AU2011100917A4 - Treatment of male and female androgenetic alopecia with oral minoxidil either alone or in combination with antiandrogens - Google Patents
Treatment of male and female androgenetic alopecia with oral minoxidil either alone or in combination with antiandrogens Download PDFInfo
- Publication number
- AU2011100917A4 AU2011100917A4 AU2011100917A AU2011100917A AU2011100917A4 AU 2011100917 A4 AU2011100917 A4 AU 2011100917A4 AU 2011100917 A AU2011100917 A AU 2011100917A AU 2011100917 A AU2011100917 A AU 2011100917A AU 2011100917 A4 AU2011100917 A4 AU 2011100917A4
- Authority
- AU
- Australia
- Prior art keywords
- daily
- minoxidil
- antiandrogens
- alone
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title claims abstract description 20
- 229960003632 minoxidil Drugs 0.000 title claims abstract description 20
- 201000004384 Alopecia Diseases 0.000 title abstract description 6
- 230000002280 anti-androgenic effect Effects 0.000 title abstract description 5
- 239000000051 antiandrogen Substances 0.000 title abstract description 5
- 206010068168 androgenetic alopecia Diseases 0.000 title abstract description 3
- 201000002996 androgenic alopecia Diseases 0.000 title abstract description 3
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 title abstract description 3
- 238000011282 treatment Methods 0.000 title description 3
- 239000002775 capsule Substances 0.000 claims abstract description 17
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 claims description 8
- 229960002074 flutamide Drugs 0.000 claims description 8
- 229960004199 dutasteride Drugs 0.000 claims description 5
- JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 claims description 5
- 229960004039 finasteride Drugs 0.000 claims description 5
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 abstract description 4
- 208000024963 hair loss Diseases 0.000 abstract description 3
- 230000003676 hair loss Effects 0.000 abstract description 3
- 206010020864 Hypertrichosis Diseases 0.000 abstract description 2
- 208000001953 Hypotension Diseases 0.000 abstract description 2
- 206010047141 Vasodilatation Diseases 0.000 abstract description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
- 230000036543 hypotension Effects 0.000 abstract description 2
- 210000004761 scalp Anatomy 0.000 abstract description 2
- 230000024883 vasodilation Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000003779 hair growth Effects 0.000 abstract 1
- 229960000978 cyproterone acetate Drugs 0.000 description 2
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 description 2
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 2
- 229960002256 spironolactone Drugs 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- 229940124563 hair growth stimulant Drugs 0.000 description 1
- 230000003659 hair regrowth Effects 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Abstract Low dose oral minoxidil can be compounded into capsules and used either alone or in combination with oral antiandrogens therapy to promote scalp hair growth in androgenetic alopecia and other hair loss related disorders without usual side-effects vasodilatation, hypotension and hypertrichosis associated with standard doses.
Description
1 Description Oral minoxidil is a potent hair growth stimulant. Standard doses are associated with vasodilatation, hypotension and hypertrichosis. Low dose oral minoxidil can be compounded into capsules and used either alone or in combination with oral antiandrogens therapy to promote scalp hair regrowth in androgenetic alopecia and other hair loss related disorders. In males it can be used together with finasteride, dutasteride or other antiandrogen treatments. In females it can be used together with spironolactone, cyproterone acetate, flutamide and other antiandrogen therapies. Doses of oral minoxidil that have been tried in both men and women with hair loss include 0.5 mg daily, 1 mg daily, 2 mg daily, 2.5 mg daily, 3 mg daily, 5 mg daily and 10 mg daily. Other doses within this range are also likely to be effective. Doses of finasteride that have been tried in men include 0.5 mg daily, 1mg daily, 5 mg daily and 5 mg weekly. Dose of dutasteride that have been tried in men include 0.5mg daily ad 1 mg daily and 0.5 mg weekly. Doses of spironolactone that have been tried include 25 mg daily, 50 mg daily, 100mg daily, 200 mg daily, 300 mg daily and 400 mg daily. Doses of flutamide that have been tried include 25 mg daily, 50 mg daily, 62.5 mg daily, 100 mg daily, 125 mg daily, 250 mg daily and 500 mg daily. Doses of cyproterone acetate that have been tried include 2mg daily, 25 mg daily, 50 mg daily and 100 mg daily. These can also be combined with oral contraceptive therapy to minimize the risk of unplanned pregnancy while on this treatment.
Claims (1)
- 2.5mg minoxidil capsule 5mg minoxidil capsule 10mg minoxidil capsule 1mg minoxidil, 1mg finasteride capsule 1mg minoxidil 0.5 mg dutasteride capsule 1mg minoxidil 50 mg flutamide capsule 1mg minoxidil 62.5 mg flutamide capsule 2mg minoxidil, 1mg finasteride capsule 2mg minoxidil 0.5 mg dutasteride capsule 2mg minoxidil 50 mg flutamide capsule 2mg minoxidil 62.5 mg flutamide capsule 2.5mg minoxidil, 1mg finasteride capsule 2.5mg minoxidil 0.5 mg dutasteride capsule 2.5mg minoxidil 50 mg flutamide capsule 2.5mg minoxidil 62.5 mg flutamide capsule
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011100917A AU2011100917B4 (en) | 2011-07-26 | 2011-07-26 | Treatment of male and female androgenetic alopecia with oral minoxidil either alone or in combination with antiandrogens |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2011100917A AU2011100917B4 (en) | 2011-07-26 | 2011-07-26 | Treatment of male and female androgenetic alopecia with oral minoxidil either alone or in combination with antiandrogens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2011100917A4 true AU2011100917A4 (en) | 2011-09-01 |
| AU2011100917B4 AU2011100917B4 (en) | 2013-05-02 |
Family
ID=45421166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011100917A Expired AU2011100917B4 (en) | 2011-07-26 | 2011-07-26 | Treatment of male and female androgenetic alopecia with oral minoxidil either alone or in combination with antiandrogens |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2011100917B4 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3019045A1 (en) * | 2014-03-26 | 2015-10-02 | Greenpharma Sas | DERMATOLOGICAL COMPOSITION FOR THE REPELLENT OF HAIR OR HAIR |
| EP3209275A4 (en) * | 2014-10-24 | 2018-04-11 | Beautopia LLC | Combined hair loss inhibition treatment |
| US10226462B2 (en) | 2014-10-29 | 2019-03-12 | Samson Clinical Pty Ltd | Detection and treatment of excessive hair shedding |
| CN111065396A (en) * | 2017-07-12 | 2020-04-24 | 萨姆森临床私人有限公司 | Promotes hair growth and treats hair loss or excessive hair loss |
| WO2023055740A1 (en) * | 2021-09-29 | 2023-04-06 | Nirmana Bio, Inc. | Hair loss therapy |
| US12268688B2 (en) | 2022-10-25 | 2025-04-08 | Veradermics Incorporated | Compositions and methods of use for modified release minoxidil |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674762A (en) * | 2019-03-05 | 2019-04-26 | 南京正大天晴制药有限公司 | A kind of composition capsule of dutasteride and hair growth |
-
2011
- 2011-07-26 AU AU2011100917A patent/AU2011100917B4/en not_active Expired
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3019045A1 (en) * | 2014-03-26 | 2015-10-02 | Greenpharma Sas | DERMATOLOGICAL COMPOSITION FOR THE REPELLENT OF HAIR OR HAIR |
| IL251862B1 (en) * | 2014-10-24 | 2023-05-01 | Beautopia Llc | Combined hair loss inhibition treatment |
| EP3209275A4 (en) * | 2014-10-24 | 2018-04-11 | Beautopia LLC | Combined hair loss inhibition treatment |
| US10195199B2 (en) | 2014-10-24 | 2019-02-05 | Beautopia Llc | Combined hair loss inhibition treatment |
| US10744138B2 (en) | 2014-10-24 | 2020-08-18 | Garuhda Llc | Combined hair loss inhibition treatment |
| IL251862B2 (en) * | 2014-10-24 | 2023-09-01 | Beautopia Llc | Combined hair loss inhibition treatment |
| US10226462B2 (en) | 2014-10-29 | 2019-03-12 | Samson Clinical Pty Ltd | Detection and treatment of excessive hair shedding |
| US20190192513A1 (en) * | 2014-10-29 | 2019-06-27 | Samson Clinical Pty Ltd | Detection and Treatment of Excessive Hair Shedding |
| EP3626244A1 (en) * | 2014-10-29 | 2020-03-25 | Samson Clinical Pty Ltd. | Oral minoxidil for the treatment of alopecia areata |
| US11116770B2 (en) | 2014-10-29 | 2021-09-14 | Samson Clinical Pty Ltd | Detection and treatment of excessive hair shedding |
| CN115998740A (en) * | 2014-10-29 | 2023-04-25 | 萨姆森临床私人有限公司 | Detection and treatment of excessive hair loss |
| CN111065396A (en) * | 2017-07-12 | 2020-04-24 | 萨姆森临床私人有限公司 | Promotes hair growth and treats hair loss or excessive hair loss |
| WO2023055740A1 (en) * | 2021-09-29 | 2023-04-06 | Nirmana Bio, Inc. | Hair loss therapy |
| US12268688B2 (en) | 2022-10-25 | 2025-04-08 | Veradermics Incorporated | Compositions and methods of use for modified release minoxidil |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011100917B4 (en) | 2013-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGI | Letters patent sealed or granted (innovation patent) | ||
| FF | Certified innovation patent | ||
| MK22 | Patent ceased section 143a(d), or expired - non payment of renewal fee or expiry |