AU2010347608A1 - Apparatus for the weight-compensating movable suspension of a focussing objective of a laser device - Google Patents

Apparatus for the weight-compensating movable suspension of a focussing objective of a laser device Download PDF

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AU2010347608A1
AU2010347608A1 AU2010347608A AU2010347608A AU2010347608A1 AU 2010347608 A1 AU2010347608 A1 AU 2010347608A1 AU 2010347608 A AU2010347608 A AU 2010347608A AU 2010347608 A AU2010347608 A AU 2010347608A AU 2010347608 A1 AU2010347608 A1 AU 2010347608A1
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objective
rocker
focussing
focussing objective
guidance
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AU2010347608B2 (en
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Gerhard Robl
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Alcon Inc
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Wavelight GmbH
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F9/00825Methods or devices for eye surgery using laser for photodisruption
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50Supports for surgical instruments, e.g. articulated arms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/50Supports for surgical instruments, e.g. articulated arms
    • A61B2090/5025Supports for surgical instruments, e.g. articulated arms with a counter-balancing mechanism
    • A61B2090/504Supports for surgical instruments, e.g. articulated arms with a counter-balancing mechanism with a counterweight
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007Methods or devices for eye surgery
    • A61F9/008Methods or devices for eye surgery using laser
    • A61F2009/00861Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872Cornea

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  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Laser Surgery Devices (AREA)
  • Microscoopes, Condenser (AREA)
  • Radiation-Therapy Devices (AREA)
  • Optical Couplings Of Light Guides (AREA)
  • Lenses (AREA)
  • Telescopes (AREA)
  • Optical Communication System (AREA)
  • Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)

Abstract

An apparatus for the weight-compensating movable suspension of a focussing objective (12) of a laser device (10) comprises a force generating arrangement for generating a counterforce component (G) counteracting the weight force of the focussing objective (12), a transmitting arrangement that transmits the counterforce component (G) to the focussing objective (12) and as an up/down compensation movement of the focussing objective, and a guide arrangement for movably guiding the focussing objective, in such a way that during an up/down compensation movement of the focussing objective (12) an optical axis (O) thereof maintains at least its spatial orientation and preferably its spatial position.

Description

1OA-119 113 Apparatus for the weight-compensating movable suspension of a focussing objective of a laser device The invention concerns movable weight-compensating suspension of a focussing s objective of a laser system. The laser system preferably provides pulsed laser radia tion, which is focussed by means of the focussing objective onto a desired location where the radiation is to act. Movable weight-compensating suspension of the focussing objective is desired, not 10 exclusively but above all, where treatment of living tissue is involved, and there is direct contact between the tissue and the laser system. Such direct contact is often produced, for example, in the case of operations on the human eye using laser sur gery, when incisions in the cornea or other parts of the eye are to be made using ultra-short pulses of laser radiation. In this case, direct contact is intended to ensure is precise positioning of the eye to be treated relative to the laser system in the direc tion of propagation of the radiation. Usually, a suitable interface unit (patient adapt er) is connected in front of the focussing objective, and effects the physical coupling of the eye to the laser system. The interface unit usually has a holder, which is cou pled to the focussing objective, for a contact element which is to be brought into 20 contact with the eye and is made of a material which is transparent to the laser ra diation. The contact element can, for example, be a plane underside for applanation of the cornea. Focussing objectives in laser systems are often multi-lens systems, which can put 2s considerable weight on the scales. Several kilograms are not unusual for such focus sing objectives. Obviously, in an eye operation the full weight of the focussing objec tive must not rest on the eye being treated. Weight-compensating suspension for the focussing objective is therefore provided. The force which the focussing objective still exerts on the eye in the case of such a weight-compensating solution is reduced to a 30 few newtons (e.g. 1 to 2 N), for example. This makes it possible to deflect the focus sing objective upward, gently and not dangerously to the eye, if the patient suddenly happens to raise his or her head involuntarily, e.g. in a panic reaction. An example of weight-compensating suspension of a focussing objective is given in 35 US 5,336,215. There the weight of the objective is compensated for by a spring system, by means of which the objective is movably suspended in a frame relative to the latter.
1OA-119 113 -2 It is an object of the invention to give a reliably and precisely functioning solution for weight compensation of a focussing objective in a laser system. 5 According to the invention, for this purpose movable weight-compensating suspen sion of a focussing objective of a laser system is provided, comprising: - a force generation device to generate a counterforce component which counteracts the weight of the focussing objective, - a transmission device which transmits the counterforce component onto the focus 10 sing objective and permits upward/downward compensatory movement of the focus sing objective, and - a guidance device for movable guidance of the focussing objective, in such a way that in the case of an upward/downward compensatory movement of the focussing objective, an optical axis of the focussing objective maintains at least its orientation is in space, and preferably its position in space. Guidance of the focussing objective through the guidance device prevents undesired tilting of the optical axis of the objective in the case of an upward/downward com pensatory movement of the objective. "Upward/downward compensatory movement" 20 is understood here as a movement of the focussing objective upward or downward relative to the laser system. Thus despite a compensatory movement of the objec tive, the optical axis remains in a specified orientation to the object which is being treated, e.g. to the optical axis of a human eye which is being treated. It should be pointed out here that the invention can in principle be used with laser systems for 2s any application purposes, and in particular for working on any materials (including dead matter), and is by no means restricted to ophthalmological application pur poses. The force generation device can include a counterweight, the mass of which is used 30 to generate at least part, and in particular the whole, of the counterforce component. The counterweight can consist of a single counterweight member, or alternatively can consist of multiple (at least two) individual weight members, which for example can be used in changeable numbers or/and in changeable position relative to each other. The individual weight members can also be combined into a single total 35 weight, and taken individually out of the total weight. By such variabilities of the counterweight, specially precise taring of the weight compensation is possible.
1OA-119 113 -3 Moreover, within the invention, generating part of the counterforce component by means of at least one elastic element should not be excluded. Because of the disad vantage, which is often associated with elastic elements, that the effective force depends on the distance (the elasticity depends on the state of deformation of the 5 elastic element), the force generation device preferably does not generate the coun terforce component exclusively by means of elastic elements. However, combining one or more elastic elements with a counterweight is also conceivable, e.g. to im plement a desired force-distance dependency intentionally. .0 The transmission device is preferably in the form of a rocker, on one side of which the counterforce component acts, and on the other side of which the weight of the focussing objective acts. Functionally, the rocker can be compared with a weighing beam. i5 For example, the rocker is formed of at least one lever body, one lever arm of which is connected to the focussing objective, and the other lever arm of which is con nected to the force generation device. It is understood that two or more such lever bodies can be provided adjacently, parallel and at a distance, to form the rocker. A force application point of the force generation device on the lever body can be 20 adjustable along it, so as to adjust the torque acting on the lever body. In general, preferably at least one force application point of the force generation device on the rocker can be adjusted with respect to its distance from a swivelling axis of the rocker. Use of a counterweight which is applied on one side of the rocker (i.e. on one lever 25 arm) to generate at least part of the counterforce component has the advantage of the maximum possible constancy of the generated counterforce component over the whole operationally required movement travel of the focussing objective. By inten tional displacement of the centre of gravity of the counterweight relative to the rocker, the force-distance characteristic curve of the suspension apparatus can be set 30 definitively. This makes taring possible even with an indivisible counterweight. On the other hand, if the force generation device includes at least one elastic element, the force-distance characteristic curve of the suspension apparatus can be set in addition to the typically spring-like force-distance characteristic of the elastic ele ment, because the force application point of the elastic element is movable along the 35 lever or along the rocker.
1OA-119 113 -4 The focussing objective is preferably supported on the rocker so that it can rotate relative to the rocker around an axis of rotation which runs parallel to a swivelling axis of the rocker at a distance. It is recommended, for spatial positional stability of the optical axis of the objective, that the support of the focussing objective on the 5 rocker is at a variable distance to the swivelling axis of the rocker. If the rocker is tilted, the focussing objective can then carry out a simultaneous movement, meaning a change of distance from the rocker axis. In this way the objective can move up and down along a straight line instead of along a circular path, i.e. it maintains its trans verse position (transverse means orthogonal to the objective axis) relative to the 1o object being worked on. The swivelling bearing of the rocker is preferably of low-friction form, and can for example be implemented by means of a plastic sliding bearing or a rolling bearing. Low friction is a desirable aim, to avoid, as far as possible, falsification of the effec i5 tive force-distance characteristic of the suspension apparatus by overlaid friction forces. In a preferred embodiment, the focussing objective is supported on a supporting surface arrangement of the rocker so that it can move freely. In particular, the sup 20 porting surface arrangement can be in such a form that the objective can be placed loosely on the rocker. The supporting surface arrangement can, for example, be formed of at least one longitudinal recess - into which the objective can be inserted with a suitable supporting pin or other supporting formation - of at least one lever body of the rocker. For example, the recess can be open upward, or/and it can - in 25 relation to the longitudinal extent of the relevant lever arm, on which the objective grips - be open to the front or rear, so that the supporting formation of the objective can be inserted from the front or rear into the recess. It is understood that the supporting surface arrangement can alternatively, for ex 30 ample, be in the form of an arrangement of one or more enclosed long holes, the objective engaging with each long hole by a suitable supporting projection. It is also understood that according to a modification, the supporting surface arrangement can be formed on the objective, and suitable supporting formations for support on the supporting surface arrangement can be formed on the rocker. 35 In any case, the support of the objective on the rocker is preferably such that not only rotation of the objective relative to the rocker in the course of a swivelling 1OA-119 113 -5 movement of the rocker is made possible, but also a radial change of the distance between the axis of rotation of the objective and the rocker axis (radially in relation to the rocker axis). 5 The guidance device is preferably in the form of a linear guide with a parallel guid ance direction to the optical axis of the focussing objective. It preferably has guid ance formations which prevent movements of the focussing objective transversely to the optical axis in the case of an upward/downward compensatory movement of the focussing objective. This is useful for stabilising the position of the objective in space. l0 For example, the guidance device can include a linear bearing and a slide which is guided in it. The slide can be fixed on the focussing objective. The linear bearing can also include at least one guidance groove. The slide can also include at least one guidance projection, which is set up to work with the guidance groove in such a way is that movement of the slide in a horizontal direction is avoided. In this way, guidance of the focussing objective in a vertical direction is made possible, the optical axis of the focussing objective being able to maintain its alignment and position in the case of a compensatory movement of it relative to an initial position. For this purpose, the guidance groove can be formed with an undercut, into which the guidance projection 20 engages. According to another point of view, the invention provides a laser system, compris ing: - a laser radiation source, preferably of pulsed laser radiation, 25 - a focussing objective for focussing the laser radiation, the focussing objective hav ing an optical axis, - an interface unit, which is arranged on the radiation exit side of the focussing ob jective and is preferably separably coupled to it, with a contact element, which is transparent to the laser radiation, for placing on an object on which work is to be 30 done using the laser radiation, - a suspension apparatus, in particular of the type described above, for movable weight-compensating suspension of the focussing objective, this apparatus having a rocker, with two rocker arms, which is supported on a housing member so that it can be swivelled around a rocker axis of the laser system, the focussing objective being 35 supported on one of the rocker arms so that it can rotate relative to the rocker around a parallel axis of rotation to the rocker axis, and on the other rocker arm a counterweight to generate a counterforce component which compensates for at least 1OA-119 113 -6 a predominant part of the weight of the focussing objective being attached, and the apparatus also having a guidance system for linearly movable guidance of the focus sing objective along the optical axis thereof. s The invention is further explained below, on the basis of the attached drawing. Fig. 1 shows, schematically and not at all to scale, an embodiment of a laser system for making incisions in the cornea or other tissue parts of a human eye. Of the laser system, which as whole is marked with 10, only the "output stage" is 10 shown in the drawing, i.e. essentially only a focussing objective 12 with a patient adapter 13 arranged on the radiation exit side of it. The focussing objective 12 is weight-compensated and movably suspended by a suspension apparatus 14. If "weight compensation" is mentioned here, it means compensation for at least a pre dominant part of the weight of the objective 12. A particularly small residual part of i5 the objective weight can remain without compensation, e.g. of the order of magni tude of a few newtons of weight. The focussing objective 12 focusses, in a way which is not shown in more detail, an afocal beam of rays of the laser radiation pro vided by the laser system 10 onto a focus location within the eye tissue to be cut. The laser radiation which is used has, for example, pulse durations in the femtosec 20 ond range, and a wavelength in the low infrared range (e.g. between approx. 1000 and approx. 1100 nm), or in the UV range, preferably above about 300 nm. The suspension apparatus 14, in the shown embodiment of Fig. 1, has a force gen eration arrangement with a counterweight 16, which generates a vertically directed 2s weight component G, with which it is intended that the weight of the focussing objective 12 should be at least partly compensated for. The suspension apparatus 14 also includes a transmission arrangement in the form of a rocker 18, which at its right-hand end in Fig. 1 is separably joined to the counterweight 16, whereas at its other, left-hand end in Fig. 1 it has a bearing seat 20 for separable coupling with the 30 focussing objective 12. The counterweight 16 can be shifted along the appropriate lever arm of the rocker, so that the effective force application point K of the coun terweight, and thus the effective counterforce moment, can be changed. The rocker 18 is carried by a bearing 22 so that it can rotate around a swivelling axis 35 X at a distance between the points of application of the objective 12 and of the coun terweight 16. The bearing 22 supports the rocker 18, via one or more connecting 10A-119 113 -7 cheeks 21, on a schematically indicated supporting part 23, which itself can be ar ranged stationarily or movably relative to other components of the laser system 10. The rocker 18 can have, for example, an oblong, in particular essentially straight 5 lever rod 19, which at one of its ends is coupled to the objective 12, and at its other end is coupled to the counterweight 16. Purposefully, two such lever rods 19 are provided, parallel to each other, on both sides of the objective 12 (i.e. behind and in front of the objective 12 in the viewing direction of Fig. 1). However, in the further description only one lever rod will be mentioned, but the following explanations apply t0 analogously to both lever rods. In the shown example, the above-mentioned bearing seat 20 is formed by a laterally made recess 24 of the lever rod 19 (indicated by a dotted line), which is open on more than one side, that is upward and to the left in the figure. The floor 24a of this is recess 24 forms a supporting surface for a vertical journal 26 which stands laterally away from the objective 12 and projects into the recess. The focussing objective 12 rests loosely on the lever rod 19 via its vertical journal 26. If the rocker 18 is swiv elled, not only is the objective 12 rotated around the journal axis relative to the rock er 18, but also the vertical journal 26 is displaced within the bearing seat 20. With 20 this displacement, the radial distance of the vertical journal 26 from the swivelling axis X changes. This makes it possible, despite upward or downward movement of the objective 12, to keep the position and orientation of an optical objective axis 0 in space unchanged. So that the displacement of the vertical journal 26 in the bearing seat 20 takes place without friction as far as possible, for example the vertical journal 2s 26 can carry a ring 28, which can roll on the floor 24a of the recess 24, on a sliding or rolling bearing. The suspension apparatus 14 also includes a guidance system for vertical linear guidance of the focussing objective 12. Whereas the possibility of displacing the 30 vertical journal 26 in the bearing seat 20 creates the precondition for a constant position in space of the objective axis 0 when the objective 12 moves, the guidance system ensures that the objective axis 0 is actually not tilted or displaced trans versely (to the axis 0). 35 The guidance system, in the shown embodiment, includes a linear bearing 30 which is fixed relative to the focussing objective 12, and a slide 32 which is guided on it and fixed on the focussing objective 12. The linear bearing 30 is provided with a guidance 1OA-119 113 -8 groove 34, which is in the form of an undercut and engages with a guidance projec tion 36 of the slide 32. The guidance projection 36 is T-shaped in cross-section in the embodiment shown in Fig. 1, the two T side arms 36a of the guidance projection 36 engaging with the undercut guidance groove 34 in such a way that a horizontal s (transverse) movement of the focussing objective 12 away from the linear bearing 30 (to the right in Fig. 1) is prevented. Additionally, the engagement of the T side arms 36a with the undercut guidance groove 34 ensures that the focussing objective 12 does not tilt. It is always held by the guidance arrangement in a specified orientation. 10 The engagement of the guidance projection 36 with the guidance groove 34 provides sufficient vertical play to ensure the necessary movement travel of the focussing objective 12 in the vertical direction. If the focussing objective 12, with its patient adapter 13, is placed on the eye (not is shown) to be treated, the focussing objective 12 can be deflected vertically upward by a slight counter-pressure caused by the eye. In the case of this compensatory movement of the focussing objective 12, the vertical journal 26 shifts by rolling (or alternatively sliding) along the floor 24a of the recess 24, while the rocker 18 rotates clockwise around the rocker axis X, and simultaneously the objective 12 rotates rela 20 tive to the rocker 18 around the axis of the vertical journal 26. In contrast, if, in an imaginary hypothetical case, the focussing objective 12 was joined rigidly to the rocker 18, an upward or downward movement of the focussing objective 12 would result in tilting the optical axis 0. However, in the shown embodiment, such tilting is excluded, because of the movable support of the objective 12 on the rocker 18, and 25 because of the linear guidance of the objective 12 by the linear bearing 30.

Claims (9)

1. Apparatus for movable weight-compensating suspension of a focussing objec tive (12) of a laser system (10), comprising: 5 - a force generation device to generate a counterforce component (G ) which counteracts the weight of the focussing objective (12), - a transmission device which transmits the counterforce component (6 ) onto the focussing objective (12) and permits upward/downward compensatory move ment of the focussing objective, and 10 - a guidance device for movable guidance of the focussing objective, in such a way that in the case of an upward/downward compensatory movement of the focus sing objective (12), an optical axis (0) of the focussing objective maintains at least its orientation in space, and preferably its position in space. 15
2. Apparatus according to Claim 1, wherein the force generation device includes a counterweight (16), the mass of which is used to generate at least part, and in particular the whole, of the counter force component. 20
3. Apparatus according to Claim 1 or 2, wherein the transmission device is in the form of a rocker, on one side of which the counterforce component acts, and on the other side of which at least part of the weight of the focussing objective (12), in particular the whole weight, acts. 25
4. Apparatus according to Claim 3, wherein at least one force application point (K) of the force generation device on the rocker can be adjusted with respect to its distance from a swivelling axis (X) of the rocker. 30
5. Apparatus according to Claim 3 or 4, wherein the focussing objective (12) is supported on the rocker so that it can rotate relative to the rocker around an axis of rotation which runs parallel to a swivelling axis (X) of the rocker at a distance. 1OA-119 113 - 10
6. Apparatus according to Claim 5, wherein the support of the focussing objective (12) on the rocker is at a variable distance to the swivelling axis (X) of the rocker. s
7. Apparatus according to one of the preceding claims, wherein the guidance device is in the form of a linear guide with a parallel guidance direction to the optical axis (0) of the focussing objective (12).
8. Apparatus according to Claim 7, 10 wherein the guidance device has guidance formations which prevent movements of the focussing objective transversely to the optical axis (0) in the case of an up ward/downward compensatory movement of the focussing objective.
9. Laser system (10), comprising: 15 - a laser radiation source, preferably of pulsed laser radiation, - a focussing objective (12) for focussing the laser radiation, the focussing objective having an optical axis (0), - an interface unit, which is arranged on the radiation exit side of the focus sing objective and is preferably separably coupled to it, with a contact element, 20 which is transparent to the laser radiation, for placing on an object on which work is to be done using the laser radiation, - an apparatus, in particular in a form according to one of the preceding claims, for movable weight-compensating suspension of the focussing objective, this apparatus having a rocker, with two rocker arms, which is supported on a housing 25 member of the laser system so that it can be swivelled around a rocker axis (X), the focussing objective being supported on one of the rocker arms so that it can rotate relative to the rocker around a parallel axis of rotation to the rocker axis, and on the other rocker arm a counterweight (16) to generate a counterforce component which compensates for at least a predominant part of the weight of the focussing objective 30 being attached, and the apparatus also having a guidance system for linearly mov able guidance of the focussing objective along the optical axis thereof.
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CA2791803A1 (en) 2011-09-09
JP2013521024A (en) 2013-06-10
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CN102834755B (en) 2015-09-02
RU2012141541A (en) 2014-04-10
KR101472740B1 (en) 2014-12-15
EP2542934B1 (en) 2016-08-24
BR112012022135A2 (en) 2016-10-25
ES2598481T3 (en) 2017-01-27
CA2791803C (en) 2015-07-14
CN102834755A (en) 2012-12-19
KR20130028907A (en) 2013-03-20
AR081100A1 (en) 2012-06-13
BR112012022135B1 (en) 2019-10-22
PT2542934T (en) 2016-10-25
RU2520920C2 (en) 2014-06-27
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EP2542934A1 (en) 2013-01-09
DK2542934T3 (en) 2016-10-24

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