AU2003287574A1 - Calmodulin independent activation of nitric oxide synthase by nadph analogs - Google Patents

Calmodulin independent activation of nitric oxide synthase by nadph analogs

Info

Publication number
AU2003287574A1
AU2003287574A1 AU2003287574A AU2003287574A AU2003287574A1 AU 2003287574 A1 AU2003287574 A1 AU 2003287574A1 AU 2003287574 A AU2003287574 A AU 2003287574A AU 2003287574 A AU2003287574 A AU 2003287574A AU 2003287574 A1 AU2003287574 A1 AU 2003287574A1
Authority
AU
Australia
Prior art keywords
nitric oxide
oxide synthase
independent activation
calmodulin
nadph analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003287574A
Other versions
AU2003287574A8 (en
Inventor
John C. Salerno
Susan M. E. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rensselaer Polytechnic Institute
Original Assignee
Rensselaer Polytechnic Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rensselaer Polytechnic Institute filed Critical Rensselaer Polytechnic Institute
Publication of AU2003287574A1 publication Critical patent/AU2003287574A1/en
Publication of AU2003287574A8 publication Critical patent/AU2003287574A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
    • C12N9/0075—Nitric-oxide synthase (1.14.13.39)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/13—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen (1.14.13)
    • C12Y114/13039—Nitric-oxide synthase (NADPH dependent) (1.14.13.39)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AU2003287574A 2002-11-07 2003-11-07 Calmodulin independent activation of nitric oxide synthase by nadph analogs Abandoned AU2003287574A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42465302P 2002-11-07 2002-11-07
US60/424,653 2002-11-07
PCT/US2003/035570 WO2004044194A2 (en) 2002-11-07 2003-11-07 Calmodulin independent activation of nitric oxide synthase by nadph analogs

Publications (2)

Publication Number Publication Date
AU2003287574A1 true AU2003287574A1 (en) 2004-06-03
AU2003287574A8 AU2003287574A8 (en) 2004-06-03

Family

ID=32312847

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003287574A Abandoned AU2003287574A1 (en) 2002-11-07 2003-11-07 Calmodulin independent activation of nitric oxide synthase by nadph analogs

Country Status (4)

Country Link
EP (1) EP1563063A2 (en)
AU (1) AU2003287574A1 (en)
CA (1) CA2505118A1 (en)
WO (1) WO2004044194A2 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677290A (en) * 1990-05-10 1997-10-14 Fukunaga; Atsuo F. Therapeutic use of adenosine compounds as surgical anesthetics
US5801159A (en) * 1996-02-23 1998-09-01 Galileo Laboratories, Inc. Method and composition for inhibiting cellular irreversible changes due to stress

Also Published As

Publication number Publication date
EP1563063A2 (en) 2005-08-17
CA2505118A1 (en) 2004-05-27
WO2004044194A3 (en) 2004-07-08
AU2003287574A8 (en) 2004-06-03
WO2004044194A2 (en) 2004-05-27

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase