AU2003301851A1 - Azacyclic compounds as orexin receptor antagonist - Google Patents

Azacyclic compounds as orexin receptor antagonist

Info

Publication number
AU2003301851A1
AU2003301851A1 AU2003301851A AU2003301851A AU2003301851A1 AU 2003301851 A1 AU2003301851 A1 AU 2003301851A1 AU 2003301851 A AU2003301851 A AU 2003301851A AU 2003301851 A AU2003301851 A AU 2003301851A AU 2003301851 A1 AU2003301851 A1 AU 2003301851A1
Authority
AU
Australia
Prior art keywords
receptor antagonist
orexin receptor
azacyclic compounds
azacyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003301851A
Inventor
Clive Leslie Branch
Jean-Pierre Pilleux
Roderick Alan Porter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2003301851A1 publication Critical patent/AU2003301851A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
AU2003301851A 2002-11-06 2003-11-04 Azacyclic compounds as orexin receptor antagonist Abandoned AU2003301851A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0225884.6 2002-11-06
GBGB0225884.6A GB0225884D0 (en) 2002-11-06 2002-11-06 Novel compounds
PCT/EP2003/012403 WO2004041816A1 (en) 2002-11-06 2003-11-04 Azacyclic compounds as orexin receptor antagonist

Publications (1)

Publication Number Publication Date
AU2003301851A1 true AU2003301851A1 (en) 2004-06-07

Family

ID=9947317

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003301851A Abandoned AU2003301851A1 (en) 2002-11-06 2003-11-04 Azacyclic compounds as orexin receptor antagonist

Country Status (3)

Country Link
AU (1) AU2003301851A1 (en)
GB (1) GB0225884D0 (en)
WO (1) WO2004041816A1 (en)

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HUP0400405A3 (en) * 2004-02-10 2009-03-30 Sanofi Synthelabo Pyrimidine derivatives, process for producing them, their use, pharmaceutical compositions containing them and their intermediates
KR100848747B1 (en) 2004-03-01 2008-07-25 액테리온 파마슈티칼 리미티드 Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
US8618102B2 (en) 2006-07-14 2013-12-31 Merck Sharp & Dohme Corp. Bridged diazepan orexin receptor antagonists
WO2008038251A2 (en) * 2006-09-29 2008-04-03 Actelion Pharmaceuticals Ltd 3-aza-bicyclo[3.1.0]hexane derivatives
WO2008065626A2 (en) 2006-12-01 2008-06-05 Actelion Pharmaceuticals Ltd 3-heteroaryl (amino or amido)-1- (biphenyl or phenylthiazolyl) carbonylpiperidine derivativesas orexin receptor inhibitors
PE20081229A1 (en) 2006-12-01 2008-08-28 Merck & Co Inc DIAZEPAM OREXIN RECEPTOR ANTAGONISTS REPLACED
CL2007003827A1 (en) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd COMPOUNDS DERIVED FROM N- (2-AZA-BICYCLE (3.1.0) HEX-3-ILMETIL) AMIDA; AND ITS USE TO PREVENT OR TREAT DEPRESSION, NEUROSIS, SCHIZOPHRENIA, ANXIETY, ADDICTIONS, EPILEPSY, PAIN, HEART DISEASES, AMONG OTHERS.
CL2008000836A1 (en) 2007-03-26 2008-11-07 Actelion Pharmaceuticals Ltd Thiazolidine derivative compounds, orexin receptor antagonists; pharmaceutical composition that includes them; and its use in the treatment of emotional neurosis, severe depression, psychotic disorders, Alzheimer's, parkinson's, pain, among others.
BRPI0811842A2 (en) 2007-05-23 2014-11-18 Merck & Co Inc COMPOUND, PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, AND METHODS TO INCREASE SLEEP QUALITY IN A MAMMALIAN PATIENT, TO TREAT INSOMNIA IN A MAMMALIAN PATIENT, AND TO TREAT OR CONTROL OBESITY IN A MAMMALIAN PATIENT
US8030495B2 (en) 2007-05-23 2011-10-04 Coleman Paul J Cyclopropyl pyrrolidine orexin receptor antagonists
BRPI0814593A2 (en) 2007-07-27 2015-01-20 Actelion Pharmaceuticals Ltd COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING AND USE OF THE COMPOUND.
CA2699328A1 (en) 2007-09-24 2009-04-02 Actelion Pharmaceuticals Ltd Pyrrolidines and piperidines as orexin receptor antagonists
RU2010138640A (en) 2008-02-21 2012-03-27 Актелион Фармасьютиклз Лтд (Ch) 2-AZA-Bicyclo [2.2.1] HEPTANE DERIVATIVES
CN102300858A (en) * 2008-12-02 2011-12-28 葛兰素集团有限公司 N-{[(ir,4s,6r-3-(2-pyridinylcarbonyl)-3-azabicyclo [4.1.0] Hept-4-yl] Methyl}-2-heteroarylamine Derivatives And Uses Thereof
KR20110091582A (en) * 2008-12-02 2011-08-11 글락소 그룹 리미티드 N-{[(1r,4s,6r-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and uses thereof
US20120258957A1 (en) 2009-11-23 2012-10-11 Matilda Jane Bingham Heterocyclic derivatives
JP5588018B2 (en) * 2009-12-29 2014-09-10 スベン ライフ サイエンシズ リミティド α4β2 neuronal nicotinic acetylcholine receptor ligand
AR088352A1 (en) 2011-10-19 2014-05-28 Merck Sharp & Dohme ANTAGONISTS OF THE RECEIVER OF 2-PIRIDILOXI-4-NITRILE OREXINE
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
NZ628491A (en) 2012-02-07 2016-06-24 Eolas Therapeutics Inc Substituted prolines / piperidines as orexin receptor antagonists
ITMI20120424A1 (en) * 2012-03-19 2013-09-20 Rottapharm Spa CHEMICAL COMPOUNDS
TWI510481B (en) 2012-06-04 2015-12-01 Actelion Pharmaceuticals Ltd Benzimidazole-proline derivatives
AU2013328301A1 (en) 2012-10-10 2015-05-28 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero-)aryl]-[2-(meta bi (hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
JP2016510810A (en) 2013-03-12 2016-04-11 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Azetidine amide derivatives as orexin receptor antagonists
UA119151C2 (en) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist
PT3077389T (en) 2013-12-03 2017-12-15 Idorsia Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
HUE040555T2 (en) 2013-12-04 2019-03-28 Idorsia Pharmaceuticals Ltd Use of benzimidazole-proline derivatives
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
AU2017217931B2 (en) 2016-02-12 2020-10-22 Astrazeneca Ab Halo-substituted piperidines as orexin receptor modulators
EP3454857A1 (en) 2016-05-10 2019-03-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
TW202400149A (en) 2022-05-13 2024-01-01 瑞士商愛杜西亞製藥有限公司 Thiazoloaryl-methyl substituted cyclic hydrazine-n-carboxamide derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2361390A1 (en) * 1973-12-10 1975-06-19 Merck Patent Gmbh ISOCHINOLINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
JP2786479B2 (en) * 1989-05-31 1998-08-13 三田工業株式会社 Image reading processor
HU227811B1 (en) * 2000-03-14 2012-03-28 Actelion Pharmaceuticals Ltd 1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes
EP1288202A4 (en) * 2000-05-11 2003-07-02 Banyu Pharma Co Ltd N-acyltetrahydroisoquinoline derivatives
ES2238458T3 (en) * 2000-06-16 2005-09-01 Smithkline Beecham Plc PIPERIDINS FOR USE AS ANTAGONISTS OF OREXIN RECEPTORS.

Also Published As

Publication number Publication date
WO2004041816A1 (en) 2004-05-21
GB0225884D0 (en) 2002-12-11

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase