AU2009338693B2 - Multi-material abrading head for atherectomy devices having laterally displaced center of mass - Google Patents
Multi-material abrading head for atherectomy devices having laterally displaced center of mass Download PDFInfo
- Publication number
- AU2009338693B2 AU2009338693B2 AU2009338693A AU2009338693A AU2009338693B2 AU 2009338693 B2 AU2009338693 B2 AU 2009338693B2 AU 2009338693 A AU2009338693 A AU 2009338693A AU 2009338693 A AU2009338693 A AU 2009338693A AU 2009338693 B2 AU2009338693 B2 AU 2009338693B2
- Authority
- AU
- Australia
- Prior art keywords
- drive shaft
- eccentric
- speed
- abrading
- atherectomy device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000000463 material Substances 0.000 title claims abstract description 64
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 7
- 239000010935 stainless steel Substances 0.000 claims abstract description 7
- 229910052715 tantalum Inorganic materials 0.000 claims abstract description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims abstract description 4
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229910052721 tungsten Inorganic materials 0.000 claims abstract description 4
- 239000010937 tungsten Substances 0.000 claims abstract description 4
- 210000001367 artery Anatomy 0.000 claims description 29
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 24
- 230000036262 stenosis Effects 0.000 claims description 22
- 208000037804 stenosis Diseases 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 20
- 239000010410 layer Substances 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 abstract description 25
- 239000002184 metal Substances 0.000 abstract description 25
- 238000000926 separation method Methods 0.000 abstract description 3
- 210000001519 tissue Anatomy 0.000 description 19
- 238000005520 cutting process Methods 0.000 description 13
- 230000002966 stenotic effect Effects 0.000 description 12
- 239000007787 solid Substances 0.000 description 9
- 239000003082 abrasive agent Substances 0.000 description 7
- 239000002245 particle Substances 0.000 description 6
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 238000002399 angioplasty Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 229910003460 diamond Inorganic materials 0.000 description 4
- 239000010432 diamond Substances 0.000 description 4
- 238000010276 construction Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 238000002679 ablation Methods 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 229910052580 B4C Inorganic materials 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- NRTOMJZYCJJWKI-UHFFFAOYSA-N Titanium nitride Chemical compound [Ti]#N NRTOMJZYCJJWKI-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- INAHAJYZKVIDIZ-UHFFFAOYSA-N boron carbide Chemical compound B12B3B4C32B41 INAHAJYZKVIDIZ-UHFFFAOYSA-N 0.000 description 1
- 238000005219 brazing Methods 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000007788 roughening Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- UONOETXJSWQNOL-UHFFFAOYSA-N tungsten carbide Chemical compound [W+]#[C-] UONOETXJSWQNOL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B2017/320004—Surgical cutting instruments abrasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B2017/320733—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a flexible cutting or scraping element, e.g. with a whip-like distal filament member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
- A61B2017/320766—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven eccentric
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/363,914 | 2009-02-02 | ||
| US12/363,914 US8795303B2 (en) | 2009-02-02 | 2009-02-02 | Multi-material abrading head for atherectomy devices having laterally displaced center of mass |
| PCT/US2009/068420 WO2010087910A1 (en) | 2009-02-02 | 2009-12-17 | Multi-material abrading head for atherectomy devices having laterally displaced center of mass |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2009338693A1 AU2009338693A1 (en) | 2011-07-28 |
| AU2009338693B2 true AU2009338693B2 (en) | 2015-01-29 |
Family
ID=42395929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009338693A Ceased AU2009338693B2 (en) | 2009-02-02 | 2009-12-17 | Multi-material abrading head for atherectomy devices having laterally displaced center of mass |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8795303B2 (enExample) |
| EP (1) | EP2391281B1 (enExample) |
| JP (1) | JP5588462B2 (enExample) |
| CN (1) | CN102300510B (enExample) |
| AU (1) | AU2009338693B2 (enExample) |
| CA (1) | CA2749741A1 (enExample) |
| WO (1) | WO2010087910A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9907567B2 (en) * | 2010-05-04 | 2018-03-06 | Samuel Shiber | Mechanical — pharmaceutical system for opening obstructed bodily vessels |
| US9289230B2 (en) * | 2012-09-17 | 2016-03-22 | Cardiovascular Systems, Inc. | Rotational atherectomy device with a system of eccentric abrading heads |
| EP2967635B1 (en) | 2013-03-12 | 2017-06-28 | Boston Scientific Scimed, Inc. | Vibration and inertia enhanced atherectomy |
| US20140316447A1 (en) * | 2013-03-14 | 2014-10-23 | Cardiovascular Systems, Inc. | Devices, systems and methods for a piloting tip bushing for rotational atherectomy |
| US20150080795A1 (en) | 2013-07-26 | 2015-03-19 | Cardiovascular Systems, Inc. | Devices, systems and methods for performing atherectomy and subsequent balloon angioplasty without exchanging devices |
| US20150089785A1 (en) * | 2013-09-30 | 2015-04-02 | Cardiovascular Systems, Inc. | Method of attaching an element to a drive shaft |
| USD766433S1 (en) * | 2013-11-04 | 2016-09-13 | Cardiovascular Systems, Inc. | Eccentric crown |
| US10271869B2 (en) | 2014-03-01 | 2019-04-30 | Rex Medical, L.P. | Atherectomy device |
| CN106456208B (zh) | 2014-03-12 | 2020-04-03 | 波士顿科学有限公司 | 注入润滑斑块切除导管 |
| US10405878B2 (en) | 2014-07-25 | 2019-09-10 | Boston Scientific Scimed, Inc. | Rotatable medical device |
| WO2016089847A1 (en) | 2014-12-04 | 2016-06-09 | Boston Scientific Scimed, Inc. | Rotatable medical device |
| US10463389B2 (en) | 2014-12-27 | 2019-11-05 | Rex Medical, L.P. | Atherectomy device |
| US10433868B2 (en) | 2014-12-27 | 2019-10-08 | Rex Medical, L.P. | Artherectomy device |
| US10299820B2 (en) | 2015-02-20 | 2019-05-28 | Cardiovascular Systems, Inc. | Methods and systems for disrupting calcified walls of biological conduits and calcified lesions therein |
| US11253292B2 (en) | 2015-09-13 | 2022-02-22 | Rex Medical, L.P. | Atherectomy device |
| US10307175B2 (en) | 2016-03-26 | 2019-06-04 | Rex Medical, L.P | Atherectomy device |
| US10945757B2 (en) * | 2016-10-18 | 2021-03-16 | The Regents Of The University Of Michigan | Two-phase technique to restore artery patency and a catheter temperature control system in atherectomy |
| US11051842B2 (en) | 2017-05-03 | 2021-07-06 | Medtronic Vascular, Inc. | Tissue-removing catheter with guidewire isolation liner |
| US11690645B2 (en) | 2017-05-03 | 2023-07-04 | Medtronic Vascular, Inc. | Tissue-removing catheter |
| CN118697424A (zh) | 2018-11-16 | 2024-09-27 | 美敦力瓦斯科尔勒公司 | 组织去除导管 |
| US11819236B2 (en) | 2019-05-17 | 2023-11-21 | Medtronic Vascular, Inc. | Tissue-removing catheter |
| CN114727833A (zh) * | 2019-11-20 | 2022-07-08 | 波士顿科学国际有限公司 | 复合动脉粥样硬化切除旋磨头 |
| US11523841B2 (en) | 2020-09-03 | 2022-12-13 | Cardiovascular Systems, Inc. | Systems, methods and devices for removal of thrombus and/or soft plaque with asymmetric mass distribution within working region of impeller |
| WO2022219528A1 (en) * | 2021-04-12 | 2022-10-20 | Medtronic Vascular, Inc. | Tissue removing catheter with tissue-removing element having oblique distal end face |
| CN114916997B (zh) * | 2022-05-31 | 2025-11-04 | 上海微创旋律医疗科技有限公司 | 旋磨装置及旋磨设备 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6132444A (en) * | 1997-08-14 | 2000-10-17 | Shturman Cardiology Systems, Inc. | Eccentric drive shaft for atherectomy device and method for manufacture |
| US6494890B1 (en) * | 1997-08-14 | 2002-12-17 | Shturman Cardiology Systems, Inc. | Eccentric rotational atherectomy device |
| US20030125756A1 (en) * | 2001-10-19 | 2003-07-03 | Leonid Shturman | Rotational angioplasty device with abrasive crown |
| WO2006126076A2 (en) * | 2005-05-26 | 2006-11-30 | Leonid Shturman | Rotational atherectomy device with distal protection capability and method of use |
| US20080306498A1 (en) * | 2007-06-11 | 2008-12-11 | Cardiovascular Systems, Inc. | Eccentric abrading head for high-speed rotational atherectomy devices |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1881821A (en) | 1931-06-01 | 1932-10-11 | Charles M Clarke | Tube cleaner |
| US2221195A (en) | 1939-02-20 | 1940-11-12 | Apamenondas S Ketsios | Flue cleaner |
| US2348132A (en) | 1942-02-03 | 1944-05-02 | John W Hyland | Hydraulic brake cylinder cleaner and polisher |
| GB957612A (en) * | 1960-09-27 | 1964-05-06 | Cammell Laird & Company Shipbu | Improvements in or relating to machine bearings |
| US3507695A (en) * | 1967-04-18 | 1970-04-21 | Beehler Vernon D | Utilization of sound wave energy |
| CH603261A5 (enExample) | 1976-03-24 | 1978-08-15 | Rio Beer | |
| US4181998A (en) | 1978-08-01 | 1980-01-08 | Carrier Corporation | Tube cleaning apparatus |
| DE3103475A1 (de) | 1981-02-03 | 1982-08-26 | Robert Bosch Gmbh, 7000 Stuttgart | Elektrische maschine, insbesondere kleinmotor |
| US4732154A (en) | 1984-05-14 | 1988-03-22 | Surgical Systems & Instruments, Inc. | Rotary catheter system |
| CA1293663C (en) | 1986-01-06 | 1991-12-31 | David Christopher Auth | Transluminal microdissection device |
| US4795438A (en) | 1987-05-13 | 1989-01-03 | Intravascular Surgical Instruments, Inc. | Method and apparatus for forming a restriction in a vessel, duct or lumen |
| US4811735A (en) | 1987-07-30 | 1989-03-14 | Kensey Nash Corporation | Stone destroying catheter and method of use |
| US5087265A (en) | 1989-02-17 | 1992-02-11 | American Biomed, Inc. | Distal atherectomy catheter |
| US5226909A (en) | 1989-09-12 | 1993-07-13 | Devices For Vascular Intervention, Inc. | Atherectomy device having helical blade and blade guide |
| US5100425A (en) | 1989-09-14 | 1992-03-31 | Medintec R&D Limited Partnership | Expandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses |
| US5030201A (en) | 1989-11-24 | 1991-07-09 | Aubrey Palestrant | Expandable atherectomy catheter device |
| US5222959A (en) | 1990-07-17 | 1993-06-29 | Anis Aziz Y | Removal of tissue |
| US5242461A (en) | 1991-07-22 | 1993-09-07 | Dow Corning Wright | Variable diameter rotating recanalization catheter and surgical method |
| FR2685190B1 (fr) | 1991-12-23 | 1998-08-07 | Jean Marie Lefebvre | Dispositif rotatif d'atherectomie ou de thrombectomie a developpement transversal centrifuge. |
| US5360432A (en) | 1992-10-16 | 1994-11-01 | Shturman Cardiology Systems, Inc. | Abrasive drive shaft device for directional rotational atherectomy |
| US5643297A (en) | 1992-11-09 | 1997-07-01 | Endovascular Instruments, Inc. | Intra-artery obstruction clearing apparatus and methods |
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| IT1280397B1 (it) * | 1995-03-14 | 1998-01-20 | Iat Istituto Analitico Tuscane | Dispositivo decalcificatore anticalcare a risonanza variabile, collegato a trasformatore del tipo a rifasamento sequenzionale |
| US5681336A (en) * | 1995-09-07 | 1997-10-28 | Boston Scientific Corporation | Therapeutic device for treating vien graft lesions |
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| US6015420A (en) * | 1997-03-06 | 2000-01-18 | Scimed Life Systems, Inc. | Atherectomy device for reducing damage to vessels and/or in-vivo stents |
| US6146395A (en) | 1998-03-05 | 2000-11-14 | Scimed Life Systems, Inc. | Ablation burr |
| US6096054A (en) * | 1998-03-05 | 2000-08-01 | Scimed Life Systems, Inc. | Expandable atherectomy burr and method of ablating an occlusion from a patient's blood vessel |
| US6296639B1 (en) | 1999-02-12 | 2001-10-02 | Novacept | Apparatuses and methods for interstitial tissue removal |
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| US7344546B2 (en) | 2000-04-05 | 2008-03-18 | Pathway Medical Technologies | Intralumenal material removal using a cutting device for differential cutting |
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| US6451037B1 (en) | 2000-11-22 | 2002-09-17 | Scimed Life Systems, Inc. | Expandable atherectomy burr with metal reinforcement |
| US6436111B1 (en) | 2000-12-19 | 2002-08-20 | Scimed Life Systems, Inc. | Expandable atherectomy burr |
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| WO2006126065A1 (en) | 2005-05-23 | 2006-11-30 | Van Der Vijver, Brian | A method and apparatus for drying sphagnum peat moss |
| GB2426456B (en) * | 2005-05-26 | 2010-10-27 | Leonid Shturman | Rotational device with eccentric abrasive element and method of use |
| US8348965B2 (en) * | 2007-10-23 | 2013-01-08 | Cardiovascular Systems, Inc. | Rotational atherectomy device with counterweighting |
-
2009
- 2009-02-02 US US12/363,914 patent/US8795303B2/en active Active
- 2009-12-17 CN CN200980155982.9A patent/CN102300510B/zh active Active
- 2009-12-17 JP JP2011547934A patent/JP5588462B2/ja active Active
- 2009-12-17 AU AU2009338693A patent/AU2009338693B2/en not_active Ceased
- 2009-12-17 WO PCT/US2009/068420 patent/WO2010087910A1/en not_active Ceased
- 2009-12-17 EP EP09839467.9A patent/EP2391281B1/en active Active
- 2009-12-17 CA CA2749741A patent/CA2749741A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6132444A (en) * | 1997-08-14 | 2000-10-17 | Shturman Cardiology Systems, Inc. | Eccentric drive shaft for atherectomy device and method for manufacture |
| US6494890B1 (en) * | 1997-08-14 | 2002-12-17 | Shturman Cardiology Systems, Inc. | Eccentric rotational atherectomy device |
| US20030125756A1 (en) * | 2001-10-19 | 2003-07-03 | Leonid Shturman | Rotational angioplasty device with abrasive crown |
| WO2006126076A2 (en) * | 2005-05-26 | 2006-11-30 | Leonid Shturman | Rotational atherectomy device with distal protection capability and method of use |
| US20080306498A1 (en) * | 2007-06-11 | 2008-12-11 | Cardiovascular Systems, Inc. | Eccentric abrading head for high-speed rotational atherectomy devices |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102300510B (zh) | 2014-07-30 |
| US8795303B2 (en) | 2014-08-05 |
| EP2391281B1 (en) | 2019-02-20 |
| JP2012516707A (ja) | 2012-07-26 |
| JP5588462B2 (ja) | 2014-09-10 |
| EP2391281A4 (en) | 2013-05-29 |
| CA2749741A1 (en) | 2010-08-05 |
| US20100198239A1 (en) | 2010-08-05 |
| EP2391281A1 (en) | 2011-12-07 |
| AU2009338693A1 (en) | 2011-07-28 |
| CN102300510A (zh) | 2011-12-28 |
| WO2010087910A1 (en) | 2010-08-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |