AU2003234638A1 - Luminogenic protease substrates - Google Patents

Luminogenic protease substrates

Info

Publication number
AU2003234638A1
AU2003234638A1 AU2003234638A AU2003234638A AU2003234638A1 AU 2003234638 A1 AU2003234638 A1 AU 2003234638A1 AU 2003234638 A AU2003234638 A AU 2003234638A AU 2003234638 A AU2003234638 A AU 2003234638A AU 2003234638 A1 AU2003234638 A1 AU 2003234638A1
Authority
AU
Australia
Prior art keywords
protease substrates
luminogenic
luminogenic protease
substrates
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003234638A
Other versions
AU2003234638A8 (en
Inventor
Zhenjun Diwu
Jinfang Liao
Zhiqiang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Devices LLC
Original Assignee
Molecular Devices LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Devices LLC filed Critical Molecular Devices LLC
Publication of AU2003234638A8 publication Critical patent/AU2003234638A8/en
Publication of AU2003234638A1 publication Critical patent/AU2003234638A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AU2003234638A 2002-05-24 2003-05-23 Luminogenic protease substrates Abandoned AU2003234638A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38336302P 2002-05-24 2002-05-24
US60/383,363 2002-05-24
PCT/US2003/016530 WO2003099780A2 (en) 2002-05-24 2003-05-23 Luminogenic protease substrates

Publications (2)

Publication Number Publication Date
AU2003234638A8 AU2003234638A8 (en) 2003-12-12
AU2003234638A1 true AU2003234638A1 (en) 2003-12-12

Family

ID=29584553

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003234638A Abandoned AU2003234638A1 (en) 2002-05-24 2003-05-23 Luminogenic protease substrates

Country Status (3)

Country Link
EP (1) EP1517997A4 (en)
AU (1) AU2003234638A1 (en)
WO (1) WO2003099780A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047245A2 (en) 2003-11-14 2005-05-26 Wisconsin Alumni Research Foundation Fluorescence assays with improved blocking groups
WO2009045104A1 (en) * 2007-10-05 2009-04-09 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Method for diagnosing presymptomatic organ transplant rejection
US8460862B2 (en) * 2009-03-11 2013-06-11 Marker Gene Technologies Enzyme substrates for visualizing acidic organelles
US20130023675A1 (en) * 2010-01-13 2013-01-24 The University Of Tokyo Diagnostic for cancer
FR2978164B1 (en) * 2011-07-22 2013-08-30 Stago Diagnostica USE OF A SUBSTRATE IN A METHOD FOR MEASURING THE ACTIVITY OF PROTEOLYTIC ENZYMES
FR2978163B1 (en) * 2011-07-22 2013-08-30 Stago Diagnostica USE OF A SUBSTRATE IN A METHOD FOR MEASURING THE ACTIVITY OF PROTEOLYTIC ENZYMES AVAILABLE
ES2655212T3 (en) 2012-07-19 2018-02-19 Kingston University Higher Education Corporation Fluorescent probe based on rhodamine to determine coagulase activity and detection of bacterial strains producing coagulase
WO2016006678A1 (en) * 2014-07-11 2016-01-14 国立大学法人 東京大学 Fluorescent probe for detecting dipeptidyl peptidase iv
JP6881294B2 (en) * 2015-02-27 2021-06-02 国立大学法人 東京大学 Calpain activity detection fluorescent probe
CN109438319B (en) * 2018-09-17 2022-05-10 湖北大学 Compound for detecting leucine aminopeptidase and preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4640893A (en) * 1983-10-28 1987-02-03 University Of Illinois Novel rhodamine derivatives as fluorogenic substrates for proteinases
US4557862A (en) * 1983-10-28 1985-12-10 University Patents, Inc. Rhodamine derivatives as fluorogenic substrates for proteinases
AU5116099A (en) * 1998-07-21 2000-02-14 Sui Xiong Cai Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
DE60001531T2 (en) * 1999-04-23 2003-10-02 Molecular Probes Inc XANTHENE DYES AND THEIR USE AS LUMINESCENT EXTINGUISHING COMPOUNDS

Also Published As

Publication number Publication date
WO2003099780A2 (en) 2003-12-04
EP1517997A4 (en) 2006-11-15
AU2003234638A8 (en) 2003-12-12
EP1517997A2 (en) 2005-03-30
WO2003099780A3 (en) 2004-04-01

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase