AU2003277215A8 - Novel neurokinin antagonists and methods of use thereof - Google Patents

Novel neurokinin antagonists and methods of use thereof

Info

Publication number
AU2003277215A8
AU2003277215A8 AU2003277215A AU2003277215A AU2003277215A8 AU 2003277215 A8 AU2003277215 A8 AU 2003277215A8 AU 2003277215 A AU2003277215 A AU 2003277215A AU 2003277215 A AU2003277215 A AU 2003277215A AU 2003277215 A8 AU2003277215 A8 AU 2003277215A8
Authority
AU
Australia
Prior art keywords
methods
neurokinin antagonists
novel neurokinin
novel
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003277215A
Other versions
AU2003277215A1 (en
Inventor
Dale S Dhanoa
Sacham Sharon
Venkitasamy Kesavan
Ori Kalid
Anurag Sharadendu
Oren Becker
Pradyumna Mohanty
Dongli Chen
Yael Marantz
Silvia Noiman
Raphael Nudelman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Predix Pharmaceuticals Holdings Inc
Original Assignee
Predix Pharmaceuticals Holdings Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Predix Pharmaceuticals Holdings Inc filed Critical Predix Pharmaceuticals Holdings Inc
Publication of AU2003277215A8 publication Critical patent/AU2003277215A8/en
Publication of AU2003277215A1 publication Critical patent/AU2003277215A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003277215A 2002-10-01 2003-09-30 Novel neurokinin antagonists and methods of use thereof Abandoned AU2003277215A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US41504502P 2002-10-01 2002-10-01
US60/415,045 2002-10-01
US42518602P 2002-11-08 2002-11-08
US42518702P 2002-11-08 2002-11-08
US42513002P 2002-11-08 2002-11-08
US60/425,187 2002-11-08
US60/425,130 2002-11-08
US60/425,186 2002-11-08
PCT/US2003/031153 WO2004030629A2 (en) 2002-10-01 2003-09-30 Novel neurokinin antagonists and methods of use thereof

Publications (2)

Publication Number Publication Date
AU2003277215A8 true AU2003277215A8 (en) 2004-04-23
AU2003277215A1 AU2003277215A1 (en) 2004-04-23

Family

ID=32074647

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003277215A Abandoned AU2003277215A1 (en) 2002-10-01 2003-09-30 Novel neurokinin antagonists and methods of use thereof

Country Status (2)

Country Link
AU (1) AU2003277215A1 (en)
WO (1) WO2004030629A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612078B2 (en) 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7488736B2 (en) 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7407966B2 (en) 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7576211B2 (en) 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
DE102004055998A1 (en) 2004-11-19 2006-05-24 Rheinische Friedrich-Wilhelms-Universität Bonn Low molecular weight inhibitors of guanine nucleotide exchange factors of the cytohesin family
MX2010007430A (en) 2008-01-11 2010-12-21 Albany Molecular Res Inc (1-azinone) -substituted pyridoindoles as mch antagonists.
EP2445877B1 (en) 2008-12-03 2014-07-23 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
WO2011003021A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
US8637501B2 (en) 2009-07-01 2014-01-28 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003007A1 (en) 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
WO2012088124A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
WO2018130123A1 (en) * 2017-01-11 2018-07-19 南京圣和药业股份有限公司 Pentacyclic compound as selective estrogen receptor down-regulator and use thereof
JP7336469B2 (en) 2017-09-08 2023-08-31 シムベリックス，インコーポレーティッド Compounds, compositions, and methods that selectively inhibit beta-glucuronidase and alleviate side effects associated with drug-induced diarrhea

Also Published As

Publication number Publication date
WO2004030629A3 (en) 2004-11-04
WO2004030629A2 (en) 2004-04-15
AU2003277215A1 (en) 2004-04-23

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase