thr Gly Val Asp Ala Leu Thr His Ala Ile Glu Gly Tyr Ile Thr Arg 195 200 205 Gly Ala Trp Ala Leu Thr Asp Ala Leu His Ile Lys Ala Ile Glu Ile 210 215 220 Ile Ala Gly Ala Leu Arg Gly Ser Val Ala Gly Asp Lys Asp Ala Gly 225 230 235 240 Glu Glu Met Ala Leu Gly Gln Tyr Val Ala Gly Met Gly Phe Ser Asn 245 250 255 Val Gly Leu Gly Leu Val His Gly Met Ala His Pro Leu Gly Ala Phe 260 265 270 Tyr Asn Thr Pro His Gly Val Ala Asn Ala Ile Leu Leu Pro His Val 275 280 285 Met Arg Tyr Asn Ala Asp Phe Thr Gly Glu Lys Tyr Arg Asp Ile Ala 290 295 300 Arg Val Met Gly Val Lys Val Glu Gly Met Ser Leu Glu Glu Ala Arg 305 310 315 320 Asn Ala Ala Val Glu Ala Val Phe Ala Leu Asn Arg Asp Val Gly Ile 325 330 335 Pro Pro His Leu Arg Asp Val Gly Val Arg Lys Glu Asp Ile Pro Ala 340 345 350 Leu Ala Gln Ala Ala Leu Asp Asp Val Cys Thr Gly Gly Asn Pro Arg 355 360 365 Page 397 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Ala Thr Leu Glu Asp Ile Val Glu Leu Tyr His Thr Ala Trp 370 375 380 <210> 267 <211> 1197 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(1197) <400> 267 atg aat tat cgc tat cgc gcc atg acc cag gat ggt caa aaa ttg caa 48 Met Asn Tyr Arg Tyr Arg Ala Met Thr Gln Asp Gly Gln Lys Leu Gln 1 5 10 15 ggg atc att gat gct aac gat gaa cgt cag gca cga ctg cgg ctg cgt 96 Gly Ile Ile Asp Ala Asn Asp Glu Arg Gln Ala Arg Leu Arg Leu Arg 20 25 30 gaa gaa ggg ctt ttc ctg ctg gat att cgc ccc caa aaa agt tcg gga 144 Glu Glu Gly Leu Phe Leu Leu Asp Ile Arg Pro Gln Lys Ser Ser Gly 35 40 45 gta aaa aca cgt cgc ccg agg atc agc cat agt gaa ctg acg ctt ttc 192 Val Lys Thr Arg Arg Pro Arg Ile Ser His Ser Glu Leu Thr Leu Phe 50 55 60 acc cgg cag ttg gca acc tta agc gca gcg gca tta ccc ctg gaa gag 240 Thr Arg Gln Leu Ala Thr Leu Ser Ala Ala Ala Leu Pro Leu Glu Glu 65 70 75 80 agc ctt gcc gta atc ggt caa caa agc agt aat aaa cga ctg ggt gac 288 Ser Leu Ala Val Ile Gly Gln Gln Ser Ser Asn Lys Arg Leu Gly Asp 85 90 95 gtg tta aat cag gta cgc agc gcc atc ctt gaa ggg cat ccc ctt tcc 336 Val Leu Asn Gln Val Arg Ser Ala Ile Leu Glu Gly His Pro Leu Ser 100 105 110 gat gca tta cag cat ttt ccc acg ctt ttc gat tcg ctc tat cgt acc 384 Asp Ala Leu Gln His Phe Pro Thr Leu Phe Asp Ser Leu Tyr Arg Thr 115 120 125 ctg gta aaa gcg ggc gaa aag agc ggg ctg ctg gcc ccg gtg ttg gaa 432 Leu Val Lys Ala Gly Glu Lys Ser Gly Leu Leu Ala Pro Val Leu Glu 130 135 140 aag ctg gct gat tac aat gaa aac cgg cag aaa atc cgc agc aag ctc 480 Lys Leu Ala Asp Tyr Asn Glu Asn Arg Gln Lys Ile Arg Ser Lys Leu 145 150 155 160 att cag tca ctg atc tac ccc tgt atg ctc act acg gtg gcg att ggg 528 Ile Gln Ser Leu Ile Tyr Pro Cys Met Leu Thr Thr Val Ala Ile Gly 165 170 175 gtc gtg att att ctc ctc act gct gtc gtg ccc aaa att acc gaa cag 576 Val Val Ile Ile Leu Leu Thr Ala Val Val Pro Lys Ile Thr Glu Gln 180 185 190 ttc gtg cat atg aag cag caa ctg ccg ctg agt aca cgc att ctt tta 624 Phe Val His Met Lys Gln Gln Leu Pro Leu Ser Thr Arg Ile Leu Leu 195 200 205 Page 398 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggt ctg agc gac acg ttg caa cgt acc ggc ccg aca tta tta gcg aca 672 Gly Leu Ser Asp Thr Leu Gln Arg Thr Gly Pro Thr Leu Leu Ala Thr 210 215 220 gtg ttt att gtc gct gta ggt ttc tgg ctc tgg tta aaa cgc ggc aat 720 Val Phe Ile Val Ala Val Gly Phe Trp Leu Trp Leu Lys Arg Gly Asn 225 230 235 240 aac cgc cac cgt ttt cat gcc atg ttg ctg cgc gtt gcg ctc atc ggc 768 Asn Arg His Arg Phe His Ala Met Leu Leu Arg Val Ala Leu Ile Gly 245 250 255 ccg ctg att tgc gcc att aac agc gca cgc tat ctc cgc act tta agt 816 Pro Leu Ile Cys Ala Ile Asn Ser Ala Arg Tyr Leu Arg Thr Leu Ser 260 265 270 att ttg caa tcc agc ggc gtc cct ctg ctg gat ggg atg aat ttg tcc 864 Ile Leu Gln Ser Ser Gly Val Pro Leu Leu Asp Gly Met Asn Leu Ser 275 280 285 acc gaa agc ctc aac aac ctc gaa att cgc cag cgt ctg gca aat gcg 912 Thr Glu Ser Leu Asn Asn Leu Glu Ile Arg Gln Arg Leu Ala Asn Ala 290 295 300 gca gag aac gtt cgc cag ggt aac agc att cat ctt tcg ctg gaa caa 960 Ala Glu Asn Val Arg Gln Gly Asn Ser Ile His Leu Ser Leu Glu Gln 305 310 315 320 acc gca att ttc ccg ccg atg atg ctc tac atg gtg gcc tct ggc gaa 1008 Thr Ala Ile Phe Pro Pro Met Met Leu Tyr Met Val Ala Ser Gly Glu 325 330 335 aaa agc ggg cag ctc ggc aca tta atg gtc aga gcc gca gat aac cag 1056 Lys Ser Gly Gln Leu Gly Thr Leu Met Val Arg Ala Ala Asp Asn Gln 340 345 350 gag aca ctc caa caa aat cgg atc gcc tta acg ctc tcc atc ttc gag 1104 Glu Thr Leu Gln Gln Asn Arg Ile Ala Leu Thr Leu Ser Ile Phe Glu 355 360 365 cca gca ctc att att acg atg gca ctg atc gtc ctg ttt att gtc gtg 1152 Pro Ala Leu Ile Ile Thr Met Ala Leu Ile Val Leu Phe Ile Val Val 370 375 380 tcg gta ctc caa cct ctt ctt caa ctt aac tca atg att aat taa 1197 Ser Val Leu Gln Pro Leu Leu Gln Leu Asn Ser Met Ile Asn 385 390 395 <210> 268 <211> 398 <212> PRT <213> Escherichia coli <400> 268 Met Asn Tyr Arg Tyr Arg Ala Met Thr Gln Asp Gly Gln Lys Leu Gln 1 5 10 15 Gly Ile Ile Asp Ala Asn Asp Glu Arg Gln Ala Arg Leu Arg Leu Arg 20 25 30 Glu Glu Gly Leu Phe Leu Leu Asp Ile Arg Pro Gln Lys Ser Ser Gly 35 40 45 Page 399 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Lys Thr Arg Arg Pro Arg Ile Ser His Ser Glu Leu Thr Leu Phe 50 55 60 Thr Arg Gln Leu Ala Thr Leu Ser Ala Ala Ala Leu Pro Leu Glu Glu 65 70 75 80 Ser Leu Ala Val Ile Gly Gln Gln Ser Ser Asn Lys Arg Leu Gly Asp 85 90 95 Val Leu Asn Gln Val Arg Ser Ala Ile Leu Glu Gly His Pro Leu Ser 100 105 110 Asp Ala Leu Gln His Phe Pro Thr Leu Phe Asp Ser Leu Tyr Arg Thr 115 120 125 Leu Val Lys Ala Gly Glu Lys Ser Gly Leu Leu Ala Pro Val Leu Glu 130 135 140 Lys Leu Ala Asp Tyr Asn Glu Asn Arg Gln Lys Ile Arg Ser Lys Leu 145 150 155 160 Ile Gln Ser Leu Ile Tyr Pro Cys Met Leu Thr Thr Val Ala Ile Gly 165 170 175 Val Val Ile Ile Leu Leu Thr Ala Val Val Pro Lys Ile Thr Glu Gln 180 185 190 Phe Val His Met Lys Gln Gln Leu Pro Leu Ser Thr Arg Ile Leu Leu 195 200 205 Gly Leu Ser Asp Thr Leu Gln Arg Thr Gly Pro Thr Leu Leu Ala Thr 210 215 220 Val Phe Ile Val Ala Val Gly Phe Trp Leu Trp Leu Lys Arg Gly Asn 225 230 235 240 Asn Arg His Arg Phe His Ala Met Leu Leu Arg Val Ala Leu Ile Gly 245 250 255 Pro Leu Ile Cys Ala Ile Asn Ser Ala Arg Tyr Leu Arg Thr Leu Ser 260 265 270 Ile Leu Gln Ser Ser Gly Val Pro Leu Leu Asp Gly Met Asn Leu Ser 275 280 285 Thr Glu Ser Leu Asn Asn Leu Glu Ile Arg Gln Arg Leu Ala Asn Ala 290 295 300 Ala Glu Asn Val Arg Gln Gly Asn Ser Ile His Leu Ser Leu Glu Gln 305 310 315 320 Page 400 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Ala Ile Phe Pro Pro Met Met Leu Tyr Met Val Ala Ser Gly Glu 325 330 335 Lys Ser Gly Gln Leu Gly Thr Leu Met Val Arg Ala Ala Asp Asn Gln 340 345 350 Glu Thr Leu Gln Gln Asn Arg Ile Ala Leu Thr Leu Ser Ile Phe Glu 355 360 365 Pro Ala Leu Ile Ile Thr Met Ala Leu Ile Val Leu Phe Ile Val Val 370 375 380 Ser Val Leu Gln Pro Leu Leu Gln Leu Asn Ser Met Ile Asn 385 390 395 <210> 269 <211> 660 <212> DNA <213> Escherichia coli <220> <221> CDS <222> (1)..(660) <400> 269 atg gat cgt att gtt agt tct tca cat gac cgt aca tca ctg ctt agc 48 Met Asp Arg Ile Val Ser Ser Ser His Asp Arg Thr Ser Leu Leu Ser 1 5 10 15 acc cat aag gtg ctg cgt aat acc tat ttt ctg ctg agc ctg acg ctg 96 Thr His Lys Val Leu Arg Asn Thr Tyr Phe Leu Leu Ser Leu Thr Leu 20 25 30 gcc ttt tcg gcg att acc gca act gcc agt acg gtg ctg atg ctg cca 144 Ala Phe Ser Ala Ile Thr Ala Thr Ala Ser Thr Val Leu Met Leu Pro 35 40 45 tct ccg ggt ctg att ctg acg ctg gtg ggt atg tat ggt ttg atg ttc 192 Ser Pro Gly Leu Ile Leu Thr Leu Val Gly Met Tyr Gly Leu Met Phe 50 55 60 ctg acc tat aaa acg gcg aat aag ccg acc ggg att atc tcc gca ttc 240 Leu Thr Tyr Lys Thr Ala Asn Lys Pro Thr Gly Ile Ile Ser Ala Phe 65 70 75 80 gcc ttt acc ggt ttt ctg ggt tat atc ctc gga cct att ctg aac acc 288 Ala Phe Thr Gly Phe Leu Gly Tyr Ile Leu Gly Pro Ile Leu Asn Thr 85 90 95 tat ctg tct gcc gga atg ggt gac gta atc gct atg gca ctg ggc gga 336 Tyr Leu Ser Ala Gly Met Gly Asp Val Ile Ala Met Ala Leu Gly Gly 100 105 110 acg gcg tta gtg ttc ttc tgc tgc tct gca tat gtg ctg acc acc cgc 384 Thr Ala Leu Val Phe Phe Cys Cys Ser Ala Tyr Val Leu Thr Thr Arg 115 120 125 aaa gat atg tcg ttc ctc ggc ggt atg ctg atg gcg ggt att gtg gtg 432 Lys Asp Met Ser Phe Leu Gly Gly Met Leu Met Ala Gly Ile Val Val 130 135 140 gtg ctg att ggt atg gtt gcg aat atc ttc ctg cag ctg cct gct ctg 480 Page 401 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Leu Ile Gly Met Val Ala Asn Ile Phe Leu Gln Leu Pro Ala Leu 145 150 155 160 cat ctg gcg atc agc gcg gtc ttc att ctg atc tcc tct ggc gct atc 528 His Leu Ala Ile Ser Ala Val Phe Ile Leu Ile Ser Ser Gly Ala Ile 165 170 175 ttg ttt gaa acc agc aac atc att cat ggc ggt gag acg aac tat att 576 Leu Phe Glu Thr Ser Asn Ile Ile His Gly Gly Glu Thr Asn Tyr Ile 180 185 190 cgt gcc acg gtt agc ctg tat gtt tcg ctg tac aac atc ttc gtc agc 624 Arg Ala Thr Val Ser Leu Tyr Val Ser Leu Tyr Asn Ile Phe Val Ser 195 200 205 ctg ctg agc att ctg ggc ttc gct agc cgc gat taa 660 Leu Leu Ser Ile Leu Gly Phe Ala Ser Arg Asp 210 215 <210> 270 <211> 219 <212> PRT <213> Escherichia coli <400> 270 Met Asp Arg Ile Val Ser Ser Ser His Asp Arg Thr Ser Leu Leu Ser 1 5 10 15 Thr His Lys Val Leu Arg Asn Thr Tyr Phe Leu Leu Ser Leu Thr Leu 20 25 30 Ala Phe Ser Ala Ile Thr Ala Thr Ala Ser Thr Val Leu Met Leu Pro 35 40 45 Ser Pro Gly Leu Ile Leu Thr Leu Val Gly Met Tyr Gly Leu Met Phe 50 55 60 Leu Thr Tyr Lys Thr Ala Asn Lys Pro Thr Gly Ile Ile Ser Ala Phe 65 70 75 80 Ala Phe Thr Gly Phe Leu Gly Tyr Ile Leu Gly Pro Ile Leu Asn Thr 85 90 95 Tyr Leu Ser Ala Gly Met Gly Asp Val Ile Ala Met Ala Leu Gly Gly 100 105 110 Thr Ala Leu Val Phe Phe Cys Cys Ser Ala Tyr Val Leu Thr Thr Arg 115 120 125 Lys Asp Met Ser Phe Leu Gly Gly Met Leu Met Ala Gly Ile Val Val 130 135 140 Val Leu Ile Gly Met Val Ala Asn Ile Phe Leu Gln Leu Pro Ala Leu 145 150 155 160 His Leu Ala Ile Ser Ala Val Phe Ile Leu Ile Ser Ser Gly Ala Ile Page 402 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 165 170 175 Leu Phe Glu Thr Ser Asn Ile Ile His Gly Gly Glu Thr Asn Tyr Ile 180 185 190 Arg Ala Thr Val Ser Leu Tyr Val Ser Leu Tyr Asn Ile Phe Val Ser 195 200 205 Leu Leu Ser Ile Leu Gly Phe Ala Ser Arg Asp 210 215 <210> 271 <211> 1290 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1290) <400> 271 atg tcc aac aag ctg ttc agg tta gat gca ggc tac caa caa tac gac 48 Met Ser Asn Lys Leu Phe Arg Leu Asp Ala Gly Tyr Gln Gln Tyr Asp 1 5 10 15 tgg ggt aaa atc ggc tct tct tca gct gtc gct caa ttt gct gcc cat 96 Trp Gly Lys Ile Gly Ser Ser Ser Ala Val Ala Gln Phe Ala Ala His 20 25 30 tct gac ccc tct gtt caa att gaa caa gat aaa cca tat gca gag tta 144 Ser Asp Pro Ser Val Gln Ile Glu Gln Asp Lys Pro Tyr Ala Glu Leu 35 40 45 tgg atg ggt acc cac agc aag atg cct tcc tac aac cat gag tct aag 192 Trp Met Gly Thr His Ser Lys Met Pro Ser Tyr Asn His Glu Ser Lys 50 55 60 gaa tcc ctg aga gat atc atc tcc aag aac ccc tct gcc atg tta ggt 240 Glu Ser Leu Arg Asp Ile Ile Ser Lys Asn Pro Ser Ala Met Leu Gly 65 70 75 80 aag gac att att gat aag ttc cac gcc aca aat gaa ttg ccc ttc ctt 288 Lys Asp Ile Ile Asp Lys Phe His Ala Thr Asn Glu Leu Pro Phe Leu 85 90 95 ttc aaa gtt ttg tcc att gaa aaa gtc ttg tct att caa gca cat ccc 336 Phe Lys Val Leu Ser Ile Glu Lys Val Leu Ser Ile Gln Ala His Pro 100 105 110 gac aaa gcc ttg ggt aaa ata ttg cac gct caa gat cct aag aac tat 384 Asp Lys Ala Leu Gly Lys Ile Leu His Ala Gln Asp Pro Lys Asn Tyr 115 120 125 cct gat gat aat cac aaa cct gaa atg gcc atc gct gtg act gac ttt 432 Pro Asp Asp Asn His Lys Pro Glu Met Ala Ile Ala Val Thr Asp Phe 130 135 140 gaa ggt ttc tgc ggg ttc aaa cct ttg caa gag att gca gat gaa ttg 480 Glu Gly Phe Cys Gly Phe Lys Pro Leu Gln Glu Ile Ala Asp Glu Leu 145 150 155 160 aaa cgt att cct gaa tta cgc aac att gtt ggt gaa gaa act tcc agg 528 Lys Arg Ile Pro Glu Leu Arg Asn Ile Val Gly Glu Glu Thr Ser Arg Page 403 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 165 170 175 aat ttt att gag aac att caa cct tct gct cag aaa ggt tcc cca gaa 576 Asn Phe Ile Glu Asn Ile Gln Pro Ser Ala Gln Lys Gly Ser Pro Glu 180 185 190 gat gag caa aac aaa aag cta ttg caa gct gtt ttc agc agg gtc atg 624 Asp Glu Gln Asn Lys Lys Leu Leu Gln Ala Val Phe Ser Arg Val Met 195 200 205 aac gct tcg gat gac aaa atc aag att caa gct cgc tcc ttg gtc gaa 672 Asn Ala Ser Asp Asp Lys Ile Lys Ile Gln Ala Arg Ser Leu Val Glu 210 215 220 aga tca aag aat tct cca tca gac ttt aac aaa cct gat tta cca gaa 720 Arg Ser Lys Asn Ser Pro Ser Asp Phe Asn Lys Pro Asp Leu Pro Glu 225 230 235 240 tta att caa aga ctg aat aaa cag ttc cct gat gac gtg ggt ttg ttt 768 Leu Ile Gln Arg Leu Asn Lys Gln Phe Pro Asp Asp Val Gly Leu Phe 245 250 255 tgt gga tgt tta ttg ttg aat cac tgc aga ttg aat gct ggt gaa gcc 816 Cys Gly Cys Leu Leu Leu Asn His Cys Arg Leu Asn Ala Gly Glu Ala 260 265 270 atc ttt tta aga gct aag gat cct cac gcc tat ata agc ggt gat att 864 Ile Phe Leu Arg Ala Lys Asp Pro His Ala Tyr Ile Ser Gly Asp Ile 275 280 285 atg gaa tgt atg gct gct tct gac aac gta gtt aga gca ggc ttc act 912 Met Glu Cys Met Ala Ala Ser Asp Asn Val Val Arg Ala Gly Phe Thr 290 295 300 cca aaa ttc aag gat gtt aaa aac ttg gtc tcc atg tta acc tat aca 960 Pro Lys Phe Lys Asp Val Lys Asn Leu Val Ser Met Leu Thr Tyr Thr 305 310 315 320 tat gat cct gtg gaa aag caa aaa atg cag cct tta aag ttc gac agg 1008 Tyr Asp Pro Val Glu Lys Gln Lys Met Gln Pro Leu Lys Phe Asp Arg 325 330 335 tcc tct ggt aac ggt aag tca gtt tta tat aac cct cca atc gaa gaa 1056 Ser Ser Gly Asn Gly Lys Ser Val Leu Tyr Asn Pro Pro Ile Glu Glu 340 345 350 ttt gct gta ttg gag act act ttt gat gag aaa ctt ggt caa agg cat 1104 Phe Ala Val Leu Glu Thr Thr Phe Asp Glu Lys Leu Gly Gln Arg His 355 360 365 ttt gaa ggt gtt gat ggt cca agt atc tta atc act aca aaa ggt aat 1152 Phe Glu Gly Val Asp Gly Pro Ser Ile Leu Ile Thr Thr Lys Gly Asn 370 375 380 ggt tac att aaa gca gat ggc caa aaa ttg aaa gct gaa ccc ggt ttt 1200 Gly Tyr Ile Lys Ala Asp Gly Gln Lys Leu Lys Ala Glu Pro Gly Phe 385 390 395 400 gtc ttt ttc atc gct cca cat ttg cct gtt gat ttg gaa gct gaa gat 1248 Val Phe Phe Ile Ala Pro His Leu Pro Val Asp Leu Glu Ala Glu Asp 405 410 415 gag gcg ttt act acc tat aga gcc ttt gtg gaa cca aat tag 1290 Glu Ala Phe Thr Thr Tyr Arg Ala Phe Val Glu Pro Asn 420 425 <210> 272 Page 404 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 429 <212> PRT <213> Saccharomyces cerevisiae <400> 272 Met Ser Asn Lys Leu Phe Arg Leu Asp Ala Gly Tyr Gln Gln Tyr Asp 1 5 10 15 Trp Gly Lys Ile Gly Ser Ser Ser Ala Val Ala Gln Phe Ala Ala His 20 25 30 Ser Asp Pro Ser Val Gln Ile Glu Gln Asp Lys Pro Tyr Ala Glu Leu 35 40 45 Trp Met Gly Thr His Ser Lys Met Pro Ser Tyr Asn His Glu Ser Lys 50 55 60 Glu Ser Leu Arg Asp Ile Ile Ser Lys Asn Pro Ser Ala Met Leu Gly 65 70 75 80 Lys Asp Ile Ile Asp Lys Phe His Ala Thr Asn Glu Leu Pro Phe Leu 85 90 95 Phe Lys Val Leu Ser Ile Glu Lys Val Leu Ser Ile Gln Ala His Pro 100 105 110 Asp Lys Ala Leu Gly Lys Ile Leu His Ala Gln Asp Pro Lys Asn Tyr 115 120 125 Pro Asp Asp Asn His Lys Pro Glu Met Ala Ile Ala Val Thr Asp Phe 130 135 140 Glu Gly Phe Cys Gly Phe Lys Pro Leu Gln Glu Ile Ala Asp Glu Leu 145 150 155 160 Lys Arg Ile Pro Glu Leu Arg Asn Ile Val Gly Glu Glu Thr Ser Arg 165 170 175 Asn Phe Ile Glu Asn Ile Gln Pro Ser Ala Gln Lys Gly Ser Pro Glu 180 185 190 Asp Glu Gln Asn Lys Lys Leu Leu Gln Ala Val Phe Ser Arg Val Met 195 200 205 Asn Ala Ser Asp Asp Lys Ile Lys Ile Gln Ala Arg Ser Leu Val Glu 210 215 220 Arg Ser Lys Asn Ser Pro Ser Asp Phe Asn Lys Pro Asp Leu Pro Glu 225 230 235 240 Leu Ile Gln Arg Leu Asn Lys Gln Phe Pro Asp Asp Val Gly Leu Phe 245 250 255 Page 405 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Cys Gly Cys Leu Leu Leu Asn His Cys Arg Leu Asn Ala Gly Glu Ala 260 265 270 Ile Phe Leu Arg Ala Lys Asp Pro His Ala Tyr Ile Ser Gly Asp Ile 275 280 285 Met Glu Cys Met Ala Ala Ser Asp Asn Val Val Arg Ala Gly Phe Thr 290 295 300 Pro Lys Phe Lys Asp Val Lys Asn Leu Val Ser Met Leu Thr Tyr Thr 305 310 315 320 Tyr Asp Pro Val Glu Lys Gln Lys Met Gln Pro Leu Lys Phe Asp Arg 325 330 335 Ser Ser Gly Asn Gly Lys Ser Val Leu Tyr Asn Pro Pro Ile Glu Glu 340 345 350 Phe Ala Val Leu Glu Thr Thr Phe Asp Glu Lys Leu Gly Gln Arg His 355 360 365 Phe Glu Gly Val Asp Gly Pro Ser Ile Leu Ile Thr Thr Lys Gly Asn 370 375 380 Gly Tyr Ile Lys Ala Asp Gly Gln Lys Leu Lys Ala Glu Pro Gly Phe 385 390 395 400 Val Phe Phe Ile Ala Pro His Leu Pro Val Asp Leu Glu Ala Glu Asp 405 410 415 Glu Ala Phe Thr Thr Tyr Arg Ala Phe Val Glu Pro Asn 420 425 <210> 273 <211> 1539 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1539) <400> 273 atg gta gca aca ata atg cag acg aca aca act gtg ctg acg aca gtc 48 Met Val Ala Thr Ile Met Gln Thr Thr Thr Thr Val Leu Thr Thr Val 1 5 10 15 gcc gca atg tct act acc tta gca tca aat tac ata tct tcg caa gct 96 Ala Ala Met Ser Thr Thr Leu Ala Ser Asn Tyr Ile Ser Ser Gln Ala 20 25 30 agt tcc tcg acg agt gta aca aca gta acg aca ata gcg aca tca ata 144 Ser Ser Ser Thr Ser Val Thr Thr Val Thr Thr Ile Ala Thr Ser Ile 35 40 45 Page 406 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cgc tct aca ccg tct aat cta ctc ttt tct aat gtg gcg gct cag cca 192 Arg Ser Thr Pro Ser Asn Leu Leu Phe Ser Asn Val Ala Ala Gln Pro 50 55 60 aaa tca tct tca gca agc aca att ggg ctt tca atc gga ctt ccc atc 240 Lys Ser Ser Ser Ala Ser Thr Ile Gly Leu Ser Ile Gly Leu Pro Ile 65 70 75 80 gga ata ttc tgt ttc gga tta ctt atc ctt ttg tgt tat ttc tac ctt 288 Gly Ile Phe Cys Phe Gly Leu Leu Ile Leu Leu Cys Tyr Phe Tyr Leu 85 90 95 aaa agg aat tcg gtg tcc att tca aat cca ccc atg tca gct acg att 336 Lys Arg Asn Ser Val Ser Ile Ser Asn Pro Pro Met Ser Ala Thr Ile 100 105 110 cca agg gaa gag gaa tat tgt cgc cgc act aat tgg ttc tca cgg tta 384 Pro Arg Glu Glu Glu Tyr Cys Arg Arg Thr Asn Trp Phe Ser Arg Leu 115 120 125 ttt tgg cag agt aag tgt gag gat cag aat tca tat tct aat cgt gat 432 Phe Trp Gln Ser Lys Cys Glu Asp Gln Asn Ser Tyr Ser Asn Arg Asp 130 135 140 att gag aag tat aac gac acc cag tgg acc tcg ggt gat aac atg tct 480 Ile Glu Lys Tyr Asn Asp Thr Gln Trp Thr Ser Gly Asp Asn Met Ser 145 150 155 160 tca aaa ata cag tac aaa att tcc aaa ccc ata ata ccg cag cat ata 528 Ser Lys Ile Gln Tyr Lys Ile Ser Lys Pro Ile Ile Pro Gln His Ile 165 170 175 ctg aca cct aag aaa acg gtg aag aac cca tat gct tgg tct ggt aaa 576 Leu Thr Pro Lys Lys Thr Val Lys Asn Pro Tyr Ala Trp Ser Gly Lys 180 185 190 aac att tcg tta gac ccc aaa gtg aac gaa atg gag gaa gag aaa gtt 624 Asn Ile Ser Leu Asp Pro Lys Val Asn Glu Met Glu Glu Glu Lys Val 195 200 205 gtg gat gca ttc ctg tat act aaa cca ccg aat att gtc cat att gaa 672 Val Asp Ala Phe Leu Tyr Thr Lys Pro Pro Asn Ile Val His Ile Glu 210 215 220 tcc agc atg ccc tcg tat aat gat tta cct tct caa aaa acg gtg tcc 720 Ser Ser Met Pro Ser Tyr Asn Asp Leu Pro Ser Gln Lys Thr Val Ser 225 230 235 240 tca aag aaa act gcg tta aaa acg agt gag aaa tgg agt tac gaa tct 768 Ser Lys Lys Thr Ala Leu Lys Thr Ser Glu Lys Trp Ser Tyr Glu Ser 245 250 255 cca cta tct cga tgg ttc ttg agg ggt tct aca tac ttt aag gat tat 816 Pro Leu Ser Arg Trp Phe Leu Arg Gly Ser Thr Tyr Phe Lys Asp Tyr 260 265 270 ggc tta tca aag acc tct tta aag acc cca act ggg gct cca caa ctg 864 Gly Leu Ser Lys Thr Ser Leu Lys Thr Pro Thr Gly Ala Pro Gln Leu 275 280 285 aag caa atg aaa atg ctc tcc cgg ata agt aag ggt tac ttc aat gag 912 Lys Gln Met Lys Met Leu Ser Arg Ile Ser Lys Gly Tyr Phe Asn Glu 290 295 300 tca gat ata atg cct gac gaa cga tcg ccc atc ttg gag tat aat aac 960 Ser Asp Ile Met Pro Asp Glu Arg Ser Pro Ile Leu Glu Tyr Asn Asn 305 310 315 320 Page 407 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt acg cct ctg gat gca aat gac agt gtg aat aac ttg ggt aat acc acg 1008 Thr Pro Leu Asp Ala Asn Asp Ser Val Asn Asn Leu Gly Asn Thr Thr 325 330 335 cca gat tca caa atc aca tct tat cgc aac aat aac atc gat cta atc 1056 Pro Asp Ser Gln Ile Thr Ser Tyr Arg Asn Asn Asn Ile Asp Leu Ile 340 345 350 acg gca aga ccc cat tca gtg ata tac ggt act act gca caa caa act 1104 Thr Ala Arg Pro His Ser Val Ile Tyr Gly Thr Thr Ala Gln Gln Thr 355 360 365 ttg gaa acc aac ttc aat gat cat cat gac tgc aat aaa agc act gag 1152 Leu Glu Thr Asn Phe Asn Asp His His Asp Cys Asn Lys Ser Thr Glu 370 375 380 aaa cac gag ttg ata ata ccc acc cca tca aaa cca cta aag aaa agg 1200 Lys His Glu Leu Ile Ile Pro Thr Pro Ser Lys Pro Leu Lys Lys Arg 385 390 395 400 aaa aaa aga aga caa agt aaa atg tat cag cat tta caa cat ttg tca 1248 Lys Lys Arg Arg Gln Ser Lys Met Tyr Gln His Leu Gln His Leu Ser 405 410 415 cgt tct aaa cca ttg ccg ctt act cca aac tcc aaa tat aat ggg gag 1296 Arg Ser Lys Pro Leu Pro Leu Thr Pro Asn Ser Lys Tyr Asn Gly Glu 420 425 430 gct agc gtc caa tta ggg aag aca tat aca gtt att cag gat tac gag 1344 Ala Ser Val Gln Leu Gly Lys Thr Tyr Thr Val Ile Gln Asp Tyr Glu 435 440 445 cct aga ttg aca gac gaa ata aga atc tcg ctg ggt gaa aaa gtt aaa 1392 Pro Arg Leu Thr Asp Glu Ile Arg Ile Ser Leu Gly Glu Lys Val Lys 450 455 460 att ctg gcc act cat acc gat gga tgg tgt ctg gta gaa aag tgt aat 1440 Ile Leu Ala Thr His Thr Asp Gly Trp Cys Leu Val Glu Lys Cys Asn 465 470 475 480 aca caa aag ggt tct att cac gtc agt gtt gac gat aaa aga tac ctc 1488 Thr Gln Lys Gly Ser Ile His Val Ser Val Asp Asp Lys Arg Tyr Leu 485 490 495 aat gaa gat aga ggc att gtg cct ggt gac tgt ctc caa gaa tac gac 1536 Asn Glu Asp Arg Gly Ile Val Pro Gly Asp Cys Leu Gln Glu Tyr Asp 500 505 510 tga 1539 <210> 274 <211> 512 <212> PRT <213> Saccharomyces cerevisiae <400> 274 Met Val Ala Thr Ile Met Gln Thr Thr Thr Thr Val Leu Thr Thr Val 1 5 10 15 Ala Ala Met Ser Thr Thr Leu Ala Ser Asn Tyr Ile Ser Ser Gln Ala 20 25 30 Ser Ser Ser Thr Ser Val Thr Thr Val Thr Thr Ile Ala Thr Ser Ile Page 408 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 35 40 45 Arg Ser Thr Pro Ser Asn Leu Leu Phe Ser Asn Val Ala Ala Gln Pro 50 55 60 Lys Ser Ser Ser Ala Ser Thr Ile Gly Leu Ser Ile Gly Leu Pro Ile 65 70 75 80 Gly Ile Phe Cys Phe Gly Leu Leu Ile Leu Leu Cys Tyr Phe Tyr Leu 85 90 95 Lys Arg Asn Ser Val Ser Ile Ser Asn Pro Pro Met Ser Ala Thr Ile 100 105 110 Pro Arg Glu Glu Glu Tyr Cys Arg Arg Thr Asn Trp Phe Ser Arg Leu 115 120 125 Phe Trp Gln Ser Lys Cys Glu Asp Gln Asn Ser Tyr Ser Asn Arg Asp 130 135 140 Ile Glu Lys Tyr Asn Asp Thr Gln Trp Thr Ser Gly Asp Asn Met Ser 145 150 155 160 Ser Lys Ile Gln Tyr Lys Ile Ser Lys Pro Ile Ile Pro Gln His Ile 165 170 175 Leu Thr Pro Lys Lys Thr Val Lys Asn Pro Tyr Ala Trp Ser Gly Lys 180 185 190 Asn Ile Ser Leu Asp Pro Lys Val Asn Glu Met Glu Glu Glu Lys Val 195 200 205 Val Asp Ala Phe Leu Tyr Thr Lys Pro Pro Asn Ile Val His Ile Glu 210 215 220 Ser Ser Met Pro Ser Tyr Asn Asp Leu Pro Ser Gln Lys Thr Val Ser 225 230 235 240 Ser Lys Lys Thr Ala Leu Lys Thr Ser Glu Lys Trp Ser Tyr Glu Ser 245 250 255 Pro Leu Ser Arg Trp Phe Leu Arg Gly Ser Thr Tyr Phe Lys Asp Tyr 260 265 270 Gly Leu Ser Lys Thr Ser Leu Lys Thr Pro Thr Gly Ala Pro Gln Leu 275 280 285 Lys Gln Met Lys Met Leu Ser Arg Ile Ser Lys Gly Tyr Phe Asn Glu 290 295 300 Ser Asp Ile Met Pro Asp Glu Arg Ser Pro Ile Leu Glu Tyr Asn Asn Page 409 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 305 310 315 320 Thr Pro Leu Asp Ala Asn Asp Ser Val Asn Asn Leu Gly Asn Thr Thr 325 330 335 Pro Asp Ser Gln Ile Thr Ser Tyr Arg Asn Asn Asn Ile Asp Leu Ile 340 345 350 Thr Ala Arg Pro His Ser Val Ile Tyr Gly Thr Thr Ala Gln Gln Thr 355 360 365 Leu Glu Thr Asn Phe Asn Asp His His Asp Cys Asn Lys Ser Thr Glu 370 375 380 Lys His Glu Leu Ile Ile Pro Thr Pro Ser Lys Pro Leu Lys Lys Arg 385 390 395 400 Lys Lys Arg Arg Gln Ser Lys Met Tyr Gln His Leu Gln His Leu Ser 405 410 415 Arg Ser Lys Pro Leu Pro Leu Thr Pro Asn Ser Lys Tyr Asn Gly Glu 420 425 430 Ala Ser Val Gln Leu Gly Lys Thr Tyr Thr Val Ile Gln Asp Tyr Glu 435 440 445 Pro Arg Leu Thr Asp Glu Ile Arg Ile Ser Leu Gly Glu Lys Val Lys 450 455 460 Ile Leu Ala Thr His Thr Asp Gly Trp Cys Leu Val Glu Lys Cys Asn 465 470 475 480 Thr Gln Lys Gly Ser Ile His Val Ser Val Asp Asp Lys Arg Tyr Leu 485 490 495 Asn Glu Asp Arg Gly Ile Val Pro Gly Asp Cys Leu Gln Glu Tyr Asp 500 505 510 <210> 275 <211> 2901 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(2901) <400> 275 atg aat ccg ggc ggt gaa caa aca ata atg gaa caa ccc gct caa cag 48 Met Asn Pro Gly Gly Glu Gln Thr Ile Met Glu Gln Pro Ala Gln Gln 1 5 10 15 caa caa caa cag caa caa caa cag cag caa cag caa cag cag gca gca 96 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Ala Page 410 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 gtt cct cag cag cca ctc gac cca tta aca caa tca act gcg gaa act 144 Val Pro Gln Gln Pro Leu Asp Pro Leu Thr Gln Ser Thr Ala Glu Thr 35 40 45 tgg ctc tcc att gct tct ttg gca gaa acc ctt ggt gat ggc gac agg 192 Trp Leu Ser Ile Ala Ser Leu Ala Glu Thr Leu Gly Asp Gly Asp Arg 50 55 60 gcc gca atg gca tat gac gcc act tta cag ttc aat ccc tca tct gca 240 Ala Ala Met Ala Tyr Asp Ala Thr Leu Gln Phe Asn Pro Ser Ser Ala 65 70 75 80 aag gct tta aca tct ttg gct cac ttg tac cgt tcc aga gac atg ttc 288 Lys Ala Leu Thr Ser Leu Ala His Leu Tyr Arg Ser Arg Asp Met Phe 85 90 95 caa aga gct gca gaa tta tat gaa aga gca ctt ttg gta aat ccc gaa 336 Gln Arg Ala Ala Glu Leu Tyr Glu Arg Ala Leu Leu Val Asn Pro Glu 100 105 110 cta tca gat gtg tgg gct act tta ggt cat tgt tat ctg atg ctg gat 384 Leu Ser Asp Val Trp Ala Thr Leu Gly His Cys Tyr Leu Met Leu Asp 115 120 125 gat ctg caa aga gct tac aat gcc tat caa cag gct ctc tac cac ctc 432 Asp Leu Gln Arg Ala Tyr Asn Ala Tyr Gln Gln Ala Leu Tyr His Leu 130 135 140 agt aat ccc aac gta ccg aaa tta tgg cat gga atc ggc att ctt tat 480 Ser Asn Pro Asn Val Pro Lys Leu Trp His Gly Ile Gly Ile Leu Tyr 145 150 155 160 gac aga tat ggt tcg ctc gac tat gcc gaa gaa gct ttt gcc aaa gtt 528 Asp Arg Tyr Gly Ser Leu Asp Tyr Ala Glu Glu Ala Phe Ala Lys Val 165 170 175 ttg gaa ttg gac cct cat ttt gaa aag gca aac gaa att tac ttc aga 576 Leu Glu Leu Asp Pro His Phe Glu Lys Ala Asn Glu Ile Tyr Phe Arg 180 185 190 cta ggt att att tat aaa cat cag ggt aaa tgg tct caa gct ttg gaa 624 Leu Gly Ile Ile Tyr Lys His Gln Gly Lys Trp Ser Gln Ala Leu Glu 195 200 205 tgc ttc aga tac att ctc cct caa cct cct gct ccc ttg cag gag tgg 672 Cys Phe Arg Tyr Ile Leu Pro Gln Pro Pro Ala Pro Leu Gln Glu Trp 210 215 220 gac ata tgg ttt cag ttg ggt agt gtt ttg gag agt atg gga gag tgg 720 Asp Ile Trp Phe Gln Leu Gly Ser Val Leu Glu Ser Met Gly Glu Trp 225 230 235 240 caa ggt gcg aag gaa gcc tac gag cat gtc ttg gct caa aat caa cat 768 Gln Gly Ala Lys Glu Ala Tyr Glu His Val Leu Ala Gln Asn Gln His 245 250 255 cat gcc aaa gta tta caa caa tta ggt tgt ctt tac ggt atg agt aac 816 His Ala Lys Val Leu Gln Gln Leu Gly Cys Leu Tyr Gly Met Ser Asn 260 265 270 gta caa ttt tat gac cct caa aag gca ttg gat tat ctt cta aag tcg 864 Val Gln Phe Tyr Asp Pro Gln Lys Ala Leu Asp Tyr Leu Leu Lys Ser 275 280 285 tta gaa gca gat ccc tcc gat gcc act aca tgg tac cat ctc ggt aga 912 Leu Glu Ala Asp Pro Ser Asp Ala Thr Thr Trp Tyr His Leu Gly Arg Page 411 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 290 295 300 gtg cat atg att aga aca gat tat act gcc gca tat gat gct ttc caa 960 Val His Met Ile Arg Thr Asp Tyr Thr Ala Ala Tyr Asp Ala Phe Gln 305 310 315 320 caa gct gtt aat aga gat tca aga aac cct atc ttt tgg tgc tca atc 1008 Gln Ala Val Asn Arg Asp Ser Arg Asn Pro Ile Phe Trp Cys Ser Ile 325 330 335 ggt gtt tta tat tac caa att tct caa tac aga gac gcc tta gac gcg 1056 Gly Val Leu Tyr Tyr Gln Ile Ser Gln Tyr Arg Asp Ala Leu Asp Ala 340 345 350 tac aca aga gcc ata aga tta aat cct tat att agt gaa gtt tgg tac 1104 Tyr Thr Arg Ala Ile Arg Leu Asn Pro Tyr Ile Ser Glu Val Trp Tyr 355 360 365 gat cta ggt act ctt tac gaa act tgt aac aac caa tta tct gac gcc 1152 Asp Leu Gly Thr Leu Tyr Glu Thr Cys Asn Asn Gln Leu Ser Asp Ala 370 375 380 ctt gat gcg tat aag caa gct gca aga ctg gac gta aat aat gtt cac 1200 Leu Asp Ala Tyr Lys Gln Ala Ala Arg Leu Asp Val Asn Asn Val His 385 390 395 400 ata aga gaa aga tta gaa gct tta aca aag cag tta gaa aac cca ggc 1248 Ile Arg Glu Arg Leu Glu Ala Leu Thr Lys Gln Leu Glu Asn Pro Gly 405 410 415 aat ata aac aaa tcg aac ggt gcg cca acg aat gcc tct cct gcc cca 1296 Asn Ile Asn Lys Ser Asn Gly Ala Pro Thr Asn Ala Ser Pro Ala Pro 420 425 430 cct cct gtg att tta caa cct acc tta caa cct aat gat caa gga aat 1344 Pro Pro Val Ile Leu Gln Pro Thr Leu Gln Pro Asn Asp Gln Gly Asn 435 440 445 cct ttg aac act aga att tca gcc caa tct gcc aat gct act gct tca 1392 Pro Leu Asn Thr Arg Ile Ser Ala Gln Ser Ala Asn Ala Thr Ala Ser 450 455 460 atg gta caa caa cag cat cct gct caa caa acg cct att aac tct tct 1440 Met Val Gln Gln Gln His Pro Ala Gln Gln Thr Pro Ile Asn Ser Ser 465 470 475 480 gca aca atg tac agt aat gga gct tcc cct caa tta caa gct caa gct 1488 Ala Thr Met Tyr Ser Asn Gly Ala Ser Pro Gln Leu Gln Ala Gln Ala 485 490 495 caa gct caa gct caa gca caa gct caa gca caa gca caa gct caa gca 1536 Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala 500 505 510 caa gca caa gca caa gcg caa gca caa gca caa gca cag gcg caa gca 1584 Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala 515 520 525 cag gca caa gca caa gca caa gca cat gca caa gcg caa gca caa gca 1632 Gln Ala Gln Ala Gln Ala Gln Ala His Ala Gln Ala Gln Ala Gln Ala 530 535 540 caa gca cag gca caa gca caa gca cag gcg cag gca caa caa caa caa 1680 Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Gln Gln Gln 545 550 555 560 caa caa cag caa caa caa caa caa caa caa caa caa caa caa caa caa 1728 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Page 412 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 565 570 575 caa caa caa caa caa caa caa cag cag cag caa tta cag ccc cta cca 1776 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gln Pro Leu Pro 580 585 590 aga caa cag ctg cag caa aag gga gtt tct gtg caa atg tta aat cct 1824 Arg Gln Gln Leu Gln Gln Lys Gly Val Ser Val Gln Met Leu Asn Pro 595 600 605 caa caa ggg caa cca tat atc aca cag cca aca gtc ata caa gct cac 1872 Gln Gln Gly Gln Pro Tyr Ile Thr Gln Pro Thr Val Ile Gln Ala His 610 615 620 caa ctg caa cca ttt tct aca caa gct atg gaa cat ccg caa agc tct 1920 Gln Leu Gln Pro Phe Ser Thr Gln Ala Met Glu His Pro Gln Ser Ser 625 630 635 640 caa ctg cca cct caa cag caa caa cta caa tct gtt caa cat cca caa 1968 Gln Leu Pro Pro Gln Gln Gln Gln Leu Gln Ser Val Gln His Pro Gln 645 650 655 caa ctt caa ggc cag cct caa gcc caa gct ccc caa cct tta atc cag 2016 Gln Leu Gln Gly Gln Pro Gln Ala Gln Ala Pro Gln Pro Leu Ile Gln 660 665 670 cat aac gtg gaa cag aac gtt tta cct caa aag aga tac atg gaa ggt 2064 His Asn Val Glu Gln Asn Val Leu Pro Gln Lys Arg Tyr Met Glu Gly 675 680 685 gca atc cac act tta gta gat gcc gcc gta tcc agt agc acc cac aca 2112 Ala Ile His Thr Leu Val Asp Ala Ala Val Ser Ser Ser Thr His Thr 690 695 700 gag aat aac aca aag tct cct cgt caa cca acc cat gcc att cca acg 2160 Glu Asn Asn Thr Lys Ser Pro Arg Gln Pro Thr His Ala Ile Pro Thr 705 710 715 720 caa gct ccc gca aca gga ata acg aac gct gaa cca cag gta aag aag 2208 Gln Ala Pro Ala Thr Gly Ile Thr Asn Ala Glu Pro Gln Val Lys Lys 725 730 735 caa aag ttg aac tct cca aat tca aac atc aac aaa tta gta aat act 2256 Gln Lys Leu Asn Ser Pro Asn Ser Asn Ile Asn Lys Leu Val Asn Thr 740 745 750 gct act tcc att gaa gaa aat gca aaa tct gag gtg agc aac caa tcg 2304 Ala Thr Ser Ile Glu Glu Asn Ala Lys Ser Glu Val Ser Asn Gln Ser 755 760 765 cca gca gta gtg gag tct aat acc aat aat act tca caa gaa gaa aaa 2352 Pro Ala Val Val Glu Ser Asn Thr Asn Asn Thr Ser Gln Glu Glu Lys 770 775 780 cct gta aaa gca aac tca ata cct tca gta att ggc gca cag gaa cct 2400 Pro Val Lys Ala Asn Ser Ile Pro Ser Val Ile Gly Ala Gln Glu Pro 785 790 795 800 cca cag gaa gct agt cct gct gaa gaa gct acc aaa gca gct tct gtt 2448 Pro Gln Glu Ala Ser Pro Ala Glu Glu Ala Thr Lys Ala Ala Ser Val 805 810 815 tct cct tct aca aaa ccg ctt aat acg gaa cca gag tca tct agt gtc 2496 Ser Pro Ser Thr Lys Pro Leu Asn Thr Glu Pro Glu Ser Ser Ser Val 820 825 830 caa cca act gta tca tca gaa agt tca aca aca aaa gca aat gac caa 2544 Gln Pro Thr Val Ser Ser Glu Ser Ser Thr Thr Lys Ala Asn Asp Gln Page 413 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 835 840 845 agc act gct gag acc ata gaa ctt tct act gct act gtt cct gca gaa 2592 Ser Thr Ala Glu Thr Ile Glu Leu Ser Thr Ala Thr Val Pro Ala Glu 850 855 860 gca agc cct gta gaa gac gaa gta aga cag cat tct aaa gag gaa aac 2640 Ala Ser Pro Val Glu Asp Glu Val Arg Gln His Ser Lys Glu Glu Asn 865 870 875 880 ggc aca act gaa gca tct gca cct tct act gaa gag gcg gag cca gca 2688 Gly Thr Thr Glu Ala Ser Ala Pro Ser Thr Glu Glu Ala Glu Pro Ala 885 890 895 gct tcc aga gat gct gaa aaa caa caa gat gaa acc gct gct aca acg 2736 Ala Ser Arg Asp Ala Glu Lys Gln Gln Asp Glu Thr Ala Ala Thr Thr 900 905 910 ata act gta atc aaa cct act ttg gaa aca atg gaa aca gtg aaa gag 2784 Ile Thr Val Ile Lys Pro Thr Leu Glu Thr Met Glu Thr Val Lys Glu 915 920 925 gag gcc aaa atg cgt gag gaa gag caa aca tct caa gaa aaa tcc cca 2832 Glu Ala Lys Met Arg Glu Glu Glu Gln Thr Ser Gln Glu Lys Ser Pro 930 935 940 cag gag aac aca ctt cca aga gaa aat gta gta agg caa gtg gaa gaa 2880 Gln Glu Asn Thr Leu Pro Arg Glu Asn Val Val Arg Gln Val Glu Glu 945 950 955 960 gat gaa aac tac gac gac taa 2901 Asp Glu Asn Tyr Asp Asp 965 <210> 276 <211> 966 <212> PRT <213> Saccharomyces cerevisiae <400> 276 Met Asn Pro Gly Gly Glu Gln Thr Ile Met Glu Gln Pro Ala Gln Gln 1 5 10 15 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Ala Ala 20 25 30 Val Pro Gln Gln Pro Leu Asp Pro Leu Thr Gln Ser Thr Ala Glu Thr 35 40 45 Trp Leu Ser Ile Ala Ser Leu Ala Glu Thr Leu Gly Asp Gly Asp Arg 50 55 60 Ala Ala Met Ala Tyr Asp Ala Thr Leu Gln Phe Asn Pro Ser Ser Ala 65 70 75 80 Lys Ala Leu Thr Ser Leu Ala His Leu Tyr Arg Ser Arg Asp Met Phe 85 90 95 Gln Arg Ala Ala Glu Leu Tyr Glu Arg Ala Leu Leu Val Asn Pro Glu 100 105 110 Page 414 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Ser Asp Val Trp Ala Thr Leu Gly His Cys Tyr Leu Met Leu Asp 115 120 125 Asp Leu Gln Arg Ala Tyr Asn Ala Tyr Gln Gln Ala Leu Tyr His Leu 130 135 140 Ser Asn Pro Asn Val Pro Lys Leu Trp His Gly Ile Gly Ile Leu Tyr 145 150 155 160 Asp Arg Tyr Gly Ser Leu Asp Tyr Ala Glu Glu Ala Phe Ala Lys Val 165 170 175 Leu Glu Leu Asp Pro His Phe Glu Lys Ala Asn Glu Ile Tyr Phe Arg 180 185 190 Leu Gly Ile Ile Tyr Lys His Gln Gly Lys Trp Ser Gln Ala Leu Glu 195 200 205 Cys Phe Arg Tyr Ile Leu Pro Gln Pro Pro Ala Pro Leu Gln Glu Trp 210 215 220 Asp Ile Trp Phe Gln Leu Gly Ser Val Leu Glu Ser Met Gly Glu Trp 225 230 235 240 Gln Gly Ala Lys Glu Ala Tyr Glu His Val Leu Ala Gln Asn Gln His 245 250 255 His Ala Lys Val Leu Gln Gln Leu Gly Cys Leu Tyr Gly Met Ser Asn 260 265 270 Val Gln Phe Tyr Asp Pro Gln Lys Ala Leu Asp Tyr Leu Leu Lys Ser 275 280 285 Leu Glu Ala Asp Pro Ser Asp Ala Thr Thr Trp Tyr His Leu Gly Arg 290 295 300 Val His Met Ile Arg Thr Asp Tyr Thr Ala Ala Tyr Asp Ala Phe Gln 305 310 315 320 Gln Ala Val Asn Arg Asp Ser Arg Asn Pro Ile Phe Trp Cys Ser Ile 325 330 335 Gly Val Leu Tyr Tyr Gln Ile Ser Gln Tyr Arg Asp Ala Leu Asp Ala 340 345 350 Tyr Thr Arg Ala Ile Arg Leu Asn Pro Tyr Ile Ser Glu Val Trp Tyr 355 360 365 Asp Leu Gly Thr Leu Tyr Glu Thr Cys Asn Asn Gln Leu Ser Asp Ala 370 375 380 Page 415 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Asp Ala Tyr Lys Gln Ala Ala Arg Leu Asp Val Asn Asn Val His 385 390 395 400 Ile Arg Glu Arg Leu Glu Ala Leu Thr Lys Gln Leu Glu Asn Pro Gly 405 410 415 Asn Ile Asn Lys Ser Asn Gly Ala Pro Thr Asn Ala Ser Pro Ala Pro 420 425 430 Pro Pro Val Ile Leu Gln Pro Thr Leu Gln Pro Asn Asp Gln Gly Asn 435 440 445 Pro Leu Asn Thr Arg Ile Ser Ala Gln Ser Ala Asn Ala Thr Ala Ser 450 455 460 Met Val Gln Gln Gln His Pro Ala Gln Gln Thr Pro Ile Asn Ser Ser 465 470 475 480 Ala Thr Met Tyr Ser Asn Gly Ala Ser Pro Gln Leu Gln Ala Gln Ala 485 490 495 Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala 500 505 510 Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala 515 520 525 Gln Ala Gln Ala Gln Ala Gln Ala His Ala Gln Ala Gln Ala Gln Ala 530 535 540 Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Ala Gln Gln Gln Gln 545 550 555 560 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 565 570 575 Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Leu Gln Pro Leu Pro 580 585 590 Arg Gln Gln Leu Gln Gln Lys Gly Val Ser Val Gln Met Leu Asn Pro 595 600 605 Gln Gln Gly Gln Pro Tyr Ile Thr Gln Pro Thr Val Ile Gln Ala His 610 615 620 Gln Leu Gln Pro Phe Ser Thr Gln Ala Met Glu His Pro Gln Ser Ser 625 630 635 640 Gln Leu Pro Pro Gln Gln Gln Gln Leu Gln Ser Val Gln His Pro Gln 645 650 655 Page 416 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Leu Gln Gly Gln Pro Gln Ala Gln Ala Pro Gln Pro Leu Ile Gln 660 665 670 His Asn Val Glu Gln Asn Val Leu Pro Gln Lys Arg Tyr Met Glu Gly 675 680 685 Ala Ile His Thr Leu Val Asp Ala Ala Val Ser Ser Ser Thr His Thr 690 695 700 Glu Asn Asn Thr Lys Ser Pro Arg Gln Pro Thr His Ala Ile Pro Thr 705 710 715 720 Gln Ala Pro Ala Thr Gly Ile Thr Asn Ala Glu Pro Gln Val Lys Lys 725 730 735 Gln Lys Leu Asn Ser Pro Asn Ser Asn Ile Asn Lys Leu Val Asn Thr 740 745 750 Ala Thr Ser Ile Glu Glu Asn Ala Lys Ser Glu Val Ser Asn Gln Ser 755 760 765 Pro Ala Val Val Glu Ser Asn Thr Asn Asn Thr Ser Gln Glu Glu Lys 770 775 780 Pro Val Lys Ala Asn Ser Ile Pro Ser Val Ile Gly Ala Gln Glu Pro 785 790 795 800 Pro Gln Glu Ala Ser Pro Ala Glu Glu Ala Thr Lys Ala Ala Ser Val 805 810 815 Ser Pro Ser Thr Lys Pro Leu Asn Thr Glu Pro Glu Ser Ser Ser Val 820 825 830 Gln Pro Thr Val Ser Ser Glu Ser Ser Thr Thr Lys Ala Asn Asp Gln 835 840 845 Ser Thr Ala Glu Thr Ile Glu Leu Ser Thr Ala Thr Val Pro Ala Glu 850 855 860 Ala Ser Pro Val Glu Asp Glu Val Arg Gln His Ser Lys Glu Glu Asn 865 870 875 880 Gly Thr Thr Glu Ala Ser Ala Pro Ser Thr Glu Glu Ala Glu Pro Ala 885 890 895 Ala Ser Arg Asp Ala Glu Lys Gln Gln Asp Glu Thr Ala Ala Thr Thr 900 905 910 Ile Thr Val Ile Lys Pro Thr Leu Glu Thr Met Glu Thr Val Lys Glu 915 920 925 Page 417 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Ala Lys Met Arg Glu Glu Glu Gln Thr Ser Gln Glu Lys Ser Pro 930 935 940 Gln Glu Asn Thr Leu Pro Arg Glu Asn Val Val Arg Gln Val Glu Glu 945 950 955 960 Asp Glu Asn Tyr Asp Asp 965 <210> 277 <211> 600 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(600) <400> 277 atg gac aaa atc aga gaa aag cta agc aac ttg aag ttg gaa gcc gaa 48 Met Asp Lys Ile Arg Glu Lys Leu Ser Asn Leu Lys Leu Glu Ala Glu 1 5 10 15 tca tgg cag gag aag tac gag gag ttg aaa gag aag aac aag gac ttg 96 Ser Trp Gln Glu Lys Tyr Glu Glu Leu Lys Glu Lys Asn Lys Asp Leu 20 25 30 gag caa gag aac gtc gaa aag gag aat cag atc aag tct tta acc gtc 144 Glu Gln Glu Asn Val Glu Lys Glu Asn Gln Ile Lys Ser Leu Thr Val 35 40 45 aaa aac cag caa ttg gag gat gag atc gag aag ctg gaa gcg gga ctt 192 Lys Asn Gln Gln Leu Glu Asp Glu Ile Glu Lys Leu Glu Ala Gly Leu 50 55 60 tct gac tct aag caa aca gaa cag gat aac gtt gaa aaa gaa aat cag 240 Ser Asp Ser Lys Gln Thr Glu Gln Asp Asn Val Glu Lys Glu Asn Gln 65 70 75 80 atc aag tcc ttg acg gtg aag aac cac caa ttg gag gaa gag atc gag 288 Ile Lys Ser Leu Thr Val Lys Asn His Gln Leu Glu Glu Glu Ile Glu 85 90 95 aag ttg gaa gca gaa ttg gct gaa tcc aag caa ttg tcc gag gac tct 336 Lys Leu Glu Ala Glu Leu Ala Glu Ser Lys Gln Leu Ser Glu Asp Ser 100 105 110 cac cac ttg cag tcc aac aac gac aat ttc tcc aag aag aac cag caa 384 His His Leu Gln Ser Asn Asn Asp Asn Phe Ser Lys Lys Asn Gln Gln 115 120 125 ttg gaa gaa gac ttg gag gaa agc gac acc aag cta aag gaa acc act 432 Leu Glu Glu Asp Leu Glu Glu Ser Asp Thr Lys Leu Lys Glu Thr Thr 130 135 140 gag aaa ttg aga gag tcc gac ttg aag gca gat caa ttg gaa aga aga 480 Glu Lys Leu Arg Glu Ser Asp Leu Lys Ala Asp Gln Leu Glu Arg Arg 145 150 155 160 gta gct gcc ttg gaa gaa caa aga gaa gaa tgg gaa aga aag aac gag 528 Val Ala Ala Leu Glu Glu Gln Arg Glu Glu Trp Glu Arg Lys Asn Glu 165 170 175 Page 418 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa ttg acc gtc aag tac gaa gac gca aag aag gaa ctg gac gaa att 576 Glu Leu Thr Val Lys Tyr Glu Asp Ala Lys Lys Glu Leu Asp Glu Ile 180 185 190 gct gca tct ctg gaa aac ttg tga 600 Ala Ala Ser Leu Glu Asn Leu 195 <210> 278 <211> 199 <212> PRT <213> Saccharomyces cerevisiae <400> 278 Met Asp Lys Ile Arg Glu Lys Leu Ser Asn Leu Lys Leu Glu Ala Glu 1 5 10 15 Ser Trp Gln Glu Lys Tyr Glu Glu Leu Lys Glu Lys Asn Lys Asp Leu 20 25 30 Glu Gln Glu Asn Val Glu Lys Glu Asn Gln Ile Lys Ser Leu Thr Val 35 40 45 Lys Asn Gln Gln Leu Glu Asp Glu Ile Glu Lys Leu Glu Ala Gly Leu 50 55 60 Ser Asp Ser Lys Gln Thr Glu Gln Asp Asn Val Glu Lys Glu Asn Gln 65 70 75 80 Ile Lys Ser Leu Thr Val Lys Asn His Gln Leu Glu Glu Glu Ile Glu 85 90 95 Lys Leu Glu Ala Glu Leu Ala Glu Ser Lys Gln Leu Ser Glu Asp Ser 100 105 110 His His Leu Gln Ser Asn Asn Asp Asn Phe Ser Lys Lys Asn Gln Gln 115 120 125 Leu Glu Glu Asp Leu Glu Glu Ser Asp Thr Lys Leu Lys Glu Thr Thr 130 135 140 Glu Lys Leu Arg Glu Ser Asp Leu Lys Ala Asp Gln Leu Glu Arg Arg 145 150 155 160 Val Ala Ala Leu Glu Glu Gln Arg Glu Glu Trp Glu Arg Lys Asn Glu 165 170 175 Glu Leu Thr Val Lys Tyr Glu Asp Ala Lys Lys Glu Leu Asp Glu Ile 180 185 190 Ala Ala Ser Leu Glu Asn Leu 195 Page 419 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 279 <211> 603 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(603) <400> 279 atg gca ggt atc aag ttg acg cat aag ctt tat cag tat tat caa tta 48 Met Ala Gly Ile Lys Leu Thr His Lys Leu Tyr Gln Tyr Tyr Gln Leu 1 5 10 15 gcc aca agc ttt ttg tat gct gca tta ttg ata cgg tgg ctg ata tta 96 Ala Thr Ser Phe Leu Tyr Ala Ala Leu Leu Ile Arg Trp Leu Ile Leu 20 25 30 atg cca ctg gta ggg tct cgg ttt tta ccg gga gga atc cac gaa ttc 144 Met Pro Leu Val Gly Ser Arg Phe Leu Pro Gly Gly Ile His Glu Phe 35 40 45 ttg ata tat ttg atg ttt tat tcc agc atc atg gaa gtt att tgg ttg 192 Leu Ile Tyr Leu Met Phe Tyr Ser Ser Ile Met Glu Val Ile Trp Leu 50 55 60 ctt aga ttc cac ggg ttc aaa tat ggt ttg ctt tca aga acg ttt ttg 240 Leu Arg Phe His Gly Phe Lys Tyr Gly Leu Leu Ser Arg Thr Phe Leu 65 70 75 80 aaa gac cta aat ttt atc tat tta gtc agc gtg atc cat ttt tat gac 288 Lys Asp Leu Asn Phe Ile Tyr Leu Val Ser Val Ile His Phe Tyr Asp 85 90 95 gat tat gag cat gca ttg atc ctc aag aat gca tca tat tct agt ttc 336 Asp Tyr Glu His Ala Leu Ile Leu Lys Asn Ala Ser Tyr Ser Ser Phe 100 105 110 att att tcc tta tct tta tca cag gca tat tgc cat tgg tgc aaa ctt 384 Ile Ile Ser Leu Ser Leu Ser Gln Ala Tyr Cys His Trp Cys Lys Leu 115 120 125 ttt aaa cgt aag ggc gta aag gaa aga aca ctt gta tgg aag gtt aac 432 Phe Lys Arg Lys Gly Val Lys Glu Arg Thr Leu Val Trp Lys Val Asn 130 135 140 aca ttt gtt aca ttg cca att ctc tac ctg agt gaa ttt gca ttg cta 480 Thr Phe Val Thr Leu Pro Ile Leu Tyr Leu Ser Glu Phe Ala Leu Leu 145 150 155 160 cta tta aat atc cag gtt aag aac tat cat tct acc ccg act ttg gac 528 Leu Leu Asn Ile Gln Val Lys Asn Tyr His Ser Thr Pro Thr Leu Asp 165 170 175 ata atc aac agg gtg gtt tta cta gca tac ttc cct gta cta cta aca 576 Ile Ile Asn Arg Val Val Leu Leu Ala Tyr Phe Pro Val Leu Leu Thr 180 185 190 gca tac aaa aaa cta tta aca aaa tga 603 Ala Tyr Lys Lys Leu Leu Thr Lys 195 200 <210> 280 <211> 200 <212> PRT Page 420 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Saccharomyces cerevisiae <400> 280 Met Ala Gly Ile Lys Leu Thr His Lys Leu Tyr Gln Tyr Tyr Gln Leu 1 5 10 15 Ala Thr Ser Phe Leu Tyr Ala Ala Leu Leu Ile Arg Trp Leu Ile Leu 20 25 30 Met Pro Leu Val Gly Ser Arg Phe Leu Pro Gly Gly Ile His Glu Phe 35 40 45 Leu Ile Tyr Leu Met Phe Tyr Ser Ser Ile Met Glu Val Ile Trp Leu 50 55 60 Leu Arg Phe His Gly Phe Lys Tyr Gly Leu Leu Ser Arg Thr Phe Leu 65 70 75 80 Lys Asp Leu Asn Phe Ile Tyr Leu Val Ser Val Ile His Phe Tyr Asp 85 90 95 Asp Tyr Glu His Ala Leu Ile Leu Lys Asn Ala Ser Tyr Ser Ser Phe 100 105 110 Ile Ile Ser Leu Ser Leu Ser Gln Ala Tyr Cys His Trp Cys Lys Leu 115 120 125 Phe Lys Arg Lys Gly Val Lys Glu Arg Thr Leu Val Trp Lys Val Asn 130 135 140 Thr Phe Val Thr Leu Pro Ile Leu Tyr Leu Ser Glu Phe Ala Leu Leu 145 150 155 160 Leu Leu Asn Ile Gln Val Lys Asn Tyr His Ser Thr Pro Thr Leu Asp 165 170 175 Ile Ile Asn Arg Val Val Leu Leu Ala Tyr Phe Pro Val Leu Leu Thr 180 185 190 Ala Tyr Lys Lys Leu Leu Thr Lys 195 200 <210> 281 <211> 447 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(447) <400> 281 atg tgt gaa tca tca aat aag act gaa aat gat ata gtc aga ttg tca 48 Page 421 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Cys Glu Ser Ser Asn Lys Thr Glu Asn Asp Ile Val Arg Leu Ser 1 5 10 15 caa gct atg gat gtc ctg gct aag ttg atc att tca aag caa aaa gat 96 Gln Ala Met Asp Val Leu Ala Lys Leu Ile Ile Ser Lys Gln Lys Asp 20 25 30 gga tca caa tta caa gtt gag tac gag cat aag ttg aaa gaa tta gag 144 Gly Ser Gln Leu Gln Val Glu Tyr Glu His Lys Leu Lys Glu Leu Glu 35 40 45 aaa ttc att aac cta cta ctg gga ttg cat gaa agc act gtg gga agt 192 Lys Phe Ile Asn Leu Leu Leu Gly Leu His Glu Ser Thr Val Gly Ser 50 55 60 atg atg aat act agt gtt ctt gac atg gta ctg cgg aat gga ata gag 240 Met Met Asn Thr Ser Val Leu Asp Met Val Leu Arg Asn Gly Ile Glu 65 70 75 80 atc atg gaa aaa gac gat caa aaa tat gcc ctg ata ccg att aaa gcc 288 Ile Met Glu Lys Asp Asp Gln Lys Tyr Ala Leu Ile Pro Ile Lys Ala 85 90 95 aag gaa gag gca gat aaa act acg agc act att cag gga gta acc agc 336 Lys Glu Glu Ala Asp Lys Thr Thr Ser Thr Ile Gln Gly Val Thr Ser 100 105 110 aaa aag agt agt aaa aag aaa aaa aat aag ata aaa tgt tca ttt tgt 384 Lys Lys Ser Ser Lys Lys Lys Lys Asn Lys Ile Lys Cys Ser Phe Cys 115 120 125 cac gag gct ggc cac aca agg gca cac tgc ggt gcg aga ctg aca gtt 432 His Glu Ala Gly His Thr Arg Ala His Cys Gly Ala Arg Leu Thr Val 130 135 140 ata ccc aag aaa taa 447 Ile Pro Lys Lys 145 <210> 282 <211> 148 <212> PRT <213> Saccharomyces cerevisiae <400> 282 Met Cys Glu Ser Ser Asn Lys Thr Glu Asn Asp Ile Val Arg Leu Ser 1 5 10 15 Gln Ala Met Asp Val Leu Ala Lys Leu Ile Ile Ser Lys Gln Lys Asp 20 25 30 Gly Ser Gln Leu Gln Val Glu Tyr Glu His Lys Leu Lys Glu Leu Glu 35 40 45 Lys Phe Ile Asn Leu Leu Leu Gly Leu His Glu Ser Thr Val Gly Ser 50 55 60 Met Met Asn Thr Ser Val Leu Asp Met Val Leu Arg Asn Gly Ile Glu 65 70 75 80 Ile Met Glu Lys Asp Asp Gln Lys Tyr Ala Leu Ile Pro Ile Lys Ala Page 422 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Lys Glu Glu Ala Asp Lys Thr Thr Ser Thr Ile Gln Gly Val Thr Ser 100 105 110 Lys Lys Ser Ser Lys Lys Lys Lys Asn Lys Ile Lys Cys Ser Phe Cys 115 120 125 His Glu Ala Gly His Thr Arg Ala His Cys Gly Ala Arg Leu Thr Val 130 135 140 Ile Pro Lys Lys 145 <210> 283 <211> 1545 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(1545) <400> 283 atg gag gaa caa cgt gaa ata ctg gaa caa ttg aag aaa act ctg cag 48 Met Glu Glu Gln Arg Glu Ile Leu Glu Gln Leu Lys Lys Thr Leu Gln 1 5 10 15 atg cta act gta gag cca tct aaa aat aac caa atc gcc aac gaa gaa 96 Met Leu Thr Val Glu Pro Ser Lys Asn Asn Gln Ile Ala Asn Glu Glu 20 25 30 aag gaa aag aaa gaa aat gaa aat tcg tgg tgc atc ctc gag cac aat 144 Lys Glu Lys Lys Glu Asn Glu Asn Ser Trp Cys Ile Leu Glu His Asn 35 40 45 tat gag gat att gca cag gaa ttc att gat ttc att tac aag aac cct 192 Tyr Glu Asp Ile Ala Gln Glu Phe Ile Asp Phe Ile Tyr Lys Asn Pro 50 55 60 acc act tac cat gta gta tca ttt ttc gcg gag ctg tta gat aag cat 240 Thr Thr Tyr His Val Val Ser Phe Phe Ala Glu Leu Leu Asp Lys His 65 70 75 80 aac ttc aaa tac ttg agc gag aaa tcc aat tgg cag gac tcc att ggc 288 Asn Phe Lys Tyr Leu Ser Glu Lys Ser Asn Trp Gln Asp Ser Ile Gly 85 90 95 gaa gat ggt ggg aaa ttc tac act ata aga aat gga act aac cta tct 336 Glu Asp Gly Gly Lys Phe Tyr Thr Ile Arg Asn Gly Thr Asn Leu Ser 100 105 110 gcc ttt atc ctg ggc aaa aac tgg aga gcc gaa aag ggt gtc ggt gtc 384 Ala Phe Ile Leu Gly Lys Asn Trp Arg Ala Glu Lys Gly Val Gly Val 115 120 125 att gga tct cat gtg gac gct ttg acg gtc aaa ttg aag ccc gtc tcc 432 Ile Gly Ser His Val Asp Ala Leu Thr Val Lys Leu Lys Pro Val Ser 130 135 140 ttt aaa gac aca gcg gaa ggt tac gga aga att gct gtt gct ccc tat 480 Phe Lys Asp Thr Ala Glu Gly Tyr Gly Arg Ile Ala Val Ala Pro Tyr Page 423 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 gga ggt aca ctg aat gaa ttg tgg cta gac aga gac cta ggt att ggt 528 Gly Gly Thr Leu Asn Glu Leu Trp Leu Asp Arg Asp Leu Gly Ile Gly 165 170 175 ggt cgc ctt ctt tac aag aag aag ggc act aac gaa att aaa agc gcc 576 Gly Arg Leu Leu Tyr Lys Lys Lys Gly Thr Asn Glu Ile Lys Ser Ala 180 185 190 ttg gtt gat tct aca ccc cta cct gtt tgt cga att cct tcc ttg gct 624 Leu Val Asp Ser Thr Pro Leu Pro Val Cys Arg Ile Pro Ser Leu Ala 195 200 205 ccc cat ttc ggt aaa cct gct gaa ggc cca ttt gat aaa gag gac caa 672 Pro His Phe Gly Lys Pro Ala Glu Gly Pro Phe Asp Lys Glu Asp Gln 210 215 220 act atc ccg gtc atc ggc ttc ccc act ccg gat gag gaa ggt aat gaa 720 Thr Ile Pro Val Ile Gly Phe Pro Thr Pro Asp Glu Glu Gly Asn Glu 225 230 235 240 cct ccc acg gat gat gaa aag aaa tcg ccc tta ttt ggc aaa cac tgc 768 Pro Pro Thr Asp Asp Glu Lys Lys Ser Pro Leu Phe Gly Lys His Cys 245 250 255 atc cac ctg tta agg tac gtt gcc aaa tta gcc ggt gtg gaa gtg tcc 816 Ile His Leu Leu Arg Tyr Val Ala Lys Leu Ala Gly Val Glu Val Ser 260 265 270 gaa ttg att caa atg gat tta gac tta ttc gat gtg caa aag ggt acc 864 Glu Leu Ile Gln Met Asp Leu Asp Leu Phe Asp Val Gln Lys Gly Thr 275 280 285 att gga ggt att ggt aaa cac ttc ctt ttt gca cca cgt cta gat gac 912 Ile Gly Gly Ile Gly Lys His Phe Leu Phe Ala Pro Arg Leu Asp Asp 290 295 300 agg ttg tgt agt ttc gca gca atg att gct ttg att tgc tac gct aag 960 Arg Leu Cys Ser Phe Ala Ala Met Ile Ala Leu Ile Cys Tyr Ala Lys 305 310 315 320 gat gtt aat acc gag gaa tca gat tta ttc tct act gtc act ttg tat 1008 Asp Val Asn Thr Glu Glu Ser Asp Leu Phe Ser Thr Val Thr Leu Tyr 325 330 335 gat aat gaa gaa atc gga tcg ttg aca aga caa ggc gca aaa ggt ggc 1056 Asp Asn Glu Glu Ile Gly Ser Leu Thr Arg Gln Gly Ala Lys Gly Gly 340 345 350 ttg ttg gag tca gtg gtg gaa cgc agt tct tct gca ttc act aag aaa 1104 Leu Leu Glu Ser Val Val Glu Arg Ser Ser Ser Ala Phe Thr Lys Lys 355 360 365 ccg gtc gat ttg cat acg gtt tgg gct aat tcc atc atc ttg tcc gca 1152 Pro Val Asp Leu His Thr Val Trp Ala Asn Ser Ile Ile Leu Ser Ala 370 375 380 gac gtc aac cac ctc tac aac cca aac ttt cct gaa gtc tat ttg aag 1200 Asp Val Asn His Leu Tyr Asn Pro Asn Phe Pro Glu Val Tyr Leu Lys 385 390 395 400 aat cat ttt cca gtg cct aat gtc gga atc act tta tca ctg gat cct 1248 Asn His Phe Pro Val Pro Asn Val Gly Ile Thr Leu Ser Leu Asp Pro 405 410 415 aac ggt cat atg gcc aca gat gtc gta gga act gcc cta gta gaa gaa 1296 Asn Gly His Met Ala Thr Asp Val Val Gly Thr Ala Leu Val Glu Glu Page 424 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 420 425 430 tta gca cgc cgc aat gga gac aaa gtg caa tat ttc caa atc aaa aac 1344 Leu Ala Arg Arg Asn Gly Asp Lys Val Gln Tyr Phe Gln Ile Lys Asn 435 440 445 aac tca aga tca ggt ggt act atc ggc cca tca ttg gct tct caa aca 1392 Asn Ser Arg Ser Gly Gly Thr Ile Gly Pro Ser Leu Ala Ser Gln Thr 450 455 460 ggt gct cgt acc ata gac ctg gga att gca cag ttg tcc atg cac agc 1440 Gly Ala Arg Thr Ile Asp Leu Gly Ile Ala Gln Leu Ser Met His Ser 465 470 475 480 atc aga gct gct aca ggg tcc aag gat gtc gga tta ggt gtt aag ttc 1488 Ile Arg Ala Ala Thr Gly Ser Lys Asp Val Gly Leu Gly Val Lys Phe 485 490 495 ttc aac gga ttt ttc aag cac tgg aga tca gtc tac gat gaa ttc ggc 1536 Phe Asn Gly Phe Phe Lys His Trp Arg Ser Val Tyr Asp Glu Phe Gly 500 505 510 gag ttg tga 1545 Glu Leu <210> 284 <211> 514 <212> PRT <213> Saccharomyces cerevisiae <400> 284 Met Glu Glu Gln Arg Glu Ile Leu Glu Gln Leu Lys Lys Thr Leu Gln 1 5 10 15 Met Leu Thr Val Glu Pro Ser Lys Asn Asn Gln Ile Ala Asn Glu Glu 20 25 30 Lys Glu Lys Lys Glu Asn Glu Asn Ser Trp Cys Ile Leu Glu His Asn 35 40 45 Tyr Glu Asp Ile Ala Gln Glu Phe Ile Asp Phe Ile Tyr Lys Asn Pro 50 55 60 Thr Thr Tyr His Val Val Ser Phe Phe Ala Glu Leu Leu Asp Lys His 65 70 75 80 Asn Phe Lys Tyr Leu Ser Glu Lys Ser Asn Trp Gln Asp Ser Ile Gly 85 90 95 Glu Asp Gly Gly Lys Phe Tyr Thr Ile Arg Asn Gly Thr Asn Leu Ser 100 105 110 Ala Phe Ile Leu Gly Lys Asn Trp Arg Ala Glu Lys Gly Val Gly Val 115 120 125 Ile Gly Ser His Val Asp Ala Leu Thr Val Lys Leu Lys Pro Val Ser 130 135 140 Page 425 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Lys Asp Thr Ala Glu Gly Tyr Gly Arg Ile Ala Val Ala Pro Tyr 145 150 155 160 Gly Gly Thr Leu Asn Glu Leu Trp Leu Asp Arg Asp Leu Gly Ile Gly 165 170 175 Gly Arg Leu Leu Tyr Lys Lys Lys Gly Thr Asn Glu Ile Lys Ser Ala 180 185 190 Leu Val Asp Ser Thr Pro Leu Pro Val Cys Arg Ile Pro Ser Leu Ala 195 200 205 Pro His Phe Gly Lys Pro Ala Glu Gly Pro Phe Asp Lys Glu Asp Gln 210 215 220 Thr Ile Pro Val Ile Gly Phe Pro Thr Pro Asp Glu Glu Gly Asn Glu 225 230 235 240 Pro Pro Thr Asp Asp Glu Lys Lys Ser Pro Leu Phe Gly Lys His Cys 245 250 255 Ile His Leu Leu Arg Tyr Val Ala Lys Leu Ala Gly Val Glu Val Ser 260 265 270 Glu Leu Ile Gln Met Asp Leu Asp Leu Phe Asp Val Gln Lys Gly Thr 275 280 285 Ile Gly Gly Ile Gly Lys His Phe Leu Phe Ala Pro Arg Leu Asp Asp 290 295 300 Arg Leu Cys Ser Phe Ala Ala Met Ile Ala Leu Ile Cys Tyr Ala Lys 305 310 315 320 Asp Val Asn Thr Glu Glu Ser Asp Leu Phe Ser Thr Val Thr Leu Tyr 325 330 335 Asp Asn Glu Glu Ile Gly Ser Leu Thr Arg Gln Gly Ala Lys Gly Gly 340 345 350 Leu Leu Glu Ser Val Val Glu Arg Ser Ser Ser Ala Phe Thr Lys Lys 355 360 365 Pro Val Asp Leu His Thr Val Trp Ala Asn Ser Ile Ile Leu Ser Ala 370 375 380 Asp Val Asn His Leu Tyr Asn Pro Asn Phe Pro Glu Val Tyr Leu Lys 385 390 395 400 Asn His Phe Pro Val Pro Asn Val Gly Ile Thr Leu Ser Leu Asp Pro 405 410 415 Page 426 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Gly His Met Ala Thr Asp Val Val Gly Thr Ala Leu Val Glu Glu 420 425 430 Leu Ala Arg Arg Asn Gly Asp Lys Val Gln Tyr Phe Gln Ile Lys Asn 435 440 445 Asn Ser Arg Ser Gly Gly Thr Ile Gly Pro Ser Leu Ala Ser Gln Thr 450 455 460 Gly Ala Arg Thr Ile Asp Leu Gly Ile Ala Gln Leu Ser Met His Ser 465 470 475 480 Ile Arg Ala Ala Thr Gly Ser Lys Asp Val Gly Leu Gly Val Lys Phe 485 490 495 Phe Asn Gly Phe Phe Lys His Trp Arg Ser Val Tyr Asp Glu Phe Gly 500 505 510 Glu Leu <210> 285 <211> 579 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(579) <400> 285 atg tct gaa aag gcc gtt aga agg aaa ctt gtt att att ggt gat ggt 48 Met Ser Glu Lys Ala Val Arg Arg Lys Leu Val Ile Ile Gly Asp Gly 1 5 10 15 gct tgt ggc aag acc tct tta cta tat gta ttt aca tta gga aaa ttc 96 Ala Cys Gly Lys Thr Ser Leu Leu Tyr Val Phe Thr Leu Gly Lys Phe 20 25 30 cct gaa caa tat cat ccg aca gtg ttc gag aat tat gtc act gat tgc 144 Pro Glu Gln Tyr His Pro Thr Val Phe Glu Asn Tyr Val Thr Asp Cys 35 40 45 aga gtt gac gga ata aaa gtg tcc tta acg ctc tgg gat aca gcg gga 192 Arg Val Asp Gly Ile Lys Val Ser Leu Thr Leu Trp Asp Thr Ala Gly 50 55 60 caa gag gaa tat gaa cgt tta cgt cca ttc tca tat tca aaa gca gat 240 Gln Glu Glu Tyr Glu Arg Leu Arg Pro Phe Ser Tyr Ser Lys Ala Asp 65 70 75 80 ata ata tta att ggg ttt gct gta gac aat ttt gaa tca cta att aac 288 Ile Ile Leu Ile Gly Phe Ala Val Asp Asn Phe Glu Ser Leu Ile Asn 85 90 95 gca agg acg aaa tgg gcg gat gag gca tta cga tat tgt cct gac gca 336 Ala Arg Thr Lys Trp Ala Asp Glu Ala Leu Arg Tyr Cys Pro Asp Ala 100 105 110 Page 427 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cca atc gtt ctt gta ggc ttg aaa aaa gat ttg agg caa gaa gcc cat 384 Pro Ile Val Leu Val Gly Leu Lys Lys Asp Leu Arg Gln Glu Ala His 115 120 125 ttt aaa gag aat gct acc gat gaa atg gtt ccc att gaa gat gca aaa 432 Phe Lys Glu Asn Ala Thr Asp Glu Met Val Pro Ile Glu Asp Ala Lys 130 135 140 caa gtt gca agg gcc att ggg gcc aag aaa tac atg gaa tgt agt gca 480 Gln Val Ala Arg Ala Ile Gly Ala Lys Lys Tyr Met Glu Cys Ser Ala 145 150 155 160 ctg act ggt gag ggt gtg gat gat gtc ttt gaa gta gct aca aga acc 528 Leu Thr Gly Glu Gly Val Asp Asp Val Phe Glu Val Ala Thr Arg Thr 165 170 175 agt ttg ctt atg aag aag gaa cca ggg gct aac tgt tgc ata att tta 576 Ser Leu Leu Met Lys Lys Glu Pro Gly Ala Asn Cys Cys Ile Ile Leu 180 185 190 taa 579 <210> 286 <211> 192 <212> PRT <213> Saccharomyces cerevisiae <400> 286 Met Ser Glu Lys Ala Val Arg Arg Lys Leu Val Ile Ile Gly Asp Gly 1 5 10 15 Ala Cys Gly Lys Thr Ser Leu Leu Tyr Val Phe Thr Leu Gly Lys Phe 20 25 30 Pro Glu Gln Tyr His Pro Thr Val Phe Glu Asn Tyr Val Thr Asp Cys 35 40 45 Arg Val Asp Gly Ile Lys Val Ser Leu Thr Leu Trp Asp Thr Ala Gly 50 55 60 Gln Glu Glu Tyr Glu Arg Leu Arg Pro Phe Ser Tyr Ser Lys Ala Asp 65 70 75 80 Ile Ile Leu Ile Gly Phe Ala Val Asp Asn Phe Glu Ser Leu Ile Asn 85 90 95 Ala Arg Thr Lys Trp Ala Asp Glu Ala Leu Arg Tyr Cys Pro Asp Ala 100 105 110 Pro Ile Val Leu Val Gly Leu Lys Lys Asp Leu Arg Gln Glu Ala His 115 120 125 Phe Lys Glu Asn Ala Thr Asp Glu Met Val Pro Ile Glu Asp Ala Lys 130 135 140 Gln Val Ala Arg Ala Ile Gly Ala Lys Lys Tyr Met Glu Cys Ser Ala Page 428 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 Leu Thr Gly Glu Gly Val Asp Asp Val Phe Glu Val Ala Thr Arg Thr 165 170 175 Ser Leu Leu Met Lys Lys Glu Pro Gly Ala Asn Cys Cys Ile Ile Leu 180 185 190 <210> 287 <211> 792 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(792) <400> 287 atg atc gct acc tcc aga gcc gta aac atg aat aaa gaa tca aaa cac 48 Met Ile Ala Thr Ser Arg Ala Val Asn Met Asn Lys Glu Ser Lys His 1 5 10 15 aag aag gct gtt gcc aaa cca tgc aga gag aga caa act tca gtt aca 96 Lys Lys Ala Val Ala Lys Pro Cys Arg Glu Arg Gln Thr Ser Val Thr 20 25 30 aga gcc atg aga cca gct gta gca cgt gat cct cgc aga ctt tcg acg 144 Arg Ala Met Arg Pro Ala Val Ala Arg Asp Pro Arg Arg Leu Ser Thr 35 40 45 tcg tcg tct cct tct tcg tca cca atg tca gca cag aga agg ctt tcg 192 Ser Ser Ser Pro Ser Ser Ser Pro Met Ser Ala Gln Arg Arg Leu Ser 50 55 60 agg gaa gaa ata ata aac gaa atg gaa aag gag caa gac gct att gta 240 Arg Glu Glu Ile Ile Asn Glu Met Glu Lys Glu Gln Asp Ala Ile Val 65 70 75 80 gta aga ctt cta cgg gaa att gaa act tta aaa gaa gaa aac tct agg 288 Val Arg Leu Leu Arg Glu Ile Glu Thr Leu Lys Glu Glu Asn Ser Arg 85 90 95 tta aaa aat caa ctg cac cat ccg gtc ccg gct aga agg tcg tct cca 336 Leu Lys Asn Gln Leu His His Pro Val Pro Ala Arg Arg Ser Ser Pro 100 105 110 ttt ttc gaa ggc gag tct gcc atc cta gat gat gat gac tgc aat tat 384 Phe Phe Glu Gly Glu Ser Ala Ile Leu Asp Asp Asp Asp Cys Asn Tyr 115 120 125 ggt tac acc ctc gac act cca aag cta aag ctc aca gat ggt gca tcc 432 Gly Tyr Thr Leu Asp Thr Pro Lys Leu Lys Leu Thr Asp Gly Ala Ser 130 135 140 aga cac acc gta ctt ccc tta aca ccc aag gac tcc atg acc cac att 480 Arg His Thr Val Leu Pro Leu Thr Pro Lys Asp Ser Met Thr His Ile 145 150 155 160 tcc cat tcc gcc aga agg tca agc cgg aac gct tcc ata tct aac gga 528 Ser His Ser Ala Arg Arg Ser Ser Arg Asn Ala Ser Ile Ser Asn Gly 165 170 175 aca agc atc tca gac acg att ttc ccc att gag act aaa atc cac tca 576 Thr Ser Ile Ser Asp Thr Ile Phe Pro Ile Glu Thr Lys Ile His Ser Page 429 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 180 185 190 gca cca aca aca aac aga aac ctt ccc tcc gcc gat ctt cca cat cac 624 Ala Pro Thr Thr Asn Arg Asn Leu Pro Ser Ala Asp Leu Pro His His 195 200 205 act ctt ctt cca cgt tct cta agc ggc att tcg tct agc gat tta acc 672 Thr Leu Leu Pro Arg Ser Leu Ser Gly Ile Ser Ser Ser Asp Leu Thr 210 215 220 gaa tcc ggt gct ctt ctt cat gac agg aga agg cgt tct tcc aat tac 720 Glu Ser Gly Ala Leu Leu His Asp Arg Arg Arg Arg Ser Ser Asn Tyr 225 230 235 240 agt ctc gat ggc tca aac tct tta aag gct gat ctc atg gca aag aga 768 Ser Leu Asp Gly Ser Asn Ser Leu Lys Ala Asp Leu Met Ala Lys Arg 245 250 255 ttc caa act ggt tca ttg aaa tag 792 Phe Gln Thr Gly Ser Leu Lys 260 <210> 288 <211> 263 <212> PRT <213> Saccharomyces cerevisiae <400> 288 Met Ile Ala Thr Ser Arg Ala Val Asn Met Asn Lys Glu Ser Lys His 1 5 10 15 Lys Lys Ala Val Ala Lys Pro Cys Arg Glu Arg Gln Thr Ser Val Thr 20 25 30 Arg Ala Met Arg Pro Ala Val Ala Arg Asp Pro Arg Arg Leu Ser Thr 35 40 45 Ser Ser Ser Pro Ser Ser Ser Pro Met Ser Ala Gln Arg Arg Leu Ser 50 55 60 Arg Glu Glu Ile Ile Asn Glu Met Glu Lys Glu Gln Asp Ala Ile Val 65 70 75 80 Val Arg Leu Leu Arg Glu Ile Glu Thr Leu Lys Glu Glu Asn Ser Arg 85 90 95 Leu Lys Asn Gln Leu His His Pro Val Pro Ala Arg Arg Ser Ser Pro 100 105 110 Phe Phe Glu Gly Glu Ser Ala Ile Leu Asp Asp Asp Asp Cys Asn Tyr 115 120 125 Gly Tyr Thr Leu Asp Thr Pro Lys Leu Lys Leu Thr Asp Gly Ala Ser 130 135 140 Arg His Thr Val Leu Pro Leu Thr Pro Lys Asp Ser Met Thr His Ile 145 150 155 160 Page 430 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser His Ser Ala Arg Arg Ser Ser Arg Asn Ala Ser Ile Ser Asn Gly 165 170 175 Thr Ser Ile Ser Asp Thr Ile Phe Pro Ile Glu Thr Lys Ile His Ser 180 185 190 Ala Pro Thr Thr Asn Arg Asn Leu Pro Ser Ala Asp Leu Pro His His 195 200 205 Thr Leu Leu Pro Arg Ser Leu Ser Gly Ile Ser Ser Ser Asp Leu Thr 210 215 220 Glu Ser Gly Ala Leu Leu His Asp Arg Arg Arg Arg Ser Ser Asn Tyr 225 230 235 240 Ser Leu Asp Gly Ser Asn Ser Leu Lys Ala Asp Leu Met Ala Lys Arg 245 250 255 Phe Gln Thr Gly Ser Leu Lys 260 <210> 289 <211> 576 <212> DNA <213> Saccharomyces cerevisiae <220> <221> CDS <222> (1)..(576) <400> 289 atg gcc tcc tca agt agc acg cta ccg ctt cat atg tat att aga ccc 48 Met Ala Ser Ser Ser Ser Thr Leu Pro Leu His Met Tyr Ile Arg Pro 1 5 10 15 tta atc att gaa gat tta aag cag att ttg aac ttg gaa agc caa ggt 96 Leu Ile Ile Glu Asp Leu Lys Gln Ile Leu Asn Leu Glu Ser Gln Gly 20 25 30 ttc cca cca aac gaa aga gct tca gaa gaa att atc agc ttt cgt ttg 144 Phe Pro Pro Asn Glu Arg Ala Ser Glu Glu Ile Ile Ser Phe Arg Leu 35 40 45 atc aat tgt cca gag cta tgt tca ggt ctt ttc atc aga gag atc gag 192 Ile Asn Cys Pro Glu Leu Cys Ser Gly Leu Phe Ile Arg Glu Ile Glu 50 55 60 ggc aaa gaa gtt aaa aag gag aca cta att ggt cat att atg ggt act 240 Gly Lys Glu Val Lys Lys Glu Thr Leu Ile Gly His Ile Met Gly Thr 65 70 75 80 aag ata cct cat gaa tac att act atc gaa agc atg ggc aaa tta caa 288 Lys Ile Pro His Glu Tyr Ile Thr Ile Glu Ser Met Gly Lys Leu Gln 85 90 95 gtg gaa tcg agt aat cat att ggt att cac tct gta gta atc aag cca 336 Val Glu Ser Ser Asn His Ile Gly Ile His Ser Val Val Ile Lys Pro 100 105 110 Page 431 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa tac cag aaa aaa aac ctg gct act tta ctt tta act gac tac att 384 Glu Tyr Gln Lys Lys Asn Leu Ala Thr Leu Leu Leu Thr Asp Tyr Ile 115 120 125 cag aaa ttg agt aat cag gaa att ggt aac aaa att gtc ctt att gct 432 Gln Lys Leu Ser Asn Gln Glu Ile Gly Asn Lys Ile Val Leu Ile Ala 130 135 140 cac gag cca ttg ata cca ttt tat gaa aga gtt ggt ttc aag atc att 480 His Glu Pro Leu Ile Pro Phe Tyr Glu Arg Val Gly Phe Lys Ile Ile 145 150 155 160 gct gag aac acc aat gtt gct aag gac aaa aac ttc gca gaa cag aaa 528 Ala Glu Asn Thr Asn Val Ala Lys Asp Lys Asn Phe Ala Glu Gln Lys 165 170 175 tgg atc gat atg gag aga gaa cta att aag gaa gaa tac gac aac tag 576 Trp Ile Asp Met Glu Arg Glu Leu Ile Lys Glu Glu Tyr Asp Asn 180 185 190 <210> 290 <211> 191 <212> PRT <213> Saccharomyces cerevisiae <400> 290 Met Ala Ser Ser Ser Ser Thr Leu Pro Leu His Met Tyr Ile Arg Pro 1 5 10 15 Leu Ile Ile Glu Asp Leu Lys Gln Ile Leu Asn Leu Glu Ser Gln Gly 20 25 30 Phe Pro Pro Asn Glu Arg Ala Ser Glu Glu Ile Ile Ser Phe Arg Leu 35 40 45 Ile Asn Cys Pro Glu Leu Cys Ser Gly Leu Phe Ile Arg Glu Ile Glu 50 55 60 Gly Lys Glu Val Lys Lys Glu Thr Leu Ile Gly His Ile Met Gly Thr 65 70 75 80 Lys Ile Pro His Glu Tyr Ile Thr Ile Glu Ser Met Gly Lys Leu Gln 85 90 95 Val Glu Ser Ser Asn His Ile Gly Ile His Ser Val Val Ile Lys Pro 100 105 110 Glu Tyr Gln Lys Lys Asn Leu Ala Thr Leu Leu Leu Thr Asp Tyr Ile 115 120 125 Gln Lys Leu Ser Asn Gln Glu Ile Gly Asn Lys Ile Val Leu Ile Ala 130 135 140 His Glu Pro Leu Ile Pro Phe Tyr Glu Arg Val Gly Phe Lys Ile Ile 145 150 155 160 Page 432 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Glu Asn Thr Asn Val Ala Lys Asp Lys Asn Phe Ala Glu Gln Lys 165 170 175 Trp Ile Asp Met Glu Arg Glu Leu Ile Lys Glu Glu Tyr Asp Asn 180 185 190 <210> 291 <211> 789 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(789) <400> 291 atg gcc gtc ggg aag aac aag cga atc tcc aaa gga aga aag gga ggc 48 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Gly 1 5 10 15 aag aag aag att gtt gat cct ttc tcc aag aag gat tgg tat gac atc 96 Lys Lys Lys Ile Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 aag gct ccc tct aac ttc act cac aga aat gtc gga aag aca ctt gtt 144 Lys Ala Pro Ser Asn Phe Thr His Arg Asn Val Gly Lys Thr Leu Val 35 40 45 tct aga act cag ggt acc aag att gca tca gag ggt ttg aaa cac aga 192 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 gtt ttc gag gtg tct ctt gct gat ctc caa ggt gat gag gat aat gct 240 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp Asn Ala 65 70 75 80 tac agg aag atc cgt ctc aga gct gaa gat gtc cag gga agg aat gtc 288 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 ttg acc cag ttc tgg gga atg gac ttc acc act gat aaa ctc aga tcc 336 Leu Thr Gln Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 ttg gtg aaa aag tgg cag act ttg att gag tgt cac gtt gat gtt aaa 384 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Cys His Val Asp Val Lys 115 120 125 acc act gac aac ttc act ctg agg ctt ttc tgc att gct ttc acc aag 432 Thr Thr Asp Asn Phe Thr Leu Arg Leu Phe Cys Ile Ala Phe Thr Lys 130 135 140 aga cgt gct aac caa gtc aag aga act tgc tac gct caa tcc agc caa 480 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 atc cgt gag att cgc agc aag atg agg gag ata atg atc aag gaa gct 528 Ile Arg Glu Ile Arg Ser Lys Met Arg Glu Ile Met Ile Lys Glu Ala 165 170 175 tcc tct tct gac ctc aag gag ctt gtt gcc aag ttt att cca gaa tct 576 Ser Ser Ser Asp Leu Lys Glu Leu Val Ala Lys Phe Ile Pro Glu Ser 180 185 190 att ggg aaa gag att gag aag gca act cag gga atc tac cct ctt caa 624 Ile Gly Lys Glu Ile Glu Lys Ala Thr Gln Gly Ile Tyr Pro Leu Gln 195 200 205 aat gtt ttc atc cgt aaa gtc aag atc ctc aag gct ccc aaa ttc gac 672 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 ctt gga aag ctc atg gag gtt cac gga gac tac aca gca gag gat gtt 720 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Thr Ala Glu Asp Val 225 230 235 240 ggt gtg aag gtt gac agg cct gct gat gag aca gtg gtc gaa gaa cct 768 Gly Val Lys Val Asp Arg Pro Ala Asp Glu Thr Val Val Glu Glu Pro 245 250 255 act gag atc att gga gct taa 789 Page 433 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Glu Ile Ile Gly Ala 260 <210> 292 <211> 262 <212> PRT <213> Brassica napus <400> 292 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Gly 1 5 10 15 Lys Lys Lys Ile Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 Lys Ala Pro Ser Asn Phe Thr His Arg Asn Val Gly Lys Thr Leu Val 35 40 45 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp Asn Ala 65 70 75 80 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 Leu Thr Gln Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Cys His Val Asp Val Lys 115 120 125 Thr Thr Asp Asn Phe Thr Leu Arg Leu Phe Cys Ile Ala Phe Thr Lys 130 135 140 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 Ile Arg Glu Ile Arg Ser Lys Met Arg Glu Ile Met Ile Lys Glu Ala 165 170 175 Ser Ser Ser Asp Leu Lys Glu Leu Val Ala Lys Phe Ile Pro Glu Ser 180 185 190 Ile Gly Lys Glu Ile Glu Lys Ala Thr Gln Gly Ile Tyr Pro Leu Gln 195 200 205 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Thr Ala Glu Asp Val 225 230 235 240 Gly Val Lys Val Asp Arg Pro Ala Asp Glu Thr Val Val Glu Glu Pro 245 250 255 Thr Glu Ile Ile Gly Ala 260 <210> 293 <211> 594 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(594) <400> 293 atg agc gca tcg agg ttc ata aag tgt gtg acc gtt ggt gac gga gct 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtg ggt aaa aca tgt ctc ctc att tct tac acc agc aac act ttc cct 96 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gat tat gtt ccg act gtt ttt gat aac ttc agc gct aat gtg gtt 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtt aac gga gcc act gtc aac ctt ggc ttg tgg gat acc gct ggg cag 192 Val Asn Gly Ala Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gag gat tat aac agg tta aga cca ttg agt tac cgc ggt gct gat gtt 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val Page 434 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 65 70 75 80 ttc atc tta gcc ttc tcc ctc atc agt aag gct agt tat gag aat gtc 288 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Val 85 90 95 tcc aag aag tgg atc cct gag ctg act cac tat gcc cct ggt gtc cca 336 Ser Lys Lys Trp Ile Pro Glu Leu Thr His Tyr Ala Pro Gly Val Pro 100 105 110 att gtt ctt gtt ggt acc aaa cta gat ctt agg gat gac aaa cag ttc 384 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttc gtt gac cac cct ggt gct gta cct att acc act gct cag gga gag 432 Phe Val Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 gaa ctg atg aag cta att gga gct cct tcg tac atc gag tgc agt tca 480 Glu Leu Met Lys Leu Ile Gly Ala Pro Ser Tyr Ile Glu Cys Ser Ser 145 150 155 160 aaa tca cag gag aac gtg aag ggg gtg ttt gat gca gcg att aga gtg 528 Lys Ser Gln Glu Asn Val Lys Gly Val Phe Asp Ala Ala Ile Arg Val 165 170 175 gta ctt caa cct cca aag cag aag aaa aag aag ggc aaa gta caa aag 576 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Gly Lys Val Gln Lys 180 185 190 gcc tgc tcc att ttg taa 594 Ala Cys Ser Ile Leu 195 <210> 294 <211> 197 <212> PRT <213> Brassica napus <400> 294 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asn Gly Ala Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Val 85 90 95 Ser Lys Lys Trp Ile Pro Glu Leu Thr His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Val Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Met Lys Leu Ile Gly Ala Pro Ser Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Ser Gln Glu Asn Val Lys Gly Val Phe Asp Ala Ala Ile Arg Val 165 170 175 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Gly Lys Val Gln Lys 180 185 190 Ala Cys Ser Ile Leu 195 <210> 295 <211> 450 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(450) Page 435 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 295 atg gcg gat cag ctc acc gac gat cag atc tct gag ttc aag gaa gcc 48 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 ttc agc tta ttc gac aag gat ggt gac ggt tgc att act acc aag gag 96 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 ctt gga acc gtg atg cgt tct ctc gga cag aac cca aca gaa gca gag 144 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 ctc caa gac atg atc aac gaa gtt gac gct gac ggt aac gga acc att 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 gat ttt cct gag ttc ttg aac ctc atg gct cgt aag atg aag gac acc 240 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 gac tcc gag gaa gag ctc aag gaa gcg ttc agg gtc ttc gac aag gat 288 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 cag aac ggt ttc atc tca gct gct gag ctc cgc cat gtg atg aca aac 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 tta ggt gag aag ctc aca gat gaa gag gtt gac gag atg att aag gaa 384 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Lys Glu 115 120 125 gct gat gtt gat ggt gat ggc cag att aac tat gag gag ttt gtc aag 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 gtc atg atg gct aag tga 450 Val Met Met Ala Lys 145 <210> 296 <211> 149 <212> PRT <213> Brassica napus <400> 296 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Lys Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Val Met Met Ala Lys 145 <210> 297 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) Page 436 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 297 atg gct cgt acg aag caa acc gca aga aaa tcc acc gga gga aaa gct 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccc agg aag cag ctc gcc acc aag gcg gcg agg aag tct gca ccg acc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 acc gga gga gtg aag aag cct cac cgt tac cgt ccc gga acc gtg gct 144 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 ctt cgt gag att aga aag tac cag aag agt acg gag ttg ctg atc cgt 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aaa ctc ccc ttc cag cgt ctt gtt cgc gag att gct cag gac ttt aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acg gat ctg agg ttt cag agc cac gct gtt tta gct ctt cag gag gcg 288 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 gcg gag gct tat ctt gtg ggt ctg ttc gag gac acc aat ctc tgt gct 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gct aag agg gtt acc atc atg ccc aag gat att caa ttg gcc 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 aga agg att cgt gga gaa cgt gct taa 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 298 <211> 136 <212> PRT <213> Brassica napus <400> 298 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 299 <211> 375 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(375) <400> 299 atg atc cta ttc ata tta ttg cag aac aga caa ggc aag acc cgt ctt 48 Met Ile Leu Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 gca aat tac tat gtt cct ctt gag gag tct gag aaa cac aaa gtc gaa 96 Page 437 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Asn Tyr Tyr Val Pro Leu Glu Glu Ser Glu Lys His Lys Val Glu 20 25 30 tac gag gtt cac aga ttg gtg gta aat cgc gac tcg aag ttc acc aat 144 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Ser Lys Phe Thr Asn 35 40 45 ttc gtt gag ttt aga acg cat aag gtt ata tac agg cgc tat gca ggc 192 Phe Val Glu Phe Arg Thr His Lys Val Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 ctg ttt ttc tcc ttg tgc gtt gac ata aca gac aat gag ttg gct tac 240 Leu Phe Phe Ser Leu Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 ctt gaa tgt atc tac ttg ttc gtc gag att ttg gac aat ttc ttc agc 288 Leu Glu Cys Ile Tyr Leu Phe Val Glu Ile Leu Asp Asn Phe Phe Ser 85 90 95 aat gtc tgt gag ctt aat ttg gtt ttc aac ttc cac aag caa att ctt 336 Asn Val Cys Glu Leu Asn Leu Val Phe Asn Phe His Lys Gln Ile Leu 100 105 110 caa cta agg gct tcc tgg atg att ctt gtt tgg cct tag 375 Gln Leu Arg Ala Ser Trp Met Ile Leu Val Trp Pro 115 120 <210> 300 <211> 124 <212> PRT <213> Brassica napus <400> 300 Met Ile Leu Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 Ala Asn Tyr Tyr Val Pro Leu Glu Glu Ser Glu Lys His Lys Val Glu 20 25 30 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Ser Lys Phe Thr Asn 35 40 45 Phe Val Glu Phe Arg Thr His Lys Val Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 Leu Phe Phe Ser Leu Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 Leu Glu Cys Ile Tyr Leu Phe Val Glu Ile Leu Asp Asn Phe Phe Ser 85 90 95 Asn Val Cys Glu Leu Asn Leu Val Phe Asn Phe His Lys Gln Ile Leu 100 105 110 Gln Leu Arg Ala Ser Trp Met Ile Leu Val Trp Pro 115 120 <210> 301 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 301 atg gct cgt acc aag cag acc gct cgt aag tct acc gga gga aag gcc 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccg agg aag cag ctt gct act aag gcc gct cgt aag tct gca cca acc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 acc gga gga gtc aag aag cca cat cgt tac aga cct gga act gtt gct 144 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 ctt cgt gag atc cgt aag tac cag aag agt act gag ctg ttg atc agg 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctt cct ttc cag agg ctt gtt cgt gag att gct cag gac ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Page 438 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 65 70 75 80 act gac ctg cgt ttc cag agc cat gcg gtg cta gca ctc cag gag gca 288 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 gct gaa gca tac ctt gtg gga ctc ttt gag gac act aac ctg tgc gcc 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gcc aag cgt gtg acc atc atg ccc aag gac atc cag ctc gct 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 cgc agg atc aga gga gag cgt gct taa 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 302 <211> 136 <212> PRT <213> Brassica napus <400> 302 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 303 <211> 591 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(591) <400> 303 atg agc gca tcg agg ttc ata aag tgt gtt aca gtc ggc gat ggt gcc 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtc gga aaa acc tgt atg ctg atc tct tac acc agc aac act ttc cct 96 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gac tat gtt cca act gtt ttc gac aac ttc agt gct aac gtg gtt 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtt gat ggg aac act gtg aat ctt gga ttg tgg gat aca gct ggt caa 192 Val Asp Gly Asn Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gaa gac tat aac agg tta aga cca ttg agt tac cgt ggt gca gat gtc 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc att ctt gct ttc tct ctt att agc aaa gct agc tac gag aac ata 288 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 gcc aag aag tgg att cct gag ctc agg cat tat gcc cct gga gtt cct 336 Page 439 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 atc att ctc gtg ggg aca aaa ctc gat ctt cga gat gac aag cag ttc 384 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttc ata gac cat ccc ggt gca gtg cca atc act aca aac cag gga gag 432 Phe Ile Asp His Pro Gly Ala Val Pro Ile Thr Thr Asn Gln Gly Glu 130 135 140 gaa cta aag aaa ctc ata gga tct cca gtt tac att gaa tgt agt tca 480 Glu Leu Lys Lys Leu Ile Gly Ser Pro Val Tyr Ile Glu Cys Ser Ser 145 150 155 160 aag acg cag cag aat gtc aaa gca gtc ttt gac gca gct att aaa gtg 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gtg ctt cag cca cca aaa tca aag aag aag aaa aag aac aag aat cgt 576 Val Leu Gln Pro Pro Lys Ser Lys Lys Lys Lys Lys Asn Lys Asn Arg 180 185 190 tgc gtt ttc ttg tga 591 Cys Val Phe Leu 195 <210> 304 <211> 196 <212> PRT <213> Brassica napus <400> 304 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asp Gly Asn Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Ile Asp His Pro Gly Ala Val Pro Ile Thr Thr Asn Gln Gly Glu 130 135 140 Glu Leu Lys Lys Leu Ile Gly Ser Pro Val Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Val Leu Gln Pro Pro Lys Ser Lys Lys Lys Lys Lys Asn Lys Asn Arg 180 185 190 Cys Val Phe Leu 195 <210> 305 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 305 atg gct cgc acc aag cag acg gca agg aaa tca acc gga ggc aag gcc 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 cca agg aag cag cta gca aca aaa gca gcg agg aaa tca gct cca gcc 96 Page 440 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acc gga gga gtg aag aag ccg cac aga ttc agg cca gga aca gtg gct 144 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 cta aga gag atc agg aag tac cag aag agc acc gag ctc ctg atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctc ccg ttc cag agg cta gtg aga gag atc gct cag gat ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acg gat ctc cgt ttc cag agc agc gcc gtc gcc gct ctc cag gaa gct 288 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gcc gag gct tac ctc gtc gga ctg ttt gag gat act aat ctg tgt gcg 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 atc cac gcc aag agg gtg acg atc atg cct aag gac ata cag ctc gcc 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 aga aga atc aga ggt gaa agg gct tag 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 306 <211> 136 <212> PRT <213> Brassica napus <400> 306 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 307 <211> 447 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(447) <400> 307 atg ggc aag gac ggc ctg agc gac gac cag gtg tca tcg atg aag gag 48 Met Gly Lys Asp Gly Leu Ser Asp Asp Gln Val Ser Ser Met Lys Glu 1 5 10 15 gcc ttc acg ctc ttc gac acc aac ggc gac ggc aaa atc gcc ccg acc 96 Ala Phe Thr Leu Phe Asp Thr Asn Gly Asp Gly Lys Ile Ala Pro Thr 20 25 30 gag ctc ggg atc ctc atg cga tcg ctc ggc ggg aac ccg acc caa gcc 144 Glu Leu Gly Ile Leu Met Arg Ser Leu Gly Gly Asn Pro Thr Gln Ala 35 40 45 Page 441 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cag ctg aaa tca atc acc gcc tcc gaa aac cta acc gct ccg ttc gat 192 Gln Leu Lys Ser Ile Thr Ala Ser Glu Asn Leu Thr Ala Pro Phe Asp 50 55 60 ttc gac cgg ttt ttg gat ctc atg gcg aag cac ctg aag acg gag cct 240 Phe Asp Arg Phe Leu Asp Leu Met Ala Lys His Leu Lys Thr Glu Pro 65 70 75 80 ttc gat cgc cag ctc cgc gac gcc ttc aag gtg ctc gac aag gaa ggc 288 Phe Asp Arg Gln Leu Arg Asp Ala Phe Lys Val Leu Asp Lys Glu Gly 85 90 95 act ggg ttc gtg gca gtg gcg gat ctg agg cat atc ttg aca agt atc 336 Thr Gly Phe Val Ala Val Ala Asp Leu Arg His Ile Leu Thr Ser Ile 100 105 110 ggg gag aag ctg gag cct aac gag ttt gat gag tgg atc aag gag gtg 384 Gly Glu Lys Leu Glu Pro Asn Glu Phe Asp Glu Trp Ile Lys Glu Val 115 120 125 gat gtg ggg tcc gat ggg aag atc aag tat gag gat ttc att gcc agg 432 Asp Val Gly Ser Asp Gly Lys Ile Lys Tyr Glu Asp Phe Ile Ala Arg 130 135 140 atg gtt gct aag tga 447 Met Val Ala Lys 145 <210> 308 <211> 148 <212> PRT <213> Brassica napus <400> 308 Met Gly Lys Asp Gly Leu Ser Asp Asp Gln Val Ser Ser Met Lys Glu 1 5 10 15 Ala Phe Thr Leu Phe Asp Thr Asn Gly Asp Gly Lys Ile Ala Pro Thr 20 25 30 Glu Leu Gly Ile Leu Met Arg Ser Leu Gly Gly Asn Pro Thr Gln Ala 35 40 45 Gln Leu Lys Ser Ile Thr Ala Ser Glu Asn Leu Thr Ala Pro Phe Asp 50 55 60 Phe Asp Arg Phe Leu Asp Leu Met Ala Lys His Leu Lys Thr Glu Pro 65 70 75 80 Phe Asp Arg Gln Leu Arg Asp Ala Phe Lys Val Leu Asp Lys Glu Gly 85 90 95 Thr Gly Phe Val Ala Val Ala Asp Leu Arg His Ile Leu Thr Ser Ile 100 105 110 Gly Glu Lys Leu Glu Pro Asn Glu Phe Asp Glu Trp Ile Lys Glu Val 115 120 125 Asp Val Gly Ser Asp Gly Lys Ile Lys Tyr Glu Asp Phe Ile Ala Arg 130 135 140 Met Val Ala Lys 145 <210> 309 <211> 1041 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1041) <400> 309 atg cct ccg aaa gcg aaa gcg aag gat gca ggt cca gta gag agg cct 48 Met Pro Pro Lys Ala Lys Ala Lys Asp Ala Gly Pro Val Glu Arg Pro 1 5 10 15 atc ctt ggc cgt ttc tct tct cac ctc aag atc gga atc gtt ggg tta 96 Ile Leu Gly Arg Phe Ser Ser His Leu Lys Ile Gly Ile Val Gly Leu 20 25 30 cca aac gtg gga aag tca aca ctt ttc aac aca cta acg aag ctt tca 144 Pro Asn Val Gly Lys Ser Thr Leu Phe Asn Thr Leu Thr Lys Leu Ser 35 40 45 Page 442 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atc cca gct gag aac ttc ccc ttt tgt acc att gag ccc aac gag gca 192 Ile Pro Ala Glu Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Glu Ala 50 55 60 cgc gtc aat atc ccc gat gac agg ttt gat tgg ctt tgc cag ttg tac 240 Arg Val Asn Ile Pro Asp Asp Arg Phe Asp Trp Leu Cys Gln Leu Tyr 65 70 75 80 aag ccc aag agt gag att cca gct ttc ttg gaa att cat gac att gct 288 Lys Pro Lys Ser Glu Ile Pro Ala Phe Leu Glu Ile His Asp Ile Ala 85 90 95 ggc ctt gtt aga ggc gct cat gaa ggg cag gga ctt gga aac aac ttc 336 Gly Leu Val Arg Gly Ala His Glu Gly Gln Gly Leu Gly Asn Asn Phe 100 105 110 ttg tcc cat att cgt gcc gtt gat ggg atc ttc cat gtc tta cgt gcg 384 Leu Ser His Ile Arg Ala Val Asp Gly Ile Phe His Val Leu Arg Ala 115 120 125 ttt gaa gat cct gat att att cat gtt gat gat att gtg gat cct gtt 432 Phe Glu Asp Pro Asp Ile Ile His Val Asp Asp Ile Val Asp Pro Val 130 135 140 aga gat ttg gag acc att act gaa gaa ttg cga cta aag gat att gaa 480 Arg Asp Leu Glu Thr Ile Thr Glu Glu Leu Arg Leu Lys Asp Ile Glu 145 150 155 160 ttc att aaa aag aag att gaa gat gtc gag aag agc atg aag agg agc 528 Phe Ile Lys Lys Lys Ile Glu Asp Val Glu Lys Ser Met Lys Arg Ser 165 170 175 aat gac aag gcg ctt aaa gtt gaa ctt gag ctc ttg cta aag gtg aaa 576 Asn Asp Lys Ala Leu Lys Val Glu Leu Glu Leu Leu Leu Lys Val Lys 180 185 190 gct tgg ctg gaa gaa gga aag gat gtc cgt ttt gga gac tgg aaa gca 624 Ala Trp Leu Glu Glu Gly Lys Asp Val Arg Phe Gly Asp Trp Lys Ala 195 200 205 gct gat atc gag att ttg aac act ttc caa ttg ctt tcc gca aag ccc 672 Ala Asp Ile Glu Ile Leu Asn Thr Phe Gln Leu Leu Ser Ala Lys Pro 210 215 220 gtt gtt tac ttg att aac atg aat gag aga gat tat cag agg aag aaa 720 Val Val Tyr Leu Ile Asn Met Asn Glu Arg Asp Tyr Gln Arg Lys Lys 225 230 235 240 aac aag ttc ttg cca aag att cat gct tgg gtt caa gaa cac ggt ggt 768 Asn Lys Phe Leu Pro Lys Ile His Ala Trp Val Gln Glu His Gly Gly 245 250 255 gat act atg att cct ttc agt ggt gtt ttt gaa agg act ctc gct gat 816 Asp Thr Met Ile Pro Phe Ser Gly Val Phe Glu Arg Thr Leu Ala Asp 260 265 270 atg ctc cca gac gaa gca gca aag tat tgt gag gag aac aaa cta caa 864 Met Leu Pro Asp Glu Ala Ala Lys Tyr Cys Glu Glu Asn Lys Leu Gln 275 280 285 agt gct ctt ccg agg atc atc aaa act gga ttt tca gcc att aac ctc 912 Ser Ala Leu Pro Arg Ile Ile Lys Thr Gly Phe Ser Ala Ile Asn Leu 290 295 300 ata tat ttc ttt aca gcg gga cct gat gag gtg aag tgc tgg caa ata 960 Ile Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Lys Cys Trp Gln Ile 305 310 315 320 aga cgt cag tca aag gct cct caa gct gca ggg gcc att cat act gat 1008 Arg Arg Gln Ser Lys Ala Pro Gln Ala Ala Gly Ala Ile His Thr Asp 325 330 335 ttt gag aga gga ttt att tgt gct agg tca tga 1041 Phe Glu Arg Gly Phe Ile Cys Ala Arg Ser 340 345 <210> 310 <211> 346 <212> PRT <213> Brassica napus <400> 310 Met Pro Pro Lys Ala Lys Ala Lys Asp Ala Gly Pro Val Glu Arg Pro 1 5 10 15 Ile Leu Gly Arg Phe Ser Ser His Leu Lys Ile Gly Ile Val Gly Leu 20 25 30 Page 443 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Asn Val Gly Lys Ser Thr Leu Phe Asn Thr Leu Thr Lys Leu Ser 35 40 45 Ile Pro Ala Glu Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Glu Ala 50 55 60 Arg Val Asn Ile Pro Asp Asp Arg Phe Asp Trp Leu Cys Gln Leu Tyr 65 70 75 80 Lys Pro Lys Ser Glu Ile Pro Ala Phe Leu Glu Ile His Asp Ile Ala 85 90 95 Gly Leu Val Arg Gly Ala His Glu Gly Gln Gly Leu Gly Asn Asn Phe 100 105 110 Leu Ser His Ile Arg Ala Val Asp Gly Ile Phe His Val Leu Arg Ala 115 120 125 Phe Glu Asp Pro Asp Ile Ile His Val Asp Asp Ile Val Asp Pro Val 130 135 140 Arg Asp Leu Glu Thr Ile Thr Glu Glu Leu Arg Leu Lys Asp Ile Glu 145 150 155 160 Phe Ile Lys Lys Lys Ile Glu Asp Val Glu Lys Ser Met Lys Arg Ser 165 170 175 Asn Asp Lys Ala Leu Lys Val Glu Leu Glu Leu Leu Leu Lys Val Lys 180 185 190 Ala Trp Leu Glu Glu Gly Lys Asp Val Arg Phe Gly Asp Trp Lys Ala 195 200 205 Ala Asp Ile Glu Ile Leu Asn Thr Phe Gln Leu Leu Ser Ala Lys Pro 210 215 220 Val Val Tyr Leu Ile Asn Met Asn Glu Arg Asp Tyr Gln Arg Lys Lys 225 230 235 240 Asn Lys Phe Leu Pro Lys Ile His Ala Trp Val Gln Glu His Gly Gly 245 250 255 Asp Thr Met Ile Pro Phe Ser Gly Val Phe Glu Arg Thr Leu Ala Asp 260 265 270 Met Leu Pro Asp Glu Ala Ala Lys Tyr Cys Glu Glu Asn Lys Leu Gln 275 280 285 Ser Ala Leu Pro Arg Ile Ile Lys Thr Gly Phe Ser Ala Ile Asn Leu 290 295 300 Ile Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Lys Cys Trp Gln Ile 305 310 315 320 Arg Arg Gln Ser Lys Ala Pro Gln Ala Ala Gly Ala Ile His Thr Asp 325 330 335 Phe Glu Arg Gly Phe Ile Cys Ala Arg Ser 340 345 <210> 311 <211> 762 <212> DNA <213> Brassica napus <400> 311 atggttggac caggaagacc tcaaatcgtc ctcttcggtt catcaatcgt tcaatacagc 60 ttcagcgatg gtggatgggg agccactctc gctaacatct actctcgcac ggctgacgta 120 atccttcgtg ggtatgctgg ttggaactcc agatctgcct tgaaggtgtt aaaccaagtg 180 ttcccaaagg atgctgttat acaaccttct ttggtgatag tctatttcgg agggaatgat 240 tcaatgcctc ctcatccatc agggcaagga cctcatgttc ctctctctga attcactgag 300 aacatgagga agatcggaga gcatcttttg agcctctcgg acaagacccg tgtcattttt 360 ctcactcccc caccaatgaa cgagagacaa atccaactag tgtttggaga tgcaatgaga 420 ggccggagta acgagctgtg tcgtccatac gcagaagcgt tgttgaatct atgcagagag 480 atcaatgtga aaggtatcga tctttggaac gcaatacagc aacaagatga ttggttacac 540 acttgcttca ctgacggtat ccatttcacg gccaaggcga gcgagattgt ggtgaaggag 600 atattgaaag tagtgagaga agctgattgg aaaccgagtc ttgacaggaa gtcattaccg 660 gttgagtttc catttgattc tggtctacca aactccccaa gacatagtga tctagaatta 720 actagaaaca agaagttgga gcctcgtatg gcccgattgt aa 762 <210> 312 <211> 733 <212> DNA <213> Brassica napus <220> <221> CDS Page 444 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(594) <400> 312 atg agc gca tct cgg ttc ata aag tgc gtg acg gtc ggt gac gga gca 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtg ggc aaa aca tgt ctc ctc atc tct tac acc agc aac act ttc cct 96 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gat tat gtg ccc act gtt ttc gat aac ttt agc gct aac gtt gtt 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtt aac gga gcc act gtc aac tta gga ctc tgg gat aca gca ggg cag 192 Val Asn Gly Ala Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gag gat tat aac aga ttg aga ccc ttg agt tac cgc ggt gct gac gtt 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc atc tta gcc ttc tct ctt atc agt aag gct agt tat gag aat gtc 288 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Val 85 90 95 tcc aag aag tgg atc cct gag ctg acc cac tat gcc cct ggt gtc cct 336 Ser Lys Lys Trp Ile Pro Glu Leu Thr His Tyr Ala Pro Gly Val Pro 100 105 110 att gtt ctt gtt gga acc aaa cta gat ctt agg gat gac aaa cag ttc 384 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttc gtt gac cac cct ggt gct gta cct att acc act gct cag ggc gag 432 Phe Val Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 gaa cta atg aag cta att gga gct cct tcg tac atc gag tgc agc tca 480 Glu Leu Met Lys Leu Ile Gly Ala Pro Ser Tyr Ile Glu Cys Ser Ser 145 150 155 160 aaa tca cag gag aac gtg aag ggg gtg ttt gat gca gcg atc aga gtg 528 Lys Ser Gln Glu Asn Val Lys Gly Val Phe Asp Ala Ala Ile Arg Val 165 170 175 gta ctt caa cct cca aag cag aag aaa aag aag agc aaa gct caa aag 576 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Ser Lys Ala Gln Lys 180 185 190 gcc tgc tcc att ttg tgatttctct acgctcatct ctcttccact ctctagtgaa 631 Ala Cys Ser Ile Leu 195 ggcttaagaa gaagaaacac tttagccttt aagatttggt tcagagttcg ttgtgataag 691 cctcgcttaa tccttagaaa cgattacttc tggttttact ga 733 <210> 313 <211> 197 <212> PRT <213> Brassica napus <400> 313 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asn Gly Ala Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Val 85 90 95 Ser Lys Lys Trp Ile Pro Glu Leu Thr His Tyr Ala Pro Gly Val Pro Page 445 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 100 105 110 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Val Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Met Lys Leu Ile Gly Ala Pro Ser Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Ser Gln Glu Asn Val Lys Gly Val Phe Asp Ala Ala Ile Arg Val 165 170 175 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Ser Lys Ala Gln Lys 180 185 190 Ala Cys Ser Ile Leu 195 <210> 314 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 314 atg gct cgt acc aag caa acc gct aga aaa tcc acc gga gga aag gct 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccg agg aag cag ctg gcg acg aaa gcg gcg agg aag tcg gct ccg gcc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acg gga gga gtg aag aag ccg cac aga ttc cgt ccc gga acc gtc gcc 144 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 ctt cgt gag atc agg aag tac cag aag agc acc gag ctt ctc atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctt ccc ttc cag cgt ctg gtc cgt gag atc gct cag gac ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 atg gat ctg agg ttc cag agc agc gcc gtc gcg gct ttg caa gag gct 288 Met Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gct gag gct tac ctt gtt ggt ttg ttc gaa gac acc aat ctc tgc gcg 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gcc aaa aga gtg acg atc atg ccc aag gat atc cag ctc gct 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 agg aga atc cgt ggt gaa aga gct tga 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 315 <211> 136 <212> PRT <213> Brassica napus <400> 315 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Page 446 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 316 <211> 606 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(606) <400> 316 atg agc aca gcg aga ttc atc aag tgt gtg acg gtc gga gat gga gct 48 Met Ser Thr Ala Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtg ggg aag act tgt atg ctg att tca tat acc agc aat act ttt cct 96 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gat tac gtt ccg aca gtt ttt gac aat ttc agt gcg aat gtg gtg 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtc gat gga agt act gtc aac ctc ggc ctg tgg gat act gct ggg cag 192 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gaa gat tat aac agg ctt cgg cct ttg agt tac aga gga gca gat gtg 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttt tta ttg gca ttt tcc cta att agc aag gcc agt tac gag aac att 288 Phe Leu Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 tac aaa aag tgg ctt ccg gag ctg aaa cat tat gcg cct agc atc ccc 336 Tyr Lys Lys Trp Leu Pro Glu Leu Lys His Tyr Ala Pro Ser Ile Pro 100 105 110 att gta ctc gtc gga acc aag tta gat ttg agg gat gac aaa cag ttc 384 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttg aaa gat cat cca gga gca gct tca ata aca act gcc cag gga gag 432 Leu Lys Asp His Pro Gly Ala Ala Ser Ile Thr Thr Ala Gln Gly Glu 130 135 140 gaa tta aga aag atg att gga gcc atc aag tac tta gaa tgc agc tcc 480 Glu Leu Arg Lys Met Ile Gly Ala Ile Lys Tyr Leu Glu Cys Ser Ser 145 150 155 160 aaa acc cag cag aat gtg aag gca gtg ttt gat aca gcg atc cgg gta 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Thr Ala Ile Arg Val 165 170 175 gcg ttg agg cct cca aag gca aag aag aag ata aag cca ttg agg acc 576 Ala Leu Arg Pro Pro Lys Ala Lys Lys Lys Ile Lys Pro Leu Arg Thr 180 185 190 aaa aga tca aga aca tgc ttt ttc ttc taa 606 Lys Arg Ser Arg Thr Cys Phe Phe Phe 195 200 <210> 317 <211> 201 <212> PRT <213> Brassica napus <400> 317 Met Ser Thr Ala Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro Page 447 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Leu Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 Tyr Lys Lys Trp Leu Pro Glu Leu Lys His Tyr Ala Pro Ser Ile Pro 100 105 110 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Leu Lys Asp His Pro Gly Ala Ala Ser Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Arg Lys Met Ile Gly Ala Ile Lys Tyr Leu Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Thr Ala Ile Arg Val 165 170 175 Ala Leu Arg Pro Pro Lys Ala Lys Lys Lys Ile Lys Pro Leu Arg Thr 180 185 190 Lys Arg Ser Arg Thr Cys Phe Phe Phe 195 200 <210> 318 <211> 327 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(327) <400> 318 atg agt agg cca atg gaa gag gat acc aac ggg aaa acc gaa gag gag 48 Met Ser Arg Pro Met Glu Glu Asp Thr Asn Gly Lys Thr Glu Glu Glu 1 5 10 15 gag ttc aac acc gga ccc ctt tct gtt ctg atg atg agt gtt aag aac 96 Glu Phe Asn Thr Gly Pro Leu Ser Val Leu Met Met Ser Val Lys Asn 20 25 30 aac act cag gtg ttg atc aac tgc cgc aac aac agg aaa ctc ctt ggc 144 Asn Thr Gln Val Leu Ile Asn Cys Arg Asn Asn Arg Lys Leu Leu Gly 35 40 45 cgt gtt agg gct ttc gac agg cac tgc aac atg gtt ctt gaa aat gtc 192 Arg Val Arg Ala Phe Asp Arg His Cys Asn Met Val Leu Glu Asn Val 50 55 60 agg gaa atg tgg act gag gta cct aaa act ggg aaa gga aag aag aaa 240 Arg Glu Met Trp Thr Glu Val Pro Lys Thr Gly Lys Gly Lys Lys Lys 65 70 75 80 gct ctt ccc gtc aac aga gat cgc ttt atc agc aag atg ttt ctt cgt 288 Ala Leu Pro Val Asn Arg Asp Arg Phe Ile Ser Lys Met Phe Leu Arg 85 90 95 ggt gac tct gtc atc atc gtc ctt agg aat ccc aag taa 327 Gly Asp Ser Val Ile Ile Val Leu Arg Asn Pro Lys 100 105 <210> 319 <211> 108 <212> PRT <213> Brassica napus <400> 319 Met Ser Arg Pro Met Glu Glu Asp Thr Asn Gly Lys Thr Glu Glu Glu 1 5 10 15 Glu Phe Asn Thr Gly Pro Leu Ser Val Leu Met Met Ser Val Lys Asn 20 25 30 Asn Thr Gln Val Leu Ile Asn Cys Arg Asn Asn Arg Lys Leu Leu Gly 35 40 45 Page 448 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Val Arg Ala Phe Asp Arg His Cys Asn Met Val Leu Glu Asn Val 50 55 60 Arg Glu Met Trp Thr Glu Val Pro Lys Thr Gly Lys Gly Lys Lys Lys 65 70 75 80 Ala Leu Pro Val Asn Arg Asp Arg Phe Ile Ser Lys Met Phe Leu Arg 85 90 95 Gly Asp Ser Val Ile Ile Val Leu Arg Asn Pro Lys 100 105 <210> 320 <211> 636 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(636) <400> 320 atg tca gct tca gtg gct gct gca tca gta tca aca aca aca aca gca 48 Met Ser Ala Ser Val Ala Ala Ala Ser Val Ser Thr Thr Thr Thr Ala 1 5 10 15 gct aca acg ttt atc aag tgc gtc act gtt ggc gat gga gct gtg ggc 96 Ala Thr Thr Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala Val Gly 20 25 30 aaa act tgt ctt ctt atc tcc tac acc agc aac acc ttt cct act gat 144 Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro Thr Asp 35 40 45 tat gtt cct aca gtg ttc gac aac ttc agt gca aat gtt cta gtc gat 192 Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Leu Val Asp 50 55 60 ggc aaa acc gtc aat ctt ggt ctt tgg gat act gct ggt caa gaa gat 240 Gly Lys Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp 65 70 75 80 tac aat agg ctt aga cca ttg agt tac aga gga gca gat gtt ttc att 288 Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val Phe Ile 85 90 95 ctt gcc ttt tct ctt atc agc agg cct agc ttt gag aac att gct aaa 336 Leu Ala Phe Ser Leu Ile Ser Arg Pro Ser Phe Glu Asn Ile Ala Lys 100 105 110 aag tgg gtc cct gag ctg cga cat tat gcc cct aac gtg cct att gtt 384 Lys Trp Val Pro Glu Leu Arg His Tyr Ala Pro Asn Val Pro Ile Val 115 120 125 cta gtg gga act aaa tta gat cta aga gag gat aag aag ttc cca atg 432 Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Lys Lys Phe Pro Met 130 135 140 aac tat cca ggt gct tgc aca atc tca aca gaa caa ggt caa gag cta 480 Asn Tyr Pro Gly Ala Cys Thr Ile Ser Thr Glu Gln Gly Gln Glu Leu 145 150 155 160 aga aaa gag ata gga gca tta gca tat ata gag tgc agc tca aaa aca 528 Arg Lys Glu Ile Gly Ala Leu Ala Tyr Ile Glu Cys Ser Ser Lys Thr 165 170 175 caa cag aac gtg aaa gcg gtg ttt gat gca gcg ata aaa gta gtt cta 576 Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val Val Leu 180 185 190 cag cct cct aca aaa att aag aaa caa aag aga aga ttt cgt ttc tgc 624 Gln Pro Pro Thr Lys Ile Lys Lys Gln Lys Arg Arg Phe Arg Phe Cys 195 200 205 cat gct ctc tga 636 His Ala Leu 210 <210> 321 <211> 211 <212> PRT <213> Brassica napus <400> 321 Page 449 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Ser Ala Ser Val Ala Ala Ala Ser Val Ser Thr Thr Thr Thr Ala 1 5 10 15 Ala Thr Thr Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala Val Gly 20 25 30 Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro Thr Asp 35 40 45 Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Leu Val Asp 50 55 60 Gly Lys Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln Glu Asp 65 70 75 80 Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val Phe Ile 85 90 95 Leu Ala Phe Ser Leu Ile Ser Arg Pro Ser Phe Glu Asn Ile Ala Lys 100 105 110 Lys Trp Val Pro Glu Leu Arg His Tyr Ala Pro Asn Val Pro Ile Val 115 120 125 Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Lys Lys Phe Pro Met 130 135 140 Asn Tyr Pro Gly Ala Cys Thr Ile Ser Thr Glu Gln Gly Gln Glu Leu 145 150 155 160 Arg Lys Glu Ile Gly Ala Leu Ala Tyr Ile Glu Cys Ser Ser Lys Thr 165 170 175 Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val Val Leu 180 185 190 Gln Pro Pro Thr Lys Ile Lys Lys Gln Lys Arg Arg Phe Arg Phe Cys 195 200 205 His Ala Leu 210 <210> 322 <211> 297 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(297) <400> 322 atg atg aag cgt ctg gtc cca acg ttc aac cgc atc ctg gtg cag aga 48 Met Met Lys Arg Leu Val Pro Thr Phe Asn Arg Ile Leu Val Gln Arg 1 5 10 15 gtc atc cag cct gct aaa acc gag agc ggc atc ctc ctc cca gag aaa 96 Val Ile Gln Pro Ala Lys Thr Glu Ser Gly Ile Leu Leu Pro Glu Lys 20 25 30 gcc tcc tcg ttg aac tcg ggc aag gtg ata gca gtg gga cct ggt tca 144 Ala Ser Ser Leu Asn Ser Gly Lys Val Ile Ala Val Gly Pro Gly Ser 35 40 45 agg gac aaa gat ggg aaa ttg att ccg gtc tct gtc aag gaa ggc gac 192 Arg Asp Lys Asp Gly Lys Leu Ile Pro Val Ser Val Lys Glu Gly Asp 50 55 60 acc gtt ctt ctt cca gag tac ggc ggt act cag gtc aag ctc ggc gag 240 Thr Val Leu Leu Pro Glu Tyr Gly Gly Thr Gln Val Lys Leu Gly Glu 65 70 75 80 aaa gag tac cat ctc ttc cgt gat gag gac gtc ttg gga aca ttg cac 288 Lys Glu Tyr His Leu Phe Arg Asp Glu Asp Val Leu Gly Thr Leu His 85 90 95 gag gat tga 297 Glu Asp <210> 323 <211> 98 <212> PRT <213> Brassica napus <400> 323 Met Met Lys Arg Leu Val Pro Thr Phe Asn Arg Ile Leu Val Gln Arg Page 450 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 Val Ile Gln Pro Ala Lys Thr Glu Ser Gly Ile Leu Leu Pro Glu Lys 20 25 30 Ala Ser Ser Leu Asn Ser Gly Lys Val Ile Ala Val Gly Pro Gly Ser 35 40 45 Arg Asp Lys Asp Gly Lys Leu Ile Pro Val Ser Val Lys Glu Gly Asp 50 55 60 Thr Val Leu Leu Pro Glu Tyr Gly Gly Thr Gln Val Lys Leu Gly Glu 65 70 75 80 Lys Glu Tyr His Leu Phe Arg Asp Glu Asp Val Leu Gly Thr Leu His 85 90 95 Glu Asp <210> 324 <211> 1032 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1032) <400> 324 atg ggt tcg ctc aag gac ggt caa aga agg gac ttg gag gga gga gaa 48 Met Gly Ser Leu Lys Asp Gly Gln Arg Arg Asp Leu Glu Gly Gly Glu 1 5 10 15 gaa gaa tcg gag gag ccg cta tta acg gcg cag aac cag agg ttc act 96 Glu Glu Ser Glu Glu Pro Leu Leu Thr Ala Gln Asn Gln Arg Phe Thr 20 25 30 atg ttc cca att agg tac aag tcg att tgg gag atg tat aag aag gct 144 Met Phe Pro Ile Arg Tyr Lys Ser Ile Trp Glu Met Tyr Lys Lys Ala 35 40 45 gag gcc agc ttc tgg act gct gaa gaa gtt gat ctt tcg acg gat gtg 192 Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Thr Asp Val 50 55 60 cag cac tgg gaa aag ttg tcg gat tca gag aaa cat ttc atc agc cat 240 Gln His Trp Glu Lys Leu Ser Asp Ser Glu Lys His Phe Ile Ser His 65 70 75 80 gtt ctg gcc ttt ttc gcg gca tca gat ggg att gtt ttg gag aat ttg 288 Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu Asn Leu 85 90 95 gcc gct agg ttc ttg aat gat gtc caa gtc cct gag gct cgt gct ttc 336 Ala Ala Arg Phe Leu Asn Asp Val Gln Val Pro Glu Ala Arg Ala Phe 100 105 110 tat ggg ttt caa att gcc atg gag aac att cat tct gag atg tac agc 384 Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His Ser Glu Met Tyr Ser 115 120 125 caa ctt ctg gag acg ttt ata aag gat tcg cag gag aag gat aga ttg 432 Gln Leu Leu Glu Thr Phe Ile Lys Asp Ser Gln Glu Lys Asp Arg Leu 130 135 140 ttc aat gct att gag acc att ccc tgc att tcc aac aag gct aaa tgg 480 Phe Asn Ala Ile Glu Thr Ile Pro Cys Ile Ser Asn Lys Ala Lys Trp 145 150 155 160 tgt tta gat tgg att caa agt cct atg tct ttt gct gtg agg ctt gtt 528 Cys Leu Asp Trp Ile Gln Ser Pro Met Ser Phe Ala Val Arg Leu Val 165 170 175 gct ttt gca tgc gtc gaa gga atc ttc ttc tcc gga agc ttc tgt gcc 576 Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe Cys Ala 180 185 190 atc ttc tgg ctg aag aag aga ggt ctt atg cct ggt ttg act ttc tca 624 Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr Phe Ser 195 200 205 aac gag ctt ata tcg aga gac gag ggt ctc cac tgt gac ttt gca tgt 672 Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe Ala Cys 210 215 220 ctc ttg tac agt ttg ctt cag aag cag ctt cct gtg gag aaa gtt tat 720 Leu Leu Tyr Ser Leu Leu Gln Lys Gln Leu Pro Val Glu Lys Val Tyr Page 451 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 225 230 235 240 cag att gtt cat gag gca gtg gaa att gag aca gag ttt gtc tgc aag 768 Gln Ile Val His Glu Ala Val Glu Ile Glu Thr Glu Phe Val Cys Lys 245 250 255 gcc ctt tca tgc gat ctg att gga atg aac tca aac ctc atg agt cag 816 Ala Leu Ser Cys Asp Leu Ile Gly Met Asn Ser Asn Leu Met Ser Gln 260 265 270 tac ata caa ttt gtc gca gac cgt ctt ctg gtt aca ttg gga tgt gaa 864 Tyr Ile Gln Phe Val Ala Asp Arg Leu Leu Val Thr Leu Gly Cys Glu 275 280 285 agg aga tac aaa gca gat aat cca ttt gac tgg atg gag ttc ata tct 912 Arg Arg Tyr Lys Ala Asp Asn Pro Phe Asp Trp Met Glu Phe Ile Ser 290 295 300 ctc cga ggg aag aca aac ttc ttt gag aag aga gtg gga gag tat cag 960 Leu Arg Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu Tyr Gln 305 310 315 320 aaa gca tct gtt atg tca agc ctc caa gaa ggt aat aag aac tac gaa 1008 Lys Ala Ser Val Met Ser Ser Leu Gln Glu Gly Asn Lys Asn Tyr Glu 325 330 335 ttc aag att gat gag gac ttt tga 1032 Phe Lys Ile Asp Glu Asp Phe 340 <210> 325 <211> 343 <212> PRT <213> Brassica napus <400> 325 Met Gly Ser Leu Lys Asp Gly Gln Arg Arg Asp Leu Glu Gly Gly Glu 1 5 10 15 Glu Glu Ser Glu Glu Pro Leu Leu Thr Ala Gln Asn Gln Arg Phe Thr 20 25 30 Met Phe Pro Ile Arg Tyr Lys Ser Ile Trp Glu Met Tyr Lys Lys Ala 35 40 45 Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Thr Asp Val 50 55 60 Gln His Trp Glu Lys Leu Ser Asp Ser Glu Lys His Phe Ile Ser His 65 70 75 80 Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu Asn Leu 85 90 95 Ala Ala Arg Phe Leu Asn Asp Val Gln Val Pro Glu Ala Arg Ala Phe 100 105 110 Tyr Gly Phe Gln Ile Ala Met Glu Asn Ile His Ser Glu Met Tyr Ser 115 120 125 Gln Leu Leu Glu Thr Phe Ile Lys Asp Ser Gln Glu Lys Asp Arg Leu 130 135 140 Phe Asn Ala Ile Glu Thr Ile Pro Cys Ile Ser Asn Lys Ala Lys Trp 145 150 155 160 Cys Leu Asp Trp Ile Gln Ser Pro Met Ser Phe Ala Val Arg Leu Val 165 170 175 Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe Cys Ala 180 185 190 Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr Phe Ser 195 200 205 Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe Ala Cys 210 215 220 Leu Leu Tyr Ser Leu Leu Gln Lys Gln Leu Pro Val Glu Lys Val Tyr 225 230 235 240 Gln Ile Val His Glu Ala Val Glu Ile Glu Thr Glu Phe Val Cys Lys 245 250 255 Ala Leu Ser Cys Asp Leu Ile Gly Met Asn Ser Asn Leu Met Ser Gln 260 265 270 Tyr Ile Gln Phe Val Ala Asp Arg Leu Leu Val Thr Leu Gly Cys Glu 275 280 285 Arg Arg Tyr Lys Ala Asp Asn Pro Phe Asp Trp Met Glu Phe Ile Ser 290 295 300 Leu Arg Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu Tyr Gln Page 452 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 305 310 315 320 Lys Ala Ser Val Met Ser Ser Leu Gln Glu Gly Asn Lys Asn Tyr Glu 325 330 335 Phe Lys Ile Asp Glu Asp Phe 340 <210> 326 <211> 789 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(789) <400> 326 atg gcc gtc ggg aag aac aag aga atc tct aaa gga aga aag gga ggg 48 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Gly 1 5 10 15 aag aag aag att gtt gat cct ttc tcc aag aag gat tgg tat gac atc 96 Lys Lys Lys Ile Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 aag gct ccc tct aac ttc aat aac aga aat gtc gga aag aca ctt gtt 144 Lys Ala Pro Ser Asn Phe Asn Asn Arg Asn Val Gly Lys Thr Leu Val 35 40 45 tct aga act cag ggt acc aag att gca tca gag ggt ttg aaa cac aga 192 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 gtt ttc gag gtt tct ctt gct gat ctc caa ggt gat gag gat cac gct 240 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ala 65 70 75 80 tac agg aag atc cgt ctc aga gct gaa gat gtc cag ggc agg aat gtg 288 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 ttg acc cag ttc tgg ggt atg gac ttc aca acc gac aag ctc agg tcc 336 Leu Thr Gln Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 ttg gtt aaa aag tgg cag act ttg atc gag tct cat gtc gat gtc aaa 384 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ser His Val Asp Val Lys 115 120 125 acc act gat aac tac aca ctg agg ctt ttc tgc atc gcc ttc acc aag 432 Thr Thr Asp Asn Tyr Thr Leu Arg Leu Phe Cys Ile Ala Phe Thr Lys 130 135 140 aga cgt gct aac caa gtc aag aga act tgc tat gct caa tcc agc caa 480 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 atc cgt cag att cgc agc aag atg agg gag atc atg atc aag gaa gct 528 Ile Arg Gln Ile Arg Ser Lys Met Arg Glu Ile Met Ile Lys Glu Ala 165 170 175 tcg tct tgt gac ctc aag gag ctt gtt gcc aag ttt att ccc gaa gct 576 Ser Ser Cys Asp Leu Lys Glu Leu Val Ala Lys Phe Ile Pro Glu Ala 180 185 190 att ggg aag gat att gag aag gcg act cag ggc atc tac cct ctt cag 624 Ile Gly Lys Asp Ile Glu Lys Ala Thr Gln Gly Ile Tyr Pro Leu Gln 195 200 205 aat gtt ttc atc cgt aaa gtc aag atc ctc aag gct ccc aag ttc gac 672 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 ctc gga aag ctc atg gag gtt cac gga gac tac aca gca gag gat gtt 720 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Thr Ala Glu Asp Val 225 230 235 240 ggt gtc aag gtt gac agg ccg gcc gat gag act gct gcc gag gaa cct 768 Gly Val Lys Val Asp Arg Pro Ala Asp Glu Thr Ala Ala Glu Glu Pro 245 250 255 act gag atc att gga gct taa 789 Thr Glu Ile Ile Gly Ala 260 Page 453 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 327 <211> 262 <212> PRT <213> Brassica napus <400> 327 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Gly 1 5 10 15 Lys Lys Lys Ile Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 Lys Ala Pro Ser Asn Phe Asn Asn Arg Asn Val Gly Lys Thr Leu Val 35 40 45 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ala 65 70 75 80 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 Leu Thr Gln Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ser His Val Asp Val Lys 115 120 125 Thr Thr Asp Asn Tyr Thr Leu Arg Leu Phe Cys Ile Ala Phe Thr Lys 130 135 140 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 Ile Arg Gln Ile Arg Ser Lys Met Arg Glu Ile Met Ile Lys Glu Ala 165 170 175 Ser Ser Cys Asp Leu Lys Glu Leu Val Ala Lys Phe Ile Pro Glu Ala 180 185 190 Ile Gly Lys Asp Ile Glu Lys Ala Thr Gln Gly Ile Tyr Pro Leu Gln 195 200 205 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Thr Ala Glu Asp Val 225 230 235 240 Gly Val Lys Val Asp Arg Pro Ala Asp Glu Thr Ala Ala Glu Glu Pro 245 250 255 Thr Glu Ile Ile Gly Ala 260 <210> 328 <211> 840 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(840) <400> 328 atg tcg tcc ggt tta atc gga aga tta gtc gga acc aaa ccg tcg cga 48 Met Ser Ser Gly Leu Ile Gly Arg Leu Val Gly Thr Lys Pro Ser Arg 1 5 10 15 tta acc acc gca gca agg ttg atc ccg tcg cga tgc aca gcc tcc gta 96 Leu Thr Thr Ala Ala Arg Leu Ile Pro Ser Arg Cys Thr Ala Ser Val 20 25 30 acc gaa ccg gaa cca aaa gcg tcc tct ggc ggc gga aaa cca tcg aac 144 Thr Glu Pro Glu Pro Lys Ala Ser Ser Gly Gly Gly Lys Pro Ser Asn 35 40 45 ttc aaa act ttc cag atc tac cga tgg aac ccc gac aac cct agc aag 192 Phe Lys Thr Phe Gln Ile Tyr Arg Trp Asn Pro Asp Asn Pro Ser Lys 50 55 60 cct gag ctc caa gac tac aag atc gac ctc aaa gac tgc ggc ccc atg 240 Pro Glu Leu Gln Asp Tyr Lys Ile Asp Leu Lys Asp Cys Gly Pro Met 65 70 75 80 gtt ctc gac gcc ttg atc aaa atc aag aac gag atg gat ccg tct ctc 288 Val Leu Asp Ala Leu Ile Lys Ile Lys Asn Glu Met Asp Pro Ser Leu Page 454 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 acc ttc cgc cgc tcg tgc cga gaa ggg atc tgc ggc tcg tgc gcg atg 336 Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser Cys Ala Met 100 105 110 aac atc gac ggg tgc aac ggg ctc gcg tgt ctg acg aag atc gag gag 384 Asn Ile Asp Gly Cys Asn Gly Leu Ala Cys Leu Thr Lys Ile Glu Glu 115 120 125 gga gcc aag gag acg acg atc act ccc ttg cct cac atg ttc gtg atc 432 Gly Ala Lys Glu Thr Thr Ile Thr Pro Leu Pro His Met Phe Val Ile 130 135 140 aag gat ctg gtg gtg gac atg act aac ttt tat aat cag tac aag agt 480 Lys Asp Leu Val Val Asp Met Thr Asn Phe Tyr Asn Gln Tyr Lys Ser 145 150 155 160 att gag ccg tgg ctg aag agg aag aac cct ccg tct gag cct ggg aag 528 Ile Glu Pro Trp Leu Lys Arg Lys Asn Pro Pro Ser Glu Pro Gly Lys 165 170 175 gag att ctg cag agt aag aag gat agg gct aag ctt gat ggg atg tat 576 Glu Ile Leu Gln Ser Lys Lys Asp Arg Ala Lys Leu Asp Gly Met Tyr 180 185 190 gag tgt att ctc tgc gct tgt tgt agc acg tct tgt cct agt tac tgg 624 Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Tyr Trp 195 200 205 tgg aac cct gag tct tac ctt ggc cct gcc gct ttg cta cat gcc aat 672 Trp Asn Pro Glu Ser Tyr Leu Gly Pro Ala Ala Leu Leu His Ala Asn 210 215 220 agg tgg ata agc gac agt cgt gat gag tac act aag gaa aga ctt gag 720 Arg Trp Ile Ser Asp Ser Arg Asp Glu Tyr Thr Lys Glu Arg Leu Glu 225 230 235 240 gct att gac gat gag ttc aag ctt tac cgt tgt cat acg atc ttg aac 768 Ala Ile Asp Asp Glu Phe Lys Leu Tyr Arg Cys His Thr Ile Leu Asn 245 250 255 tgt gct cgt gct tgt cct aag ggt ttg aac ccg ggc aaa cag atc gcg 816 Cys Ala Arg Ala Cys Pro Lys Gly Leu Asn Pro Gly Lys Gln Ile Ala 260 265 270 cac att aag caa ctt cag cgt tga 840 His Ile Lys Gln Leu Gln Arg 275 <210> 329 <211> 279 <212> PRT <213> Brassica napus <400> 329 Met Ser Ser Gly Leu Ile Gly Arg Leu Val Gly Thr Lys Pro Ser Arg 1 5 10 15 Leu Thr Thr Ala Ala Arg Leu Ile Pro Ser Arg Cys Thr Ala Ser Val 20 25 30 Thr Glu Pro Glu Pro Lys Ala Ser Ser Gly Gly Gly Lys Pro Ser Asn 35 40 45 Phe Lys Thr Phe Gln Ile Tyr Arg Trp Asn Pro Asp Asn Pro Ser Lys 50 55 60 Pro Glu Leu Gln Asp Tyr Lys Ile Asp Leu Lys Asp Cys Gly Pro Met 65 70 75 80 Val Leu Asp Ala Leu Ile Lys Ile Lys Asn Glu Met Asp Pro Ser Leu 85 90 95 Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser Cys Ala Met 100 105 110 Asn Ile Asp Gly Cys Asn Gly Leu Ala Cys Leu Thr Lys Ile Glu Glu 115 120 125 Gly Ala Lys Glu Thr Thr Ile Thr Pro Leu Pro His Met Phe Val Ile 130 135 140 Lys Asp Leu Val Val Asp Met Thr Asn Phe Tyr Asn Gln Tyr Lys Ser 145 150 155 160 Ile Glu Pro Trp Leu Lys Arg Lys Asn Pro Pro Ser Glu Pro Gly Lys 165 170 175 Glu Ile Leu Gln Ser Lys Lys Asp Arg Ala Lys Leu Asp Gly Met Tyr 180 185 190 Page 455 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Tyr Trp 195 200 205 Trp Asn Pro Glu Ser Tyr Leu Gly Pro Ala Ala Leu Leu His Ala Asn 210 215 220 Arg Trp Ile Ser Asp Ser Arg Asp Glu Tyr Thr Lys Glu Arg Leu Glu 225 230 235 240 Ala Ile Asp Asp Glu Phe Lys Leu Tyr Arg Cys His Thr Ile Leu Asn 245 250 255 Cys Ala Arg Ala Cys Pro Lys Gly Leu Asn Pro Gly Lys Gln Ile Ala 260 265 270 His Ile Lys Gln Leu Gln Arg 275 <210> 330 <211> 1074 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1074) <400> 330 atg gga gag gtc ctt aag aag gag gcg tac gga ctg gct gta aaa gac 48 Met Gly Glu Val Leu Lys Lys Glu Ala Tyr Gly Leu Ala Val Lys Asp 1 5 10 15 gaa tct gga gtt atc tcg cct ttc cgt ttc tca aga agg gag aca gga 96 Glu Ser Gly Val Ile Ser Pro Phe Arg Phe Ser Arg Arg Glu Thr Gly 20 25 30 gaa aat gat gtg agg tta aaa gtg ttg ttc tgt gga att tgc cac aca 144 Glu Asn Asp Val Arg Leu Lys Val Leu Phe Cys Gly Ile Cys His Thr 35 40 45 gat tta agc atg gcc ata aac gag tgg ggg ttt act agt tac ccc ctt 192 Asp Leu Ser Met Ala Ile Asn Glu Trp Gly Phe Thr Ser Tyr Pro Leu 50 55 60 gtc ccc ggg cat gaa ata gtg ggc gtg gtg act gaa gtc gga gcc aaa 240 Val Pro Gly His Glu Ile Val Gly Val Val Thr Glu Val Gly Ala Lys 65 70 75 80 gtg act aaa ttc aac gcc gga gac aaa gtg gga gtt ggt tat atg gtc 288 Val Thr Lys Phe Asn Ala Gly Asp Lys Val Gly Val Gly Tyr Met Val 85 90 95 agc tca tgc ggg tca tgt gaa acc tgc att gat gac caa gag aac tac 336 Ser Ser Cys Gly Ser Cys Glu Thr Cys Ile Asp Asp Gln Glu Asn Tyr 100 105 110 tgt cca aaa atg atc cta acg tcc gga ggc aag tat tac gat gac act 384 Cys Pro Lys Met Ile Leu Thr Ser Gly Gly Lys Tyr Tyr Asp Asp Thr 115 120 125 ata aca tat ggt ggt tac tcc gac cat atg gtt tgt gaa gag gac tac 432 Ile Thr Tyr Gly Gly Tyr Ser Asp His Met Val Cys Glu Glu Asp Tyr 130 135 140 atc atc cgt att cca gaa aat ctt ccc tta gac gct acc gcg ccg cta 480 Ile Ile Arg Ile Pro Glu Asn Leu Pro Leu Asp Ala Thr Ala Pro Leu 145 150 155 160 ctc tgc gct ggg acc acc gtc tat tcc ccg atg aag tat cac ggg ctt 528 Leu Cys Ala Gly Thr Thr Val Tyr Ser Pro Met Lys Tyr His Gly Leu 165 170 175 gac aag ccg ggt atg cac att ggt gtg gtg gga cta ggc ggt tta ggt 576 Asp Lys Pro Gly Met His Ile Gly Val Val Gly Leu Gly Gly Leu Gly 180 185 190 cat gta gct gtg aaa ttt gct aag gct atg ggt act aag gtt aca gtt 624 His Val Ala Val Lys Phe Ala Lys Ala Met Gly Thr Lys Val Thr Val 195 200 205 att agt act tcg gat agg aag aga gac gag gcg tta act cgg ctt ggt 672 Ile Ser Thr Ser Asp Arg Lys Arg Asp Glu Ala Leu Thr Arg Leu Gly 210 215 220 gcg gat ctg ttc ttg gtg agc cgt gac ccg gaa cag atg aag gat gca 720 Ala Asp Leu Phe Leu Val Ser Arg Asp Pro Glu Gln Met Lys Asp Ala 225 230 235 240 Page 456 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atg ggt act atg gat ggt att att gat acc gta tct gct tct cat cca 768 Met Gly Thr Met Asp Gly Ile Ile Asp Thr Val Ser Ala Ser His Pro 245 250 255 gtt ctt ccg att ctt gat ttg ctt aaa tat aag ggt aaa ctt att atg 816 Val Leu Pro Ile Leu Asp Leu Leu Lys Tyr Lys Gly Lys Leu Ile Met 260 265 270 gtt ggt gca cct gat aaa ccg ctt gag ctt ccg gtt ctg cct ctc atc 864 Val Gly Ala Pro Asp Lys Pro Leu Glu Leu Pro Val Leu Pro Leu Ile 275 280 285 ttt ggg aaa aag atg gtg gtg gga agt atg gta gga ggg ata aaa gag 912 Phe Gly Lys Lys Met Val Val Gly Ser Met Val Gly Gly Ile Lys Glu 290 295 300 act caa gag atg atg gat ttg gcc gga aaa cac aac atc acg gca gat 960 Thr Gln Glu Met Met Asp Leu Ala Gly Lys His Asn Ile Thr Ala Asp 305 310 315 320 att gag ctt atc tct gcg gat tat gtc aac act gcc atg aaa cgg ctc 1008 Ile Glu Leu Ile Ser Ala Asp Tyr Val Asn Thr Ala Met Lys Arg Leu 325 330 335 gag aag gct gac gtt aga tac cgt ttt gtg att gat gtt gcc aac acc 1056 Glu Lys Ala Asp Val Arg Tyr Arg Phe Val Ile Asp Val Ala Asn Thr 340 345 350 ttg aag cct agt cct taa 1074 Leu Lys Pro Ser Pro 355 <210> 331 <211> 357 <212> PRT <213> Brassica napus <400> 331 Met Gly Glu Val Leu Lys Lys Glu Ala Tyr Gly Leu Ala Val Lys Asp 1 5 10 15 Glu Ser Gly Val Ile Ser Pro Phe Arg Phe Ser Arg Arg Glu Thr Gly 20 25 30 Glu Asn Asp Val Arg Leu Lys Val Leu Phe Cys Gly Ile Cys His Thr 35 40 45 Asp Leu Ser Met Ala Ile Asn Glu Trp Gly Phe Thr Ser Tyr Pro Leu 50 55 60 Val Pro Gly His Glu Ile Val Gly Val Val Thr Glu Val Gly Ala Lys 65 70 75 80 Val Thr Lys Phe Asn Ala Gly Asp Lys Val Gly Val Gly Tyr Met Val 85 90 95 Ser Ser Cys Gly Ser Cys Glu Thr Cys Ile Asp Asp Gln Glu Asn Tyr 100 105 110 Cys Pro Lys Met Ile Leu Thr Ser Gly Gly Lys Tyr Tyr Asp Asp Thr 115 120 125 Ile Thr Tyr Gly Gly Tyr Ser Asp His Met Val Cys Glu Glu Asp Tyr 130 135 140 Ile Ile Arg Ile Pro Glu Asn Leu Pro Leu Asp Ala Thr Ala Pro Leu 145 150 155 160 Leu Cys Ala Gly Thr Thr Val Tyr Ser Pro Met Lys Tyr His Gly Leu 165 170 175 Asp Lys Pro Gly Met His Ile Gly Val Val Gly Leu Gly Gly Leu Gly 180 185 190 His Val Ala Val Lys Phe Ala Lys Ala Met Gly Thr Lys Val Thr Val 195 200 205 Ile Ser Thr Ser Asp Arg Lys Arg Asp Glu Ala Leu Thr Arg Leu Gly 210 215 220 Ala Asp Leu Phe Leu Val Ser Arg Asp Pro Glu Gln Met Lys Asp Ala 225 230 235 240 Met Gly Thr Met Asp Gly Ile Ile Asp Thr Val Ser Ala Ser His Pro 245 250 255 Val Leu Pro Ile Leu Asp Leu Leu Lys Tyr Lys Gly Lys Leu Ile Met 260 265 270 Val Gly Ala Pro Asp Lys Pro Leu Glu Leu Pro Val Leu Pro Leu Ile 275 280 285 Phe Gly Lys Lys Met Val Val Gly Ser Met Val Gly Gly Ile Lys Glu Page 457 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 290 295 300 Thr Gln Glu Met Met Asp Leu Ala Gly Lys His Asn Ile Thr Ala Asp 305 310 315 320 Ile Glu Leu Ile Ser Ala Asp Tyr Val Asn Thr Ala Met Lys Arg Leu 325 330 335 Glu Lys Ala Asp Val Arg Tyr Arg Phe Val Ile Asp Val Ala Asn Thr 340 345 350 Leu Lys Pro Ser Pro 355 <210> 332 <211> 651 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(651) <400> 332 atg gct tca act gct tca aag ttc ata aaa tgt gtg act gtt ggt gat 48 Met Ala Ser Thr Ala Ser Lys Phe Ile Lys Cys Val Thr Val Gly Asp 1 5 10 15 ggc gcc gta ggt aaa acc tgt atg ctc atc tgc tac acc agc aac aaa 96 Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn Lys 20 25 30 ttc cct act gac tac ata cca aca gtt ttt gac aac ttt agt gca aac 144 Phe Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser Ala Asn 35 40 45 gtt gta gtt gaa ggc acc act gtg aac cta ggc cta tgg gac act gct 192 Val Val Val Glu Gly Thr Thr Val Asn Leu Gly Leu Trp Asp Thr Ala 50 55 60 ggg caa gaa gac tac aac aga tta agg cct tta agt tac aga gga gca 240 Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala 65 70 75 80 gat gtt ttc gtc ctg tct ttc tcc ttg gtc agc cga gct agc tac gag 288 Asp Val Phe Val Leu Ser Phe Ser Leu Val Ser Arg Ala Ser Tyr Glu 85 90 95 aat gtt tat aaa aag tgg atc cct gaa ctc caa cac ttt gcc cca gga 336 Asn Val Tyr Lys Lys Trp Ile Pro Glu Leu Gln His Phe Ala Pro Gly 100 105 110 gtt cca tta gtc ctt gtt ggt acc aaa cta gat ctc cgt gaa gat aat 384 Val Pro Leu Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Asn 115 120 125 aag cat tat ttg gct gac cat cct gga cta tcc cct gta act act gca 432 Lys His Tyr Leu Ala Asp His Pro Gly Leu Ser Pro Val Thr Thr Ala 130 135 140 cag gga gag gaa ttg cgt aag cta atc ggt gcg aca tat tac att gaa 480 Gln Gly Glu Glu Leu Arg Lys Leu Ile Gly Ala Thr Tyr Tyr Ile Glu 145 150 155 160 tgt agc tcg aaa act caa cag aat gtg aaa gca gtt ttt gat tca gcg 528 Cys Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ser Ala 165 170 175 atc aag gaa gtg atc aaa ccg gtg gtt aaa caa aag gag aag acg cag 576 Ile Lys Glu Val Ile Lys Pro Val Val Lys Gln Lys Glu Lys Thr Gln 180 185 190 aaa acg aag aag caa aag tct aat cat ggc tgt tta tca aac gtt ctg 624 Lys Thr Lys Lys Gln Lys Ser Asn His Gly Cys Leu Ser Asn Val Leu 195 200 205 tgt ggg agg ata gtg act cgg cat tga 651 Cys Gly Arg Ile Val Thr Arg His 210 215 <210> 333 <211> 216 <212> PRT <213> Brassica napus Page 458 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 333 Met Ala Ser Thr Ala Ser Lys Phe Ile Lys Cys Val Thr Val Gly Asp 1 5 10 15 Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn Lys 20 25 30 Phe Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser Ala Asn 35 40 45 Val Val Val Glu Gly Thr Thr Val Asn Leu Gly Leu Trp Asp Thr Ala 50 55 60 Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala 65 70 75 80 Asp Val Phe Val Leu Ser Phe Ser Leu Val Ser Arg Ala Ser Tyr Glu 85 90 95 Asn Val Tyr Lys Lys Trp Ile Pro Glu Leu Gln His Phe Ala Pro Gly 100 105 110 Val Pro Leu Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Asn 115 120 125 Lys His Tyr Leu Ala Asp His Pro Gly Leu Ser Pro Val Thr Thr Ala 130 135 140 Gln Gly Glu Glu Leu Arg Lys Leu Ile Gly Ala Thr Tyr Tyr Ile Glu 145 150 155 160 Cys Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ser Ala 165 170 175 Ile Lys Glu Val Ile Lys Pro Val Val Lys Gln Lys Glu Lys Thr Gln 180 185 190 Lys Thr Lys Lys Gln Lys Ser Asn His Gly Cys Leu Ser Asn Val Leu 195 200 205 Cys Gly Arg Ile Val Thr Arg His 210 215 <210> 334 <211> 1074 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1074) <400> 334 atg gga aag gtg cct gcg acg gag gcg ttc gga ttg gcc gcg aaa gac 48 Met Gly Lys Val Pro Ala Thr Glu Ala Phe Gly Leu Ala Ala Lys Asp 1 5 10 15 gaa tcc gga gtt ctc tcg cct ttc cgt ttc tca aga agg gag acg gga 96 Glu Ser Gly Val Leu Ser Pro Phe Arg Phe Ser Arg Arg Glu Thr Gly 20 25 30 gag aag gat gtg agg tta aaa gtg ttg ttc tgt gga att tgc cac act 144 Glu Lys Asp Val Arg Leu Lys Val Leu Phe Cys Gly Ile Cys His Thr 35 40 45 gat gta tgt atg gcc aga aac gag tgg gga ttt act act tac cct ctc 192 Asp Val Cys Met Ala Arg Asn Glu Trp Gly Phe Thr Thr Tyr Pro Leu 50 55 60 gtc ccc ggg cat gag att gtt ggc gtg gtg act gaa gtc gga gct aaa 240 Val Pro Gly His Glu Ile Val Gly Val Val Thr Glu Val Gly Ala Lys 65 70 75 80 gtg att aaa ttc aaa gcc gga gac aaa gtc gga gtt ggt tat atg ctc 288 Val Ile Lys Phe Lys Ala Gly Asp Lys Val Gly Val Gly Tyr Met Leu 85 90 95 agc tcg tgc cgg tca tgt gac atc tgc acc gat gac caa gag aac cac 336 Ser Ser Cys Arg Ser Cys Asp Ile Cys Thr Asp Asp Gln Glu Asn His 100 105 110 tgt cca aaa atg att atg acg tcc gga gga aag tac tac gat gac acc 384 Cys Pro Lys Met Ile Met Thr Ser Gly Gly Lys Tyr Tyr Asp Asp Thr 115 120 125 atg act tat ggt ggt tac tct gac cac ctg gtt tgt gaa gag gat tac 432 Met Thr Tyr Gly Gly Tyr Ser Asp His Leu Val Cys Glu Glu Asp Tyr 130 135 140 atc atc cgt att cct gaa aat ctc ccg tta gac gct gcc gcg ccg cta 480 Page 459 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Ile Arg Ile Pro Glu Asn Leu Pro Leu Asp Ala Ala Ala Pro Leu 145 150 155 160 ctc tgc gct ggg gtc acg gtt tat tca ccg ttg aag tct cac gga ctc 528 Leu Cys Ala Gly Val Thr Val Tyr Ser Pro Leu Lys Ser His Gly Leu 165 170 175 gac aag ccc gga atc cac att ggt gtg gtg gga cta ggc ggt tta ggt 576 Asp Lys Pro Gly Ile His Ile Gly Val Val Gly Leu Gly Gly Leu Gly 180 185 190 cac gta gca gtg aaa ttt gcc aag gct atg ggt act aag gtt acg gtt 624 His Val Ala Val Lys Phe Ala Lys Ala Met Gly Thr Lys Val Thr Val 195 200 205 att agt tcg tca gat ggt aag aga gac gag gcg att aat cgg ctt ggt 672 Ile Ser Ser Ser Asp Gly Lys Arg Asp Glu Ala Ile Asn Arg Leu Gly 210 215 220 gcg gat ctg ttc ttg gtg agc cgt gac ccg gaa gag atg aag gat gca 720 Ala Asp Leu Phe Leu Val Ser Arg Asp Pro Glu Glu Met Lys Asp Ala 225 230 235 240 atg ggg act atg gat ggt att att gat aca gta tct gcc act cat ccg 768 Met Gly Thr Met Asp Gly Ile Ile Asp Thr Val Ser Ala Thr His Pro 245 250 255 ctt ctt ccg ctt ctt ggt ttg cta aaa tat aag gga aaa ttt att atg 816 Leu Leu Pro Leu Leu Gly Leu Leu Lys Tyr Lys Gly Lys Phe Ile Met 260 265 270 gtt ggt gca ccc gat aaa cca ctt gac ctt cca gct tta ccg ctc atc 864 Val Gly Ala Pro Asp Lys Pro Leu Asp Leu Pro Ala Leu Pro Leu Ile 275 280 285 tta ggg aag aag atg gtg gtg gga agt atg aca gga ggg ata aaa gag 912 Leu Gly Lys Lys Met Val Val Gly Ser Met Thr Gly Gly Ile Lys Glu 290 295 300 tct caa gag atg gtt gat ttt gcc ggt aaa cac aac ata acg gca gat 960 Ser Gln Glu Met Val Asp Phe Ala Gly Lys His Asn Ile Thr Ala Asp 305 310 315 320 att gag ctt atc tct gcg gat tat gtc aac atg gct atg gaa cgg cta 1008 Ile Glu Leu Ile Ser Ala Asp Tyr Val Asn Met Ala Met Glu Arg Leu 325 330 335 gaa aag ggg gat gtt aga tac cgt ttt gtg att gat gtt gcc aac aca 1056 Glu Lys Gly Asp Val Arg Tyr Arg Phe Val Ile Asp Val Ala Asn Thr 340 345 350 atg aag cct act cct tag 1074 Met Lys Pro Thr Pro 355 <210> 335 <211> 357 <212> PRT <213> Brassica napus <400> 335 Met Gly Lys Val Pro Ala Thr Glu Ala Phe Gly Leu Ala Ala Lys Asp 1 5 10 15 Glu Ser Gly Val Leu Ser Pro Phe Arg Phe Ser Arg Arg Glu Thr Gly 20 25 30 Glu Lys Asp Val Arg Leu Lys Val Leu Phe Cys Gly Ile Cys His Thr 35 40 45 Asp Val Cys Met Ala Arg Asn Glu Trp Gly Phe Thr Thr Tyr Pro Leu 50 55 60 Val Pro Gly His Glu Ile Val Gly Val Val Thr Glu Val Gly Ala Lys 65 70 75 80 Val Ile Lys Phe Lys Ala Gly Asp Lys Val Gly Val Gly Tyr Met Leu 85 90 95 Ser Ser Cys Arg Ser Cys Asp Ile Cys Thr Asp Asp Gln Glu Asn His 100 105 110 Cys Pro Lys Met Ile Met Thr Ser Gly Gly Lys Tyr Tyr Asp Asp Thr 115 120 125 Met Thr Tyr Gly Gly Tyr Ser Asp His Leu Val Cys Glu Glu Asp Tyr 130 135 140 Ile Ile Arg Ile Pro Glu Asn Leu Pro Leu Asp Ala Ala Ala Pro Leu 145 150 155 160 Page 460 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Cys Ala Gly Val Thr Val Tyr Ser Pro Leu Lys Ser His Gly Leu 165 170 175 Asp Lys Pro Gly Ile His Ile Gly Val Val Gly Leu Gly Gly Leu Gly 180 185 190 His Val Ala Val Lys Phe Ala Lys Ala Met Gly Thr Lys Val Thr Val 195 200 205 Ile Ser Ser Ser Asp Gly Lys Arg Asp Glu Ala Ile Asn Arg Leu Gly 210 215 220 Ala Asp Leu Phe Leu Val Ser Arg Asp Pro Glu Glu Met Lys Asp Ala 225 230 235 240 Met Gly Thr Met Asp Gly Ile Ile Asp Thr Val Ser Ala Thr His Pro 245 250 255 Leu Leu Pro Leu Leu Gly Leu Leu Lys Tyr Lys Gly Lys Phe Ile Met 260 265 270 Val Gly Ala Pro Asp Lys Pro Leu Asp Leu Pro Ala Leu Pro Leu Ile 275 280 285 Leu Gly Lys Lys Met Val Val Gly Ser Met Thr Gly Gly Ile Lys Glu 290 295 300 Ser Gln Glu Met Val Asp Phe Ala Gly Lys His Asn Ile Thr Ala Asp 305 310 315 320 Ile Glu Leu Ile Ser Ala Asp Tyr Val Asn Met Ala Met Glu Arg Leu 325 330 335 Glu Lys Gly Asp Val Arg Tyr Arg Phe Val Ile Asp Val Ala Asn Thr 340 345 350 Met Lys Pro Thr Pro 355 <210> 336 <211> 1074 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1074) <400> 336 atg ggg aaa atg gag gta gag agg aaa aca aca ggc tgg gct gcg aga 48 Met Gly Lys Met Glu Val Glu Arg Lys Thr Thr Gly Trp Ala Ala Arg 1 5 10 15 gac cct tct ggg tta ctc tct cct tac act tac act ctc aga gag aca 96 Asp Pro Ser Gly Leu Leu Ser Pro Tyr Thr Tyr Thr Leu Arg Glu Thr 20 25 30 gga cca gag gat gtt cac ata aga atc ata tgc tgt gga atc tgc cac 144 Gly Pro Glu Asp Val His Ile Arg Ile Ile Cys Cys Gly Ile Cys His 35 40 45 aca gat ctc cat caa acc aaa aac gat ctt ggc atg tca aac tac ccc 192 Thr Asp Leu His Gln Thr Lys Asn Asp Leu Gly Met Ser Asn Tyr Pro 50 55 60 atg gtt cct ggg cac gag gtt gtt ggg gaa gtg gtg gag gtg gga tca 240 Met Val Pro Gly His Glu Val Val Gly Glu Val Val Glu Val Gly Ser 65 70 75 80 gat gtg agc aag ttc acc gca ggg gat ata gtt gga gtt ggt tgt ctc 288 Asp Val Ser Lys Phe Thr Ala Gly Asp Ile Val Gly Val Gly Cys Leu 85 90 95 gtt gga tgc tgc gga ggt tgt agc ccc tgc gag aga gat ctg gaa cag 336 Val Gly Cys Cys Gly Gly Cys Ser Pro Cys Glu Arg Asp Leu Glu Gln 100 105 110 tat tgt ccc aag aag atc tgg agc tac aac gat gtt tac atc gat ggt 384 Tyr Cys Pro Lys Lys Ile Trp Ser Tyr Asn Asp Val Tyr Ile Asp Gly 115 120 125 caa cca aca caa ggc ggt ttc gct aga gcc acc gtc gtt cac caa aag 432 Gln Pro Thr Gln Gly Gly Phe Ala Arg Ala Thr Val Val His Gln Lys 130 135 140 ttt gtg gtg aag att cca gaa gga atg gct gtt gag cag gcg gca cca 480 Phe Val Val Lys Ile Pro Glu Gly Met Ala Val Glu Gln Ala Ala Pro 145 150 155 160 cta ctg tgt gcc ggt gtg aca gtg tac agt cca ctg gct cac ttc ggt 528 Page 461 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Leu Cys Ala Gly Val Thr Val Tyr Ser Pro Leu Ala His Phe Gly 165 170 175 ctg aag cga cca ggc cta aga gga ggt ata cta ggg cta ggt gga gtt 576 Leu Lys Arg Pro Gly Leu Arg Gly Gly Ile Leu Gly Leu Gly Gly Val 180 185 190 ggt cac atg ggt gtg aaa ata gcc aaa gca atg ggt cac cat gtg act 624 Gly His Met Gly Val Lys Ile Ala Lys Ala Met Gly His His Val Thr 195 200 205 gtc ata agc tca tca aac aag aag aaa gaa gag gct ttg aaa gat ctt 672 Val Ile Ser Ser Ser Asn Lys Lys Lys Glu Glu Ala Leu Lys Asp Leu 210 215 220 gga gca gat gat tac gtg atc gga tcc gac caa tcg aag atg aac gaa 720 Gly Ala Asp Asp Tyr Val Ile Gly Ser Asp Gln Ser Lys Met Asn Glu 225 230 235 240 ttg gcg gat tca atg gat tac ata atc gac acg gtc cct gtt cat cat 768 Leu Ala Asp Ser Met Asp Tyr Ile Ile Asp Thr Val Pro Val His His 245 250 255 gca ctt gag cct tac ttg tct ctg ctt agg ctt gat ggg aaa ctc ata 816 Ala Leu Glu Pro Tyr Leu Ser Leu Leu Arg Leu Asp Gly Lys Leu Ile 260 265 270 ctc atg gga gtc ata agc aat cca tta caa ttt ctc act cct atg gtt 864 Leu Met Gly Val Ile Ser Asn Pro Leu Gln Phe Leu Thr Pro Met Val 275 280 285 atg ctt ggg agg aaa gtg ata acg ggg agc ttc att ggg agc atg aag 912 Met Leu Gly Arg Lys Val Ile Thr Gly Ser Phe Ile Gly Ser Met Lys 290 295 300 gaa aca gag gag atg ctt gag ttc tgt aaa gaa aag ggt ttg agt tcg 960 Glu Thr Glu Glu Met Leu Glu Phe Cys Lys Glu Lys Gly Leu Ser Ser 305 310 315 320 atc atc gaa gta gtg aag atg gat tat gtg aac act gcg ttt gag aga 1008 Ile Ile Glu Val Val Lys Met Asp Tyr Val Asn Thr Ala Phe Glu Arg 325 330 335 ctc gag aag aac gat gtg cgt tat agg ttc gtg gtt gat gtc gaa gga 1056 Leu Glu Lys Asn Asp Val Arg Tyr Arg Phe Val Val Asp Val Glu Gly 340 345 350 agc aaa ctt gag gct tga 1074 Ser Lys Leu Glu Ala 355 <210> 337 <211> 357 <212> PRT <213> Brassica napus <400> 337 Met Gly Lys Met Glu Val Glu Arg Lys Thr Thr Gly Trp Ala Ala Arg 1 5 10 15 Asp Pro Ser Gly Leu Leu Ser Pro Tyr Thr Tyr Thr Leu Arg Glu Thr 20 25 30 Gly Pro Glu Asp Val His Ile Arg Ile Ile Cys Cys Gly Ile Cys His 35 40 45 Thr Asp Leu His Gln Thr Lys Asn Asp Leu Gly Met Ser Asn Tyr Pro 50 55 60 Met Val Pro Gly His Glu Val Val Gly Glu Val Val Glu Val Gly Ser 65 70 75 80 Asp Val Ser Lys Phe Thr Ala Gly Asp Ile Val Gly Val Gly Cys Leu 85 90 95 Val Gly Cys Cys Gly Gly Cys Ser Pro Cys Glu Arg Asp Leu Glu Gln 100 105 110 Tyr Cys Pro Lys Lys Ile Trp Ser Tyr Asn Asp Val Tyr Ile Asp Gly 115 120 125 Gln Pro Thr Gln Gly Gly Phe Ala Arg Ala Thr Val Val His Gln Lys 130 135 140 Phe Val Val Lys Ile Pro Glu Gly Met Ala Val Glu Gln Ala Ala Pro 145 150 155 160 Leu Leu Cys Ala Gly Val Thr Val Tyr Ser Pro Leu Ala His Phe Gly 165 170 175 Leu Lys Arg Pro Gly Leu Arg Gly Gly Ile Leu Gly Leu Gly Gly Val Page 462 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 180 185 190 Gly His Met Gly Val Lys Ile Ala Lys Ala Met Gly His His Val Thr 195 200 205 Val Ile Ser Ser Ser Asn Lys Lys Lys Glu Glu Ala Leu Lys Asp Leu 210 215 220 Gly Ala Asp Asp Tyr Val Ile Gly Ser Asp Gln Ser Lys Met Asn Glu 225 230 235 240 Leu Ala Asp Ser Met Asp Tyr Ile Ile Asp Thr Val Pro Val His His 245 250 255 Ala Leu Glu Pro Tyr Leu Ser Leu Leu Arg Leu Asp Gly Lys Leu Ile 260 265 270 Leu Met Gly Val Ile Ser Asn Pro Leu Gln Phe Leu Thr Pro Met Val 275 280 285 Met Leu Gly Arg Lys Val Ile Thr Gly Ser Phe Ile Gly Ser Met Lys 290 295 300 Glu Thr Glu Glu Met Leu Glu Phe Cys Lys Glu Lys Gly Leu Ser Ser 305 310 315 320 Ile Ile Glu Val Val Lys Met Asp Tyr Val Asn Thr Ala Phe Glu Arg 325 330 335 Leu Glu Lys Asn Asp Val Arg Tyr Arg Phe Val Val Asp Val Glu Gly 340 345 350 Ser Lys Leu Glu Ala 355 <210> 338 <211> 651 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(651) <400> 338 atg gct tca agt gct tca aag ttc atc aaa tgt gta act gtt ggt gat 48 Met Ala Ser Ser Ala Ser Lys Phe Ile Lys Cys Val Thr Val Gly Asp 1 5 10 15 ggt gcc gtt ggt aaa acc tgt atg ctc atc tgc tat acc agc aac aag 96 Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn Lys 20 25 30 ttc cct act gac tat gta cca acg gtt ttt gac aac ttt agt gca aac 144 Phe Pro Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn 35 40 45 gtt gta gtt gaa gga act act gtg aac tta ggg cta tgg gat act gct 192 Val Val Val Glu Gly Thr Thr Val Asn Leu Gly Leu Trp Asp Thr Ala 50 55 60 gga caa gaa gac tat aac aga tta agg cct tta agc tac aga gga gca 240 Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala 65 70 75 80 gat gtc ttc gtc ttg tct ttc tca ttg gtt agc cga gct agc tac gag 288 Asp Val Phe Val Leu Ser Phe Ser Leu Val Ser Arg Ala Ser Tyr Glu 85 90 95 aat gtt ttt aaa aag tgg atc cct gaa ctc caa cac ttt gct cca gga 336 Asn Val Phe Lys Lys Trp Ile Pro Glu Leu Gln His Phe Ala Pro Gly 100 105 110 gtt cca tta gtt ctt gtc ggt acc aaa tta gat ctc cgt gag gat aag 384 Val Pro Leu Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Lys 115 120 125 cat tat ctg gct gac cat cct gga cta tcc cct gta act act gca cag 432 His Tyr Leu Ala Asp His Pro Gly Leu Ser Pro Val Thr Thr Ala Gln 130 135 140 gga gag gag ttg cgt aag ctc att ggt gca aca tat tac att gaa tgt 480 Gly Glu Glu Leu Arg Lys Leu Ile Gly Ala Thr Tyr Tyr Ile Glu Cys 145 150 155 160 agc tca aaa act caa cag aat gtc aaa gca gtt ttt gat tcg gca atc 528 Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ser Ala Ile 165 170 175 aag gaa gtg atc aaa ccg gtg ctt aaa cag aag ggc aag acc aag aaa 576 Page 463 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Glu Val Ile Lys Pro Val Leu Lys Gln Lys Gly Lys Thr Lys Lys 180 185 190 aag aag aag caa cag tcg aat cac cac ggg tgt tta tca aac gtt ttg 624 Lys Lys Lys Gln Gln Ser Asn His His Gly Cys Leu Ser Asn Val Leu 195 200 205 tgt ggg agg ata gtg acc cgg cat tga 651 Cys Gly Arg Ile Val Thr Arg His 210 215 <210> 339 <211> 216 <212> PRT <213> Brassica napus <400> 339 Met Ala Ser Ser Ala Ser Lys Phe Ile Lys Cys Val Thr Val Gly Asp 1 5 10 15 Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn Lys 20 25 30 Phe Pro Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn 35 40 45 Val Val Val Glu Gly Thr Thr Val Asn Leu Gly Leu Trp Asp Thr Ala 50 55 60 Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala 65 70 75 80 Asp Val Phe Val Leu Ser Phe Ser Leu Val Ser Arg Ala Ser Tyr Glu 85 90 95 Asn Val Phe Lys Lys Trp Ile Pro Glu Leu Gln His Phe Ala Pro Gly 100 105 110 Val Pro Leu Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Lys 115 120 125 His Tyr Leu Ala Asp His Pro Gly Leu Ser Pro Val Thr Thr Ala Gln 130 135 140 Gly Glu Glu Leu Arg Lys Leu Ile Gly Ala Thr Tyr Tyr Ile Glu Cys 145 150 155 160 Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ser Ala Ile 165 170 175 Lys Glu Val Ile Lys Pro Val Leu Lys Gln Lys Gly Lys Thr Lys Lys 180 185 190 Lys Lys Lys Gln Gln Ser Asn His His Gly Cys Leu Ser Asn Val Leu 195 200 205 Cys Gly Arg Ile Val Thr Arg His 210 215 <210> 340 <211> 348 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(348) <400> 340 atg tca gat ctt gaa gtt caa gtc ccc act gcc ttt gat ccg ttt gct 48 Met Ser Asp Leu Glu Val Gln Val Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 gat gca aat gct gag gac gct gga gct gga gct gga aca aag gaa tac 96 Asp Ala Asn Ala Glu Asp Ala Gly Ala Gly Ala Gly Thr Lys Glu Tyr 20 25 30 gtg cac ata cgt gtt cag cag cgt aat ggt aga aaa agc ctg acc act 144 Val His Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 gtc cag ggc ctt aag aaa gag tat agc tat acc aag atc ctc aaa gac 192 Val Gln Gly Leu Lys Lys Glu Tyr Ser Tyr Thr Lys Ile Leu Lys Asp 50 55 60 ctc aag aaa gag ttt tgc tgc aat ggc acc gtc gtc caa gac tct gag 240 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Ser Glu Page 464 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 65 70 75 80 cta gga cag gtt att cag ctt caa ggt gat cag agg aag aac gtg tcc 288 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser 85 90 95 acc ttc ctt gtt cag gct ggt ctt gtg aag aag gat aac atc aag atc 336 Thr Phe Leu Val Gln Ala Gly Leu Val Lys Lys Asp Asn Ile Lys Ile 100 105 110 cat ggt ttt tga 348 His Gly Phe 115 <210> 341 <211> 115 <212> PRT <213> Brassica napus <400> 341 Met Ser Asp Leu Glu Val Gln Val Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 Asp Ala Asn Ala Glu Asp Ala Gly Ala Gly Ala Gly Thr Lys Glu Tyr 20 25 30 Val His Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 Val Gln Gly Leu Lys Lys Glu Tyr Ser Tyr Thr Lys Ile Leu Lys Asp 50 55 60 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Ser Glu 65 70 75 80 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser 85 90 95 Thr Phe Leu Val Gln Ala Gly Leu Val Lys Lys Asp Asn Ile Lys Ile 100 105 110 His Gly Phe 115 <210> 342 <211> 1113 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1113) <400> 342 atg agc ctc aaa gcc gga atc gtt ggt ctt cca aat gtc ggg aag tcc 48 Met Ser Leu Lys Ala Gly Ile Val Gly Leu Pro Asn Val Gly Lys Ser 1 5 10 15 act ctc ttt aac gcc gtc gtt gag aat gga aag gcg caa gca gct aat 96 Thr Leu Phe Asn Ala Val Val Glu Asn Gly Lys Ala Gln Ala Ala Asn 20 25 30 ttc ccc ttc tgc aca att gag ccg aat gtt gga att gtg gca gtt cct 144 Phe Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val Ala Val Pro 35 40 45 gat tct cgt ctt caa gtg ctc tct aag ctc acc aac tct cag aaa gtg 192 Asp Ser Arg Leu Gln Val Leu Ser Lys Leu Thr Asn Ser Gln Lys Val 50 55 60 gtc cct gct tcc att gag ttc gtg gac att gct ggt ctt gtc aag ggt 240 Val Pro Ala Ser Ile Glu Phe Val Asp Ile Ala Gly Leu Val Lys Gly 65 70 75 80 gcc agt caa ggc gag gga tta ggg aac aag ttc tta tct cac atc cgt 288 Ala Ser Gln Gly Glu Gly Leu Gly Asn Lys Phe Leu Ser His Ile Arg 85 90 95 gaa gtg gat tcg atc ctc cag gtg gtc cgc tgt ttt gag gac aac gac 336 Glu Val Asp Ser Ile Leu Gln Val Val Arg Cys Phe Glu Asp Asn Asp 100 105 110 att gtt cat gtc aat ggc aaa gtt gat ccc acc tct gac att gat gtc 384 Ile Val His Val Asn Gly Lys Val Asp Pro Thr Ser Asp Ile Asp Val 115 120 125 Page 465 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atc aat ctc gag ctt atc ttc tgc gac ttg gat cag att ggc aaa agg 432 Ile Asn Leu Glu Leu Ile Phe Cys Asp Leu Asp Gln Ile Gly Lys Arg 130 135 140 ctc gac aga ctt aac aaa ggc aag cct aag gat tcc cag tcc aaa gtc 480 Leu Asp Arg Leu Asn Lys Gly Lys Pro Lys Asp Ser Gln Ser Lys Val 145 150 155 160 aag gag gaa gct gaa aaa tct gct ctg caa aga att cag gag gcc ctt 528 Lys Glu Glu Ala Glu Lys Ser Ala Leu Gln Arg Ile Gln Glu Ala Leu 165 170 175 ctg gac ggg aaa cct gca cgc tct gtt gca ttg aat gac ctc gag aag 576 Leu Asp Gly Lys Pro Ala Arg Ser Val Ala Leu Asn Asp Leu Glu Lys 180 185 190 gac gcc gtc aag cat ctc tgc ttg ctt acc atg aag cct atg atc tac 624 Asp Ala Val Lys His Leu Cys Leu Leu Thr Met Lys Pro Met Ile Tyr 195 200 205 gtc gct aat gtt gct gaa acc gat ctt gcc gac cct gac aag aat tct 672 Val Ala Asn Val Ala Glu Thr Asp Leu Ala Asp Pro Asp Lys Asn Ser 210 215 220 ttt gtt caa caa gtt aag gct ctt tct tcg gat ttg cag tct ggt cat 720 Phe Val Gln Gln Val Lys Ala Leu Ser Ser Asp Leu Gln Ser Gly His 225 230 235 240 gtc gtt gtt tct gct cag gtt gag tct gag tta acc gag ctt cct ctt 768 Val Val Val Ser Ala Gln Val Glu Ser Glu Leu Thr Glu Leu Pro Leu 245 250 255 gac gag cgg act gaa tat ttg aac tcg cta ggt gtc agc gag agt ggc 816 Asp Glu Arg Thr Glu Tyr Leu Asn Ser Leu Gly Val Ser Glu Ser Gly 260 265 270 ctt ggg aac ctt atc agg gcc aca tac agt ctg cta ggt ttg cag acc 864 Leu Gly Asn Leu Ile Arg Ala Thr Tyr Ser Leu Leu Gly Leu Gln Thr 275 280 285 tac ttc act tct ggt gaa aag gaa aca aga gcc tgg acg ata cac gca 912 Tyr Phe Thr Ser Gly Glu Lys Glu Thr Arg Ala Trp Thr Ile His Ala 290 295 300 ggc atg act gca cca caa gcc gct agt gtc att cac tct gac ttt gag 960 Gly Met Thr Ala Pro Gln Ala Ala Ser Val Ile His Ser Asp Phe Glu 305 310 315 320 aag ggt ttt att aga gct gag act gtt gca tat gaa gat ttt gtc tct 1008 Lys Gly Phe Ile Arg Ala Glu Thr Val Ala Tyr Glu Asp Phe Val Ser 325 330 335 gct ggc tct ctt gcc gca gca agg gat aaa gga ctt ttg aga tca gag 1056 Ala Gly Ser Leu Ala Ala Ala Arg Asp Lys Gly Leu Leu Arg Ser Glu 340 345 350 ggt aaa gag tac att gtt aaa gaa gga gat gtg atg ctt ttc cgc ttc 1104 Gly Lys Glu Tyr Ile Val Lys Glu Gly Asp Val Met Leu Phe Arg Phe 355 360 365 aac gta taa 1113 Asn Val 370 <210> 343 <211> 370 <212> PRT <213> Brassica napus <400> 343 Met Ser Leu Lys Ala Gly Ile Val Gly Leu Pro Asn Val Gly Lys Ser 1 5 10 15 Thr Leu Phe Asn Ala Val Val Glu Asn Gly Lys Ala Gln Ala Ala Asn 20 25 30 Phe Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val Ala Val Pro 35 40 45 Asp Ser Arg Leu Gln Val Leu Ser Lys Leu Thr Asn Ser Gln Lys Val 50 55 60 Val Pro Ala Ser Ile Glu Phe Val Asp Ile Ala Gly Leu Val Lys Gly 65 70 75 80 Ala Ser Gln Gly Glu Gly Leu Gly Asn Lys Phe Leu Ser His Ile Arg 85 90 95 Glu Val Asp Ser Ile Leu Gln Val Val Arg Cys Phe Glu Asp Asn Asp Page 466 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 100 105 110 Ile Val His Val Asn Gly Lys Val Asp Pro Thr Ser Asp Ile Asp Val 115 120 125 Ile Asn Leu Glu Leu Ile Phe Cys Asp Leu Asp Gln Ile Gly Lys Arg 130 135 140 Leu Asp Arg Leu Asn Lys Gly Lys Pro Lys Asp Ser Gln Ser Lys Val 145 150 155 160 Lys Glu Glu Ala Glu Lys Ser Ala Leu Gln Arg Ile Gln Glu Ala Leu 165 170 175 Leu Asp Gly Lys Pro Ala Arg Ser Val Ala Leu Asn Asp Leu Glu Lys 180 185 190 Asp Ala Val Lys His Leu Cys Leu Leu Thr Met Lys Pro Met Ile Tyr 195 200 205 Val Ala Asn Val Ala Glu Thr Asp Leu Ala Asp Pro Asp Lys Asn Ser 210 215 220 Phe Val Gln Gln Val Lys Ala Leu Ser Ser Asp Leu Gln Ser Gly His 225 230 235 240 Val Val Val Ser Ala Gln Val Glu Ser Glu Leu Thr Glu Leu Pro Leu 245 250 255 Asp Glu Arg Thr Glu Tyr Leu Asn Ser Leu Gly Val Ser Glu Ser Gly 260 265 270 Leu Gly Asn Leu Ile Arg Ala Thr Tyr Ser Leu Leu Gly Leu Gln Thr 275 280 285 Tyr Phe Thr Ser Gly Glu Lys Glu Thr Arg Ala Trp Thr Ile His Ala 290 295 300 Gly Met Thr Ala Pro Gln Ala Ala Ser Val Ile His Ser Asp Phe Glu 305 310 315 320 Lys Gly Phe Ile Arg Ala Glu Thr Val Ala Tyr Glu Asp Phe Val Ser 325 330 335 Ala Gly Ser Leu Ala Ala Ala Arg Asp Lys Gly Leu Leu Arg Ser Glu 340 345 350 Gly Lys Glu Tyr Ile Val Lys Glu Gly Asp Val Met Leu Phe Arg Phe 355 360 365 Asn Val 370 <210> 344 <211> 588 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(588) <400> 344 atg agc gct tcg agg ttc ata aag tgt gtc acc gtc ggc gat ggt gcc 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtc gga aaa acc tgt atg ctg atc tct tac acg agc aac acc ttc cct 96 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gac tat gta cca act gtt ttc gat aac ttc agt gct aat gtg gtt 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtt gat ggg aac act gtg aat ctt ggc ttg tgg gat aca gct ggt caa 192 Val Asp Gly Asn Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gaa gac tat aac agg tta aga cca ttg agt tac cgt ggt gcg gat gtc 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc att ctt gct ttc tct ctt atc agc aaa gct agc tac gag aat ata 288 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 gct aag aag tgg att cct gag ctc agg cac tat gcc cct ggt gtt cct 336 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 att atc ctc gtt gga aca aaa ctc gat ctt cga gat gac aag cag ttc 384 Page 467 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttc ata gac cac cct ggt gca gtg ccg att agt act aac cag gga gag 432 Phe Ile Asp His Pro Gly Ala Val Pro Ile Ser Thr Asn Gln Gly Glu 130 135 140 gaa cta aag aaa ctg ata ggg tct ccg gct tac att gaa tgc agt tca 480 Glu Leu Lys Lys Leu Ile Gly Ser Pro Ala Tyr Ile Glu Cys Ser Ser 145 150 155 160 aag acg cag cag aac gtg aag gca gtc ttt gac gca gcc ata aaa gta 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gtg ctt cag cca cca aag caa aag aag aag aaa aag aag aat ggt tgt 576 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Lys Lys Asn Gly Cys 180 185 190 gtt ttc ttg tga 588 Val Phe Leu 195 <210> 345 <211> 195 <212> PRT <213> Brassica napus <400> 345 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asp Gly Asn Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Ile Asp His Pro Gly Ala Val Pro Ile Ser Thr Asn Gln Gly Glu 130 135 140 Glu Leu Lys Lys Leu Ile Gly Ser Pro Ala Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Lys Lys Asn Gly Cys 180 185 190 Val Phe Leu 195 <210> 346 <211> 495 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(495) <400> 346 atg ccg gcg ggt cac gga gtg agg gcg aga acc agg gat ctg ttc gct 48 Met Pro Ala Gly His Gly Val Arg Ala Arg Thr Arg Asp Leu Phe Ala 1 5 10 15 aga ggg ttc agg aag aag ggt gtt atc cca ctt tcc acc tac ctt agg 96 Arg Gly Phe Arg Lys Lys Gly Val Ile Pro Leu Ser Thr Tyr Leu Arg 20 25 30 acc ttc aaa gtc ggt gat tac gtg gat gtg aag gta aat gga gcc atc 144 Page 468 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Phe Lys Val Gly Asp Tyr Val Asp Val Lys Val Asn Gly Ala Ile 35 40 45 cac aag ggt atg cct cac aag ttc tac cat ggt cgt act ggt cgt gtc 192 His Lys Gly Met Pro His Lys Phe Tyr His Gly Arg Thr Gly Arg Val 50 55 60 tgg aac gtt act aag cga gct gtt ggt gtc gaa gtc aac aag cag att 240 Trp Asn Val Thr Lys Arg Ala Val Gly Val Glu Val Asn Lys Gln Ile 65 70 75 80 ggt aac aga atc att agg aag agg ttg cat gtt cgt gtg gag cac gtg 288 Gly Asn Arg Ile Ile Arg Lys Arg Leu His Val Arg Val Glu His Val 85 90 95 cag cag tca agg tgt gct gag gag ttt aaa cta agg aag aag aat aac 336 Gln Gln Ser Arg Cys Ala Glu Glu Phe Lys Leu Arg Lys Lys Asn Asn 100 105 110 gat gtg ctc aag gct gca gcc aaa gcc aga ggg gag aca atc agc acc 384 Asp Val Leu Lys Ala Ala Ala Lys Ala Arg Gly Glu Thr Ile Ser Thr 115 120 125 aag aga cag cct aaa ggt ccc aag cct ggt ttc atg gtc gag ggt atg 432 Lys Arg Gln Pro Lys Gly Pro Lys Pro Gly Phe Met Val Glu Gly Met 130 135 140 aca ttg gag act gtc act ccc atc cct tac gat gtt gtc aac gat ctc 480 Thr Leu Glu Thr Val Thr Pro Ile Pro Tyr Asp Val Val Asn Asp Leu 145 150 155 160 aag ggt ggc tac taa 495 Lys Gly Gly Tyr <210> 347 <211> 164 <212> PRT <213> Brassica napus <400> 347 Met Pro Ala Gly His Gly Val Arg Ala Arg Thr Arg Asp Leu Phe Ala 1 5 10 15 Arg Gly Phe Arg Lys Lys Gly Val Ile Pro Leu Ser Thr Tyr Leu Arg 20 25 30 Thr Phe Lys Val Gly Asp Tyr Val Asp Val Lys Val Asn Gly Ala Ile 35 40 45 His Lys Gly Met Pro His Lys Phe Tyr His Gly Arg Thr Gly Arg Val 50 55 60 Trp Asn Val Thr Lys Arg Ala Val Gly Val Glu Val Asn Lys Gln Ile 65 70 75 80 Gly Asn Arg Ile Ile Arg Lys Arg Leu His Val Arg Val Glu His Val 85 90 95 Gln Gln Ser Arg Cys Ala Glu Glu Phe Lys Leu Arg Lys Lys Asn Asn 100 105 110 Asp Val Leu Lys Ala Ala Ala Lys Ala Arg Gly Glu Thr Ile Ser Thr 115 120 125 Lys Arg Gln Pro Lys Gly Pro Lys Pro Gly Phe Met Val Glu Gly Met 130 135 140 Thr Leu Glu Thr Val Thr Pro Ile Pro Tyr Asp Val Val Asn Asp Leu 145 150 155 160 Lys Gly Gly Tyr <210> 348 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 348 atg gct cgt acc aag caa acc gca agg aaa tcc acc gga ggc aaa gcc 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala Page 469 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 cca aga aag cag ctc gca acg aaa gca gcc aga aaa tcc gct ccg gcc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acc ggc ggc gtg aag aag cca cac aga ttc cgt cca gga acg gtg gcc 144 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 ttg aga gag atc agg aag tac cag aag agc act gag ctt ctg atc cgt 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctt cct ttc cag cgt ctg gtt cgt gag atc gct cag gat ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acg gat ctg agg ttc cag agc agc gcc gtc gcg gct cta cag gaa gca 288 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gcc gag gct tac ctt gtt ggg tta ttt gag gac acc aat ctc tgt gcg 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cat gcg aag aga gtc act atc atg cct aag gat atc cag ctc gct 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 agg aga atc cgt ggt gaa aga gct tga 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 349 <211> 136 <212> PRT <213> Brassica napus <400> 349 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 350 <211> 492 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(492) <400> 350 atg gcg gat cag ctc acc gac gat cag att ttt ggg ttc aag gaa gca 48 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Phe Gly Phe Lys Glu Ala 1 5 10 15 ttc agt ttt ttc gac aag gat ggt gac ggt tgc att ccc acg agg gag 96 Phe Ser Phe Phe Asp Lys Asp Gly Asp Gly Cys Ile Pro Thr Arg Glu 20 25 30 ttt ggc ccc gtg atg cgt tcc ctg ggt caa acc ccg aca gaa gct gag 144 Page 470 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Gly Pro Val Met Arg Ser Leu Gly Gln Thr Pro Thr Glu Ala Glu 35 40 45 ctt cag gac atg atc aac gaa gtt gac gca gat ggt aac gga ccc atc 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Pro Ile 50 55 60 gat ttt cct gag ttc ttg acc ctt atg gct agg aaa atg aag gac ccg 240 Asp Phe Pro Glu Phe Leu Thr Leu Met Ala Arg Lys Met Lys Asp Pro 65 70 75 80 gac ttt ggg ggg gaa ctc aag gaa gcg ttc aga gtt ttt gat aaa gcc 288 Asp Phe Gly Gly Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Ala 85 90 95 cag aac ggt ttc att tct gct gct gag ttg aga cat gtg atg acg aat 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 ctc ggc gag aag cta act gat gag gaa gtt gat gag atg att aag gaa 384 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Lys Glu 115 120 125 gct gat gtt gat ggt gat ggt cag att aac tat gaa gag ttc gtc aag 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 gtt atg atg gcc aag tgg ggc cac aac cta ctt gtt act tcc cct ctt 480 Val Met Met Ala Lys Trp Gly His Asn Leu Leu Val Thr Ser Pro Leu 145 150 155 160 ttt att atg taa 492 Phe Ile Met <210> 351 <211> 163 <212> PRT <213> Brassica napus <400> 351 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Phe Gly Phe Lys Glu Ala 1 5 10 15 Phe Ser Phe Phe Asp Lys Asp Gly Asp Gly Cys Ile Pro Thr Arg Glu 20 25 30 Phe Gly Pro Val Met Arg Ser Leu Gly Gln Thr Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Pro Ile 50 55 60 Asp Phe Pro Glu Phe Leu Thr Leu Met Ala Arg Lys Met Lys Asp Pro 65 70 75 80 Asp Phe Gly Gly Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Ala 85 90 95 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Lys Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Val Met Met Ala Lys Trp Gly His Asn Leu Leu Val Thr Ser Pro Leu 145 150 155 160 Phe Ile Met <210> 352 <211> 597 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(597) <400> 352 atg agt gct tcg agg ttt atc aag tgt gtc acc gtc ggc gac ggc gct 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala Page 471 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 gtc gga aag act tgt ctg ctc atc tcc tac act agc aac act ttc ccc 96 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gac tat gtg cca act gtg ttt gat aat ttc agc gcg aat gtg att 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Ile 35 40 45 gtg gat ggg aac act atc aac ttg gga ttg tgg gat act gca ggg caa 192 Val Asp Gly Asn Thr Ile Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gag gac tac aat aga cta aga cca ttg agc tat cgc ggc gca gat gtc 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc tta ctc gct ttc tcc ctt gtc agc aaa gct agc tat gaa aat gtt 288 Phe Leu Leu Ala Phe Ser Leu Val Ser Lys Ala Ser Tyr Glu Asn Val 85 90 95 tct aaa aag tgg gta cct gaa ctg aga cat tat gct cct ggt gtt cca 336 Ser Lys Lys Trp Val Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 atc atc ctc gtc gga acc aag ctt gat ctt cga gat gac aag caa ttc 384 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttt gtt gag cac cct ggt gct gtg cct atc tct act gct cag ggt gaa 432 Phe Val Glu His Pro Gly Ala Val Pro Ile Ser Thr Ala Gln Gly Glu 130 135 140 gaa ctg aag aag gtg att ggg gca cct gct tat att gaa tgc agt gca 480 Glu Leu Lys Lys Val Ile Gly Ala Pro Ala Tyr Ile Glu Cys Ser Ala 145 150 155 160 aaa aca caa cag aat gta aaa gcg gtg ttt gat gcg gct atc aag gta 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gtt ctc caa cca ccc aaa aac aag aag agg aag aag aga aag tct cag 576 Val Leu Gln Pro Pro Lys Asn Lys Lys Arg Lys Lys Arg Lys Ser Gln 180 185 190 aaa gct tgt tct ata ttg tga 597 Lys Ala Cys Ser Ile Leu 195 <210> 353 <211> 198 <212> PRT <213> Brassica napus <400> 353 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Ile 35 40 45 Val Asp Gly Asn Thr Ile Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Leu Leu Ala Phe Ser Leu Val Ser Lys Ala Ser Tyr Glu Asn Val 85 90 95 Ser Lys Lys Trp Val Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Val Glu His Pro Gly Ala Val Pro Ile Ser Thr Ala Gln Gly Glu 130 135 140 Glu Leu Lys Lys Val Ile Gly Ala Pro Ala Tyr Ile Glu Cys Ser Ala 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Val Leu Gln Pro Pro Lys Asn Lys Lys Arg Lys Lys Arg Lys Ser Gln 180 185 190 Page 472 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Ala Cys Ser Ile Leu 195 <210> 354 <211> 450 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(450) <400> 354 atg gcg gac cag cta acc gat gac cag atc tcc gag ttc aag gaa gcc 48 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 ttc agc cta ttc gac aag gac gga gat ggc tgc atc acc aca aag gag 96 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 ctc ggg acg gtg atg aga tca ctt ggg caa aac cct aca gaa gct gag 144 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 ctc caa gac atg atc aac gag gtt gac gca gac ggg aat gga acg ata 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 gat ttc ccg gag ttt ctg aac cta atg gcc cgc aag atg aag gac act 240 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 gat tca gag gaa gag ctt aaa gaa gcc ttc agg gtt ttt gac aag gac 288 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 cag aac ggt ttc atc tcc gcg gct gag ctc cgc cac gtg atg aca aat 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 ctt ggg gag aag cta act gac gaa gaa gtg gat gag atg atc cga gag 384 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 gct gac gtg gat ggt gat ggt cag atc aac tat gat gag ttc gtt aaa 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Asp Glu Phe Val Lys 130 135 140 gtt atg atg gca aag tga 450 Val Met Met Ala Lys 145 <210> 355 <211> 149 <212> PRT <213> Brassica napus <400> 355 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Asp Glu Phe Val Lys 130 135 140 Page 473 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Met Met Ala Lys 145 <210> 356 <211> 483 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(483) <400> 356 atg ata cat ttt gtg ctt ctc gtt agc cgc caa gga aaa gtc agg ctc 48 Met Ile His Phe Val Leu Leu Val Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 acc aaa tgg tac tcg cct tat acg cag aag gaa aga tct aag gtt ata 96 Thr Lys Trp Tyr Ser Pro Tyr Thr Gln Lys Glu Arg Ser Lys Val Ile 20 25 30 cgt gag ctc agt gga gtg att ctg aac cga ggt ccc aag ctc tgc aac 144 Arg Glu Leu Ser Gly Val Ile Leu Asn Arg Gly Pro Lys Leu Cys Asn 35 40 45 ttt atc gag tgg aga gga tac aaa gtc gtc tac aaa aga tac gcg agc 192 Phe Ile Glu Trp Arg Gly Tyr Lys Val Val Tyr Lys Arg Tyr Ala Ser 50 55 60 ctc tac ttc tgt atg tgc att gat gcg gag gat aac gag ttg gag gtc 240 Leu Tyr Phe Cys Met Cys Ile Asp Ala Glu Asp Asn Glu Leu Glu Val 65 70 75 80 ctt gag atc att cat cac tac gtt gag atc ctc gac cgc tat ttc gga 288 Leu Glu Ile Ile His His Tyr Val Glu Ile Leu Asp Arg Tyr Phe Gly 85 90 95 agt gtg tgt gag ctc gat ttg att ttt cac ttc cac aag gcg tat tac 336 Ser Val Cys Glu Leu Asp Leu Ile Phe His Phe His Lys Ala Tyr Tyr 100 105 110 ata ttg gac gag ctt ttg att gcc ggt gag ctc caa gag tca agc aag 384 Ile Leu Asp Glu Leu Leu Ile Ala Gly Glu Leu Gln Glu Ser Ser Lys 115 120 125 aaa aca gtt gcc agg att atc tct gct cag gat caa atg gtg gaa gct 432 Lys Thr Val Ala Arg Ile Ile Ser Ala Gln Asp Gln Met Val Glu Ala 130 135 140 gca aaa gag gag gct ggt tcc att agc tac atc atc gct cag act act 480 Ala Lys Glu Glu Ala Gly Ser Ile Ser Tyr Ile Ile Ala Gln Thr Thr 145 150 155 160 taa 483 <210> 357 <211> 160 <212> PRT <213> Brassica napus <400> 357 Met Ile His Phe Val Leu Leu Val Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 Thr Lys Trp Tyr Ser Pro Tyr Thr Gln Lys Glu Arg Ser Lys Val Ile 20 25 30 Arg Glu Leu Ser Gly Val Ile Leu Asn Arg Gly Pro Lys Leu Cys Asn 35 40 45 Phe Ile Glu Trp Arg Gly Tyr Lys Val Val Tyr Lys Arg Tyr Ala Ser 50 55 60 Leu Tyr Phe Cys Met Cys Ile Asp Ala Glu Asp Asn Glu Leu Glu Val 65 70 75 80 Leu Glu Ile Ile His His Tyr Val Glu Ile Leu Asp Arg Tyr Phe Gly 85 90 95 Ser Val Cys Glu Leu Asp Leu Ile Phe His Phe His Lys Ala Tyr Tyr 100 105 110 Ile Leu Asp Glu Leu Leu Ile Ala Gly Glu Leu Gln Glu Ser Ser Lys Page 474 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 115 120 125 Lys Thr Val Ala Arg Ile Ile Ser Ala Gln Asp Gln Met Val Glu Ala 130 135 140 Ala Lys Glu Glu Ala Gly Ser Ile Ser Tyr Ile Ile Ala Gln Thr Thr 145 150 155 160 <210> 358 <211> 1083 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1083) <400> 358 atg gcg aaa tct cca gag aca gag cat ccg aac aaa gcc ttt ggt tgg 48 Met Ala Lys Ser Pro Glu Thr Glu His Pro Asn Lys Ala Phe Gly Trp 1 5 10 15 gct gcc aaa gac aaa tct ggt gta ctc tct cct ttc cat ttc tcc aga 96 Ala Ala Lys Asp Lys Ser Gly Val Leu Ser Pro Phe His Phe Ser Arg 20 25 30 aga gac aat ggt gac aat gat gtg aca gtg aaa atc ttg tac tgt gga 144 Arg Asp Asn Gly Asp Asn Asp Val Thr Val Lys Ile Leu Tyr Cys Gly 35 40 45 gtg tgc cac act gat tta cat acc atc aaa aac gac tgg ggt ttc tcc 192 Val Cys His Thr Asp Leu His Thr Ile Lys Asn Asp Trp Gly Phe Ser 50 55 60 tat tat cct gta gtt ccc ggg cat gaa ata gtt gga ata gct aca aaa 240 Tyr Tyr Pro Val Val Pro Gly His Glu Ile Val Gly Ile Ala Thr Lys 65 70 75 80 gtt ggc aaa aac gtg act aaa ttc aga gaa gga gac cgt gtt gga gta 288 Val Gly Lys Asn Val Thr Lys Phe Arg Glu Gly Asp Arg Val Gly Val 85 90 95 gga gtg atc act ggt tct tgc cag tct tgc gaa tct tgt aac caa gat 336 Gly Val Ile Thr Gly Ser Cys Gln Ser Cys Glu Ser Cys Asn Gln Asp 100 105 110 ctt gaa aac tac tgt ccc caa atg tct ttc acc tac aac tcc ata gga 384 Leu Glu Asn Tyr Cys Pro Gln Met Ser Phe Thr Tyr Asn Ser Ile Gly 115 120 125 tcc gat gga acc aag acc tac ggt gga tat tcg gag tcc att gtg gtc 432 Ser Asp Gly Thr Lys Thr Tyr Gly Gly Tyr Ser Glu Ser Ile Val Val 130 135 140 gat caa cgt ttt gtc tta cag ttt ccc gag gga ttg cct agc gat tcg 480 Asp Gln Arg Phe Val Leu Gln Phe Pro Glu Gly Leu Pro Ser Asp Ser 145 150 155 160 ggt gcc ccc ttg ctg tgt gct ggt atc act gtg tat agt cca atg aag 528 Gly Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Ser Pro Met Lys 165 170 175 tac tat ggt atg acc gag cca ggg aag cat ttg ggc gtg gct gga ctt 576 Tyr Tyr Gly Met Thr Glu Pro Gly Lys His Leu Gly Val Ala Gly Leu 180 185 190 ggt ggg ctt ggt cat gtt gct gtc aag att ggt aaa gcc ttt ggt ttg 624 Gly Gly Leu Gly His Val Ala Val Lys Ile Gly Lys Ala Phe Gly Leu 195 200 205 aaa gtt act gtg att agt tct tct cct agt aaa gaa gac gaa gct att 672 Lys Val Thr Val Ile Ser Ser Ser Pro Ser Lys Glu Asp Glu Ala Ile 210 215 220 aat cga ctt ggt gct gat tcg ttt ctt gtc tca tct gat cct cag aag 720 Asn Arg Leu Gly Ala Asp Ser Phe Leu Val Ser Ser Asp Pro Gln Lys 225 230 235 240 atg aag gct gca att gga act atg gac tat att atc gat acg gta tca 768 Met Lys Ala Ala Ile Gly Thr Met Asp Tyr Ile Ile Asp Thr Val Ser 245 250 255 gca gta cat gct ctg ttt cca ttg ctt ggt tta ctc aaa gtc aat gga 816 Ala Val His Ala Leu Phe Pro Leu Leu Gly Leu Leu Lys Val Asn Gly 260 265 270 aag ctt gtc acg tta ggc tta cct gag aag cct ctt gag cta cca atc 864 Page 475 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Leu Val Thr Leu Gly Leu Pro Glu Lys Pro Leu Glu Leu Pro Ile 275 280 285 ttc cct ctt gtt ctc gga aga aaa atg gtg gga gga agt gac att gga 912 Phe Pro Leu Val Leu Gly Arg Lys Met Val Gly Gly Ser Asp Ile Gly 290 295 300 ggg atg aag gag aca caa gag atg ctt gag ttc tgc gct aag cat aac 960 Gly Met Lys Glu Thr Gln Glu Met Leu Glu Phe Cys Ala Lys His Asn 305 310 315 320 ata acg gca gat att gag ctg atc aag atg gat gag att aac act gcg 1008 Ile Thr Ala Asp Ile Glu Leu Ile Lys Met Asp Glu Ile Asn Thr Ala 325 330 335 atg gag agg ctt gct aag tct gat gtt agg tac agg ttc gtg atc gac 1056 Met Glu Arg Leu Ala Lys Ser Asp Val Arg Tyr Arg Phe Val Ile Asp 340 345 350 gtg gct aac tcc ttg agc cct cca tga 1083 Val Ala Asn Ser Leu Ser Pro Pro 355 360 <210> 359 <211> 360 <212> PRT <213> Brassica napus <400> 359 Met Ala Lys Ser Pro Glu Thr Glu His Pro Asn Lys Ala Phe Gly Trp 1 5 10 15 Ala Ala Lys Asp Lys Ser Gly Val Leu Ser Pro Phe His Phe Ser Arg 20 25 30 Arg Asp Asn Gly Asp Asn Asp Val Thr Val Lys Ile Leu Tyr Cys Gly 35 40 45 Val Cys His Thr Asp Leu His Thr Ile Lys Asn Asp Trp Gly Phe Ser 50 55 60 Tyr Tyr Pro Val Val Pro Gly His Glu Ile Val Gly Ile Ala Thr Lys 65 70 75 80 Val Gly Lys Asn Val Thr Lys Phe Arg Glu Gly Asp Arg Val Gly Val 85 90 95 Gly Val Ile Thr Gly Ser Cys Gln Ser Cys Glu Ser Cys Asn Gln Asp 100 105 110 Leu Glu Asn Tyr Cys Pro Gln Met Ser Phe Thr Tyr Asn Ser Ile Gly 115 120 125 Ser Asp Gly Thr Lys Thr Tyr Gly Gly Tyr Ser Glu Ser Ile Val Val 130 135 140 Asp Gln Arg Phe Val Leu Gln Phe Pro Glu Gly Leu Pro Ser Asp Ser 145 150 155 160 Gly Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Ser Pro Met Lys 165 170 175 Tyr Tyr Gly Met Thr Glu Pro Gly Lys His Leu Gly Val Ala Gly Leu 180 185 190 Gly Gly Leu Gly His Val Ala Val Lys Ile Gly Lys Ala Phe Gly Leu 195 200 205 Lys Val Thr Val Ile Ser Ser Ser Pro Ser Lys Glu Asp Glu Ala Ile 210 215 220 Asn Arg Leu Gly Ala Asp Ser Phe Leu Val Ser Ser Asp Pro Gln Lys 225 230 235 240 Met Lys Ala Ala Ile Gly Thr Met Asp Tyr Ile Ile Asp Thr Val Ser 245 250 255 Ala Val His Ala Leu Phe Pro Leu Leu Gly Leu Leu Lys Val Asn Gly 260 265 270 Lys Leu Val Thr Leu Gly Leu Pro Glu Lys Pro Leu Glu Leu Pro Ile 275 280 285 Phe Pro Leu Val Leu Gly Arg Lys Met Val Gly Gly Ser Asp Ile Gly 290 295 300 Gly Met Lys Glu Thr Gln Glu Met Leu Glu Phe Cys Ala Lys His Asn 305 310 315 320 Ile Thr Ala Asp Ile Glu Leu Ile Lys Met Asp Glu Ile Asn Thr Ala 325 330 335 Met Glu Arg Leu Ala Lys Ser Asp Val Arg Tyr Arg Phe Val Ile Asp 340 345 350 Page 476 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Val Ala Asn Ser Leu Ser Pro Pro 355 360 <210> 360 <211> 366 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(366) <400> 360 atg atc cga ttc ata tta ttg cag aac aga caa ggg aag act cgt ctt 48 Met Ile Arg Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 gcc aag tac tat gtc cct ctc gaa gaa tcg gag aaa cac aaa gtc gaa 96 Ala Lys Tyr Tyr Val Pro Leu Glu Glu Ser Glu Lys His Lys Val Glu 20 25 30 tac gag gtt cat agg tta gtg gtg aac cgc gat gcc aag ttc acc aat 144 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Ala Lys Phe Thr Asn 35 40 45 ttc gtt gag ttt aga aca cac aag gtg ata tac agg cgt tac gct gga 192 Phe Val Glu Phe Arg Thr His Lys Val Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 ctg ttt ttc tcc gtg tgc gtg gac ata acg gac aat gag ttg gct tac 240 Leu Phe Phe Ser Val Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 ctt gag tgc atc cat ttg ttt gtg gag att ttg gat cac ttc ttc agc 288 Leu Glu Cys Ile His Leu Phe Val Glu Ile Leu Asp His Phe Phe Ser 85 90 95 aat gtc tgt gag ctt gat ttg gtc ttc aac ttc cac aag act tcc cca 336 Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe His Lys Thr Ser Pro 100 105 110 tat atg ttt gat ttt aac agg tgt act tga 366 Tyr Met Phe Asp Phe Asn Arg Cys Thr 115 120 <210> 361 <211> 121 <212> PRT <213> Brassica napus <400> 361 Met Ile Arg Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 Ala Lys Tyr Tyr Val Pro Leu Glu Glu Ser Glu Lys His Lys Val Glu 20 25 30 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Ala Lys Phe Thr Asn 35 40 45 Phe Val Glu Phe Arg Thr His Lys Val Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 Leu Phe Phe Ser Val Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 Leu Glu Cys Ile His Leu Phe Val Glu Ile Leu Asp His Phe Phe Ser 85 90 95 Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe His Lys Thr Ser Pro 100 105 110 Tyr Met Phe Asp Phe Asn Arg Cys Thr 115 120 <210> 362 <211> 831 <212> DNA <213> Brassica napus <220> <221> CDS Page 477 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(831) <400> 362 atg gcc tcc ggt tta atc gga aga ttc gtt aga acc aat ccg tcg cga 48 Met Ala Ser Gly Leu Ile Gly Arg Phe Val Arg Thr Asn Pro Ser Arg 1 5 10 15 tta acc acc gcg gcg agg cta atc ccg tcg cga tgc aca gct tcc tca 96 Leu Thr Thr Ala Ala Arg Leu Ile Pro Ser Arg Cys Thr Ala Ser Ser 20 25 30 acg gat aac ggc ggc ggc ggc ggc ggc aaa gca tcg aac ctg aag acg 144 Thr Asp Asn Gly Gly Gly Gly Gly Gly Lys Ala Ser Asn Leu Lys Thr 35 40 45 ttc cag atc tac cga tgg aac ccc gac aac ccc agc aag ccc gag ctc 192 Phe Gln Ile Tyr Arg Trp Asn Pro Asp Asn Pro Ser Lys Pro Glu Leu 50 55 60 caa gac tac cag atc gac ctc aag gac tgt ggc ccg atg gtc ctc gac 240 Gln Asp Tyr Gln Ile Asp Leu Lys Asp Cys Gly Pro Met Val Leu Asp 65 70 75 80 gcc cta atc aag atc aag aac gag atg gat ccc tcc ctc acc ttc cgc 288 Ala Leu Ile Lys Ile Lys Asn Glu Met Asp Pro Ser Leu Thr Phe Arg 85 90 95 cgc tcg tgc cga gaa ggg atc tgc ggc tcg tgc gcg atg aac atc gac 336 Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser Cys Ala Met Asn Ile Asp 100 105 110 ggg tgc aac ggg ctc gcg tgc ttg acg aag atc gag gag gga tcc aag 384 Gly Cys Asn Gly Leu Ala Cys Leu Thr Lys Ile Glu Glu Gly Ser Lys 115 120 125 gag acg acg atc act ccc ttg ccg cat atg ttc gtg atc aag gat ctg 432 Glu Thr Thr Ile Thr Pro Leu Pro His Met Phe Val Ile Lys Asp Leu 130 135 140 gtg gtg gac atg acg aat ttt tat aat cag tat aag agt atc gag ccg 480 Val Val Asp Met Thr Asn Phe Tyr Asn Gln Tyr Lys Ser Ile Glu Pro 145 150 155 160 tgg ctg aag agg aag agt ccg gcg tct gag cct ggg aag gag att ctg 528 Trp Leu Lys Arg Lys Ser Pro Ala Ser Glu Pro Gly Lys Glu Ile Leu 165 170 175 cag agt aag aag gat agg gcg aag ctt gat ggg atg tat gag tgt att 576 Gln Ser Lys Lys Asp Arg Ala Lys Leu Asp Gly Met Tyr Glu Cys Ile 180 185 190 ctt tgt gct tgt tgt agc acg tcg tgt cct agt tat tgg tgg aac ccc 624 Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Pro 195 200 205 gag tct tat ctt ggc cct gct gct ttg cta cat gcc aac agg tgg ata 672 Glu Ser Tyr Leu Gly Pro Ala Ala Leu Leu His Ala Asn Arg Trp Ile 210 215 220 agc gac agt cgt gat gag tac act aag gag aga ctt gag gct att gac 720 Ser Asp Ser Arg Asp Glu Tyr Thr Lys Glu Arg Leu Glu Ala Ile Asp 225 230 235 240 gac gag ttc aag ctt tac cgt tgc cat aca atc ttg aac tgc gcc cgt 768 Asp Glu Phe Lys Leu Tyr Arg Cys His Thr Ile Leu Asn Cys Ala Arg 245 250 255 gcc tgt cca aag ggt ttg aac cca ggc aaa cag atc gcg cat atc aag 816 Ala Cys Pro Lys Gly Leu Asn Pro Gly Lys Gln Ile Ala His Ile Lys 260 265 270 caa ctt cag cgc tga 831 Gln Leu Gln Arg 275 <210> 363 <211> 276 <212> PRT <213> Brassica napus <400> 363 Met Ala Ser Gly Leu Ile Gly Arg Phe Val Arg Thr Asn Pro Ser Arg 1 5 10 15 Leu Thr Thr Ala Ala Arg Leu Ile Pro Ser Arg Cys Thr Ala Ser Ser 20 25 30 Page 478 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Asp Asn Gly Gly Gly Gly Gly Gly Lys Ala Ser Asn Leu Lys Thr 35 40 45 Phe Gln Ile Tyr Arg Trp Asn Pro Asp Asn Pro Ser Lys Pro Glu Leu 50 55 60 Gln Asp Tyr Gln Ile Asp Leu Lys Asp Cys Gly Pro Met Val Leu Asp 65 70 75 80 Ala Leu Ile Lys Ile Lys Asn Glu Met Asp Pro Ser Leu Thr Phe Arg 85 90 95 Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser Cys Ala Met Asn Ile Asp 100 105 110 Gly Cys Asn Gly Leu Ala Cys Leu Thr Lys Ile Glu Glu Gly Ser Lys 115 120 125 Glu Thr Thr Ile Thr Pro Leu Pro His Met Phe Val Ile Lys Asp Leu 130 135 140 Val Val Asp Met Thr Asn Phe Tyr Asn Gln Tyr Lys Ser Ile Glu Pro 145 150 155 160 Trp Leu Lys Arg Lys Ser Pro Ala Ser Glu Pro Gly Lys Glu Ile Leu 165 170 175 Gln Ser Lys Lys Asp Arg Ala Lys Leu Asp Gly Met Tyr Glu Cys Ile 180 185 190 Leu Cys Ala Cys Cys Ser Thr Ser Cys Pro Ser Tyr Trp Trp Asn Pro 195 200 205 Glu Ser Tyr Leu Gly Pro Ala Ala Leu Leu His Ala Asn Arg Trp Ile 210 215 220 Ser Asp Ser Arg Asp Glu Tyr Thr Lys Glu Arg Leu Glu Ala Ile Asp 225 230 235 240 Asp Glu Phe Lys Leu Tyr Arg Cys His Thr Ile Leu Asn Cys Ala Arg 245 250 255 Ala Cys Pro Lys Gly Leu Asn Pro Gly Lys Gln Ile Ala His Ile Lys 260 265 270 Gln Leu Gln Arg 275 <210> 364 <211> 951 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(951) <400> 364 atg ttg ggg gat gct ttt ctt cac caa ttg cca cat gct ttt ggt ggt 48 Met Leu Gly Asp Ala Phe Leu His Gln Leu Pro His Ala Phe Gly Gly 1 5 10 15 ggt cac tct cat tcg cat gat cac cat gag agt cat gac cat cat gat 96 Gly His Ser His Ser His Asp His His Glu Ser His Asp His His Asp 20 25 30 cat tct cac tct cat tcg gat tcg cct tca cat tca cat tct ata caa 144 His Ser His Ser His Ser Asp Ser Pro Ser His Ser His Ser Ile Gln 35 40 45 gat ctg tct gtt gga ctg tct gtt ctt gct ggg att gtg gtc ttc ctt 192 Asp Leu Ser Val Gly Leu Ser Val Leu Ala Gly Ile Val Val Phe Leu 50 55 60 ctt gtg gag aaa ttg gtg cgg tac gtc gaa gaa aac tcg tct gga tcc 240 Leu Val Glu Lys Leu Val Arg Tyr Val Glu Glu Asn Ser Ser Gly Ser 65 70 75 80 aat gct tgg ggt cac cat cac cac cac cac cat gca gga ggc agt aag 288 Asn Ala Trp Gly His His His His His His His Ala Gly Gly Ser Lys 85 90 95 aaa ctg aag gat gag gac gat cat aac aac gcg gac aaa cag tgt ccc 336 Lys Leu Lys Asp Glu Asp Asp His Asn Asn Ala Asp Lys Gln Cys Pro 100 105 110 tct gat gca act gaa aat tca tca gaa aaa gtc tct aaa gat aaa tct 384 Ser Asp Ala Thr Glu Asn Ser Ser Glu Lys Val Ser Lys Asp Lys Ser 115 120 125 ctc cgt aag aga aag act tct gct att gat ggt gtg gat aaa tca aac 432 Page 479 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Arg Lys Arg Lys Thr Ser Ala Ile Asp Gly Val Asp Lys Ser Asn 130 135 140 tca ggc tca gaa act atc tcc aat gga aaa ttg gac aaa cct gaa cag 480 Ser Gly Ser Glu Thr Ile Ser Asn Gly Lys Leu Asp Lys Pro Glu Gln 145 150 155 160 gcg gag aag aac tca agc cta gta ttt ggt tac ctc aac ttg ttc tct 528 Ala Glu Lys Asn Ser Ser Leu Val Phe Gly Tyr Leu Asn Leu Phe Ser 165 170 175 gat ggt gtt cac aat ttt act gat gga atg gcg tta gga agt gcg ttt 576 Asp Gly Val His Asn Phe Thr Asp Gly Met Ala Leu Gly Ser Ala Phe 180 185 190 ctc atc tac gga tca gtt ggt gga tgg tca aga acc atg ttc ttg ctt 624 Leu Ile Tyr Gly Ser Val Gly Gly Trp Ser Arg Thr Met Phe Leu Leu 195 200 205 gcg cac gag ctt ccc caa gag ata ggt gat ttt ggg att cta gtg agg 672 Ala His Glu Leu Pro Gln Glu Ile Gly Asp Phe Gly Ile Leu Val Arg 210 215 220 tca ggc ttc act gta aca aag gca ctc ttc ttc aac ttc ctc tct gca 720 Ser Gly Phe Thr Val Thr Lys Ala Leu Phe Phe Asn Phe Leu Ser Ala 225 230 235 240 ctc gtt gca ctt gca gga act tca ttg gtt ctg gtc tgg gga gat gaa 768 Leu Val Ala Leu Ala Gly Thr Ser Leu Val Leu Val Trp Gly Asp Glu 245 250 255 ccg gga cag tca tca ttg att gag gga ttc aca gcg gga gga ttc ata 816 Pro Gly Gln Ser Ser Leu Ile Glu Gly Phe Thr Ala Gly Gly Phe Ile 260 265 270 tac ata gcg gtt gca ggt gtt ctt gcg gag atg aac aac aac tcg gga 864 Tyr Ile Ala Val Ala Gly Val Leu Ala Glu Met Asn Asn Asn Ser Gly 275 280 285 aaa tcg aca gtt aaa aac agt gtg tgc cat ttg ata tcg ttg atg ctt 912 Lys Ser Thr Val Lys Asn Ser Val Cys His Leu Ile Ser Leu Met Leu 290 295 300 ggc atg agt gtt gct ctt gtc atc tct ctt ctt gaa tga 951 Gly Met Ser Val Ala Leu Val Ile Ser Leu Leu Glu 305 310 315 <210> 365 <211> 316 <212> PRT <213> Brassica napus <400> 365 Met Leu Gly Asp Ala Phe Leu His Gln Leu Pro His Ala Phe Gly Gly 1 5 10 15 Gly His Ser His Ser His Asp His His Glu Ser His Asp His His Asp 20 25 30 His Ser His Ser His Ser Asp Ser Pro Ser His Ser His Ser Ile Gln 35 40 45 Asp Leu Ser Val Gly Leu Ser Val Leu Ala Gly Ile Val Val Phe Leu 50 55 60 Leu Val Glu Lys Leu Val Arg Tyr Val Glu Glu Asn Ser Ser Gly Ser 65 70 75 80 Asn Ala Trp Gly His His His His His His His Ala Gly Gly Ser Lys 85 90 95 Lys Leu Lys Asp Glu Asp Asp His Asn Asn Ala Asp Lys Gln Cys Pro 100 105 110 Ser Asp Ala Thr Glu Asn Ser Ser Glu Lys Val Ser Lys Asp Lys Ser 115 120 125 Leu Arg Lys Arg Lys Thr Ser Ala Ile Asp Gly Val Asp Lys Ser Asn 130 135 140 Ser Gly Ser Glu Thr Ile Ser Asn Gly Lys Leu Asp Lys Pro Glu Gln 145 150 155 160 Ala Glu Lys Asn Ser Ser Leu Val Phe Gly Tyr Leu Asn Leu Phe Ser 165 170 175 Asp Gly Val His Asn Phe Thr Asp Gly Met Ala Leu Gly Ser Ala Phe 180 185 190 Leu Ile Tyr Gly Ser Val Gly Gly Trp Ser Arg Thr Met Phe Leu Leu 195 200 205 Page 480 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala His Glu Leu Pro Gln Glu Ile Gly Asp Phe Gly Ile Leu Val Arg 210 215 220 Ser Gly Phe Thr Val Thr Lys Ala Leu Phe Phe Asn Phe Leu Ser Ala 225 230 235 240 Leu Val Ala Leu Ala Gly Thr Ser Leu Val Leu Val Trp Gly Asp Glu 245 250 255 Pro Gly Gln Ser Ser Leu Ile Glu Gly Phe Thr Ala Gly Gly Phe Ile 260 265 270 Tyr Ile Ala Val Ala Gly Val Leu Ala Glu Met Asn Asn Asn Ser Gly 275 280 285 Lys Ser Thr Val Lys Asn Ser Val Cys His Leu Ile Ser Leu Met Leu 290 295 300 Gly Met Ser Val Ala Leu Val Ile Ser Leu Leu Glu 305 310 315 <210> 366 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 366 atg gct cgt acg aag cag act gcg agg aaa tcg aca gga gga aaa gct 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccg agg aag caa ctc gcc acc aag gct gcg agg aaa tct gca ccg acc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 acc gga gga gtc aag aag cct cac cgt tac cgt ccc gga acc gtc gct 144 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 ctc cgt gag att cgt aag tac cag aag agc act gag ttg ctg atc cgt 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aaa ctt ccc ttc cag cgt ctt gtt cgt gaa atc gct cag gat ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acg gat ctg aga ttc cag agc cac gca gtg ttg gct ctc cag gaa gct 288 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 gcg gag gcg tat ttg gtg ggt ttg ttc gaa gac acg aat ctc tgt gcc 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gcc aag aga gtc acc atc atg ccc aaa gac att caa ttg gct 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 agg cgc att cgt gga gag cgt gct tag 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 367 <211> 136 <212> PRT <213> Brassica napus <400> 367 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Page 481 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 368 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 368 atg gct cgt acc aag caa acc gct agg aaa tcc acc gga ggc aaa gca 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 cca agg aag cag ctc gcg acg aaa gcc gca aga aaa tcc gct ccg gcc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acc ggc gga gtg aag aag ccg cac aga ttc cgt ccc gga acg gtg gcg 144 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 ttg agg gag atc agg aag tac cag aag agc acg gag ctt ctg atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctc ccc ttc cag cgt ctt gtc cgt gag atc gct cag gat ttc aaa 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acc gat ctg agg ttc cag agc agc gcc gtc gca gct ctt caa gaa gca 288 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gcc gaa gct tac ctt gtt ggt ttg ttc gaa gac acg aat ctc tgc gcg 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gcg aag aga gta aca atc atg cca aag gac atc cag ctg gca 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 aga aga atc aga ggc gaa aga gct tga 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 369 <211> 136 <212> PRT <213> Brassica napus <400> 369 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Page 482 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 370 <211> 1185 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1185) <400> 370 atg cct ccg aaa gca aaa gca aag gat gca ggt ccc gtg gag agg cct 48 Met Pro Pro Lys Ala Lys Ala Lys Asp Ala Gly Pro Val Glu Arg Pro 1 5 10 15 att ctt ggc cgc ttc tcg tct cac ctc aag atc gga atc gtg ggg ctg 96 Ile Leu Gly Arg Phe Ser Ser His Leu Lys Ile Gly Ile Val Gly Leu 20 25 30 cca aac gtg ggg aag tct aca ctt ttc aac act ctt acg aag ctt tcg 144 Pro Asn Val Gly Lys Ser Thr Leu Phe Asn Thr Leu Thr Lys Leu Ser 35 40 45 att cca gct gag aac ttc ccc ttc tgt acc att gag cct aac gag gcg 192 Ile Pro Ala Glu Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Glu Ala 50 55 60 cgt gtg aat atc ccc gac gag agg ttc gat tgg ctt tgc cag tta tac 240 Arg Val Asn Ile Pro Asp Glu Arg Phe Asp Trp Leu Cys Gln Leu Tyr 65 70 75 80 aag cct aag agt gag att cca gcg ttc ttg gaa ata cac gac att gct 288 Lys Pro Lys Ser Glu Ile Pro Ala Phe Leu Glu Ile His Asp Ile Ala 85 90 95 ggg ctt gtt aga ggc gct cat gaa gga cag gga ctt ggg aac aac ttc 336 Gly Leu Val Arg Gly Ala His Glu Gly Gln Gly Leu Gly Asn Asn Phe 100 105 110 ttg tct cac att cgt gct gtt gat gga atc ttc cat gtt tta cgt gcg 384 Leu Ser His Ile Arg Ala Val Asp Gly Ile Phe His Val Leu Arg Ala 115 120 125 ttt gaa gat cct gat att att cat gtt gat gac att gtg gat cct gtt 432 Phe Glu Asp Pro Asp Ile Ile His Val Asp Asp Ile Val Asp Pro Val 130 135 140 aga gat ttg gag acc att act gaa gag ttg cga ctt aag gat att gaa 480 Arg Asp Leu Glu Thr Ile Thr Glu Glu Leu Arg Leu Lys Asp Ile Glu 145 150 155 160 ttc att aaa aag aag att gaa gat gtc gag aag agc atg aag agg agc 528 Phe Ile Lys Lys Lys Ile Glu Asp Val Glu Lys Ser Met Lys Arg Ser 165 170 175 aat gac aag gcc ctc aaa gtt gaa ctt gag ctc ttg cta aag gta aaa 576 Asn Asp Lys Ala Leu Lys Val Glu Leu Glu Leu Leu Leu Lys Val Lys 180 185 190 gct tgg ctg gaa gaa gga aag gat gtc cgt ttt gga gac tgg aaa gca 624 Ala Trp Leu Glu Glu Gly Lys Asp Val Arg Phe Gly Asp Trp Lys Ala 195 200 205 gct gat atc gag att ttg aac act ttc cag ttg ctt tcc gct aag ccc 672 Ala Asp Ile Glu Ile Leu Asn Thr Phe Gln Leu Leu Ser Ala Lys Pro 210 215 220 gtt gtt tac ttg att aac atg aat gag aga gac tac cag agg aag aaa 720 Val Val Tyr Leu Ile Asn Met Asn Glu Arg Asp Tyr Gln Arg Lys Lys 225 230 235 240 aac aag ttc ttg ccc aag att cat gct tgg gtt caa gag cac ggt ggt 768 Asn Lys Phe Leu Pro Lys Ile His Ala Trp Val Gln Glu His Gly Gly 245 250 255 gat act atg att cct ttc agt ggt gtt ttt gaa agg agt ctc gct gat 816 Asp Thr Met Ile Pro Phe Ser Gly Val Phe Glu Arg Ser Leu Ala Asp 260 265 270 atg ctc ccc gac gaa gca gca aag tat tgt gag gag aac aaa ctg caa 864 Met Leu Pro Asp Glu Ala Ala Lys Tyr Cys Glu Glu Asn Lys Leu Gln Page 483 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 275 280 285 agt gct ctt ccg agg atc atc aaa acg gga ttt tca gcc att aat ctc 912 Ser Ala Leu Pro Arg Ile Ile Lys Thr Gly Phe Ser Ala Ile Asn Leu 290 295 300 ata tat ttc ttt act gca gga cct gat gag gta aag tgc tgg caa ata 960 Ile Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Lys Cys Trp Gln Ile 305 310 315 320 aga cgt cag tca aag gct cct caa gct gca ggc gcc att cat act gat 1008 Arg Arg Gln Ser Lys Ala Pro Gln Ala Ala Gly Ala Ile His Thr Asp 325 330 335 ttt gag aga ggg ttt att tgt gct gag gtc atg aaa ttt gag gat ctc 1056 Phe Glu Arg Gly Phe Ile Cys Ala Glu Val Met Lys Phe Glu Asp Leu 340 345 350 aag gaa ctt ggc aat gaa acc gca gtc aag ggc gca gga aaa tac aga 1104 Lys Glu Leu Gly Asn Glu Thr Ala Val Lys Gly Ala Gly Lys Tyr Arg 355 360 365 cag gag ggg aaa aca tat gtt gtt cag gat gga gat atc att ttc ttc 1152 Gln Glu Gly Lys Thr Tyr Val Val Gln Asp Gly Asp Ile Ile Phe Phe 370 375 380 aag ttc aac gtt tct ggt ggt ggg aag aaa tga 1185 Lys Phe Asn Val Ser Gly Gly Gly Lys Lys 385 390 <210> 371 <211> 394 <212> PRT <213> Brassica napus <400> 371 Met Pro Pro Lys Ala Lys Ala Lys Asp Ala Gly Pro Val Glu Arg Pro 1 5 10 15 Ile Leu Gly Arg Phe Ser Ser His Leu Lys Ile Gly Ile Val Gly Leu 20 25 30 Pro Asn Val Gly Lys Ser Thr Leu Phe Asn Thr Leu Thr Lys Leu Ser 35 40 45 Ile Pro Ala Glu Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Glu Ala 50 55 60 Arg Val Asn Ile Pro Asp Glu Arg Phe Asp Trp Leu Cys Gln Leu Tyr 65 70 75 80 Lys Pro Lys Ser Glu Ile Pro Ala Phe Leu Glu Ile His Asp Ile Ala 85 90 95 Gly Leu Val Arg Gly Ala His Glu Gly Gln Gly Leu Gly Asn Asn Phe 100 105 110 Leu Ser His Ile Arg Ala Val Asp Gly Ile Phe His Val Leu Arg Ala 115 120 125 Phe Glu Asp Pro Asp Ile Ile His Val Asp Asp Ile Val Asp Pro Val 130 135 140 Arg Asp Leu Glu Thr Ile Thr Glu Glu Leu Arg Leu Lys Asp Ile Glu 145 150 155 160 Phe Ile Lys Lys Lys Ile Glu Asp Val Glu Lys Ser Met Lys Arg Ser 165 170 175 Asn Asp Lys Ala Leu Lys Val Glu Leu Glu Leu Leu Leu Lys Val Lys 180 185 190 Ala Trp Leu Glu Glu Gly Lys Asp Val Arg Phe Gly Asp Trp Lys Ala 195 200 205 Ala Asp Ile Glu Ile Leu Asn Thr Phe Gln Leu Leu Ser Ala Lys Pro 210 215 220 Val Val Tyr Leu Ile Asn Met Asn Glu Arg Asp Tyr Gln Arg Lys Lys 225 230 235 240 Asn Lys Phe Leu Pro Lys Ile His Ala Trp Val Gln Glu His Gly Gly 245 250 255 Asp Thr Met Ile Pro Phe Ser Gly Val Phe Glu Arg Ser Leu Ala Asp 260 265 270 Met Leu Pro Asp Glu Ala Ala Lys Tyr Cys Glu Glu Asn Lys Leu Gln 275 280 285 Ser Ala Leu Pro Arg Ile Ile Lys Thr Gly Phe Ser Ala Ile Asn Leu 290 295 300 Ile Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Lys Cys Trp Gln Ile Page 484 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 305 310 315 320 Arg Arg Gln Ser Lys Ala Pro Gln Ala Ala Gly Ala Ile His Thr Asp 325 330 335 Phe Glu Arg Gly Phe Ile Cys Ala Glu Val Met Lys Phe Glu Asp Leu 340 345 350 Lys Glu Leu Gly Asn Glu Thr Ala Val Lys Gly Ala Gly Lys Tyr Arg 355 360 365 Gln Glu Gly Lys Thr Tyr Val Val Gln Asp Gly Asp Ile Ile Phe Phe 370 375 380 Lys Phe Asn Val Ser Gly Gly Gly Lys Lys 385 390 <210> 372 <211> 825 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(825) <400> 372 atg tct cag tca aca gtg gat gtt ccg ccg aag ggt ggg ttc agc ttc 48 Met Ser Gln Ser Thr Val Asp Val Pro Pro Lys Gly Gly Phe Ser Phe 1 5 10 15 gat ctg tgt aag cga aac gat atg ctt ata caa aag ggt ctt aaa gct 96 Asp Leu Cys Lys Arg Asn Asp Met Leu Ile Gln Lys Gly Leu Lys Ala 20 25 30 ccc tcc ttt ttg aag acc ggt acc acc atc gtc ggt ttg atc ttc aag 144 Pro Ser Phe Leu Lys Thr Gly Thr Thr Ile Val Gly Leu Ile Phe Lys 35 40 45 gat ggt gtg ata cta ggt gcg gat acc cga gca act gaa ggg cct att 192 Asp Gly Val Ile Leu Gly Ala Asp Thr Arg Ala Thr Glu Gly Pro Ile 50 55 60 gtt gct gat aag aac tgt gag aaa att cac tac atg gct cct aac att 240 Val Ala Asp Lys Asn Cys Glu Lys Ile His Tyr Met Ala Pro Asn Ile 65 70 75 80 tat tgc tgt ggt gct gga acg gct gct gac act gaa gca gtc act gat 288 Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Glu Ala Val Thr Asp 85 90 95 atg gtc agc tca cag ctg cgg ctg cat cgt tac cag act ggc cga gac 336 Met Val Ser Ser Gln Leu Arg Leu His Arg Tyr Gln Thr Gly Arg Asp 100 105 110 tct cgg gtt atc act gct ttg acc ctt ctc aaa aaa cac ctt ttc agc 384 Ser Arg Val Ile Thr Ala Leu Thr Leu Leu Lys Lys His Leu Phe Ser 115 120 125 tat caa ggt cat gtc tca gct gct ctc gtc ctt ggt gga gtt gat atc 432 Tyr Gln Gly His Val Ser Ala Ala Leu Val Leu Gly Gly Val Asp Ile 130 135 140 aca ggg cct cat ctg cat act ata tac cca cac ggt tca acg gac act 480 Thr Gly Pro His Leu His Thr Ile Tyr Pro His Gly Ser Thr Asp Thr 145 150 155 160 ctg cca ttc gct aca atg ggt tct ggt tct ctt gct gct atg tct gtc 528 Leu Pro Phe Ala Thr Met Gly Ser Gly Ser Leu Ala Ala Met Ser Val 165 170 175 ttt gag gca aag tat aaa gaa ggt cta act agg gat gaa gga att aag 576 Phe Glu Ala Lys Tyr Lys Glu Gly Leu Thr Arg Asp Glu Gly Ile Lys 180 185 190 ctg gtc gct gag gcc ata tgc tcg ggt ata ttc aac gac ctg ggt agt 624 Leu Val Ala Glu Ala Ile Cys Ser Gly Ile Phe Asn Asp Leu Gly Ser 195 200 205 ggt agc aac gtg gac atc tgc gta atc act aag gga aac aag gag tat 672 Gly Ser Asn Val Asp Ile Cys Val Ile Thr Lys Gly Asn Lys Glu Tyr 210 215 220 ctg agg aac tac atg gaa cca aac cca aga acc tat gtc agc agc aaa 720 Leu Arg Asn Tyr Met Glu Pro Asn Pro Arg Thr Tyr Val Ser Ser Lys 225 230 235 240 ggc tat tcg ttc acc aag aaa acc gag gtt ctt cgg acc aaa atc acc 768 Page 485 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Tyr Ser Phe Thr Lys Lys Thr Glu Val Leu Arg Thr Lys Ile Thr 245 250 255 cca ttg atg gag cga gtt gaa att aca gaa gtg act ggt gaa gct atg 816 Pro Leu Met Glu Arg Val Glu Ile Thr Glu Val Thr Gly Glu Ala Met 260 265 270 gaa gag taa 825 Glu Glu <210> 373 <211> 274 <212> PRT <213> Brassica napus <400> 373 Met Ser Gln Ser Thr Val Asp Val Pro Pro Lys Gly Gly Phe Ser Phe 1 5 10 15 Asp Leu Cys Lys Arg Asn Asp Met Leu Ile Gln Lys Gly Leu Lys Ala 20 25 30 Pro Ser Phe Leu Lys Thr Gly Thr Thr Ile Val Gly Leu Ile Phe Lys 35 40 45 Asp Gly Val Ile Leu Gly Ala Asp Thr Arg Ala Thr Glu Gly Pro Ile 50 55 60 Val Ala Asp Lys Asn Cys Glu Lys Ile His Tyr Met Ala Pro Asn Ile 65 70 75 80 Tyr Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Glu Ala Val Thr Asp 85 90 95 Met Val Ser Ser Gln Leu Arg Leu His Arg Tyr Gln Thr Gly Arg Asp 100 105 110 Ser Arg Val Ile Thr Ala Leu Thr Leu Leu Lys Lys His Leu Phe Ser 115 120 125 Tyr Gln Gly His Val Ser Ala Ala Leu Val Leu Gly Gly Val Asp Ile 130 135 140 Thr Gly Pro His Leu His Thr Ile Tyr Pro His Gly Ser Thr Asp Thr 145 150 155 160 Leu Pro Phe Ala Thr Met Gly Ser Gly Ser Leu Ala Ala Met Ser Val 165 170 175 Phe Glu Ala Lys Tyr Lys Glu Gly Leu Thr Arg Asp Glu Gly Ile Lys 180 185 190 Leu Val Ala Glu Ala Ile Cys Ser Gly Ile Phe Asn Asp Leu Gly Ser 195 200 205 Gly Ser Asn Val Asp Ile Cys Val Ile Thr Lys Gly Asn Lys Glu Tyr 210 215 220 Leu Arg Asn Tyr Met Glu Pro Asn Pro Arg Thr Tyr Val Ser Ser Lys 225 230 235 240 Gly Tyr Ser Phe Thr Lys Lys Thr Glu Val Leu Arg Thr Lys Ile Thr 245 250 255 Pro Leu Met Glu Arg Val Glu Ile Thr Glu Val Thr Gly Glu Ala Met 260 265 270 Glu Glu <210> 374 <211> 786 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(786) <400> 374 atg gct gtc ggg aag aac aag agg atc tca aaa ggt cgt aaa gga ggg 48 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Gly 1 5 10 15 aag aag aag att gtt gat cca ttc tcc aag aag gat tgg tat gac atc 96 Lys Lys Lys Ile Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 Page 486 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag gct ccc tct atc ttc aaa cag aga aat gtc ggc aag aca ctt gtt 144 Lys Ala Pro Ser Ile Phe Lys Gln Arg Asn Val Gly Lys Thr Leu Val 35 40 45 tct aga act cag ggt acc aag att gcc tct gag ggt ttg aaa cac aga 192 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 gtt ttc gag gtt tct ctt gct gat ctc caa ggt gat gag gac cac tct 240 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ser 65 70 75 80 tac agg aag atc cgt ctc aga gct gaa gat gtt cag ggc agg aat gtc 288 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 ttg acc cag ttc tgg ggt atg gat ttc acc acc gac aag ctg agg tcg 336 Leu Thr Gln Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 ttg gtg aag aag tgg cag act ttg att gaa gct cat gtc gat gtg aag 384 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 acc act gac agc tac acc ttg agg ttg ttc tgc att gct ttc acc aag 432 Thr Thr Asp Ser Tyr Thr Leu Arg Leu Phe Cys Ile Ala Phe Thr Lys 130 135 140 agg cgt gct aac cag gtc aag cgt act tgc tat gct cag tcc agc caa 480 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 atc cgc cag atc cgc agg aag atg agt gaa atc atg gtg aag gag gct 528 Ile Arg Gln Ile Arg Arg Lys Met Ser Glu Ile Met Val Lys Glu Ala 165 170 175 tca tcc tgt gac ctt aag gag ctt gtg gcc aag ttc atc cct gag tcc 576 Ser Ser Cys Asp Leu Lys Glu Leu Val Ala Lys Phe Ile Pro Glu Ser 180 185 190 att gga aga gat att gag aag gcg act cag aac atc tac ccg ttg cag 624 Ile Gly Arg Asp Ile Glu Lys Ala Thr Gln Asn Ile Tyr Pro Leu Gln 195 200 205 aat gtg ttc atc cgt aag gtc aag atc ctc aag gct ccc aag ttt gac 672 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 ctt ggc aag ctc atg gag gtt cat ggt gac tac aca gca gag gat gtt 720 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Thr Ala Glu Asp Val 225 230 235 240 ggt gtg aaa gta gac agg cca gat gaa aca gtg gct gag gaa cca acc 768 Gly Val Lys Val Asp Arg Pro Asp Glu Thr Val Ala Glu Glu Pro Thr 245 250 255 gaa atc atc gga gct tag 786 Glu Ile Ile Gly Ala 260 <210> 375 <211> 261 <212> PRT <213> Brassica napus <400> 375 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Gly 1 5 10 15 Lys Lys Lys Ile Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 Lys Ala Pro Ser Ile Phe Lys Gln Arg Asn Val Gly Lys Thr Leu Val 35 40 45 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ser 65 70 75 80 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 Leu Thr Gln Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 Page 487 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Thr Asp Ser Tyr Thr Leu Arg Leu Phe Cys Ile Ala Phe Thr Lys 130 135 140 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 Ile Arg Gln Ile Arg Arg Lys Met Ser Glu Ile Met Val Lys Glu Ala 165 170 175 Ser Ser Cys Asp Leu Lys Glu Leu Val Ala Lys Phe Ile Pro Glu Ser 180 185 190 Ile Gly Arg Asp Ile Glu Lys Ala Thr Gln Asn Ile Tyr Pro Leu Gln 195 200 205 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Thr Ala Glu Asp Val 225 230 235 240 Gly Val Lys Val Asp Arg Pro Asp Glu Thr Val Ala Glu Glu Pro Thr 245 250 255 Glu Ile Ile Gly Ala 260 <210> 376 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 376 atg gct cgc acc aag caa acc gcc agg aaa tca acc gga ggc aaa gcc 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 cca aga aag cag ctc gcg acc aaa gcg gcg agg aaa tca gct ccg gcc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acc gga gga gtg aag aag ccg cac agg ttc cgt cca gga acg gtg gcg 144 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 ctg agg gag atc agg aag tac cag aag agc acc gag ctt ctg atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctc ccc ttc cag cgt ctg gtc cgt gag atc gct cag gat ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acg gat ctg agg ttc cag agc agc gcc gtc gcc gct ttg caa gag gct 288 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gcg gag gct tac ctc gtt ggg ctg ttc gaa gac acg aat ctc tgc gcg 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gcc aag agg gtt acg atc atg ccg aag gat atc cag ctc gcg 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 agg aga atc cgt ggc gaa aga gct tga 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 377 <211> 136 <212> PRT <213> Brassica napus <400> 377 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala Page 488 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 378 <211> 1062 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1062) <400> 378 atg gga aag gag gca ttt gga ttg gcc gcg aaa gac aat tct gga gtt 48 Met Gly Lys Glu Ala Phe Gly Leu Ala Ala Lys Asp Asn Ser Gly Val 1 5 10 15 ctc tcg cct ttc cat ttc tct aga agg gag aca gga gag aag gat gtt 96 Leu Ser Pro Phe His Phe Ser Arg Arg Glu Thr Gly Glu Lys Asp Val 20 25 30 agg ttc aaa gtt ttg ttc tgt gga atc tgt cac tct gat ttg cat atg 144 Arg Phe Lys Val Leu Phe Cys Gly Ile Cys His Ser Asp Leu His Met 35 40 45 atc aag aat gag tgg gga ata tct act tac cct ctc gtc ccc ggg cat 192 Ile Lys Asn Glu Trp Gly Ile Ser Thr Tyr Pro Leu Val Pro Gly His 50 55 60 gag att gtt ggt gtg gtg act gaa gtg gga agc aaa gtg act aaa ttc 240 Glu Ile Val Gly Val Val Thr Glu Val Gly Ser Lys Val Thr Lys Phe 65 70 75 80 aaa act gga gac aaa gtc gga gta ggt tgc atg gtt ggc tcg tgc gga 288 Lys Thr Gly Asp Lys Val Gly Val Gly Cys Met Val Gly Ser Cys Gly 85 90 95 tca tgt gat agc tgc acc gaa ggt ctc gag aac tac tgt cca aaa tcg 336 Ser Cys Asp Ser Cys Thr Glu Gly Leu Glu Asn Tyr Cys Pro Lys Ser 100 105 110 atc caa acg tac gga ttc aag tat tac gac gac aca ata acc tac ggt 384 Ile Gln Thr Tyr Gly Phe Lys Tyr Tyr Asp Asp Thr Ile Thr Tyr Gly 115 120 125 ggt tac tcc gac aac atg gtt tgc gac gaa ggt ttc atc atc cgt atg 432 Gly Tyr Ser Asp Asn Met Val Cys Asp Glu Gly Phe Ile Ile Arg Met 130 135 140 ccc gaa aat ctc cca ttg gac gct gct gct ccg cta cta tgc gcg ggg 480 Pro Glu Asn Leu Pro Leu Asp Ala Ala Ala Pro Leu Leu Cys Ala Gly 145 150 155 160 atc acg gtc tac tcc ccg ctg aaa cat cac ggg ctc gac aag cct ggc 528 Ile Thr Val Tyr Ser Pro Leu Lys His His Gly Leu Asp Lys Pro Gly 165 170 175 atg cac att ggt gtg gtt gga cta ggc ggt ttg ggt cat gtg gcg gtg 576 Met His Ile Gly Val Val Gly Leu Gly Gly Leu Gly His Val Ala Val 180 185 190 aaa ttt gct aag gct atg ggt ctt aag gtt acg gtt att agt act tcg 624 Lys Phe Ala Lys Ala Met Gly Leu Lys Val Thr Val Ile Ser Thr Ser 195 200 205 gat agt aag aga gat gaa gcg att aat agg ctt ggt gcg gac gcg ttc 672 Asp Ser Lys Arg Asp Glu Ala Ile Asn Arg Leu Gly Ala Asp Ala Phe 210 215 220 gtg gtg agc cgt gac caa aaa cag att aag gat gca atg agg aca ttg 720 Val Val Ser Arg Asp Gln Lys Gln Ile Lys Asp Ala Met Arg Thr Leu Page 489 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 225 230 235 240 gat ggt att att aat acc gta tct gcg act cat tcc ctt ctt cct ttg 768 Asp Gly Ile Ile Asn Thr Val Ser Ala Thr His Ser Leu Leu Pro Leu 245 250 255 ctc ggt ttg cta aag cct aag gga aaa ctt gtt atg gtt ggt gca cca 816 Leu Gly Leu Leu Lys Pro Lys Gly Lys Leu Val Met Val Gly Ala Pro 260 265 270 gaa aag cca ctc gag ctc ccg gtc atg cct ctc atc ttc gag agg aag 864 Glu Lys Pro Leu Glu Leu Pro Val Met Pro Leu Ile Phe Glu Arg Lys 275 280 285 atg gta atg gga agt atg ata gga ggg ata aag gag act caa gag atg 912 Met Val Met Gly Ser Met Ile Gly Gly Ile Lys Glu Thr Gln Glu Met 290 295 300 gtg gat atg gca gga aaa cac aac atc act gct gat att gag ctt atc 960 Val Asp Met Ala Gly Lys His Asn Ile Thr Ala Asp Ile Glu Leu Ile 305 310 315 320 tct gcg gac tat gtc aac act gcc atg gaa cgg ctc gag aag gcc gac 1008 Ser Ala Asp Tyr Val Asn Thr Ala Met Glu Arg Leu Glu Lys Ala Asp 325 330 335 gtt aga tac cgt ttt gtg att gat gtt gcc aac aca ttg aag cct act 1056 Val Arg Tyr Arg Phe Val Ile Asp Val Ala Asn Thr Leu Lys Pro Thr 340 345 350 cct taa 1062 Pro <210> 379 <211> 353 <212> PRT <213> Brassica napus <400> 379 Met Gly Lys Glu Ala Phe Gly Leu Ala Ala Lys Asp Asn Ser Gly Val 1 5 10 15 Leu Ser Pro Phe His Phe Ser Arg Arg Glu Thr Gly Glu Lys Asp Val 20 25 30 Arg Phe Lys Val Leu Phe Cys Gly Ile Cys His Ser Asp Leu His Met 35 40 45 Ile Lys Asn Glu Trp Gly Ile Ser Thr Tyr Pro Leu Val Pro Gly His 50 55 60 Glu Ile Val Gly Val Val Thr Glu Val Gly Ser Lys Val Thr Lys Phe 65 70 75 80 Lys Thr Gly Asp Lys Val Gly Val Gly Cys Met Val Gly Ser Cys Gly 85 90 95 Ser Cys Asp Ser Cys Thr Glu Gly Leu Glu Asn Tyr Cys Pro Lys Ser 100 105 110 Ile Gln Thr Tyr Gly Phe Lys Tyr Tyr Asp Asp Thr Ile Thr Tyr Gly 115 120 125 Gly Tyr Ser Asp Asn Met Val Cys Asp Glu Gly Phe Ile Ile Arg Met 130 135 140 Pro Glu Asn Leu Pro Leu Asp Ala Ala Ala Pro Leu Leu Cys Ala Gly 145 150 155 160 Ile Thr Val Tyr Ser Pro Leu Lys His His Gly Leu Asp Lys Pro Gly 165 170 175 Met His Ile Gly Val Val Gly Leu Gly Gly Leu Gly His Val Ala Val 180 185 190 Lys Phe Ala Lys Ala Met Gly Leu Lys Val Thr Val Ile Ser Thr Ser 195 200 205 Asp Ser Lys Arg Asp Glu Ala Ile Asn Arg Leu Gly Ala Asp Ala Phe 210 215 220 Val Val Ser Arg Asp Gln Lys Gln Ile Lys Asp Ala Met Arg Thr Leu 225 230 235 240 Asp Gly Ile Ile Asn Thr Val Ser Ala Thr His Ser Leu Leu Pro Leu 245 250 255 Leu Gly Leu Leu Lys Pro Lys Gly Lys Leu Val Met Val Gly Ala Pro 260 265 270 Glu Lys Pro Leu Glu Leu Pro Val Met Pro Leu Ile Phe Glu Arg Lys 275 280 285 Page 490 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Val Met Gly Ser Met Ile Gly Gly Ile Lys Glu Thr Gln Glu Met 290 295 300 Val Asp Met Ala Gly Lys His Asn Ile Thr Ala Asp Ile Glu Leu Ile 305 310 315 320 Ser Ala Asp Tyr Val Asn Thr Ala Met Glu Arg Leu Glu Lys Ala Asp 325 330 335 Val Arg Tyr Arg Phe Val Ile Asp Val Ala Asn Thr Leu Lys Pro Thr 340 345 350 Pro <210> 380 <211> 852 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(852) <400> 380 atg gcg tcc ggt tta atc gga aga tta gtc aga acc aaa ccg gcg aga 48 Met Ala Ser Gly Leu Ile Gly Arg Leu Val Arg Thr Lys Pro Ala Arg 1 5 10 15 tta acc acg gcg gct agg tta atc ccg tcg cga tgc aca tcc tcc tca 96 Leu Thr Thr Ala Ala Arg Leu Ile Pro Ser Arg Cys Thr Ser Ser Ser 20 25 30 acg gaa tca aaa cct tcg tcc ggc ggc gtt ggc gga ggc gga ggg aga 144 Thr Glu Ser Lys Pro Ser Ser Gly Gly Val Gly Gly Gly Gly Gly Arg 35 40 45 gga tcg aac ctg aag acg ttc cag atc tac cgg tgg aat ccc gat agc 192 Gly Ser Asn Leu Lys Thr Phe Gln Ile Tyr Arg Trp Asn Pro Asp Ser 50 55 60 ccc ggg aag ccg gag ctc caa gac tac cag atc gat ctc aag gac tgc 240 Pro Gly Lys Pro Glu Leu Gln Asp Tyr Gln Ile Asp Leu Lys Asp Cys 65 70 75 80 ggc ccg atg gta cta gac gct ctg atc aag atc aaa aac gag atg gat 288 Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys Asn Glu Met Asp 85 90 95 ccg tcg ctc acc ttc cgc cgc tcc tgc cgc gaa ggg atc tgc ggc tcg 336 Pro Ser Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser 100 105 110 tgc gcg atg aac att gac ggg tgc aac ggc ctc gcg tgt ttg acg aag 384 Cys Ala Met Asn Ile Asp Gly Cys Asn Gly Leu Ala Cys Leu Thr Lys 115 120 125 atc gaa gga gac ggg gct aag gag acg acg atc act ccc ttg ccg cat 432 Ile Glu Gly Asp Gly Ala Lys Glu Thr Thr Ile Thr Pro Leu Pro His 130 135 140 atg ttt gtg atc aag gat ctg gtg gtg gac atg acg aac ttt tat aat 480 Met Phe Val Ile Lys Asp Leu Val Val Asp Met Thr Asn Phe Tyr Asn 145 150 155 160 cag tat aag agt atc gag ccg tgg ttg aag agg aag agt ccg ggg gat 528 Gln Tyr Lys Ser Ile Glu Pro Trp Leu Lys Arg Lys Ser Pro Gly Asp 165 170 175 gag gct ggg aag gag att ctg cag agt aag aag gat agg gcg aag ctt 576 Glu Ala Gly Lys Glu Ile Leu Gln Ser Lys Lys Asp Arg Ala Lys Leu 180 185 190 gat ggg atg tat gag tgt atc ttg tgt gct tgt tgt agc acg tcg tgt 624 Asp Gly Met Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys 195 200 205 cct agt tac tgg tgg aac cct gag ttt tac ctt ggc ccc gcc gct ttg 672 Pro Ser Tyr Trp Trp Asn Pro Glu Phe Tyr Leu Gly Pro Ala Ala Leu 210 215 220 cta cac gca aac agg tgg ata agc gac agt cgg gat gag tac aca aag 720 Leu His Ala Asn Arg Trp Ile Ser Asp Ser Arg Asp Glu Tyr Thr Lys 225 230 235 240 gaa aga ctc gag gct att gac gac gag ttc aag ctt tac cgt tgc cat 768 Glu Arg Leu Glu Ala Ile Asp Asp Glu Phe Lys Leu Tyr Arg Cys His Page 491 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 245 250 255 aca atc ttg aac tgt gct cgt gcc tgt cca aag ggt ttg aac cct ggc 816 Thr Ile Leu Asn Cys Ala Arg Ala Cys Pro Lys Gly Leu Asn Pro Gly 260 265 270 aaa cag atc gca cac atc aag caa ctt cag cgt tga 852 Lys Gln Ile Ala His Ile Lys Gln Leu Gln Arg 275 280 <210> 381 <211> 283 <212> PRT <213> Brassica napus <400> 381 Met Ala Ser Gly Leu Ile Gly Arg Leu Val Arg Thr Lys Pro Ala Arg 1 5 10 15 Leu Thr Thr Ala Ala Arg Leu Ile Pro Ser Arg Cys Thr Ser Ser Ser 20 25 30 Thr Glu Ser Lys Pro Ser Ser Gly Gly Val Gly Gly Gly Gly Gly Arg 35 40 45 Gly Ser Asn Leu Lys Thr Phe Gln Ile Tyr Arg Trp Asn Pro Asp Ser 50 55 60 Pro Gly Lys Pro Glu Leu Gln Asp Tyr Gln Ile Asp Leu Lys Asp Cys 65 70 75 80 Gly Pro Met Val Leu Asp Ala Leu Ile Lys Ile Lys Asn Glu Met Asp 85 90 95 Pro Ser Leu Thr Phe Arg Arg Ser Cys Arg Glu Gly Ile Cys Gly Ser 100 105 110 Cys Ala Met Asn Ile Asp Gly Cys Asn Gly Leu Ala Cys Leu Thr Lys 115 120 125 Ile Glu Gly Asp Gly Ala Lys Glu Thr Thr Ile Thr Pro Leu Pro His 130 135 140 Met Phe Val Ile Lys Asp Leu Val Val Asp Met Thr Asn Phe Tyr Asn 145 150 155 160 Gln Tyr Lys Ser Ile Glu Pro Trp Leu Lys Arg Lys Ser Pro Gly Asp 165 170 175 Glu Ala Gly Lys Glu Ile Leu Gln Ser Lys Lys Asp Arg Ala Lys Leu 180 185 190 Asp Gly Met Tyr Glu Cys Ile Leu Cys Ala Cys Cys Ser Thr Ser Cys 195 200 205 Pro Ser Tyr Trp Trp Asn Pro Glu Phe Tyr Leu Gly Pro Ala Ala Leu 210 215 220 Leu His Ala Asn Arg Trp Ile Ser Asp Ser Arg Asp Glu Tyr Thr Lys 225 230 235 240 Glu Arg Leu Glu Ala Ile Asp Asp Glu Phe Lys Leu Tyr Arg Cys His 245 250 255 Thr Ile Leu Asn Cys Ala Arg Ala Cys Pro Lys Gly Leu Asn Pro Gly 260 265 270 Lys Gln Ile Ala His Ile Lys Gln Leu Gln Arg 275 280 <210> 382 <211> 411 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(411) <400> 382 atg gct cgt acc aag caa aca gct aga aaa tcc acc gga ggc aag gcc 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 cca agg aag cag ctc gca aca aaa gcg gca aga aaa tct gct ccg gcc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acc ggc gga gtg aag aag ccg cac aga ttc cgt ccc gga aca gtc gcc 144 Page 492 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 ttg aga gag atc aga aag tac caa aaa agc aca gag ctt ctg atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctc ccc ttc cag cgt cta gtc cgt gag atc gct cag gat ttc aaa 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acc gat ctg agg ttc cag agc agc gcc gtc gca gct ctt caa gaa gca 288 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gct gaa gct tac ctt gtt ggg ttg ttc gaa gac acg aat ctc tgc gcg 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gcg aag aga gta aca atc atg cca aag gat atc cag ctg gca 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 aga aga atc aga ggc gaa aga gct tga 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 383 <211> 136 <212> PRT <213> Brassica napus <400> 383 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 384 <211> 192 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(192) <400> 384 atg atg aag cgt ctg atc cca acg ttc aac cgc atc ctg gtg cag aga 48 Met Met Lys Arg Leu Ile Pro Thr Phe Asn Arg Ile Leu Val Gln Arg 1 5 10 15 gtc atc cag cct gct aaa acc gag agc ggc atc ctc ctc cct gag aaa 96 Val Ile Gln Pro Ala Lys Thr Glu Ser Gly Ile Leu Leu Pro Glu Lys 20 25 30 gcc tcc aag ctg aac tcg ggc aag gtg ata gca gtt gga cct gga tca 144 Ala Ser Lys Leu Asn Ser Gly Lys Val Ile Ala Val Gly Pro Gly Ser 35 40 45 agg gat aag gac ggg aaa ttt gat tcc ggt ctc tgt caa gga agg 189 Arg Asp Lys Asp Gly Lys Phe Asp Ser Gly Leu Cys Gln Gly Arg 50 55 60 Page 493 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt tga 192 <210> 385 <211> 63 <212> PRT <213> Brassica napus <400> 385 Met Met Lys Arg Leu Ile Pro Thr Phe Asn Arg Ile Leu Val Gln Arg 1 5 10 15 Val Ile Gln Pro Ala Lys Thr Glu Ser Gly Ile Leu Leu Pro Glu Lys 20 25 30 Ala Ser Lys Leu Asn Ser Gly Lys Val Ile Ala Val Gly Pro Gly Ser 35 40 45 Arg Asp Lys Asp Gly Lys Phe Asp Ser Gly Leu Cys Gln Gly Arg 50 55 60 <210> 386 <211> 426 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(426) <400> 386 atg aaa ggt ggt gaa acc aaa gct caa tcg aag agc acc gat gaa aga 48 Met Lys Gly Gly Glu Thr Lys Ala Gln Ser Lys Ser Thr Asp Glu Arg 1 5 10 15 ttg aaa acg aga gga aag aaa gct gga aag aaa gca gcc aag gat cct 96 Leu Lys Thr Arg Gly Lys Lys Ala Gly Lys Lys Ala Ala Lys Asp Pro 20 25 30 aac aag cct aag agg cct cca agt gcc ttc ttc gtc ttc ctg gag gga 144 Asn Lys Pro Lys Arg Pro Pro Ser Ala Phe Phe Val Phe Leu Glu Gly 35 40 45 ttc cgt aag gag ttc aat cta gct aac cct gac aac aaa tcc gtc gga 192 Phe Arg Lys Glu Phe Asn Leu Ala Asn Pro Asp Asn Lys Ser Val Gly 50 55 60 gct gtt ggt aaa gct gct gga gct aaa tgg aaa tca atg act gat gaa 240 Ala Val Gly Lys Ala Ala Gly Ala Lys Trp Lys Ser Met Thr Asp Glu 65 70 75 80 gac aaa gct cct tat gtg gcc aag gca gag agc aag aag act gaa tat 288 Asp Lys Ala Pro Tyr Val Ala Lys Ala Glu Ser Lys Lys Thr Glu Tyr 85 90 95 acc aag act atg caa aag tac aac atg aaa ctg gct aat gga act agc 336 Thr Lys Thr Met Gln Lys Tyr Asn Met Lys Leu Ala Asn Gly Thr Ser 100 105 110 aca gct gga gat gat gac tct gac aag tcc aag tcc gaa gtc aac gat 384 Thr Ala Gly Asp Asp Asp Ser Asp Lys Ser Lys Ser Glu Val Asn Asp 115 120 125 gaa gca gaa ggt gga agt gaa gag gag gaa gat gat gat tag 426 Glu Ala Glu Gly Gly Ser Glu Glu Glu Glu Asp Asp Asp 130 135 140 <210> 387 <211> 141 <212> PRT <213> Brassica napus <400> 387 Met Lys Gly Gly Glu Thr Lys Ala Gln Ser Lys Ser Thr Asp Glu Arg 1 5 10 15 Leu Lys Thr Arg Gly Lys Lys Ala Gly Lys Lys Ala Ala Lys Asp Pro 20 25 30 Asn Lys Pro Lys Arg Pro Pro Ser Ala Phe Phe Val Phe Leu Glu Gly Page 494 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 35 40 45 Phe Arg Lys Glu Phe Asn Leu Ala Asn Pro Asp Asn Lys Ser Val Gly 50 55 60 Ala Val Gly Lys Ala Ala Gly Ala Lys Trp Lys Ser Met Thr Asp Glu 65 70 75 80 Asp Lys Ala Pro Tyr Val Ala Lys Ala Glu Ser Lys Lys Thr Glu Tyr 85 90 95 Thr Lys Thr Met Gln Lys Tyr Asn Met Lys Leu Ala Asn Gly Thr Ser 100 105 110 Thr Ala Gly Asp Asp Asp Ser Asp Lys Ser Lys Ser Glu Val Asn Asp 115 120 125 Glu Ala Glu Gly Gly Ser Glu Glu Glu Glu Asp Asp Asp 130 135 140 <210> 388 <211> 804 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(804) <400> 388 atg tac cgc cga agg gtg ggt tca gct tcg atc tgt gca aga gaa acg 48 Met Tyr Arg Arg Arg Val Gly Ser Ala Ser Ile Cys Ala Arg Glu Thr 1 5 10 15 ata tgc tta tcc aaa agg gtc tta aag ctc cct cct ttt ttg aag acc 96 Ile Cys Leu Ser Lys Arg Val Leu Lys Leu Pro Pro Phe Leu Lys Thr 20 25 30 ggt act acc atc gtc ggt ttg atc ttc aag gat ggt gtt ata cta ggc 144 Gly Thr Thr Ile Val Gly Leu Ile Phe Lys Asp Gly Val Ile Leu Gly 35 40 45 gct gat aca cga gca act gag gga cct atc gtt gct gat aag aac tgt 192 Ala Asp Thr Arg Ala Thr Glu Gly Pro Ile Val Ala Asp Lys Asn Cys 50 55 60 gag aag att cac tac atg gca cct aac att tac tgc tgt ggt gct gga 240 Glu Lys Ile His Tyr Met Ala Pro Asn Ile Tyr Cys Cys Gly Ala Gly 65 70 75 80 acc gct gct gac act gaa gct gtc act gat atg gtc agc tca cag ctg 288 Thr Ala Ala Asp Thr Glu Ala Val Thr Asp Met Val Ser Ser Gln Leu 85 90 95 agg ttg cat cgt tac cag act ggg cga gac tct cgg gtc atc act gct 336 Arg Leu His Arg Tyr Gln Thr Gly Arg Asp Ser Arg Val Ile Thr Ala 100 105 110 ttg acc ctt ctc aaa aag cac ctt ttc agc tat caa ggt cat gtc tca 384 Leu Thr Leu Leu Lys Lys His Leu Phe Ser Tyr Gln Gly His Val Ser 115 120 125 gct gct ctt gtc ctt ggt gga gtc gat atc acc ggg cct cat ctg cat 432 Ala Ala Leu Val Leu Gly Gly Val Asp Ile Thr Gly Pro His Leu His 130 135 140 acc ata tac cca cac ggt tca act gac act cta cca ttc gct aca atg 480 Thr Ile Tyr Pro His Gly Ser Thr Asp Thr Leu Pro Phe Ala Thr Met 145 150 155 160 ggt tct ggt tct ctt gct gct atg tct gtc ttt gag gca aag tac aaa 528 Gly Ser Gly Ser Leu Ala Ala Met Ser Val Phe Glu Ala Lys Tyr Lys 165 170 175 gaa ggt cta act agg gac gaa gga atc aag ctg gtg gct gaa gcc ata 576 Glu Gly Leu Thr Arg Asp Glu Gly Ile Lys Leu Val Ala Glu Ala Ile 180 185 190 tgc tcg gga ata ttc aac gac ctg ggt agt ggt agc aac gtg gac atc 624 Cys Ser Gly Ile Phe Asn Asp Leu Gly Ser Gly Ser Asn Val Asp Ile 195 200 205 tgc gtg atc aca aag ggg cac aag gaa tat ctc agg aac tac atg gaa 672 Cys Val Ile Thr Lys Gly His Lys Glu Tyr Leu Arg Asn Tyr Met Glu 210 215 220 cca aac cca aga acc tat gtc agc agc aaa ggc tat tca ttc acc aag 720 Pro Asn Pro Arg Thr Tyr Val Ser Ser Lys Gly Tyr Ser Phe Thr Lys Page 495 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 225 230 235 240 aaa acc gag gtt ctt cgc acg aaa atc acc cca ttg atg gag cga gtt 768 Lys Thr Glu Val Leu Arg Thr Lys Ile Thr Pro Leu Met Glu Arg Val 245 250 255 gag att aca gaa gtg ggt gaa gct atg gaa gaa tga 804 Glu Ile Thr Glu Val Gly Glu Ala Met Glu Glu 260 265 <210> 389 <211> 267 <212> PRT <213> Brassica napus <400> 389 Met Tyr Arg Arg Arg Val Gly Ser Ala Ser Ile Cys Ala Arg Glu Thr 1 5 10 15 Ile Cys Leu Ser Lys Arg Val Leu Lys Leu Pro Pro Phe Leu Lys Thr 20 25 30 Gly Thr Thr Ile Val Gly Leu Ile Phe Lys Asp Gly Val Ile Leu Gly 35 40 45 Ala Asp Thr Arg Ala Thr Glu Gly Pro Ile Val Ala Asp Lys Asn Cys 50 55 60 Glu Lys Ile His Tyr Met Ala Pro Asn Ile Tyr Cys Cys Gly Ala Gly 65 70 75 80 Thr Ala Ala Asp Thr Glu Ala Val Thr Asp Met Val Ser Ser Gln Leu 85 90 95 Arg Leu His Arg Tyr Gln Thr Gly Arg Asp Ser Arg Val Ile Thr Ala 100 105 110 Leu Thr Leu Leu Lys Lys His Leu Phe Ser Tyr Gln Gly His Val Ser 115 120 125 Ala Ala Leu Val Leu Gly Gly Val Asp Ile Thr Gly Pro His Leu His 130 135 140 Thr Ile Tyr Pro His Gly Ser Thr Asp Thr Leu Pro Phe Ala Thr Met 145 150 155 160 Gly Ser Gly Ser Leu Ala Ala Met Ser Val Phe Glu Ala Lys Tyr Lys 165 170 175 Glu Gly Leu Thr Arg Asp Glu Gly Ile Lys Leu Val Ala Glu Ala Ile 180 185 190 Cys Ser Gly Ile Phe Asn Asp Leu Gly Ser Gly Ser Asn Val Asp Ile 195 200 205 Cys Val Ile Thr Lys Gly His Lys Glu Tyr Leu Arg Asn Tyr Met Glu 210 215 220 Pro Asn Pro Arg Thr Tyr Val Ser Ser Lys Gly Tyr Ser Phe Thr Lys 225 230 235 240 Lys Thr Glu Val Leu Arg Thr Lys Ile Thr Pro Leu Met Glu Arg Val 245 250 255 Glu Ile Thr Glu Val Gly Glu Ala Met Glu Glu 260 265 <210> 390 <211> 1593 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1593) <400> 390 atg gac gat ccg acg acc cct tct cca tac gat ctt ctc ttt gaa ggt 48 Met Asp Asp Pro Thr Thr Pro Ser Pro Tyr Asp Leu Leu Phe Glu Gly 1 5 10 15 ctc tgg ctc atc cca att cgt cac tat ctc tac gct ctc atc ctc atc 96 Leu Trp Leu Ile Pro Ile Arg His Tyr Leu Tyr Ala Leu Ile Leu Ile 20 25 30 tgg acc gta ttc ttc tac aat ttc gtg gag ttc cat ttc ctt ggt gat 144 Trp Thr Val Phe Phe Tyr Asn Phe Val Glu Phe His Phe Leu Gly Asp 35 40 45 Page 496 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gcg gtt ctt cag tat ttc aga ggt cga gtg aat ctc atc tac aac cca 192 Ala Val Leu Gln Tyr Phe Arg Gly Arg Val Asn Leu Ile Tyr Asn Pro 50 55 60 gat tct cct att tac cac ggt gtt gtc tct cgc tgc cgg act ctt cac 240 Asp Ser Pro Ile Tyr His Gly Val Val Ser Arg Cys Arg Thr Leu His 65 70 75 80 ggc cgg tat gtg gcg aca ccg tgg tta gcg agt cct cat ctt cag act 288 Gly Arg Tyr Val Ala Thr Pro Trp Leu Ala Ser Pro His Leu Gln Thr 85 90 95 tgt ttc ctt aat ttc cat gga ttg cct ccc gtt ttc acc tac aca aga 336 Cys Phe Leu Asn Phe His Gly Leu Pro Pro Val Phe Thr Tyr Thr Arg 100 105 110 aag ctc ttt cgt gct tct gat ggt gga acc att gct ctc gat tgg ctt 384 Lys Leu Phe Arg Ala Ser Asp Gly Gly Thr Ile Ala Leu Asp Trp Leu 115 120 125 acc aac tcc cat gtt gat gat gca gat cct cac aat cag aat gaa atc 432 Thr Asn Ser His Val Asp Asp Ala Asp Pro His Asn Gln Asn Glu Ile 130 135 140 agt aaa gaa gac aca act cct att gct gtt gtt att cca ggg cta act 480 Ser Lys Glu Asp Thr Thr Pro Ile Ala Val Val Ile Pro Gly Leu Thr 145 150 155 160 agt gat tct tct tct gca tat cta aag cac ctt gcc tat aac act gca 528 Ser Asp Ser Ser Ser Ala Tyr Leu Lys His Leu Ala Tyr Asn Thr Ala 165 170 175 aaa tcc ggt tgg aat gtt gtt ata agc aac cat aga gga ctg ggt ggt 576 Lys Ser Gly Trp Asn Val Val Ile Ser Asn His Arg Gly Leu Gly Gly 180 185 190 att tct gtc act tcc gat tgc ttc tat aat gct gga tgg aca gag gat 624 Ile Ser Val Thr Ser Asp Cys Phe Tyr Asn Ala Gly Trp Thr Glu Asp 195 200 205 gta cgg gta gtt ctt gat cat ctt caa cac gag ttc cct atg gct cct 672 Val Arg Val Val Leu Asp His Leu Gln His Glu Phe Pro Met Ala Pro 210 215 220 ctc ttt gct att gga act agc att ggc gct aat att ctg gtg aaa tac 720 Leu Phe Ala Ile Gly Thr Ser Ile Gly Ala Asn Ile Leu Val Lys Tyr 225 230 235 240 ctt ggg gaa gag ggt gag aag act cct ctg agg ggc ggt gtt gct att 768 Leu Gly Glu Glu Gly Glu Lys Thr Pro Leu Arg Gly Gly Val Ala Ile 245 250 255 tgc tct cca tgg gac ctc ttg att ggt gac agg ttt atc tcc cga aaa 816 Cys Ser Pro Trp Asp Leu Leu Ile Gly Asp Arg Phe Ile Ser Arg Lys 260 265 270 ttc aaa caa agg ttg tac gac aga gct cta acc atc gga ctt caa ggt 864 Phe Lys Gln Arg Leu Tyr Asp Arg Ala Leu Thr Ile Gly Leu Gln Gly 275 280 285 tat gcc caa tta cat gaa cct cag tat aca cgg ctt gct aat tgg gaa 912 Tyr Ala Gln Leu His Glu Pro Gln Tyr Thr Arg Leu Ala Asn Trp Glu 290 295 300 ggc ata aaa aag tca cgt tcc atc cga gat ttt gac aat cat gct aca 960 Gly Ile Lys Lys Ser Arg Ser Ile Arg Asp Phe Asp Asn His Ala Thr 305 310 315 320 tgt cat gtc ggg aaa ttt gag act gtg gat acg ttt tac cga aaa tct 1008 Cys His Val Gly Lys Phe Glu Thr Val Asp Thr Phe Tyr Arg Lys Ser 325 330 335 agc agt acc caa tac gta gga aac gtg gcg gtg ccg cta ctc tgt atc 1056 Ser Ser Thr Gln Tyr Val Gly Asn Val Ala Val Pro Leu Leu Cys Ile 340 345 350 agt gct cta gat gat ccc tta tgc aca aag gaa gct atc cct tgg gaa 1104 Ser Ala Leu Asp Asp Pro Leu Cys Thr Lys Glu Ala Ile Pro Trp Glu 355 360 365 gaa tgc cgg gca aac aaa aac att gtc ttg gtg aca aca aat cac ggg 1152 Glu Cys Arg Ala Asn Lys Asn Ile Val Leu Val Thr Thr Asn His Gly 370 375 380 gga cat cta gct ttt ttc gaa gga tta act gca tct agc ttg tgg tgg 1200 Gly His Leu Ala Phe Phe Glu Gly Leu Thr Ala Ser Ser Leu Trp Trp 385 390 395 400 gtt cgg gcc acc aac gag ttt ctt ggc gcc ctt agc tgc agt cgc tat 1248 Val Arg Ala Thr Asn Glu Phe Leu Gly Ala Leu Ser Cys Ser Arg Tyr Page 497 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 405 410 415 atg cat aca cag aaa att caa gag agt gga agc tca gga tca aga aag 1296 Met His Thr Gln Lys Ile Gln Glu Ser Gly Ser Ser Gly Ser Arg Lys 420 425 430 cag gag gaa cct tca ata aac caa ggc ccg tac ctg aac att gga gaa 1344 Gln Glu Glu Pro Ser Ile Asn Gln Gly Pro Tyr Leu Asn Ile Gly Glu 435 440 445 gac ggg ttg gta gca gca gtc aac ttg gag gaa aac acc aca cgg tca 1392 Asp Gly Leu Val Ala Ala Val Asn Leu Glu Glu Asn Thr Thr Arg Ser 450 455 460 aaa gat gca aca caa gta ttg aaa cag aga gga cca aag gtt aaa gat 1440 Lys Asp Ala Thr Gln Val Leu Lys Gln Arg Gly Pro Lys Val Lys Asp 465 470 475 480 aag aga agc ttt aac gtg ttg tgc cgc cag aca aaa cgg tcc ata tgg 1488 Lys Arg Ser Phe Asn Val Leu Cys Arg Gln Thr Lys Arg Ser Ile Trp 485 490 495 ttg ctt ggt tac ata ggc atg gta aca ggt ttc cct tta gtt ggg atg 1536 Leu Leu Gly Tyr Ile Gly Met Val Thr Gly Phe Pro Leu Val Gly Met 500 505 510 ctc atg aac tac ctc ttt cgt aag aag caa cga ccc ata aca gcc tcc 1584 Leu Met Asn Tyr Leu Phe Arg Lys Lys Gln Arg Pro Ile Thr Ala Ser 515 520 525 aag tcc tga 1593 Lys Ser 530 <210> 391 <211> 530 <212> PRT <213> Brassica napus <400> 391 Met Asp Asp Pro Thr Thr Pro Ser Pro Tyr Asp Leu Leu Phe Glu Gly 1 5 10 15 Leu Trp Leu Ile Pro Ile Arg His Tyr Leu Tyr Ala Leu Ile Leu Ile 20 25 30 Trp Thr Val Phe Phe Tyr Asn Phe Val Glu Phe His Phe Leu Gly Asp 35 40 45 Ala Val Leu Gln Tyr Phe Arg Gly Arg Val Asn Leu Ile Tyr Asn Pro 50 55 60 Asp Ser Pro Ile Tyr His Gly Val Val Ser Arg Cys Arg Thr Leu His 65 70 75 80 Gly Arg Tyr Val Ala Thr Pro Trp Leu Ala Ser Pro His Leu Gln Thr 85 90 95 Cys Phe Leu Asn Phe His Gly Leu Pro Pro Val Phe Thr Tyr Thr Arg 100 105 110 Lys Leu Phe Arg Ala Ser Asp Gly Gly Thr Ile Ala Leu Asp Trp Leu 115 120 125 Thr Asn Ser His Val Asp Asp Ala Asp Pro His Asn Gln Asn Glu Ile 130 135 140 Ser Lys Glu Asp Thr Thr Pro Ile Ala Val Val Ile Pro Gly Leu Thr 145 150 155 160 Ser Asp Ser Ser Ser Ala Tyr Leu Lys His Leu Ala Tyr Asn Thr Ala 165 170 175 Lys Ser Gly Trp Asn Val Val Ile Ser Asn His Arg Gly Leu Gly Gly 180 185 190 Ile Ser Val Thr Ser Asp Cys Phe Tyr Asn Ala Gly Trp Thr Glu Asp 195 200 205 Val Arg Val Val Leu Asp His Leu Gln His Glu Phe Pro Met Ala Pro 210 215 220 Leu Phe Ala Ile Gly Thr Ser Ile Gly Ala Asn Ile Leu Val Lys Tyr 225 230 235 240 Leu Gly Glu Glu Gly Glu Lys Thr Pro Leu Arg Gly Gly Val Ala Ile 245 250 255 Cys Ser Pro Trp Asp Leu Leu Ile Gly Asp Arg Phe Ile Ser Arg Lys 260 265 270 Phe Lys Gln Arg Leu Tyr Asp Arg Ala Leu Thr Ile Gly Leu Gln Gly 275 280 285 Page 498 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Tyr Ala Gln Leu His Glu Pro Gln Tyr Thr Arg Leu Ala Asn Trp Glu 290 295 300 Gly Ile Lys Lys Ser Arg Ser Ile Arg Asp Phe Asp Asn His Ala Thr 305 310 315 320 Cys His Val Gly Lys Phe Glu Thr Val Asp Thr Phe Tyr Arg Lys Ser 325 330 335 Ser Ser Thr Gln Tyr Val Gly Asn Val Ala Val Pro Leu Leu Cys Ile 340 345 350 Ser Ala Leu Asp Asp Pro Leu Cys Thr Lys Glu Ala Ile Pro Trp Glu 355 360 365 Glu Cys Arg Ala Asn Lys Asn Ile Val Leu Val Thr Thr Asn His Gly 370 375 380 Gly His Leu Ala Phe Phe Glu Gly Leu Thr Ala Ser Ser Leu Trp Trp 385 390 395 400 Val Arg Ala Thr Asn Glu Phe Leu Gly Ala Leu Ser Cys Ser Arg Tyr 405 410 415 Met His Thr Gln Lys Ile Gln Glu Ser Gly Ser Ser Gly Ser Arg Lys 420 425 430 Gln Glu Glu Pro Ser Ile Asn Gln Gly Pro Tyr Leu Asn Ile Gly Glu 435 440 445 Asp Gly Leu Val Ala Ala Val Asn Leu Glu Glu Asn Thr Thr Arg Ser 450 455 460 Lys Asp Ala Thr Gln Val Leu Lys Gln Arg Gly Pro Lys Val Lys Asp 465 470 475 480 Lys Arg Ser Phe Asn Val Leu Cys Arg Gln Thr Lys Arg Ser Ile Trp 485 490 495 Leu Leu Gly Tyr Ile Gly Met Val Thr Gly Phe Pro Leu Val Gly Met 500 505 510 Leu Met Asn Tyr Leu Phe Arg Lys Lys Gln Arg Pro Ile Thr Ala Ser 515 520 525 Lys Ser 530 <210> 392 <211> 1635 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1635) <400> 392 atg caa tcg tca acg tac gca gct gtt aaa gga aac gct gcg ttt gcg 48 Met Gln Ser Ser Thr Tyr Ala Ala Val Lys Gly Asn Ala Ala Phe Ala 1 5 10 15 ttt cag aga cgt agc ttc tct aac ctc gtc agc aga tcg gcg act act 96 Phe Gln Arg Arg Ser Phe Ser Asn Leu Val Ser Arg Ser Ala Thr Thr 20 25 30 acc gga att cgc ttc tcc acc ggc tct tac ttc gca caa ctc cac tct 144 Thr Gly Ile Arg Phe Ser Thr Gly Ser Tyr Phe Ala Gln Leu His Ser 35 40 45 tcc gcc tcg aaa gcc atg gga gcg aag ctt gct cgc gct gag aac ggg 192 Ser Ala Ser Lys Ala Met Gly Ala Lys Leu Ala Arg Ala Glu Asn Gly 50 55 60 att cac agt ctc tcc tcg gtc aaa gct cga tcg gtt aga gca caa gcc 240 Ile His Ser Leu Ser Ser Val Lys Ala Arg Ser Val Arg Ala Gln Ala 65 70 75 80 tcc tct ggt ggt ggt gac gaa gaa gaa gca ata cct ctg aga tct gaa 288 Ser Ser Gly Gly Gly Asp Glu Glu Glu Ala Ile Pro Leu Arg Ser Glu 85 90 95 gga aaa atc tca ggg acg gtt tta ccc ttc gtt ggt gtt gct tgt ctt 336 Gly Lys Ile Ser Gly Thr Val Leu Pro Phe Val Gly Val Ala Cys Leu 100 105 110 ggt gct atc ttg ttt ggt tat cat ctc ggg gtt gtt aac ggt gct ctt 384 Gly Ala Ile Leu Phe Gly Tyr His Leu Gly Val Val Asn Gly Ala Leu 115 120 125 gag tac ctt gct aag gat ctt ggt atc gct gat aat gct gtt ttg caa 432 Page 499 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Tyr Leu Ala Lys Asp Leu Gly Ile Ala Asp Asn Ala Val Leu Gln 130 135 140 ggg tgg att gtt agc gcg ttg ctt gct ggt gca acg gtc ggt tct ttc 480 Gly Trp Ile Val Ser Ala Leu Leu Ala Gly Ala Thr Val Gly Ser Phe 145 150 155 160 acc gga ggt gca tta gct gac aaa ttt gga aga act aga act ttt caa 528 Thr Gly Gly Ala Leu Ala Asp Lys Phe Gly Arg Thr Arg Thr Phe Gln 165 170 175 ttg gat gct atc ccg ctt gct att gga gct ttc tta tgt gca aca gct 576 Leu Asp Ala Ile Pro Leu Ala Ile Gly Ala Phe Leu Cys Ala Thr Ala 180 185 190 cag agt gtg cag act atg att gtg gga cgt ctg ctc gca ggg gtt gga 624 Gln Ser Val Gln Thr Met Ile Val Gly Arg Leu Leu Ala Gly Val Gly 195 200 205 atc gga atc tca tca gcc att gta cca ctt tac atc tcc gag ata tca 672 Ile Gly Ile Ser Ser Ala Ile Val Pro Leu Tyr Ile Ser Glu Ile Ser 210 215 220 cca act gaa att cgc ggt gca ctc gga tct gtg aac cag ttg ttc ata 720 Pro Thr Glu Ile Arg Gly Ala Leu Gly Ser Val Asn Gln Leu Phe Ile 225 230 235 240 tgt att gga ata ctc gca gcc ttg ata gct gga tta ccc ctt gca gca 768 Cys Ile Gly Ile Leu Ala Ala Leu Ile Ala Gly Leu Pro Leu Ala Ala 245 250 255 aac cct cta tgg tgg agg acg atg ttt ggt gtt gca gtt atc cct tcc 816 Asn Pro Leu Trp Trp Arg Thr Met Phe Gly Val Ala Val Ile Pro Ser 260 265 270 gtt cta tta gcc ata gga atg ggg ttt tct cca gaa agc cca agg tgg 864 Val Leu Leu Ala Ile Gly Met Gly Phe Ser Pro Glu Ser Pro Arg Trp 275 280 285 ctc gtt cag caa gga aaa ctt act caa gcg gaa aag gct atc aaa act 912 Leu Val Gln Gln Gly Lys Leu Thr Gln Ala Glu Lys Ala Ile Lys Thr 290 295 300 ctg tat ggt aaa gaa aaa gtg gtt gaa cta gtg cgt gac tta tca aac 960 Leu Tyr Gly Lys Glu Lys Val Val Glu Leu Val Arg Asp Leu Ser Asn 305 310 315 320 tct ggc caa ggt act tct gag cca gag gca gga tgg ttt gat cta ttc 1008 Ser Gly Gln Gly Thr Ser Glu Pro Glu Ala Gly Trp Phe Asp Leu Phe 325 330 335 agc agc cgc tac tgg aaa gtt gta agc gtt ggt gcg gcg ctc ttc ttg 1056 Ser Ser Arg Tyr Trp Lys Val Val Ser Val Gly Ala Ala Leu Phe Leu 340 345 350 ttt cag cag tta gct ggg ata aat gca gtt gtg tac tac tct aca tct 1104 Phe Gln Gln Leu Ala Gly Ile Asn Ala Val Val Tyr Tyr Ser Thr Ser 355 360 365 gtg ttc cgc agc gcc gga atc caa tct gat gtt gca gcc agt gct ctt 1152 Val Phe Arg Ser Ala Gly Ile Gln Ser Asp Val Ala Ala Ser Ala Leu 370 375 380 gtt gga gca tca aac gtg ttt gga act gct gtt gct tcg tct ttg atg 1200 Val Gly Ala Ser Asn Val Phe Gly Thr Ala Val Ala Ser Ser Leu Met 385 390 395 400 gac aaa atg gga agg aaa agt ctt cta ctt act agc ttt ggt gga atg 1248 Asp Lys Met Gly Arg Lys Ser Leu Leu Leu Thr Ser Phe Gly Gly Met 405 410 415 gcg ttg tct atg ctg ttg ctc tcg ttg tcc ttc aca tgg aag gct ctt 1296 Ala Leu Ser Met Leu Leu Leu Ser Leu Ser Phe Thr Trp Lys Ala Leu 420 425 430 gct gca tat tct ggc act ctt gct gtt gtt gga act gtt cta tat gtc 1344 Ala Ala Tyr Ser Gly Thr Leu Ala Val Val Gly Thr Val Leu Tyr Val 435 440 445 ctg tca ttt tcg ctt ggt gct ggc cca gta ccg gct ctt ttg ctt cca 1392 Leu Ser Phe Ser Leu Gly Ala Gly Pro Val Pro Ala Leu Leu Leu Pro 450 455 460 gag ata ttc gca tcc agg atc aga gca aaa gcc gtc gct ctt tct ctc 1440 Glu Ile Phe Ala Ser Arg Ile Arg Ala Lys Ala Val Ala Leu Ser Leu 465 470 475 480 ggc atg cac tgg atc tca aac ttt gtg att gga ctc tac ttc ttg agc 1488 Gly Met His Trp Ile Ser Asn Phe Val Ile Gly Leu Tyr Phe Leu Ser 485 490 495 Page 500 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gtt gtg act aaa ttc gga atc agc agt gtc tac ttg gga ttc gca gga 1536 Val Val Thr Lys Phe Gly Ile Ser Ser Val Tyr Leu Gly Phe Ala Gly 500 505 510 gtg tgt gtc ctt gca gtc atg tac att gca gga aac gtg gtg gag act 1584 Val Cys Val Leu Ala Val Met Tyr Ile Ala Gly Asn Val Val Glu Thr 515 520 525 aaa gga cgg tca ctc gag gaa ata gag ctt gct ctt aca tcc gga gct 1632 Lys Gly Arg Ser Leu Glu Glu Ile Glu Leu Ala Leu Thr Ser Gly Ala 530 535 540 taa 1635 <210> 393 <211> 544 <212> PRT <213> Brassica napus <400> 393 Met Gln Ser Ser Thr Tyr Ala Ala Val Lys Gly Asn Ala Ala Phe Ala 1 5 10 15 Phe Gln Arg Arg Ser Phe Ser Asn Leu Val Ser Arg Ser Ala Thr Thr 20 25 30 Thr Gly Ile Arg Phe Ser Thr Gly Ser Tyr Phe Ala Gln Leu His Ser 35 40 45 Ser Ala Ser Lys Ala Met Gly Ala Lys Leu Ala Arg Ala Glu Asn Gly 50 55 60 Ile His Ser Leu Ser Ser Val Lys Ala Arg Ser Val Arg Ala Gln Ala 65 70 75 80 Ser Ser Gly Gly Gly Asp Glu Glu Glu Ala Ile Pro Leu Arg Ser Glu 85 90 95 Gly Lys Ile Ser Gly Thr Val Leu Pro Phe Val Gly Val Ala Cys Leu 100 105 110 Gly Ala Ile Leu Phe Gly Tyr His Leu Gly Val Val Asn Gly Ala Leu 115 120 125 Glu Tyr Leu Ala Lys Asp Leu Gly Ile Ala Asp Asn Ala Val Leu Gln 130 135 140 Gly Trp Ile Val Ser Ala Leu Leu Ala Gly Ala Thr Val Gly Ser Phe 145 150 155 160 Thr Gly Gly Ala Leu Ala Asp Lys Phe Gly Arg Thr Arg Thr Phe Gln 165 170 175 Leu Asp Ala Ile Pro Leu Ala Ile Gly Ala Phe Leu Cys Ala Thr Ala 180 185 190 Gln Ser Val Gln Thr Met Ile Val Gly Arg Leu Leu Ala Gly Val Gly 195 200 205 Ile Gly Ile Ser Ser Ala Ile Val Pro Leu Tyr Ile Ser Glu Ile Ser 210 215 220 Pro Thr Glu Ile Arg Gly Ala Leu Gly Ser Val Asn Gln Leu Phe Ile 225 230 235 240 Cys Ile Gly Ile Leu Ala Ala Leu Ile Ala Gly Leu Pro Leu Ala Ala 245 250 255 Asn Pro Leu Trp Trp Arg Thr Met Phe Gly Val Ala Val Ile Pro Ser 260 265 270 Val Leu Leu Ala Ile Gly Met Gly Phe Ser Pro Glu Ser Pro Arg Trp 275 280 285 Leu Val Gln Gln Gly Lys Leu Thr Gln Ala Glu Lys Ala Ile Lys Thr 290 295 300 Leu Tyr Gly Lys Glu Lys Val Val Glu Leu Val Arg Asp Leu Ser Asn 305 310 315 320 Ser Gly Gln Gly Thr Ser Glu Pro Glu Ala Gly Trp Phe Asp Leu Phe 325 330 335 Ser Ser Arg Tyr Trp Lys Val Val Ser Val Gly Ala Ala Leu Phe Leu 340 345 350 Phe Gln Gln Leu Ala Gly Ile Asn Ala Val Val Tyr Tyr Ser Thr Ser 355 360 365 Val Phe Arg Ser Ala Gly Ile Gln Ser Asp Val Ala Ala Ser Ala Leu 370 375 380 Val Gly Ala Ser Asn Val Phe Gly Thr Ala Val Ala Ser Ser Leu Met Page 501 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 385 390 395 400 Asp Lys Met Gly Arg Lys Ser Leu Leu Leu Thr Ser Phe Gly Gly Met 405 410 415 Ala Leu Ser Met Leu Leu Leu Ser Leu Ser Phe Thr Trp Lys Ala Leu 420 425 430 Ala Ala Tyr Ser Gly Thr Leu Ala Val Val Gly Thr Val Leu Tyr Val 435 440 445 Leu Ser Phe Ser Leu Gly Ala Gly Pro Val Pro Ala Leu Leu Leu Pro 450 455 460 Glu Ile Phe Ala Ser Arg Ile Arg Ala Lys Ala Val Ala Leu Ser Leu 465 470 475 480 Gly Met His Trp Ile Ser Asn Phe Val Ile Gly Leu Tyr Phe Leu Ser 485 490 495 Val Val Thr Lys Phe Gly Ile Ser Ser Val Tyr Leu Gly Phe Ala Gly 500 505 510 Val Cys Val Leu Ala Val Met Tyr Ile Ala Gly Asn Val Val Glu Thr 515 520 525 Lys Gly Arg Ser Leu Glu Glu Ile Glu Leu Ala Leu Thr Ser Gly Ala 530 535 540 <210> 394 <211> 1302 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1302) <400> 394 atg gag atc gct act gtc gtc aag gca aat ggc ggt tgc gaa gcg gat 48 Met Glu Ile Ala Thr Val Val Lys Ala Asn Gly Gly Cys Glu Ala Asp 1 5 10 15 cga cgg cgg cgg ctc cgc cgg ttg aga tgc tcc gtg aag gat tac gct 96 Arg Arg Arg Arg Leu Arg Arg Leu Arg Cys Ser Val Lys Asp Tyr Ala 20 25 30 tgg ggc aaa atc ggg tcg gat tca ctc gtg tac aga gtc tac gcg gcg 144 Trp Gly Lys Ile Gly Ser Asp Ser Leu Val Tyr Arg Val Tyr Ala Ala 35 40 45 aat tcg gat caa cca atc gat tcg acg cga ccg tac gcg gag ctt tgg 192 Asn Ser Asp Gln Pro Ile Asp Ser Thr Arg Pro Tyr Ala Glu Leu Trp 50 55 60 atg ggg act cac gag tca ggt ccg agt tac ttg gag gat gat gat gct 240 Met Gly Thr His Glu Ser Gly Pro Ser Tyr Leu Glu Asp Asp Asp Ala 65 70 75 80 gat ggt ggc gtg acg ctt aga tcg tgg att gct gaa aac cct gag gct 288 Asp Gly Gly Val Thr Leu Arg Ser Trp Ile Ala Glu Asn Pro Glu Ala 85 90 95 ctt gga gat agg gtt ttg gag aaa tgg ggt tgt gat ctc ccc ttt ctc 336 Leu Gly Asp Arg Val Leu Glu Lys Trp Gly Cys Asp Leu Pro Phe Leu 100 105 110 ttc aag gtg ttg tcg gtg gga agg gcc ttg tcg att cag tca cat ccg 384 Phe Lys Val Leu Ser Val Gly Arg Ala Leu Ser Ile Gln Ser His Pro 115 120 125 gat aag gtt ttg gcg aag aaa ttg cat aaa gct cat cct aat cta tat 432 Asp Lys Val Leu Ala Lys Lys Leu His Lys Ala His Pro Asn Leu Tyr 130 135 140 aaa gat gat aat cac aag cct gag atg gca ttg gct tat act cag ttc 480 Lys Asp Asp Asn His Lys Pro Glu Met Ala Leu Ala Tyr Thr Gln Phe 145 150 155 160 gag gct ctt tgt ggg ttt ata cct cta cag gaa ctt aag agt gtg att 528 Glu Ala Leu Cys Gly Phe Ile Pro Leu Gln Glu Leu Lys Ser Val Ile 165 170 175 cgt gct att ccg gag ata gaa gag ctt gtt ggg agt gaa gag gca aac 576 Arg Ala Ile Pro Glu Ile Glu Glu Leu Val Gly Ser Glu Glu Ala Asn 180 185 190 caa gtc ttc tgc atc agt gaa cat gat gag gag aaa gtc aaa tct gct 624 Gln Val Phe Cys Ile Ser Glu His Asp Glu Glu Lys Val Lys Ser Ala Page 502 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 195 200 205 gtc cga act atc ttc acc ctg cta atg tct gca ggt ccc gac aca aca 672 Val Arg Thr Ile Phe Thr Leu Leu Met Ser Ala Gly Pro Asp Thr Thr 210 215 220 aag caa atc gta tcc aaa ctg aaa cac cgc ctg cat atg gag agt cag 720 Lys Gln Ile Val Ser Lys Leu Lys His Arg Leu His Met Glu Ser Gln 225 230 235 240 gaa cgc cat ctg aca gac aag gaa cgg cta gtt ttg aag ctt gag aag 768 Glu Arg His Leu Thr Asp Lys Glu Arg Leu Val Leu Lys Leu Glu Lys 245 250 255 cag tat cca gat gac att ggg gtc atc tct gca ttc ttc ttc aac tac 816 Gln Tyr Pro Asp Asp Ile Gly Val Ile Ser Ala Phe Phe Phe Asn Tyr 260 265 270 gtg aag ctc aat cct ggt gaa gcc ttg tac ctt ggt gca aac gag cca 864 Val Lys Leu Asn Pro Gly Glu Ala Leu Tyr Leu Gly Ala Asn Glu Pro 275 280 285 cat gct tac tta ttc ggt gag tgc att gag gtc atg gcc act tca gac 912 His Ala Tyr Leu Phe Gly Glu Cys Ile Glu Val Met Ala Thr Ser Asp 290 295 300 aac gta gta cga gct ggc ctc act tcc aag cct ctg gat att caa aca 960 Asn Val Val Arg Ala Gly Leu Thr Ser Lys Pro Leu Asp Ile Gln Thr 305 310 315 320 ctt tgt tcc atg ctc tca tac aaa ctg ggc ttt cct gag atc cta aag 1008 Leu Cys Ser Met Leu Ser Tyr Lys Leu Gly Phe Pro Glu Ile Leu Lys 325 330 335 gga tca agg att cga cca tac atc aca aga tac ctc ccg cct ttc gag 1056 Gly Ser Arg Ile Arg Pro Tyr Ile Thr Arg Tyr Leu Pro Pro Phe Glu 340 345 350 gag ttt gag gtt gat ctc tgt gat ctt ccc tgt gga gcc tcg acc gtg 1104 Glu Phe Glu Val Asp Leu Cys Asp Leu Pro Cys Gly Ala Ser Thr Val 355 360 365 ttt ccc tct gtt cca ggc cct tct ctt ctg ctt gtg ctc caa ggc gaa 1152 Phe Pro Ser Val Pro Gly Pro Ser Leu Leu Leu Val Leu Gln Gly Glu 370 375 380 gga ata atg tct acg gat gct tca gca gat gag gtt tcc gtg gga gat 1200 Gly Ile Met Ser Thr Asp Ala Ser Ala Asp Glu Val Ser Val Gly Asp 385 390 395 400 gtt ctg ttt gtg cct gca gat act gag att caa tta aag tct tca gct 1248 Val Leu Phe Val Pro Ala Asp Thr Glu Ile Gln Leu Lys Ser Ser Ala 405 410 415 gac ttg aag ctg tac aga gca gga att aac agt agg ttt ttg gat tct 1296 Asp Leu Lys Leu Tyr Arg Ala Gly Ile Asn Ser Arg Phe Leu Asp Ser 420 425 430 cca tag 1302 Pro <210> 395 <211> 433 <212> PRT <213> Brassica napus <400> 395 Met Glu Ile Ala Thr Val Val Lys Ala Asn Gly Gly Cys Glu Ala Asp 1 5 10 15 Arg Arg Arg Arg Leu Arg Arg Leu Arg Cys Ser Val Lys Asp Tyr Ala 20 25 30 Trp Gly Lys Ile Gly Ser Asp Ser Leu Val Tyr Arg Val Tyr Ala Ala 35 40 45 Asn Ser Asp Gln Pro Ile Asp Ser Thr Arg Pro Tyr Ala Glu Leu Trp 50 55 60 Met Gly Thr His Glu Ser Gly Pro Ser Tyr Leu Glu Asp Asp Asp Ala 65 70 75 80 Asp Gly Gly Val Thr Leu Arg Ser Trp Ile Ala Glu Asn Pro Glu Ala 85 90 95 Leu Gly Asp Arg Val Leu Glu Lys Trp Gly Cys Asp Leu Pro Phe Leu 100 105 110 Phe Lys Val Leu Ser Val Gly Arg Ala Leu Ser Ile Gln Ser His Pro Page 503 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 115 120 125 Asp Lys Val Leu Ala Lys Lys Leu His Lys Ala His Pro Asn Leu Tyr 130 135 140 Lys Asp Asp Asn His Lys Pro Glu Met Ala Leu Ala Tyr Thr Gln Phe 145 150 155 160 Glu Ala Leu Cys Gly Phe Ile Pro Leu Gln Glu Leu Lys Ser Val Ile 165 170 175 Arg Ala Ile Pro Glu Ile Glu Glu Leu Val Gly Ser Glu Glu Ala Asn 180 185 190 Gln Val Phe Cys Ile Ser Glu His Asp Glu Glu Lys Val Lys Ser Ala 195 200 205 Val Arg Thr Ile Phe Thr Leu Leu Met Ser Ala Gly Pro Asp Thr Thr 210 215 220 Lys Gln Ile Val Ser Lys Leu Lys His Arg Leu His Met Glu Ser Gln 225 230 235 240 Glu Arg His Leu Thr Asp Lys Glu Arg Leu Val Leu Lys Leu Glu Lys 245 250 255 Gln Tyr Pro Asp Asp Ile Gly Val Ile Ser Ala Phe Phe Phe Asn Tyr 260 265 270 Val Lys Leu Asn Pro Gly Glu Ala Leu Tyr Leu Gly Ala Asn Glu Pro 275 280 285 His Ala Tyr Leu Phe Gly Glu Cys Ile Glu Val Met Ala Thr Ser Asp 290 295 300 Asn Val Val Arg Ala Gly Leu Thr Ser Lys Pro Leu Asp Ile Gln Thr 305 310 315 320 Leu Cys Ser Met Leu Ser Tyr Lys Leu Gly Phe Pro Glu Ile Leu Lys 325 330 335 Gly Ser Arg Ile Arg Pro Tyr Ile Thr Arg Tyr Leu Pro Pro Phe Glu 340 345 350 Glu Phe Glu Val Asp Leu Cys Asp Leu Pro Cys Gly Ala Ser Thr Val 355 360 365 Phe Pro Ser Val Pro Gly Pro Ser Leu Leu Leu Val Leu Gln Gly Glu 370 375 380 Gly Ile Met Ser Thr Asp Ala Ser Ala Asp Glu Val Ser Val Gly Asp 385 390 395 400 Val Leu Phe Val Pro Ala Asp Thr Glu Ile Gln Leu Lys Ser Ser Ala 405 410 415 Asp Leu Lys Leu Tyr Arg Ala Gly Ile Asn Ser Arg Phe Leu Asp Ser 420 425 430 Pro <210> 396 <211> 702 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(702) <400> 396 atg gat ctc aat ctc gat gcg ccg cac tct atg ggg acg acc atc atc 48 Met Asp Leu Asn Leu Asp Ala Pro His Ser Met Gly Thr Thr Ile Ile 1 5 10 15 ggc gtc act tac aac gga ggc gtc gtc ctc gga gcc gac tca cgt acc 96 Gly Val Thr Tyr Asn Gly Gly Val Val Leu Gly Ala Asp Ser Arg Thr 20 25 30 agt aca ggc atg tac gta gcg aat cga gct tca gac aag atc act caa 144 Ser Thr Gly Met Tyr Val Ala Asn Arg Ala Ser Asp Lys Ile Thr Gln 35 40 45 ctc act gac aat gtc tac gtc tgc cgt tct gga tcg gct gct gat tct 192 Leu Thr Asp Asn Val Tyr Val Cys Arg Ser Gly Ser Ala Ala Asp Ser 50 55 60 cag gtt gtt tct gac tac gtc cgt tac ttc ctt cac cag cat aca att 240 Gln Val Val Ser Asp Tyr Val Arg Tyr Phe Leu His Gln His Thr Ile 65 70 75 80 cag ctg gga cag cct gcg act gta aag gtt tct gcc aac ctc att agg 288 Page 504 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Leu Gly Gln Pro Ala Thr Val Lys Val Ser Ala Asn Leu Ile Arg 85 90 95 atg ctc gct tac aat aac aag aac atg ctg caa act ggc ctc att gtt 336 Met Leu Ala Tyr Asn Asn Lys Asn Met Leu Gln Thr Gly Leu Ile Val 100 105 110 ggt ggc tgg gat aag tat gaa ggc ggg aag atc tac ggg att cca ctt 384 Gly Gly Trp Asp Lys Tyr Glu Gly Gly Lys Ile Tyr Gly Ile Pro Leu 115 120 125 ggt gga act gtt gtg gag cag ccg ttt gct att gga ggc tct ggc tcg 432 Gly Gly Thr Val Val Glu Gln Pro Phe Ala Ile Gly Gly Ser Gly Ser 130 135 140 agt tac cta tac ggg ttc ttt gat cag gcc tgg aaa gaa aac atg acc 480 Ser Tyr Leu Tyr Gly Phe Phe Asp Gln Ala Trp Lys Glu Asn Met Thr 145 150 155 160 aaa gaa gaa gct gag caa ctt gtt gtg aag gcg gtt tca cta gcc atc 528 Lys Glu Glu Ala Glu Gln Leu Val Val Lys Ala Val Ser Leu Ala Ile 165 170 175 gcc cgt gat gga gcc agt gga gga gtc gta cga act gtc att ata aac 576 Ala Arg Asp Gly Ala Ser Gly Gly Val Val Arg Thr Val Ile Ile Asn 180 185 190 tct gag gga gtg acc aga aac ttc tac cct ggg gat aag ttg cag ctt 624 Ser Glu Gly Val Thr Arg Asn Phe Tyr Pro Gly Asp Lys Leu Gln Leu 195 200 205 tgg cat gag gag ttg gag cct cag aac tcc ttg tta gac atc ctc aac 672 Trp His Glu Glu Leu Glu Pro Gln Asn Ser Leu Leu Asp Ile Leu Asn 210 215 220 gct gct ggt cct gaa cca atg gcc atg tga 702 Ala Ala Gly Pro Glu Pro Met Ala Met 225 230 <210> 397 <211> 233 <212> PRT <213> Brassica napus <400> 397 Met Asp Leu Asn Leu Asp Ala Pro His Ser Met Gly Thr Thr Ile Ile 1 5 10 15 Gly Val Thr Tyr Asn Gly Gly Val Val Leu Gly Ala Asp Ser Arg Thr 20 25 30 Ser Thr Gly Met Tyr Val Ala Asn Arg Ala Ser Asp Lys Ile Thr Gln 35 40 45 Leu Thr Asp Asn Val Tyr Val Cys Arg Ser Gly Ser Ala Ala Asp Ser 50 55 60 Gln Val Val Ser Asp Tyr Val Arg Tyr Phe Leu His Gln His Thr Ile 65 70 75 80 Gln Leu Gly Gln Pro Ala Thr Val Lys Val Ser Ala Asn Leu Ile Arg 85 90 95 Met Leu Ala Tyr Asn Asn Lys Asn Met Leu Gln Thr Gly Leu Ile Val 100 105 110 Gly Gly Trp Asp Lys Tyr Glu Gly Gly Lys Ile Tyr Gly Ile Pro Leu 115 120 125 Gly Gly Thr Val Val Glu Gln Pro Phe Ala Ile Gly Gly Ser Gly Ser 130 135 140 Ser Tyr Leu Tyr Gly Phe Phe Asp Gln Ala Trp Lys Glu Asn Met Thr 145 150 155 160 Lys Glu Glu Ala Glu Gln Leu Val Val Lys Ala Val Ser Leu Ala Ile 165 170 175 Ala Arg Asp Gly Ala Ser Gly Gly Val Val Arg Thr Val Ile Ile Asn 180 185 190 Ser Glu Gly Val Thr Arg Asn Phe Tyr Pro Gly Asp Lys Leu Gln Leu 195 200 205 Trp His Glu Glu Leu Glu Pro Gln Asn Ser Leu Leu Asp Ile Leu Asn 210 215 220 Ala Ala Gly Pro Glu Pro Met Ala Met 225 230 <210> 398 Page 505 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 1437 <212> DNA <213> Brassica napus <220> <221> CDS <222> (1)..(1437) <400> 398 atg gcg aat acg acc tcc ctc gtc tcc gat ttc ctc tcc ttt ctc aac 48 Met Ala Asn Thr Thr Ser Leu Val Ser Asp Phe Leu Ser Phe Leu Asn 1 5 10 15 gct tct ccc acc gct ttt cac gcc gtc gat gag tca aag agg cgg cta 96 Ala Ser Pro Thr Ala Phe His Ala Val Asp Glu Ser Lys Arg Arg Leu 20 25 30 cga cac gct ggc tat gaa cag att tcc gag aga gat gac tgg aaa ctc 144 Arg His Ala Gly Tyr Glu Gln Ile Ser Glu Arg Asp Asp Trp Lys Leu 35 40 45 gaa gcc ggc aaa aag tat ttc ttc aca agg aac tac tcc acc atc gtc 192 Glu Ala Gly Lys Lys Tyr Phe Phe Thr Arg Asn Tyr Ser Thr Ile Val 50 55 60 gct ttt gct gtt ggc aaa aaa tac gaa gct gga aac gga ttc cat ata 240 Ala Phe Ala Val Gly Lys Lys Tyr Glu Ala Gly Asn Gly Phe His Ile 65 70 75 80 ata ggt gct cac act gat agc cct tgc ctc aaa ctc aag cct gtt tct 288 Ile Gly Ala His Thr Asp Ser Pro Cys Leu Lys Leu Lys Pro Val Ser 85 90 95 aag gta acc aaa ggt gga tgc ttg gag gtt ggt gtt cag act tat gga 336 Lys Val Thr Lys Gly Gly Cys Leu Glu Val Gly Val Gln Thr Tyr Gly 100 105 110 ggt ggc ctt tgg tac act tgg ttt gat cgt gac ttg act gtt gct gga 384 Gly Gly Leu Trp Tyr Thr Trp Phe Asp Arg Asp Leu Thr Val Ala Gly 115 120 125 cgt gtt att gtc aaa gaa gac aag gcg ggt tct gtc tct tat tct cat 432 Arg Val Ile Val Lys Glu Asp Lys Ala Gly Ser Val Ser Tyr Ser His 130 135 140 cgt ctt gtc agg att gag gat cct atc atg agg att cct acc ttg gcc 480 Arg Leu Val Arg Ile Glu Asp Pro Ile Met Arg Ile Pro Thr Leu Ala 145 150 155 160 att cac ttg gac agg aat gtg aac agt gaa ggt ttt aag cca aac act 528 Ile His Leu Asp Arg Asn Val Asn Ser Glu Gly Phe Lys Pro Asn Thr 165 170 175 cag acg cac ctt gtt cca ata ctc gca acg gct atc aag gcg gag ctc 576 Gln Thr His Leu Val Pro Ile Leu Ala Thr Ala Ile Lys Ala Glu Leu 180 185 190 aat aaa gtg cca gca gaa ggt ggt gaa gag gac gga gaa aaa aag tgt 624 Asn Lys Val Pro Ala Glu Gly Gly Glu Glu Asp Gly Glu Lys Lys Cys 195 200 205 act gaa agt agt tca aaa tca aag cat cac cca ctt cta atg gag atc 672 Thr Glu Ser Ser Ser Lys Ser Lys His His Pro Leu Leu Met Glu Ile 210 215 220 att gca aat gca ctg ggt tgt aat cct gat gag ata tgc gaa ttt gag 720 Ile Ala Asn Ala Leu Gly Cys Asn Pro Asp Glu Ile Cys Glu Phe Glu 225 230 235 240 ctg caa gta tgt gac act cag cca agc att cta ggt ggt gca gca aaa 768 Leu Gln Val Cys Asp Thr Gln Pro Ser Ile Leu Gly Gly Ala Ala Lys 245 250 255 gaa ttt att ttc tca gga agg ctg gac aat ctt tgc atg tca ttt tgc 816 Glu Phe Ile Phe Ser Gly Arg Leu Asp Asn Leu Cys Met Ser Phe Cys 260 265 270 tct cta aag gca ctt ata gat gca acg tcc tct gga agt gac cta gag 864 Ser Leu Lys Ala Leu Ile Asp Ala Thr Ser Ser Gly Ser Asp Leu Glu 275 280 285 gaa gaa agt gga gta aga atg gtg gca tta ttt gat cac gaa gaa gtt 912 Glu Glu Ser Gly Val Arg Met Val Ala Leu Phe Asp His Glu Glu Val 290 295 300 ggt tcc aac tca gcg caa gga gct gga tcc cct gtc atg att gat gct 960 Gly Ser Asn Ser Ala Gln Gly Ala Gly Ser Pro Val Met Ile Asp Ala Page 506 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 305 310 315 320 atg tca cac atc aca agt tgc ttc agc tct gac gct aag gtg ctc aag 1008 Met Ser His Ile Thr Ser Cys Phe Ser Ser Asp Ala Lys Val Leu Lys 325 330 335 aaa gcg att caa aaa agc ttg ctt gtt tcc gct gac atg gct cat gct 1056 Lys Ala Ile Gln Lys Ser Leu Leu Val Ser Ala Asp Met Ala His Ala 340 345 350 tta cat cca aac ttt atg gac aaa cac gaa gag aat cat caa cca aag 1104 Leu His Pro Asn Phe Met Asp Lys His Glu Glu Asn His Gln Pro Lys 355 360 365 atg cat gga ggg ctt gtc atc aag cac aat gca aat caa cgt tac gca 1152 Met His Gly Gly Leu Val Ile Lys His Asn Ala Asn Gln Arg Tyr Ala 370 375 380 acc aat gca gta act tcg ttt gtg ttc aga gag ata gca gag aaa cat 1200 Thr Asn Ala Val Thr Ser Phe Val Phe Arg Glu Ile Ala Glu Lys His 385 390 395 400 aat ctc cct gtc cag gat ttt gtg gta cgt aat gat atg ggt tgc gga 1248 Asn Leu Pro Val Gln Asp Phe Val Val Arg Asn Asp Met Gly Cys Gly 405 410 415 tca acc att ggt cca atc cta gca agc agt gtg ggg ata agg acg gtt 1296 Ser Thr Ile Gly Pro Ile Leu Ala Ser Ser Val Gly Ile Arg Thr Val 420 425 430 gat gtt gga gct cca cag ctc tcg atg cat agc atc cgg gag atg tgt 1344 Asp Val Gly Ala Pro Gln Leu Ser Met His Ser Ile Arg Glu Met Cys 435 440 445 gct gcg gac gac gtg aag cat tca tac gag cac ttc aaa gct ttc ttc 1392 Ala Ala Asp Asp Val Lys His Ser Tyr Glu His Phe Lys Ala Phe Phe 450 455 460 caa gag ttc act cac ctt gac gcc aaa ctc act gtc gac gtt tga 1437 Gln Glu Phe Thr His Leu Asp Ala Lys Leu Thr Val Asp Val 465 470 475 <210> 399 <211> 478 <212> PRT <213> Brassica napus <400> 399 Met Ala Asn Thr Thr Ser Leu Val Ser Asp Phe Leu Ser Phe Leu Asn 1 5 10 15 Ala Ser Pro Thr Ala Phe His Ala Val Asp Glu Ser Lys Arg Arg Leu 20 25 30 Arg His Ala Gly Tyr Glu Gln Ile Ser Glu Arg Asp Asp Trp Lys Leu 35 40 45 Glu Ala Gly Lys Lys Tyr Phe Phe Thr Arg Asn Tyr Ser Thr Ile Val 50 55 60 Ala Phe Ala Val Gly Lys Lys Tyr Glu Ala Gly Asn Gly Phe His Ile 65 70 75 80 Ile Gly Ala His Thr Asp Ser Pro Cys Leu Lys Leu Lys Pro Val Ser 85 90 95 Lys Val Thr Lys Gly Gly Cys Leu Glu Val Gly Val Gln Thr Tyr Gly 100 105 110 Gly Gly Leu Trp Tyr Thr Trp Phe Asp Arg Asp Leu Thr Val Ala Gly 115 120 125 Arg Val Ile Val Lys Glu Asp Lys Ala Gly Ser Val Ser Tyr Ser His 130 135 140 Arg Leu Val Arg Ile Glu Asp Pro Ile Met Arg Ile Pro Thr Leu Ala 145 150 155 160 Ile His Leu Asp Arg Asn Val Asn Ser Glu Gly Phe Lys Pro Asn Thr 165 170 175 Gln Thr His Leu Val Pro Ile Leu Ala Thr Ala Ile Lys Ala Glu Leu 180 185 190 Asn Lys Val Pro Ala Glu Gly Gly Glu Glu Asp Gly Glu Lys Lys Cys 195 200 205 Thr Glu Ser Ser Ser Lys Ser Lys His His Pro Leu Leu Met Glu Ile 210 215 220 Ile Ala Asn Ala Leu Gly Cys Asn Pro Asp Glu Ile Cys Glu Phe Glu 225 230 235 240 Page 507 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Gln Val Cys Asp Thr Gln Pro Ser Ile Leu Gly Gly Ala Ala Lys 245 250 255 Glu Phe Ile Phe Ser Gly Arg Leu Asp Asn Leu Cys Met Ser Phe Cys 260 265 270 Ser Leu Lys Ala Leu Ile Asp Ala Thr Ser Ser Gly Ser Asp Leu Glu 275 280 285 Glu Glu Ser Gly Val Arg Met Val Ala Leu Phe Asp His Glu Glu Val 290 295 300 Gly Ser Asn Ser Ala Gln Gly Ala Gly Ser Pro Val Met Ile Asp Ala 305 310 315 320 Met Ser His Ile Thr Ser Cys Phe Ser Ser Asp Ala Lys Val Leu Lys 325 330 335 Lys Ala Ile Gln Lys Ser Leu Leu Val Ser Ala Asp Met Ala His Ala 340 345 350 Leu His Pro Asn Phe Met Asp Lys His Glu Glu Asn His Gln Pro Lys 355 360 365 Met His Gly Gly Leu Val Ile Lys His Asn Ala Asn Gln Arg Tyr Ala 370 375 380 Thr Asn Ala Val Thr Ser Phe Val Phe Arg Glu Ile Ala Glu Lys His 385 390 395 400 Asn Leu Pro Val Gln Asp Phe Val Val Arg Asn Asp Met Gly Cys Gly 405 410 415 Ser Thr Ile Gly Pro Ile Leu Ala Ser Ser Val Gly Ile Arg Thr Val 420 425 430 Asp Val Gly Ala Pro Gln Leu Ser Met His Ser Ile Arg Glu Met Cys 435 440 445 Ala Ala Asp Asp Val Lys His Ser Tyr Glu His Phe Lys Ala Phe Phe 450 455 460 Gln Glu Phe Thr His Leu Asp Ala Lys Leu Thr Val Asp Val 465 470 475 <210> 400 <211> 450 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(450) <400> 400 atg gca gat caa ctc acc gat gaa cag atc tcg gag ttc aag gaa gcc 48 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 ttc agt ttg ttc gat aag gat ggc gat ggt tgc atc aca aca aag gag 96 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 ctt ggg act gtt atg cgt tcg ttg ggt cag aat cca aca gag gct gag 144 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 ctc caa gac atg atc aat gaa gta gat gct gat ggg aat ggc acc att 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 gac ttc cct gag ttc ttg aac ctc atg gct aga aag atg aag gac act 240 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 gat tct gag gag gag ctg aaa gag gcg ttc cga gtg ttt gac aag gac 288 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 cag aat ggg ttc att tct gct gct gag ctc cgc cat gtg atg acc aac 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 ctt ggg gag aag ctc act gat gaa gag gtt gat gag atg att cga gag 384 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 gct gat gtc gat ggc gac ggc caa ata aac tac gag gag ttt gtt aag 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Page 508 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gtc atg atg gcc aag tga 450 Val Met Met Ala Lys 145 <210> 401 <211> 149 <212> PRT <213> Glycine max <400> 401 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Val Met Met Ala Lys 145 <210> 402 <211> 591 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(591) <400> 402 atg agt acg gca agg ttt atc aag tgt gta aca gtt gga gat ggt gct 48 Met Ser Thr Ala Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtg gga aag aca tgc atg ctt ata tcc tat acc agc aat acc ttt ccc 96 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gat tat gtt cca aca gtg ttt gac aat ttc agt gct aat gta acg 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Thr 35 40 45 gtg gat ggt agt act gtt aat ctt ggt tta tgg gac act gca gga caa 192 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gaa gat tac aac agg cta agg cct tta agc tat aga gga gct gat gtg 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttt ttg ttg tgc tat tct ctc atc agc aaa gcc agt tat gag aac atc 288 Phe Leu Leu Cys Tyr Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 tcc aaa aag tgg ata cct gag cta aga cat tat gct cca aat gtg cct 336 Ser Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Asn Val Pro 100 105 110 ata gtg ctg gtg gga aca aaa cta gat ttg cga gat gac aag caa ttt 384 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ctg att gat cat ccg gga tcc gca cga ata aca act gct cag ggt gaa 432 Leu Ile Asp His Pro Gly Ser Ala Arg Ile Thr Thr Ala Gln Gly Glu 130 135 140 Page 509 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa ttg aag aaa atg att ggt gca gtc act tat att gag tgc agc tcc 480 Glu Leu Lys Lys Met Ile Gly Ala Val Thr Tyr Ile Glu Cys Ser Ser 145 150 155 160 aaa aca cag ctg aat gtg aag aca gtt ttt gat gct gca ata aag gtt 528 Lys Thr Gln Leu Asn Val Lys Thr Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gca ttg aag cca cca aag cca aag aag aaa cca cgc aag aaa agg acc 576 Ala Leu Lys Pro Pro Lys Pro Lys Lys Lys Pro Arg Lys Lys Arg Thr 180 185 190 tgt act ttc ctc tga 591 Cys Thr Phe Leu 195 <210> 403 <211> 196 <212> PRT <213> Glycine max <400> 403 Met Ser Thr Ala Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Thr 35 40 45 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Leu Leu Cys Tyr Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 Ser Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Asn Val Pro 100 105 110 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Leu Ile Asp His Pro Gly Ser Ala Arg Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Lys Lys Met Ile Gly Ala Val Thr Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Leu Asn Val Lys Thr Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Ala Leu Lys Pro Pro Lys Pro Lys Lys Lys Pro Arg Lys Lys Arg Thr 180 185 190 Cys Thr Phe Leu 195 <210> 404 <211> 594 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(594) <400> 404 atg agc aca aca cgg ttt att aag tgt gtc aca gtt ggt gat ggg gct 48 Met Ser Thr Thr Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtg gga aag act tgc atg ctt atc tct tac act agc aac act ttc ccc 96 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gat tat gtt cct aca gtt ttc gac aat ttc agt gca aat gtt gtg 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtt gat ggc agc aca gtt aac ctg gga ttg tgg gac act gct gga cag 192 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Page 510 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gaa gat tac aac agg ctt agg cca ttg agt tac aga gga gca gat gtg 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc ttg ctg gcc ttt tcc ctc atc agc aaa gcc agc tat gaa aat ata 288 Phe Leu Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 tct aaa aag tgg att cct gaa ttg aga cat tat gcc cca act gtg cct 336 Ser Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Thr Val Pro 100 105 110 att gta ctg gtt gga act aaa ctt gat ttg agg gaa gac agg caa tat 384 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Arg Gln Tyr 115 120 125 ttg att gat cat cct gga acc aca gct ata gct act gcc cag gga gaa 432 Leu Ile Asp His Pro Gly Thr Thr Ala Ile Ala Thr Ala Gln Gly Glu 130 135 140 gaa ctg aag aag gca att ggt gct gct gtg tac ata gag tgc agc tca 480 Glu Leu Lys Lys Ala Ile Gly Ala Ala Val Tyr Ile Glu Cys Ser Ser 145 150 155 160 aag act cag cag aat gtg aag gcc gtg ttt gat gct gca atc aag gtt 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gtt ttg caa cca cct aag tcc aag aaa aaa gga aag aag aag aac acg 576 Val Leu Gln Pro Pro Lys Ser Lys Lys Lys Gly Lys Lys Lys Asn Thr 180 185 190 cct tgt gtt ttc ctc tga 594 Pro Cys Val Phe Leu 195 <210> 405 <211> 197 <212> PRT <213> Glycine max <400> 405 Met Ser Thr Thr Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Leu Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 Ser Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Thr Val Pro 100 105 110 Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Arg Gln Tyr 115 120 125 Leu Ile Asp His Pro Gly Thr Thr Ala Ile Ala Thr Ala Gln Gly Glu 130 135 140 Glu Leu Lys Lys Ala Ile Gly Ala Ala Val Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Val Leu Gln Pro Pro Lys Ser Lys Lys Lys Gly Lys Lys Lys Asn Thr 180 185 190 Pro Cys Val Phe Leu 195 <210> 406 <211> 591 <212> DNA <213> Glycine max <220> <221> CDS Page 511 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(591) <400> 406 atg agt gcg tcg agg ttc att aag tgc gtc acc gtc ggc gac ggt gct 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtc ggc aaa acc tgc ttg ttg att tcc tac acc agc aac act ttt ccc 96 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gac tat gtg ccc acc gtt ttt gac aat ttc agt gct aat gtg gtg 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtg gat gga agc acc gta aac cta gga ttg tgg gat aca gct ggt cag 192 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gag gat tac aat aga tta aga ccc ttg agc tat cga gga gct gat gtc 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc ata ctt gcc ttt tct ctc ata agc aag gct agc tat gaa aat att 288 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 gca aag aag tgg atc cct gaa cta agg cat tat gcc cct ggt gtt cca 336 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 ata att ctc gtt gga aca aag tta gat ctt cgg gat gat aag caa ttt 384 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttt atg gac cat cct ggt gca gtg cca att act aca gca cag gga gaa 432 Phe Met Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 gaa ttg aga aag ctg att ggt gct ccg gcc tac att gag tgt agt tcc 480 Glu Leu Arg Lys Leu Ile Gly Ala Pro Ala Tyr Ile Glu Cys Ser Ser 145 150 155 160 aaa acg caa cag aac gtg aaa gct gtc ttt gac gcg gca atc aaa gtg 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gtt atc caa cca cca aag cta aag aaa aag aga aaa aca cag aaa gct 576 Val Ile Gln Pro Pro Lys Leu Lys Lys Lys Arg Lys Thr Gln Lys Ala 180 185 190 tgc tcc ata tta tga 591 Cys Ser Ile Leu 195 <210> 407 <211> 196 <212> PRT <213> Glycine max <400> 407 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Ile 85 90 95 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Met Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Arg Lys Leu Ile Gly Ala Pro Ala Tyr Ile Glu Cys Ser Ser Page 512 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Val Ile Gln Pro Pro Lys Leu Lys Lys Lys Arg Lys Thr Gln Lys Ala 180 185 190 Cys Ser Ile Leu 195 <210> 408 <211> 1185 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(1185) <400> 408 atg tcg gac gat gaa agg gag gag aag gag ttg gat ctc tct tct gca 48 Met Ser Asp Asp Glu Arg Glu Glu Lys Glu Leu Asp Leu Ser Ser Ala 1 5 10 15 gaa gtt gta acc aaa tac aaa acc gcg gct gag atc gtt aac aag gcc 96 Glu Val Val Thr Lys Tyr Lys Thr Ala Ala Glu Ile Val Asn Lys Ala 20 25 30 ttg aag cta gtt att tca gaa tgt aaa cca aag gcg aag att gtg gat 144 Leu Lys Leu Val Ile Ser Glu Cys Lys Pro Lys Ala Lys Ile Val Asp 35 40 45 att tgt gag aaa ggg gat tca tac att cga gag caa act gga aat gtg 192 Ile Cys Glu Lys Gly Asp Ser Tyr Ile Arg Glu Gln Thr Gly Asn Val 50 55 60 tac aag aat gtg aag agg aag att gag aga ggt gtt gct ttc cct aca 240 Tyr Lys Asn Val Lys Arg Lys Ile Glu Arg Gly Val Ala Phe Pro Thr 65 70 75 80 tgt ttg tct gta aac aac gtt gtc tgc cat ttc tct cca cta gcc agt 288 Cys Leu Ser Val Asn Asn Val Val Cys His Phe Ser Pro Leu Ala Ser 85 90 95 gac gag gca gtg ttg gaa gaa ggt gat ata ttg aaa att gat atg gca 336 Asp Glu Ala Val Leu Glu Glu Gly Asp Ile Leu Lys Ile Asp Met Ala 100 105 110 tgt cat ata gat gga ttc att gct gcc gta gct cac acc cat gtt ctt 384 Cys His Ile Asp Gly Phe Ile Ala Ala Val Ala His Thr His Val Leu 115 120 125 cag gaa ggt cct gtt aca gga agg gca gct gat gtc att gct gcc gca 432 Gln Glu Gly Pro Val Thr Gly Arg Ala Ala Asp Val Ile Ala Ala Ala 130 135 140 aat act gct gct gag gtg gcc ttg agg ctt gtc agg cca gga aag aag 480 Asn Thr Ala Ala Glu Val Ala Leu Arg Leu Val Arg Pro Gly Lys Lys 145 150 155 160 aac aag gat gta agt gat gca att caa aag gtt gct gct gcc tat gac 528 Asn Lys Asp Val Ser Asp Ala Ile Gln Lys Val Ala Ala Ala Tyr Asp 165 170 175 tgt aaa atc gtt gag ggt gtt ctt agc cac caa atg aag cag ttt gtt 576 Cys Lys Ile Val Glu Gly Val Leu Ser His Gln Met Lys Gln Phe Val 180 185 190 att gat ggg aat aaa gtt gtg ctt agt ttg tct aat ccg gac aca agg 624 Ile Asp Gly Asn Lys Val Val Leu Ser Leu Ser Asn Pro Asp Thr Arg 195 200 205 gtt gac gaa gca gag ttt gag gag aat gaa gtt tat gca att gat ata 672 Val Asp Glu Ala Glu Phe Glu Glu Asn Glu Val Tyr Ala Ile Asp Ile 210 215 220 gta aca agc act ggg gac ggc aag cct aag ctg ttg gat gag aag cag 720 Val Thr Ser Thr Gly Asp Gly Lys Pro Lys Leu Leu Asp Glu Lys Gln 225 230 235 240 aca act atc tat aag agg gct gtt gac aag agt tat cac ttg aag atg 768 Thr Thr Ile Tyr Lys Arg Ala Val Asp Lys Ser Tyr His Leu Lys Met 245 250 255 aaa gcg tct agg ttc att ttc agt gaa ata agc caa aag ttt cct atc 816 Lys Ala Ser Arg Phe Ile Phe Ser Glu Ile Ser Gln Lys Phe Pro Ile Page 513 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 260 265 270 atg ccg ttc tct gct agg gct ttg gaa gag aaa aga gct cga ctt ggt 864 Met Pro Phe Ser Ala Arg Ala Leu Glu Glu Lys Arg Ala Arg Leu Gly 275 280 285 ttg gtg gaa tgc gtc aac cat gag ctc ttg cag cca tat cct gtt ttg 912 Leu Val Glu Cys Val Asn His Glu Leu Leu Gln Pro Tyr Pro Val Leu 290 295 300 cat gaa aag cct ggt gat ttg gtt gcg cac atc aaa ttc aca gtc ttg 960 His Glu Lys Pro Gly Asp Leu Val Ala His Ile Lys Phe Thr Val Leu 305 310 315 320 ttg atg cca aat gga tcg gat cga atc aca act cat cca ctc caa gaa 1008 Leu Met Pro Asn Gly Ser Asp Arg Ile Thr Thr His Pro Leu Gln Glu 325 330 335 ttg cag cct aca aaa aca ata gat gat cct gat att aag gcc tgg cta 1056 Leu Gln Pro Thr Lys Thr Ile Asp Asp Pro Asp Ile Lys Ala Trp Leu 340 345 350 gcc ttg ggc aca aag aca aag aag aaa ggt ggt ggg aag aag aaa aaa 1104 Ala Leu Gly Thr Lys Thr Lys Lys Lys Gly Gly Gly Lys Lys Lys Lys 355 360 365 ggt aag aaa ggg gac aag gca gat gag aca act gaa gct gag gct atg 1152 Gly Lys Lys Gly Asp Lys Ala Asp Glu Thr Thr Glu Ala Glu Ala Met 370 375 380 gac tca aca aac ggg gcc act cct caa gag tga 1185 Asp Ser Thr Asn Gly Ala Thr Pro Gln Glu 385 390 <210> 409 <211> 394 <212> PRT <213> Glycine max <400> 409 Met Ser Asp Asp Glu Arg Glu Glu Lys Glu Leu Asp Leu Ser Ser Ala 1 5 10 15 Glu Val Val Thr Lys Tyr Lys Thr Ala Ala Glu Ile Val Asn Lys Ala 20 25 30 Leu Lys Leu Val Ile Ser Glu Cys Lys Pro Lys Ala Lys Ile Val Asp 35 40 45 Ile Cys Glu Lys Gly Asp Ser Tyr Ile Arg Glu Gln Thr Gly Asn Val 50 55 60 Tyr Lys Asn Val Lys Arg Lys Ile Glu Arg Gly Val Ala Phe Pro Thr 65 70 75 80 Cys Leu Ser Val Asn Asn Val Val Cys His Phe Ser Pro Leu Ala Ser 85 90 95 Asp Glu Ala Val Leu Glu Glu Gly Asp Ile Leu Lys Ile Asp Met Ala 100 105 110 Cys His Ile Asp Gly Phe Ile Ala Ala Val Ala His Thr His Val Leu 115 120 125 Gln Glu Gly Pro Val Thr Gly Arg Ala Ala Asp Val Ile Ala Ala Ala 130 135 140 Asn Thr Ala Ala Glu Val Ala Leu Arg Leu Val Arg Pro Gly Lys Lys 145 150 155 160 Asn Lys Asp Val Ser Asp Ala Ile Gln Lys Val Ala Ala Ala Tyr Asp 165 170 175 Cys Lys Ile Val Glu Gly Val Leu Ser His Gln Met Lys Gln Phe Val 180 185 190 Ile Asp Gly Asn Lys Val Val Leu Ser Leu Ser Asn Pro Asp Thr Arg 195 200 205 Val Asp Glu Ala Glu Phe Glu Glu Asn Glu Val Tyr Ala Ile Asp Ile 210 215 220 Val Thr Ser Thr Gly Asp Gly Lys Pro Lys Leu Leu Asp Glu Lys Gln 225 230 235 240 Thr Thr Ile Tyr Lys Arg Ala Val Asp Lys Ser Tyr His Leu Lys Met 245 250 255 Lys Ala Ser Arg Phe Ile Phe Ser Glu Ile Ser Gln Lys Phe Pro Ile 260 265 270 Met Pro Phe Ser Ala Arg Ala Leu Glu Glu Lys Arg Ala Arg Leu Gly 275 280 285 Page 514 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Val Glu Cys Val Asn His Glu Leu Leu Gln Pro Tyr Pro Val Leu 290 295 300 His Glu Lys Pro Gly Asp Leu Val Ala His Ile Lys Phe Thr Val Leu 305 310 315 320 Leu Met Pro Asn Gly Ser Asp Arg Ile Thr Thr His Pro Leu Gln Glu 325 330 335 Leu Gln Pro Thr Lys Thr Ile Asp Asp Pro Asp Ile Lys Ala Trp Leu 340 345 350 Ala Leu Gly Thr Lys Thr Lys Lys Lys Gly Gly Gly Lys Lys Lys Lys 355 360 365 Gly Lys Lys Gly Asp Lys Ala Asp Glu Thr Thr Glu Ala Glu Ala Met 370 375 380 Asp Ser Thr Asn Gly Ala Thr Pro Gln Glu 385 390 <210> 410 <211> 765 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(765) <400> 410 atg gcc gtc gtt ggc gtc ctc gcg ctg caa gga tct ttc aac gaa cac 48 Met Ala Val Val Gly Val Leu Ala Leu Gln Gly Ser Phe Asn Glu His 1 5 10 15 ata gct gct ctt aga agg tta ggg gtg caa ggc gtg gag att cga aag 96 Ile Ala Ala Leu Arg Arg Leu Gly Val Gln Gly Val Glu Ile Arg Lys 20 25 30 cca gag cag ctt aac aca att agt tcc ctc att atc cct ggt gga gaa 144 Pro Glu Gln Leu Asn Thr Ile Ser Ser Leu Ile Ile Pro Gly Gly Glu 35 40 45 agc acc acc atg gct aag ctc gcc gag tat cac aac ctg ttt cct gct 192 Ser Thr Thr Met Ala Lys Leu Ala Glu Tyr His Asn Leu Phe Pro Ala 50 55 60 ttg cga gag ttt gta caa atg gga aag cct gtt tgg gga acc tgt gca 240 Leu Arg Glu Phe Val Gln Met Gly Lys Pro Val Trp Gly Thr Cys Ala 65 70 75 80 ggg ctt ata ttc ttg gca aat aaa gct ata gga cag aag act ggt ggt 288 Gly Leu Ile Phe Leu Ala Asn Lys Ala Ile Gly Gln Lys Thr Gly Gly 85 90 95 caa tat ttg gtt ggt gga ctt gat tgt aca gtg cat aga aat ttc ttt 336 Gln Tyr Leu Val Gly Gly Leu Asp Cys Thr Val His Arg Asn Phe Phe 100 105 110 ggc agc cag att caa agc ttt gag gca gag ctt tca gtg ccg gag ctt 384 Gly Ser Gln Ile Gln Ser Phe Glu Ala Glu Leu Ser Val Pro Glu Leu 115 120 125 gtc tcc aag gaa gga ggt cct gaa aca ttt tgt gga att ttt att cgt 432 Val Ser Lys Glu Gly Gly Pro Glu Thr Phe Cys Gly Ile Phe Ile Arg 130 135 140 gcc cct gca att ctt gaa gca ggg cca gaa gtt caa gtg ctg gct gat 480 Ala Pro Ala Ile Leu Glu Ala Gly Pro Glu Val Gln Val Leu Ala Asp 145 150 155 160 tat cct gta cct tct agc aga ttg ttg agt tct gat tcc tct att gaa 528 Tyr Pro Val Pro Ser Ser Arg Leu Leu Ser Ser Asp Ser Ser Ile Glu 165 170 175 gac caa acg gag aat gct gag aaa gaa agt aaa gtt ata gtt gct gtg 576 Asp Gln Thr Glu Asn Ala Glu Lys Glu Ser Lys Val Ile Val Ala Val 180 185 190 aga caa ggg aac ata tta gcc act gct ttc cat cct gaa ttg aca gcc 624 Arg Gln Gly Asn Ile Leu Ala Thr Ala Phe His Pro Glu Leu Thr Ala 195 200 205 gat act cga tgg cat agt tat ttc gta aaa atg tca aat gaa att aga 672 Asp Thr Arg Trp His Ser Tyr Phe Val Lys Met Ser Asn Glu Ile Arg 210 215 220 gaa gag gcc tct tcg agt agc ctt gtt cct gca caa gtc agt agt aca 720 Page 515 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Glu Ala Ser Ser Ser Ser Leu Val Pro Ala Gln Val Ser Ser Thr 225 230 235 240 agt caa tat caa cag ccc cgg aat gac ctt cct atc tat cga tag 765 Ser Gln Tyr Gln Gln Pro Arg Asn Asp Leu Pro Ile Tyr Arg 245 250 <210> 411 <211> 254 <212> PRT <213> Glycine max <400> 411 Met Ala Val Val Gly Val Leu Ala Leu Gln Gly Ser Phe Asn Glu His 1 5 10 15 Ile Ala Ala Leu Arg Arg Leu Gly Val Gln Gly Val Glu Ile Arg Lys 20 25 30 Pro Glu Gln Leu Asn Thr Ile Ser Ser Leu Ile Ile Pro Gly Gly Glu 35 40 45 Ser Thr Thr Met Ala Lys Leu Ala Glu Tyr His Asn Leu Phe Pro Ala 50 55 60 Leu Arg Glu Phe Val Gln Met Gly Lys Pro Val Trp Gly Thr Cys Ala 65 70 75 80 Gly Leu Ile Phe Leu Ala Asn Lys Ala Ile Gly Gln Lys Thr Gly Gly 85 90 95 Gln Tyr Leu Val Gly Gly Leu Asp Cys Thr Val His Arg Asn Phe Phe 100 105 110 Gly Ser Gln Ile Gln Ser Phe Glu Ala Glu Leu Ser Val Pro Glu Leu 115 120 125 Val Ser Lys Glu Gly Gly Pro Glu Thr Phe Cys Gly Ile Phe Ile Arg 130 135 140 Ala Pro Ala Ile Leu Glu Ala Gly Pro Glu Val Gln Val Leu Ala Asp 145 150 155 160 Tyr Pro Val Pro Ser Ser Arg Leu Leu Ser Ser Asp Ser Ser Ile Glu 165 170 175 Asp Gln Thr Glu Asn Ala Glu Lys Glu Ser Lys Val Ile Val Ala Val 180 185 190 Arg Gln Gly Asn Ile Leu Ala Thr Ala Phe His Pro Glu Leu Thr Ala 195 200 205 Asp Thr Arg Trp His Ser Tyr Phe Val Lys Met Ser Asn Glu Ile Arg 210 215 220 Glu Glu Ala Ser Ser Ser Ser Leu Val Pro Ala Gln Val Ser Ser Thr 225 230 235 240 Ser Gln Tyr Gln Gln Pro Arg Asn Asp Leu Pro Ile Tyr Arg 245 250 <210> 412 <211> 639 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(639) <400> 412 atg gct tcc gca act gcc cca aga ttc atc aag tgc gtg acc gtt ggt 48 Met Ala Ser Ala Thr Ala Pro Arg Phe Ile Lys Cys Val Thr Val Gly 1 5 10 15 gat gga gct gta ggg aag acc tgc atg ctc att tgc tat acc agc aac 96 Asp Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn 20 25 30 aaa ttc ccc acg gac tat atc ccc act gtg ttt gat aat ttc agt gca 144 Lys Phe Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser Ala 35 40 45 aat gtg gtt gtt gaa ggc ata act gtc aac tta ggc ctt tgg gat aca 192 Asn Val Val Val Glu Gly Ile Thr Val Asn Leu Gly Leu Trp Asp Thr 50 55 60 gct ggg caa gag gat tac aac agg ctg agg ccc ttg agc tac agg ggg 240 Page 516 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly 65 70 75 80 gca gat gtc ttt gtc ttg gct ttt tct tta gtt agt cgc gcg agc tat 288 Ala Asp Val Phe Val Leu Ala Phe Ser Leu Val Ser Arg Ala Ser Tyr 85 90 95 gag aat gtg ctg aag aag tgg atc cct gaa ctc cag cat ttt gcc cct 336 Glu Asn Val Leu Lys Lys Trp Ile Pro Glu Leu Gln His Phe Ala Pro 100 105 110 ggc atc ccg ttg gtg tta gtt ggc acc aaa ttg gat cta cga gaa gac 384 Gly Ile Pro Leu Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp 115 120 125 aag cac tac atg gct gat cat ccc agc ttg gtg cca gtg act act gat 432 Lys His Tyr Met Ala Asp His Pro Ser Leu Val Pro Val Thr Thr Asp 130 135 140 caa ggt gag gaa ctc cgt aaa cac att gga gct acc tac tat att gag 480 Gln Gly Glu Glu Leu Arg Lys His Ile Gly Ala Thr Tyr Tyr Ile Glu 145 150 155 160 tgc agc tca aaa act cag cag aat gtg aag gca gtt ttt gat gct gct 528 Cys Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala 165 170 175 att aga atg gtc atc aag cct cca caa aag caa aac gag aaa aga aag 576 Ile Arg Met Val Ile Lys Pro Pro Gln Lys Gln Asn Glu Lys Arg Lys 180 185 190 aaa aaa cca cgt ggc tgt ttc cta aac gtc ctc tgt cga agg aac att 624 Lys Lys Pro Arg Gly Cys Phe Leu Asn Val Leu Cys Arg Arg Asn Ile 195 200 205 gtt cgc ctt aaa tga 639 Val Arg Leu Lys 210 <210> 413 <211> 212 <212> PRT <213> Glycine max <400> 413 Met Ala Ser Ala Thr Ala Pro Arg Phe Ile Lys Cys Val Thr Val Gly 1 5 10 15 Asp Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn 20 25 30 Lys Phe Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser Ala 35 40 45 Asn Val Val Val Glu Gly Ile Thr Val Asn Leu Gly Leu Trp Asp Thr 50 55 60 Ala Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly 65 70 75 80 Ala Asp Val Phe Val Leu Ala Phe Ser Leu Val Ser Arg Ala Ser Tyr 85 90 95 Glu Asn Val Leu Lys Lys Trp Ile Pro Glu Leu Gln His Phe Ala Pro 100 105 110 Gly Ile Pro Leu Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp 115 120 125 Lys His Tyr Met Ala Asp His Pro Ser Leu Val Pro Val Thr Thr Asp 130 135 140 Gln Gly Glu Glu Leu Arg Lys His Ile Gly Ala Thr Tyr Tyr Ile Glu 145 150 155 160 Cys Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala 165 170 175 Ile Arg Met Val Ile Lys Pro Pro Gln Lys Gln Asn Glu Lys Arg Lys 180 185 190 Lys Lys Pro Arg Gly Cys Phe Leu Asn Val Leu Cys Arg Arg Asn Ile 195 200 205 Val Arg Leu Lys 210 <210> 414 <211> 786 <212> DNA Page 517 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Glycine max <220> <221> CDS <222> (1)..(786) <400> 414 atg gcc gtc gga aag aac aag cgc atc tcc aaa ggg aaa aag ggt ggc 48 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Lys Lys Gly Gly 1 5 10 15 aag aag aag gca gct gat ccc ttt gcc aag aag gat tgg tat gac att 96 Lys Lys Lys Ala Ala Asp Pro Phe Ala Lys Lys Asp Trp Tyr Asp Ile 20 25 30 aag gcc cct tct ctt ttt caa gtg aaa aat gtt ggc aaa acc ctc gtc 144 Lys Ala Pro Ser Leu Phe Gln Val Lys Asn Val Gly Lys Thr Leu Val 35 40 45 tct cgt acg cag ggt acc aag att gct tct gaa gga ctt aaa cat aga 192 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 gtg ttt gag gtc tcc ttg gct gat ctt caa ggg gat gag gat cat gca 240 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ala 65 70 75 80 ttc aag aag att agg ttg aga gct gaa gat gtg caa ggg aag aat gtc 288 Phe Lys Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Lys Asn Val 85 90 95 ctg aca aat ttc tgg gga atg gat ttc aca act gac aag ctg agg tca 336 Leu Thr Asn Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 ttg gtg cga aaa tgg caa act cta att gaa gcc cat gtg gat gtg aag 384 Leu Val Arg Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 aca act gat aac tac aca ttg agg atg ttt tgc att gga ttt acc aag 432 Thr Thr Asp Asn Tyr Thr Leu Arg Met Phe Cys Ile Gly Phe Thr Lys 130 135 140 aga aga gct aac caa gtg aag aga acc tgc tat gca caa tca agc cag 480 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 att aga cag att cgt agg aag atg agg gag atc atg acc aac cag gca 528 Ile Arg Gln Ile Arg Arg Lys Met Arg Glu Ile Met Thr Asn Gln Ala 165 170 175 aca tcc tgt gat ttg aag gag ttg gtc cgc aag ttt att cct gag att 576 Thr Ser Cys Asp Leu Lys Glu Leu Val Arg Lys Phe Ile Pro Glu Ile 180 185 190 att gga aaa gag att gag aag gcg aca tct agt att tac cct ctg cag 624 Ile Gly Lys Glu Ile Glu Lys Ala Thr Ser Ser Ile Tyr Pro Leu Gln 195 200 205 aat gtg ttt gtt cgt aaa gtc aag atc ctg aaa gcc cct aag ttt gat 672 Asn Val Phe Val Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 ctt ggg aaa ctg atg gag gtt cat gga gat tac tca gag gat gtt ggt 720 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Ser Glu Asp Val Gly 225 230 235 240 gcc aag gta gac aga cct gct gat gaa ata gtg gca gag gaa ccc act 768 Ala Lys Val Asp Arg Pro Ala Asp Glu Ile Val Ala Glu Glu Pro Thr 245 250 255 gaa att gtt gga gct tga 786 Glu Ile Val Gly Ala 260 <210> 415 <211> 261 <212> PRT <213> Glycine max <400> 415 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Lys Lys Gly Gly 1 5 10 15 Lys Lys Lys Ala Ala Asp Pro Phe Ala Lys Lys Asp Trp Tyr Asp Ile Page 518 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 Lys Ala Pro Ser Leu Phe Gln Val Lys Asn Val Gly Lys Thr Leu Val 35 40 45 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ala 65 70 75 80 Phe Lys Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Lys Asn Val 85 90 95 Leu Thr Asn Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Leu Val Arg Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 Thr Thr Asp Asn Tyr Thr Leu Arg Met Phe Cys Ile Gly Phe Thr Lys 130 135 140 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 Ile Arg Gln Ile Arg Arg Lys Met Arg Glu Ile Met Thr Asn Gln Ala 165 170 175 Thr Ser Cys Asp Leu Lys Glu Leu Val Arg Lys Phe Ile Pro Glu Ile 180 185 190 Ile Gly Lys Glu Ile Glu Lys Ala Thr Ser Ser Ile Tyr Pro Leu Gln 195 200 205 Asn Val Phe Val Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Ser Glu Asp Val Gly 225 230 235 240 Ala Lys Val Asp Arg Pro Ala Asp Glu Ile Val Ala Glu Glu Pro Thr 245 250 255 Glu Ile Val Gly Ala 260 <210> 416 <211> 594 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(594) <400> 416 atg agt gcg tcc agg ttc atc aag tgt gtc act gtg ggt gac ggt gcc 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtt ggc aag act tgc atg ctc atc tcc tac acc agc aac act ttt cct 96 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gac tac gtg cca act gtc ttt gac aat ttc agt gca aat gtc gtt 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtg gat gga agc act gtg aat ctt ggg ttg tgg gat act gct ggc caa 192 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gaa gat tac aat aga ttg aga ccc tta agc tat cgt gga gca gat gta 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc ctg ctt gct ttc tct ctc ata agc agg gcc agc tat gaa aat gtt 288 Phe Leu Leu Ala Phe Ser Leu Ile Ser Arg Ala Ser Tyr Glu Asn Val 85 90 95 gcc aag aaa tgg att cct gag ttg agg cat tat gct cct ggt gtt cca 336 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 att att ctt gtt gga aca aaa ctt gat ctt cgg gat gat aag cag ttc 384 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttt caa gac cat cct ggt gca gtg cct atc acc aca gca cag ggt gag 432 Phe Gln Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu Page 519 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 130 135 140 gaa ctg aga aag ctt atc ggt gct cca att tac att gaa tgt agt tca 480 Glu Leu Arg Lys Leu Ile Gly Ala Pro Ile Tyr Ile Glu Cys Ser Ser 145 150 155 160 aaa aca caa cag aat gtg aag gct gtt ttt gat gca gcc atc aag gta 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gtt ctc cag ccc cca aag cag aag aaa aag aag aga aag gga caa aag 576 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Arg Lys Gly Gln Lys 180 185 190 gcc tgt tcc att ttg tga 594 Ala Cys Ser Ile Leu 195 <210> 417 <211> 197 <212> PRT <213> Glycine max <400> 417 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Leu Leu Ala Phe Ser Leu Ile Ser Arg Ala Ser Tyr Glu Asn Val 85 90 95 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Gln Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Arg Lys Leu Ile Gly Ala Pro Ile Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Arg Lys Gly Gln Lys 180 185 190 Ala Cys Ser Ile Leu 195 <210> 418 <211> 1185 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(1185) <400> 418 atg cct ccc aaa tct gcc aaa tcc aag gaa gct cca gct gag cga ccc 48 Met Pro Pro Lys Ser Ala Lys Ser Lys Glu Ala Pro Ala Glu Arg Pro 1 5 10 15 atc ctc ggt cga ttc tct tct cac ctc aaa att ggc att gtt ggc ttg 96 Ile Leu Gly Arg Phe Ser Ser His Leu Lys Ile Gly Ile Val Gly Leu 20 25 30 cca aat gtt gga aag tct act ctc ttt aat act ctc acc aag ttg gca 144 Pro Asn Val Gly Lys Ser Thr Leu Phe Asn Thr Leu Thr Lys Leu Ala 35 40 45 ata cct gct gag aac ttc ccc ttt tgc acc att gag cct aat gag gca 192 Ile Pro Ala Glu Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Glu Ala Page 520 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 50 55 60 cgg gtc aat gta ccc gat gaa cgg ttc gag tgg ctt tgc caa tta ttc 240 Arg Val Asn Val Pro Asp Glu Arg Phe Glu Trp Leu Cys Gln Leu Phe 65 70 75 80 aag cca aaa agt gag gtc tcg gct ttc tta gaa atc cat gac ata gct 288 Lys Pro Lys Ser Glu Val Ser Ala Phe Leu Glu Ile His Asp Ile Ala 85 90 95 gga ttg gtc cga ggt gct cat cag ggg caa gga ttg ggg aat agt ttt 336 Gly Leu Val Arg Gly Ala His Gln Gly Gln Gly Leu Gly Asn Ser Phe 100 105 110 tta tct cac atc cgt gct gta gat ggc att ttc cat gtt tta cgt gca 384 Leu Ser His Ile Arg Ala Val Asp Gly Ile Phe His Val Leu Arg Ala 115 120 125 ttt gag gat ccg gac att att cac gtt gat gat act gtt gac cca gtc 432 Phe Glu Asp Pro Asp Ile Ile His Val Asp Asp Thr Val Asp Pro Val 130 135 140 agg gat tta gag gtc att act gaa gaa ttg cgg ctg aag gat att gaa 480 Arg Asp Leu Glu Val Ile Thr Glu Glu Leu Arg Leu Lys Asp Ile Glu 145 150 155 160 ttc atg gaa aga aag ata gaa gat att gag aaa agc atg aag agg agc 528 Phe Met Glu Arg Lys Ile Glu Asp Ile Glu Lys Ser Met Lys Arg Ser 165 170 175 aat gac aaa cag tta aaa atc gag ctt gaa tgt tgt caa agg gtg aag 576 Asn Asp Lys Gln Leu Lys Ile Glu Leu Glu Cys Cys Gln Arg Val Lys 180 185 190 gca ttg ctt gag gaa gga aaa gat ata cgt cta ggg gat tgg aag gct 624 Ala Leu Leu Glu Glu Gly Lys Asp Ile Arg Leu Gly Asp Trp Lys Ala 195 200 205 gct gat att gaa att ttg aat tcc ttt cag ttg ctg act gcc aag cct 672 Ala Asp Ile Glu Ile Leu Asn Ser Phe Gln Leu Leu Thr Ala Lys Pro 210 215 220 gtt gta tac ttg gtt aat atg aca gaa aaa gat tac caa aga aaa aag 720 Val Val Tyr Leu Val Asn Met Thr Glu Lys Asp Tyr Gln Arg Lys Lys 225 230 235 240 aac aag ttt ctg ccc aaa att cat gca tgg gtc caa gag cac ggt ggt 768 Asn Lys Phe Leu Pro Lys Ile His Ala Trp Val Gln Glu His Gly Gly 245 250 255 gag act att att cct ttc agc tgt gcc ttg gaa agg aat ctt gca gat 816 Glu Thr Ile Ile Pro Phe Ser Cys Ala Leu Glu Arg Asn Leu Ala Asp 260 265 270 atg cca cca gat gaa gct gct aag tat tgt gag gag aac aaa aca caa 864 Met Pro Pro Asp Glu Ala Ala Lys Tyr Cys Glu Glu Asn Lys Thr Gln 275 280 285 agt gct ctt acc aaa ata ata aag act gga ttt tca gct att aat ctc 912 Ser Ala Leu Thr Lys Ile Ile Lys Thr Gly Phe Ser Ala Ile Asn Leu 290 295 300 att tac ttt ttc act gca gga cct gat gag gtt aag tgt tgg caa att 960 Ile Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Lys Cys Trp Gln Ile 305 310 315 320 cga cgc caa aca aag gct ccc caa gct gca ggg gct atc cat act gat 1008 Arg Arg Gln Thr Lys Ala Pro Gln Ala Ala Gly Ala Ile His Thr Asp 325 330 335 ttt gaa aga gga ttt att tgt gct gag gtg atg aag ttt gag gat cta 1056 Phe Glu Arg Gly Phe Ile Cys Ala Glu Val Met Lys Phe Glu Asp Leu 340 345 350 aag gaa ctt ggt agt gag tca gct gtg aag gct gct gga aag tat aaa 1104 Lys Glu Leu Gly Ser Glu Ser Ala Val Lys Ala Ala Gly Lys Tyr Lys 355 360 365 cag gaa ggg aaa acg tat gtg gtc caa gat gga gac att ata ttc ttt 1152 Gln Glu Gly Lys Thr Tyr Val Val Gln Asp Gly Asp Ile Ile Phe Phe 370 375 380 aag ttc aac gtt tct ggt ggg ggc aag aag taa 1185 Lys Phe Asn Val Ser Gly Gly Gly Lys Lys 385 390 <210> 419 <211> 394 <212> PRT Page 521 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Glycine max <400> 419 Met Pro Pro Lys Ser Ala Lys Ser Lys Glu Ala Pro Ala Glu Arg Pro 1 5 10 15 Ile Leu Gly Arg Phe Ser Ser His Leu Lys Ile Gly Ile Val Gly Leu 20 25 30 Pro Asn Val Gly Lys Ser Thr Leu Phe Asn Thr Leu Thr Lys Leu Ala 35 40 45 Ile Pro Ala Glu Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Glu Ala 50 55 60 Arg Val Asn Val Pro Asp Glu Arg Phe Glu Trp Leu Cys Gln Leu Phe 65 70 75 80 Lys Pro Lys Ser Glu Val Ser Ala Phe Leu Glu Ile His Asp Ile Ala 85 90 95 Gly Leu Val Arg Gly Ala His Gln Gly Gln Gly Leu Gly Asn Ser Phe 100 105 110 Leu Ser His Ile Arg Ala Val Asp Gly Ile Phe His Val Leu Arg Ala 115 120 125 Phe Glu Asp Pro Asp Ile Ile His Val Asp Asp Thr Val Asp Pro Val 130 135 140 Arg Asp Leu Glu Val Ile Thr Glu Glu Leu Arg Leu Lys Asp Ile Glu 145 150 155 160 Phe Met Glu Arg Lys Ile Glu Asp Ile Glu Lys Ser Met Lys Arg Ser 165 170 175 Asn Asp Lys Gln Leu Lys Ile Glu Leu Glu Cys Cys Gln Arg Val Lys 180 185 190 Ala Leu Leu Glu Glu Gly Lys Asp Ile Arg Leu Gly Asp Trp Lys Ala 195 200 205 Ala Asp Ile Glu Ile Leu Asn Ser Phe Gln Leu Leu Thr Ala Lys Pro 210 215 220 Val Val Tyr Leu Val Asn Met Thr Glu Lys Asp Tyr Gln Arg Lys Lys 225 230 235 240 Asn Lys Phe Leu Pro Lys Ile His Ala Trp Val Gln Glu His Gly Gly 245 250 255 Glu Thr Ile Ile Pro Phe Ser Cys Ala Leu Glu Arg Asn Leu Ala Asp 260 265 270 Met Pro Pro Asp Glu Ala Ala Lys Tyr Cys Glu Glu Asn Lys Thr Gln 275 280 285 Ser Ala Leu Thr Lys Ile Ile Lys Thr Gly Phe Ser Ala Ile Asn Leu 290 295 300 Ile Tyr Phe Phe Thr Ala Gly Pro Asp Glu Val Lys Cys Trp Gln Ile 305 310 315 320 Arg Arg Gln Thr Lys Ala Pro Gln Ala Ala Gly Ala Ile His Thr Asp 325 330 335 Phe Glu Arg Gly Phe Ile Cys Ala Glu Val Met Lys Phe Glu Asp Leu 340 345 350 Lys Glu Leu Gly Ser Glu Ser Ala Val Lys Ala Ala Gly Lys Tyr Lys 355 360 365 Gln Glu Gly Lys Thr Tyr Val Val Gln Asp Gly Asp Ile Ile Phe Phe 370 375 380 Lys Phe Asn Val Ser Gly Gly Gly Lys Lys 385 390 <210> 420 <211> 993 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(993) <400> 420 atg cct tca att cca gaa gag cca ttg ttg gca ccg aac ccg gac cgg 48 Met Pro Ser Ile Pro Glu Glu Pro Leu Leu Ala Pro Asn Pro Asp Arg 1 5 10 15 ttc tgc atg ttc cca atc caa tat cct caa atc tgg gaa atg tac aag 96 Page 522 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Cys Met Phe Pro Ile Gln Tyr Pro Gln Ile Trp Glu Met Tyr Lys 20 25 30 aaa gcc gaa gcc tcg ttc tgg acg gcg gag gag gtg gac ctc tcg cag 144 Lys Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Gln 35 40 45 gac ctc cgc cac tgg gac tcc ctg acc gac ggc gag cgc cac ttc gtc 192 Asp Leu Arg His Trp Asp Ser Leu Thr Asp Gly Glu Arg His Phe Val 50 55 60 agt cac gtc ctc gcc ttc ttc gcc gcc tcc gac ggc atc gta ctt gag 240 Ser His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu 65 70 75 80 aac ctc gct ggg cgc ttc acg aag gaa atc caa atc ccc gag gcc cgc 288 Asn Leu Ala Gly Arg Phe Thr Lys Glu Ile Gln Ile Pro Glu Ala Arg 85 90 95 gcc ttc tac ggc ttc cag atc gcc atc gag aac att cac tcc gag atg 336 Ala Phe Tyr Gly Phe Gln Ile Ala Ile Glu Asn Ile His Ser Glu Met 100 105 110 tac agc ctc ctc ctc gaa acc tac atc aag gac tcc tcc cag aag agc 384 Tyr Ser Leu Leu Leu Glu Thr Tyr Ile Lys Asp Ser Ser Gln Lys Ser 115 120 125 cac ctc ttc cgc gcc atc gac acc atc ccg tgc gtt acc aag aaa gcc 432 His Leu Phe Arg Ala Ile Asp Thr Ile Pro Cys Val Thr Lys Lys Ala 130 135 140 cag tgg gcc cta cgc tgg atc gat tcc tcc gac tcc ttc gcc gag cgt 480 Gln Trp Ala Leu Arg Trp Ile Asp Ser Ser Asp Ser Phe Ala Glu Arg 145 150 155 160 ctc gtt gcc ttc gca tgt gtg gaa ggt atc ttc ttc tcc gga agc ttc 528 Leu Val Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe 165 170 175 tgc gct gtc ttc tgg ctc aaa aaa cgt gga ctc atg ccc gga ctc act 576 Cys Ala Val Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr 180 185 190 ttc tca aat gaa cta ata tca cgc gat gaa ggt ctt cat tgt gat ttc 624 Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe 195 200 205 gct tgt ctt tta tac tct ctg ctg aga cag aag ctc acc gag gag cgc 672 Ala Cys Leu Leu Tyr Ser Leu Leu Arg Gln Lys Leu Thr Glu Glu Arg 210 215 220 gta agg gag att gtg aag gac gcg gtg gac att gaa cgg gag ttt gtg 720 Val Arg Glu Ile Val Lys Asp Ala Val Asp Ile Glu Arg Glu Phe Val 225 230 235 240 tgc gac gcg ctt ccc tgc gcg ttg gtg ggg atg aac ggt gat ttg atg 768 Cys Asp Ala Leu Pro Cys Ala Leu Val Gly Met Asn Gly Asp Leu Met 245 250 255 agc cag tac att gaa ttt gtt gcg gat cgg ttg ctg ggt gcg cta ggg 816 Ser Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Leu Gly Ala Leu Gly 260 265 270 tgc ggg aag gtg tac aat gtt cag aat ccg ttc gat tgg atg gag ctc 864 Cys Gly Lys Val Tyr Asn Val Gln Asn Pro Phe Asp Trp Met Glu Leu 275 280 285 att tct ctg cag ggg aag acc aac ttc ttc gag aag cgc gtc ggg gaa 912 Ile Ser Leu Gln Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu 290 295 300 tat cag aag gct tct gtt atg tcc agc ttg aac ggg aac ggt ggt ggg 960 Tyr Gln Lys Ala Ser Val Met Ser Ser Leu Asn Gly Asn Gly Gly Gly 305 310 315 320 aac cac gtg ttc aag atg gat gag gat ttc taa 993 Asn His Val Phe Lys Met Asp Glu Asp Phe 325 330 <210> 421 <211> 330 <212> PRT <213> Glycine max <400> 421 Met Pro Ser Ile Pro Glu Glu Pro Leu Leu Ala Pro Asn Pro Asp Arg 1 5 10 15 Page 523 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Cys Met Phe Pro Ile Gln Tyr Pro Gln Ile Trp Glu Met Tyr Lys 20 25 30 Lys Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Gln 35 40 45 Asp Leu Arg His Trp Asp Ser Leu Thr Asp Gly Glu Arg His Phe Val 50 55 60 Ser His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu 65 70 75 80 Asn Leu Ala Gly Arg Phe Thr Lys Glu Ile Gln Ile Pro Glu Ala Arg 85 90 95 Ala Phe Tyr Gly Phe Gln Ile Ala Ile Glu Asn Ile His Ser Glu Met 100 105 110 Tyr Ser Leu Leu Leu Glu Thr Tyr Ile Lys Asp Ser Ser Gln Lys Ser 115 120 125 His Leu Phe Arg Ala Ile Asp Thr Ile Pro Cys Val Thr Lys Lys Ala 130 135 140 Gln Trp Ala Leu Arg Trp Ile Asp Ser Ser Asp Ser Phe Ala Glu Arg 145 150 155 160 Leu Val Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe 165 170 175 Cys Ala Val Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr 180 185 190 Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe 195 200 205 Ala Cys Leu Leu Tyr Ser Leu Leu Arg Gln Lys Leu Thr Glu Glu Arg 210 215 220 Val Arg Glu Ile Val Lys Asp Ala Val Asp Ile Glu Arg Glu Phe Val 225 230 235 240 Cys Asp Ala Leu Pro Cys Ala Leu Val Gly Met Asn Gly Asp Leu Met 245 250 255 Ser Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Leu Gly Ala Leu Gly 260 265 270 Cys Gly Lys Val Tyr Asn Val Gln Asn Pro Phe Asp Trp Met Glu Leu 275 280 285 Ile Ser Leu Gln Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu 290 295 300 Tyr Gln Lys Ala Ser Val Met Ser Ser Leu Asn Gly Asn Gly Gly Gly 305 310 315 320 Asn His Val Phe Lys Met Asp Glu Asp Phe 325 330 <210> 422 <211> 594 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(594) <400> 422 atg agc gct tct agg ttc atc aag tgc gtc act gtt ggg gat ggt gct 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtg ggc aaa acc tgt ttg ctt att tcc tac acc agc aac act ttt ccc 96 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acc gat tat gtg ccg act gtt ttt gac aat ttc agc gca aat gtg gtt 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtc aat ggg agc att gtg aat ctg ggt ttg tgg gat act gct gga caa 192 Val Asn Gly Ser Ile Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gag gat tat aac aga tta aga cct ttg agt tac cgt ggt gcc gat gtt 240 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc ata ctg gct ttc tct ctc ata agc aag gcc agt tat gaa aat gtc 288 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Val Page 524 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 tct aaa aag tgg att ccg gag ttg aag cat tat gct cct ggt gtc ccc 336 Ser Lys Lys Trp Ile Pro Glu Leu Lys His Tyr Ala Pro Gly Val Pro 100 105 110 att att ctg gtt ggc aca aag ctt gac ctt cgg gat gat aag cag ttc 384 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 tgc att gac cat cct ggt gcc gta cct att acc aca gct cag gga gaa 432 Cys Ile Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 gag ctt agg aag ctg att aat gcg cca gct tac att gaa tgc agt tca 480 Glu Leu Arg Lys Leu Ile Asn Ala Pro Ala Tyr Ile Glu Cys Ser Ser 145 150 155 160 aaa aca cag gag aac gtg aag gca gtc ttt gat gca gcc ata aga gtt 528 Lys Thr Gln Glu Asn Val Lys Ala Val Phe Asp Ala Ala Ile Arg Val 165 170 175 gtc ctt caa cca cct aag cag aag aaa aag aag ggt aaa gca caa aag 576 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Gly Lys Ala Gln Lys 180 185 190 gcc tgt tcg ata ttg tga 594 Ala Cys Ser Ile Leu 195 <210> 423 <211> 197 <212> PRT <213> Glycine max <400> 423 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Leu Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asn Gly Ser Ile Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Ile Leu Ala Phe Ser Leu Ile Ser Lys Ala Ser Tyr Glu Asn Val 85 90 95 Ser Lys Lys Trp Ile Pro Glu Leu Lys His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Cys Ile Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Arg Lys Leu Ile Asn Ala Pro Ala Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Glu Asn Val Lys Ala Val Phe Asp Ala Ala Ile Arg Val 165 170 175 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Gly Lys Ala Gln Lys 180 185 190 Ala Cys Ser Ile Leu 195 <210> 424 <211> 294 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(294) <400> 424 atg gcg aag cgc ttg att ccc tgc ttc aat cgc att ctc gtt gag aaa 48 Met Ala Lys Arg Leu Ile Pro Cys Phe Asn Arg Ile Leu Val Glu Lys Page 525 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 atc gtc cct ccc tcc aag aca agc gcc ggc att ctc ctc cct gag aag 96 Ile Val Pro Pro Ser Lys Thr Ser Ala Gly Ile Leu Leu Pro Glu Lys 20 25 30 tcc tcc cag ctt aat tcc ggt aag gtg ata gcg gtt ggg cct gga tca 144 Ser Ser Gln Leu Asn Ser Gly Lys Val Ile Ala Val Gly Pro Gly Ser 35 40 45 cgt gac cag gca ggg aac ttg att ccg gtg tcc gtg aag gaa ggt gat 192 Arg Asp Gln Ala Gly Asn Leu Ile Pro Val Ser Val Lys Glu Gly Asp 50 55 60 cac gtg ctc ttg ccg gag tac ggt ggc acg cag atc aag ctc gat gac 240 His Val Leu Leu Pro Glu Tyr Gly Gly Thr Gln Ile Lys Leu Asp Asp 65 70 75 80 aaa gag ttc cat ttg ttt agg gat gag gac atc ttg ggt att ctg cat 288 Lys Glu Phe His Leu Phe Arg Asp Glu Asp Ile Leu Gly Ile Leu His 85 90 95 gat tga 294 Asp <210> 425 <211> 97 <212> PRT <213> Glycine max <400> 425 Met Ala Lys Arg Leu Ile Pro Cys Phe Asn Arg Ile Leu Val Glu Lys 1 5 10 15 Ile Val Pro Pro Ser Lys Thr Ser Ala Gly Ile Leu Leu Pro Glu Lys 20 25 30 Ser Ser Gln Leu Asn Ser Gly Lys Val Ile Ala Val Gly Pro Gly Ser 35 40 45 Arg Asp Gln Ala Gly Asn Leu Ile Pro Val Ser Val Lys Glu Gly Asp 50 55 60 His Val Leu Leu Pro Glu Tyr Gly Gly Thr Gln Ile Lys Leu Asp Asp 65 70 75 80 Lys Glu Phe His Leu Phe Arg Asp Glu Asp Ile Leu Gly Ile Leu His 85 90 95 Asp <210> 426 <211> 990 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(990) <400> 426 atg cct tca att ccc gaa gag ccc ctc ctg gct ccg aac ccg gat cgc 48 Met Pro Ser Ile Pro Glu Glu Pro Leu Leu Ala Pro Asn Pro Asp Arg 1 5 10 15 ttc tgc atg ttc cca atc caa tac ccc caa atc tgg gaa atg tac aag 96 Phe Cys Met Phe Pro Ile Gln Tyr Pro Gln Ile Trp Glu Met Tyr Lys 20 25 30 aaa gcc gaa gcc tcg ttc tgg acg gcg gag gag gtg gac ctc tcc cag 144 Lys Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Gln 35 40 45 gac ctc cgc cac tgg gac tcc ctc acc gac ggc gag cgc cac ttc gtc 192 Asp Leu Arg His Trp Asp Ser Leu Thr Asp Gly Glu Arg His Phe Val 50 55 60 acc cac gtc ctc gcc ttc ttc gcc gcc tcc gac ggc atc gtc ctc gag 240 Thr His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu 65 70 75 80 aac ctc gcc ggg cgc ttc aca aag gag atc cag ctc ccc gag gcc cgg 288 Asn Leu Ala Gly Arg Phe Thr Lys Glu Ile Gln Leu Pro Glu Ala Arg Page 526 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 gcc ttc tac ggc ttc cag atc gcc atc gag aac atc cac tcc gag atg 336 Ala Phe Tyr Gly Phe Gln Ile Ala Ile Glu Asn Ile His Ser Glu Met 100 105 110 tac agc ctc ctc ctc gaa acc tac atc aag gac tcc gac cag aag aac 384 Tyr Ser Leu Leu Leu Glu Thr Tyr Ile Lys Asp Ser Asp Gln Lys Asn 115 120 125 cac ctc ttc cgt gcc atc gac acc atc ccc tgc gtc gct aag aaa gcc 432 His Leu Phe Arg Ala Ile Asp Thr Ile Pro Cys Val Ala Lys Lys Ala 130 135 140 cag tgg gcc ctt cgc tgg atc gat tcc tcc gac tcc ttc gcc gag cgt 480 Gln Trp Ala Leu Arg Trp Ile Asp Ser Ser Asp Ser Phe Ala Glu Arg 145 150 155 160 ctc gtt gcc ttc gca tgt gtt gaa ggt att ttc ttc tct gga agc ttc 528 Leu Val Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe 165 170 175 tgc gct atc ttc tgg ctc aaa aaa cga gga ctc atg ccg ggg ctc act 576 Cys Ala Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr 180 185 190 ttc tca aac gaa ctc att tct cgc gac gaa ggg cta cac tgc gat ttc 624 Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe 195 200 205 gcg tgt ctg ctc tac tct ctg ctg agg cag aag ctc acc gag gag cgc 672 Ala Cys Leu Leu Tyr Ser Leu Leu Arg Gln Lys Leu Thr Glu Glu Arg 210 215 220 gtg agg gag att gtg agg gac gcc gtg gat att gag cgg gag ttt gtc 720 Val Arg Glu Ile Val Arg Asp Ala Val Asp Ile Glu Arg Glu Phe Val 225 230 235 240 tgc gac gcg ctg ccc tgc gcg ttg gtg ggg atg aac ggt gat ttg atg 768 Cys Asp Ala Leu Pro Cys Ala Leu Val Gly Met Asn Gly Asp Leu Met 245 250 255 agt caa tac att gag ttt gtg gca gat cgg ttg ctg ggg gcg ctt ggg 816 Ser Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Leu Gly Ala Leu Gly 260 265 270 tgc ggg aag gtg tac aat gtt cag aac ccg ttc gat tgg atg gag ctg 864 Cys Gly Lys Val Tyr Asn Val Gln Asn Pro Phe Asp Trp Met Glu Leu 275 280 285 att tcg ctg cag gga aag acc aac ttc ttc gag aag cgc gtc ggg gag 912 Ile Ser Leu Gln Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu 290 295 300 tat caa aag gct tct gtt atg aac agc ttg aac ggg aac ggt ggg acc 960 Tyr Gln Lys Ala Ser Val Met Asn Ser Leu Asn Gly Asn Gly Gly Thr 305 310 315 320 cac gtc ttc aag atg gat gag gat ttc taa 990 His Val Phe Lys Met Asp Glu Asp Phe 325 <210> 427 <211> 329 <212> PRT <213> Glycine max <400> 427 Met Pro Ser Ile Pro Glu Glu Pro Leu Leu Ala Pro Asn Pro Asp Arg 1 5 10 15 Phe Cys Met Phe Pro Ile Gln Tyr Pro Gln Ile Trp Glu Met Tyr Lys 20 25 30 Lys Ala Glu Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Gln 35 40 45 Asp Leu Arg His Trp Asp Ser Leu Thr Asp Gly Glu Arg His Phe Val 50 55 60 Thr His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu 65 70 75 80 Asn Leu Ala Gly Arg Phe Thr Lys Glu Ile Gln Leu Pro Glu Ala Arg 85 90 95 Ala Phe Tyr Gly Phe Gln Ile Ala Ile Glu Asn Ile His Ser Glu Met 100 105 110 Tyr Ser Leu Leu Leu Glu Thr Tyr Ile Lys Asp Ser Asp Gln Lys Asn Page 527 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 115 120 125 His Leu Phe Arg Ala Ile Asp Thr Ile Pro Cys Val Ala Lys Lys Ala 130 135 140 Gln Trp Ala Leu Arg Trp Ile Asp Ser Ser Asp Ser Phe Ala Glu Arg 145 150 155 160 Leu Val Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe 165 170 175 Cys Ala Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr 180 185 190 Phe Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe 195 200 205 Ala Cys Leu Leu Tyr Ser Leu Leu Arg Gln Lys Leu Thr Glu Glu Arg 210 215 220 Val Arg Glu Ile Val Arg Asp Ala Val Asp Ile Glu Arg Glu Phe Val 225 230 235 240 Cys Asp Ala Leu Pro Cys Ala Leu Val Gly Met Asn Gly Asp Leu Met 245 250 255 Ser Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Leu Gly Ala Leu Gly 260 265 270 Cys Gly Lys Val Tyr Asn Val Gln Asn Pro Phe Asp Trp Met Glu Leu 275 280 285 Ile Ser Leu Gln Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Glu 290 295 300 Tyr Gln Lys Ala Ser Val Met Asn Ser Leu Asn Gly Asn Gly Gly Thr 305 310 315 320 His Val Phe Lys Met Asp Glu Asp Phe 325 <210> 428 <211> 1269 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(1269) <400> 428 atg gca aga gca gct tgc aat cac ctt cac ttg gtt ccc agt tta gtt 48 Met Ala Arg Ala Ala Cys Asn His Leu His Leu Val Pro Ser Leu Val 1 5 10 15 cat cct cta aag tca acc ctc ttc aca aat cac act ctt tcc acc aca 96 His Pro Leu Lys Ser Thr Leu Phe Thr Asn His Thr Leu Ser Thr Thr 20 25 30 cgc act cgc ttc tat ggc att cac cga agg ttc tct tct tct tca tcc 144 Arg Thr Arg Phe Tyr Gly Ile His Arg Arg Phe Ser Ser Ser Ser Ser 35 40 45 aaa ata agc atg agc ctc aag gct ggt att gtt ggc ctt ccc aac gtt 192 Lys Ile Ser Met Ser Leu Lys Ala Gly Ile Val Gly Leu Pro Asn Val 50 55 60 ggc aag tcc act ctc ttc aat gcc gtt gtg gaa aat gga aag gct caa 240 Gly Lys Ser Thr Leu Phe Asn Ala Val Val Glu Asn Gly Lys Ala Gln 65 70 75 80 gct gct aat ttt cca ttt tgt aca ata gag cca aat gta ggg att gtt 288 Ala Ala Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val 85 90 95 gct gtt cca gat tct cgt ctt cac gtg ctt tct gat ctc agc aaa tct 336 Ala Val Pro Asp Ser Arg Leu His Val Leu Ser Asp Leu Ser Lys Ser 100 105 110 caa cga gca gtt cca gca tca ata gag ttt gta gat att gct ggg ctt 384 Gln Arg Ala Val Pro Ala Ser Ile Glu Phe Val Asp Ile Ala Gly Leu 115 120 125 gtc aag ggt gca agt caa gga gag ttg cag ggt ttg ggc aat aag ttt 432 Val Lys Gly Ala Ser Gln Gly Glu Leu Gln Gly Leu Gly Asn Lys Phe 130 135 140 ttg tct cat att cgt gag gtg gac tct ata ctt cag gtt gta cga tgt 480 Leu Ser His Ile Arg Glu Val Asp Ser Ile Leu Gln Val Val Arg Cys 145 150 155 160 Page 528 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttt gaa gac aac gac att gtt cat gtg aat ggg aaa gtt gat ccc aag 528 Phe Glu Asp Asn Asp Ile Val His Val Asn Gly Lys Val Asp Pro Lys 165 170 175 tct gat att gat gtt atc aat ttg gag ctt gtt ttc tca gat ttg gac 576 Ser Asp Ile Asp Val Ile Asn Leu Glu Leu Val Phe Ser Asp Leu Asp 180 185 190 cag att gaa aaa aga att gat aag cta aag aaa ggc aag gca aag gat 624 Gln Ile Glu Lys Arg Ile Asp Lys Leu Lys Lys Gly Lys Ala Lys Asp 195 200 205 tca caa aaa ctc aag gaa gag gca gaa aag tct gca ctg gaa aag att 672 Ser Gln Lys Leu Lys Glu Glu Ala Glu Lys Ser Ala Leu Glu Lys Ile 210 215 220 cgt gag gcg ctt atg gat gga aaa cct gcg cga tct gtt acc tta act 720 Arg Glu Ala Leu Met Asp Gly Lys Pro Ala Arg Ser Val Thr Leu Thr 225 230 235 240 gat ttt gaa agg gat gct gta aag cat ctc tgc ttg ctc acc atg aaa 768 Asp Phe Glu Arg Asp Ala Val Lys His Leu Cys Leu Leu Thr Met Lys 245 250 255 cct gtt ata tat gtg gca aat gtt gca gaa tct gat cta gct gat cct 816 Pro Val Ile Tyr Val Ala Asn Val Ala Glu Ser Asp Leu Ala Asp Pro 260 265 270 gca aac aat aat tat gtc aag gac gta aca aat gtt gtg tct gag ttg 864 Ala Asn Asn Asn Tyr Val Lys Asp Val Thr Asn Val Val Ser Glu Leu 275 280 285 cag tcc aga att gta aca att tca gca cag gtt gag gca gag ctt act 912 Gln Ser Arg Ile Val Thr Ile Ser Ala Gln Val Glu Ala Glu Leu Thr 290 295 300 gaa cta cca gtt gaa gaa cga caa gaa tat ttg caa tct ctt ggt gtt 960 Glu Leu Pro Val Glu Glu Arg Gln Glu Tyr Leu Gln Ser Leu Gly Val 305 310 315 320 agt gaa agt ggt ctt ggc aac cta ata agg gca aca tat gac ctt ctg 1008 Ser Glu Ser Gly Leu Gly Asn Leu Ile Arg Ala Thr Tyr Asp Leu Leu 325 330 335 ggt ctc aga act tac ttt act tct ggt gag aag gag aca aag gca tgg 1056 Gly Leu Arg Thr Tyr Phe Thr Ser Gly Glu Lys Glu Thr Lys Ala Trp 340 345 350 aca ata ctt gca gga atg act gca cct caa gca gct gga gtt att cac 1104 Thr Ile Leu Ala Gly Met Thr Ala Pro Gln Ala Ala Gly Val Ile His 355 360 365 tct gac ttt gag aag ggt ttc att cga gca gag aca gtg tct tat gag 1152 Ser Asp Phe Glu Lys Gly Phe Ile Arg Ala Glu Thr Val Ser Tyr Glu 370 375 380 gat ttt gtt gct gct ggt tca ctt tct gca gca cga gag aaa gga ctg 1200 Asp Phe Val Ala Ala Gly Ser Leu Ser Ala Ala Arg Glu Lys Gly Leu 385 390 395 400 ttg aga tct gaa ggt aaa gac tac gtt gta caa gaa gca gat gtc atg 1248 Leu Arg Ser Glu Gly Lys Asp Tyr Val Val Gln Glu Ala Asp Val Met 405 410 415 ttg ttt cga ttc aat gtt tag 1269 Leu Phe Arg Phe Asn Val 420 <210> 429 <211> 422 <212> PRT <213> Glycine max <400> 429 Met Ala Arg Ala Ala Cys Asn His Leu His Leu Val Pro Ser Leu Val 1 5 10 15 His Pro Leu Lys Ser Thr Leu Phe Thr Asn His Thr Leu Ser Thr Thr 20 25 30 Arg Thr Arg Phe Tyr Gly Ile His Arg Arg Phe Ser Ser Ser Ser Ser 35 40 45 Lys Ile Ser Met Ser Leu Lys Ala Gly Ile Val Gly Leu Pro Asn Val 50 55 60 Gly Lys Ser Thr Leu Phe Asn Ala Val Val Glu Asn Gly Lys Ala Gln 65 70 75 80 Page 529 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Ala Asn Phe Pro Phe Cys Thr Ile Glu Pro Asn Val Gly Ile Val 85 90 95 Ala Val Pro Asp Ser Arg Leu His Val Leu Ser Asp Leu Ser Lys Ser 100 105 110 Gln Arg Ala Val Pro Ala Ser Ile Glu Phe Val Asp Ile Ala Gly Leu 115 120 125 Val Lys Gly Ala Ser Gln Gly Glu Leu Gln Gly Leu Gly Asn Lys Phe 130 135 140 Leu Ser His Ile Arg Glu Val Asp Ser Ile Leu Gln Val Val Arg Cys 145 150 155 160 Phe Glu Asp Asn Asp Ile Val His Val Asn Gly Lys Val Asp Pro Lys 165 170 175 Ser Asp Ile Asp Val Ile Asn Leu Glu Leu Val Phe Ser Asp Leu Asp 180 185 190 Gln Ile Glu Lys Arg Ile Asp Lys Leu Lys Lys Gly Lys Ala Lys Asp 195 200 205 Ser Gln Lys Leu Lys Glu Glu Ala Glu Lys Ser Ala Leu Glu Lys Ile 210 215 220 Arg Glu Ala Leu Met Asp Gly Lys Pro Ala Arg Ser Val Thr Leu Thr 225 230 235 240 Asp Phe Glu Arg Asp Ala Val Lys His Leu Cys Leu Leu Thr Met Lys 245 250 255 Pro Val Ile Tyr Val Ala Asn Val Ala Glu Ser Asp Leu Ala Asp Pro 260 265 270 Ala Asn Asn Asn Tyr Val Lys Asp Val Thr Asn Val Val Ser Glu Leu 275 280 285 Gln Ser Arg Ile Val Thr Ile Ser Ala Gln Val Glu Ala Glu Leu Thr 290 295 300 Glu Leu Pro Val Glu Glu Arg Gln Glu Tyr Leu Gln Ser Leu Gly Val 305 310 315 320 Ser Glu Ser Gly Leu Gly Asn Leu Ile Arg Ala Thr Tyr Asp Leu Leu 325 330 335 Gly Leu Arg Thr Tyr Phe Thr Ser Gly Glu Lys Glu Thr Lys Ala Trp 340 345 350 Thr Ile Leu Ala Gly Met Thr Ala Pro Gln Ala Ala Gly Val Ile His 355 360 365 Ser Asp Phe Glu Lys Gly Phe Ile Arg Ala Glu Thr Val Ser Tyr Glu 370 375 380 Asp Phe Val Ala Ala Gly Ser Leu Ser Ala Ala Arg Glu Lys Gly Leu 385 390 395 400 Leu Arg Ser Glu Gly Lys Asp Tyr Val Val Gln Glu Ala Asp Val Met 405 410 415 Leu Phe Arg Phe Asn Val 420 <210> 430 <211> 594 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(594) <400> 430 atg agt gcg tcc agg ttc atc aag tgt gtc act gtg ggt gac ggt gcc 48 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 gtt ggc aag act tgc atg ctc atc tcc tac acc agc aac act ttt cct 96 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 acg gac tac gtg cca act gtc ttt gac aat ttc agt gca aat gtc gtt 144 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 gtg gat gga agc act gtg aat ctt ggg ttg tgg gat act gct ggc caa 192 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 gaa gat tac aat aga ttg aga ccc tta agc tat cgt gga gca gat gta 240 Page 530 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 ttc ctg ctt gct ttc tct ctc ata agc agg gcc agc tat gaa aat gtt 288 Phe Leu Leu Ala Phe Ser Leu Ile Ser Arg Ala Ser Tyr Glu Asn Val 85 90 95 gcc aag aaa tgg att cct gag ttg agg cat tat gct cct ggt gtt cca 336 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 att att ctt gtt gga aca aaa ctt gat ctt cgg gat gat aag cag ttc 384 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 ttt caa gac cat cct ggt gca gtg cct atc acc aca gca cag ggt gag 432 Phe Gln Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 gaa ctg aga aag ctt atc ggt gct cca att tac att gaa tgt agt tca 480 Glu Leu Arg Lys Leu Ile Gly Ala Pro Ile Tyr Ile Glu Cys Ser Ser 145 150 155 160 aaa aca caa cag aat gtg aag gct gtt ttt gat gca gcc atc aag gta 528 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 gtt ctc cag ccc cca aag cag aag aaa aag aag aga aag gga caa aag 576 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Arg Lys Gly Gln Lys 180 185 190 gcc tgt tcc att ttg tga 594 Ala Cys Ser Ile Leu 195 <210> 431 <211> 197 <212> PRT <213> Glycine max <400> 431 Met Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp Gly Ala 1 5 10 15 Val Gly Lys Thr Cys Met Leu Ile Ser Tyr Thr Ser Asn Thr Phe Pro 20 25 30 Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val Val 35 40 45 Val Asp Gly Ser Thr Val Asn Leu Gly Leu Trp Asp Thr Ala Gly Gln 50 55 60 Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp Val 65 70 75 80 Phe Leu Leu Ala Phe Ser Leu Ile Ser Arg Ala Ser Tyr Glu Asn Val 85 90 95 Ala Lys Lys Trp Ile Pro Glu Leu Arg His Tyr Ala Pro Gly Val Pro 100 105 110 Ile Ile Leu Val Gly Thr Lys Leu Asp Leu Arg Asp Asp Lys Gln Phe 115 120 125 Phe Gln Asp His Pro Gly Ala Val Pro Ile Thr Thr Ala Gln Gly Glu 130 135 140 Glu Leu Arg Lys Leu Ile Gly Ala Pro Ile Tyr Ile Glu Cys Ser Ser 145 150 155 160 Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile Lys Val 165 170 175 Val Leu Gln Pro Pro Lys Gln Lys Lys Lys Lys Arg Lys Gly Gln Lys 180 185 190 Ala Cys Ser Ile Leu 195 <210> 432 <211> 756 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(756) Page 531 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 432 atg gca acc tct caa atc act gca tca ttg agg aac ttg cct gca ttt 48 Met Ala Thr Ser Gln Ile Thr Ala Ser Leu Arg Asn Leu Pro Ala Phe 1 5 10 15 gaa agg ttt caa cct tca gcg ctt cga ttt tct tct gct ggg cac gtc 96 Glu Arg Phe Gln Pro Ser Ala Leu Arg Phe Ser Ser Ala Gly His Val 20 25 30 aga att gga aca ctc acg caa ccc tcg ttt ccc tct ttc gtt gtc aaa 144 Arg Ile Gly Thr Leu Thr Gln Pro Ser Phe Pro Ser Phe Val Val Lys 35 40 45 gcc gcc act gtt gtt gcc ccc aag cac acc act gtt aag cct ctg ggt 192 Ala Ala Thr Val Val Ala Pro Lys His Thr Thr Val Lys Pro Leu Gly 50 55 60 gat aga gta ctg gtg aaa att aag gat gca gag gag aag act gca ggt 240 Asp Arg Val Leu Val Lys Ile Lys Asp Ala Glu Glu Lys Thr Ala Gly 65 70 75 80 ggg att tta ctg cca gca aat gct caa ggc aag cct caa ggg ggt gaa 288 Gly Ile Leu Leu Pro Ala Asn Ala Gln Gly Lys Pro Gln Gly Gly Glu 85 90 95 gtg gtt gct gtt gga gaa ggg aag tcg gtt ggg aag tgc aaa gtg gat 336 Val Val Ala Val Gly Glu Gly Lys Ser Val Gly Lys Cys Lys Val Asp 100 105 110 gtt agt gtg aag aca ggt gca caa gtt gtg cat tca aag tat gca ggg 384 Val Ser Val Lys Thr Gly Ala Gln Val Val His Ser Lys Tyr Ala Gly 115 120 125 act gag gta gag ttc aat ggt tca aaa cat ctt att ctg aag gac gat 432 Thr Glu Val Glu Phe Asn Gly Ser Lys His Leu Ile Leu Lys Asp Asp 130 135 140 gac att gtt ggt atc ctt gaa act gat gag gtc aag gat ctt aaa ccc 480 Asp Ile Val Gly Ile Leu Glu Thr Asp Glu Val Lys Asp Leu Lys Pro 145 150 155 160 ttg aac gat aga gtc ttg ata aag gtt gca gaa gct gag gaa aaa act 528 Leu Asn Asp Arg Val Leu Ile Lys Val Ala Glu Ala Glu Glu Lys Thr 165 170 175 gct gga ggt ttg ttg ctc aca gag gca acc aag gag aaa cca tct att 576 Ala Gly Gly Leu Leu Leu Thr Glu Ala Thr Lys Glu Lys Pro Ser Ile 180 185 190 gga aca gtg ata gca gtt ggt ccg ggg cct ctg gat gag gaa ggt aac 624 Gly Thr Val Ile Ala Val Gly Pro Gly Pro Leu Asp Glu Glu Gly Asn 195 200 205 aga aag cca ttg tcc gtc atg cct ggg aat aca gtt ctg tac tcc aga 672 Arg Lys Pro Leu Ser Val Met Pro Gly Asn Thr Val Leu Tyr Ser Arg 210 215 220 tat gca ggg aat gac ttc aag ggc aaa gat ggt tct gac tac att gcc 720 Tyr Ala Gly Asn Asp Phe Lys Gly Lys Asp Gly Ser Asp Tyr Ile Ala 225 230 235 240 ttg agg gcc tca gat gtc atg gct atc ctg tcc tag 756 Leu Arg Ala Ser Asp Val Met Ala Ile Leu Ser 245 250 <210> 433 <211> 251 <212> PRT <213> Glycine max <400> 433 Met Ala Thr Ser Gln Ile Thr Ala Ser Leu Arg Asn Leu Pro Ala Phe 1 5 10 15 Glu Arg Phe Gln Pro Ser Ala Leu Arg Phe Ser Ser Ala Gly His Val 20 25 30 Arg Ile Gly Thr Leu Thr Gln Pro Ser Phe Pro Ser Phe Val Val Lys 35 40 45 Ala Ala Thr Val Val Ala Pro Lys His Thr Thr Val Lys Pro Leu Gly 50 55 60 Asp Arg Val Leu Val Lys Ile Lys Asp Ala Glu Glu Lys Thr Ala Gly 65 70 75 80 Gly Ile Leu Leu Pro Ala Asn Ala Gln Gly Lys Pro Gln Gly Gly Glu Page 532 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Val Val Ala Val Gly Glu Gly Lys Ser Val Gly Lys Cys Lys Val Asp 100 105 110 Val Ser Val Lys Thr Gly Ala Gln Val Val His Ser Lys Tyr Ala Gly 115 120 125 Thr Glu Val Glu Phe Asn Gly Ser Lys His Leu Ile Leu Lys Asp Asp 130 135 140 Asp Ile Val Gly Ile Leu Glu Thr Asp Glu Val Lys Asp Leu Lys Pro 145 150 155 160 Leu Asn Asp Arg Val Leu Ile Lys Val Ala Glu Ala Glu Glu Lys Thr 165 170 175 Ala Gly Gly Leu Leu Leu Thr Glu Ala Thr Lys Glu Lys Pro Ser Ile 180 185 190 Gly Thr Val Ile Ala Val Gly Pro Gly Pro Leu Asp Glu Glu Gly Asn 195 200 205 Arg Lys Pro Leu Ser Val Met Pro Gly Asn Thr Val Leu Tyr Ser Arg 210 215 220 Tyr Ala Gly Asn Asp Phe Lys Gly Lys Asp Gly Ser Asp Tyr Ile Ala 225 230 235 240 Leu Arg Ala Ser Asp Val Met Ala Ile Leu Ser 245 250 <210> 434 <211> 429 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(429) <400> 434 atg atc cga ttc att ctg ttg cag aac agg cag ggc aag acc cgt ctt 48 Met Ile Arg Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 gcc aaa tac tac gtt cct ctc gag gat tcc gag aag cac aag gtg gaa 96 Ala Lys Tyr Tyr Val Pro Leu Glu Asp Ser Glu Lys His Lys Val Glu 20 25 30 tac gag gtt cac cgc ctc gtc gta aac aga gac cct aaa tac aca aat 144 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Pro Lys Tyr Thr Asn 35 40 45 ttc gtc gag ttt cgt acg cac aag ata ata tac agg cga tat gct ggg 192 Phe Val Glu Phe Arg Thr His Lys Ile Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 ttg ttt ttc tca atc tgt gtt gat atc act gat aat gag ttg gcg tat 240 Leu Phe Phe Ser Ile Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 tta gag tgc atc cat ttg ttt gtg gaa ata ttg gat cac ttc ttc agc 288 Leu Glu Cys Ile His Leu Phe Val Glu Ile Leu Asp His Phe Phe Ser 85 90 95 aat gtc tgt gag ctt gat ttg gtt ttt aac ttc cac aag gtc tat ctt 336 Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe His Lys Val Tyr Leu 100 105 110 ata ctt gat gaa ttc att cta gcg ggt gaa ctg caa gaa aca agc aag 384 Ile Leu Asp Glu Phe Ile Leu Ala Gly Glu Leu Gln Glu Thr Ser Lys 115 120 125 aag gct att att gag aga atg ggg gaa ctg gaa aaa cta gaa tga 429 Lys Ala Ile Ile Glu Arg Met Gly Glu Leu Glu Lys Leu Glu 130 135 140 <210> 435 <211> 142 <212> PRT <213> Glycine max <400> 435 Met Ile Arg Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 Page 533 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Lys Tyr Tyr Val Pro Leu Glu Asp Ser Glu Lys His Lys Val Glu 20 25 30 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Pro Lys Tyr Thr Asn 35 40 45 Phe Val Glu Phe Arg Thr His Lys Ile Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 Leu Phe Phe Ser Ile Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 Leu Glu Cys Ile His Leu Phe Val Glu Ile Leu Asp His Phe Phe Ser 85 90 95 Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe His Lys Val Tyr Leu 100 105 110 Ile Leu Asp Glu Phe Ile Leu Ala Gly Glu Leu Gln Glu Thr Ser Lys 115 120 125 Lys Ala Ile Ile Glu Arg Met Gly Glu Leu Glu Lys Leu Glu 130 135 140 <210> 436 <211> 342 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(342) <400> 436 atg tct gaa ttc gac aca aac atc cca act gct ttt gat ccc ttt gct 48 Met Ser Glu Phe Asp Thr Asn Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 gat gca aat gct gag gac tca ggt gct ggg acg aaa gag tat gtt cat 96 Asp Ala Asn Ala Glu Asp Ser Gly Ala Gly Thr Lys Glu Tyr Val His 20 25 30 gtt cgt gta caa cag cgc aac gga agg aaa agc cta aca act gtt caa 144 Val Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 ggt tta aag aaa gag tac agc tat agc aag ata ctc aag gac ctc aag 192 Gly Leu Lys Lys Glu Tyr Ser Tyr Ser Lys Ile Leu Lys Asp Leu Lys 50 55 60 aaa gaa ttc tgc tgt aat ggt act gtt gtc caa gac cct gag ttg ggc 240 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 cag gtc ata caa ctt cag ggt gat caa aga aag aat gtt tct act ttc 288 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 ctt atg cag gct ggc ata gta aag aag gaa tac atc aag ctt cat ggt 336 Leu Met Gln Ala Gly Ile Val Lys Lys Glu Tyr Ile Lys Leu His Gly 100 105 110 ttc taa 342 Phe <210> 437 <211> 113 <212> PRT <213> Glycine max <400> 437 Met Ser Glu Phe Asp Thr Asn Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 Asp Ala Asn Ala Glu Asp Ser Gly Ala Gly Thr Lys Glu Tyr Val His 20 25 30 Val Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 Gly Leu Lys Lys Glu Tyr Ser Tyr Ser Lys Ile Leu Lys Asp Leu Lys 50 55 60 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 Page 534 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 Leu Met Gln Ala Gly Ile Val Lys Lys Glu Tyr Ile Lys Leu His Gly 100 105 110 Phe <210> 438 <211> 339 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(339) <400> 438 atg gtt gat ttg gaa atc cag gtc ccc agc gca ttc gac ccg ttt gcc 48 Met Val Asp Leu Glu Ile Gln Val Pro Ser Ala Phe Asp Pro Phe Ala 1 5 10 15 gag gcg aga gaa tca gat gcc ccc ggg gca aag gag tat gtg cac ata 96 Glu Ala Arg Glu Ser Asp Ala Pro Gly Ala Lys Glu Tyr Val His Ile 20 25 30 cga att cag cag agg aat gga aag aag agt ctg aca aca gtg caa ggg 144 Arg Ile Gln Gln Arg Asn Gly Lys Lys Ser Leu Thr Thr Val Gln Gly 35 40 45 ctg aag aag gag ttc agc tac gag aag atc ctc aag gac ctc aag aag 192 Leu Lys Lys Glu Phe Ser Tyr Glu Lys Ile Leu Lys Asp Leu Lys Lys 50 55 60 gac ttc tgc tgc aac ggg act gtg gtg cag gac aag gag ctt ggc aag 240 Asp Phe Cys Cys Asn Gly Thr Val Val Gln Asp Lys Glu Leu Gly Lys 65 70 75 80 att atc caa ctc caa ggc gac cag cgc aag aac gta tcc cat ttc ctc 288 Ile Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser His Phe Leu 85 90 95 gtt cag gcc ggt ctt gtc cgg aag gac cag gtc aag att cat ggt ttt 336 Val Gln Ala Gly Leu Val Arg Lys Asp Gln Val Lys Ile His Gly Phe 100 105 110 tga 339 <210> 439 <211> 112 <212> PRT <213> Glycine max <400> 439 Met Val Asp Leu Glu Ile Gln Val Pro Ser Ala Phe Asp Pro Phe Ala 1 5 10 15 Glu Ala Arg Glu Ser Asp Ala Pro Gly Ala Lys Glu Tyr Val His Ile 20 25 30 Arg Ile Gln Gln Arg Asn Gly Lys Lys Ser Leu Thr Thr Val Gln Gly 35 40 45 Leu Lys Lys Glu Phe Ser Tyr Glu Lys Ile Leu Lys Asp Leu Lys Lys 50 55 60 Asp Phe Cys Cys Asn Gly Thr Val Val Gln Asp Lys Glu Leu Gly Lys 65 70 75 80 Ile Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser His Phe Leu 85 90 95 Val Gln Ala Gly Leu Val Arg Lys Asp Gln Val Lys Ile His Gly Phe 100 105 110 <210> 440 <211> 501 <212> DNA <213> Glycine max Page 535 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(501) <400> 440 atg ata aaa gca gtg ctg gtg ttg aac acg gag ggg aag cct cgt ctc 48 Met Ile Lys Ala Val Leu Val Leu Asn Thr Glu Gly Lys Pro Arg Leu 1 5 10 15 gcc aaa ttc tac caa ttt cag tct gtg gag aag cag cat gaa gct att 96 Ala Lys Phe Tyr Gln Phe Gln Ser Val Glu Lys Gln His Glu Ala Ile 20 25 30 cgc aat gtg ttt tca gtc tta tgc tgt aga cct gaa cat gtc agc aat 144 Arg Asn Val Phe Ser Val Leu Cys Cys Arg Pro Glu His Val Ser Asn 35 40 45 ttt gtg gat gcc gag tcc ttc ttt ggc ccg gac tct cgc ctt gtc tac 192 Phe Val Asp Ala Glu Ser Phe Phe Gly Pro Asp Ser Arg Leu Val Tyr 50 55 60 aag cac ttt gca act tta tat ttc atg ttc ata ttt gat agt tct gaa 240 Lys His Phe Ala Thr Leu Tyr Phe Met Phe Ile Phe Asp Ser Ser Glu 65 70 75 80 aac gag ctt gct atg ctt gac ttg ata caa gtg ttt gtt gaa aca ttg 288 Asn Glu Leu Ala Met Leu Asp Leu Ile Gln Val Phe Val Glu Thr Leu 85 90 95 gac aaa tgc ttc aga aat gta tgt gag ctt gat atc gtg ttc aac tat 336 Asp Lys Cys Phe Arg Asn Val Cys Glu Leu Asp Ile Val Phe Asn Tyr 100 105 110 agt aag atg cat acc ata cta gat gag atc att ctc gga ggc cag gtg 384 Ser Lys Met His Thr Ile Leu Asp Glu Ile Ile Leu Gly Gly Gln Val 115 120 125 ttg gag aca agt tca aac gag gtt atg aag gct att gaa gaa ata tca 432 Leu Glu Thr Ser Ser Asn Glu Val Met Lys Ala Ile Glu Glu Ile Ser 130 135 140 agg ctt gaa tca gca tcc aat gca atc aac ctt gtt cca aaa tct gtt 480 Arg Leu Glu Ser Ala Ser Asn Ala Ile Asn Leu Val Pro Lys Ser Val 145 150 155 160 tct ggt tgg agg tca cga taa 501 Ser Gly Trp Arg Ser Arg 165 <210> 441 <211> 166 <212> PRT <213> Glycine max <400> 441 Met Ile Lys Ala Val Leu Val Leu Asn Thr Glu Gly Lys Pro Arg Leu 1 5 10 15 Ala Lys Phe Tyr Gln Phe Gln Ser Val Glu Lys Gln His Glu Ala Ile 20 25 30 Arg Asn Val Phe Ser Val Leu Cys Cys Arg Pro Glu His Val Ser Asn 35 40 45 Phe Val Asp Ala Glu Ser Phe Phe Gly Pro Asp Ser Arg Leu Val Tyr 50 55 60 Lys His Phe Ala Thr Leu Tyr Phe Met Phe Ile Phe Asp Ser Ser Glu 65 70 75 80 Asn Glu Leu Ala Met Leu Asp Leu Ile Gln Val Phe Val Glu Thr Leu 85 90 95 Asp Lys Cys Phe Arg Asn Val Cys Glu Leu Asp Ile Val Phe Asn Tyr 100 105 110 Ser Lys Met His Thr Ile Leu Asp Glu Ile Ile Leu Gly Gly Gln Val 115 120 125 Leu Glu Thr Ser Ser Asn Glu Val Met Lys Ala Ile Glu Glu Ile Ser 130 135 140 Arg Leu Glu Ser Ala Ser Asn Ala Ile Asn Leu Val Pro Lys Ser Val 145 150 155 160 Ser Gly Trp Arg Ser Arg 165 Page 536 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 442 <211> 345 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(345) <400> 442 atg gtt gaa gtg ggt att tat cag atc cct acg agc act ttc gac cca 48 Met Val Glu Val Gly Ile Tyr Gln Ile Pro Thr Ser Thr Phe Asp Pro 1 5 10 15 ttt gcg gag gca aaa gaa aca gat gct ccc ggg gca aaa gag tat gtg 96 Phe Ala Glu Ala Lys Glu Thr Asp Ala Pro Gly Ala Lys Glu Tyr Val 20 25 30 cat atc cgc ata caa cag agg aat ggg aag aag agt ctg acc aca gtg 144 His Ile Arg Ile Gln Gln Arg Asn Gly Lys Lys Ser Leu Thr Thr Val 35 40 45 caa ggg ctg aag aaa gag ttc agc tac gag aag atc ctc aaa gac ctc 192 Gln Gly Leu Lys Lys Glu Phe Ser Tyr Glu Lys Ile Leu Lys Asp Leu 50 55 60 aag aaa gag ttc tgc tgc aat ggc aat gtt gtg cat gac aag gag ctt 240 Lys Lys Glu Phe Cys Cys Asn Gly Asn Val Val His Asp Lys Glu Leu 65 70 75 80 ggc aag att atc caa ctc cag ggt gat cag cgc aag aac gtt tct cac 288 Gly Lys Ile Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser His 85 90 95 ttc ctc att cat gct cgc ctt gtt agg aag gac cag atc aag att cat 336 Phe Leu Ile His Ala Arg Leu Val Arg Lys Asp Gln Ile Lys Ile His 100 105 110 ggt ttt taa 345 Gly Phe <210> 443 <211> 114 <212> PRT <213> Glycine max <400> 443 Met Val Glu Val Gly Ile Tyr Gln Ile Pro Thr Ser Thr Phe Asp Pro 1 5 10 15 Phe Ala Glu Ala Lys Glu Thr Asp Ala Pro Gly Ala Lys Glu Tyr Val 20 25 30 His Ile Arg Ile Gln Gln Arg Asn Gly Lys Lys Ser Leu Thr Thr Val 35 40 45 Gln Gly Leu Lys Lys Glu Phe Ser Tyr Glu Lys Ile Leu Lys Asp Leu 50 55 60 Lys Lys Glu Phe Cys Cys Asn Gly Asn Val Val His Asp Lys Glu Leu 65 70 75 80 Gly Lys Ile Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser His 85 90 95 Phe Leu Ile His Ala Arg Leu Val Arg Lys Asp Gln Ile Lys Ile His 100 105 110 Gly Phe <210> 444 <211> 342 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(342) <400> 444 Page 537 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atg tct gaa tta gac gat caa att cct act gcc ttc gat cct ttt gct 48 Met Ser Glu Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 gat gca aat gct gat gac tcg ggt gct ggg tca aag gag tat gtg cat 96 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 att cgc gta cag cag cga aat gga agg aaa agc ctg aca acc gtt cag 144 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 gga ttg aaa aaa gaa ttc agc tat aac aag ata ctt aaa gat gtt aag 192 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 aaa gag ttc tgt tgc aat gga aca gtt gtt cag gac cca gaa cta gga 240 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 cag gtt att caa ctt caa ggt gat cag agg aag aat gtt tct acc ttc 288 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 ctg gtc cag gct ggt atc gtg aag aag gag cat atc aag att cat ggt 336 Leu Val Gln Ala Gly Ile Val Lys Lys Glu His Ile Lys Ile His Gly 100 105 110 ttc tga 342 Phe <210> 445 <211> 113 <212> PRT <213> Glycine max <400> 445 Met Ser Glu Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 Leu Val Gln Ala Gly Ile Val Lys Lys Glu His Ile Lys Ile His Gly 100 105 110 Phe <210> 446 <211> 1503 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(1503) <400> 446 atg tcg ctg cct gct tgt ccc gcc gaa caa ctg gcc caa ctt ctc ggc 48 Met Ser Leu Pro Ala Cys Pro Ala Glu Gln Leu Ala Gln Leu Leu Gly 1 5 10 15 cca aac acc aca gac gcc tcc gcc gcc gcc tcc ctt atc tgc ggc cag 96 Pro Asn Thr Thr Asp Ala Ser Ala Ala Ala Ser Leu Ile Cys Gly Gln 20 25 30 ttc gcc gcc gtg gac agc aag ttc gtc gac acg gcc ttc gcc gtc gac 144 Phe Ala Ala Val Asp Ser Lys Phe Val Asp Thr Ala Phe Ala Val Asp 35 40 45 aac acc tac ctc ctc ttt tcc gcc tac ctc gtt ttt tct atg cag ctc 192 Page 538 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asn Thr Tyr Leu Leu Phe Ser Ala Tyr Leu Val Phe Ser Met Gln Leu 50 55 60 ggc ttc gcc atg ctc tgc gcc ggc tcc gtc cgc gcc aag aac acc atg 240 Gly Phe Ala Met Leu Cys Ala Gly Ser Val Arg Ala Lys Asn Thr Met 65 70 75 80 aac atc atg ctc acc aac gtc ctg gac gct gcc gcc ggc ggc ctc ttc 288 Asn Ile Met Leu Thr Asn Val Leu Asp Ala Ala Ala Gly Gly Leu Phe 85 90 95 tac tac ctc ttc ggc ttc gcc ttc gct ttc ggc tcc ccc tcc aac ggc 336 Tyr Tyr Leu Phe Gly Phe Ala Phe Ala Phe Gly Ser Pro Ser Asn Gly 100 105 110 ttc atc ggt aaa cat ttc ttc ggc ctc aag gac atc cct tca tcc tcc 384 Phe Ile Gly Lys His Phe Phe Gly Leu Lys Asp Ile Pro Ser Ser Ser 115 120 125 tac gac tac agc tac ttc ctc tac caa tgg gcc ttc gcc atc gcc gcc 432 Tyr Asp Tyr Ser Tyr Phe Leu Tyr Gln Trp Ala Phe Ala Ile Ala Ala 130 135 140 gcc ggc atc acc agc gga agc atc gcc gaa cgc aca cag ttc gtg gcc 480 Ala Gly Ile Thr Ser Gly Ser Ile Ala Glu Arg Thr Gln Phe Val Ala 145 150 155 160 tat ctc atc tac tcc tcc ttc ctc acc ggc ttc gtc tat ccg gtg gtc 528 Tyr Leu Ile Tyr Ser Ser Phe Leu Thr Gly Phe Val Tyr Pro Val Val 165 170 175 tcc cac tgg ttc tgg tcc cca gac ggc tgg gcc tct gcc ttt aag atc 576 Ser His Trp Phe Trp Ser Pro Asp Gly Trp Ala Ser Ala Phe Lys Ile 180 185 190 acc gac cgg cta ttt tcc acc ggc gta ata gac ttc gcc ggt tcc ggc 624 Thr Asp Arg Leu Phe Ser Thr Gly Val Ile Asp Phe Ala Gly Ser Gly 195 200 205 gta gtc cac atg gtc ggc gga ata gcc ggc cta tgg gga gcg ctg atc 672 Val Val His Met Val Gly Gly Ile Ala Gly Leu Trp Gly Ala Leu Ile 210 215 220 gaa ggc cca aga atg gga cgt ttc gat cat gca gga cga gct gtg gcc 720 Glu Gly Pro Arg Met Gly Arg Phe Asp His Ala Gly Arg Ala Val Ala 225 230 235 240 ttg cga ggc cac agc gcg tcc tta gta gtc ctg gga acc ttc ttg ctt 768 Leu Arg Gly His Ser Ala Ser Leu Val Val Leu Gly Thr Phe Leu Leu 245 250 255 tgg ttc ggt tgg tac gga ttt aac ccc ggt tca ttt aac aaa atc cta 816 Trp Phe Gly Trp Tyr Gly Phe Asn Pro Gly Ser Phe Asn Lys Ile Leu 260 265 270 ctt act tac ggt aac tca gga aat tac tac ggt caa tgg agc gcg gtt 864 Leu Thr Tyr Gly Asn Ser Gly Asn Tyr Tyr Gly Gln Trp Ser Ala Val 275 280 285 ggc aga acc gcg gtc acc act acc cta gcg ggg tca aca gct gcc ttg 912 Gly Arg Thr Ala Val Thr Thr Thr Leu Ala Gly Ser Thr Ala Ala Leu 290 295 300 acc acg cta ttc ggt aaa cgg gtg ata tcc ggt cac tgg aac gtg acc 960 Thr Thr Leu Phe Gly Lys Arg Val Ile Ser Gly His Trp Asn Val Thr 305 310 315 320 gat gtc tgc aac ggg ctg tta ggc ggt ttc gcg gcg ata aca gcc ggt 1008 Asp Val Cys Asn Gly Leu Leu Gly Gly Phe Ala Ala Ile Thr Ala Gly 325 330 335 tgc tcc gtg gtt gag cca tgg gca gcc atc gta tgc ggt ttt gtt gct 1056 Cys Ser Val Val Glu Pro Trp Ala Ala Ile Val Cys Gly Phe Val Ala 340 345 350 tct ata gta tta ata gct tgc aac aaa tta gca gag aag gtt aag ttc 1104 Ser Ile Val Leu Ile Ala Cys Asn Lys Leu Ala Glu Lys Val Lys Phe 355 360 365 gac gat cct ctg gag gcg gcg cag ttg cac ggt ggg tgt ggc acg tgg 1152 Asp Asp Pro Leu Glu Ala Ala Gln Leu His Gly Gly Cys Gly Thr Trp 370 375 380 ggg gtg ata ttc acg gcg ttg ttc gca aaa aag gag tat gtg aag gag 1200 Gly Val Ile Phe Thr Ala Leu Phe Ala Lys Lys Glu Tyr Val Lys Glu 385 390 395 400 gtt tac ggg ttg ggg agg gcg cac ggg ttg ctc atg ggg ggt ggt ggg 1248 Val Tyr Gly Leu Gly Arg Ala His Gly Leu Leu Met Gly Gly Gly Gly 405 410 415 Page 539 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aag ttg ctg gcg gcg cac gtg att cag att ctg gtg att gct ggg tgg 1296 Lys Leu Leu Ala Ala His Val Ile Gln Ile Leu Val Ile Ala Gly Trp 420 425 430 gtt agt gcg acc atg gga ccc ttg ttt tgg ggg ttg aat aaa ctg aag 1344 Val Ser Ala Thr Met Gly Pro Leu Phe Trp Gly Leu Asn Lys Leu Lys 435 440 445 ctg ttg agg att tct tca gag gat gag ctt gcg ggg atg gac atg act 1392 Leu Leu Arg Ile Ser Ser Glu Asp Glu Leu Ala Gly Met Asp Met Thr 450 455 460 cgc cat gga ggc ttt gct tat gct tat gag gat gat gag acg cac aag 1440 Arg His Gly Gly Phe Ala Tyr Ala Tyr Glu Asp Asp Glu Thr His Lys 465 470 475 480 cat ggg atg cag ttg agg agg gtt ggg ccc aac gcg tct tcc aca ccc 1488 His Gly Met Gln Leu Arg Arg Val Gly Pro Asn Ala Ser Ser Thr Pro 485 490 495 acc act gat gaa tga 1503 Thr Thr Asp Glu 500 <210> 447 <211> 500 <212> PRT <213> Glycine max <400> 447 Met Ser Leu Pro Ala Cys Pro Ala Glu Gln Leu Ala Gln Leu Leu Gly 1 5 10 15 Pro Asn Thr Thr Asp Ala Ser Ala Ala Ala Ser Leu Ile Cys Gly Gln 20 25 30 Phe Ala Ala Val Asp Ser Lys Phe Val Asp Thr Ala Phe Ala Val Asp 35 40 45 Asn Thr Tyr Leu Leu Phe Ser Ala Tyr Leu Val Phe Ser Met Gln Leu 50 55 60 Gly Phe Ala Met Leu Cys Ala Gly Ser Val Arg Ala Lys Asn Thr Met 65 70 75 80 Asn Ile Met Leu Thr Asn Val Leu Asp Ala Ala Ala Gly Gly Leu Phe 85 90 95 Tyr Tyr Leu Phe Gly Phe Ala Phe Ala Phe Gly Ser Pro Ser Asn Gly 100 105 110 Phe Ile Gly Lys His Phe Phe Gly Leu Lys Asp Ile Pro Ser Ser Ser 115 120 125 Tyr Asp Tyr Ser Tyr Phe Leu Tyr Gln Trp Ala Phe Ala Ile Ala Ala 130 135 140 Ala Gly Ile Thr Ser Gly Ser Ile Ala Glu Arg Thr Gln Phe Val Ala 145 150 155 160 Tyr Leu Ile Tyr Ser Ser Phe Leu Thr Gly Phe Val Tyr Pro Val Val 165 170 175 Ser His Trp Phe Trp Ser Pro Asp Gly Trp Ala Ser Ala Phe Lys Ile 180 185 190 Thr Asp Arg Leu Phe Ser Thr Gly Val Ile Asp Phe Ala Gly Ser Gly 195 200 205 Val Val His Met Val Gly Gly Ile Ala Gly Leu Trp Gly Ala Leu Ile 210 215 220 Glu Gly Pro Arg Met Gly Arg Phe Asp His Ala Gly Arg Ala Val Ala 225 230 235 240 Leu Arg Gly His Ser Ala Ser Leu Val Val Leu Gly Thr Phe Leu Leu 245 250 255 Trp Phe Gly Trp Tyr Gly Phe Asn Pro Gly Ser Phe Asn Lys Ile Leu 260 265 270 Leu Thr Tyr Gly Asn Ser Gly Asn Tyr Tyr Gly Gln Trp Ser Ala Val 275 280 285 Gly Arg Thr Ala Val Thr Thr Thr Leu Ala Gly Ser Thr Ala Ala Leu 290 295 300 Thr Thr Leu Phe Gly Lys Arg Val Ile Ser Gly His Trp Asn Val Thr 305 310 315 320 Asp Val Cys Asn Gly Leu Leu Gly Gly Phe Ala Ala Ile Thr Ala Gly 325 330 335 Cys Ser Val Val Glu Pro Trp Ala Ala Ile Val Cys Gly Phe Val Ala Page 540 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 340 345 350 Ser Ile Val Leu Ile Ala Cys Asn Lys Leu Ala Glu Lys Val Lys Phe 355 360 365 Asp Asp Pro Leu Glu Ala Ala Gln Leu His Gly Gly Cys Gly Thr Trp 370 375 380 Gly Val Ile Phe Thr Ala Leu Phe Ala Lys Lys Glu Tyr Val Lys Glu 385 390 395 400 Val Tyr Gly Leu Gly Arg Ala His Gly Leu Leu Met Gly Gly Gly Gly 405 410 415 Lys Leu Leu Ala Ala His Val Ile Gln Ile Leu Val Ile Ala Gly Trp 420 425 430 Val Ser Ala Thr Met Gly Pro Leu Phe Trp Gly Leu Asn Lys Leu Lys 435 440 445 Leu Leu Arg Ile Ser Ser Glu Asp Glu Leu Ala Gly Met Asp Met Thr 450 455 460 Arg His Gly Gly Phe Ala Tyr Ala Tyr Glu Asp Asp Glu Thr His Lys 465 470 475 480 His Gly Met Gln Leu Arg Arg Val Gly Pro Asn Ala Ser Ser Thr Pro 485 490 495 Thr Thr Asp Glu 500 <210> 448 <211> 342 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(342) <400> 448 atg tct gaa tta gac gat caa att cct act gcc ttc gat cct ttt gct 48 Met Ser Glu Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 gat gca aat gct gat gac tcg ggt gct ggg tca aag gag tat gtg cat 96 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 att cgt gta cag cag cga aat ggt agg aaa agc ctg aca acc gtt cag 144 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 gga ttg aaa aag gaa ttc agc tat aac aag ata ctt aaa gac gtc aag 192 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 aaa gag ttc tgt tgc aat gga aca gtt gtt cag gac cca gaa cta gga 240 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 cag gtt att caa ctt caa ggt gat cag agg aag aat gtt tct acc ttc 288 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 cta gtc cag gct ggt atc gtg aag aag gat cat atc aag att cat ggt 336 Leu Val Gln Ala Gly Ile Val Lys Lys Asp His Ile Lys Ile His Gly 100 105 110 ttc tga 342 Phe <210> 449 <211> 113 <212> PRT <213> Glycine max <400> 449 Met Ser Glu Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln Page 541 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 35 40 45 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 Leu Val Gln Ala Gly Ile Val Lys Lys Asp His Ile Lys Ile His Gly 100 105 110 Phe <210> 450 <211> 501 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(501) <400> 450 atg aag aat gca aag ggc aag gga gca gca agg gcc tca aaa gaa tca 48 Met Lys Asn Ala Lys Gly Lys Gly Ala Ala Arg Ala Ser Lys Glu Ser 1 5 10 15 ctg aag ccc gtt gat gac cga aag gtt gga aag cgg aag gct tcc ggt 96 Leu Lys Pro Val Asp Asp Arg Lys Val Gly Lys Arg Lys Ala Ser Gly 20 25 30 aag cct ggg aga agt agt gca cca aag aag gag aag aag gcc aag aaa 144 Lys Pro Gly Arg Ser Ser Ala Pro Lys Lys Glu Lys Lys Ala Lys Lys 35 40 45 gac ccc aac aag cct aaa aga cca ccc agt gct ttc ttt gtg ttc ctt 192 Asp Pro Asn Lys Pro Lys Arg Pro Pro Ser Ala Phe Phe Val Phe Leu 50 55 60 gag gag ttc agg aag acc ttt aag gct gag aat cct aat gtg aag gct 240 Glu Glu Phe Arg Lys Thr Phe Lys Ala Glu Asn Pro Asn Val Lys Ala 65 70 75 80 gta tca gtt gtt ggg aaa gct gga gga gag aaa tgg aaa tcc ttg tcc 288 Val Ser Val Val Gly Lys Ala Gly Gly Glu Lys Trp Lys Ser Leu Ser 85 90 95 agt gct gag aaa gct cca tat gaa gcc aag gct gcg aaa agg aaa gct 336 Ser Ala Glu Lys Ala Pro Tyr Glu Ala Lys Ala Ala Lys Arg Lys Ala 100 105 110 gag tat gaa aaa ctt atc aaa gct tat gat aaa aag cag gca agc tcc 384 Glu Tyr Glu Lys Leu Ile Lys Ala Tyr Asp Lys Lys Gln Ala Ser Ser 115 120 125 gca gat gat gaa gaa tca gac aag tcc aaa tct gaa gtg aat gat gaa 432 Ala Asp Asp Glu Glu Ser Asp Lys Ser Lys Ser Glu Val Asn Asp Glu 130 135 140 gat gat gcc agt gga gag gag gag gaa gag gat gat gag gag gaa gag 480 Asp Asp Ala Ser Gly Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu 145 150 155 160 gac gat gaa gat gat gac tga 501 Asp Asp Glu Asp Asp Asp 165 <210> 451 <211> 166 <212> PRT <213> Glycine max <400> 451 Met Lys Asn Ala Lys Gly Lys Gly Ala Ala Arg Ala Ser Lys Glu Ser 1 5 10 15 Leu Lys Pro Val Asp Asp Arg Lys Val Gly Lys Arg Lys Ala Ser Gly 20 25 30 Lys Pro Gly Arg Ser Ser Ala Pro Lys Lys Glu Lys Lys Ala Lys Lys 35 40 45 Page 542 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Pro Asn Lys Pro Lys Arg Pro Pro Ser Ala Phe Phe Val Phe Leu 50 55 60 Glu Glu Phe Arg Lys Thr Phe Lys Ala Glu Asn Pro Asn Val Lys Ala 65 70 75 80 Val Ser Val Val Gly Lys Ala Gly Gly Glu Lys Trp Lys Ser Leu Ser 85 90 95 Ser Ala Glu Lys Ala Pro Tyr Glu Ala Lys Ala Ala Lys Arg Lys Ala 100 105 110 Glu Tyr Glu Lys Leu Ile Lys Ala Tyr Asp Lys Lys Gln Ala Ser Ser 115 120 125 Ala Asp Asp Glu Glu Ser Asp Lys Ser Lys Ser Glu Val Asn Asp Glu 130 135 140 Asp Asp Ala Ser Gly Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu 145 150 155 160 Asp Asp Glu Asp Asp Asp 165 <210> 452 <211> 342 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(342) <400> 452 atg tct gga tta gac gat caa att cct act gcc ttc gat cct ttt gct 48 Met Ser Gly Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 gat gca aat gct gat gac tcg ggt gct ggg tca aag gag tat gtg cat 96 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 att cgc gtt cag cag cga aat ggt agg aaa agc ctg aca acc gtt cag 144 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 gga ttg aaa aaa gaa ttc agc tat aac aag ata ctt aaa gac gtt aag 192 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 aaa gag ttc tgt tgc aat gga aca gtt gtt cag gac cca gaa cta gga 240 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 cag gtt att caa ctt caa ggt gat cag agg aag aat gtt tct act ttc 288 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 cta gta cag gct ggt atc gtg aag aag gat cat atc aag att cat ggt 336 Leu Val Gln Ala Gly Ile Val Lys Lys Asp His Ile Lys Ile His Gly 100 105 110 ttc tga 342 Phe <210> 453 <211> 113 <212> PRT <213> Glycine max <400> 453 Met Ser Gly Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 Page 543 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 Leu Val Gln Ala Gly Ile Val Lys Lys Asp His Ile Lys Ile His Gly 100 105 110 Phe <210> 454 <211> 1086 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(1086) <400> 454 atg gct cag acc aca gcg aat cac aca gtg acc gta tct ggg tgg gca 48 Met Ala Gln Thr Thr Ala Asn His Thr Val Thr Val Ser Gly Trp Ala 1 5 10 15 gct cat gat tct tcg ggc aag att acc ccc tac act ttc aaa aga agg 96 Ala His Asp Ser Ser Gly Lys Ile Thr Pro Tyr Thr Phe Lys Arg Arg 20 25 30 gag aat ggt gtg aac gat gtg aca ata aag ata ctg tat tgt ggg atc 144 Glu Asn Gly Val Asn Asp Val Thr Ile Lys Ile Leu Tyr Cys Gly Ile 35 40 45 tgc cac acg gac ctc cac tat gct aaa aat gaa tgg ggc att act atg 192 Cys His Thr Asp Leu His Tyr Ala Lys Asn Glu Trp Gly Ile Thr Met 50 55 60 tat cct gta gta ccc gga cac gag atc att ggg gtg gta act aag gtg 240 Tyr Pro Val Val Pro Gly His Glu Ile Ile Gly Val Val Thr Lys Val 65 70 75 80 ggg aga gac gtg aag ggg ttc aag gaa gga gac aga gtg ggt gtg ggg 288 Gly Arg Asp Val Lys Gly Phe Lys Glu Gly Asp Arg Val Gly Val Gly 85 90 95 tgt ttg gcg gct tca tgt ttg gaa tgt gag cac tgc aag acc gat cag 336 Cys Leu Ala Ala Ser Cys Leu Glu Cys Glu His Cys Lys Thr Asp Gln 100 105 110 gaa aat tac tgt gaa aag ttg caa ttt gtc tac aac gga gta ttc tgg 384 Glu Asn Tyr Cys Glu Lys Leu Gln Phe Val Tyr Asn Gly Val Phe Trp 115 120 125 gat ggc agc atc acc tat ggg ggc tac tct caa att ttt gtc gca gat 432 Asp Gly Ser Ile Thr Tyr Gly Gly Tyr Ser Gln Ile Phe Val Ala Asp 130 135 140 tac aga tat gtg gta cac att ccg gaa aac cta gca atg gat gca gcg 480 Tyr Arg Tyr Val Val His Ile Pro Glu Asn Leu Ala Met Asp Ala Ala 145 150 155 160 gct cct ctg cta tgc gca gga ata aca gtg ttc aat cct ttg aaa gac 528 Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Phe Asn Pro Leu Lys Asp 165 170 175 cac gat ttg gta gca tca ccg gga aag aag att ggg gtg gtt ggt ctg 576 His Asp Leu Val Ala Ser Pro Gly Lys Lys Ile Gly Val Val Gly Leu 180 185 190 gga ggc ctt ggg cac att gcc gtt aaa ttt ggc aag gct ttc ggc cac 624 Gly Gly Leu Gly His Ile Ala Val Lys Phe Gly Lys Ala Phe Gly His 195 200 205 cat gtt acc gtc atc agc act tct ccc tcc aag gag gct gaa gct aag 672 His Val Thr Val Ile Ser Thr Ser Pro Ser Lys Glu Ala Glu Ala Lys 210 215 220 cag cgt ttg ggt gct gat gat ttc att gtc agc tcc aac cct aaa caa 720 Gln Arg Leu Gly Ala Asp Asp Phe Ile Val Ser Ser Asn Pro Lys Gln 225 230 235 240 tta cag gct gca agg aga agc ata gat ttc ata ttg gac act gtt tcg 768 Leu Gln Ala Ala Arg Arg Ser Ile Asp Phe Ile Leu Asp Thr Val Ser 245 250 255 gca gag cac tct ctg ttg ccc atc ttg gaa ttg ctc aaa gtc aac ggg 816 Ala Glu His Ser Leu Leu Pro Ile Leu Glu Leu Leu Lys Val Asn Gly 260 265 270 Page 544 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt acc tta ttt ctc gtg ggt gca cca gac aag ccc tta caa ttg cca gct 864 Thr Leu Phe Leu Val Gly Ala Pro Asp Lys Pro Leu Gln Leu Pro Ala 275 280 285 ttc cca ttg ata ttt ggc aag aga tca gtg aaa ggt ggg atc ata ggg 912 Phe Pro Leu Ile Phe Gly Lys Arg Ser Val Lys Gly Gly Ile Ile Gly 290 295 300 gga ata aaa gag acg cag gaa atg ttg gag gtt tgt gca aag tac aat 960 Gly Ile Lys Glu Thr Gln Glu Met Leu Glu Val Cys Ala Lys Tyr Asn 305 310 315 320 ata acg agt gac att gaa tta atc aca cca gac aga atc aac gag gct 1008 Ile Thr Ser Asp Ile Glu Leu Ile Thr Pro Asp Arg Ile Asn Glu Ala 325 330 335 atg gag cgc ctt gct aag aat gat gtg cgc tac cgt ttc gtc att gat 1056 Met Glu Arg Leu Ala Lys Asn Asp Val Arg Tyr Arg Phe Val Ile Asp 340 345 350 att gct aat gct gcc gct tcc aac aac taa 1086 Ile Ala Asn Ala Ala Ala Ser Asn Asn 355 360 <210> 455 <211> 361 <212> PRT <213> Glycine max <400> 455 Met Ala Gln Thr Thr Ala Asn His Thr Val Thr Val Ser Gly Trp Ala 1 5 10 15 Ala His Asp Ser Ser Gly Lys Ile Thr Pro Tyr Thr Phe Lys Arg Arg 20 25 30 Glu Asn Gly Val Asn Asp Val Thr Ile Lys Ile Leu Tyr Cys Gly Ile 35 40 45 Cys His Thr Asp Leu His Tyr Ala Lys Asn Glu Trp Gly Ile Thr Met 50 55 60 Tyr Pro Val Val Pro Gly His Glu Ile Ile Gly Val Val Thr Lys Val 65 70 75 80 Gly Arg Asp Val Lys Gly Phe Lys Glu Gly Asp Arg Val Gly Val Gly 85 90 95 Cys Leu Ala Ala Ser Cys Leu Glu Cys Glu His Cys Lys Thr Asp Gln 100 105 110 Glu Asn Tyr Cys Glu Lys Leu Gln Phe Val Tyr Asn Gly Val Phe Trp 115 120 125 Asp Gly Ser Ile Thr Tyr Gly Gly Tyr Ser Gln Ile Phe Val Ala Asp 130 135 140 Tyr Arg Tyr Val Val His Ile Pro Glu Asn Leu Ala Met Asp Ala Ala 145 150 155 160 Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Phe Asn Pro Leu Lys Asp 165 170 175 His Asp Leu Val Ala Ser Pro Gly Lys Lys Ile Gly Val Val Gly Leu 180 185 190 Gly Gly Leu Gly His Ile Ala Val Lys Phe Gly Lys Ala Phe Gly His 195 200 205 His Val Thr Val Ile Ser Thr Ser Pro Ser Lys Glu Ala Glu Ala Lys 210 215 220 Gln Arg Leu Gly Ala Asp Asp Phe Ile Val Ser Ser Asn Pro Lys Gln 225 230 235 240 Leu Gln Ala Ala Arg Arg Ser Ile Asp Phe Ile Leu Asp Thr Val Ser 245 250 255 Ala Glu His Ser Leu Leu Pro Ile Leu Glu Leu Leu Lys Val Asn Gly 260 265 270 Thr Leu Phe Leu Val Gly Ala Pro Asp Lys Pro Leu Gln Leu Pro Ala 275 280 285 Phe Pro Leu Ile Phe Gly Lys Arg Ser Val Lys Gly Gly Ile Ile Gly 290 295 300 Gly Ile Lys Glu Thr Gln Glu Met Leu Glu Val Cys Ala Lys Tyr Asn 305 310 315 320 Ile Thr Ser Asp Ile Glu Leu Ile Thr Pro Asp Arg Ile Asn Glu Ala 325 330 335 Met Glu Arg Leu Ala Lys Asn Asp Val Arg Tyr Arg Phe Val Ile Asp Page 545 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 340 345 350 Ile Ala Asn Ala Ala Ala Ser Asn Asn 355 360 <210> 456 <211> 1659 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(1659) <400> 456 atg gca tca act act ctc ttc agc ttc aga ctc tct ttg aac cca ctg 48 Met Ala Ser Thr Thr Leu Phe Ser Phe Arg Leu Ser Leu Asn Pro Leu 1 5 10 15 cac cat caa cag aca acg agg cca aaa tct ctg ctc tcc tct cct cgc 96 His His Gln Gln Thr Thr Arg Pro Lys Ser Leu Leu Ser Ser Pro Arg 20 25 30 acc aat cca cgc ctc gtt tct tcc att aac aat cat ttg gcc ctc aca 144 Thr Asn Pro Arg Leu Val Ser Ser Ile Asn Asn His Leu Ala Leu Thr 35 40 45 cgt gtc aca tac ccg ctt ctc caa tct cac tct gct cct aag cgc aga 192 Arg Val Thr Tyr Pro Leu Leu Gln Ser His Ser Ala Pro Lys Arg Arg 50 55 60 ttc cat gtg tat tct gat ggg gaa agc tcc gag tcg ctt gtt tct gac 240 Phe His Val Tyr Ser Asp Gly Glu Ser Ser Glu Ser Leu Val Ser Asp 65 70 75 80 gct aca tac caa gag gaa ttt tct tgg tct tct gta att ctt ccg ttt 288 Ala Thr Tyr Gln Glu Glu Phe Ser Trp Ser Ser Val Ile Leu Pro Phe 85 90 95 ctg ttc cct gcg ttg ggt ggc tta tta ttt ggc tat gat att gga gcc 336 Leu Phe Pro Ala Leu Gly Gly Leu Leu Phe Gly Tyr Asp Ile Gly Ala 100 105 110 acc tct ggc gct aca att tca ctg cag tca cct gag ctt agc ggt ata 384 Thr Ser Gly Ala Thr Ile Ser Leu Gln Ser Pro Glu Leu Ser Gly Ile 115 120 125 tca tgg ttt aaa ctt tct gct att cag ctt gga cta gtg gtt agt ggt 432 Ser Trp Phe Lys Leu Ser Ala Ile Gln Leu Gly Leu Val Val Ser Gly 130 135 140 tcc cta tat ggg gct ctt ctt ggc tcg ctt gtt gca ttt gcc ata gct 480 Ser Leu Tyr Gly Ala Leu Leu Gly Ser Leu Val Ala Phe Ala Ile Ala 145 150 155 160 gat ttc ctt ggg agg aag aaa caa ctc att act gca gca ctg ttg tat 528 Asp Phe Leu Gly Arg Lys Lys Gln Leu Ile Thr Ala Ala Leu Leu Tyr 165 170 175 ttg ttt ggt ggt gtg att act gcc tat gca cca gaa ctt ggt gtt ctc 576 Leu Phe Gly Gly Val Ile Thr Ala Tyr Ala Pro Glu Leu Gly Val Leu 180 185 190 tta gca gga agg ctg ctt tat gga ctt ggt ata ggt ttg gcc atg cat 624 Leu Ala Gly Arg Leu Leu Tyr Gly Leu Gly Ile Gly Leu Ala Met His 195 200 205 ggg gct cct tta tat att gcg gag act tgt cca tca caa atc cgt ggg 672 Gly Ala Pro Leu Tyr Ile Ala Glu Thr Cys Pro Ser Gln Ile Arg Gly 210 215 220 act tta gta tca tta aaa gaa ctc ttc att gtc ctg ggg att ctg ctg 720 Thr Leu Val Ser Leu Lys Glu Leu Phe Ile Val Leu Gly Ile Leu Leu 225 230 235 240 ggt tat ttt gtg gga agc ttt ctg att gag acc gtt ggg gga tgg cgg 768 Gly Tyr Phe Val Gly Ser Phe Leu Ile Glu Thr Val Gly Gly Trp Arg 245 250 255 ttc atg tat gga ttt agt gct cca gtt gct gta tta atg ggg ctt gga 816 Phe Met Tyr Gly Phe Ser Ala Pro Val Ala Val Leu Met Gly Leu Gly 260 265 270 atg ttg act ctc ccc aat tct cca cgg tgg ttg ctt ctc aga gca gtg 864 Met Leu Thr Leu Pro Asn Ser Pro Arg Trp Leu Leu Leu Arg Ala Val 275 280 285 Page 546 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt caa gga aaa ggt tct ttt caa gat ttg aag gaa aag gcc att ttt tcc 912 Gln Gly Lys Gly Ser Phe Gln Asp Leu Lys Glu Lys Ala Ile Phe Ser 290 295 300 ctg agc aaa tta agg ggc cga cca cct ggt gac aaa gaa tcc gag aga 960 Leu Ser Lys Leu Arg Gly Arg Pro Pro Gly Asp Lys Glu Ser Glu Arg 305 310 315 320 caa gta gaa gaa acc ctt gtc tca ttg aag tct gcc tat gca gat aag 1008 Gln Val Glu Glu Thr Leu Val Ser Leu Lys Ser Ala Tyr Ala Asp Lys 325 330 335 gaa tcg gag ggg aat ttc tta gag gtg ttt cag ggt ccg aat ctg aaa 1056 Glu Ser Glu Gly Asn Phe Leu Glu Val Phe Gln Gly Pro Asn Leu Lys 340 345 350 gct ttc ata att ggt ggg gga cta gtc tta ttt caa cag ata aca ggt 1104 Ala Phe Ile Ile Gly Gly Gly Leu Val Leu Phe Gln Gln Ile Thr Gly 355 360 365 caa cca agt gtt ctg tac tat gca ggt cca att ctt cag agt gct gga 1152 Gln Pro Ser Val Leu Tyr Tyr Ala Gly Pro Ile Leu Gln Ser Ala Gly 370 375 380 ttt tct gct gca tcc gat gct aca aaa gtt tcg gtt gtt att ggc cta 1200 Phe Ser Ala Ala Ser Asp Ala Thr Lys Val Ser Val Val Ile Gly Leu 385 390 395 400 ttc aag ttg cta atg act tgg att gct gtc cta aaa gtt gat gat ttg 1248 Phe Lys Leu Leu Met Thr Trp Ile Ala Val Leu Lys Val Asp Asp Leu 405 410 415 ggg aga aga cct ctg ctg att gga ggt gtc agt ggc att gcc ctt tct 1296 Gly Arg Arg Pro Leu Leu Ile Gly Gly Val Ser Gly Ile Ala Leu Ser 420 425 430 cta gtt ctc ctt tct gct tat tat aaa ttt ctt gga ggt ttc cca ctt 1344 Leu Val Leu Leu Ser Ala Tyr Tyr Lys Phe Leu Gly Gly Phe Pro Leu 435 440 445 gtt gct gtt gga gct tta ctt ctt tat gtt ggt tgc tac cag ata tca 1392 Val Ala Val Gly Ala Leu Leu Leu Tyr Val Gly Cys Tyr Gln Ile Ser 450 455 460 ttt ggg ccg ata agt tgg cta atg gta tca gag gtc ttc cca ctt cgc 1440 Phe Gly Pro Ile Ser Trp Leu Met Val Ser Glu Val Phe Pro Leu Arg 465 470 475 480 act aga gga aag ggg att agt ctg gct gtt ctt acc aac ttc gct tca 1488 Thr Arg Gly Lys Gly Ile Ser Leu Ala Val Leu Thr Asn Phe Ala Ser 485 490 495 aat gct gtt gtc acc ttt gca ttc tcc ccg cta aag gag ttt cta gga 1536 Asn Ala Val Val Thr Phe Ala Phe Ser Pro Leu Lys Glu Phe Leu Gly 500 505 510 gca gaa aat ctt ttt ctc ctt ttt ggg gct att gct att cta tca ctt 1584 Ala Glu Asn Leu Phe Leu Leu Phe Gly Ala Ile Ala Ile Leu Ser Leu 515 520 525 ttg ttc att atc ttt tct gtc cca gag aca aaa ggc ttg agt tta gaa 1632 Leu Phe Ile Ile Phe Ser Val Pro Glu Thr Lys Gly Leu Ser Leu Glu 530 535 540 gat ata gaa tcc aaa atc ttg aag tga 1659 Asp Ile Glu Ser Lys Ile Leu Lys 545 550 <210> 457 <211> 552 <212> PRT <213> Glycine max <400> 457 Met Ala Ser Thr Thr Leu Phe Ser Phe Arg Leu Ser Leu Asn Pro Leu 1 5 10 15 His His Gln Gln Thr Thr Arg Pro Lys Ser Leu Leu Ser Ser Pro Arg 20 25 30 Thr Asn Pro Arg Leu Val Ser Ser Ile Asn Asn His Leu Ala Leu Thr 35 40 45 Arg Val Thr Tyr Pro Leu Leu Gln Ser His Ser Ala Pro Lys Arg Arg 50 55 60 Phe His Val Tyr Ser Asp Gly Glu Ser Ser Glu Ser Leu Val Ser Asp 65 70 75 80 Page 547 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Thr Tyr Gln Glu Glu Phe Ser Trp Ser Ser Val Ile Leu Pro Phe 85 90 95 Leu Phe Pro Ala Leu Gly Gly Leu Leu Phe Gly Tyr Asp Ile Gly Ala 100 105 110 Thr Ser Gly Ala Thr Ile Ser Leu Gln Ser Pro Glu Leu Ser Gly Ile 115 120 125 Ser Trp Phe Lys Leu Ser Ala Ile Gln Leu Gly Leu Val Val Ser Gly 130 135 140 Ser Leu Tyr Gly Ala Leu Leu Gly Ser Leu Val Ala Phe Ala Ile Ala 145 150 155 160 Asp Phe Leu Gly Arg Lys Lys Gln Leu Ile Thr Ala Ala Leu Leu Tyr 165 170 175 Leu Phe Gly Gly Val Ile Thr Ala Tyr Ala Pro Glu Leu Gly Val Leu 180 185 190 Leu Ala Gly Arg Leu Leu Tyr Gly Leu Gly Ile Gly Leu Ala Met His 195 200 205 Gly Ala Pro Leu Tyr Ile Ala Glu Thr Cys Pro Ser Gln Ile Arg Gly 210 215 220 Thr Leu Val Ser Leu Lys Glu Leu Phe Ile Val Leu Gly Ile Leu Leu 225 230 235 240 Gly Tyr Phe Val Gly Ser Phe Leu Ile Glu Thr Val Gly Gly Trp Arg 245 250 255 Phe Met Tyr Gly Phe Ser Ala Pro Val Ala Val Leu Met Gly Leu Gly 260 265 270 Met Leu Thr Leu Pro Asn Ser Pro Arg Trp Leu Leu Leu Arg Ala Val 275 280 285 Gln Gly Lys Gly Ser Phe Gln Asp Leu Lys Glu Lys Ala Ile Phe Ser 290 295 300 Leu Ser Lys Leu Arg Gly Arg Pro Pro Gly Asp Lys Glu Ser Glu Arg 305 310 315 320 Gln Val Glu Glu Thr Leu Val Ser Leu Lys Ser Ala Tyr Ala Asp Lys 325 330 335 Glu Ser Glu Gly Asn Phe Leu Glu Val Phe Gln Gly Pro Asn Leu Lys 340 345 350 Ala Phe Ile Ile Gly Gly Gly Leu Val Leu Phe Gln Gln Ile Thr Gly 355 360 365 Gln Pro Ser Val Leu Tyr Tyr Ala Gly Pro Ile Leu Gln Ser Ala Gly 370 375 380 Phe Ser Ala Ala Ser Asp Ala Thr Lys Val Ser Val Val Ile Gly Leu 385 390 395 400 Phe Lys Leu Leu Met Thr Trp Ile Ala Val Leu Lys Val Asp Asp Leu 405 410 415 Gly Arg Arg Pro Leu Leu Ile Gly Gly Val Ser Gly Ile Ala Leu Ser 420 425 430 Leu Val Leu Leu Ser Ala Tyr Tyr Lys Phe Leu Gly Gly Phe Pro Leu 435 440 445 Val Ala Val Gly Ala Leu Leu Leu Tyr Val Gly Cys Tyr Gln Ile Ser 450 455 460 Phe Gly Pro Ile Ser Trp Leu Met Val Ser Glu Val Phe Pro Leu Arg 465 470 475 480 Thr Arg Gly Lys Gly Ile Ser Leu Ala Val Leu Thr Asn Phe Ala Ser 485 490 495 Asn Ala Val Val Thr Phe Ala Phe Ser Pro Leu Lys Glu Phe Leu Gly 500 505 510 Ala Glu Asn Leu Phe Leu Leu Phe Gly Ala Ile Ala Ile Leu Ser Leu 515 520 525 Leu Phe Ile Ile Phe Ser Val Pro Glu Thr Lys Gly Leu Ser Leu Glu 530 535 540 Asp Ile Glu Ser Lys Ile Leu Lys 545 550 <210> 458 <211> 1452 <212> DNA <213> Glycine max <220> <221> CDS Page 548 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <222> (1)..(1452) <400> 458 atg tgg gtg gga cat tca tct atg tac aag cgc act cct tcg aga gat 48 Met Trp Val Gly His Ser Ser Met Tyr Lys Arg Thr Pro Ser Arg Asp 1 5 10 15 aat tca aac atg gag gac atg gaa gaa aac tca gac atc ggc ctg gac 96 Asn Ser Asn Met Glu Asp Met Glu Glu Asn Ser Asp Ile Gly Leu Asp 20 25 30 aag gga aca tca aat cct tca ttg atg ctt tct tta ccg cat gta ctt 144 Lys Gly Thr Ser Asn Pro Ser Leu Met Leu Ser Leu Pro His Val Leu 35 40 45 gtg gcg acc att tct tca ttc ctt ttt gga tac cat ctg ggg gtt gtt 192 Val Ala Thr Ile Ser Ser Phe Leu Phe Gly Tyr His Leu Gly Val Val 50 55 60 aat gaa cca ctt gag agc att tct gtg gat ctt ggc ttc cgt gga aat 240 Asn Glu Pro Leu Glu Ser Ile Ser Val Asp Leu Gly Phe Arg Gly Asn 65 70 75 80 aca ttg gca gaa ggt ctg gtg gtg agc ata tgc ctt ggt ggt gcc ttg 288 Thr Leu Ala Glu Gly Leu Val Val Ser Ile Cys Leu Gly Gly Ala Leu 85 90 95 att gga tgt cta cta agt ggt tgg att gct gat ggg gtg ggg cgt cgt 336 Ile Gly Cys Leu Leu Ser Gly Trp Ile Ala Asp Gly Val Gly Arg Arg 100 105 110 agg gct ttc cag ttg tgt gct ctg cca atg ata att ggt gct tct atg 384 Arg Ala Phe Gln Leu Cys Ala Leu Pro Met Ile Ile Gly Ala Ser Met 115 120 125 agt gca gca aca aac aac ttg ttt ggc atg ctt gta gga agg ttg ttt 432 Ser Ala Ala Thr Asn Asn Leu Phe Gly Met Leu Val Gly Arg Leu Phe 130 135 140 gtt ggg act ggc ttg ggc ctg ggc cct cct gtt gcc tct ctg tat gtg 480 Val Gly Thr Gly Leu Gly Leu Gly Pro Pro Val Ala Ser Leu Tyr Val 145 150 155 160 aca gag gtt tct cct gct ttt gtg cgg ggc acc ttt gga gct ttc atc 528 Thr Glu Val Ser Pro Ala Phe Val Arg Gly Thr Phe Gly Ala Phe Ile 165 170 175 cag att gca aca tgc ctt ggt cta atg gga gct tta ttt att gga atc 576 Gln Ile Ala Thr Cys Leu Gly Leu Met Gly Ala Leu Phe Ile Gly Ile 180 185 190 cct gtc aaa gaa att tct gga tgg tgg cgg gtt tgt ttt tgg gta tct 624 Pro Val Lys Glu Ile Ser Gly Trp Trp Arg Val Cys Phe Trp Val Ser 195 200 205 acc att cca gct gct ata ctt gcc gca gct atg gtc ttc tgc gca gag 672 Thr Ile Pro Ala Ala Ile Leu Ala Ala Ala Met Val Phe Cys Ala Glu 210 215 220 agt ccg cat tgg tta tac aag caa gga aga act gct gaa gca gaa gct 720 Ser Pro His Trp Leu Tyr Lys Gln Gly Arg Thr Ala Glu Ala Glu Ala 225 230 235 240 gag ttt gag aga ctt ctg ggt gta tca gaa gca aaa ttt gca atg tcg 768 Glu Phe Glu Arg Leu Leu Gly Val Ser Glu Ala Lys Phe Ala Met Ser 245 250 255 gag tta tcc aag gta gat aga agt gat gat act gat act gta aag ctg 816 Glu Leu Ser Lys Val Asp Arg Ser Asp Asp Thr Asp Thr Val Lys Leu 260 265 270 tcg gaa ttg ctt cat ggt cgt cat tct aaa gtt gtt ttt att gga tca 864 Ser Glu Leu Leu His Gly Arg His Ser Lys Val Val Phe Ile Gly Ser 275 280 285 acc cta ttt gct tta caa cag cta tct ggt ata aat gct ggg ttt tat 912 Thr Leu Phe Ala Leu Gln Gln Leu Ser Gly Ile Asn Ala Gly Phe Tyr 290 295 300 ttc tct tca act gtt ttt aaa agt gct gga gtc cca tca gac att gca 960 Phe Ser Ser Thr Val Phe Lys Ser Ala Gly Val Pro Ser Asp Ile Ala 305 310 315 320 aat gtc tgc ata gga atc gct aat ttg gca gga tct atc gtt tca atg 1008 Asn Val Cys Ile Gly Ile Ala Asn Leu Ala Gly Ser Ile Val Ser Met 325 330 335 ggt ttg atg gat aag ctt gga agg aag gtt cta ctt ttc tgg agt ttc 1056 Gly Leu Met Asp Lys Leu Gly Arg Lys Val Leu Leu Phe Trp Ser Phe Page 549 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 340 345 350 ttt ggc atg gca ata gca atg atc ctt caa gcc aca gga gca act tca 1104 Phe Gly Met Ala Ile Ala Met Ile Leu Gln Ala Thr Gly Ala Thr Ser 355 360 365 ctt gta tca aac gtg gga gct cag tac ttt tct gtt ggt ggc atg tta 1152 Leu Val Ser Asn Val Gly Ala Gln Tyr Phe Ser Val Gly Gly Met Leu 370 375 380 ctg ttt gtc tta aca ttt gct ctg ggg gct ggt cca gtt cca ggt ctc 1200 Leu Phe Val Leu Thr Phe Ala Leu Gly Ala Gly Pro Val Pro Gly Leu 385 390 395 400 ctt cta cca gaa atc ttt cct agt cga ata aga gcc aaa gcc atg gca 1248 Leu Leu Pro Glu Ile Phe Pro Ser Arg Ile Arg Ala Lys Ala Met Ala 405 410 415 gtc tgt atg tca gtg cat tgg gtg ata aat ttc ttt gtt gga cta ctg 1296 Val Cys Met Ser Val His Trp Val Ile Asn Phe Phe Val Gly Leu Leu 420 425 430 ttc ttg cgt ttg ctg gag aaa ctt ggt cca cag ctg ctt tac tcc atg 1344 Phe Leu Arg Leu Leu Glu Lys Leu Gly Pro Gln Leu Leu Tyr Ser Met 435 440 445 ttt gct acc ttt tgc atc atg gca gta act ttt gta aaa aga aat gtg 1392 Phe Ala Thr Phe Cys Ile Met Ala Val Thr Phe Val Lys Arg Asn Val 450 455 460 gtg gaa acc aaa ggg aag tca ctt cat gaa att gag atc gca ctt ctt 1440 Val Glu Thr Lys Gly Lys Ser Leu His Glu Ile Glu Ile Ala Leu Leu 465 470 475 480 cct caa gac tag 1452 Pro Gln Asp <210> 459 <211> 483 <212> PRT <213> Glycine max <400> 459 Met Trp Val Gly His Ser Ser Met Tyr Lys Arg Thr Pro Ser Arg Asp 1 5 10 15 Asn Ser Asn Met Glu Asp Met Glu Glu Asn Ser Asp Ile Gly Leu Asp 20 25 30 Lys Gly Thr Ser Asn Pro Ser Leu Met Leu Ser Leu Pro His Val Leu 35 40 45 Val Ala Thr Ile Ser Ser Phe Leu Phe Gly Tyr His Leu Gly Val Val 50 55 60 Asn Glu Pro Leu Glu Ser Ile Ser Val Asp Leu Gly Phe Arg Gly Asn 65 70 75 80 Thr Leu Ala Glu Gly Leu Val Val Ser Ile Cys Leu Gly Gly Ala Leu 85 90 95 Ile Gly Cys Leu Leu Ser Gly Trp Ile Ala Asp Gly Val Gly Arg Arg 100 105 110 Arg Ala Phe Gln Leu Cys Ala Leu Pro Met Ile Ile Gly Ala Ser Met 115 120 125 Ser Ala Ala Thr Asn Asn Leu Phe Gly Met Leu Val Gly Arg Leu Phe 130 135 140 Val Gly Thr Gly Leu Gly Leu Gly Pro Pro Val Ala Ser Leu Tyr Val 145 150 155 160 Thr Glu Val Ser Pro Ala Phe Val Arg Gly Thr Phe Gly Ala Phe Ile 165 170 175 Gln Ile Ala Thr Cys Leu Gly Leu Met Gly Ala Leu Phe Ile Gly Ile 180 185 190 Pro Val Lys Glu Ile Ser Gly Trp Trp Arg Val Cys Phe Trp Val Ser 195 200 205 Thr Ile Pro Ala Ala Ile Leu Ala Ala Ala Met Val Phe Cys Ala Glu 210 215 220 Ser Pro His Trp Leu Tyr Lys Gln Gly Arg Thr Ala Glu Ala Glu Ala 225 230 235 240 Glu Phe Glu Arg Leu Leu Gly Val Ser Glu Ala Lys Phe Ala Met Ser 245 250 255 Glu Leu Ser Lys Val Asp Arg Ser Asp Asp Thr Asp Thr Val Lys Leu Page 550 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 260 265 270 Ser Glu Leu Leu His Gly Arg His Ser Lys Val Val Phe Ile Gly Ser 275 280 285 Thr Leu Phe Ala Leu Gln Gln Leu Ser Gly Ile Asn Ala Gly Phe Tyr 290 295 300 Phe Ser Ser Thr Val Phe Lys Ser Ala Gly Val Pro Ser Asp Ile Ala 305 310 315 320 Asn Val Cys Ile Gly Ile Ala Asn Leu Ala Gly Ser Ile Val Ser Met 325 330 335 Gly Leu Met Asp Lys Leu Gly Arg Lys Val Leu Leu Phe Trp Ser Phe 340 345 350 Phe Gly Met Ala Ile Ala Met Ile Leu Gln Ala Thr Gly Ala Thr Ser 355 360 365 Leu Val Ser Asn Val Gly Ala Gln Tyr Phe Ser Val Gly Gly Met Leu 370 375 380 Leu Phe Val Leu Thr Phe Ala Leu Gly Ala Gly Pro Val Pro Gly Leu 385 390 395 400 Leu Leu Pro Glu Ile Phe Pro Ser Arg Ile Arg Ala Lys Ala Met Ala 405 410 415 Val Cys Met Ser Val His Trp Val Ile Asn Phe Phe Val Gly Leu Leu 420 425 430 Phe Leu Arg Leu Leu Glu Lys Leu Gly Pro Gln Leu Leu Tyr Ser Met 435 440 445 Phe Ala Thr Phe Cys Ile Met Ala Val Thr Phe Val Lys Arg Asn Val 450 455 460 Val Glu Thr Lys Gly Lys Ser Leu His Glu Ile Glu Ile Ala Leu Leu 465 470 475 480 Pro Gln Asp <210> 460 <211> 1080 <212> DNA <213> Glycine max <220> <221> CDS <222> (1)..(1080) <400> 460 atg gca gca caa gct gaa att gag cat cct agg aaa gca ttc gga tgg 48 Met Ala Ala Gln Ala Glu Ile Glu His Pro Arg Lys Ala Phe Gly Trp 1 5 10 15 gca gct agg gat tct tcc ggt ctt ctc tcc cct ttc aat ttc tgc aga 96 Ala Ala Arg Asp Ser Ser Gly Leu Leu Ser Pro Phe Asn Phe Cys Arg 20 25 30 agg gaa ccc ggt gag aaa gat gtg gca ttc aga gtg ttg tac tgt ggg 144 Arg Glu Pro Gly Glu Lys Asp Val Ala Phe Arg Val Leu Tyr Cys Gly 35 40 45 ata tgc cac tcg gac ctc cac agc ata aag aac gaa tgg ggt act tcc 192 Ile Cys His Ser Asp Leu His Ser Ile Lys Asn Glu Trp Gly Thr Ser 50 55 60 atc tat cca atg gtt cct ggg cat gag gta gct ggt gta gta aca gag 240 Ile Tyr Pro Met Val Pro Gly His Glu Val Ala Gly Val Val Thr Glu 65 70 75 80 gtg gga agc aaa gta gag aag ttc aaa gtt ggg gac aag gtt ggt gtg 288 Val Gly Ser Lys Val Glu Lys Phe Lys Val Gly Asp Lys Val Gly Val 85 90 95 gga tgc ctg gtt gat tcc tgc cgc acc tgc caa aac tgt tgc gac aat 336 Gly Cys Leu Val Asp Ser Cys Arg Thr Cys Gln Asn Cys Cys Asp Asn 100 105 110 ctt gag aat tat tgt cct caa tct acg ttc aca tat ggt gcc aaa tat 384 Leu Glu Asn Tyr Cys Pro Gln Ser Thr Phe Thr Tyr Gly Ala Lys Tyr 115 120 125 aga gat gga acc atc aca tat gga ggc tac tct gac tca atg gtt gct 432 Arg Asp Gly Thr Ile Thr Tyr Gly Gly Tyr Ser Asp Ser Met Val Ala 130 135 140 gat gag cat ttt gtg gtt cgc att cca gat aga tta cca ctt gat gct 480 Page 551 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Asp Glu His Phe Val Val Arg Ile Pro Asp Arg Leu Pro Leu Asp Ala 145 150 155 160 gct gca cct ctt ctt tgt gct ggc atc act gtg tat agc cct ctc aga 528 Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Ser Pro Leu Arg 165 170 175 tat tat gga ctt gac aag cct ggt ctg cat gtg ggt gtg gtt ggt ctt 576 Tyr Tyr Gly Leu Asp Lys Pro Gly Leu His Val Gly Val Val Gly Leu 180 185 190 ggt gga cta ggc cat atg gct gtc aag ttt gcc aaa gct ttt ggt gct 624 Gly Gly Leu Gly His Met Ala Val Lys Phe Ala Lys Ala Phe Gly Ala 195 200 205 aag gtc aca gta ata agt act tca cca aac aaa aag gaa gaa gca ata 672 Lys Val Thr Val Ile Ser Thr Ser Pro Asn Lys Lys Glu Glu Ala Ile 210 215 220 caa aat ctt gga gct gat tct ttt cta ata agc cgg gac caa gat cag 720 Gln Asn Leu Gly Ala Asp Ser Phe Leu Ile Ser Arg Asp Gln Asp Gln 225 230 235 240 atg cag gct gca atg ggt act ttg gat ggt att att gac aca gtt tct 768 Met Gln Ala Ala Met Gly Thr Leu Asp Gly Ile Ile Asp Thr Val Ser 245 250 255 gcc gtt cat cct ctc tta cct ctc att ggt ttg ctc aag tct cat gga 816 Ala Val His Pro Leu Leu Pro Leu Ile Gly Leu Leu Lys Ser His Gly 260 265 270 aag ctt gta atg gtt ggt gca ccg gag aag cct ctg gaa ctg cct gtt 864 Lys Leu Val Met Val Gly Ala Pro Glu Lys Pro Leu Glu Leu Pro Val 275 280 285 ttt cct tta ctt gcg ggg aga aag ata gtt gct ggc act ctg att gga 912 Phe Pro Leu Leu Ala Gly Arg Lys Ile Val Ala Gly Thr Leu Ile Gly 290 295 300 ggg cta atg gag acg caa gaa atg att gat ttt gca gcg aaa cac aat 960 Gly Leu Met Glu Thr Gln Glu Met Ile Asp Phe Ala Ala Lys His Asn 305 310 315 320 gtg aaa cct gac att gaa gtc att cct atg gac tat gtc aac aca gca 1008 Val Lys Pro Asp Ile Glu Val Ile Pro Met Asp Tyr Val Asn Thr Ala 325 330 335 atg gag cgc ctc ctt aaa gca gat gtt aaa tat cga ttt gtt att gat 1056 Met Glu Arg Leu Leu Lys Ala Asp Val Lys Tyr Arg Phe Val Ile Asp 340 345 350 att gga aac aca ctg aaa ttc tga 1080 Ile Gly Asn Thr Leu Lys Phe 355 <210> 461 <211> 359 <212> PRT <213> Glycine max <400> 461 Met Ala Ala Gln Ala Glu Ile Glu His Pro Arg Lys Ala Phe Gly Trp 1 5 10 15 Ala Ala Arg Asp Ser Ser Gly Leu Leu Ser Pro Phe Asn Phe Cys Arg 20 25 30 Arg Glu Pro Gly Glu Lys Asp Val Ala Phe Arg Val Leu Tyr Cys Gly 35 40 45 Ile Cys His Ser Asp Leu His Ser Ile Lys Asn Glu Trp Gly Thr Ser 50 55 60 Ile Tyr Pro Met Val Pro Gly His Glu Val Ala Gly Val Val Thr Glu 65 70 75 80 Val Gly Ser Lys Val Glu Lys Phe Lys Val Gly Asp Lys Val Gly Val 85 90 95 Gly Cys Leu Val Asp Ser Cys Arg Thr Cys Gln Asn Cys Cys Asp Asn 100 105 110 Leu Glu Asn Tyr Cys Pro Gln Ser Thr Phe Thr Tyr Gly Ala Lys Tyr 115 120 125 Arg Asp Gly Thr Ile Thr Tyr Gly Gly Tyr Ser Asp Ser Met Val Ala 130 135 140 Asp Glu His Phe Val Val Arg Ile Pro Asp Arg Leu Pro Leu Asp Ala 145 150 155 160 Page 552 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Ser Pro Leu Arg 165 170 175 Tyr Tyr Gly Leu Asp Lys Pro Gly Leu His Val Gly Val Val Gly Leu 180 185 190 Gly Gly Leu Gly His Met Ala Val Lys Phe Ala Lys Ala Phe Gly Ala 195 200 205 Lys Val Thr Val Ile Ser Thr Ser Pro Asn Lys Lys Glu Glu Ala Ile 210 215 220 Gln Asn Leu Gly Ala Asp Ser Phe Leu Ile Ser Arg Asp Gln Asp Gln 225 230 235 240 Met Gln Ala Ala Met Gly Thr Leu Asp Gly Ile Ile Asp Thr Val Ser 245 250 255 Ala Val His Pro Leu Leu Pro Leu Ile Gly Leu Leu Lys Ser His Gly 260 265 270 Lys Leu Val Met Val Gly Ala Pro Glu Lys Pro Leu Glu Leu Pro Val 275 280 285 Phe Pro Leu Leu Ala Gly Arg Lys Ile Val Ala Gly Thr Leu Ile Gly 290 295 300 Gly Leu Met Glu Thr Gln Glu Met Ile Asp Phe Ala Ala Lys His Asn 305 310 315 320 Val Lys Pro Asp Ile Glu Val Ile Pro Met Asp Tyr Val Asn Thr Ala 325 330 335 Met Glu Arg Leu Leu Lys Ala Asp Val Lys Tyr Arg Phe Val Ile Asp 340 345 350 Ile Gly Asn Thr Leu Lys Phe 355 <210> 462 <211> 645 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(645) <400> 462 atg agc ggc gcc acc aag ttc atc aag tgc gtc acc gtc ggc gac ggc 48 Met Ser Gly Ala Thr Lys Phe Ile Lys Cys Val Thr Val Gly Asp Gly 1 5 10 15 gcc gtc ggc aag acc tgc atg ctc atc tgc tac atc agc aac aag ttc 96 Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Ile Ser Asn Lys Phe 20 25 30 ccc acc gat tac atc ccc acc gtg ttc gac aac ttc agt gct aat gtt 144 Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val 35 40 45 tca gtg gat ggg aac atc gtc aac ttg gga tta tgg gac act gct gga 192 Ser Val Asp Gly Asn Ile Val Asn Leu Gly Leu Trp Asp Thr Ala Gly 50 55 60 caa gag gat tac agc agg ctg agg cca ctg agc tac agg gga gcg gat 240 Gln Glu Asp Tyr Ser Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp 65 70 75 80 ata ttt gtg ctg gca ttc tca ctg atc agc aga gca agc tat gag aat 288 Ile Phe Val Leu Ala Phe Ser Leu Ile Ser Arg Ala Ser Tyr Glu Asn 85 90 95 gtt ctc aag aag tgg atg ccg gag ctt cgc cgg ttc gca ccg aat gtt 336 Val Leu Lys Lys Trp Met Pro Glu Leu Arg Arg Phe Ala Pro Asn Val 100 105 110 cca att gtt ctt gtt ggg acc aag tta gat cta cgt gac cac aga tct 384 Pro Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp His Arg Ser 115 120 125 tac ctt gcg gac cat cct gct gct tcc gca att acg act gca cag ggt 432 Tyr Leu Ala Asp His Pro Ala Ala Ser Ala Ile Thr Thr Ala Gln Gly 130 135 140 gaa gaa ctt aga aag cag ata ggc gcc gcg gct tac atc gaa tgc agt 480 Glu Glu Leu Arg Lys Gln Ile Gly Ala Ala Ala Tyr Ile Glu Cys Ser 145 150 155 160 tcg aaa aca caa cag aac atc aag gcc gtg ttt gat act gcc atc aag 528 Page 553 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Lys Thr Gln Gln Asn Ile Lys Ala Val Phe Asp Thr Ala Ile Lys 165 170 175 gtg gtc ctt cag cct cct cgg aga agg ggg gag acg acg atg gca agg 576 Val Val Leu Gln Pro Pro Arg Arg Arg Gly Glu Thr Thr Met Ala Arg 180 185 190 aag aag aca agg cga agc acc ggc tgc tcg tta aag aac ttg atg tgt 624 Lys Lys Thr Arg Arg Ser Thr Gly Cys Ser Leu Lys Asn Leu Met Cys 195 200 205 ggc agt gca tgt gtt gtt tag 645 Gly Ser Ala Cys Val Val 210 <210> 463 <211> 214 <212> PRT <213> Oryza sativa <400> 463 Met Ser Gly Ala Thr Lys Phe Ile Lys Cys Val Thr Val Gly Asp Gly 1 5 10 15 Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Ile Ser Asn Lys Phe 20 25 30 Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser Ala Asn Val 35 40 45 Ser Val Asp Gly Asn Ile Val Asn Leu Gly Leu Trp Asp Thr Ala Gly 50 55 60 Gln Glu Asp Tyr Ser Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala Asp 65 70 75 80 Ile Phe Val Leu Ala Phe Ser Leu Ile Ser Arg Ala Ser Tyr Glu Asn 85 90 95 Val Leu Lys Lys Trp Met Pro Glu Leu Arg Arg Phe Ala Pro Asn Val 100 105 110 Pro Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Asp His Arg Ser 115 120 125 Tyr Leu Ala Asp His Pro Ala Ala Ser Ala Ile Thr Thr Ala Gln Gly 130 135 140 Glu Glu Leu Arg Lys Gln Ile Gly Ala Ala Ala Tyr Ile Glu Cys Ser 145 150 155 160 Ser Lys Thr Gln Gln Asn Ile Lys Ala Val Phe Asp Thr Ala Ile Lys 165 170 175 Val Val Leu Gln Pro Pro Arg Arg Arg Gly Glu Thr Thr Met Ala Arg 180 185 190 Lys Lys Thr Arg Arg Ser Thr Gly Cys Ser Leu Lys Asn Leu Met Cys 195 200 205 Gly Ser Ala Cys Val Val 210 <210> 464 <211> 786 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(786) <400> 464 atg gcc gtg ggc aag aac aag agg atc tcc aag ggc agg aag ggc agc 48 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Ser 1 5 10 15 aag aag aag acc gtc gat ccc ttt tcc aag aag gat tgg tac gac atc 96 Lys Lys Lys Thr Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 aag gcg ccg acc gtg ttc tcc gtc cgc aac atc ggc aag acc ctc gtc 144 Lys Ala Pro Thr Val Phe Ser Val Arg Asn Ile Gly Lys Thr Leu Val 35 40 45 tcc agg acc cag ggg acc aag att gca tct gag ggt ctc aag cat cgt 192 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg Page 554 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 50 55 60 gtc ttt gaa gtc tcc ttg gcg gat ctt cag aat gac gag gat cag gct 240 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Asp Gln Ala 65 70 75 80 tac agg aag gtt aga ctt cgt gct gag gat gtt cag ggg agg aat gtc 288 Tyr Arg Lys Val Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 ctc acg aat ttc tgg ggc atg agt ttt acc acg gac aaa ctt agg tcc 336 Leu Thr Asn Phe Trp Gly Met Ser Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 ttg gtc aag aaa tgg caa aca ttg att gaa gcc cat gtg gat gtt aag 384 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 acc aca gat aac tac atg ctc cgc ctg ttt tgc att ggt ttc acc aag 432 Thr Thr Asp Asn Tyr Met Leu Arg Leu Phe Cys Ile Gly Phe Thr Lys 130 135 140 cgc cgc cca aat cag gtg aag cgt acc tgt tac gct cag gct agc cag 480 Arg Arg Pro Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ala Ser Gln 145 150 155 160 atc cgg cag atc cgc cgg aag atg gtt gag atc atg gcc aac cag gca 528 Ile Arg Gln Ile Arg Arg Lys Met Val Glu Ile Met Ala Asn Gln Ala 165 170 175 tca aca tgt gac ttg aaa gaa ctg gtt tca aaa ttc atc cct gaa gtc 576 Ser Thr Cys Asp Leu Lys Glu Leu Val Ser Lys Phe Ile Pro Glu Val 180 185 190 att gga aag gag atc gag aag tca act tca agt ata ttc cct ctc caa 624 Ile Gly Lys Glu Ile Glu Lys Ser Thr Ser Ser Ile Phe Pro Leu Gln 195 200 205 aat gtg ttc atc cgc aag gtg aag atc ttg aag gca ccg aag ttt gat 672 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 ctt ggg aag ttg atg gag gta cac ggt gac tac aag gaa gat gtc ggt 720 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Lys Glu Asp Val Gly 225 230 235 240 atg aag ctg gac agg cct gct gag act gac gag gcg gtg gca ggg gag 768 Met Lys Leu Asp Arg Pro Ala Glu Thr Asp Glu Ala Val Ala Gly Glu 245 250 255 gtt gca gca gct gag tag 786 Val Ala Ala Ala Glu 260 <210> 465 <211> 261 <212> PRT <213> Oryza sativa <400> 465 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Arg Lys Gly Ser 1 5 10 15 Lys Lys Lys Thr Val Asp Pro Phe Ser Lys Lys Asp Trp Tyr Asp Ile 20 25 30 Lys Ala Pro Thr Val Phe Ser Val Arg Asn Ile Gly Lys Thr Leu Val 35 40 45 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Asp Gln Ala 65 70 75 80 Tyr Arg Lys Val Arg Leu Arg Ala Glu Asp Val Gln Gly Arg Asn Val 85 90 95 Leu Thr Asn Phe Trp Gly Met Ser Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 Thr Thr Asp Asn Tyr Met Leu Arg Leu Phe Cys Ile Gly Phe Thr Lys 130 135 140 Arg Arg Pro Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ala Ser Gln 145 150 155 160 Ile Arg Gln Ile Arg Arg Lys Met Val Glu Ile Met Ala Asn Gln Ala Page 555 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 165 170 175 Ser Thr Cys Asp Leu Lys Glu Leu Val Ser Lys Phe Ile Pro Glu Val 180 185 190 Ile Gly Lys Glu Ile Glu Lys Ser Thr Ser Ser Ile Phe Pro Leu Gln 195 200 205 Asn Val Phe Ile Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Lys Glu Asp Val Gly 225 230 235 240 Met Lys Leu Asp Arg Pro Ala Glu Thr Asp Glu Ala Val Ala Gly Glu 245 250 255 Val Ala Ala Ala Glu 260 <210> 466 <211> 411 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(411) <400> 466 atg gct cgt act aag caa act gct cgc aag tca act gga gga aag gct 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccc agg aag caa ctt gcc acc aag gct gct cgt aag tct gct ccc aca 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 act gga gga gtg aag aag cct cac cgt tac cgc cct gga act gtt gct 144 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 ctt cgt gaa atc cgc aag tac cag aag agc act gag ctg ctc ata agg 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctt cca ttc cag agg ctt gtt agg gag att gcc cag gat ttt aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 act gat ctt cgt ttc cag agc cat gcg gtg ctt gcc ctt cag gaa gct 288 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 gcc gag gcg tac ctg gtg ggt ctc ttc gag gac acc aac ctg tgc gcc 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 atc cat gcc aag cgt gtg acc atc atg ccc aag gac att cag ctg gct 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 agg agg atc cgt ggt gag agg gct tag 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 467 <211> 136 <212> PRT <213> Oryza sativa <400> 467 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Page 556 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 468 <211> 741 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(741) <400> 468 atg gac gcc tct ctc atg ggc gcc ccc tcc gcc gca gcg gga gac aat 48 Met Asp Ala Ser Leu Met Gly Ala Pro Ser Ala Ala Ala Gly Asp Asn 1 5 10 15 ccc acc tcc ggg gag cac cgg atg ggg acc acc atc gtc ggc gtc tgc 96 Pro Thr Ser Gly Glu His Arg Met Gly Thr Thr Ile Val Gly Val Cys 20 25 30 tac gac ggc ggc gtc gtc ctc gcc gcc gat tcc aga acc agc acc gga 144 Tyr Asp Gly Gly Val Val Leu Ala Ala Asp Ser Arg Thr Ser Thr Gly 35 40 45 atg tat gtg gca aac cgt gcg tcg gac aag att act cag cta act gac 192 Met Tyr Val Ala Asn Arg Ala Ser Asp Lys Ile Thr Gln Leu Thr Asp 50 55 60 aat gtg tac atc tgc cgc tct gga tct gct gct gat aca caa gta att 240 Asn Val Tyr Ile Cys Arg Ser Gly Ser Ala Ala Asp Thr Gln Val Ile 65 70 75 80 tcc gat tat gta cgc tat ttt ctc cac caa cac aca att cag ctt ggg 288 Ser Asp Tyr Val Arg Tyr Phe Leu His Gln His Thr Ile Gln Leu Gly 85 90 95 cag cca gct acc gtg aaa gtt gca gcc aac tta att agg ttg ttg gct 336 Gln Pro Ala Thr Val Lys Val Ala Ala Asn Leu Ile Arg Leu Leu Ala 100 105 110 tat cag aac aag aac atg ttg caa gct ggc atg att gtt ggt gga tgg 384 Tyr Gln Asn Lys Asn Met Leu Gln Ala Gly Met Ile Val Gly Gly Trp 115 120 125 gat aaa tat gag gga ggc caa att ttc tca gtc ccc ctt ggt gga aca 432 Asp Lys Tyr Glu Gly Gly Gln Ile Phe Ser Val Pro Leu Gly Gly Thr 130 135 140 att ctg agg caa cca ttt gca atc gga ggt tca ggc tct agt tac ctc 480 Ile Leu Arg Gln Pro Phe Ala Ile Gly Gly Ser Gly Ser Ser Tyr Leu 145 150 155 160 tat gga ttg ctt gac cac gaa tgg aag gag ggc atg tcc cag gaa gaa 528 Tyr Gly Leu Leu Asp His Glu Trp Lys Glu Gly Met Ser Gln Glu Glu 165 170 175 gct gag aag ttt gtg gtt aag gta gtt tcc ctt gct ata gcc cgt gat 576 Ala Glu Lys Phe Val Val Lys Val Val Ser Leu Ala Ile Ala Arg Asp 180 185 190 ggt gct agt gga ggg gtt gtt cgt acc gtc act ata aac gca gat ggt 624 Gly Ala Ser Gly Gly Val Val Arg Thr Val Thr Ile Asn Ala Asp Gly 195 200 205 gtt tcg agg aaa ttt cac cct gga gac aaa cta caa ctg tgg cat gaa 672 Val Ser Arg Lys Phe His Pro Gly Asp Lys Leu Gln Leu Trp His Glu 210 215 220 gag ctg gag ccc cag aac tcg ttg ctg gac ata ctt gca gct ggg aac 720 Glu Leu Glu Pro Gln Asn Ser Leu Leu Asp Ile Leu Ala Ala Gly Asn 225 230 235 240 cct gat ccg atg gtc caa tga 741 Pro Asp Pro Met Val Gln 245 Page 557 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 469 <211> 246 <212> PRT <213> Oryza sativa <400> 469 Met Asp Ala Ser Leu Met Gly Ala Pro Ser Ala Ala Ala Gly Asp Asn 1 5 10 15 Pro Thr Ser Gly Glu His Arg Met Gly Thr Thr Ile Val Gly Val Cys 20 25 30 Tyr Asp Gly Gly Val Val Leu Ala Ala Asp Ser Arg Thr Ser Thr Gly 35 40 45 Met Tyr Val Ala Asn Arg Ala Ser Asp Lys Ile Thr Gln Leu Thr Asp 50 55 60 Asn Val Tyr Ile Cys Arg Ser Gly Ser Ala Ala Asp Thr Gln Val Ile 65 70 75 80 Ser Asp Tyr Val Arg Tyr Phe Leu His Gln His Thr Ile Gln Leu Gly 85 90 95 Gln Pro Ala Thr Val Lys Val Ala Ala Asn Leu Ile Arg Leu Leu Ala 100 105 110 Tyr Gln Asn Lys Asn Met Leu Gln Ala Gly Met Ile Val Gly Gly Trp 115 120 125 Asp Lys Tyr Glu Gly Gly Gln Ile Phe Ser Val Pro Leu Gly Gly Thr 130 135 140 Ile Leu Arg Gln Pro Phe Ala Ile Gly Gly Ser Gly Ser Ser Tyr Leu 145 150 155 160 Tyr Gly Leu Leu Asp His Glu Trp Lys Glu Gly Met Ser Gln Glu Glu 165 170 175 Ala Glu Lys Phe Val Val Lys Val Val Ser Leu Ala Ile Ala Arg Asp 180 185 190 Gly Ala Ser Gly Gly Val Val Arg Thr Val Thr Ile Asn Ala Asp Gly 195 200 205 Val Ser Arg Lys Phe His Pro Gly Asp Lys Leu Gln Leu Trp His Glu 210 215 220 Glu Leu Glu Pro Gln Asn Ser Leu Leu Asp Ile Leu Ala Ala Gly Asn 225 230 235 240 Pro Asp Pro Met Val Gln 245 <210> 470 <211> 543 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(543) <400> 470 atg gga ttc atc ggc gat acg gtg gag tcg atc cgc tcg ata cag atc 48 Met Gly Phe Ile Gly Asp Thr Val Glu Ser Ile Arg Ser Ile Gln Ile 1 5 10 15 cgc caa gtc ctc gcg caa atc atc agc ctc ggt atg att gtt acc tcg 96 Arg Gln Val Leu Ala Gln Ile Ile Ser Leu Gly Met Ile Val Thr Ser 20 25 30 gca ctg atc ata tgg aag gga ttg atg gtt gca acg ggg agc gag tcc 144 Ala Leu Ile Ile Trp Lys Gly Leu Met Val Ala Thr Gly Ser Glu Ser 35 40 45 cca gtg gtt gtg gtc ctt tct ggt agc atg gag cct gga ttt aaa agg 192 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 ggc gat atc ctt ttt cta cac atg agc aaa gat cct atc cgc aca gga 240 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Thr Gly 65 70 75 80 gag ata gtt gtt ttc aac att gat ggc cgt gaa att cca att gtt cac 288 Glu Ile Val Val Phe Asn Ile Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 cgt gtg att aag gtc cat gaa cgc gag gaa agt gct gaa gtt gat atc 336 Page 558 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg Val Ile Lys Val His Glu Arg Glu Glu Ser Ala Glu Val Asp Ile 100 105 110 ctc acg aaa ggt gat aat aat ttt ggg gac gac cgt ctt ctt tat gca 384 Leu Thr Lys Gly Asp Asn Asn Phe Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 cat ggg cag ctt tgg ctt cac caa cat cac att atg gga cgg gct gta 432 His Gly Gln Leu Trp Leu His Gln His His Ile Met Gly Arg Ala Val 130 135 140 ggc ttt ctt cca tat gtc ggg tgg gtt aca atc atc atg act gag aaa 480 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 cca ttt ata aag tac ctg ctc atc ggc gct ctg ggc ttg ctg gtc att 528 Pro Phe Ile Lys Tyr Leu Leu Ile Gly Ala Leu Gly Leu Leu Val Ile 165 170 175 aca tcg aaa gag taa 543 Thr Ser Lys Glu 180 <210> 471 <211> 180 <212> PRT <213> Oryza sativa <400> 471 Met Gly Phe Ile Gly Asp Thr Val Glu Ser Ile Arg Ser Ile Gln Ile 1 5 10 15 Arg Gln Val Leu Ala Gln Ile Ile Ser Leu Gly Met Ile Val Thr Ser 20 25 30 Ala Leu Ile Ile Trp Lys Gly Leu Met Val Ala Thr Gly Ser Glu Ser 35 40 45 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Thr Gly 65 70 75 80 Glu Ile Val Val Phe Asn Ile Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 Arg Val Ile Lys Val His Glu Arg Glu Glu Ser Ala Glu Val Asp Ile 100 105 110 Leu Thr Lys Gly Asp Asn Asn Phe Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 His Gly Gln Leu Trp Leu His Gln His His Ile Met Gly Arg Ala Val 130 135 140 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 Pro Phe Ile Lys Tyr Leu Leu Ile Gly Ala Leu Gly Leu Leu Val Ile 165 170 175 Thr Ser Lys Glu 180 <210> 472 <211> 543 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(543) <400> 472 atg gga ttc atc ggc gat acg gtg gag tcg atc cgc tcg ata cag atc 48 Met Gly Phe Ile Gly Asp Thr Val Glu Ser Ile Arg Ser Ile Gln Ile 1 5 10 15 cgc caa gtc ctc gcg caa atc atc agc ctc ggt atg att gtt acc tcg 96 Arg Gln Val Leu Ala Gln Ile Ile Ser Leu Gly Met Ile Val Thr Ser 20 25 30 gca ctg atc ata tgg aag gga ttg atg gtt gca acg ggg agc gag tcc 144 Ala Leu Ile Ile Trp Lys Gly Leu Met Val Ala Thr Gly Ser Glu Ser 35 40 45 Page 559 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt cca gtg gtt gtg gtc ctt tct ggt agc atg gag cct gga ttt aaa agg 192 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 ggc gat atc ctt ttt cta cac atg agc aaa gat cct atc cgc aca gga 240 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Thr Gly 65 70 75 80 gag ata gtt gtt ttc aac att gat ggc cgt gaa att cca att gtt cac 288 Glu Ile Val Val Phe Asn Ile Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 cgt gtg att aag gtc cat gaa cgc gag gaa agt gct gaa gtt gat atc 336 Arg Val Ile Lys Val His Glu Arg Glu Glu Ser Ala Glu Val Asp Ile 100 105 110 ctc acg aaa ggt gat aat aat ttt ggg gac gac cgt ctt ctt tat gca 384 Leu Thr Lys Gly Asp Asn Asn Phe Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 cat ggg cag ctt tgg ctt cac caa cat cac att atg gga cgg gct gta 432 His Gly Gln Leu Trp Leu His Gln His His Ile Met Gly Arg Ala Val 130 135 140 ggc ttt ctt cca tat gtc ggg tgg gtt aca atc atc atg act gag aaa 480 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 cca ttt ata aag tac ctg ctc atc ggc gct ctg ggc ttg ctg gtc att 528 Pro Phe Ile Lys Tyr Leu Leu Ile Gly Ala Leu Gly Leu Leu Val Ile 165 170 175 aca tcg aaa gag taa 543 Thr Ser Lys Glu 180 <210> 473 <211> 180 <212> PRT <213> Oryza sativa <400> 473 Met Gly Phe Ile Gly Asp Thr Val Glu Ser Ile Arg Ser Ile Gln Ile 1 5 10 15 Arg Gln Val Leu Ala Gln Ile Ile Ser Leu Gly Met Ile Val Thr Ser 20 25 30 Ala Leu Ile Ile Trp Lys Gly Leu Met Val Ala Thr Gly Ser Glu Ser 35 40 45 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Thr Gly 65 70 75 80 Glu Ile Val Val Phe Asn Ile Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 Arg Val Ile Lys Val His Glu Arg Glu Glu Ser Ala Glu Val Asp Ile 100 105 110 Leu Thr Lys Gly Asp Asn Asn Phe Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 His Gly Gln Leu Trp Leu His Gln His His Ile Met Gly Arg Ala Val 130 135 140 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 Pro Phe Ile Lys Tyr Leu Leu Ile Gly Ala Leu Gly Leu Leu Val Ile 165 170 175 Thr Ser Lys Glu 180 <210> 474 <211> 600 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(600) Page 560 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 474 atg ggt tgc tcc tcc tcc gtg cca gct cga agc act gga ggg ttg aac 48 Met Gly Cys Ser Ser Ser Val Pro Ala Arg Ser Thr Gly Gly Leu Asn 1 5 10 15 aat att agc aac gat aac tcc gct act gat tca aag gac ttg cgt gct 96 Asn Ile Ser Asn Asp Asn Ser Ala Thr Asp Ser Lys Asp Leu Arg Ala 20 25 30 aag ttg gta ttg ctt ggt gac tct ggt gta ggg aaa agt tgc att gtt 144 Lys Leu Val Leu Leu Gly Asp Ser Gly Val Gly Lys Ser Cys Ile Val 35 40 45 ctt cgc ttt gtt cgt ggt cag ttt gat ccc act tcc aag gta act gtc 192 Leu Arg Phe Val Arg Gly Gln Phe Asp Pro Thr Ser Lys Val Thr Val 50 55 60 ggt gca tca ttt tta tca caa aca ttg gct ttg gag gac tca aca ata 240 Gly Ala Ser Phe Leu Ser Gln Thr Leu Ala Leu Glu Asp Ser Thr Ile 65 70 75 80 gtg aaa ttt gaa ata tgg gat acc gct gga caa gag agg tat gct gcc 288 Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu Arg Tyr Ala Ala 85 90 95 ttg gca cct ctt tac tac aga gga gct gct gct gca gtt gtt gtc tac 336 Leu Ala Pro Leu Tyr Tyr Arg Gly Ala Ala Ala Ala Val Val Val Tyr 100 105 110 gac ata act agt cca gaa tca ttt agc aaa gca caa tac tgg gtg aag 384 Asp Ile Thr Ser Pro Glu Ser Phe Ser Lys Ala Gln Tyr Trp Val Lys 115 120 125 gaa ctt caa aaa cat ggt agt cct gat att atc atg gtt ttg gtt ggt 432 Glu Leu Gln Lys His Gly Ser Pro Asp Ile Ile Met Val Leu Val Gly 130 135 140 aat aaa gct gat cta cat gaa aat cga cat gta tct tct cag gaa gca 480 Asn Lys Ala Asp Leu His Glu Asn Arg His Val Ser Ser Gln Glu Ala 145 150 155 160 caa gag tat gca gag aag aat aat atg gtt ttc atc gag aca tca gca 528 Gln Glu Tyr Ala Glu Lys Asn Asn Met Val Phe Ile Glu Thr Ser Ala 165 170 175 aag aca gct gat aat ata aac caa gta ttt gag gaa att gcg aag agg 576 Lys Thr Ala Asp Asn Ile Asn Gln Val Phe Glu Glu Ile Ala Lys Arg 180 185 190 ttg ccc agg cca acg gcg tct tga 600 Leu Pro Arg Pro Thr Ala Ser 195 <210> 475 <211> 199 <212> PRT <213> Oryza sativa <400> 475 Met Gly Cys Ser Ser Ser Val Pro Ala Arg Ser Thr Gly Gly Leu Asn 1 5 10 15 Asn Ile Ser Asn Asp Asn Ser Ala Thr Asp Ser Lys Asp Leu Arg Ala 20 25 30 Lys Leu Val Leu Leu Gly Asp Ser Gly Val Gly Lys Ser Cys Ile Val 35 40 45 Leu Arg Phe Val Arg Gly Gln Phe Asp Pro Thr Ser Lys Val Thr Val 50 55 60 Gly Ala Ser Phe Leu Ser Gln Thr Leu Ala Leu Glu Asp Ser Thr Ile 65 70 75 80 Val Lys Phe Glu Ile Trp Asp Thr Ala Gly Gln Glu Arg Tyr Ala Ala 85 90 95 Leu Ala Pro Leu Tyr Tyr Arg Gly Ala Ala Ala Ala Val Val Val Tyr 100 105 110 Asp Ile Thr Ser Pro Glu Ser Phe Ser Lys Ala Gln Tyr Trp Val Lys 115 120 125 Glu Leu Gln Lys His Gly Ser Pro Asp Ile Ile Met Val Leu Val Gly 130 135 140 Asn Lys Ala Asp Leu His Glu Asn Arg His Val Ser Ser Gln Glu Ala 145 150 155 160 Gln Glu Tyr Ala Glu Lys Asn Asn Met Val Phe Ile Glu Thr Ser Ala Page 561 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 165 170 175 Lys Thr Ala Asp Asn Ile Asn Gln Val Phe Glu Glu Ile Ala Lys Arg 180 185 190 Leu Pro Arg Pro Thr Ala Ser 195 <210> 476 <211> 348 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(348) <400> 476 atg tct gat ctc gac gtc cag ctt cca tca gct ttt gat ccg ttt gcg 48 Met Ser Asp Leu Asp Val Gln Leu Pro Ser Ala Phe Asp Pro Phe Ala 1 5 10 15 gaa gcc aat gct gag gac tcc agc gtt ggt gct gga tca aag gac tat 96 Glu Ala Asn Ala Glu Asp Ser Ser Val Gly Ala Gly Ser Lys Asp Tyr 20 25 30 gta cac gtg cgc att cag cag cgc aac gga aga aag agt ctg act act 144 Val His Val Arg Ile Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 gtt cag ggc ttg aag aaa gag tac agt tac aac aaa atc ctc aag gat 192 Val Gln Gly Leu Lys Lys Glu Tyr Ser Tyr Asn Lys Ile Leu Lys Asp 50 55 60 ctg aaa aag gaa ttc tgt tgt aat ggt act gta gtc caa gat cca gag 240 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu 65 70 75 80 tta ggc cag gtc att caa ctt caa ggt gat cag cgt aaa aat gtt gcg 288 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ala 85 90 95 acg ttc cta gtt cag gct gga att gta aag aaa gag agc atc aaa ata 336 Thr Phe Leu Val Gln Ala Gly Ile Val Lys Lys Glu Ser Ile Lys Ile 100 105 110 cac ggg ttt tag 348 His Gly Phe 115 <210> 477 <211> 115 <212> PRT <213> Oryza sativa <400> 477 Met Ser Asp Leu Asp Val Gln Leu Pro Ser Ala Phe Asp Pro Phe Ala 1 5 10 15 Glu Ala Asn Ala Glu Asp Ser Ser Val Gly Ala Gly Ser Lys Asp Tyr 20 25 30 Val His Val Arg Ile Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 Val Gln Gly Leu Lys Lys Glu Tyr Ser Tyr Asn Lys Ile Leu Lys Asp 50 55 60 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu 65 70 75 80 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ala 85 90 95 Thr Phe Leu Val Gln Ala Gly Ile Val Lys Lys Glu Ser Ile Lys Ile 100 105 110 His Gly Phe 115 <210> 478 <211> 768 <212> DNA <213> Oryza sativa Page 562 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(768) <400> 478 atg gcg gtc gtc ggc gtc ctc gcg ctg cag ggc tcc ttc aac gag cac 48 Met Ala Val Val Gly Val Leu Ala Leu Gln Gly Ser Phe Asn Glu His 1 5 10 15 ttg gcc gcg ctg agg agg atc ggg gtg agg ggg gtg gag gtg cgg aag 96 Leu Ala Ala Leu Arg Arg Ile Gly Val Arg Gly Val Glu Val Arg Lys 20 25 30 ccg gag cag ctg cag ggg ctc gac tcg ctc atc atc ccc ggc ggc gag 144 Pro Glu Gln Leu Gln Gly Leu Asp Ser Leu Ile Ile Pro Gly Gly Glu 35 40 45 agc acc acc atg gcc aaa ctc gcc aac tac cac aac ctg ttt cct gca 192 Ser Thr Thr Met Ala Lys Leu Ala Asn Tyr His Asn Leu Phe Pro Ala 50 55 60 ctt cga gaa ttt gtt ggt aca gga agg cct gtc tgg gga act tgt gct 240 Leu Arg Glu Phe Val Gly Thr Gly Arg Pro Val Trp Gly Thr Cys Ala 65 70 75 80 gga ctc atc ttc cta gct aac aag gca gta ggc caa aaa tcc gga ggt 288 Gly Leu Ile Phe Leu Ala Asn Lys Ala Val Gly Gln Lys Ser Gly Gly 85 90 95 cag gag ctt att gga gga cta gat tgt act gtc cac cgg aac ttt ttt 336 Gln Glu Leu Ile Gly Gly Leu Asp Cys Thr Val His Arg Asn Phe Phe 100 105 110 ggg agc cag ctt caa agc ttt gaa acg gaa ctt tca gtg cca atg ctt 384 Gly Ser Gln Leu Gln Ser Phe Glu Thr Glu Leu Ser Val Pro Met Leu 115 120 125 gca gag aag gaa gga ggg agc gat aca tgc cgt ggc gta ttt ata cga 432 Ala Glu Lys Glu Gly Gly Ser Asp Thr Cys Arg Gly Val Phe Ile Arg 130 135 140 gca cct gct atc ttg gat gta ggt tca aat gtt gaa gta ctg gcg gat 480 Ala Pro Ala Ile Leu Asp Val Gly Ser Asn Val Glu Val Leu Ala Asp 145 150 155 160 tgt cct gtt cca tcg gat aga ccc agt att aca ata gcg tct gga gag 528 Cys Pro Val Pro Ser Asp Arg Pro Ser Ile Thr Ile Ala Ser Gly Glu 165 170 175 ggt gtt gag gaa gaa gtg tac tcg aaa gat cgg gta att gtt gct gta 576 Gly Val Glu Glu Glu Val Tyr Ser Lys Asp Arg Val Ile Val Ala Val 180 185 190 agg caa ggg aac atc ctc gct act gct ttt cac cca gaa ttg aca tca 624 Arg Gln Gly Asn Ile Leu Ala Thr Ala Phe His Pro Glu Leu Thr Ser 195 200 205 gac tct aga tgg cat cgg ttc ttc ctg gac atg gat aaa gaa tct gat 672 Asp Ser Arg Trp His Arg Phe Phe Leu Asp Met Asp Lys Glu Ser Asp 210 215 220 aca aaa gcc ttc tct gct ctc tct ctc tca tca tct tca aga gac act 720 Thr Lys Ala Phe Ser Ala Leu Ser Leu Ser Ser Ser Ser Arg Asp Thr 225 230 235 240 caa gat ggg tca aag aat aag cct ctt gat cta ccc atc ttc gag 765 Gln Asp Gly Ser Lys Asn Lys Pro Leu Asp Leu Pro Ile Phe Glu 245 250 255 tag 768 <210> 479 <211> 255 <212> PRT <213> Oryza sativa <400> 479 Met Ala Val Val Gly Val Leu Ala Leu Gln Gly Ser Phe Asn Glu His 1 5 10 15 Leu Ala Ala Leu Arg Arg Ile Gly Val Arg Gly Val Glu Val Arg Lys 20 25 30 Page 563 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Pro Glu Gln Leu Gln Gly Leu Asp Ser Leu Ile Ile Pro Gly Gly Glu 35 40 45 Ser Thr Thr Met Ala Lys Leu Ala Asn Tyr His Asn Leu Phe Pro Ala 50 55 60 Leu Arg Glu Phe Val Gly Thr Gly Arg Pro Val Trp Gly Thr Cys Ala 65 70 75 80 Gly Leu Ile Phe Leu Ala Asn Lys Ala Val Gly Gln Lys Ser Gly Gly 85 90 95 Gln Glu Leu Ile Gly Gly Leu Asp Cys Thr Val His Arg Asn Phe Phe 100 105 110 Gly Ser Gln Leu Gln Ser Phe Glu Thr Glu Leu Ser Val Pro Met Leu 115 120 125 Ala Glu Lys Glu Gly Gly Ser Asp Thr Cys Arg Gly Val Phe Ile Arg 130 135 140 Ala Pro Ala Ile Leu Asp Val Gly Ser Asn Val Glu Val Leu Ala Asp 145 150 155 160 Cys Pro Val Pro Ser Asp Arg Pro Ser Ile Thr Ile Ala Ser Gly Glu 165 170 175 Gly Val Glu Glu Glu Val Tyr Ser Lys Asp Arg Val Ile Val Ala Val 180 185 190 Arg Gln Gly Asn Ile Leu Ala Thr Ala Phe His Pro Glu Leu Thr Ser 195 200 205 Asp Ser Arg Trp His Arg Phe Phe Leu Asp Met Asp Lys Glu Ser Asp 210 215 220 Thr Lys Ala Phe Ser Ala Leu Ser Leu Ser Ser Ser Ser Arg Asp Thr 225 230 235 240 Gln Asp Gly Ser Lys Asn Lys Pro Leu Asp Leu Pro Ile Phe Glu 245 250 255 <210> 480 <211> 783 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(783) <400> 480 atg gcc gtc ggc aag aac aag cgg atc tcg aag ggg aag aag gga tcc 48 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Lys Lys Gly Ser 1 5 10 15 aag aag aag acc gtc gat cct ttt gcg aag aag gat tgg tat gat atc 96 Lys Lys Lys Thr Val Asp Pro Phe Ala Lys Lys Asp Trp Tyr Asp Ile 20 25 30 aag gcc ccg tcg gtg ttc aac gtg aga aac gtc ggg aag acg ctc gtg 144 Lys Ala Pro Ser Val Phe Asn Val Arg Asn Val Gly Lys Thr Leu Val 35 40 45 tcc agg aca cag ggc aca aag att gct tca gag ggc ctc aag cac cgt 192 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 gtg ttt gag gtc tcc ttg gct gat ctt cag aac gat gag gat cag gcg 240 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Asp Gln Ala 65 70 75 80 tac cgt aag atc aga cta cgt gcc gag gat gtg cag ggg aaa aat gtt 288 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Lys Asn Val 85 90 95 ctt aca aac ttc tgg ggc atg agt ttc acg acc gac aag ctc aga tca 336 Leu Thr Asn Phe Trp Gly Met Ser Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 ttg gtc aag aaa tgg cag acg cta ata gag gct cat gtg gat gta aag 384 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 acc act gat aac tac atg ctg cgt ctc ttc tgc att ggc ttc acc aag 432 Thr Thr Asp Asn Tyr Met Leu Arg Leu Phe Cys Ile Gly Phe Thr Lys 130 135 140 agg agg cca aat caa gtc aaa cgg aca tgc tat gct caa gca agc cag 480 Arg Arg Pro Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ala Ser Gln Page 564 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 att cga cag atc cgt cgc aag atg gtg gag atc atg gtg aac cag gca 528 Ile Arg Gln Ile Arg Arg Lys Met Val Glu Ile Met Val Asn Gln Ala 165 170 175 tca tcc tgt gat ctc aag gag ctg gtg tca aaa ttc att cct gag gtg 576 Ser Ser Cys Asp Leu Lys Glu Leu Val Ser Lys Phe Ile Pro Glu Val 180 185 190 att ggg aag gaa atc gag aag gcc aca tca agc atc ttc ccg ctt cag 624 Ile Gly Lys Glu Ile Glu Lys Ala Thr Ser Ser Ile Phe Pro Leu Gln 195 200 205 aat gtg ttt gtg cgc aaa gtc aag atc ctc aag gcc cca aaa ttt gac 672 Asn Val Phe Val Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 ctg ggc aag ctt atg gag gtt cat gga gat tac aag gag gac gtt ggg 720 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Lys Glu Asp Val Gly 225 230 235 240 acg aag ctc gag agg cct gca gaa gat gag gtc gtg gta gga cag gag 768 Thr Lys Leu Glu Arg Pro Ala Glu Asp Glu Val Val Val Gly Gln Glu 245 250 255 gtc act gcc gag tag 783 Val Thr Ala Glu 260 <210> 481 <211> 260 <212> PRT <213> Oryza sativa <400> 481 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Lys Lys Gly Ser 1 5 10 15 Lys Lys Lys Thr Val Asp Pro Phe Ala Lys Lys Asp Trp Tyr Asp Ile 20 25 30 Lys Ala Pro Ser Val Phe Asn Val Arg Asn Val Gly Lys Thr Leu Val 35 40 45 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Asn Asp Glu Asp Gln Ala 65 70 75 80 Tyr Arg Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Lys Asn Val 85 90 95 Leu Thr Asn Phe Trp Gly Met Ser Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Leu Val Lys Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 Thr Thr Asp Asn Tyr Met Leu Arg Leu Phe Cys Ile Gly Phe Thr Lys 130 135 140 Arg Arg Pro Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ala Ser Gln 145 150 155 160 Ile Arg Gln Ile Arg Arg Lys Met Val Glu Ile Met Val Asn Gln Ala 165 170 175 Ser Ser Cys Asp Leu Lys Glu Leu Val Ser Lys Phe Ile Pro Glu Val 180 185 190 Ile Gly Lys Glu Ile Glu Lys Ala Thr Ser Ser Ile Phe Pro Leu Gln 195 200 205 Asn Val Phe Val Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Lys Glu Asp Val Gly 225 230 235 240 Thr Lys Leu Glu Arg Pro Ala Glu Asp Glu Val Val Val Gly Gln Glu 245 250 255 Val Thr Ala Glu 260 <210> 482 <211> 297 <212> DNA <213> Oryza sativa Page 565 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <221> CDS <222> (1)..(297) <400> 482 atg gcg agg cgg ctg atc ccg tcg ctg aac cgc gtg ctg gtg gag aag 48 Met Ala Arg Arg Leu Ile Pro Ser Leu Asn Arg Val Leu Val Glu Lys 1 5 10 15 ctg gtg cag ccc aag aag agc gcc ggc ggc atc ctc ctc cct gag acg 96 Leu Val Gln Pro Lys Lys Ser Ala Gly Gly Ile Leu Leu Pro Glu Thr 20 25 30 tcc aag cag ctc aac tct ggt aaa gtg gtg gct gtt ggc cct ggc gaa 144 Ser Lys Gln Leu Asn Ser Gly Lys Val Val Ala Val Gly Pro Gly Glu 35 40 45 cgt gac aag gat ggc aag ctg atc cct gtt gct ctc aag gaa gga gac 192 Arg Asp Lys Asp Gly Lys Leu Ile Pro Val Ala Leu Lys Glu Gly Asp 50 55 60 act gtt ctc ctg cct gaa tat ggt gga ctc gaa gtc aag ctt gct gct 240 Thr Val Leu Leu Pro Glu Tyr Gly Gly Leu Glu Val Lys Leu Ala Ala 65 70 75 80 gaa aaa gag tac ctt ctc ttc aga gag cat gac atc ttg ggc acc ctt 288 Glu Lys Glu Tyr Leu Leu Phe Arg Glu His Asp Ile Leu Gly Thr Leu 85 90 95 gtg gac tga 297 Val Asp <210> 483 <211> 98 <212> PRT <213> Oryza sativa <400> 483 Met Ala Arg Arg Leu Ile Pro Ser Leu Asn Arg Val Leu Val Glu Lys 1 5 10 15 Leu Val Gln Pro Lys Lys Ser Ala Gly Gly Ile Leu Leu Pro Glu Thr 20 25 30 Ser Lys Gln Leu Asn Ser Gly Lys Val Val Ala Val Gly Pro Gly Glu 35 40 45 Arg Asp Lys Asp Gly Lys Leu Ile Pro Val Ala Leu Lys Glu Gly Asp 50 55 60 Thr Val Leu Leu Pro Glu Tyr Gly Gly Leu Glu Val Lys Leu Ala Ala 65 70 75 80 Glu Lys Glu Tyr Leu Leu Phe Arg Glu His Asp Ile Leu Gly Thr Leu 85 90 95 Val Asp <210> 484 <211> 429 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(429) <400> 484 atg atc cgg ttc atc ctg ctg cag aat cgg cag ggg aag acg cgg ctg 48 Met Ile Arg Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 gcc aag tac tac gtc ccg ctc gag gac tcg gag aag cac aag gtc gag 96 Ala Lys Tyr Tyr Val Pro Leu Glu Asp Ser Glu Lys His Lys Val Glu 20 25 30 tac gag gtg cat cgg ctg gtg gtc aac cgg gat ccc aag ttc acc aac 144 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Pro Lys Phe Thr Asn 35 40 45 Page 566 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttc gtt gag ttc cgg acg cat aaa gtt ata tac agg cga tat gca gga 192 Phe Val Glu Phe Arg Thr His Lys Val Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 ctg ttt ttc tca atg tgt gtg gat atc act gac aat gag ttg gca tac 240 Leu Phe Phe Ser Met Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 ttg gaa tgc atc cac ttg ttt gtc gag ata tta gat cat ttc ttc agc 288 Leu Glu Cys Ile His Leu Phe Val Glu Ile Leu Asp His Phe Phe Ser 85 90 95 aat gtg tgt gaa ctc gac tta gta ttt aat ttc cac aag gtt tat ttg 336 Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe His Lys Val Tyr Leu 100 105 110 ata ttg gat gag ttt att ctc gct gga gaa ctt caa gag aca agc aaa 384 Ile Leu Asp Glu Phe Ile Leu Ala Gly Glu Leu Gln Glu Thr Ser Lys 115 120 125 agg gca ata ata gag cga atg ggt gag ctt gag aag ctg gaa taa 429 Arg Ala Ile Ile Glu Arg Met Gly Glu Leu Glu Lys Leu Glu 130 135 140 <210> 485 <211> 142 <212> PRT <213> Oryza sativa <400> 485 Met Ile Arg Phe Ile Leu Leu Gln Asn Arg Gln Gly Lys Thr Arg Leu 1 5 10 15 Ala Lys Tyr Tyr Val Pro Leu Glu Asp Ser Glu Lys His Lys Val Glu 20 25 30 Tyr Glu Val His Arg Leu Val Val Asn Arg Asp Pro Lys Phe Thr Asn 35 40 45 Phe Val Glu Phe Arg Thr His Lys Val Ile Tyr Arg Arg Tyr Ala Gly 50 55 60 Leu Phe Phe Ser Met Cys Val Asp Ile Thr Asp Asn Glu Leu Ala Tyr 65 70 75 80 Leu Glu Cys Ile His Leu Phe Val Glu Ile Leu Asp His Phe Phe Ser 85 90 95 Asn Val Cys Glu Leu Asp Leu Val Phe Asn Phe His Lys Val Tyr Leu 100 105 110 Ile Leu Asp Glu Phe Ile Leu Ala Gly Glu Leu Gln Glu Thr Ser Lys 115 120 125 Arg Ala Ile Ile Glu Arg Met Gly Glu Leu Glu Lys Leu Glu 130 135 140 <210> 486 <211> 411 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(411) <400> 486 atg gcc cgc acg aag cag acg gcg cgc aag tcc acc ggc ggg aag gcg 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccg agg aag cag ctg gcg acc aag gcg gcg cgc aag tcg gcg ccg gcc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acc ggc ggc gtg aag aag ccg cac cgc ttc agg ccg ggc acc gtc gcg 144 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 ctc cgt gag atc cgc aag tac cag aag agc acg gag ctg ctc atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctc ccc ttc cag cgc ctc gtc cgc gag atc gcc cag gac ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys Page 567 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 65 70 75 80 acc gac ctc cgc ttc cag agc tcc gcc gtc gcc gcg ctg cag gag gcc 288 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gcg gag gcg tac ctc gtc ggg ctc ttc gag gac act aac ctg tgc gcc 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 atc cac gcc aag cgc gtc acc atc atg ccc aag gac atc cag ctc gcc 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 cgc cgc atc cgc ggt gag cgc gcc tga 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 487 <211> 136 <212> PRT <213> Oryza sativa <400> 487 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 488 <211> 1005 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(1005) <400> 488 atg gtg gat tgc ctt gcc atc ttc ggg gca ggt gcg atg ctt ggg gat 48 Met Val Asp Cys Leu Ala Ile Phe Gly Ala Gly Ala Met Leu Gly Asp 1 5 10 15 tca ttt ctt cat caa ctg cca cat gcc ttt ggt gga ggg cat tct cat 96 Ser Phe Leu His Gln Leu Pro His Ala Phe Gly Gly Gly His Ser His 20 25 30 aca cat gat cat cag aat cat aat cat tct cat gag cat tca cat gca 144 Thr His Asp His Gln Asn His Asn His Ser His Glu His Ser His Ala 35 40 45 cac tct ctg gaa gat ctt tct att ggt ttg tct gtt cta ttt ggc att 192 His Ser Leu Glu Asp Leu Ser Ile Gly Leu Ser Val Leu Phe Gly Ile 50 55 60 gtg ttt ttc ttt att gtt gag aag att gtg agg tat gtg gaa gac aat 240 Val Phe Phe Phe Ile Val Glu Lys Ile Val Arg Tyr Val Glu Asp Asn 65 70 75 80 tct cag aaa ggg gct cat ggc atg ggc cac cat cat cac cat cat aaa 288 Ser Gln Lys Gly Ala His Gly Met Gly His His His His His His Lys 85 90 95 cga cac gat agg agc gac aag gcc aag ttg aat cac gca gaa aag gat 336 Page 568 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Arg His Asp Arg Ser Asp Lys Ala Lys Leu Asn His Ala Glu Lys Asp 100 105 110 cat gag gat aaa ggc gta aat caa gca gaa aag gaa cct tcg cat gat 384 His Glu Asp Lys Gly Val Asn Gln Ala Glu Lys Glu Pro Ser His Asp 115 120 125 ggt gca att gag aaa aca gat ggt gta act cgt gct gat tca aaa tct 432 Gly Ala Ile Glu Lys Thr Asp Gly Val Thr Arg Ala Asp Ser Lys Ser 130 135 140 gca atc cgt aag agg ggc tta tct tct ggt tcc aat tcc gct gat aga 480 Ala Ile Arg Lys Arg Gly Leu Ser Ser Gly Ser Asn Ser Ala Asp Arg 145 150 155 160 gag cct gtc aat tct gaa agt gac cct gcc cct aac aaa gca tta tca 528 Glu Pro Val Asn Ser Glu Ser Asp Pro Ala Pro Asn Lys Ala Leu Ser 165 170 175 agt gaa gat tcc tct gtt tcc aat tcg aat atg gtg ttc ggc tac ctc 576 Ser Glu Asp Ser Ser Val Ser Asn Ser Asn Met Val Phe Gly Tyr Leu 180 185 190 aac ctt ttc tca gat ggt gtt cat aac ttt act gat ggg atg gcc cta 624 Asn Leu Phe Ser Asp Gly Val His Asn Phe Thr Asp Gly Met Ala Leu 195 200 205 ggg agt gct ttt ctg cta cat ggt tct gtt gga gga tgg tcg aga act 672 Gly Ser Ala Phe Leu Leu His Gly Ser Val Gly Gly Trp Ser Arg Thr 210 215 220 cta ttt ctg ctt gca cat gaa ctt cct caa gag gtc gga gat ttt ggt 720 Leu Phe Leu Leu Ala His Glu Leu Pro Gln Glu Val Gly Asp Phe Gly 225 230 235 240 atc ctg gtg cgc tca gga ttc act gta act aaa gcc cta ttt ttc aat 768 Ile Leu Val Arg Ser Gly Phe Thr Val Thr Lys Ala Leu Phe Phe Asn 245 250 255 ttt ctc tct gcg ttg gtt gct ctt gct gga aca gca ctg gca ttg tct 816 Phe Leu Ser Ala Leu Val Ala Leu Ala Gly Thr Ala Leu Ala Leu Ser 260 265 270 ttg gga aaa gat cca ggg cat tct tct ttg att gag gga ttc act gct 864 Leu Gly Lys Asp Pro Gly His Ser Ser Leu Ile Glu Gly Phe Thr Ala 275 280 285 ggt ggc ttt att tat att gct gtt gct gga gtc ctc cca gag atg aat 912 Gly Gly Phe Ile Tyr Ile Ala Val Ala Gly Val Leu Pro Glu Met Asn 290 295 300 gat cag aaa aca acc gtc aaa agc tcg atg att cag ttg gtt tcc ctg 960 Asp Gln Lys Thr Thr Val Lys Ser Ser Met Ile Gln Leu Val Ser Leu 305 310 315 320 aca atg gga atg ctg gtt gcc ctc ggc ata tct cta gta gaa tga 1005 Thr Met Gly Met Leu Val Ala Leu Gly Ile Ser Leu Val Glu 325 330 <210> 489 <211> 334 <212> PRT <213> Oryza sativa <400> 489 Met Val Asp Cys Leu Ala Ile Phe Gly Ala Gly Ala Met Leu Gly Asp 1 5 10 15 Ser Phe Leu His Gln Leu Pro His Ala Phe Gly Gly Gly His Ser His 20 25 30 Thr His Asp His Gln Asn His Asn His Ser His Glu His Ser His Ala 35 40 45 His Ser Leu Glu Asp Leu Ser Ile Gly Leu Ser Val Leu Phe Gly Ile 50 55 60 Val Phe Phe Phe Ile Val Glu Lys Ile Val Arg Tyr Val Glu Asp Asn 65 70 75 80 Ser Gln Lys Gly Ala His Gly Met Gly His His His His His His Lys 85 90 95 Arg His Asp Arg Ser Asp Lys Ala Lys Leu Asn His Ala Glu Lys Asp 100 105 110 His Glu Asp Lys Gly Val Asn Gln Ala Glu Lys Glu Pro Ser His Asp 115 120 125 Gly Ala Ile Glu Lys Thr Asp Gly Val Thr Arg Ala Asp Ser Lys Ser Page 569 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 130 135 140 Ala Ile Arg Lys Arg Gly Leu Ser Ser Gly Ser Asn Ser Ala Asp Arg 145 150 155 160 Glu Pro Val Asn Ser Glu Ser Asp Pro Ala Pro Asn Lys Ala Leu Ser 165 170 175 Ser Glu Asp Ser Ser Val Ser Asn Ser Asn Met Val Phe Gly Tyr Leu 180 185 190 Asn Leu Phe Ser Asp Gly Val His Asn Phe Thr Asp Gly Met Ala Leu 195 200 205 Gly Ser Ala Phe Leu Leu His Gly Ser Val Gly Gly Trp Ser Arg Thr 210 215 220 Leu Phe Leu Leu Ala His Glu Leu Pro Gln Glu Val Gly Asp Phe Gly 225 230 235 240 Ile Leu Val Arg Ser Gly Phe Thr Val Thr Lys Ala Leu Phe Phe Asn 245 250 255 Phe Leu Ser Ala Leu Val Ala Leu Ala Gly Thr Ala Leu Ala Leu Ser 260 265 270 Leu Gly Lys Asp Pro Gly His Ser Ser Leu Ile Glu Gly Phe Thr Ala 275 280 285 Gly Gly Phe Ile Tyr Ile Ala Val Ala Gly Val Leu Pro Glu Met Asn 290 295 300 Asp Gln Lys Thr Thr Val Lys Ser Ser Met Ile Gln Leu Val Ser Leu 305 310 315 320 Thr Met Gly Met Leu Val Ala Leu Gly Ile Ser Leu Val Glu 325 330 <210> 490 <211> 432 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(432) <400> 490 atg ggg atc cgg ttc gtg ctg ttc gtg aac aag cag ggg cag acg cgg 48 Met Gly Ile Arg Phe Val Leu Phe Val Asn Lys Gln Gly Gln Thr Arg 1 5 10 15 ctg gcc cag tac tac gag cac ctc tcc atc gac gag cgc cgc gcc ctc 96 Leu Ala Gln Tyr Tyr Glu His Leu Ser Ile Asp Glu Arg Arg Ala Leu 20 25 30 gag ggc gag atc gtc cgc aag tgc ctc gcc cgc acc gac cag cag tgt 144 Glu Gly Glu Ile Val Arg Lys Cys Leu Ala Arg Thr Asp Gln Gln Cys 35 40 45 tcg ttc gtg gag cac cgg aac tac aag gtg gtg tac cgg cgg tac gct 192 Ser Phe Val Glu His Arg Asn Tyr Lys Val Val Tyr Arg Arg Tyr Ala 50 55 60 tcc ctc ttc ttc ctc gtc ggc gtc gac aac gac gag aat gag cta gct 240 Ser Leu Phe Phe Leu Val Gly Val Asp Asn Asp Glu Asn Glu Leu Ala 65 70 75 80 att ctc gaa ttc att cat ctt ttt gtg gaa act atg gac cgc cac ttc 288 Ile Leu Glu Phe Ile His Leu Phe Val Glu Thr Met Asp Arg His Phe 85 90 95 gga aat gtg tgt gaa ctc gac atc atg ttc cat cta gag aag gtg cac 336 Gly Asn Val Cys Glu Leu Asp Ile Met Phe His Leu Glu Lys Val His 100 105 110 ttc atg ctg gaa gag atg gtg atg aat ggc tgc ata gta gag aca agt 384 Phe Met Leu Glu Glu Met Val Met Asn Gly Cys Ile Val Glu Thr Ser 115 120 125 aaa cag aac atc tta gca cca atc cag ctt atg gag aaa act tct 429 Lys Gln Asn Ile Leu Ala Pro Ile Gln Leu Met Glu Lys Thr Ser 130 135 140 tag 432 <210> 491 Page 570 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 143 <212> PRT <213> Oryza sativa <400> 491 Met Gly Ile Arg Phe Val Leu Phe Val Asn Lys Gln Gly Gln Thr Arg 1 5 10 15 Leu Ala Gln Tyr Tyr Glu His Leu Ser Ile Asp Glu Arg Arg Ala Leu 20 25 30 Glu Gly Glu Ile Val Arg Lys Cys Leu Ala Arg Thr Asp Gln Gln Cys 35 40 45 Ser Phe Val Glu His Arg Asn Tyr Lys Val Val Tyr Arg Arg Tyr Ala 50 55 60 Ser Leu Phe Phe Leu Val Gly Val Asp Asn Asp Glu Asn Glu Leu Ala 65 70 75 80 Ile Leu Glu Phe Ile His Leu Phe Val Glu Thr Met Asp Arg His Phe 85 90 95 Gly Asn Val Cys Glu Leu Asp Ile Met Phe His Leu Glu Lys Val His 100 105 110 Phe Met Leu Glu Glu Met Val Met Asn Gly Cys Ile Val Glu Thr Ser 115 120 125 Lys Gln Asn Ile Leu Ala Pro Ile Gln Leu Met Glu Lys Thr Ser 130 135 140 <210> 492 <211> 486 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(486) <400> 492 atg atc aat ttc gtg ctc ctg atc agc cgc cag ggc aag gtg agg ctt 48 Met Ile Asn Phe Val Leu Leu Ile Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 acc aag tgg tac tcg cct tac acc cag aag gag agg act aag gtt atc 96 Thr Lys Trp Tyr Ser Pro Tyr Thr Gln Lys Glu Arg Thr Lys Val Ile 20 25 30 cgt gag ctc agt ggg ctc att cta aca cgc ggg cca aaa ctc tgc aac 144 Arg Glu Leu Ser Gly Leu Ile Leu Thr Arg Gly Pro Lys Leu Cys Asn 35 40 45 ttt gtt gag tgg aag ggt tac aag gtt gtg tac aga agg tat gcg agc 192 Phe Val Glu Trp Lys Gly Tyr Lys Val Val Tyr Arg Arg Tyr Ala Ser 50 55 60 ctg tat ttc tgc atg tgc att gat gct gag gac aat gag ctc gag gtc 240 Leu Tyr Phe Cys Met Cys Ile Asp Ala Glu Asp Asn Glu Leu Glu Val 65 70 75 80 ctt gaa att atc cat cac ttc gtt gaa gta ctg gac cga tat ttt ggc 288 Leu Glu Ile Ile His His Phe Val Glu Val Leu Asp Arg Tyr Phe Gly 85 90 95 agc gta tgc gag ctg gat ttg ata ttc aat ttc cac aag gcc tac tac 336 Ser Val Cys Glu Leu Asp Leu Ile Phe Asn Phe His Lys Ala Tyr Tyr 100 105 110 ata ctt gat gaa att ctc atc gct ggt gag ctt caa gaa tct agc aag 384 Ile Leu Asp Glu Ile Leu Ile Ala Gly Glu Leu Gln Glu Ser Ser Lys 115 120 125 aaa aat gtt gca aga cta att gct gca cag gat tca ttg gta gag gca 432 Lys Asn Val Ala Arg Leu Ile Ala Ala Gln Asp Ser Leu Val Glu Ala 130 135 140 gct aaa gag gaa gct agc tct ata agc aac atc att gcc cag gct aca 480 Ala Lys Glu Glu Ala Ser Ser Ile Ser Asn Ile Ile Ala Gln Ala Thr 145 150 155 160 aaa taa 486 Lys Page 571 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 493 <211> 161 <212> PRT <213> Oryza sativa <400> 493 Met Ile Asn Phe Val Leu Leu Ile Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 Thr Lys Trp Tyr Ser Pro Tyr Thr Gln Lys Glu Arg Thr Lys Val Ile 20 25 30 Arg Glu Leu Ser Gly Leu Ile Leu Thr Arg Gly Pro Lys Leu Cys Asn 35 40 45 Phe Val Glu Trp Lys Gly Tyr Lys Val Val Tyr Arg Arg Tyr Ala Ser 50 55 60 Leu Tyr Phe Cys Met Cys Ile Asp Ala Glu Asp Asn Glu Leu Glu Val 65 70 75 80 Leu Glu Ile Ile His His Phe Val Glu Val Leu Asp Arg Tyr Phe Gly 85 90 95 Ser Val Cys Glu Leu Asp Leu Ile Phe Asn Phe His Lys Ala Tyr Tyr 100 105 110 Ile Leu Asp Glu Ile Leu Ile Ala Gly Glu Leu Gln Glu Ser Ser Lys 115 120 125 Lys Asn Val Ala Arg Leu Ile Ala Ala Gln Asp Ser Leu Val Glu Ala 130 135 140 Ala Lys Glu Glu Ala Ser Ser Ile Ser Asn Ile Ile Ala Gln Ala Thr 145 150 155 160 Lys <210> 494 <211> 648 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(648) <400> 494 atg gcg tcc agc gcg tcg cgg ttc atc aag tgc gtc acg gtc ggg gac 48 Met Ala Ser Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp 1 5 10 15 ggc gcc gtc ggc aag acc tgc atg ctc atc tgc tac acc agc aac aag 96 Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn Lys 20 25 30 ttc ccc act gat tac gta ccc act gtt ttt gac aat ttc agt gca aac 144 Phe Pro Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn 35 40 45 gtg gtg gtc gac ggc acc acg gtg aat ttg ggt ctc tgg gat act gca 192 Val Val Val Asp Gly Thr Thr Val Asn Leu Gly Leu Trp Asp Thr Ala 50 55 60 ggg cag gaa gat tac aac aga ttg agg ccg cta agc tac cgt ggc gcc 240 Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala 65 70 75 80 gat gtc ttt gtg ctt gcc ttc tcc cta gtg agc cga gct agc tat gag 288 Asp Val Phe Val Leu Ala Phe Ser Leu Val Ser Arg Ala Ser Tyr Glu 85 90 95 aat gtc atg aag aag tgg tta cca gag ctt cag cat tat gca cca ggg 336 Asn Val Met Lys Lys Trp Leu Pro Glu Leu Gln His Tyr Ala Pro Gly 100 105 110 gtg cca att gtg ttg gtt ggg acc aaa ttg gat ctt cgt gaa gat aaa 384 Val Pro Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Lys 115 120 125 cac tac tta ctt gac cat cct agc ttg gtg cct gtg act aca gca cag 432 His Tyr Leu Leu Asp His Pro Ser Leu Val Pro Val Thr Thr Ala Gln 130 135 140 gga gag gaa ctc cgc aag cac att ggc gca acg tgt tac atc gaa tgc 480 Gly Glu Glu Leu Arg Lys His Ile Gly Ala Thr Cys Tyr Ile Glu Cys Page 572 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 145 150 155 160 agc tca aag aca cag cag aat gta aaa gct gtg ttt gat gct gcc atc 528 Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile 165 170 175 aag gta gta atc aag cct cca aca aag cag agg gac agg aag aag aag 576 Lys Val Val Ile Lys Pro Pro Thr Lys Gln Arg Asp Arg Lys Lys Lys 180 185 190 aaa aca cgg cgc gga tgt tct ttc ttc tgc aag ggt gtc atg tcc aga 624 Lys Thr Arg Arg Gly Cys Ser Phe Phe Cys Lys Gly Val Met Ser Arg 195 200 205 aga agg cta gta tgc ttc aag tga 648 Arg Arg Leu Val Cys Phe Lys 210 215 <210> 495 <211> 215 <212> PRT <213> Oryza sativa <400> 495 Met Ala Ser Ser Ala Ser Arg Phe Ile Lys Cys Val Thr Val Gly Asp 1 5 10 15 Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Ser Asn Lys 20 25 30 Phe Pro Thr Asp Tyr Val Pro Thr Val Phe Asp Asn Phe Ser Ala Asn 35 40 45 Val Val Val Asp Gly Thr Thr Val Asn Leu Gly Leu Trp Asp Thr Ala 50 55 60 Gly Gln Glu Asp Tyr Asn Arg Leu Arg Pro Leu Ser Tyr Arg Gly Ala 65 70 75 80 Asp Val Phe Val Leu Ala Phe Ser Leu Val Ser Arg Ala Ser Tyr Glu 85 90 95 Asn Val Met Lys Lys Trp Leu Pro Glu Leu Gln His Tyr Ala Pro Gly 100 105 110 Val Pro Ile Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu Asp Lys 115 120 125 His Tyr Leu Leu Asp His Pro Ser Leu Val Pro Val Thr Thr Ala Gln 130 135 140 Gly Glu Glu Leu Arg Lys His Ile Gly Ala Thr Cys Tyr Ile Glu Cys 145 150 155 160 Ser Ser Lys Thr Gln Gln Asn Val Lys Ala Val Phe Asp Ala Ala Ile 165 170 175 Lys Val Val Ile Lys Pro Pro Thr Lys Gln Arg Asp Arg Lys Lys Lys 180 185 190 Lys Thr Arg Arg Gly Cys Ser Phe Phe Cys Lys Gly Val Met Ser Arg 195 200 205 Arg Arg Leu Val Cys Phe Lys 210 215 <210> 496 <211> 450 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(450) <400> 496 atg gcg gac cag ctc acc gac gag cag atc gcc gag ttc aag gag gcg 48 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ala Glu Phe Lys Glu Ala 1 5 10 15 ttc agc ctc ttc gac aag gac ggc gac ggt tgc atc act act aag gag 96 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 ctt gga acc gtg atg cgg tcc ctt ggt cag aac cca act gag gcg gag 144 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Page 573 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ctg cag gac atg atc aac gag gtt gat gct gat ggc aat ggg acc att 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 gac ttc cca gag ttc ctg aac ctg atg gcg aag aag atg aag gat acc 240 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Lys Lys Met Lys Asp Thr 65 70 75 80 gac tct gag gag gag ctc aag gag gcc ttc cgt gtg ttt gac aag gac 288 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 cag aac ggt ttc atc tcg gct gct gag ctc cgc cac gtc atg acc aac 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 ctt ggt gag aag ctg acc gac gag gaa gtc gac gag atg atc cgt gag 384 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 gct gac gtc gat ggc gat ggc cag atc aac tac gag gag ttc gtt aag 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 gtc atg atg gcc aag tga 450 Val Met Met Ala Lys 145 <210> 497 <211> 149 <212> PRT <213> Oryza sativa <400> 497 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ala Glu Phe Lys Glu Ala 1 5 10 15 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Lys Lys Met Lys Asp Thr 65 70 75 80 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Val Met Met Ala Lys 145 <210> 498 <211> 342 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(342) <400> 498 atg tct gaa tta gac gat caa att cct act gcc ttc gat cct ttt gct 48 Met Ser Glu Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 gat gca aat gct gat gac tcg ggt gct ggg tca aag gag tat gtg cat 96 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 att cgt gta cag cag cga aat ggt agg aaa agc ctg aca acc gtt cag 144 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 Page 574 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gga ttg aaa aag gaa ttc agc tat aac aag ata ctt aaa gac gtc aag 192 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 aaa gag ttc tgt tgc aat gga aca gtt gtt cag gac cca gaa cta gga 240 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 cag gtt att caa ctt caa ggt gat cag agg aag aat gtt tct acc ttc 288 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 cta gtc cag gct ggt atc gtg aag aag gat cat atc aag att cat ggt 336 Leu Val Gln Ala Gly Ile Val Lys Lys Asp His Ile Lys Ile His Gly 100 105 110 ttc tga 342 Phe <210> 499 <211> 113 <212> PRT <213> Oryza sativa <400> 499 Met Ser Glu Leu Asp Asp Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 Asp Ala Asn Ala Asp Asp Ser Gly Ala Gly Ser Lys Glu Tyr Val His 20 25 30 Ile Arg Val Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr Val Gln 35 40 45 Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp Val Lys 50 55 60 Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu Leu Gly 65 70 75 80 Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser Thr Phe 85 90 95 Leu Val Gln Ala Gly Ile Val Lys Lys Asp His Ile Lys Ile His Gly 100 105 110 Phe <210> 500 <211> 1074 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(1074) <400> 500 atg agt gac atg gct gct gaa tgt ggg agt ggc aac tgt gat gct tgg 48 Met Ser Asp Met Ala Ala Glu Cys Gly Ser Gly Asn Cys Asp Ala Trp 1 5 10 15 gca gcg aga gat cct tcc gga atc ctc tcc ccg tac aaa ttc aac cgc 96 Ala Ala Arg Asp Pro Ser Gly Ile Leu Ser Pro Tyr Lys Phe Asn Arg 20 25 30 agg gaa gta cag agt gaa gat gtt tct ttg agg atc aca cac tgt gga 144 Arg Glu Val Gln Ser Glu Asp Val Ser Leu Arg Ile Thr His Cys Gly 35 40 45 gta tgt tat gct gat gtc att tgg aca cgg aat atg ttc aac gat tcg 192 Val Cys Tyr Ala Asp Val Ile Trp Thr Arg Asn Met Phe Asn Asp Ser 50 55 60 ata tac cct ttg gtt cct ggg cac gag ata gct gga gtt gta act gag 240 Ile Tyr Pro Leu Val Pro Gly His Glu Ile Ala Gly Val Val Thr Glu 65 70 75 80 gtt ggt gca gac gtc aag ggg ttc aaa gtg ggc gac cat gta ggt gtt 288 Val Gly Ala Asp Val Lys Gly Phe Lys Val Gly Asp His Val Gly Val 85 90 95 ggc gta tat gtg aat tca tgt cag gac tgc gag aac tgc aat agc tct 336 Page 575 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gly Val Tyr Val Asn Ser Cys Gln Asp Cys Glu Asn Cys Asn Ser Ser 100 105 110 ctg gag aac cac tgc tcg aaa tgt gtc gtc act tac aac agt gtt gat 384 Leu Glu Asn His Cys Ser Lys Cys Val Val Thr Tyr Asn Ser Val Asp 115 120 125 tca gac ggg acc gta aca aag ggt gga tat tcc agt cat ata cta gtg 432 Ser Asp Gly Thr Val Thr Lys Gly Gly Tyr Ser Ser His Ile Leu Val 130 135 140 cat caa agg tac tgc ttt aaa ata cct gct gac tac cct ttg tca aag 480 His Gln Arg Tyr Cys Phe Lys Ile Pro Ala Asp Tyr Pro Leu Ser Lys 145 150 155 160 gca gca cca ctg ctt tgt gcg gga att acc gta tat act cca atg ata 528 Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Thr Pro Met Ile 165 170 175 cga cat aac atg aac caa cca ggg aag tca ctt ggc gtc att gga cta 576 Arg His Asn Met Asn Gln Pro Gly Lys Ser Leu Gly Val Ile Gly Leu 180 185 190 ggt ggg ttg ggt ccc atg gca gta aaa ttt ggg aaa gcc ttt gga ctc 624 Gly Gly Leu Gly Pro Met Ala Val Lys Phe Gly Lys Ala Phe Gly Leu 195 200 205 aaa gtg aca gtt ttt agt aca agt gaa tca aag aga gaa gaa gct atc 672 Lys Val Thr Val Phe Ser Thr Ser Glu Ser Lys Arg Glu Glu Ala Ile 210 215 220 aac ctt ctt ggt gca gat aat ttt gtg ata tca tca gat gaa aat cag 720 Asn Leu Leu Gly Ala Asp Asn Phe Val Ile Ser Ser Asp Glu Asn Gln 225 230 235 240 atg gag tca ctg aaa agt tcc ctt cac ttc att att gat act gca tct 768 Met Glu Ser Leu Lys Ser Ser Leu His Phe Ile Ile Asp Thr Ala Ser 245 250 255 ggt gat cac cag ttc gat cct tat ctc tcg ctt ctg aaa gtt ggt ggt 816 Gly Asp His Gln Phe Asp Pro Tyr Leu Ser Leu Leu Lys Val Gly Gly 260 265 270 gta atg gtg cta ctt agc ttc cca agt gaa atc aaa gtt cat cct gaa 864 Val Met Val Leu Leu Ser Phe Pro Ser Glu Ile Lys Val His Pro Glu 275 280 285 aac ctt aat ctc gct gcg cgg agc tta gct ggt agt gta aca ggg ggt 912 Asn Leu Asn Leu Ala Ala Arg Ser Leu Ala Gly Ser Val Thr Gly Gly 290 295 300 aca aag gat atc cag gag atg ata aac ttc tgt gct gca aac aat gtt 960 Thr Lys Asp Ile Gln Glu Met Ile Asn Phe Cys Ala Ala Asn Asn Val 305 310 315 320 tac cca gat ata gag atg atc aag ata gac tac gtc aac gag gct ctt 1008 Tyr Pro Asp Ile Glu Met Ile Lys Ile Asp Tyr Val Asn Glu Ala Leu 325 330 335 cag agg ctc atc aac cgg gat gtg aga ttc cgc ttt gta atc gac atc 1056 Gln Arg Leu Ile Asn Arg Asp Val Arg Phe Arg Phe Val Ile Asp Ile 340 345 350 gag aac tct ttc aag tag 1074 Glu Asn Ser Phe Lys 355 <210> 501 <211> 357 <212> PRT <213> Oryza sativa <400> 501 Met Ser Asp Met Ala Ala Glu Cys Gly Ser Gly Asn Cys Asp Ala Trp 1 5 10 15 Ala Ala Arg Asp Pro Ser Gly Ile Leu Ser Pro Tyr Lys Phe Asn Arg 20 25 30 Arg Glu Val Gln Ser Glu Asp Val Ser Leu Arg Ile Thr His Cys Gly 35 40 45 Val Cys Tyr Ala Asp Val Ile Trp Thr Arg Asn Met Phe Asn Asp Ser 50 55 60 Ile Tyr Pro Leu Val Pro Gly His Glu Ile Ala Gly Val Val Thr Glu 65 70 75 80 Val Gly Ala Asp Val Lys Gly Phe Lys Val Gly Asp His Val Gly Val Page 576 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 Gly Val Tyr Val Asn Ser Cys Gln Asp Cys Glu Asn Cys Asn Ser Ser 100 105 110 Leu Glu Asn His Cys Ser Lys Cys Val Val Thr Tyr Asn Ser Val Asp 115 120 125 Ser Asp Gly Thr Val Thr Lys Gly Gly Tyr Ser Ser His Ile Leu Val 130 135 140 His Gln Arg Tyr Cys Phe Lys Ile Pro Ala Asp Tyr Pro Leu Ser Lys 145 150 155 160 Ala Ala Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Thr Pro Met Ile 165 170 175 Arg His Asn Met Asn Gln Pro Gly Lys Ser Leu Gly Val Ile Gly Leu 180 185 190 Gly Gly Leu Gly Pro Met Ala Val Lys Phe Gly Lys Ala Phe Gly Leu 195 200 205 Lys Val Thr Val Phe Ser Thr Ser Glu Ser Lys Arg Glu Glu Ala Ile 210 215 220 Asn Leu Leu Gly Ala Asp Asn Phe Val Ile Ser Ser Asp Glu Asn Gln 225 230 235 240 Met Glu Ser Leu Lys Ser Ser Leu His Phe Ile Ile Asp Thr Ala Ser 245 250 255 Gly Asp His Gln Phe Asp Pro Tyr Leu Ser Leu Leu Lys Val Gly Gly 260 265 270 Val Met Val Leu Leu Ser Phe Pro Ser Glu Ile Lys Val His Pro Glu 275 280 285 Asn Leu Asn Leu Ala Ala Arg Ser Leu Ala Gly Ser Val Thr Gly Gly 290 295 300 Thr Lys Asp Ile Gln Glu Met Ile Asn Phe Cys Ala Ala Asn Asn Val 305 310 315 320 Tyr Pro Asp Ile Glu Met Ile Lys Ile Asp Tyr Val Asn Glu Ala Leu 325 330 335 Gln Arg Leu Ile Asn Arg Asp Val Arg Phe Arg Phe Val Ile Asp Ile 340 345 350 Glu Asn Ser Phe Lys 355 <210> 502 <211> 450 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(450) <400> 502 atg gcc gat cag ctc acc gac gaa cag atc tcc gag ttc aag gaa gcc 48 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 ttc agc ctc ttc gac aag gac ggg gat ggt tgt att acc acc aag gaa 96 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 ctt ggg acc gtg atg cgg tca ctt ggc cag aac cca act gag gca gag 144 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 ctg cag gac atg ata aat gag gtt gat gct gat ggg aat ggt acc att 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 gat ttc cca gaa ttc ctg aat ctc atg gct cgc aag atg aaa gac act 240 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 gat tca gag gag gag ctg aag gag gct ttc cgc gtg ttt gac aag gat 288 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 cag aat ggc ttc atc tct gca gcg gag ctc cgc cat gtg atg acc aat 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 ctc ggt gag aag ctg acc gac gag gaa gtc gat gag atg att cgc gag 384 Page 577 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 gct gac gtt gat ggt gat ggt cag atc aac tat gag gag ttt gtc aaa 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 gtc atg atg gcc aag tga 450 Val Met Met Ala Lys 145 <210> 503 <211> 149 <212> PRT <213> Oryza sativa <400> 503 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Val Met Met Ala Lys 145 <210> 504 <211> 786 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(786) <400> 504 atg gcc gtc gga aag aac aag cgc atc tcc aag ggg aag aag ggt ggc 48 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Lys Lys Gly Gly 1 5 10 15 aag aag aag gca gct gat ccc ttt gcc aag aag gat tgg tat gac att 96 Lys Lys Lys Ala Ala Asp Pro Phe Ala Lys Lys Asp Trp Tyr Asp Ile 20 25 30 aag gct cct tct gtt ttt caa gtg aaa aat gtt ggc aaa acc ctc gtc 144 Lys Ala Pro Ser Val Phe Gln Val Lys Asn Val Gly Lys Thr Leu Val 35 40 45 tct cgt act cag ggt acc aag att gct tct gaa gga ctc aag cat aga 192 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 gtg ttt gag gtc tcc ttg gct gat ctt caa ggg gat gag gat cat gca 240 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ala 65 70 75 80 ttc aag aag att agg ttg aga gct gaa gat gtg caa ggg aag aat gtt 288 Phe Lys Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Lys Asn Val 85 90 95 ctg aca aat ttc tgg gga atg gat ttc aca aca gac aag ctg agg tca 336 Leu Thr Asn Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 ttg gta cga aaa tgg caa act ctt att gaa gcc cat gtg gat gtg aag 384 Page 578 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Val Arg Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 aca act gat aat tac aca ttg agg atg ttt tgc att gga ttt acc aag 432 Thr Thr Asp Asn Tyr Thr Leu Arg Met Phe Cys Ile Gly Phe Thr Lys 130 135 140 aga aga gct aac cag gtg aag aga acc tgt tat gca caa tca agc cag 480 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 att aga cag att cgt agg aag atg agg gag atc atg acc aac cag gca 528 Ile Arg Gln Ile Arg Arg Lys Met Arg Glu Ile Met Thr Asn Gln Ala 165 170 175 aca gca tgt gat ttg aag gag ttg gtc cgg aag ttt att cct gag att 576 Thr Ala Cys Asp Leu Lys Glu Leu Val Arg Lys Phe Ile Pro Glu Ile 180 185 190 att gga aaa gag atc gag aag gca aca tct agt att tac cct ctg cag 624 Ile Gly Lys Glu Ile Glu Lys Ala Thr Ser Ser Ile Tyr Pro Leu Gln 195 200 205 aat gtg ttt gtt cgt aaa gtc aag atc ctg aaa gct cct aag ttt gat 672 Asn Val Phe Val Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 ctt ggg aaa ctg atg gag gtt cat gga gat tac tcc gag gat gtt ggt 720 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Ser Glu Asp Val Gly 225 230 235 240 gca aag gta gac aga cct gct gat gaa ata gtg gca gag gaa ccc act 768 Ala Lys Val Asp Arg Pro Ala Asp Glu Ile Val Ala Glu Glu Pro Thr 245 250 255 gaa att gtt gga gct tga 786 Glu Ile Val Gly Ala 260 <210> 505 <211> 261 <212> PRT <213> Oryza sativa <400> 505 Met Ala Val Gly Lys Asn Lys Arg Ile Ser Lys Gly Lys Lys Gly Gly 1 5 10 15 Lys Lys Lys Ala Ala Asp Pro Phe Ala Lys Lys Asp Trp Tyr Asp Ile 20 25 30 Lys Ala Pro Ser Val Phe Gln Val Lys Asn Val Gly Lys Thr Leu Val 35 40 45 Ser Arg Thr Gln Gly Thr Lys Ile Ala Ser Glu Gly Leu Lys His Arg 50 55 60 Val Phe Glu Val Ser Leu Ala Asp Leu Gln Gly Asp Glu Asp His Ala 65 70 75 80 Phe Lys Lys Ile Arg Leu Arg Ala Glu Asp Val Gln Gly Lys Asn Val 85 90 95 Leu Thr Asn Phe Trp Gly Met Asp Phe Thr Thr Asp Lys Leu Arg Ser 100 105 110 Leu Val Arg Lys Trp Gln Thr Leu Ile Glu Ala His Val Asp Val Lys 115 120 125 Thr Thr Asp Asn Tyr Thr Leu Arg Met Phe Cys Ile Gly Phe Thr Lys 130 135 140 Arg Arg Ala Asn Gln Val Lys Arg Thr Cys Tyr Ala Gln Ser Ser Gln 145 150 155 160 Ile Arg Gln Ile Arg Arg Lys Met Arg Glu Ile Met Thr Asn Gln Ala 165 170 175 Thr Ala Cys Asp Leu Lys Glu Leu Val Arg Lys Phe Ile Pro Glu Ile 180 185 190 Ile Gly Lys Glu Ile Glu Lys Ala Thr Ser Ser Ile Tyr Pro Leu Gln 195 200 205 Asn Val Phe Val Arg Lys Val Lys Ile Leu Lys Ala Pro Lys Phe Asp 210 215 220 Leu Gly Lys Leu Met Glu Val His Gly Asp Tyr Ser Glu Asp Val Gly 225 230 235 240 Ala Lys Val Asp Arg Pro Ala Asp Glu Ile Val Ala Glu Glu Pro Thr 245 250 255 Page 579 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Glu Ile Val Gly Ala 260 <210> 506 <211> 702 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(702) <400> 506 atg gat cag aaa gtc gat ttc agt gct ccg cat tcc atg gga acc act 48 Met Asp Gln Lys Val Asp Phe Ser Ala Pro His Ser Met Gly Thr Thr 1 5 10 15 atc atc ggc gtt act tac aac ggc ggt gtc gtt ctc gga gcc gac tct 96 Ile Ile Gly Val Thr Tyr Asn Gly Gly Val Val Leu Gly Ala Asp Ser 20 25 30 cga acc agc act gga gtg tat gtt gcc aac cga gca tcg gac aaa atc 144 Arg Thr Ser Thr Gly Val Tyr Val Ala Asn Arg Ala Ser Asp Lys Ile 35 40 45 aca cag ctc act gat aat gtt tac gtg tgt cgc tct gga tcg gct gct 192 Thr Gln Leu Thr Asp Asn Val Tyr Val Cys Arg Ser Gly Ser Ala Ala 50 55 60 gat tct cag att gtc tct gac tat gtg cgc tac ttc ctt cac caa cac 240 Asp Ser Gln Ile Val Ser Asp Tyr Val Arg Tyr Phe Leu His Gln His 65 70 75 80 acg ata caa ctt gga caa cct gcg aca gtt aaa gtt gct gca aac ctt 288 Thr Ile Gln Leu Gly Gln Pro Ala Thr Val Lys Val Ala Ala Asn Leu 85 90 95 gtc cgg ctt ctc gca tat aac aat aag aat ttc tta cag acc ggg tta 336 Val Arg Leu Leu Ala Tyr Asn Asn Lys Asn Phe Leu Gln Thr Gly Leu 100 105 110 att gtt ggt ggt tgg gat aaa tat gaa ggt gga caa att tat gga gtt 384 Ile Val Gly Gly Trp Asp Lys Tyr Glu Gly Gly Gln Ile Tyr Gly Val 115 120 125 cct ctg ggt gga aca ata gta cag caa cct ttt gct atc gga gga tct 432 Pro Leu Gly Gly Thr Ile Val Gln Gln Pro Phe Ala Ile Gly Gly Ser 130 135 140 ggg tcc agt tac ttg tat ggt ttc ttt gac caa gcc tgg aaa gag gga 480 Gly Ser Ser Tyr Leu Tyr Gly Phe Phe Asp Gln Ala Trp Lys Glu Gly 145 150 155 160 atg acc aag gat gaa gcc gag gat tta gta aaa aag gca gtt tca ctg 528 Met Thr Lys Asp Glu Ala Glu Asp Leu Val Lys Lys Ala Val Ser Leu 165 170 175 gct att gct cgt gat ggt gca agt ggt ggg gtg gtg cga aca gtc ata 576 Ala Ile Ala Arg Asp Gly Ala Ser Gly Gly Val Val Arg Thr Val Ile 180 185 190 ata aac tca gag gga gtg acc agg aat ttc tac cct ggc gac caa ctt 624 Ile Asn Ser Glu Gly Val Thr Arg Asn Phe Tyr Pro Gly Asp Gln Leu 195 200 205 cca tta tgg cat gag gaa atg gag gcc cac aac tct ctg cta gac att 672 Pro Leu Trp His Glu Glu Met Glu Ala His Asn Ser Leu Leu Asp Ile 210 215 220 ctt ggt gtc cca gag ccg atg agc atg tga 702 Leu Gly Val Pro Glu Pro Met Ser Met 225 230 <210> 507 <211> 233 <212> PRT <213> Oryza sativa <400> 507 Met Asp Gln Lys Val Asp Phe Ser Ala Pro His Ser Met Gly Thr Thr 1 5 10 15 Ile Ile Gly Val Thr Tyr Asn Gly Gly Val Val Leu Gly Ala Asp Ser Page 580 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 Arg Thr Ser Thr Gly Val Tyr Val Ala Asn Arg Ala Ser Asp Lys Ile 35 40 45 Thr Gln Leu Thr Asp Asn Val Tyr Val Cys Arg Ser Gly Ser Ala Ala 50 55 60 Asp Ser Gln Ile Val Ser Asp Tyr Val Arg Tyr Phe Leu His Gln His 65 70 75 80 Thr Ile Gln Leu Gly Gln Pro Ala Thr Val Lys Val Ala Ala Asn Leu 85 90 95 Val Arg Leu Leu Ala Tyr Asn Asn Lys Asn Phe Leu Gln Thr Gly Leu 100 105 110 Ile Val Gly Gly Trp Asp Lys Tyr Glu Gly Gly Gln Ile Tyr Gly Val 115 120 125 Pro Leu Gly Gly Thr Ile Val Gln Gln Pro Phe Ala Ile Gly Gly Ser 130 135 140 Gly Ser Ser Tyr Leu Tyr Gly Phe Phe Asp Gln Ala Trp Lys Glu Gly 145 150 155 160 Met Thr Lys Asp Glu Ala Glu Asp Leu Val Lys Lys Ala Val Ser Leu 165 170 175 Ala Ile Ala Arg Asp Gly Ala Ser Gly Gly Val Val Arg Thr Val Ile 180 185 190 Ile Asn Ser Glu Gly Val Thr Arg Asn Phe Tyr Pro Gly Asp Gln Leu 195 200 205 Pro Leu Trp His Glu Glu Met Glu Ala His Asn Ser Leu Leu Asp Ile 210 215 220 Leu Gly Val Pro Glu Pro Met Ser Met 225 230 <210> 508 <211> 348 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(348) <400> 508 atg tct gat ctc gac gtt cag ctt cca tct gcc ttc gat ccg ttt gct 48 Met Ser Asp Leu Asp Val Gln Leu Pro Ser Ala Phe Asp Pro Phe Ala 1 5 10 15 gag gca aat gct gag gac tcc ggc gct ggc cct gga gca aag gat tat 96 Glu Ala Asn Ala Glu Asp Ser Gly Ala Gly Pro Gly Ala Lys Asp Tyr 20 25 30 gtg cat gtg cgc atc cag cag cgc aac ggc aga aag agt cta act act 144 Val His Val Arg Ile Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 gtt cag ggc tta aag aag gag tac agt tac aac aag atc ctc aag gat 192 Val Gln Gly Leu Lys Lys Glu Tyr Ser Tyr Asn Lys Ile Leu Lys Asp 50 55 60 ctg aaa aag gag ttc tgc tgc aat ggt act gta gtc caa gat cca gag 240 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu 65 70 75 80 ctt ggc cag gtc att cag ctt caa ggt gat cag cgt aag aat gtt gcc 288 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ala 85 90 95 acg ttc cta gtt cag gct ggg att gct aag aag gac aac atc aag att 336 Thr Phe Leu Val Gln Ala Gly Ile Ala Lys Lys Asp Asn Ile Lys Ile 100 105 110 cac ggt ttc taa 348 His Gly Phe 115 <210> 509 <211> 115 <212> PRT <213> Oryza sativa Page 581 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 509 Met Ser Asp Leu Asp Val Gln Leu Pro Ser Ala Phe Asp Pro Phe Ala 1 5 10 15 Glu Ala Asn Ala Glu Asp Ser Gly Ala Gly Pro Gly Ala Lys Asp Tyr 20 25 30 Val His Val Arg Ile Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 Val Gln Gly Leu Lys Lys Glu Tyr Ser Tyr Asn Lys Ile Leu Lys Asp 50 55 60 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu 65 70 75 80 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ala 85 90 95 Thr Phe Leu Val Gln Ala Gly Ile Ala Lys Lys Asp Asn Ile Lys Ile 100 105 110 His Gly Phe 115 <210> 510 <211> 411 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(411) <400> 510 atg gct cgt acc aag caa acc gct cgc aaa tcc acc ggt gga aag gct 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 cct agg aag caa ctc gcc acc aag gct gca agg aaa tct gca ccg aca 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 acc ggt gga gtc aag aag cct cat cgc tat cgc cct gga act gtt gct 144 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 ctt cgt gag atc cga aaa tac caa aag agc aca gag ctt ctg atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctc ccc ttc cag cgt ctt gtt cgt gaa att gcg caa gac ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acc gat ttg agg ttc cag agt cac gct gtt ctt gcg ctt cag gaa gct 288 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 gcg gag gct tac ttg gtg ggt ttg ttt gag gac acc aac ttg tgt gcg 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cac gcc aag agg gtg acc atc atg cca aag gac att caa ctc gca 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 cgc cgc atc cgt gga gaa cgt gct tag 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 511 <211> 136 <212> PRT <213> Oryza sativa <400> 511 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 Page 582 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 512 <211> 816 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(816) <400> 512 atg tct cct tcg ttg gat ctt cct ccc aag ggt ggc ttc agt ttt gat 48 Met Ser Pro Ser Leu Asp Leu Pro Pro Lys Gly Gly Phe Ser Phe Asp 1 5 10 15 cta tgc cga aga aac gca atg ctt caa aac aag ggc ctc aaa gcc cca 96 Leu Cys Arg Arg Asn Ala Met Leu Gln Asn Lys Gly Leu Lys Ala Pro 20 25 30 acc ttt ctc aaa act ggc acc act att gtc ggt tta gtt ttc cag gat 144 Thr Phe Leu Lys Thr Gly Thr Thr Ile Val Gly Leu Val Phe Gln Asp 35 40 45 ggt gtc att ctt ggt gct gat act agg gca act gaa gga cct ata gtg 192 Gly Val Ile Leu Gly Ala Asp Thr Arg Ala Thr Glu Gly Pro Ile Val 50 55 60 gct gat aaa aac tgt gag aaa att cat tat atg gca ccc aac ata tat 240 Ala Asp Lys Asn Cys Glu Lys Ile His Tyr Met Ala Pro Asn Ile Tyr 65 70 75 80 tgc tgt gga gca ggc aca gct gct gat aca gag gct gta aca gac atg 288 Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Glu Ala Val Thr Asp Met 85 90 95 gtt agc tca cag ctg caa tta cat cgc tac cat act ggt cga gaa tca 336 Val Ser Ser Gln Leu Gln Leu His Arg Tyr His Thr Gly Arg Glu Ser 100 105 110 aga gtt gtt aca gcg ctg acc ctt ctt aag aaa cac ctt ttc aat tat 384 Arg Val Val Thr Ala Leu Thr Leu Leu Lys Lys His Leu Phe Asn Tyr 115 120 125 caa ggg cat gtc tca gct gct ttg gtg ctt ggt ggg gtt gat atc act 432 Gln Gly His Val Ser Ala Ala Leu Val Leu Gly Gly Val Asp Ile Thr 130 135 140 gga cct cat ttg cat act att tat cct cat ggg tca act gac acc ctc 480 Gly Pro His Leu His Thr Ile Tyr Pro His Gly Ser Thr Asp Thr Leu 145 150 155 160 cca ttt gct aca atg gga tca ggt tca ctt gct gca atg tct gta ttt 528 Pro Phe Ala Thr Met Gly Ser Gly Ser Leu Ala Ala Met Ser Val Phe 165 170 175 gag tcc aag tac aag gaa agt ttg agt agg gat gaa ggc att aag cta 576 Glu Ser Lys Tyr Lys Glu Ser Leu Ser Arg Asp Glu Gly Ile Lys Leu 180 185 190 gtt gtt gag gcg ata tgc gct gga ata ttt aat gac cta gga agt gga 624 Val Val Glu Ala Ile Cys Ala Gly Ile Phe Asn Asp Leu Gly Ser Gly 195 200 205 agt aat gtt gac gtt tgt gtg ata acc aag gga cac aag gaa tat ctc 672 Ser Asn Val Asp Val Cys Val Ile Thr Lys Gly His Lys Glu Tyr Leu 210 215 220 agg aac cac ctt cta cca aat cct cgt acc tat gtc aat cca aaa ggc 720 Arg Asn His Leu Leu Pro Asn Pro Arg Thr Tyr Val Asn Pro Lys Gly 225 230 235 240 Page 583 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttt gat ttc ccc aaa aag aca gag gtc ctc tta aca aag att acc ccg 768 Phe Asp Phe Pro Lys Lys Thr Glu Val Leu Leu Thr Lys Ile Thr Pro 245 250 255 ttg aag gag aag gtg gaa gtg att gaa gga gat gct atg gaa gag 813 Leu Lys Glu Lys Val Glu Val Ile Glu Gly Asp Ala Met Glu Glu 260 265 270 taa 816 <210> 513 <211> 271 <212> PRT <213> Oryza sativa <400> 513 Met Ser Pro Ser Leu Asp Leu Pro Pro Lys Gly Gly Phe Ser Phe Asp 1 5 10 15 Leu Cys Arg Arg Asn Ala Met Leu Gln Asn Lys Gly Leu Lys Ala Pro 20 25 30 Thr Phe Leu Lys Thr Gly Thr Thr Ile Val Gly Leu Val Phe Gln Asp 35 40 45 Gly Val Ile Leu Gly Ala Asp Thr Arg Ala Thr Glu Gly Pro Ile Val 50 55 60 Ala Asp Lys Asn Cys Glu Lys Ile His Tyr Met Ala Pro Asn Ile Tyr 65 70 75 80 Cys Cys Gly Ala Gly Thr Ala Ala Asp Thr Glu Ala Val Thr Asp Met 85 90 95 Val Ser Ser Gln Leu Gln Leu His Arg Tyr His Thr Gly Arg Glu Ser 100 105 110 Arg Val Val Thr Ala Leu Thr Leu Leu Lys Lys His Leu Phe Asn Tyr 115 120 125 Gln Gly His Val Ser Ala Ala Leu Val Leu Gly Gly Val Asp Ile Thr 130 135 140 Gly Pro His Leu His Thr Ile Tyr Pro His Gly Ser Thr Asp Thr Leu 145 150 155 160 Pro Phe Ala Thr Met Gly Ser Gly Ser Leu Ala Ala Met Ser Val Phe 165 170 175 Glu Ser Lys Tyr Lys Glu Ser Leu Ser Arg Asp Glu Gly Ile Lys Leu 180 185 190 Val Val Glu Ala Ile Cys Ala Gly Ile Phe Asn Asp Leu Gly Ser Gly 195 200 205 Ser Asn Val Asp Val Cys Val Ile Thr Lys Gly His Lys Glu Tyr Leu 210 215 220 Arg Asn His Leu Leu Pro Asn Pro Arg Thr Tyr Val Asn Pro Lys Gly 225 230 235 240 Phe Asp Phe Pro Lys Lys Thr Glu Val Leu Leu Thr Lys Ile Thr Pro 245 250 255 Leu Lys Glu Lys Val Glu Val Ile Glu Gly Asp Ala Met Glu Glu 260 265 270 <210> 514 <211> 450 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(450) <400> 514 atg gcc gat caa ctt acc gat gaa cag atc tcc gag ttc aag gaa gcc 48 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 ttc agc ttg ttc gac aag gac ggc gat ggt tgc atc aca acc aag gag 96 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 ctt gga act gtt atg cgt tca ttg ggg caa aac cca act gag gca gag 144 Page 584 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 ctc cag gac atg atc aat gaa gtg gat gct gat ggg aat ggt acc att 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 gac ttc cct gag ttc cta aat ctc atg gcc agg aag atg aag gac act 240 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 gat tct gag gag gag ctg aaa gag gca ttc cgg gtt ttc gac aag gac 288 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 cag aat ggg ttc atc tct gct gct gag ctc cgc cat gtg atg acc aac 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 ctc ggg gag aag ctc acc gat gaa gag gtt gat gag atg att cgc gag 384 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 gcc gat gtt gat ggc gat ggc caa ata aac tac gag gag ttc gtt aag 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 gtg atg atg gcc aag tga 450 Val Met Met Ala Lys 145 <210> 515 <211> 149 <212> PRT <213> Oryza sativa <400> 515 Met Ala Asp Gln Leu Thr Asp Glu Gln Ile Ser Glu Phe Lys Glu Ala 1 5 10 15 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Val Met Met Ala Lys 145 <210> 516 <211> 501 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(501) <400> 516 atg aag aat gca aag ggc aag gga gca gca agg gcc tca aaa gaa tca 48 Met Lys Asn Ala Lys Gly Lys Gly Ala Ala Arg Ala Ser Lys Glu Ser 1 5 10 15 ctg aag ccc gtt gat gac cga aag gtt gga aag cgg aag gct tcc ggt 96 Leu Lys Pro Val Asp Asp Arg Lys Val Gly Lys Arg Lys Ala Ser Gly 20 25 30 aag cct ggg aga agt agt gca cca aag aag gag aag aag gcc aag aaa 144 Page 585 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Lys Pro Gly Arg Ser Ser Ala Pro Lys Lys Glu Lys Lys Ala Lys Lys 35 40 45 gac ccc aac aag cct aaa aga cca ccc agt gct ttc ttt gtg ttc ctt 192 Asp Pro Asn Lys Pro Lys Arg Pro Pro Ser Ala Phe Phe Val Phe Leu 50 55 60 gag gag ttc agg aag acc ttt aag gct gag aat cct aat gtg aag gct 240 Glu Glu Phe Arg Lys Thr Phe Lys Ala Glu Asn Pro Asn Val Lys Ala 65 70 75 80 gta tca gtt gtt ggg aaa gct gga gga gag aaa tgg aaa tcc ttg tcc 288 Val Ser Val Val Gly Lys Ala Gly Gly Glu Lys Trp Lys Ser Leu Ser 85 90 95 agt gct gag aaa gct cca tat gaa gcc aag gct gcg aaa agg aaa gct 336 Ser Ala Glu Lys Ala Pro Tyr Glu Ala Lys Ala Ala Lys Arg Lys Ala 100 105 110 gag tat gaa aaa ctt atc aaa gct tat gat aaa aag cag gca agc tcc 384 Glu Tyr Glu Lys Leu Ile Lys Ala Tyr Asp Lys Lys Gln Ala Ser Ser 115 120 125 gca gat gat gaa gaa tca gac aag tcc aaa tct gaa gtg aat gat gaa 432 Ala Asp Asp Glu Glu Ser Asp Lys Ser Lys Ser Glu Val Asn Asp Glu 130 135 140 gat gat gcc agt gga gag gag gag gaa gag gat gat gag gag gaa gag 480 Asp Asp Ala Ser Gly Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu 145 150 155 160 gac gat gaa gat gat gac tga 501 Asp Asp Glu Asp Asp Asp 165 <210> 517 <211> 166 <212> PRT <213> Oryza sativa <400> 517 Met Lys Asn Ala Lys Gly Lys Gly Ala Ala Arg Ala Ser Lys Glu Ser 1 5 10 15 Leu Lys Pro Val Asp Asp Arg Lys Val Gly Lys Arg Lys Ala Ser Gly 20 25 30 Lys Pro Gly Arg Ser Ser Ala Pro Lys Lys Glu Lys Lys Ala Lys Lys 35 40 45 Asp Pro Asn Lys Pro Lys Arg Pro Pro Ser Ala Phe Phe Val Phe Leu 50 55 60 Glu Glu Phe Arg Lys Thr Phe Lys Ala Glu Asn Pro Asn Val Lys Ala 65 70 75 80 Val Ser Val Val Gly Lys Ala Gly Gly Glu Lys Trp Lys Ser Leu Ser 85 90 95 Ser Ala Glu Lys Ala Pro Tyr Glu Ala Lys Ala Ala Lys Arg Lys Ala 100 105 110 Glu Tyr Glu Lys Leu Ile Lys Ala Tyr Asp Lys Lys Gln Ala Ser Ser 115 120 125 Ala Asp Asp Glu Glu Ser Asp Lys Ser Lys Ser Glu Val Asn Asp Glu 130 135 140 Asp Asp Ala Ser Gly Glu Glu Glu Glu Glu Asp Asp Glu Glu Glu Glu 145 150 155 160 Asp Asp Glu Asp Asp Asp 165 <210> 518 <211> 1038 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(1038) <400> 518 atg ccg gcg gcg gcg gcg gcg aag acg ctg gtg cca gcc cgc ggc ggc 48 Met Pro Ala Ala Ala Ala Ala Lys Thr Leu Val Pro Ala Arg Gly Gly Page 586 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 1 5 10 15 ggc gac atg gag gag ccg ctg ctg gcg gag tcg tcg gat cgc ttc tcg 96 Gly Asp Met Glu Glu Pro Leu Leu Ala Glu Ser Ser Asp Arg Phe Ser 20 25 30 atg ttc ccg atc agg tac ccg cag atc tgg gag ttc tac aag aag gcg 144 Met Phe Pro Ile Arg Tyr Pro Gln Ile Trp Glu Phe Tyr Lys Lys Ala 35 40 45 gtg gcg tcg ttc tgg acg gcg gag gag gtg gac ctc tcc gcc gac gcg 192 Val Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Ala Asp Ala 50 55 60 cgc cac tgg gac gcc gcg ctg tcg ccc gac gag cgc cac ttc gtc tcc 240 Arg His Trp Asp Ala Ala Leu Ser Pro Asp Glu Arg His Phe Val Ser 65 70 75 80 cac gtg ctc gcc ttc ttc gcg gcc tcc gat ggc atc gtg ctc gag aac 288 His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu Asn 85 90 95 ctc gcc tcc agg ttc atg tcc gac gtg cag gtc gcc gag gct cgc gcc 336 Leu Ala Ser Arg Phe Met Ser Asp Val Gln Val Ala Glu Ala Arg Ala 100 105 110 ttc tac ggc ttc cag atc gcc atc gag aac atc cac tcg gag atg tac 384 Phe Tyr Gly Phe Gln Ile Ala Ile Glu Asn Ile His Ser Glu Met Tyr 115 120 125 tcg ctt ctg ctc gag acg tac atc cgc gac gac gtc gag aag gac cgc 432 Ser Leu Leu Leu Glu Thr Tyr Ile Arg Asp Asp Val Glu Lys Asp Arg 130 135 140 ctc ttc cgc gcc atc gac acc gtc ccc gcc gtg cgc cgc aag gcc gac 480 Leu Phe Arg Ala Ile Asp Thr Val Pro Ala Val Arg Arg Lys Ala Asp 145 150 155 160 tgg gcc atg cga tgg atc gac ggc ggc gag cgc ttc gcc gag cgg ctc 528 Trp Ala Met Arg Trp Ile Asp Gly Gly Glu Arg Phe Ala Glu Arg Leu 165 170 175 gtc gcc ttc gcc tgc gtc gag ggg atc ttc ttc tcg ggt tca ttc tgc 576 Val Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe Cys 180 185 190 gcc atc ttc tgg ctc aag aag cgc gga ctc atg ccg ggc ctc acc ttc 624 Ala Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr Phe 195 200 205 tcc aac gag ctc atc tcc cgc gac gag ggt ctc cac tgc gac ttc gcc 672 Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe Ala 210 215 220 tgc ctc ctc tac gac ctc ctc cgc ggc aag ctc gac gag tca cgc gtc 720 Cys Leu Leu Tyr Asp Leu Leu Arg Gly Lys Leu Asp Glu Ser Arg Val 225 230 235 240 cag gag atc gtc gcc gac gcc gtg gac atc gag agg gag ttc gtc tgc 768 Gln Glu Ile Val Ala Asp Ala Val Asp Ile Glu Arg Glu Phe Val Cys 245 250 255 gac gcg ctc ccc gtc gcg ctc gtc ggg atg aac ggc gag ctc atg agc 816 Asp Ala Leu Pro Val Ala Leu Val Gly Met Asn Gly Glu Leu Met Ser 260 265 270 cag tac atc gag ttc gtc gcc gac cgg ctg ctc atg gcg ctc ggg tgc 864 Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Leu Met Ala Leu Gly Cys 275 280 285 aag aag atg tac aac gtc gcc aac ccg ttc gac tgg atg gag ctc atc 912 Lys Lys Met Tyr Asn Val Ala Asn Pro Phe Asp Trp Met Glu Leu Ile 290 295 300 tcc ctg cag ggc aag acc aac ttc ttc gag aag cgc gtc ggc gac tac 960 Ser Leu Gln Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Asp Tyr 305 310 315 320 cag aag gcg tcc gta atg tcc agc ctc aac ggc ggc gct tct tgc aac 1008 Gln Lys Ala Ser Val Met Ser Ser Leu Asn Gly Gly Ala Ser Cys Asn 325 330 335 cat gtc ttc agc atc gac gag gac ttc tga 1038 His Val Phe Ser Ile Asp Glu Asp Phe 340 345 <210> 519 <211> 345 <212> PRT Page 587 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Oryza sativa <400> 519 Met Pro Ala Ala Ala Ala Ala Lys Thr Leu Val Pro Ala Arg Gly Gly 1 5 10 15 Gly Asp Met Glu Glu Pro Leu Leu Ala Glu Ser Ser Asp Arg Phe Ser 20 25 30 Met Phe Pro Ile Arg Tyr Pro Gln Ile Trp Glu Phe Tyr Lys Lys Ala 35 40 45 Val Ala Ser Phe Trp Thr Ala Glu Glu Val Asp Leu Ser Ala Asp Ala 50 55 60 Arg His Trp Asp Ala Ala Leu Ser Pro Asp Glu Arg His Phe Val Ser 65 70 75 80 His Val Leu Ala Phe Phe Ala Ala Ser Asp Gly Ile Val Leu Glu Asn 85 90 95 Leu Ala Ser Arg Phe Met Ser Asp Val Gln Val Ala Glu Ala Arg Ala 100 105 110 Phe Tyr Gly Phe Gln Ile Ala Ile Glu Asn Ile His Ser Glu Met Tyr 115 120 125 Ser Leu Leu Leu Glu Thr Tyr Ile Arg Asp Asp Val Glu Lys Asp Arg 130 135 140 Leu Phe Arg Ala Ile Asp Thr Val Pro Ala Val Arg Arg Lys Ala Asp 145 150 155 160 Trp Ala Met Arg Trp Ile Asp Gly Gly Glu Arg Phe Ala Glu Arg Leu 165 170 175 Val Ala Phe Ala Cys Val Glu Gly Ile Phe Phe Ser Gly Ser Phe Cys 180 185 190 Ala Ile Phe Trp Leu Lys Lys Arg Gly Leu Met Pro Gly Leu Thr Phe 195 200 205 Ser Asn Glu Leu Ile Ser Arg Asp Glu Gly Leu His Cys Asp Phe Ala 210 215 220 Cys Leu Leu Tyr Asp Leu Leu Arg Gly Lys Leu Asp Glu Ser Arg Val 225 230 235 240 Gln Glu Ile Val Ala Asp Ala Val Asp Ile Glu Arg Glu Phe Val Cys 245 250 255 Asp Ala Leu Pro Val Ala Leu Val Gly Met Asn Gly Glu Leu Met Ser 260 265 270 Gln Tyr Ile Glu Phe Val Ala Asp Arg Leu Leu Met Ala Leu Gly Cys 275 280 285 Lys Lys Met Tyr Asn Val Ala Asn Pro Phe Asp Trp Met Glu Leu Ile 290 295 300 Ser Leu Gln Gly Lys Thr Asn Phe Phe Glu Lys Arg Val Gly Asp Tyr 305 310 315 320 Gln Lys Ala Ser Val Met Ser Ser Leu Asn Gly Gly Ala Ser Cys Asn 325 330 335 His Val Phe Ser Ile Asp Glu Asp Phe 340 345 <210> 520 <211> 486 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(486) <400> 520 atg atc aac ttt gtg ctt ctc att agt cgc caa ggg aag gtg aga ttg 48 Met Ile Asn Phe Val Leu Leu Ile Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 aca aaa tgg tac tca cct tat tct cag aaa gaa agg agt aag gta atc 96 Thr Lys Trp Tyr Ser Pro Tyr Ser Gln Lys Glu Arg Ser Lys Val Ile 20 25 30 cgt gag ctc agt gga atg att ctt tcc cgt gcg ccc aag caa tgt aat 144 Arg Glu Leu Ser Gly Met Ile Leu Ser Arg Ala Pro Lys Gln Cys Asn 35 40 45 ttt gtg gaa tgg cga gga cat aaa gtt gtt tat aaa agg tat gct agt 192 Page 588 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Phe Val Glu Trp Arg Gly His Lys Val Val Tyr Lys Arg Tyr Ala Ser 50 55 60 ctc tat ttc tgc atg tgc att gat caa gat gac aat gaa tta gaa gtc 240 Leu Tyr Phe Cys Met Cys Ile Asp Gln Asp Asp Asn Glu Leu Glu Val 65 70 75 80 ctt gaa atg att cat cat ttt gtg gag att ctt gac cgg tat ttt ggc 288 Leu Glu Met Ile His His Phe Val Glu Ile Leu Asp Arg Tyr Phe Gly 85 90 95 agt gtc tgt gaa ctg gac tta ata ttc aac ttt cac aag gcc tac tat 336 Ser Val Cys Glu Leu Asp Leu Ile Phe Asn Phe His Lys Ala Tyr Tyr 100 105 110 ata cta gat gaa att cta att gcc ggt gag ctt caa gag tcc agc aag 384 Ile Leu Asp Glu Ile Leu Ile Ala Gly Glu Leu Gln Glu Ser Ser Lys 115 120 125 aaa aca gtt gcc cga ttg ata gca gca cag gat tcg ttg gtg gag aat 432 Lys Thr Val Ala Arg Leu Ile Ala Ala Gln Asp Ser Leu Val Glu Asn 130 135 140 gca aag gaa gaa gcc agt tcg ttt agt aat ata att gca caa gcc act 480 Ala Lys Glu Glu Ala Ser Ser Phe Ser Asn Ile Ile Ala Gln Ala Thr 145 150 155 160 aag tga 486 Lys <210> 521 <211> 161 <212> PRT <213> Oryza sativa <400> 521 Met Ile Asn Phe Val Leu Leu Ile Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 Thr Lys Trp Tyr Ser Pro Tyr Ser Gln Lys Glu Arg Ser Lys Val Ile 20 25 30 Arg Glu Leu Ser Gly Met Ile Leu Ser Arg Ala Pro Lys Gln Cys Asn 35 40 45 Phe Val Glu Trp Arg Gly His Lys Val Val Tyr Lys Arg Tyr Ala Ser 50 55 60 Leu Tyr Phe Cys Met Cys Ile Asp Gln Asp Asp Asn Glu Leu Glu Val 65 70 75 80 Leu Glu Met Ile His His Phe Val Glu Ile Leu Asp Arg Tyr Phe Gly 85 90 95 Ser Val Cys Glu Leu Asp Leu Ile Phe Asn Phe His Lys Ala Tyr Tyr 100 105 110 Ile Leu Asp Glu Ile Leu Ile Ala Gly Glu Leu Gln Glu Ser Ser Lys 115 120 125 Lys Thr Val Ala Arg Leu Ile Ala Ala Gln Asp Ser Leu Val Glu Asn 130 135 140 Ala Lys Glu Glu Ala Ser Ser Phe Ser Asn Ile Ile Ala Gln Ala Thr 145 150 155 160 Lys <210> 522 <211> 615 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(615) <400> 522 atg gga gcg tac cgt tat atg caa gaa ttg tat cgc aag aag cag agc 48 Met Gly Ala Tyr Arg Tyr Met Gln Glu Leu Tyr Arg Lys Lys Gln Ser 1 5 10 15 gat gta ctg aga tat ttg ctt cgt atc cga gta tgg caa tac cgt caa 96 Asp Val Leu Arg Tyr Leu Leu Arg Ile Arg Val Trp Gln Tyr Arg Gln Page 589 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 20 25 30 ctc aca aag atg gtt cgt tca ccg cga cca tcg cgt ccg gac aag gcc 144 Leu Thr Lys Met Val Arg Ser Pro Arg Pro Ser Arg Pro Asp Lys Ala 35 40 45 cgt cgc ttg gga ttc cgt gcc aag caa ggc tac gtc atc tac aga att 192 Arg Arg Leu Gly Phe Arg Ala Lys Gln Gly Tyr Val Ile Tyr Arg Ile 50 55 60 cgc gta cgc cgt gga ggt cgc aag cgt cca gtg cca aag ggt tgc acc 240 Arg Val Arg Arg Gly Gly Arg Lys Arg Pro Val Pro Lys Gly Cys Thr 65 70 75 80 tac ggc aaa cca aaa agc cac ggt gtc aac gaa ttg aaa cca aca cgc 288 Tyr Gly Lys Pro Lys Ser His Gly Val Asn Glu Leu Lys Pro Thr Arg 85 90 95 cga ttg caa tcg gtt gcc gag gaa cgc gtt ggt cgt cgt ctc gga gga 336 Arg Leu Gln Ser Val Ala Glu Glu Arg Val Gly Arg Arg Leu Gly Gly 100 105 110 ctt cgc gta ctc aac tcc tac tgg gtg gcc caa gat tcc tca tac aaa 384 Leu Arg Val Leu Asn Ser Tyr Trp Val Ala Gln Asp Ser Ser Tyr Lys 115 120 125 tat ttc gaa gtg att ttg gtt gat cca tca cac aat gct atc cgt cgc 432 Tyr Phe Glu Val Ile Leu Val Asp Pro Ser His Asn Ala Ile Arg Arg 130 135 140 gat cca aag att aac tgg atc tgc aag gct gtc atg aaa cat cgt gaa 480 Asp Pro Lys Ile Asn Trp Ile Cys Lys Ala Val Met Lys His Arg Glu 145 150 155 160 atg cgt ggc ctt aca tca gcc ggc aag agt tcg cgt ggc gtc gga aag 528 Met Arg Gly Leu Thr Ser Ala Gly Lys Ser Ser Arg Gly Val Gly Lys 165 170 175 gga tac aga tat tca caa aca atc ggt gga tct cga cgt gct gcc tgg 576 Gly Tyr Arg Tyr Ser Gln Thr Ile Gly Gly Ser Arg Arg Ala Ala Trp 180 185 190 aag cgc aag aac cgt ttg cat tta cgc aga aag cga tag 615 Lys Arg Lys Asn Arg Leu His Leu Arg Arg Lys Arg 195 200 <210> 523 <211> 204 <212> PRT <213> Oryza sativa <400> 523 Met Gly Ala Tyr Arg Tyr Met Gln Glu Leu Tyr Arg Lys Lys Gln Ser 1 5 10 15 Asp Val Leu Arg Tyr Leu Leu Arg Ile Arg Val Trp Gln Tyr Arg Gln 20 25 30 Leu Thr Lys Met Val Arg Ser Pro Arg Pro Ser Arg Pro Asp Lys Ala 35 40 45 Arg Arg Leu Gly Phe Arg Ala Lys Gln Gly Tyr Val Ile Tyr Arg Ile 50 55 60 Arg Val Arg Arg Gly Gly Arg Lys Arg Pro Val Pro Lys Gly Cys Thr 65 70 75 80 Tyr Gly Lys Pro Lys Ser His Gly Val Asn Glu Leu Lys Pro Thr Arg 85 90 95 Arg Leu Gln Ser Val Ala Glu Glu Arg Val Gly Arg Arg Leu Gly Gly 100 105 110 Leu Arg Val Leu Asn Ser Tyr Trp Val Ala Gln Asp Ser Ser Tyr Lys 115 120 125 Tyr Phe Glu Val Ile Leu Val Asp Pro Ser His Asn Ala Ile Arg Arg 130 135 140 Asp Pro Lys Ile Asn Trp Ile Cys Lys Ala Val Met Lys His Arg Glu 145 150 155 160 Met Arg Gly Leu Thr Ser Ala Gly Lys Ser Ser Arg Gly Val Gly Lys 165 170 175 Gly Tyr Arg Tyr Ser Gln Thr Ile Gly Gly Ser Arg Arg Ala Ala Trp 180 185 190 Lys Arg Lys Asn Arg Leu His Leu Arg Arg Lys Arg 195 200 Page 590 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 524 <211> 498 <212> DNA <213> Oryza sativa <400> 524 atggctcgca cgaagcaccc ggcggtgagg aagtcgaagg cggagcccaa gaagaagctc 60 cagttcgaac gctcccctcg gccgtcgaag gcgcagcgcg ctggtggcgg cacgggtacc 120 tcggcgacca cgaggagcgc ggctggaaca tcggcttcag cagggacgcc taggcagcaa 180 acgaagcaga ggaagccaca ccgcttccgt ccaggcacag tggcactgcg ggagatcagg 240 aaatttcaga aaaccaccga actgctgatc ccgtttgcac cattttctcg gctggtcagg 300 gagatcactg atttctattc aaaggatgtg tcacggtgga cccttgaagc tctccttgca 360 ttgcaagagg cagcagaata ccacttagtg gacatatttg aagtgtcaaa tctctgcgcc 420 atccatgcta agcgtgttac catcatgcaa aaggacatgc aacttgccag gcgtatcggt 480 gggcggaggc catggtga 498 <210> 525 <211> 543 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(543) <400> 525 atg ggt tgg atc ggt gag act gtt gat tcc atc aaa tct ctt cag atc 48 Met Gly Trp Ile Gly Glu Thr Val Asp Ser Ile Lys Ser Leu Gln Ile 1 5 10 15 cgc cag gtc ctc acc cag gct gtg agc cta ggc atg att gtt acg tct 96 Arg Gln Val Leu Thr Gln Ala Val Ser Leu Gly Met Ile Val Thr Ser 20 25 30 gca ctg ata ata tgg aag gca ttg atg tgc gtt act ggc agt gaa tct 144 Ala Leu Ile Ile Trp Lys Ala Leu Met Cys Val Thr Gly Ser Glu Ser 35 40 45 ccc gtt gtt gtt gtt ctt tct gga agc atg gaa ccc gga ttc aag cgg 192 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 gga gac atc ttg ttc ttg cac atg agt aaa gat cct att cgg gca ggg 240 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Ala Gly 65 70 75 80 gag att gtt gtg ttt aat gtt gat gga cgt gag att cca att gtt cat 288 Glu Ile Val Val Phe Asn Val Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 cgt gta att aag gta cat gaa agg gaa gat act ggg gag gtt gat gtt 336 Arg Val Ile Lys Val His Glu Arg Glu Asp Thr Gly Glu Val Asp Val 100 105 110 ctc aca aaa gga gac aac aat tat ggg gat gac agg cta ctg tat gct 384 Leu Thr Lys Gly Asp Asn Asn Tyr Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 cat ggt caa ctt tgg ctg caa agg cac cac att atg ggt aga gcc gtc 432 His Gly Gln Leu Trp Leu Gln Arg His His Ile Met Gly Arg Ala Val 130 135 140 ggg ttc tta cca tac gta ggc tgg gtg acc atc att atg act gaa aag 480 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 cct att atc aag tat att ctc att ggt gct ttg ggg ttg ctc gtg ata 528 Pro Ile Ile Lys Tyr Ile Leu Ile Gly Ala Leu Gly Leu Leu Val Ile 165 170 175 act tcg aaa gat taa 543 Thr Ser Lys Asp 180 <210> 526 <211> 180 <212> PRT <213> Oryza sativa Page 591 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 526 Met Gly Trp Ile Gly Glu Thr Val Asp Ser Ile Lys Ser Leu Gln Ile 1 5 10 15 Arg Gln Val Leu Thr Gln Ala Val Ser Leu Gly Met Ile Val Thr Ser 20 25 30 Ala Leu Ile Ile Trp Lys Ala Leu Met Cys Val Thr Gly Ser Glu Ser 35 40 45 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Ala Gly 65 70 75 80 Glu Ile Val Val Phe Asn Val Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 Arg Val Ile Lys Val His Glu Arg Glu Asp Thr Gly Glu Val Asp Val 100 105 110 Leu Thr Lys Gly Asp Asn Asn Tyr Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 His Gly Gln Leu Trp Leu Gln Arg His His Ile Met Gly Arg Ala Val 130 135 140 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 Pro Ile Ile Lys Tyr Ile Leu Ile Gly Ala Leu Gly Leu Leu Val Ile 165 170 175 Thr Ser Lys Asp 180 <210> 527 <211> 543 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(543) <400> 527 atg ggt tgg atc ggt gag act gtt gat tcc atc aaa tct ctt cag atc 48 Met Gly Trp Ile Gly Glu Thr Val Asp Ser Ile Lys Ser Leu Gln Ile 1 5 10 15 cgc cag gtc ctc acc cag gct gtg agc cta ggc atg att gtt acg tct 96 Arg Gln Val Leu Thr Gln Ala Val Ser Leu Gly Met Ile Val Thr Ser 20 25 30 gca ctg ata ata tgg aag gca ttg atg tgc gtt act ggc agt gaa tct 144 Ala Leu Ile Ile Trp Lys Ala Leu Met Cys Val Thr Gly Ser Glu Ser 35 40 45 ccc gtt gtt gtt gtt ctt tct gga agc atg gaa ccc gga ttc aag cgg 192 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 gga gac atc ttg ttc ttg cac atg agt aaa gat cct att cgg gca ggg 240 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Ala Gly 65 70 75 80 gag att gtt gtg ttt aat gtt gat gga cgt gag att cca att gtt cat 288 Glu Ile Val Val Phe Asn Val Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 cgt gta att aag gta cat gaa agg gaa gat act ggg gag gtt gat gtt 336 Arg Val Ile Lys Val His Glu Arg Glu Asp Thr Gly Glu Val Asp Val 100 105 110 ctc aca aaa gga gac aac aat tat ggg gat gac agg cta ctg tat gct 384 Leu Thr Lys Gly Asp Asn Asn Tyr Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 cat ggt caa ctt tgg ctg caa agg cac cac att atg ggt aga gcc gtc 432 His Gly Gln Leu Trp Leu Gln Arg His His Ile Met Gly Arg Ala Val 130 135 140 ggg ttc tta cca tac gta ggc tgg gtg acc atc att atg act gaa aag 480 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 cct att atc aag tat att ctc att ggt gct ttg ggg ttg ctc gtg ata 528 Pro Ile Ile Lys Tyr Ile Leu Ile Gly Ala Leu Gly Leu Leu Val Ile Page 592 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 165 170 175 act tcg aaa gat taa 543 Thr Ser Lys Asp 180 <210> 528 <211> 180 <212> PRT <213> Oryza sativa <400> 528 Met Gly Trp Ile Gly Glu Thr Val Asp Ser Ile Lys Ser Leu Gln Ile 1 5 10 15 Arg Gln Val Leu Thr Gln Ala Val Ser Leu Gly Met Ile Val Thr Ser 20 25 30 Ala Leu Ile Ile Trp Lys Ala Leu Met Cys Val Thr Gly Ser Glu Ser 35 40 45 Pro Val Val Val Val Leu Ser Gly Ser Met Glu Pro Gly Phe Lys Arg 50 55 60 Gly Asp Ile Leu Phe Leu His Met Ser Lys Asp Pro Ile Arg Ala Gly 65 70 75 80 Glu Ile Val Val Phe Asn Val Asp Gly Arg Glu Ile Pro Ile Val His 85 90 95 Arg Val Ile Lys Val His Glu Arg Glu Asp Thr Gly Glu Val Asp Val 100 105 110 Leu Thr Lys Gly Asp Asn Asn Tyr Gly Asp Asp Arg Leu Leu Tyr Ala 115 120 125 His Gly Gln Leu Trp Leu Gln Arg His His Ile Met Gly Arg Ala Val 130 135 140 Gly Phe Leu Pro Tyr Val Gly Trp Val Thr Ile Ile Met Thr Glu Lys 145 150 155 160 Pro Ile Ile Lys Tyr Ile Leu Ile Gly Ala Leu Gly Leu Leu Val Ile 165 170 175 Thr Ser Lys Asp 180 <210> 529 <211> 486 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(486) <400> 529 atg ata cat ttt gtg ctc ctc atc agc aga caa ggg aag gtg agg ctg 48 Met Ile His Phe Val Leu Leu Ile Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 acc aaa tgg tac aat cca tat cct cag aag gaa aga tcc aag gtt atc 96 Thr Lys Trp Tyr Asn Pro Tyr Pro Gln Lys Glu Arg Ser Lys Val Ile 20 25 30 aaa gaa gta agt acg ctc gtc ctg aca aga ggt cca aag atg tgc aat 144 Lys Glu Val Ser Thr Leu Val Leu Thr Arg Gly Pro Lys Met Cys Asn 35 40 45 ttt gtc gat tgg cac gga tac aga gtt gta tac aaa agg tat gca agc 192 Phe Val Asp Trp His Gly Tyr Arg Val Val Tyr Lys Arg Tyr Ala Ser 50 55 60 ctt tac ttc tgc atg tgc att gat gct gct gat aat gaa ctg gag act 240 Leu Tyr Phe Cys Met Cys Ile Asp Ala Ala Asp Asn Glu Leu Glu Thr 65 70 75 80 ctt caa atc atc cat cat ttt gtt gag ata ttg gac cga tat ttt ggc 288 Leu Gln Ile Ile His His Phe Val Glu Ile Leu Asp Arg Tyr Phe Gly 85 90 95 aat gtc tgc gag ctt gac ctg ata ttc aac ttc cac aag gca tac ttt 336 Asn Val Cys Glu Leu Asp Leu Ile Phe Asn Phe His Lys Ala Tyr Phe 100 105 110 ata ttg gat gag gtt ctg att gcc ggt gag ctt caa gaa tcg aac aag 384 Page 593 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ile Leu Asp Glu Val Leu Ile Ala Gly Glu Leu Gln Glu Ser Asn Lys 115 120 125 aaa gca gta cta cgc ctg atc act aca cag gac aac ttg gtg gaa gca 432 Lys Ala Val Leu Arg Leu Ile Thr Thr Gln Asp Asn Leu Val Glu Ala 130 135 140 gca aag gaa gag gca agc tca ttg agg aac ata att gca cag gcc acc 480 Ala Lys Glu Glu Ala Ser Ser Leu Arg Asn Ile Ile Ala Gln Ala Thr 145 150 155 160 aag tag 486 Lys <210> 530 <211> 161 <212> PRT <213> Oryza sativa <400> 530 Met Ile His Phe Val Leu Leu Ile Ser Arg Gln Gly Lys Val Arg Leu 1 5 10 15 Thr Lys Trp Tyr Asn Pro Tyr Pro Gln Lys Glu Arg Ser Lys Val Ile 20 25 30 Lys Glu Val Ser Thr Leu Val Leu Thr Arg Gly Pro Lys Met Cys Asn 35 40 45 Phe Val Asp Trp His Gly Tyr Arg Val Val Tyr Lys Arg Tyr Ala Ser 50 55 60 Leu Tyr Phe Cys Met Cys Ile Asp Ala Ala Asp Asn Glu Leu Glu Thr 65 70 75 80 Leu Gln Ile Ile His His Phe Val Glu Ile Leu Asp Arg Tyr Phe Gly 85 90 95 Asn Val Cys Glu Leu Asp Leu Ile Phe Asn Phe His Lys Ala Tyr Phe 100 105 110 Ile Leu Asp Glu Val Leu Ile Ala Gly Glu Leu Gln Glu Ser Asn Lys 115 120 125 Lys Ala Val Leu Arg Leu Ile Thr Thr Gln Asp Asn Leu Val Glu Ala 130 135 140 Ala Lys Glu Glu Ala Ser Ser Leu Arg Asn Ile Ile Ala Gln Ala Thr 145 150 155 160 Lys <210> 531 <211> 1083 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(1083) <400> 531 atg gag gtc acc ccc aac cac acg cag acc gtc tcc ggc tgg gcc gcc 48 Met Glu Val Thr Pro Asn His Thr Gln Thr Val Ser Gly Trp Ala Ala 1 5 10 15 atg gac gag tcc ggc aag atc gtg ccc ttc gtc ttc aag aga agg gag 96 Met Asp Glu Ser Gly Lys Ile Val Pro Phe Val Phe Lys Arg Arg Glu 20 25 30 aac ggg gtg gac gac gtg acg atc aag gtg aag tac tgc ggg atg tgc 144 Asn Gly Val Asp Asp Val Thr Ile Lys Val Lys Tyr Cys Gly Met Cys 35 40 45 cac acg gac ctg cac ttc atc cac aac gac tgg ggg atc acc atg tac 192 His Thr Asp Leu His Phe Ile His Asn Asp Trp Gly Ile Thr Met Tyr 50 55 60 ccg gtg gtg ccg ggg cac gag atc acc ggc gtg gtg acc aag gtg ggc 240 Pro Val Val Pro Gly His Glu Ile Thr Gly Val Val Thr Lys Val Gly 65 70 75 80 acc aac gtg gcc ggg ttc aag gtg ggc gac cgc gtg ggc gtg ggg tgc 288 Thr Asn Val Ala Gly Phe Lys Val Gly Asp Arg Val Gly Val Gly Cys Page 594 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 85 90 95 atc gcg gcg tcg tgc ctc gac tgc gag cac tgc cgg cgg tcg gag gag 336 Ile Ala Ala Ser Cys Leu Asp Cys Glu His Cys Arg Arg Ser Glu Glu 100 105 110 aac tac tgc gac aag gtg gcg ctc acc tac aac ggc atc ttc tgg gac 384 Asn Tyr Cys Asp Lys Val Ala Leu Thr Tyr Asn Gly Ile Phe Trp Asp 115 120 125 ggc agc atc acc tac ggc ggc tac tcc ggc atg ctg gtg gcg cac aag 432 Gly Ser Ile Thr Tyr Gly Gly Tyr Ser Gly Met Leu Val Ala His Lys 130 135 140 cgg ttc gtc gtg cgg atc ccg gac acc ctc ccg ctg gac gcc gcg gcg 480 Arg Phe Val Val Arg Ile Pro Asp Thr Leu Pro Leu Asp Ala Ala Ala 145 150 155 160 ccg ctg ctg tgc gcg ggc atc acg gtg tac agc ccc atg aag cag cac 528 Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Ser Pro Met Lys Gln His 165 170 175 ggc atg ctg cag gcc gac gcg gcc ggc cgg cgg ctc ggc gtg gtc ggc 576 Gly Met Leu Gln Ala Asp Ala Ala Gly Arg Arg Leu Gly Val Val Gly 180 185 190 ctc ggc ggc ctc ggc cac gtc gcc gtc aag ttc ggc aag gcg ttc ggc 624 Leu Gly Gly Leu Gly His Val Ala Val Lys Phe Gly Lys Ala Phe Gly 195 200 205 ctc cac gtc acc gtc atc agc acg tct ccg gcc aag gag cgc gag gcc 672 Leu His Val Thr Val Ile Ser Thr Ser Pro Ala Lys Glu Arg Glu Ala 210 215 220 agg gag aac ctc aag gcc gac aac ttc gtc gtc agc acc gac cag aag 720 Arg Glu Asn Leu Lys Ala Asp Asn Phe Val Val Ser Thr Asp Gln Lys 225 230 235 240 cag atg cag gct atg acg agg agc ctt gac tac atc att gac acg gtc 768 Gln Met Gln Ala Met Thr Arg Ser Leu Asp Tyr Ile Ile Asp Thr Val 245 250 255 gcg gcg acg cac tct ctg ggt ccg atc ctg gag ctg ctc aag gtc aac 816 Ala Ala Thr His Ser Leu Gly Pro Ile Leu Glu Leu Leu Lys Val Asn 260 265 270 ggc aag ctg gtg ctc gtg ggc gcg ccg gag aag ccc gtc gag ctc cct 864 Gly Lys Leu Val Leu Val Gly Ala Pro Glu Lys Pro Val Glu Leu Pro 275 280 285 tcc ttc cct ctc atc ttc ggt aag agg acg gtg agt ggg agc atg acg 912 Ser Phe Pro Leu Ile Phe Gly Lys Arg Thr Val Ser Gly Ser Met Thr 290 295 300 ggt ggg atg aag gag acg cag gag atg atg gac att tgc ggg gag cac 960 Gly Gly Met Lys Glu Thr Gln Glu Met Met Asp Ile Cys Gly Glu His 305 310 315 320 aac atc acc tgc gac atc gag atc gtg tcc acg gac agg atc aac gat 1008 Asn Ile Thr Cys Asp Ile Glu Ile Val Ser Thr Asp Arg Ile Asn Asp 325 330 335 gcg ctc gcc agg ttg gcg cgc aac gac gtc cgc tac cgc ttc gtc atc 1056 Ala Leu Ala Arg Leu Ala Arg Asn Asp Val Arg Tyr Arg Phe Val Ile 340 345 350 aac gtt ggg ggc gac tcc aag ctc tag 1083 Asn Val Gly Gly Asp Ser Lys Leu 355 360 <210> 532 <211> 360 <212> PRT <213> Oryza sativa <400> 532 Met Glu Val Thr Pro Asn His Thr Gln Thr Val Ser Gly Trp Ala Ala 1 5 10 15 Met Asp Glu Ser Gly Lys Ile Val Pro Phe Val Phe Lys Arg Arg Glu 20 25 30 Asn Gly Val Asp Asp Val Thr Ile Lys Val Lys Tyr Cys Gly Met Cys 35 40 45 His Thr Asp Leu His Phe Ile His Asn Asp Trp Gly Ile Thr Met Tyr 50 55 60 Pro Val Val Pro Gly His Glu Ile Thr Gly Val Val Thr Lys Val Gly Page 595 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 65 70 75 80 Thr Asn Val Ala Gly Phe Lys Val Gly Asp Arg Val Gly Val Gly Cys 85 90 95 Ile Ala Ala Ser Cys Leu Asp Cys Glu His Cys Arg Arg Ser Glu Glu 100 105 110 Asn Tyr Cys Asp Lys Val Ala Leu Thr Tyr Asn Gly Ile Phe Trp Asp 115 120 125 Gly Ser Ile Thr Tyr Gly Gly Tyr Ser Gly Met Leu Val Ala His Lys 130 135 140 Arg Phe Val Val Arg Ile Pro Asp Thr Leu Pro Leu Asp Ala Ala Ala 145 150 155 160 Pro Leu Leu Cys Ala Gly Ile Thr Val Tyr Ser Pro Met Lys Gln His 165 170 175 Gly Met Leu Gln Ala Asp Ala Ala Gly Arg Arg Leu Gly Val Val Gly 180 185 190 Leu Gly Gly Leu Gly His Val Ala Val Lys Phe Gly Lys Ala Phe Gly 195 200 205 Leu His Val Thr Val Ile Ser Thr Ser Pro Ala Lys Glu Arg Glu Ala 210 215 220 Arg Glu Asn Leu Lys Ala Asp Asn Phe Val Val Ser Thr Asp Gln Lys 225 230 235 240 Gln Met Gln Ala Met Thr Arg Ser Leu Asp Tyr Ile Ile Asp Thr Val 245 250 255 Ala Ala Thr His Ser Leu Gly Pro Ile Leu Glu Leu Leu Lys Val Asn 260 265 270 Gly Lys Leu Val Leu Val Gly Ala Pro Glu Lys Pro Val Glu Leu Pro 275 280 285 Ser Phe Pro Leu Ile Phe Gly Lys Arg Thr Val Ser Gly Ser Met Thr 290 295 300 Gly Gly Met Lys Glu Thr Gln Glu Met Met Asp Ile Cys Gly Glu His 305 310 315 320 Asn Ile Thr Cys Asp Ile Glu Ile Val Ser Thr Asp Arg Ile Asn Asp 325 330 335 Ala Leu Ala Arg Leu Ala Arg Asn Asp Val Arg Tyr Arg Phe Val Ile 340 345 350 Asn Val Gly Gly Asp Ser Lys Leu 355 360 <210> 533 <211> 639 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(639) <400> 533 atg ggc tcg aag ccg ccg ccg ccg ccg cag ccc agc gtc tcc ttc aag 48 Met Gly Ser Lys Pro Pro Pro Pro Pro Gln Pro Ser Val Ser Phe Lys 1 5 10 15 ctc gtc ctc ctc ggc gac ggg aga gta ggc aaa aca tct ctt gtg ctg 96 Leu Val Leu Leu Gly Asp Gly Arg Val Gly Lys Thr Ser Leu Val Leu 20 25 30 cgg tat gtg aat gat gtc ttc tca gac aaa cag gaa gca act gtt caa 144 Arg Tyr Val Asn Asp Val Phe Ser Asp Lys Gln Glu Ala Thr Val Gln 35 40 45 gct tca tat ttg aca aag cgc ctt gtt gtt gaa ggt gtg cct att acg 192 Ala Ser Tyr Leu Thr Lys Arg Leu Val Val Glu Gly Val Pro Ile Thr 50 55 60 ctc tct atc tgg gat aca gct gga caa gag aag ttc cat gca cta ggc 240 Leu Ser Ile Trp Asp Thr Ala Gly Gln Glu Lys Phe His Ala Leu Gly 65 70 75 80 cct ata tac tat cgt gat gca gac gct gct ctt tta gta tat gac atc 288 Pro Ile Tyr Tyr Arg Asp Ala Asp Ala Ala Leu Leu Val Tyr Asp Ile 85 90 95 aca gac aat gat act ttt ctt cgt gtc aca aag tgg gtg aaa gag ctt 336 Thr Asp Asn Asp Thr Phe Leu Arg Val Thr Lys Trp Val Lys Glu Leu Page 596 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 100 105 110 aag caa atg gca aat aaa gat att gtt atg gcc att gca gca aat aaa 384 Lys Gln Met Ala Asn Lys Asp Ile Val Met Ala Ile Ala Ala Asn Lys 115 120 125 agt gac ctg gtt aga tca aaa cac ata gac act aat gaa gca gca agc 432 Ser Asp Leu Val Arg Ser Lys His Ile Asp Thr Asn Glu Ala Ala Ser 130 135 140 tat gca gaa agt att ggg gca act ctc ttt gtt act tct gcc aaa gct 480 Tyr Ala Glu Ser Ile Gly Ala Thr Leu Phe Val Thr Ser Ala Lys Ala 145 150 155 160 ggt act ggg att gat gat atc ttc agt gac ata gcc aag aga tta tta 528 Gly Thr Gly Ile Asp Asp Ile Phe Ser Asp Ile Ala Lys Arg Leu Leu 165 170 175 gag aga aga aaa aac agc tcc gat ggc ttg tca ctg gct cat cca aag 576 Glu Arg Arg Lys Asn Ser Ser Asp Gly Leu Ser Leu Ala His Pro Lys 180 185 190 aaa ggc att tta atc gtc gac gat gaa cct gag aaa gaa cct cca cca 624 Lys Gly Ile Leu Ile Val Asp Asp Glu Pro Glu Lys Glu Pro Pro Pro 195 200 205 aag tgc tgc tca tag 639 Lys Cys Cys Ser 210 <210> 534 <211> 212 <212> PRT <213> Oryza sativa <400> 534 Met Gly Ser Lys Pro Pro Pro Pro Pro Gln Pro Ser Val Ser Phe Lys 1 5 10 15 Leu Val Leu Leu Gly Asp Gly Arg Val Gly Lys Thr Ser Leu Val Leu 20 25 30 Arg Tyr Val Asn Asp Val Phe Ser Asp Lys Gln Glu Ala Thr Val Gln 35 40 45 Ala Ser Tyr Leu Thr Lys Arg Leu Val Val Glu Gly Val Pro Ile Thr 50 55 60 Leu Ser Ile Trp Asp Thr Ala Gly Gln Glu Lys Phe His Ala Leu Gly 65 70 75 80 Pro Ile Tyr Tyr Arg Asp Ala Asp Ala Ala Leu Leu Val Tyr Asp Ile 85 90 95 Thr Asp Asn Asp Thr Phe Leu Arg Val Thr Lys Trp Val Lys Glu Leu 100 105 110 Lys Gln Met Ala Asn Lys Asp Ile Val Met Ala Ile Ala Ala Asn Lys 115 120 125 Ser Asp Leu Val Arg Ser Lys His Ile Asp Thr Asn Glu Ala Ala Ser 130 135 140 Tyr Ala Glu Ser Ile Gly Ala Thr Leu Phe Val Thr Ser Ala Lys Ala 145 150 155 160 Gly Thr Gly Ile Asp Asp Ile Phe Ser Asp Ile Ala Lys Arg Leu Leu 165 170 175 Glu Arg Arg Lys Asn Ser Ser Asp Gly Leu Ser Leu Ala His Pro Lys 180 185 190 Lys Gly Ile Leu Ile Val Asp Asp Glu Pro Glu Lys Glu Pro Pro Pro 195 200 205 Lys Cys Cys Ser 210 <210> 535 <211> 411 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(411) <400> 535 Page 597 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt atg gcc cgc acg aag cag acg gcg agg aag tcc acc ggc ggc aag gcg 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccg agg aag cag ctg gcg acg aag gcg gcg cgc aag tcg gcc ccg gcg 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 acc ggc ggc gtg aag aag ccc cac cgc ttc agg ccg gga acc gtc gcg 144 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 ctc cgg gag atc cgc aag tac cag aag agc acg gag ctg ctc atc cgc 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctg ccg ttc cag cgg ctg gtg cgg gag atc gcg cag gac ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acc gac ctc cgc ttc cag agc tcc gcc gtc gcc gcg ctg cag gag gcc 288 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 gcc gag gcc tac ctc gtc ggg ctc ttc gag gac acc aac ctc tgc gcc 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 atc cac gcc aag cgc gtc acc atc atg ccc aag gac atc cag ctc gcc 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 cgc cgc atc cgt ggc gag agg gcg tag 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 536 <211> 136 <212> PRT <213> Oryza sativa <400> 536 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Phe Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Ala Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 537 <211> 291 <212> DNA <213> Oryza sativa <400> 537 atgcctaagg ccgcaactgg aaagcgtggt gtcggcaaga tcgagaaggt caagcgcggt 60 aagaaggacc ccaacgctcc taagcgcggt ctctctgcct acatgttctt cgccaatgag 120 cagcgtgaga acgtccgtga tgagaacccc ggcatcagct tcggccaggt cggcaagctc 180 cttggccagc gctggaaggc actcgacgac aagcagcgtg ccccctacga ggccaaggct 240 gccgctgaca agaagcgcta cgaggacgag aaggccgcct acaactctta a 291 <210> 538 <211> 75 <212> PRT Page 598 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Oryza sativa <400> 538 Met Ser Ser Val Arg Thr Ser Val Met Arg Thr Pro Ala Ser Ala Ser 1 5 10 15 Ala Arg Ser Ala Ser Ser Leu Ala Ser Ala Gly Arg His Ser Thr Thr 20 25 30 Ser Ser Val Pro Pro Thr Arg Pro Arg Leu Pro Leu Thr Arg Ser Ala 35 40 45 Thr Arg Thr Arg Arg Pro Pro Thr Thr Leu Lys Trp Phe Pro Thr Thr 50 55 60 Val Met Ser Gln Phe Tyr Asp Asp Leu Pro Ile 65 70 75 <210> 539 <211> 318 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(318) <400> 539 atg gcg gag gaa gcc act cag ggg aag aag gag gag gag gaa ttc agt 48 Met Ala Glu Glu Ala Thr Gln Gly Lys Lys Glu Glu Glu Glu Phe Ser 1 5 10 15 acg ggg ccg ctg tcc gtg ctg atg atg agc gtg aag aac aac acc cag 96 Thr Gly Pro Leu Ser Val Leu Met Met Ser Val Lys Asn Asn Thr Gln 20 25 30 gtg ctt atc aat tgc cgg aac aac aag aag ttg ctt ggt cgt gtg agg 144 Val Leu Ile Asn Cys Arg Asn Asn Lys Lys Leu Leu Gly Arg Val Arg 35 40 45 gca ttt gat cgc cat tgc aac atg gtt ctt gag aat gtt agg gag atg 192 Ala Phe Asp Arg His Cys Asn Met Val Leu Glu Asn Val Arg Glu Met 50 55 60 tgg act gag gta cca aag act ggt aaa ggc aag aag aag gct ctt cca 240 Trp Thr Glu Val Pro Lys Thr Gly Lys Gly Lys Lys Lys Ala Leu Pro 65 70 75 80 gtg aac aag gac agg ttc att agc aag atg ttc cta cgt ggg gat tcg 288 Val Asn Lys Asp Arg Phe Ile Ser Lys Met Phe Leu Arg Gly Asp Ser 85 90 95 gtc atc att gtg ctc agg aac ccg aaa tga 318 Val Ile Ile Val Leu Arg Asn Pro Lys 100 105 <210> 540 <211> 105 <212> PRT <213> Oryza sativa <400> 540 Met Ala Glu Glu Ala Thr Gln Gly Lys Lys Glu Glu Glu Glu Phe Ser 1 5 10 15 Thr Gly Pro Leu Ser Val Leu Met Met Ser Val Lys Asn Asn Thr Gln 20 25 30 Val Leu Ile Asn Cys Arg Asn Asn Lys Lys Leu Leu Gly Arg Val Arg 35 40 45 Ala Phe Asp Arg His Cys Asn Met Val Leu Glu Asn Val Arg Glu Met 50 55 60 Trp Thr Glu Val Pro Lys Thr Gly Lys Gly Lys Lys Lys Ala Leu Pro 65 70 75 80 Val Asn Lys Asp Arg Phe Ile Ser Lys Met Phe Leu Arg Gly Asp Ser 85 90 95 Val Ile Ile Val Leu Arg Asn Pro Lys 100 105 <210> 541 Page 599 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 330 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(330) <400> 541 atg gcc acc ttc gag ctg tac cgg agg tcc acc atc ggt atg tgc ctc 48 Met Ala Thr Phe Glu Leu Tyr Arg Arg Ser Thr Ile Gly Met Cys Leu 1 5 10 15 acc gac acg ctg gac gac atg gtc tcc agt ggg gcg ctc agc ccc gag 96 Thr Asp Thr Leu Asp Asp Met Val Ser Ser Gly Ala Leu Ser Pro Glu 20 25 30 ctc gcc atc caa gtc ctc gtg cag ttt gac aag tcc atg act agc gct 144 Leu Ala Ile Gln Val Leu Val Gln Phe Asp Lys Ser Met Thr Ser Ala 35 40 45 ttg gag cat cag gtg aag agc aag gtt act gtc aag ggc cat ctg cac 192 Leu Glu His Gln Val Lys Ser Lys Val Thr Val Lys Gly His Leu His 50 55 60 acc tac agg ttc tgc gac aat gtg tgg act ttc atc cta aca gat gca 240 Thr Tyr Arg Phe Cys Asp Asn Val Trp Thr Phe Ile Leu Thr Asp Ala 65 70 75 80 att ttc aag aac gaa gag att aca gag aca ata aac aag gtg aag atc 288 Ile Phe Lys Asn Glu Glu Ile Thr Glu Thr Ile Asn Lys Val Lys Ile 85 90 95 gtg gcc tgc gat tcc aaa ttg ctg gag act aaa gaa gag taa 330 Val Ala Cys Asp Ser Lys Leu Leu Glu Thr Lys Glu Glu 100 105 <210> 542 <211> 109 <212> PRT <213> Oryza sativa <400> 542 Met Ala Thr Phe Glu Leu Tyr Arg Arg Ser Thr Ile Gly Met Cys Leu 1 5 10 15 Thr Asp Thr Leu Asp Asp Met Val Ser Ser Gly Ala Leu Ser Pro Glu 20 25 30 Leu Ala Ile Gln Val Leu Val Gln Phe Asp Lys Ser Met Thr Ser Ala 35 40 45 Leu Glu His Gln Val Lys Ser Lys Val Thr Val Lys Gly His Leu His 50 55 60 Thr Tyr Arg Phe Cys Asp Asn Val Trp Thr Phe Ile Leu Thr Asp Ala 65 70 75 80 Ile Phe Lys Asn Glu Glu Ile Thr Glu Thr Ile Asn Lys Val Lys Ile 85 90 95 Val Ala Cys Asp Ser Lys Leu Leu Glu Thr Lys Glu Glu 100 105 <210> 543 <211> 645 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(645) <400> 543 atg agc tcg gcg gcg gcg gcg acg agg ttc atc aag tgc gtc acc gtg 48 Met Ser Ser Ala Ala Ala Ala Thr Arg Phe Ile Lys Cys Val Thr Val 1 5 10 15 ggg gac ggc gcg gtg ggg aag acg tgc atg ctc atc tgc tac acc tgc 96 Gly Asp Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Cys 20 25 30 Page 600 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt aac aag ttc ccc acc gat tac atc ccc acc gtg ttc gac aac ttc agc 144 Asn Lys Phe Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser 35 40 45 gcc aat gtc tcc gtg gac ggg agc gtc gtc aac ctc ggc ctc tgg gac 192 Ala Asn Val Ser Val Asp Gly Ser Val Val Asn Leu Gly Leu Trp Asp 50 55 60 act gca ggt cag gag gat tac agc agg ttg agg cct ctg agc tac agg 240 Thr Ala Gly Gln Glu Asp Tyr Ser Arg Leu Arg Pro Leu Ser Tyr Arg 65 70 75 80 gga gcc gat gtg ttc atc ctg tcc ttc tcc ctg ata agc agg gcg agc 288 Gly Ala Asp Val Phe Ile Leu Ser Phe Ser Leu Ile Ser Arg Ala Ser 85 90 95 tat gag aat gtt cag aag aag tgg atg cca gag ctt cgc cgg ttt gcg 336 Tyr Glu Asn Val Gln Lys Lys Trp Met Pro Glu Leu Arg Arg Phe Ala 100 105 110 cct ggt gtt cct gta gtt ctt gtt gga acc aag ttg gat ctc cgt gaa 384 Pro Gly Val Pro Val Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu 115 120 125 gat agg gcc tat ctt gct gat cat cca gct tct tcc ata ata aca acg 432 Asp Arg Ala Tyr Leu Ala Asp His Pro Ala Ser Ser Ile Ile Thr Thr 130 135 140 gag cag gga gaa gaa ctg agg aag cta ata gga gcg gtc gcc tac atc 480 Glu Gln Gly Glu Glu Leu Arg Lys Leu Ile Gly Ala Val Ala Tyr Ile 145 150 155 160 gaa tgc agc tcc aag aca cag aga aac att aaa gct gtt ttc gac act 528 Glu Cys Ser Ser Lys Thr Gln Arg Asn Ile Lys Ala Val Phe Asp Thr 165 170 175 gcc atc aaa gtg gtg ctt caa cct cca aga cat aag gat gta acc aga 576 Ala Ile Lys Val Val Leu Gln Pro Pro Arg His Lys Asp Val Thr Arg 180 185 190 aag aaa ctc caa tca agc tcc aat cgg cca gta agg cgg tac ttt tgc 624 Lys Lys Leu Gln Ser Ser Ser Asn Arg Pro Val Arg Arg Tyr Phe Cys 195 200 205 gga agc gct tgt ttc gcg tag 645 Gly Ser Ala Cys Phe Ala 210 <210> 544 <211> 214 <212> PRT <213> Oryza sativa <400> 544 Met Ser Ser Ala Ala Ala Ala Thr Arg Phe Ile Lys Cys Val Thr Val 1 5 10 15 Gly Asp Gly Ala Val Gly Lys Thr Cys Met Leu Ile Cys Tyr Thr Cys 20 25 30 Asn Lys Phe Pro Thr Asp Tyr Ile Pro Thr Val Phe Asp Asn Phe Ser 35 40 45 Ala Asn Val Ser Val Asp Gly Ser Val Val Asn Leu Gly Leu Trp Asp 50 55 60 Thr Ala Gly Gln Glu Asp Tyr Ser Arg Leu Arg Pro Leu Ser Tyr Arg 65 70 75 80 Gly Ala Asp Val Phe Ile Leu Ser Phe Ser Leu Ile Ser Arg Ala Ser 85 90 95 Tyr Glu Asn Val Gln Lys Lys Trp Met Pro Glu Leu Arg Arg Phe Ala 100 105 110 Pro Gly Val Pro Val Val Leu Val Gly Thr Lys Leu Asp Leu Arg Glu 115 120 125 Asp Arg Ala Tyr Leu Ala Asp His Pro Ala Ser Ser Ile Ile Thr Thr 130 135 140 Glu Gln Gly Glu Glu Leu Arg Lys Leu Ile Gly Ala Val Ala Tyr Ile 145 150 155 160 Glu Cys Ser Ser Lys Thr Gln Arg Asn Ile Lys Ala Val Phe Asp Thr 165 170 175 Ala Ile Lys Val Val Leu Gln Pro Pro Arg His Lys Asp Val Thr Arg 180 185 190 Lys Lys Leu Gln Ser Ser Ser Asn Arg Pro Val Arg Arg Tyr Phe Cys Page 601 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 195 200 205 Gly Ser Ala Cys Phe Ala 210 <210> 545 <211> 321 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(321) <400> 545 atg gcc acc ttc gag ctc tac cgg agg tcc acc att ggc atg tgc ctc 48 Met Ala Thr Phe Glu Leu Tyr Arg Arg Ser Thr Ile Gly Met Cys Leu 1 5 10 15 act gag acg ctc gac gag atg gtc tcc agc ggc acc ctc agc ccg gag 96 Thr Glu Thr Leu Asp Glu Met Val Ser Ser Gly Thr Leu Ser Pro Glu 20 25 30 ctc gcc att caa gtt ctt gtc cag ttt gat aag tct atg acg gaa gcc 144 Leu Ala Ile Gln Val Leu Val Gln Phe Asp Lys Ser Met Thr Glu Ala 35 40 45 ttg gag aac caa gtc aag agc aag gtt tct atc aag ggc cac ctg cac 192 Leu Glu Asn Gln Val Lys Ser Lys Val Ser Ile Lys Gly His Leu His 50 55 60 act tac agg ttc tgt gac aat gta tgg aca ttc atc ttg act gaa gca 240 Thr Tyr Arg Phe Cys Asp Asn Val Trp Thr Phe Ile Leu Thr Glu Ala 65 70 75 80 tca ttc aag aac gag gag act aca gaa caa gtt ggc aag gtg aag att 288 Ser Phe Lys Asn Glu Glu Thr Thr Glu Gln Val Gly Lys Val Lys Ile 85 90 95 gtg gcc tgt gat tcc aaa cta ctc agc caa taa 321 Val Ala Cys Asp Ser Lys Leu Leu Ser Gln 100 105 <210> 546 <211> 106 <212> PRT <213> Oryza sativa <400> 546 Met Ala Thr Phe Glu Leu Tyr Arg Arg Ser Thr Ile Gly Met Cys Leu 1 5 10 15 Thr Glu Thr Leu Asp Glu Met Val Ser Ser Gly Thr Leu Ser Pro Glu 20 25 30 Leu Ala Ile Gln Val Leu Val Gln Phe Asp Lys Ser Met Thr Glu Ala 35 40 45 Leu Glu Asn Gln Val Lys Ser Lys Val Ser Ile Lys Gly His Leu His 50 55 60 Thr Tyr Arg Phe Cys Asp Asn Val Trp Thr Phe Ile Leu Thr Glu Ala 65 70 75 80 Ser Phe Lys Asn Glu Glu Thr Thr Glu Gln Val Gly Lys Val Lys Ile 85 90 95 Val Ala Cys Asp Ser Lys Leu Leu Ser Gln 100 105 <210> 547 <211> 411 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(411) <400> 547 atg gcc cgc aca aag cag acg gcg aag aag tcc acc gcc agc aat gtg 48 Page 602 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Met Ala Arg Thr Lys Gln Thr Ala Lys Lys Ser Thr Ala Ser Asn Val 1 5 10 15 ccg agg aag ctg ctg gtg atg aag gtg gca cgc aag tca gca ccg acg 96 Pro Arg Lys Leu Leu Val Met Lys Val Ala Arg Lys Ser Ala Pro Thr 20 25 30 atg gca ggg ctg aag aag cca cac cgc ttc aag cca ggg acc gtc gca 144 Met Ala Gly Leu Lys Lys Pro His Arg Phe Lys Pro Gly Thr Val Ala 35 40 45 ctc cga gag atc cgc aca tac cag aag agc aca gag ctg cta atc cgc 192 Leu Arg Glu Ile Arg Thr Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctc ccc ttc cag cgg ctg gtg cag gag atc gcg cag gac gtt agg 240 Lys Leu Pro Phe Gln Arg Leu Val Gln Glu Ile Ala Gln Asp Val Arg 65 70 75 80 tcc tat gtt cgc ttc cag agc tct gcc gtg gtt gcg ctg cag gag gct 288 Ser Tyr Val Arg Phe Gln Ser Ser Ala Val Val Ala Leu Gln Glu Ala 85 90 95 gcc gag acc tac ctt gtg ggg ctc ttc aag gac acc aac ctc tgt gtt 336 Ala Glu Thr Tyr Leu Val Gly Leu Phe Lys Asp Thr Asn Leu Cys Val 100 105 110 atc cat gcc aaa cgc gtc acc atc atg ccc aag gac atc cag ctc gcg 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 cgc cgc atc agg ggc gag aag gcc tag 411 Arg Arg Ile Arg Gly Glu Lys Ala 130 135 <210> 548 <211> 136 <212> PRT <213> Oryza sativa <400> 548 Met Ala Arg Thr Lys Gln Thr Ala Lys Lys Ser Thr Ala Ser Asn Val 1 5 10 15 Pro Arg Lys Leu Leu Val Met Lys Val Ala Arg Lys Ser Ala Pro Thr 20 25 30 Met Ala Gly Leu Lys Lys Pro His Arg Phe Lys Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Thr Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Gln Glu Ile Ala Gln Asp Val Arg 65 70 75 80 Ser Tyr Val Arg Phe Gln Ser Ser Ala Val Val Ala Leu Gln Glu Ala 85 90 95 Ala Glu Thr Tyr Leu Val Gly Leu Phe Lys Asp Thr Asn Leu Cys Val 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Lys Ala 130 135 <210> 549 <211> 348 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(348) <400> 549 atg tct gat ctc gac att cag atc cca act gcc ttc gat ccc ttt gct 48 Met Ser Asp Leu Asp Ile Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 gag gcc aat gct gga gac tct ggt gcg gct gca gga tca aag gac tac 96 Glu Ala Asn Ala Gly Asp Ser Gly Ala Ala Ala Gly Ser Lys Asp Tyr 20 25 30 Page 603 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gtt cat gta cgc atc cag cag cgt aat ggc cgt aag agc ctg acc act 144 Val His Val Arg Ile Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 gtc cag gga ttg aag aag gaa ttc agc tac aac aag atc ctc aaa gat 192 Val Gln Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp 50 55 60 ctc aag aaa gag ttt tgc tgc aat ggt act gtt gtc cag gac cca gag 240 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu 65 70 75 80 ctt ggc cag gtc att caa ctt cag ggt gat cag agg aaa aac gta tca 288 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser 85 90 95 aat ttt ctt gtt cag gcc ggc att gtg aag aag gaa cac atc aag att 336 Asn Phe Leu Val Gln Ala Gly Ile Val Lys Lys Glu His Ile Lys Ile 100 105 110 cat ggt ttc tga 348 His Gly Phe 115 <210> 550 <211> 115 <212> PRT <213> Oryza sativa <400> 550 Met Ser Asp Leu Asp Ile Gln Ile Pro Thr Ala Phe Asp Pro Phe Ala 1 5 10 15 Glu Ala Asn Ala Gly Asp Ser Gly Ala Ala Ala Gly Ser Lys Asp Tyr 20 25 30 Val His Val Arg Ile Gln Gln Arg Asn Gly Arg Lys Ser Leu Thr Thr 35 40 45 Val Gln Gly Leu Lys Lys Glu Phe Ser Tyr Asn Lys Ile Leu Lys Asp 50 55 60 Leu Lys Lys Glu Phe Cys Cys Asn Gly Thr Val Val Gln Asp Pro Glu 65 70 75 80 Leu Gly Gln Val Ile Gln Leu Gln Gly Asp Gln Arg Lys Asn Val Ser 85 90 95 Asn Phe Leu Val Gln Ala Gly Ile Val Lys Lys Glu His Ile Lys Ile 100 105 110 His Gly Phe 115 <210> 551 <211> 834 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(834) <400> 551 atg aag ctg gac gtc tcc gcc atg gag aac aac ttc gcc gcc cac gcc 48 Met Lys Leu Asp Val Ser Ala Met Glu Asn Asn Phe Ala Ala His Ala 1 5 10 15 gcc ggc ggc gag gac gac ggc ggc ctc ttc ggc gcc ggc gcc gac ctg 96 Ala Gly Gly Glu Asp Asp Gly Gly Leu Phe Gly Ala Gly Ala Asp Leu 20 25 30 ccc gcc atg gag ctc ccc acc tgc ccc gcc gac ttc gac ggg ttc cag 144 Pro Ala Met Glu Leu Pro Thr Cys Pro Ala Asp Phe Asp Gly Phe Gln 35 40 45 aag gag acc aag gag atg ctg aag cac aag aag gga acg acc acg ctc 192 Lys Glu Thr Lys Glu Met Leu Lys His Lys Lys Gly Thr Thr Thr Leu 50 55 60 gcg ttc atc ttc gac aag ggc gtc atc gtc gcc gcc gac tcc cgc gcc 240 Ala Phe Ile Phe Asp Lys Gly Val Ile Val Ala Ala Asp Ser Arg Ala 65 70 75 80 agc atg ggc gga tac ata tct tcg caa act gtg agg aaa att att gaa 288 Page 604 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Ser Met Gly Gly Tyr Ile Ser Ser Gln Thr Val Arg Lys Ile Ile Glu 85 90 95 ata aat ccg tac atg ctt gga aca atg gca gga ggt gct gct gat tgt 336 Ile Asn Pro Tyr Met Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys 100 105 110 caa ttt tgg cat agg aac ttg ggc atc aag tgc cga ctc cat gag ctc 384 Gln Phe Trp His Arg Asn Leu Gly Ile Lys Cys Arg Leu His Glu Leu 115 120 125 gcg aac aag cgg agg atc tct att gct ggt gct tca aag ctt ttg gcc 432 Ala Asn Lys Arg Arg Ile Ser Ile Ala Gly Ala Ser Lys Leu Leu Ala 130 135 140 aac atc ctg tac tcc tac cgt ggg atg gga ctg tca att ggt aca atg 480 Asn Ile Leu Tyr Ser Tyr Arg Gly Met Gly Leu Ser Ile Gly Thr Met 145 150 155 160 att gct gga tgg gat gag aag ggt cct ggc ttg tac tat gtt gat agt 528 Ile Ala Gly Trp Asp Glu Lys Gly Pro Gly Leu Tyr Tyr Val Asp Ser 165 170 175 gag ggc gca agg ctc atg gga agc cga ttc tct gtt gga tca ggt tct 576 Glu Gly Ala Arg Leu Met Gly Ser Arg Phe Ser Val Gly Ser Gly Ser 180 185 190 ctg tat gcc tat ggt atc ttg gac gag ggt tac cgc tat gtg atg cca 624 Leu Tyr Ala Tyr Gly Ile Leu Asp Glu Gly Tyr Arg Tyr Val Met Pro 195 200 205 gtt gag gaa gct gct gag tta gca agg cgg gct att tac caa gct aca 672 Val Glu Glu Ala Ala Glu Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr 210 215 220 ttc cgt gat ggg gca agt ggt ggt tgt gtt agc gtt tac cat gtt ggc 720 Phe Arg Asp Gly Ala Ser Gly Gly Cys Val Ser Val Tyr His Val Gly 225 230 235 240 ccg aac ggc tgg acg aag ctt tct gga gat gat gtt ggg gag ctg cac 768 Pro Asn Gly Trp Thr Lys Leu Ser Gly Asp Asp Val Gly Glu Leu His 245 250 255 tac aag tac tac ccg gtt gag gcc act cct gtc gag cag gaa atg gcc 816 Tyr Lys Tyr Tyr Pro Val Glu Ala Thr Pro Val Glu Gln Glu Met Ala 260 265 270 gat gcc cca gct gct taa 834 Asp Ala Pro Ala Ala 275 <210> 552 <211> 277 <212> PRT <213> Oryza sativa <400> 552 Met Lys Leu Asp Val Ser Ala Met Glu Asn Asn Phe Ala Ala His Ala 1 5 10 15 Ala Gly Gly Glu Asp Asp Gly Gly Leu Phe Gly Ala Gly Ala Asp Leu 20 25 30 Pro Ala Met Glu Leu Pro Thr Cys Pro Ala Asp Phe Asp Gly Phe Gln 35 40 45 Lys Glu Thr Lys Glu Met Leu Lys His Lys Lys Gly Thr Thr Thr Leu 50 55 60 Ala Phe Ile Phe Asp Lys Gly Val Ile Val Ala Ala Asp Ser Arg Ala 65 70 75 80 Ser Met Gly Gly Tyr Ile Ser Ser Gln Thr Val Arg Lys Ile Ile Glu 85 90 95 Ile Asn Pro Tyr Met Leu Gly Thr Met Ala Gly Gly Ala Ala Asp Cys 100 105 110 Gln Phe Trp His Arg Asn Leu Gly Ile Lys Cys Arg Leu His Glu Leu 115 120 125 Ala Asn Lys Arg Arg Ile Ser Ile Ala Gly Ala Ser Lys Leu Leu Ala 130 135 140 Asn Ile Leu Tyr Ser Tyr Arg Gly Met Gly Leu Ser Ile Gly Thr Met 145 150 155 160 Ile Ala Gly Trp Asp Glu Lys Gly Pro Gly Leu Tyr Tyr Val Asp Ser 165 170 175 Glu Gly Ala Arg Leu Met Gly Ser Arg Phe Ser Val Gly Ser Gly Ser Page 605 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt 180 185 190 Leu Tyr Ala Tyr Gly Ile Leu Asp Glu Gly Tyr Arg Tyr Val Met Pro 195 200 205 Val Glu Glu Ala Ala Glu Leu Ala Arg Arg Ala Ile Tyr Gln Ala Thr 210 215 220 Phe Arg Asp Gly Ala Ser Gly Gly Cys Val Ser Val Tyr His Val Gly 225 230 235 240 Pro Asn Gly Trp Thr Lys Leu Ser Gly Asp Asp Val Gly Glu Leu His 245 250 255 Tyr Lys Tyr Tyr Pro Val Glu Ala Thr Pro Val Glu Gln Glu Met Ala 260 265 270 Asp Ala Pro Ala Ala 275 <210> 553 <211> 411 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(411) <400> 553 atg gcc cgt acc aag cag acc gct cgt aag tcc aca gga gga aag gct 48 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 ccc agg aag cag ctt gca acc aag gct gct cgt aag tct gct ccc acc 96 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 act gga gga gtt aag aag ccc cac cgt tac cgc cct gga act gtt gcc 144 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 ctc cgt gag att cgc aag tac cag aag agt act gag ctt ttg atc agg 192 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 aag ctg ccc ttc cag agg ctt gtt agg gaa att gca cag gac ttc aag 240 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 acc gat ctg cgt ttc cag agc cat gct gtc ctt gcc ctc cag gag gct 288 Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 gcg gag gca tac ctt gtt ggt ctc ttc gag gac acc aac ctg tgc gct 336 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 att cat gcc aag cgt gtg acc atc atg cct aag gac att cag ctg gct 384 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 agg agg att cgt ggt gag agg gct taa 411 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 554 <211> 136 <212> PRT <213> Oryza sativa <400> 554 Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 1 5 10 15 Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Thr 20 25 30 Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 35 40 45 Leu Arg Glu Ile Arg Lys Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 50 55 60 Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 65 70 75 80 Page 606 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Thr Asp Leu Arg Phe Gln Ser His Ala Val Leu Ala Leu Gln Glu Ala 85 90 95 Ala Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 100 105 110 Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 115 120 125 Arg Arg Ile Arg Gly Glu Arg Ala 130 135 <210> 555 <211> 450 <212> DNA <213> Oryza sativa <220> <221> CDS <222> (1)..(450) <400> 555 atg gca gat cag ctc acc gac gac cag atc gcc gag ttc aag gag gcc 48 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Ala Glu Phe Lys Glu Ala 1 5 10 15 ttc agc ctc ttc gac aag gac ggc gat ggt tgc atc aca acc aag gag 96 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 ttg gga act gtc atg cgt tca cta ggg cag aac cca acg gaa gct gag 144 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 ctc cag gac atg atc aac gag gtt gat gct gat ggc aat gga acc att 192 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 gat ttt cct gag ttt ctc aat ctg atg gct cgc aag atg aag gac act 240 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 gat tca gag gaa gaa ctc aag gag gcc ttc cgg gtg ttt gac aag gac 288 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 caa aat ggc ttc atc tcc gct gct gag ctc cgc cat gtg atg aca aat 336 Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 ctt ggc gag aag cta act gac gag gag gtg gat gag atg atc cgt gag 384 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 gct gat gtt gat ggt gat ggt cag ata aac tat gag gag ttt gtg aag 432 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 gtc atg atg gcc aag tga 450 Val Met Met Ala Lys 145 <210> 556 <211> 149 <212> PRT <213> Oryza sativa <400> 556 Met Ala Asp Gln Leu Thr Asp Asp Gln Ile Ala Glu Phe Lys Glu Ala 1 5 10 15 Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Cys Ile Thr Thr Lys Glu 20 25 30 Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 35 40 45 Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 50 55 60 Asp Phe Pro Glu Phe Leu Asn Leu Met Ala Arg Lys Met Lys Asp Thr 65 70 75 80 Asp Ser Glu Glu Glu Leu Lys Glu Ala Phe Arg Val Phe Asp Lys Asp 85 90 95 Page 607 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt Gln Asn Gly Phe Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 100 105 110 Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 115 120 125 Ala Asp Val Asp Gly Asp Gly Gln Ile Asn Tyr Glu Glu Phe Val Lys 130 135 140 Val Met Met Ala Lys 145 <210> 557 <211> 13 <212> PRT <213> Saccharomyces cerevisiae <220> <221> misc_feature <222> (2)..(2) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (4)..(5) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (8)..(10) <223> Xaa can be any naturally occurring amino acid <400> 557 Lys Xaa Val Xaa Xaa Gly Asp Xaa Xaa Xaa Gly Lys Thr 1 5 10 <210> 558 <211> 9 <212> PRT <213> Saccharomyces cerevisiae <220> <221> misc_feature <222> (2)..(4) <223> Xaa can be any naturally occurring amino acid <220> <221> misc_feature <222> (6)..(7) <223> Xaa can be any naturally occurring amino acid <400> 558 Phe Xaa Xaa Xaa Tyr Xaa Xaa Thr Val 1 5 <210> 559 <211> 7 <212> PRT <213> Saccharomyces cerevisiae <400> 559 Trp Asp Thr Ala Gly Gln Glu 1 5 Page 608 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 560 <211> 7 <212> PRT <213> Saccharomyces cerevisiae <220> <221> misc_feature <222> (5)..(5) <223> Xaa can be any naturally occurring amino acid <400> 560 Val Gly Thr Lys Xaa Asp Leu 1 5 <210> 561 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 561 ggaattccag ctgaccacca tggatggagc caaatttgaa aatac 45 <210> 562 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 562 ggaattccag ctgaccacca tgagcgaaat aaataatgaa aatctag 47 <210> 563 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 563 ggaattccag ctgaccacca tgcagtttcc attcgcttgt ctc 43 <210> 564 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 564 ggaattccag ctgaccacca tgaaattttt gaagaacaaa gcacc 45 <210> 565 <211> 43 <212> DNA <213> Artificial Sequence <220> Page 609 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <223> primer forward <400> 565 ggaattccag ctgaccacca tgtgcgccag tttaaacgag gta 43 <210> 566 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 566 ggaattccag ctgaccacca tggtcgtaat taacggggtc aaat 44 <210> 567 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 567 ggaattccag ctgaccacca tgttgcagct aaggtttatg cct 43 <210> 568 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 568 ggaattccag ctgaccacca tgaagctccc acagaccatg ct 42 <210> 569 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 569 ggaattccag ctgaccacca tggctctagc tatctcccac ga 42 <210> 570 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 570 ggaattccag ctgaccacca tggttttttc ttatgagcac tatatg 46 <210> 571 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 571 Page 610 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggaattccag ctgaccacca tgcgatatac tgcaactttt cgg 43 <210> 572 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 572 ggaattccag ctgaccacca tgcaattctc taccgtcgct tct 43 <210> 573 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 573 ggaattccag ctgaccacca tgaatagcga gtacgattac ctgt 44 <210> 574 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 574 ggaattccag ctgaccacca tggcccgcaa tagacaagcg t 41 <210> 575 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 575 ggaattccag ctgaccacca tgtcggatgt agataactgg gaa 43 <210> 576 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 576 ggaattccag ctgaccacca tgcctccaaa gaagcaagtc gaa 43 <210> 5777 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 577 ggaattccag ctgaccacca tgactgtggt tgaaataaaa agcc 44 Page 611 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 578 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 578 ggaattccag ctgaccacca tgcacattct tttcttgttt attttc 46 <210> 579 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 579 ggaattccag ctgaccacca tgtctacctt ttctgcttct gatt 44 <210> 580 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 580 ggaattccag ctgaccacca tgaaaggttc aaaatcgcac cttg 44 <210> 581 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 581 ggaattccag ctgaccacca tgccgaagaa tagtcaccac cat 43 <210> 582 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 582 ggaattccag ctgaccacca tgtcccaacg atcttcacaa cac 43 <210> 583 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 583 ggaattccag ctgaccacca tggccgatga ggaacgttta aag 43 <210> 584 Page 612 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 584 ggaattccag ctgaccacca tgatcgcttt gaagcccaat gct 43 <210> 585 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 585 ggaattccag ctgaccacca tgaaggattt aaaattatcg aatttca 47 <210> 586 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 586 ggaattccag ctgaccacca tggagaccaa tttttccttc gact 44 <210> 587 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 587 ggaattccag ctgaccacca tgaaatgtca cgcgaaacgg ac 42 <210> 588 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 588 ggaattccag ctgaccacca tgaaaactga tagattactg attaac 46 <210> 589 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 589 ggaattccag ctgaccacca tgacaaaaag tgatttatta tttgataa 48 <210> 590 <211> 44 <212> DNA Page 613 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Artificial Sequence <220> <223> primer forward <400> 590 ggaattccag ctgaccacca tgaaaggctc acccatttct caat 44 <210> 591 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 591 ggaattccag ctgaccacca tggcgtataa tcaagaagat agtaa 45 <210> 592 <211> 50 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 592 ggaattccag ctgaccacca tgaccttttt acaatttatc aataataata 50 <210> 593 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 593 ggaattccag ctgaccacca tgagtctctc gcaggtgtca c 41 <210> 594 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 594 ggaattccag ctgaccacca tggatccaag tttagtttta gagc 44 <210> 595 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 595 ggaattccag ctgaccacca tggagagtcg aactacaggg c 41 <210> 596 <211> 43 <212> DNA <213> Artificial Sequence Page 614 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <223> primer forward <400> 596 ggaattccag ctgaccacca tgtgcatttt aatggccaca agg 43 <210> 597 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 597 ggaattccag ctgaccacca tgtacatggc cagatgtggc c 41 <210> 598 <211> 40 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 598 ggaattccag ctgaccacca tgcagacaat gggcggggag 40 <210> 599 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 599 ggaattccag ctgaccacca tgattcaatt taaaagtcca ggtaac 46 <210> 600 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 600 ggaattccag ctgaccacca tgtcatctga caactctaaa caag 44 <210> 601 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 601 ggaattccag ctgaccacca tgtcgacagc acagaaagct aag 43 <210> 602 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward Page 615 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 602 ggaattccag ctgaccacca tgaacaaaga attggcttct aagtt 45 <210> 603 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 603 ggaattccag ctgaccacca tggaaactga agtacctgca cca 43 <210> 604 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 604 ggaattccag ctgaccacca tggatgatat aagcggaagg caaa 44 <210> 605 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 605 ggaattccag ctgaccacca tgcctgtccc atctgttact gt 42 <210> 606 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 606 ggaattccag ctgaccacca tgtacattcc taaacatttt gagtc 45 <210> 607 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 607 ggaattccag ctgaccacca tggcagtacc cgggtattac ga 42 <210> 608 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer forward Page 616 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 608 ggaattccag ctgaccacca tgactaaaag tatatatatt atcatcg 47 <210> 609 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 609 ggaattccag ctgaccacca tgttcttaag aagcgttaac cgtg 44 <210> 610 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 610 ggaattccag ctgaccacca tgactcgtcc cccattggtt c 41 <210> 611 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 611 ggaattccag ctgaccacca tgaatctaag atttgaattg cagaaa 46 <210> 612 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 612 ggaattccag ctgaccacca tggccaagag gaaatatggc ag 42 <210> 613 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 613 ggaattccag ctgaccacca tgatcgcctt accagtagag aag 43 <210> 614 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 614 ggaattccag ctgaccacca tgttcaggat acaactgaga acta 44 Page 617 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 615 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 615 ggaattccag ctgaccacca tggatgataa gaaaacatgg agtac 45 <210> 616 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 616 ggaattccag ctgaccacca tgaatcttaa actttctgct attgaa 46 <210> 617 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 617 ggaattccag ctgaccacca tgattcatgc agttctaata tgtatg 46 <210> 618 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 618 ggaattccag ctgaccacca tggaagcaca taaccaattt ttgaa 45 <210> 619 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 619 ggaattccag ctgaccacca tgtcacagat agcacaagaa atga 44 <210> 620 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 620 ggaattccag ctgaccacca tgaatggaat tcaagtggac atca 44 Page 618 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 621 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 621 ggaattccag ctgaccacca tgtgcagtag gatactcttg tcc 43 <210> 622 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 622 ggaattccag ctgaccacca tgccgcattt agccgccgaa g 41 <210> 623 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 623 ggaattccag ctgaccacca tgttaaaagt tcctttgagt gatgt 45 <210> 624 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 624 ggaattccag ctgaccacca tggacagaga ccatattaat gacc 44 <210> 625 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 625 ggaattccag ctgaccacca tggctgtcgg aaagaataag aga 43 <210> 626 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 626 ggaattccag ctgaccacca tgtatctcag tgcccagctt atg 43 <210> 627 <211> 44 Page 619 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 627 ggaattccag ctgaccacca tgggtggaga aattattact ttgc 44 <210> 628 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 628 ggaattccag ctgaccacca tgggtgccta caaatatttg gaag 44 <210> 629 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 629 ggaattccag ctgaccacca tgttgaacgt gctattgaga agga 44 <210> 630 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 630 ggaattccag ctgaccacca tgtctaaagg gagggtcaat cag 43 <210> 631 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 631 ggaattccag ctgaccacca tgtcatcaag aataattgtc ggca 44 <210> 632 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 632 ggaattccag ctgaccacca tgtcctcaca agaatataca acttt 45 <210> 633 <211> 44 <212> DNA <213> Artificial Sequence Page 620 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <223> primer forward <400> 633 ggaattccag ctgaccacca tgtcgcacca aaaccagctt att 43 <210> 634 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 634 ggaattccag ctgaccacca tgggtaagaa aaacactaaa ggtg 44 <210> 635 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 635 ggaattccag ctgaccacca tgataaaagt cgatacttcc gatg 44 <210> 636 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 636 ggaattccag ctgaccacca tgactgtttc tacttccaag acc 43 <210> 637 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 637 ggaattccag ctgaccacca tgagttccct attaatatca tacga 45 <210> 638 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 638 ggaattccag ctgaccacca tgagagactc taatcatcga tcat 44 <210> 639 <211> 45 <212> DNA <213> Artificial Sequence <220> Page 621 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <223> primer forward <400> 639 ggaattccag ctgaccacca tgcgtctaaa agaattgtta cctaa 45 <210> 640 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 640 ggaattccag ctgaccacca tgtcttatcc tgagaaattt gaagg 45 <210> 641 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 641 ggaattccag ctgaccacca tgcgttcttc ggtatatagt gaga 44 <210> 642 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 642 ggaattccag ctgaccacca tgtcgcggga ggcatttgat gt 42 <210> 643 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 643 ggaattccag ctgaccacca tggagagtat atttggtggg tttg 44 <210> 644 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 644 ggaattccag ctgaccacca tgtcaacgca ctcaaacgac tac 43 <210> 645 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 645 Page 622 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ggaattccag ctgaccacca tgttgctaat aagaaggacg ataaa 45 <210> 646 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 646 ggaattccag ctgaccacca tgcttttaca aggaatgcgt ttatc 45 <210> 647 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 647 ggaattccag ctgaccacca tgtccattga gaatctgaaa tcatt 45 <210> 648 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 648 ggaattccag ctgaccacca tgaccgtcgt tatcggagtc tt 42 <210> 649 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 649 ggaattccag ctgaccacca tgaagatttt aacccaagac gaaat 45 <210> 650 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 650 ggaattccag ctgaccacca tgtcgcatac tttaaaatcg aaaac 45 <210> 651 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 651 ggaattccag ctgaccacca tgtcttttag aaagaaaaaa ctcaaac 47 Page 623 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 652 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 652 ggaattccag ctgaccacca tgagctctga cgaagaagat ttca 44 <210> 653 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 653 ggaattccag ctgaccacca tgtccaccct tttgaagtct gct 43 <210> 654 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 654 ggaattccag ctgaccacca tggcaagtaa ccagcacata gga 43 <210> 655 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 655 ggaattccag ctgaccacca tgataaaaaa ctatttggga cgaag 45 <210> 656 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 656 ggaattccag ctgaccacca tgatatcacc atcaaaaaag agaac 45 <210> 657 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 657 ggaattccag ctgaccacca tgatgcccta caacacccct c 41 <210> 658 Page 624 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 658 ggaattccag ctgaccacca tgaaactggc gcaagacatg aat 43 <210> 659 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 659 ggaattccag ctgaccacca tggaggtaac ttcaatgttt ctca 44 <210> 660 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 660 ggaattccag ctgaccacca tgactacaaa taatgacttc tattttg 47 <210> 61 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 661 ggaattccag ctgaccacca tgtctggtta tttttcaggg ttttc 45 <210> 662 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 373 ggaattccag ctgaccacca tggctgaaat gaagaattcg acag 44 <210> 663 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 663 ggaattccag ctgaccacca tgcgcgtttt tactttgatt gcga 44 <210> 664 Page 625 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 664 ggaattccag ctgaccacca tgggtaaatc gtatgtccat ataac 45 <210> 665 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 665 ggaattccag ctgaccacca tgtcaattca ggcttttgtc ttttg 45 <210> 666 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 666 ggaattccag ctgaccacca tgtccaccct ttttctgatt ggaa 44 <210> 667 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 667 ggaattccag ctgaccacca tggcaggtca ttcacacagg tc 42 <210> 668 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 668 ggaattccag ctgaccacca tggtagtaca aaatagccca gttt 44 <210> 669 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 669 ggaattccag ctgaccacca tgaaagaaag caaaaaaatg gctaaa 46 <210> 670 <211> 42 <212> DNA Page 626 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <213> Artificial Sequence <220> <223> primer forward <400> 670 ggaattccag ctgaccacca tgaaagcaac cattcaaaga gtaac 45 <210> 671 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 671 ggaattccag ctgaccacca tggtcacccc aagagaacct aa 42 <210> 672 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 672 ggaattccag ctgaccacca tgaatcagag cgatagcagc ttg 43 <210> 673 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 673 ggaattccag ctgaccacca tgtcgtatgt ttgatcttaa ccatt 45 <210> 674 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 674 ggaattccag ctgaccacca tgaatgattg gcatgagttc aatg 44 <210> 675 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 675 ggaattccag ctgaccacca tggatagagg caggtggtgt tt 42 <210> 676 <211> 43 <212> DNA <213> Artificial Sequence Page 627 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <223> primer forward <400> 676 ggaattccag ctgaccacca tgaaacagat agtcaaaaga agcc 44 <210> 677 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 677 ggaattccag ctgaccacca tgggcacact gtttcgaaga aat 43 <210> 678 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 678 ggaattccag ctgaccacca tggaacagaa caggttcaag aaag 44 <210> 679 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 679 ggaattccag ctgaccacca tgtcatctca gtttttcctg aaaac 45 <210> 680 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 680 ggaattccag ctgaccacca tgtcagccac cagagccaat aaa 43 <210> 681 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 681 ggaattccag ctgaccacca tgtattcaat tgttaaagag attattg 47 <210> 682 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward Page 628 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 682 ggaattccag ctgaccacca tgaaggcgtc gcacatttgc tc 42 <210> 683 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 683 ggaattccag ctgaccacca tggatatggt atcaccagtc ttga 44 <210> 684 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 684 ttgctcttcc atgaaacatc tgcatcgatt ctttag 36 <210> 685 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 685 ttgctcttcc atgagtgcgt taaataagaa aag 33 <210> 686 <211> 35 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 686 ttgctcttcc atggaaacga ctcaaaccag cac 33 <210> 687 <211> 34 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 687 ttgctcttcc atgtttcatt gtcctttatg ccagc 35 <210> 688 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 688 ttgctcttcc atggcaatta acaatacagg ctcg 34 Page 629 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 689 <211> 34 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 689 ttgctcttcc atgagtactt cagatagcat tgtatc 36 <210> 690 <211> 37 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 690 ttgctcttcc atgaacatgt tttttaggct tacc 34 <210> 691 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 691 ttgctcttcc atgttcatgg caacttatat gactttt 37 <210> 692 <211> 35 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 692 ttgctcttcc atgatcagga gtcacaccat ga 32 <210> 693 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 693 ttgctcttcc atgatggcta acagaatgat tctga 35 <210> 694 <211> 35 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 694 ttgctcttcc atgaattatc gctatcgcgc ca 32 Page 630 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 695 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 695 ttgctcttcc atggatcgta ttgttagttc ttcac 35 <210> 696 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 696 ggaattccag ctgaccacca tgtccaacaa gctgttcagg tta 43 <210> 697 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 697 ggaattccag ctgaccacca tggtagcaac aataatgcag acga 44 <210> 698 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 698 ggaattccag ctgaccacca tgaatccggg cggtgaacaa ac 42 <210> 699 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 699 ggaattccag ctgaccacca tggacaaaat cagagaaaag ctaag 45 <210> 700 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 700 ggaattccag ctgaccacca tggcaggtat caagttgacg cat 43 <210> 701 <211> 45 Page 631 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 701 ggaattccag ctgaccacca tgtgtgaatc atcaaataag actga 45 <210> 702 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 702 ggaattccag ctgaccacca tggaggaaca acgtgaaata ctg 43 <210> 703 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 703 ggaattccag ctgaccacca tgtctgaaaa ggccgttaga agg 43 <210> 704 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 704 ggaattccag ctgaccacca tgatcgctac ctccagagcc g 41 <210> 705 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer forward <400> 705 ggaattccag ctgaccacca tggcctcctc aagtagcacg c 41 <210> 706 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 706 gatccccggg aattgccatg ttacacatca ttgcaagctg attgt 45 <210> 707 <211> 46 <212> DNA <213> Artificial Sequence Page 632 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <223> primer reverse <400> 707 gatccccggg aattgccatg ttatagagaa ggagacattg aaacat 46 <210> 708 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 708 gatccccggg aattgccatg tcaaacttcg ttccaaccca ggg 43 <210> 709 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 709 gatccccggg aattgccatg tcaattgcag ggattatgga ataaaa 46 <210> 710 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 710 gatccccggg aattgccatg ttagaactga acagaaccca tggc 44 <210> 711 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 711 gatccccggg aattgccatg ttattgtgaa tgtgagttat gcgaag 46 <210> 712 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 712 gatccccggg aattgccatg ttactttgat cccttcgatt ctgca 45 <210> 713 <211> 42 <212> DNA <213> Artificial Sequence <220> Page 633 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <223> primer reverse <400> 713 gatccccggg aattgccatg tcatgatgat gccggaccct tc 42 <210> 714 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 714 gatccccggg aattgccatg ctacattttc atggtttctt caactc 46 <210> 715 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 715 gatccccggg aattgccatg tcatccaata aagctaacac ttgttc 46 <210> 716 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 716 gatccccggg aattgccatg ctatggttcg ctattcaata ttagaa 46 <210> 717 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 717 gatccccggg aattgccatg ttacaacaat aaagcggcag cacc 44 <210> 718 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 718 gatccccggg aattgccatg tcaacagcag cccccaccgg t 41 <210> 719 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 719 Page 634 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gatccccggg aattgccatg ttaaggaagc gcatctacat cttct 45 <210> 720 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 720 gatccccggg aattgccatg tcaaccatac ctttgatcca actg 44 <210> 721 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 721 gatccccggg aattgccatg tcaattctta ccagcaccag ctct 44 <210> 722 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 722 gatccccggg aattgccatg ttactgtaga gcatgttgga aatatt 46 <210> 723 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 723 gatccccggg aattgccatg ttatatatgg catgtcttcg catgt 45 <210> 724 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 724 gatccccggg aattgccatg tcagaccctt ttgccaagtt tgtaa 45 <210> 725 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 725 gatccccggg aattgccatg ttactcacca ttaaaacatc tttccc 46 Page 635 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 726 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 726 gatccccggg aattgccatg ttagttgcta ttatcaaaat aaaaagac 48 <210> 727 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 727 gatccccggg aattgccatg tcaaaaaaaa aaaggaaaaa gagaaaag 48 <210> 728 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 728 gatccccggg aattgccatg tcacattttt ctaaattcac ttagcac 47 <210> 479 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 729 gatccccggg aattgccatg ttagtatgta ggcttagtaa cccaa 45 <210> 730 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 730 gatccccggg aattgccatg tcaaccctca aaatttgctt tatcg 45 <210> 731 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 731 gatccccggg aattgccatg ctattgaaat accggcttca atattt 46 <210> 732 Page 636 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 732 gatccccggg aattgccatg ctaggaaagg aggtggttac gaa 43 <210> 733 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 733 gatccccggg aattgccatg ttagattgca aaatgagcct gacga 45 <210> 734 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 734 gatccccggg aattgccatg ttaccaagcg gaccatgacc cg 42 <210> 735 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 735 gatccccggg aattgccatg ttatccacgc tccttataac atgaa 45 <210> 736 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 736 gatccccggg aattgccatg ttacgtactt ccatttgctt cctct 45 <210> 737 <211> 50 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 737 gatccccggg aattgccatg tcagttcatc aaaattgaaa tttctaacca 50 <210> 738 <211> 45 Page 637 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 738 gatccccggg aattgccatg tcagttggga attaggataa tatcc 45 <210> 739 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 739 gatccccggg aattgccatg tcagttacgt tttcttttca gtttgt 46 <210> 740 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 740 gatccccggg aattgccatg ttacctattg gcaggatctt cttga 45 <210> 741 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 741 gatccccggg aattgccatg ttacaatttg aatttaaacc ttttttcc 48 <210> 742 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 742 gatccccggg aattgccatg ctacatgtta agttcttgtt cctcc 45 <210> 743 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 743 gatccccggg aattgccatg ttatatactc aatccaaaac agggaa 46 <210> 744 <211> 45 <212> DNA <213> Artificial Sequence Page 638 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <223> primer reverse <400> 744 gatccccggg aattgccatg tcatacgact acttgaatag attcg 45 <210> 745 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 745 gatccccggg aattgccatg ttaattatgg cctaaaactc tcgac 45 <210> 746 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 746 gatccccggg aattgccatg ttagtcattg ttgtaagtgt tctgc 45 <210> 747 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 747 gatccccggg aattgccatg ttacaaataa tcgtcaatgt tgggg 45 <210> 748 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 748 gatccccggg aattgccatg ctaaataaac tgtcccctga ttctt 45 <210> 749 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 749 gatccccggg aattgccatg ctatactggc aagtgacagt tgtg 44 <210> 750 <211> 47 <212> DNA <213> Artificial Sequence <220> Page 639 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <223> primer reverse <400> 750 gatccccggg aattgccatg ttaatcgaaa attctatgaa aaaaccc 47 <210> 751 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 751 gatccccggg aattgccatg tcagaaacgc tccactttac ttcg 44 <210> 752 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 752 gatccccggg aattgccatg ttactcgctc ttttttgagt tacatg 46 <210> 753 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 753 gatccccggg aattgccatg ctaattcctg atgccaagta acga 44 <210> 754 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 754 gatccccggg aattgccatg ttagtggaaa aacttcttca tcttttc 47 <210> 755 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 755 gatccccggg aattgccatg ttagtatcta aatggttgag agtatg 46 <210> 756 <211> 40 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 756 Page 640 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt gatccccggg aattgccatg ctactcgccc cccagcagag 40 <210> 757 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 757 gatccccggg aattgccatg ttagaaggtc gagttcaaaa tattct 46 <210> 758 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 758 gatccccggg aattgccatg ttaagcgtat tcgttaacat taacga 46 <210> 759 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 759 gatccccggg aattgccatg ttagacaaca atttcagatt ctatgg 46 <210> 760 <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 760 gatccccggg aattgccatg ttaatggcag gcgagggagc tg 42 <210> 761 <211> 49 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 761 gatccccggg aattgccatg ctagtataaa tttaagtaat ctttcatat 49 <210> 762 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 762 gatccccggg aattgccatg ttattgcccc gttgcccatt gtg 43 Page 641 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 763 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 763 gatccccggg aattgccatg ttagaagtca tcatcaaagt taatttc 47 <210> 764 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 764 gatccccggg aattgccatg ttaattcttc atcaatgcct ttagatt 47 <210> 765 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 765 gatccccggg aattgccatg ttatagttgt tcatattcat cagggt 46 <210> 766 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 766 gatccccggg aattgccatg tcaattcctt ttttttggag gaggt 45 <210> 767 <211> 41 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 767 gatccccggg aattgccatg tcacgcagac atgcgactgc g 41 <210> 768 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 768 gatccccggg aattgccatg ttacatttca ttcatttttt ttctctga 48 <210> 479 Page 642 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 42 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 769 gatccccggg aattgccatg ctaagtacgg ccggaagaga gc 42 <210> 770 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 770 gatccccggg aattgccatg ttacacagtt tccaagactt cgtc 44 <210> 771 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 771 gatccccggg aattgccatg ctacttccaa acaactggtc caga 44 <210> 772 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 772 gatccccggg aattgccatg ttatactaat ttatgatcac cgtcgg 46 <210> 773 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 773 gatccccggg aattgccatg ttattttctg tatctccaca aggac 45 <210> 774 211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 774 gatccccggg aattgccatg ctaggcaaat gccaaagatt tctta 45 <210> 775 <211> 44 Page 643 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 775 gatccccggg aattgccatg ctagtctcta tttcttccgg gaac 44 <210> 776 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 776 gatccccggg aattgccatg ctagtccttt ttcgagctcc agaa 44 <210> 777 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 777 gatccccggg aattgccatg ctaagtttca ttctcactat cactg 45 <210> 778 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 778 gatccccggg aattgccatg ctacattctc attgtggttt ctaag 45 <210> 779 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 779 gatccccggg aattgccatg ttaatcataa atagtttcat aagtgtgt 48 <210> 780 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 780 gatccccggg aattgccatg tcacttccta tgcaaaatgc ttaata 46 <210> 781 <211> 42 <212> DNA <213> Artificial Sequence Page 644 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <223> primer reverse <400> 781 gatccccggg aattgccatg tcagtcatgg catgccttgg ca 42 <210> 782 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 782 gatccccggg aattgccatg ctaaaatgaa gacagccaca atctg 45 <210> 783 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 783 gatccccggg aattgccatg ctattgattg tttgttccac ggact 45 <210> 784 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 784 gatccccggg aattgccatg ttatgaagtc catggtaaat tcgtg 45 <210> 785 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 785 gatccccggg aattgccatg ttacatgagg ttcatgttca tgttag 46 <210> 786 <211> 49 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 786 gatccccggg aattgccatg ttatttttta cttaatttca tccatttag 49 <210> 787 <211> 48 <212> DNA <213> Artificial Sequence <220> Page 645 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <223> primer reverse <400> 787 gatccccggg aattgccatg ttatgtatca caactattaa attcagtt 48 <210> 788 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 788 gatccccggg aattgccatg ttaatctctt tcaaaacaga cagcaa 46 <210> 789 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 789 gatccccggg aattgccatg ctatttttca ctttggctgt tgcc 44 <210> 790 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 790 gatccccggg aattgccatg ttaactctct tgtcccgatt tctc 44 <210> 791 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 791 gatccccggg aattgccatg ttagtttctc aagtgactat tgtgaa 46 <210> 792 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 792 gatccccggg aattgccatg ttacgaatca gtccgattgg actt 44 <210> 793 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse Page 646 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <400> 793 gatccccggg aattgccatg ttaagctgga agagccaatc tctt 44 <210> 794 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 794 gatccccggg aattgccatg ttatttcaaa gtcttcaaca atttttct 48 <210> 795 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 795 gatccccggg aattgccatg ttagtcttca tgcttatcac agaac 45 <210> 796 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 796 gatccccggg aattgccatg tcacttcaaa gtctctggaa tatga 45 <210> 797 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 797 gatccccggg aattgccatg ttattcgtct tcttccaaag tttgag 46 <210> 798 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 798 gatccccggg aattgccatg ctatgagcga tcccgttttg tgaa 44 <210> 799 <211> 50 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 799 gatccccggg aattgccatg ttaataattg aatttaattt tacttctgtt 50 Page 647 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 800 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 800 gatccccggg aattgccatg tcaccgactc attttgttaa gcttg 45 <210> 801 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 801 gatccccggg aattgccatg ttactcatct tcatagacgt ggaag 45 <210> 802 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 802 gatccccggg aattgccatg ctaacatttc ttattatctc tatatatc 48 <210> 503 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 803 gatccccggg aattgccatg ctaactgctt ttttcgtgtt gagta 45 <210> 804 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 804 gatccccggg aattgccatg tcatttttgt ccctttatat caattttt 48 <210> 805 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 805 gatccccggg aattgccatg ttagcgtttt tttttgccct tcttc 45 Page 648 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 806 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 706 gatccccggg aattgccatg ctaaatttcc aaaccattta gaacttt 47 <210> 707 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 707 gatccccggg aattgccatg ctaagacttg aaattaatta attcggg 47 <210> 808 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 808 gatccccggg aattgccatg tcactgtatc tcgctgtcac aatc 44 <210> 809 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 809 gatccccggg aattgccatg ctattgtaat tcccttatag tgttca 46 <210> 810 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 810 gatccccggg aattgccatg ttatttaagc tcgaaatggc tattga 46 <210> 811 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 811 gatccccggg aattgccatg tcattgtgga agaggtcttc tagg 44 <210> 812 <211> 45 Page 649 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 812 gatccccggg aattgccatg ttacatacca ttccaaggta acgaa 45 <210> 813 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 813 gatccccggg aattgccatg ctatatattg aagccgctga ggtc 44 <210> 814 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 814 gatccccggg aattgccatg ctacttacgt actaaaatag tctctt 46 <210> 815 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 815 gatccccggg aattgccatg ttactgagcc agtaaatacg ttcct 45 <210> 816 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 816 gatccccggg aattgccatg ctaagccaaa gtggcgttat ataac 45 <210> 817 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 817 gatccccggg aattgccatg tcatcttcga agataagggg tattc 45 <210> 818 <211> 45 <212> DNA <213> Artificial Sequence Page 650 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <220> <223> primer reverse <400> 818 gatccccggg aattgccatg ttactcaaca ggggttttta acaca 45 <210> 819 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 819 gatccccggg aattgccatg ttattttggt atcacatcat cggag 45 <210> 820 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 820 gatccccggg aattgccatg tcaatttgct ataggctgta gcgg 44 <210> 821 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 821 gatccccggg aattgccatg ttagaactga attatttcac attgtct 47 <210> 822 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 822 gatccccggg aattgccatg ttacattggg aagggcatct gaga 44 <210> 823 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 823 gatccccggg aattgccatg ttacagtttt tgtttagtcg ttttaac 47 <210> 824 <211> 45 <212> DNA <213> Artificial Sequence <220> Page 651 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <223> primer reverse <400> 824 gatccccggg aattgccatg ttattcatcc ttccaaccca acttt 45 <210> 825 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 825 gatccccggg aattgccatg tcattgtctc aaaacatctt cgatg 45 <210> 826 <211> 47 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 826 gatccccggg aattgccatg ttatttttca tcagatactg ataaggt 47 <210> 827 <211> 43 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 827 gatccccggg aattgccatg tcaatgctca tccatgagcg cca 43 <210> 828 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 828 gatccccggg aattgccatg ctaaaatatg gaggaactag gtttaa 46 <210> 829 <211> 35 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 829 ttgctcttcg ttaaactgat ggacgcaaac gaacg 35 <210> 830 <211> 36 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 830 Page 652 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt ttgctcttcg ttatttctta cgcgcgtatt tcagtg 36 <210> 831 <211> 35 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 831 ttgctcttcg ttagctgaac agagagtaga agatt 35 <210> 832 <211> 34 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 832 ttgctcttcg ttacatccac ataatttgct gccc 34 <210> 833 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 833 ttgctcttcg ttacttcaca tcatccggca gcg 33 <210> 834 <211> 37 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 834 ttgctcttcg ttaaaacagt ttgtatacga tgttcag 37 <210> 835 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 835 ttgctcttcg ttacttgacg ggagcgggtt gt 32 <210> 836 <211> 34 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 836 ttgctcttcg ttaactcgcc gtttcaggct taaa 34 Page 653 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 837 <211> 31 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 837 ttgctcttcg ttaattgcca gccatcgcct g 31 <210> 838 <211> 33 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 838 ttgctcttcg ttaccaggcg gtatggtaaa gct 33 <210> 839 <211> 38 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 839 ttgctcttcg ttaattaatc attgagttaa gttgaaga 38 <210> 840 <211> 32 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 840 ttgctcttcg ttaatcgcgg ctagcgaagc cc 32 <210> 841 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 841 gatccccggg aattgccatg ctaatttggt tccacaaagg ctcta 45 <210> 842 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 842 gatccccggg aattgccatg tcagtcgtat tcttggagac agtc 44 Page 654 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <210> 843 <211> 45 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 843 gatccccggg aattgccatg ttagtcgtcg tagttttcat cttct 45 <210> 844 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 844 gatccccggg aattgccatg tcacaagttt tccagagatg cagc 44 <210> 845 <211> 48 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 845 gatccccggg aattgccatg tcattttgtt aatagttttt tgtatgct 48 <210> 846 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 846 gatccccggg aattgccatg ttatttcttg ggtataactg tcagtc 46 <210> 847 <211> 44 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 847 gatccccggg aattgccatg tcacaactcg ccgaattcat cgta 44 <210> 848 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 848 gatccccggg aattgccatg ttataaaatt atgcaacagt tagccc 46 <210> 849 Page 655 2012201983 05 Apr 2012 20051006 e pf54437-SEQUENCES LISTING 949788.txt <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 849 gatccccggg aattgccatg ctatttcaat gaaccagttt ggaatc 46 <210> 850 <211> 46 <212> DNA <213> Artificial Sequence <220> <223> primer reverse <400> 850 gatccccggg aattgccatg ctagttgtcg tattcttcct taatta 46 PF54437 PCT/US2004/011888 WO2004/092349 1065/1065 Page 656 2012201983 05 Apr 2012