AU2003209776A1 - Tissue-type plasminogen activator (t-pa) inhibitors with a therapeutic capacity - Google Patents

Tissue-type plasminogen activator (t-pa) inhibitors with a therapeutic capacity

Info

Publication number
AU2003209776A1
AU2003209776A1 AU2003209776A AU2003209776A AU2003209776A1 AU 2003209776 A1 AU2003209776 A1 AU 2003209776A1 AU 2003209776 A AU2003209776 A AU 2003209776A AU 2003209776 A AU2003209776 A AU 2003209776A AU 2003209776 A1 AU2003209776 A1 AU 2003209776A1
Authority
AU
Australia
Prior art keywords
inhibitors
tissue
plasminogen activator
type plasminogen
therapeutic capacity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003209776A
Inventor
Victor Diaz Cortes
Rosanna Paciucci Barzanti
Timothy Thomson Okatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HOSPITAL VALL D'HEBRON
REVENTOS PUIGJANER
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
HOSPITAL VALL D HEBRON
REVENTOS PUIGJANER
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HOSPITAL VALL D HEBRON, REVENTOS PUIGJANER, Consejo Superior de Investigaciones Cientificas CSIC filed Critical HOSPITAL VALL D HEBRON
Publication of AU2003209776A1 publication Critical patent/AU2003209776A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003209776A 2002-02-15 2003-02-14 Tissue-type plasminogen activator (t-pa) inhibitors with a therapeutic capacity Abandoned AU2003209776A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200200369A ES2214089B1 (en) 2002-02-15 2002-02-15 PROCEDURE FOR IDENTIFICATION OF INHIBITORS OF THE TISSULAR PLASMINOGEN ACTIVATOR (T-PA) WITH THERAPEUTIC CAPACITY.
ESP0200369 2002-02-15
PCT/ES2003/000082 WO2003068950A1 (en) 2002-02-15 2003-02-14 Tissue-type plasminogen activator (t-pa) inhibitors with a therapeutic capacity

Publications (1)

Publication Number Publication Date
AU2003209776A1 true AU2003209776A1 (en) 2003-09-04

Family

ID=27675925

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003209776A Abandoned AU2003209776A1 (en) 2002-02-15 2003-02-14 Tissue-type plasminogen activator (t-pa) inhibitors with a therapeutic capacity

Country Status (3)

Country Link
AU (1) AU2003209776A1 (en)
ES (2) ES2268921B1 (en)
WO (1) WO2003068950A1 (en)

Also Published As

Publication number Publication date
ES2214089A1 (en) 2004-09-01
ES2268921B1 (en) 2008-03-16
ES2268921A1 (en) 2007-03-16
WO2003068950A1 (en) 2003-08-21
ES2214089B1 (en) 2005-11-01

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase