AU2003233238A1 - Fap-activated anti-tumor prodrugs - Google Patents

Fap-activated anti-tumor prodrugs

Info

Publication number
AU2003233238A1
AU2003233238A1 AU2003233238A AU2003233238A AU2003233238A1 AU 2003233238 A1 AU2003233238 A1 AU 2003233238A1 AU 2003233238 A AU2003233238 A AU 2003233238A AU 2003233238 A AU2003233238 A AU 2003233238A AU 2003233238 A1 AU2003233238 A1 AU 2003233238A1
Authority
AU
Australia
Prior art keywords
fap
activated anti
prodrugs
tumor
tumor prodrugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003233238A
Other versions
AU2003233238A8 (en
Inventor
John Edward Park
Erik Patzelt
Stefan Peters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Publication of AU2003233238A1 publication Critical patent/AU2003233238A1/en
Publication of AU2003233238A8 publication Critical patent/AU2003233238A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2003233238A 2002-05-10 2003-05-06 Fap-activated anti-tumor prodrugs Abandoned AU2003233238A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02010552.4 2002-05-10
EP02010552 2002-05-10
PCT/EP2003/004713 WO2003094972A2 (en) 2002-05-10 2003-05-06 Fap-activated anti-tumor prodrugs

Publications (2)

Publication Number Publication Date
AU2003233238A1 true AU2003233238A1 (en) 2003-11-11
AU2003233238A8 AU2003233238A8 (en) 2003-11-11

Family

ID=29414680

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003233238A Abandoned AU2003233238A1 (en) 2002-05-10 2003-05-06 Fap-activated anti-tumor prodrugs

Country Status (3)

Country Link
EP (1) EP1506221A2 (en)
AU (1) AU2003233238A1 (en)
WO (1) WO2003094972A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087131A2 (en) * 2006-01-05 2007-08-02 The Johns Hopkins University Peptide prodrugs
US9737556B2 (en) 2014-06-13 2017-08-22 Trustees Of Tufts College FAP-activated therapeutic agents, and uses related thereto
EP4267188A1 (en) 2020-12-22 2023-11-01 Cobiores NV Compounds comprising a tetrapeptidic moiety
WO2022167664A1 (en) 2021-02-07 2022-08-11 Cobiores Nv Compounds comprising a tetrapeptidic moiety

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0855910A4 (en) * 1995-10-18 2000-07-05 Merck & Co Inc Conjugates useful in the treatment of benign prostatic hyperplasia
IL143666A0 (en) * 1998-12-11 2002-04-21 Coulter Pharm Inc Prodrug compounds and process for preparation thereof
US6613879B1 (en) * 1999-05-14 2003-09-02 Boehringer Ingelheim Pharma Kg FAP-activated anti-tumour compounds
DE60239679D1 (en) * 2001-06-11 2011-05-19 Medarex Inc METHOD FOR MACHINING CD10-ACTIVATED PRODRUG COMPOUNDS

Also Published As

Publication number Publication date
WO2003094972A2 (en) 2003-11-20
WO2003094972A3 (en) 2004-03-18
AU2003233238A8 (en) 2003-11-11
EP1506221A2 (en) 2005-02-16

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
TH Corrigenda

Free format text: IN VOL 18, NO 2, PAGE(S) 488 UNDER THE HEADING APPLICATIONS OPI - NAME INDEX UNDER THE NAME BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG, APPLICATION NO. 2003233238, UNDER INID(43) CORRECT THE PUBLICATION DATE TO READ 24.11.2003