AU2008297586B2 - Monoclonal antibodies specific to hemagglutinin from influenza virus H5-subtype and uses thereof - Google Patents

Monoclonal antibodies specific to hemagglutinin from influenza virus H5-subtype and uses thereof Download PDF

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Publication number
AU2008297586B2
AU2008297586B2 AU2008297586A AU2008297586A AU2008297586B2 AU 2008297586 B2 AU2008297586 B2 AU 2008297586B2 AU 2008297586 A AU2008297586 A AU 2008297586A AU 2008297586 A AU2008297586 A AU 2008297586A AU 2008297586 B2 AU2008297586 B2 AU 2008297586B2
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AU
Australia
Prior art keywords
antibody
subtype
virus
avian influenza
influenza virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2008297586A
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English (en)
Other versions
AU2008297586A1 (en
Inventor
Fang He
Hwei-Sing Kwang
Hong Liang Qian
Siti Fadilah Supari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NATIONAL INSTITUTE OF HEALTH RESEARCH AND DEVELOPMENT (NIHRD)- MINISTRY OF HEALTH OF REPUBLIC OF INDONESIA
Temasek Life Sciences Laboratory Ltd
Original Assignee
National Institute Of Health Res And Development Nihrd Ministry Of Health Of Republic Of Indones
Temasek Life Sciences Laboratory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Institute Of Health Res And Development Nihrd Ministry Of Health Of Republic Of Indones, Temasek Life Sciences Laboratory Ltd filed Critical National Institute Of Health Res And Development Nihrd Ministry Of Health Of Republic Of Indones
Publication of AU2008297586A1 publication Critical patent/AU2008297586A1/en
Application granted granted Critical
Publication of AU2008297586B2 publication Critical patent/AU2008297586B2/en
Ceased legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2008297586A 2007-09-13 2008-08-26 Monoclonal antibodies specific to hemagglutinin from influenza virus H5-subtype and uses thereof Ceased AU2008297586B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97208707P 2007-09-13 2007-09-13
US60/972,087 2007-09-13
PCT/SG2008/000313 WO2009035412A1 (en) 2007-09-13 2008-08-26 Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof

Publications (2)

Publication Number Publication Date
AU2008297586A1 AU2008297586A1 (en) 2009-03-19
AU2008297586B2 true AU2008297586B2 (en) 2013-06-20

Family

ID=40452263

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008297586A Ceased AU2008297586B2 (en) 2007-09-13 2008-08-26 Monoclonal antibodies specific to hemagglutinin from influenza virus H5-subtype and uses thereof

Country Status (5)

Country Link
US (2) US8444986B2 (https=)
EP (1) EP2207804B1 (https=)
JP (1) JP5490695B2 (https=)
AU (1) AU2008297586B2 (https=)
WO (1) WO2009035412A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2687147C (en) * 2007-05-11 2016-08-23 Temasek Life Sciences Laboratory Limited H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance
AU2008297594B2 (en) 2007-09-13 2013-06-20 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof
EP2563389B1 (en) * 2010-04-30 2015-07-08 Temasek Life Sciences Laboratory Limited Universal vaccine against h5n1 lineages
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
EP3374390A1 (en) 2015-11-13 2018-09-19 Visterra, Inc. Compositions and methods for treating and preventing influenza
AU2017222564A1 (en) 2016-02-24 2018-09-06 Visterra, Inc. Formulations of antibody molecules to influenza virus
US10766929B2 (en) 2017-03-15 2020-09-08 University Of Washington De novo designed hemagglutinin binding proteins
CN107831306B (zh) * 2017-10-10 2020-04-24 武汉科前生物股份有限公司 一种h7亚型禽流感病毒双抗体夹心elisa试剂盒及其检测方法
US11780907B2 (en) 2018-01-26 2023-10-10 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
CN113355344B (zh) * 2021-08-10 2021-11-02 北京溯本源和生物科技有限公司 一种流感病毒ns1蛋白的表达质粒、重组蛋白和特异性单克隆抗体及应用
CN117683126B (zh) * 2023-11-08 2025-11-21 华南农业大学 纳米抗体蛋白、用途、表达载体、菌株和药物以及试剂盒
CN120424203B (zh) * 2025-03-24 2026-04-17 华南农业大学 抗h5亚型禽流感病毒纳米抗体及其构建方法和用途
CN120329427B (zh) * 2025-06-19 2025-08-29 中国人民解放军军事科学院军事医学研究院 一种针对禽流感病毒h5n1血凝素单克隆抗体及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007089753A2 (en) 2006-01-26 2007-08-09 Hx Diagnostics, Inc. Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and uses thereof
EP2450377A1 (en) * 2006-09-07 2012-05-09 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof
CA2687147C (en) * 2007-05-11 2016-08-23 Temasek Life Sciences Laboratory Limited H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance
US7879326B2 (en) * 2007-06-15 2011-02-01 The Board Of Trustees Of The Leland Stanford Junior University Human neutralizing monoclonal antibodies to H5N1 influenza A virus

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHEN, J. ET AL. Journal of Veterinary Diagnostic Investigation (March 2007) Volume 19, pages 155-160 *
Database GenBank, Accession number CY014481, 30 August 2006 *
HARLOW, E. AND LANE, D. Antibodies: A Laboratory Manual. USA: Cold Springs Harbour Laboratory 1988. *
KRICKA, L. J. 'Principles of Immunochemical Techniques' In BURTIS, C. A. ET AL. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics 4th Edition. St Louis, Missouri: Elsevier Saunders, 2006. *
NETTLES, V. F. ET AL. Avian Diseases (1985) Volume 29, Number 3, pages 733-741 *
SMIRNOV, Y. A. ET AL. Acta Virologica (1999) Volume 43, pages 237-244 *
SMIRNOV, Y. A. ET AL.Archives of Virology (2000) Volume 145, page 1733-1741 *
SUAREZ, D. L. AND SCHULTZ-CHERRY, S. (2000) Developmental and Comparative Immunology (2000) Volume 24, pages 269-283 *
VEITS, J. ET AL. Proceedings of the National Academy of Sciences (USA) (2006) Volume 103, Number 21, pages 8197-8202 *

Also Published As

Publication number Publication date
AU2008297586A1 (en) 2009-03-19
JP5490695B2 (ja) 2014-05-14
JP2010539161A (ja) 2010-12-16
WO2009035412A1 (en) 2009-03-19
US8444986B2 (en) 2013-05-21
US20130251715A1 (en) 2013-09-26
WO2009035412A8 (en) 2009-05-22
US20100297126A1 (en) 2010-11-25
EP2207804A1 (en) 2010-07-21
EP2207804B1 (en) 2015-07-22
US9115188B2 (en) 2015-08-25
EP2207804A4 (en) 2012-04-18

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AU2008297586B2 (en) Monoclonal antibodies specific to hemagglutinin from influenza virus H5-subtype and uses thereof
AU2008297594B2 (en) Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof
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MK14 Patent ceased section 143(a) (annual fees not paid) or expired