AU2003221528A1 - 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position - Google Patents
19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta positionInfo
- Publication number
- AU2003221528A1 AU2003221528A1 AU2003221528A AU2003221528A AU2003221528A1 AU 2003221528 A1 AU2003221528 A1 AU 2003221528A1 AU 2003221528 A AU2003221528 A AU 2003221528A AU 2003221528 A AU2003221528 A AU 2003221528A AU 2003221528 A1 AU2003221528 A1 AU 2003221528A1
- Authority
- AU
- Australia
- Prior art keywords
- pregna
- trien
- ols
- long chain
- lactone ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
The invention relates to novel 19-nor-17 alpha -pregna-1,3,5(10)-trien-17 beta -ols with a 21,16 alpha lactone ring and a long chain substituent in the 11 beta position of general formula (II) where R<11> is a 6 to 17 C straight chain alkyl group and R<3> and R<13> have the meanings more closely given in the description. The compounds have a tissue-selective pure anti-oestrogen effect and are thus suitable for the production of medicaments.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10214180A DE10214180A1 (en) | 2002-03-27 | 2002-03-27 | 11beta-lankgettig-substituted 19-nor-17alpha-pregna-1,3,5 (10) -triene-17beta-ols with a 21,16alpha lactone ring |
DE10214180.0 | 2002-03-27 | ||
PCT/EP2003/003226 WO2003080641A1 (en) | 2002-03-27 | 2003-03-27 | 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2003221528A1 true AU2003221528A1 (en) | 2003-10-08 |
Family
ID=28050972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2003221528A Abandoned AU2003221528A1 (en) | 2002-03-27 | 2003-03-27 | 19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ols with a 21,16alpha-lactone ring substituted with a long chain at the 11beta position |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1490391B1 (en) |
JP (1) | JP2005526805A (en) |
AT (1) | ATE313552T1 (en) |
AU (1) | AU2003221528A1 (en) |
DE (2) | DE10214180A1 (en) |
DK (1) | DK1490391T3 (en) |
ES (1) | ES2254924T3 (en) |
WO (1) | WO2003080641A1 (en) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3089874A (en) * | 1961-05-31 | 1963-05-14 | Abbott Lab | Steroid lactones |
DE1255659B (en) * | 1961-05-31 | 1967-12-07 | Abbott Lab | Process for the manufacture of steroid lactones |
US3920634A (en) * | 1974-08-30 | 1975-11-18 | Lilly Co Eli | 2,3-Dihydroestra-1,3,5(10)-trieno (16{60 ,17{60 -{62 ) furan-17{62 ols |
DE10048634A1 (en) * | 2000-09-27 | 2002-04-18 | Jenapharm Gmbh | 19-Nor-17alpha-pregna-1,3,5 (10) -trien-17beta-ole with a 21, 16alpha lactone ring |
-
2002
- 2002-03-27 DE DE10214180A patent/DE10214180A1/en not_active Withdrawn
-
2003
- 2003-03-27 DE DE50302000T patent/DE50302000D1/en not_active Expired - Fee Related
- 2003-03-27 AU AU2003221528A patent/AU2003221528A1/en not_active Abandoned
- 2003-03-27 WO PCT/EP2003/003226 patent/WO2003080641A1/en active IP Right Grant
- 2003-03-27 EP EP03717244A patent/EP1490391B1/en not_active Expired - Lifetime
- 2003-03-27 AT AT03717244T patent/ATE313552T1/en not_active IP Right Cessation
- 2003-03-27 ES ES03717244T patent/ES2254924T3/en not_active Expired - Lifetime
- 2003-03-27 JP JP2003578394A patent/JP2005526805A/en active Pending
- 2003-03-27 DK DK03717244T patent/DK1490391T3/en active
Also Published As
Publication number | Publication date |
---|---|
WO2003080641A1 (en) | 2003-10-02 |
JP2005526805A (en) | 2005-09-08 |
EP1490391A1 (en) | 2004-12-29 |
DE10214180A1 (en) | 2003-10-16 |
DK1490391T3 (en) | 2006-04-18 |
ATE313552T1 (en) | 2006-01-15 |
DE50302000D1 (en) | 2006-01-26 |
ES2254924T3 (en) | 2006-06-16 |
EP1490391B1 (en) | 2005-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |