AU2003286411A1 - Glycogen synthase kinase-3 inhibitors - Google Patents
Glycogen synthase kinase-3 inhibitors Download PDFInfo
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- AU2003286411A1 AU2003286411A1 AU2003286411A AU2003286411A AU2003286411A1 AU 2003286411 A1 AU2003286411 A1 AU 2003286411A1 AU 2003286411 A AU2003286411 A AU 2003286411A AU 2003286411 A AU2003286411 A AU 2003286411A AU 2003286411 A1 AU2003286411 A1 AU 2003286411A1
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- residue
- acid
- gsk
- amino acid
- polypeptide
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
- C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
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- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
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- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
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- Biotechnology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Obesity (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US43264402P | 2002-12-12 | 2002-12-12 | |
| US60/432,644 | 2002-12-12 | ||
| US48271903P | 2003-06-27 | 2003-06-27 | |
| US60/482,719 | 2003-06-27 | ||
| PCT/IL2003/001057 WO2004052404A2 (en) | 2002-12-12 | 2003-12-11 | Glycogen synthase kinase-3 inhibitors |
Publications (1)
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| AU2003286411A1 true AU2003286411A1 (en) | 2004-06-30 |
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| EP (1) | EP1569956B1 (https=) |
| JP (1) | JP2006514104A (https=) |
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| AU (1) | AU2003286411A1 (https=) |
| CA (1) | CA2509374A1 (https=) |
| WO (1) | WO2004052404A2 (https=) |
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| US7378432B2 (en) * | 2001-09-14 | 2008-05-27 | Tel Aviv University Future Technology Development L.P. | Glycogen synthase kinase-3 inhibitors |
| WO2004052404A2 (en) * | 2002-12-12 | 2004-06-24 | Tel Aviv University Future Technology Development L.P. | Glycogen synthase kinase-3 inhibitors |
| AU2005234687A1 (en) * | 2003-06-27 | 2005-12-08 | Tel Aviv Universtiy Future Technology Development L.P. | Glycogen Synthase Kinase-3 Inhibitors |
| US20100144827A1 (en) * | 2006-12-20 | 2010-06-10 | Medwell Laboratories Ltd. C/O Ngt Technological Incubator | Novel conjugates of polyunsaturated fatty acids with amines and therapeutic uses thereof |
| WO2009154697A2 (en) | 2008-05-28 | 2009-12-23 | Massachusetts Institute Of Technology | Disc-1 pathway activators in the control of neurogenesis |
| AU2008258150B1 (en) * | 2008-12-16 | 2009-03-19 | Jorge Miguel Pereira | An Improved Knee Pad |
| WO2010098888A1 (en) * | 2009-02-27 | 2010-09-02 | Massachusetts Institute Of Technology | Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders |
| EP2668199B1 (en) | 2011-01-27 | 2017-09-06 | Ramot at Tel Aviv University, Ltd. | Glycogen synthase kinase-3 inhibitors |
| EP2668200B1 (en) | 2011-01-27 | 2017-03-15 | Ramot at Tel-Aviv University Ltd. | Glycogen synthase kinase-3 inhibitors |
| US9718859B2 (en) | 2013-06-24 | 2017-08-01 | Ramot At Tel-Aviv University Ltd. | Glycogen synthase kinase-3 inhibitors |
| CA2945263A1 (en) | 2014-04-09 | 2015-10-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
| CN107148425B (zh) | 2014-10-29 | 2021-08-03 | 拜斯科阿迪有限公司 | 对mt1-mmp特异性的双环肽配体 |
| US20190389907A1 (en) * | 2016-12-23 | 2019-12-26 | Bicycletx Limited | Peptide ligands for binding to mt1-mmp |
| WO2018115203A1 (en) * | 2016-12-23 | 2018-06-28 | Bicyclerd Limited | Peptide derivatives having novel linkage structures |
| EP3645549A1 (en) | 2017-06-26 | 2020-05-06 | BicycleRD Limited | Bicyclic peptide ligands with detectable moieties and uses thereof |
| JP7670481B2 (ja) | 2017-08-04 | 2025-04-30 | バイスクルテクス・リミテッド | Ｃｄ１３７に対して特異的な二環式ペプチドリガンド |
| CN111902429A (zh) | 2018-02-23 | 2020-11-06 | 拜斯科技术开发有限公司 | 多聚体双环肽配体 |
| GB201810320D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to CD38 |
| GB201810329D0 (en) * | 2018-06-22 | 2018-08-08 | Bicycletx Ltd | Peptide ligands for binding to integrin avB3 |
| IL279489B2 (en) | 2018-06-22 | 2025-10-01 | Bicycletx Ltd | Bicyclic peptide ligands specific for nectin-4, a drug conjugate containing the peptide ligands and a pharmaceutical composition containing the drug conjugate |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| US12492224B2 (en) | 2018-12-21 | 2025-12-09 | Bicycletx Limited | Bicyclic peptide ligands specific for PD-L1 |
| WO2020128527A1 (en) | 2018-12-21 | 2020-06-25 | Bicyclerd Limited | Bicyclic peptide ligands specific for pd-l1 |
| GB201900529D0 (en) | 2019-01-15 | 2019-03-06 | Bicycletx Ltd | Bicyclic peptide ligands specific for CD38 |
| GB201900530D0 (en) * | 2019-01-15 | 2019-03-06 | Bicyclerd Ltd | Bicyclic peptide ligands specific for CD38 |
| TWI860386B (zh) | 2019-07-30 | 2024-11-01 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| AU2021322934A1 (en) | 2020-08-03 | 2023-03-30 | Bicycletx Limited | Peptide-based linkers |
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| US3193159A (en) * | 1964-02-24 | 1965-07-06 | Vernon E Swindler | Dispenser for comminuted material and the like |
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| US5861266A (en) | 1994-02-28 | 1999-01-19 | New York University | Treatment of diabetes mellitus and insulin receptor signal transduction |
| US5462101A (en) * | 1994-07-05 | 1995-10-31 | Mouchmouchian; Silva | Baby feeding system |
| US5807718A (en) | 1994-12-02 | 1998-09-15 | The Scripps Research Institute | Enzymatic DNA molecules |
| DE19524133A1 (de) | 1995-07-03 | 1997-01-09 | Bayer Ag | Die Verwendung von neuen und bekannten kationischen 4,5-Dihydro-1H-1,2,3-triazoliumverbindungen als Farbstoffe, neue kationische 4,5-Dihydro-1H-1,2,3-triazoliumverbindungen und deren Herstellung |
| US5948765A (en) | 1996-03-15 | 1999-09-07 | Washington University | Inhibition of intracellular signal transduction by 14-3-3-binding peptides |
| US6057117A (en) * | 1996-04-04 | 2000-05-02 | Chiron Corporation | Identification and use of selective inhibitors of glycogen synthase kinase 3 |
| WO1997041854A1 (en) | 1996-05-07 | 1997-11-13 | The Trustees Of The University Of Pennsylvania | Inhibitors of glycogen synthase kinase-3 and methods for identifying and using the same |
| US6077954A (en) | 1996-08-01 | 2000-06-20 | Isis Pharmaceuticals, Inc. | Substituted heterocyclic compounds |
| WO1998016528A1 (en) | 1996-10-11 | 1998-04-23 | Chiron Corporation | Purine inhibitors of glycogen synthase kinase 3 (gsk3) |
| US6441140B1 (en) | 1998-09-04 | 2002-08-27 | Cell Signaling Technology, Inc. | Production of motif-specific and context-independent antibodies using peptide libraries as antigens |
| AU2316500A (en) | 1999-01-27 | 2000-08-18 | Enbaya Ltd. | Progressive compression of triangular meshes |
| US6495376B1 (en) | 1999-02-18 | 2002-12-17 | Beth Israel Deaconess Medical Center | Methods and compositions for regulating protein-protein interactions |
| GB9906245D0 (en) | 1999-03-19 | 1999-05-12 | Medical Res Council | Enzyme |
| IL133243A0 (en) | 1999-03-30 | 2001-03-19 | Univ Ramot | A method and system for super resolution |
| IL130325A0 (en) | 1999-06-07 | 2000-06-01 | Yeda Res & Dev | Pharmaceutical compositions comprising allicin |
| WO2001049709A1 (en) * | 2000-01-03 | 2001-07-12 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Glycogen synthase kinase-3 inhibitors |
| CA2417507A1 (en) | 2000-08-21 | 2002-02-28 | Pacific Corporation | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
| AU2001287914A1 (en) * | 2000-09-22 | 2002-04-02 | University Of Dundee The | Protein kinase regulation |
| US7378432B2 (en) * | 2001-09-14 | 2008-05-27 | Tel Aviv University Future Technology Development L.P. | Glycogen synthase kinase-3 inhibitors |
| GB2396109B (en) | 2002-12-12 | 2006-04-19 | Johnson & Johnson Medical Ltd | Absorbent multilayer hydrogel wound dressings |
| WO2004052404A2 (en) | 2002-12-12 | 2004-06-24 | Tel Aviv University Future Technology Development L.P. | Glycogen synthase kinase-3 inhibitors |
| AU2005234687A1 (en) | 2003-06-27 | 2005-12-08 | Tel Aviv Universtiy Future Technology Development L.P. | Glycogen Synthase Kinase-3 Inhibitors |
| EP1638557A4 (en) | 2003-06-27 | 2007-11-07 | Univ Tel Aviv Future Tech Dev | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 |
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| EP1569956A2 (en) | 2005-09-07 |
| US20060135408A1 (en) | 2006-06-22 |
| US7446092B2 (en) | 2008-11-04 |
| KR20050091716A (ko) | 2005-09-15 |
| US20090062180A1 (en) | 2009-03-05 |
| WO2004052404A2 (en) | 2004-06-24 |
| US7833974B2 (en) | 2010-11-16 |
| CA2509374A1 (en) | 2004-06-24 |
| EP1569956B1 (en) | 2014-02-26 |
| WO2004052404A3 (en) | 2004-07-29 |
| JP2006514104A (ja) | 2006-04-27 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |