AU2003221528A1 - 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position - Google Patents

19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position

Info

Publication number
AU2003221528A1
AU2003221528A1 AU2003221528A AU2003221528A AU2003221528A1 AU 2003221528 A1 AU2003221528 A1 AU 2003221528A1 AU 2003221528 A AU2003221528 A AU 2003221528A AU 2003221528 A AU2003221528 A AU 2003221528A AU 2003221528 A1 AU2003221528 A1 AU 2003221528A1
Authority
AU
Australia
Prior art keywords
pregna
trien
ols
long chain
lactone ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003221528A
Inventor
Karl-Heinrich Fritzemeier
Alexander Hillisch
Jens Hoffmann
Gerd Muller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of AU2003221528A1 publication Critical patent/AU2003221528A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention relates to novel 19-nor-17 alpha -pregna-1,3,5(10)-trien-17 beta -ols with a 21,16 alpha lactone ring and a long chain substituent in the 11 beta position of general formula (II) where R<11> is a 6 to 17 C straight chain alkyl group and R<3> and R<13> have the meanings more closely given in the description. The compounds have a tissue-selective pure anti-oestrogen effect and are thus suitable for the production of medicaments.
AU2003221528A 2002-03-27 2003-03-27 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position Abandoned AU2003221528A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10214180.0 2002-03-27
DE10214180A DE10214180A1 (en) 2002-03-27 2002-03-27 11beta-lankgettig-substituted 19-nor-17alpha-pregna-1,3,5 (10) -triene-17beta-ols with a 21,16alpha lactone ring
PCT/EP2003/003226 WO2003080641A1 (en) 2002-03-27 2003-03-27 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position

Publications (1)

Publication Number Publication Date
AU2003221528A1 true AU2003221528A1 (en) 2003-10-08

Family

ID=28050972

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003221528A Abandoned AU2003221528A1 (en) 2002-03-27 2003-03-27 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position

Country Status (8)

Country Link
EP (1) EP1490391B1 (en)
JP (1) JP2005526805A (en)
AT (1) ATE313552T1 (en)
AU (1) AU2003221528A1 (en)
DE (2) DE10214180A1 (en)
DK (1) DK1490391T3 (en)
ES (1) ES2254924T3 (en)
WO (1) WO2003080641A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089874A (en) * 1961-05-31 1963-05-14 Abbott Lab Steroid lactones
DE1255659B (en) * 1961-05-31 1967-12-07 Abbott Lab Process for the manufacture of steroid lactones
US3920634A (en) * 1974-08-30 1975-11-18 Lilly Co Eli 2,3-Dihydroestra-1,3,5(10)-trieno (16{60 ,17{60 -{62 ) furan-17{62 ols
DE10048634A1 (en) * 2000-09-27 2002-04-18 Jenapharm Gmbh 19-Nor-17alpha-pregna-1,3,5 (10) -trien-17beta-ole with a 21, 16alpha lactone ring

Also Published As

Publication number Publication date
WO2003080641A1 (en) 2003-10-02
ATE313552T1 (en) 2006-01-15
DE50302000D1 (en) 2006-01-26
DK1490391T3 (en) 2006-04-18
JP2005526805A (en) 2005-09-08
EP1490391A1 (en) 2004-12-29
EP1490391B1 (en) 2005-12-21
DE10214180A1 (en) 2003-10-16
ES2254924T3 (en) 2006-06-16

Similar Documents

Publication Publication Date Title
DE69831868D1 (en) Antithrombosemittel
DE69830504D1 (en) ANTITROMOMBOTIC MEANS
PL369740A1 (en) Novel dihydropteridinones, method for producing the same and the use thereof as medicaments
YU69902A (en) New piperazine derivatives
AU2055500A (en) Aromatic amides
AR026410A1 (en) &#39;&#39; 2-ARIL-3- (HETEROARIL) -IMIDAZO [1,2-A] SUBSTITUTED PYRIMIDINS, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS
AU2002351124A1 (en) Pyrazoles-pyrimidine fungicides
ME00440B (en) Novel $g(b crystalline form of perindopril tert-butylamine salt, preparation method, and pharmaceutical compositions containing same
YU94103A (en) Novel sulfonic acid derivatives
EP1831239B8 (en) A process for the preparation of 17-hydroxy-6 beta, 7 beta, 15 beta, 16 beta -bismethylene-17 alpha-pregn-4-ene-3-one-21-carboxylic acid gamma-lactone and key-intermediates for this process
NO20005671D0 (en) Metabolites of ecteinascidin 743
RS50229B (en) Vitamin d3 analogs
MA27610A1 (en) ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF BETA-AMYLOID PEPTIDE
ATE280767T1 (en) ANTIDIABETIC THIAZOLIDINDIONES AND THEIR PRODUCTION
DE60114640D1 (en) Antithrombosemittel
IL159718A0 (en) Synthesis of intermediates for preparation of stating derivatives
GB0212410D0 (en) Organic compounds
MY125378A (en) Pentacyclic taxan compound
DE60107832D1 (en) Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
AU4424401A (en) Novel lipoic acid heterocyclic or benzene derivatives, preparation and use thereof as medicines
AU2003221528A1 (en) 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position
CA2440186A1 (en) Medicinal composition containing 1,3-thiazine derivative
WO2004065360A3 (en) Piperazine derivatives and their use as synthesis intermediates
MXPA04003086A (en) A process for the stereoselective synthesis of 2-hydroxymethyl-chromans.
HK1083839A1 (en) Indoline compound and medicinal use thereof

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase