AU2010250104B2 - Inhibition of prion protein propagation by receptor associated protein (RAP). its derivatives, mimetics and synthetic peptides - Google Patents

Inhibition of prion protein propagation by receptor associated protein (RAP). its derivatives, mimetics and synthetic peptides Download PDF

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Publication number
AU2010250104B2
AU2010250104B2 AU2010250104A AU2010250104A AU2010250104B2 AU 2010250104 B2 AU2010250104 B2 AU 2010250104B2 AU 2010250104 A AU2010250104 A AU 2010250104A AU 2010250104 A AU2010250104 A AU 2010250104A AU 2010250104 B2 AU2010250104 B2 AU 2010250104B2
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AU
Australia
Prior art keywords
rap
seq
polypeptide
disease
prion
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010250104A
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English (en)
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AU2010250104A1 (en
AU2010250104A8 (en
Inventor
Larisa Cervenakova
Oksana Yakovleva
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American National Red Cross
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American National Red Cross
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Publication of AU2010250104A1 publication Critical patent/AU2010250104A1/en
Publication of AU2010250104A8 publication Critical patent/AU2010250104A8/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2010250104A 2009-05-21 2010-05-17 Inhibition of prion protein propagation by receptor associated protein (RAP). its derivatives, mimetics and synthetic peptides Ceased AU2010250104B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18040609P 2009-05-21 2009-05-21
US61/180,406 2009-05-21
US21875209P 2009-06-19 2009-06-19
US61/218,752 2009-06-19
PCT/US2010/001455 WO2010134970A1 (en) 2009-05-21 2010-05-17 Inhibition of prion protein propagation by receptor associated protein (rap). its derivatives, mimetics and syntentic peptides

Publications (3)

Publication Number Publication Date
AU2010250104A1 AU2010250104A1 (en) 2011-10-27
AU2010250104A8 AU2010250104A8 (en) 2012-06-07
AU2010250104B2 true AU2010250104B2 (en) 2014-04-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010250104A Ceased AU2010250104B2 (en) 2009-05-21 2010-05-17 Inhibition of prion protein propagation by receptor associated protein (RAP). its derivatives, mimetics and synthetic peptides

Country Status (6)

Country Link
US (1) US9051390B2 (enExample)
EP (1) EP2432487B1 (enExample)
JP (1) JP5862560B2 (enExample)
AU (1) AU2010250104B2 (enExample)
CA (1) CA2755948A1 (enExample)
WO (1) WO2010134970A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017218897A1 (en) * 2016-06-17 2017-12-21 The Trustees Of The University Of Pennsylvania Novel 1gg binding peptides and multifunctional antigen-binding proteins comprising the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050042227A1 (en) * 2003-06-20 2005-02-24 Todd Zankel Megalin-based delivery of therapeutic compounds to the brain and other tissues
US20080268474A1 (en) * 2002-12-03 2008-10-30 Hammond David J Prion protein ligands and methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040110938A1 (en) * 2000-02-24 2004-06-10 Parekh Rajesh Bhikhu Proteins, genes and their use for diagnosis and treatment of schizophrenia
EP1638605B1 (en) 2003-06-20 2014-01-08 Raptor Pharmaceutical, Inc. Delivery of therapeutic compounds to the brain and other tissues

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080268474A1 (en) * 2002-12-03 2008-10-30 Hammond David J Prion protein ligands and methods of use
US20050042227A1 (en) * 2003-06-20 2005-02-24 Todd Zankel Megalin-based delivery of therapeutic compounds to the brain and other tissues

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
: DATABASE UniProt [Online] 21 December 2004 (2004-12-21 ), "SubName: Full=Putative uncharacterized protein DKFZp45912430;", retrieved from EBI accession no. UNIPROT:Q5RD62 Database accession no. Q5RD62 *
DATABASE Geneseq [Online] 29 January 2004 (2004-01-29), "Rat Protein 099068, SEQ ID NO 10388.", retrieved from EBI accession no. GSP:ADD44957 Database accession no. ADD44957 *
DATABASE UniProt [Online] 1 June 1998 (1998-06-01 ), "SubName: Full=Receptor-associated protein; Flags: Precursor;", retrieved from EBI accession no. UNIPROT:O57378 Database accession no. O57378 *
DATABASE UniProt [Online] 1 June 2003 (2003-06-01 ), "SubName: Full=Low density lipoprotein receptor-related protein associated protein 1; LQWKKLKAEG MDEDGEREAK LRRNFNllLA KYGMDGKKDT RTLDSNRLKD HEVKIGDTFD", EBI Acc. No. Q7ZW96 *
DATABASE UniProt [Online] 1 October 2003 (2003-10-01 ), "SubName: Full=LOC398643 protein; Flags: Fragment;", retrieved from EBI accession no. UNIPROT:Q7SYR7 Database accession no. Q7SYR7 *
DATABASE UniProt [Online] 5 July 2004 (2004-07-05), "SubName: Full=Lrpap1 protein; Flags: Fragment;", XP002687 468, EPO Form 1703 01.91TRI retrieved from EBI accession no. UNIPROT:Q6PEM5 Database accession no. Q6PEM5 *

Also Published As

Publication number Publication date
US20120135936A1 (en) 2012-05-31
AU2010250104A1 (en) 2011-10-27
JP2012527459A (ja) 2012-11-08
US9051390B2 (en) 2015-06-09
EP2432487A4 (en) 2013-01-02
EP2432487B1 (en) 2016-03-02
EP2432487A1 (en) 2012-03-28
WO2010134970A8 (en) 2011-11-10
WO2010134970A1 (en) 2010-11-25
JP5862560B2 (ja) 2016-02-16
CA2755948A1 (en) 2010-11-25
AU2010250104A8 (en) 2012-06-07

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TH Corrigenda

Free format text: IN VOL 25, NO 42, PAGE(S) 5267 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME AMERICAN NATIONAL RED CROSS, APPLICATION NO. 2010250104, UNDER INID (54) CORRECT THE TITLE TO READ INHIBITION OF PRION PROTEIN PROPAGATION BY RECEPTOR ASSOCIATED PROTEIN (RAP). ITS DERIVATIVES, MIMETICS AND SYNTHETIC PEPTIDES

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired